JPH11310524A - Oral liquid preparation - Google Patents
Oral liquid preparationInfo
- Publication number
- JPH11310524A JPH11310524A JP10117652A JP11765298A JPH11310524A JP H11310524 A JPH11310524 A JP H11310524A JP 10117652 A JP10117652 A JP 10117652A JP 11765298 A JP11765298 A JP 11765298A JP H11310524 A JPH11310524 A JP H11310524A
- Authority
- JP
- Japan
- Prior art keywords
- aluminum hydroxide
- flavor
- liquid preparation
- cider
- oral liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000796 flavoring agent Substances 0.000 claims abstract description 26
- 235000019634 flavors Nutrition 0.000 claims abstract description 26
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims abstract description 22
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 claims abstract description 6
- 241000207199 Citrus Species 0.000 claims abstract description 5
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 5
- RCSBILYQLVXLJG-UHFFFAOYSA-N 2-Propenyl hexanoate Chemical compound CCCCCC(=O)OCC=C RCSBILYQLVXLJG-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 4
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims abstract description 3
- 235000011941 Tilia x europaea Nutrition 0.000 claims abstract description 3
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 235000005487 catechin Nutrition 0.000 claims abstract description 3
- 229950001002 cianidanol Drugs 0.000 claims abstract description 3
- 239000004571 lime Substances 0.000 claims abstract description 3
- 244000248349 Citrus limon Species 0.000 claims abstract 2
- 235000019987 cider Nutrition 0.000 claims description 16
- 239000003205 fragrance Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims description 4
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 4
- AOGQPLXWSUTHQB-UHFFFAOYSA-N hexyl acetate Chemical compound CCCCCCOC(C)=O AOGQPLXWSUTHQB-UHFFFAOYSA-N 0.000 claims description 4
- MLFHJEHSLIIPHL-UHFFFAOYSA-N isoamyl acetate Chemical compound CC(C)CCOC(C)=O MLFHJEHSLIIPHL-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- VAMXMNNIEUEQDV-UHFFFAOYSA-N methyl anthranilate Chemical compound COC(=O)C1=CC=CC=C1N VAMXMNNIEUEQDV-UHFFFAOYSA-N 0.000 claims description 4
- CFNJLPHOBMVMNS-UHFFFAOYSA-N pentyl butyrate Chemical compound CCCCCOC(=O)CCC CFNJLPHOBMVMNS-UHFFFAOYSA-N 0.000 claims description 4
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims description 2
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 2
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 claims description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 claims description 2
- 235000005513 chalcones Nutrition 0.000 claims description 2
- 229930016911 cinnamic acid Natural products 0.000 claims description 2
- 235000013985 cinnamic acid Nutrition 0.000 claims description 2
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims description 2
- 235000012734 epicatechin Nutrition 0.000 claims description 2
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 229940117955 isoamyl acetate Drugs 0.000 claims description 2
- 229940102398 methyl anthranilate Drugs 0.000 claims description 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 2
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 235000019640 taste Nutrition 0.000 claims description 2
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 claims description 2
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims description 2
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 2
- 235000012141 vanillin Nutrition 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 235000019606 astringent taste Nutrition 0.000 abstract description 13
- 229940100688 oral solution Drugs 0.000 abstract description 9
- 235000019993 champagne Nutrition 0.000 abstract description 7
- 230000000873 masking effect Effects 0.000 abstract description 7
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 abstract description 3
- 238000013329 compounding Methods 0.000 abstract description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 5
- 240000004307 Citrus medica Species 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 15
- 229940024545 aluminum hydroxide Drugs 0.000 description 14
- 238000009472 formulation Methods 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 5
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 3
- 239000000347 magnesium hydroxide Substances 0.000 description 3
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 229940085605 saccharin sodium Drugs 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 208000018556 stomach disease Diseases 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940024548 aluminum oxide Drugs 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 208000024798 heartburn Diseases 0.000 description 1
- 229960001545 hydrotalcite Drugs 0.000 description 1
- 229910001701 hydrotalcite Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000008368 mint flavor Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、服用性が改善され
た経口液剤に関する。TECHNICAL FIELD The present invention relates to an oral liquid preparation having improved ingestibility.
【0002】[0002]
【従来の技術】水酸化アルミニウムは制酸成分として知
られ、胃の障害、すなわち吐き気、胃痙攣、胸やけ、飽
食感などを治療または予防するために用いられている。
また、製剤の剤形も服用性の点から液剤として調製する
ことが多い。しかし水酸化アルミニウムは、独特の収斂
味を中心とした不快風味を有しており、液剤としたとき
の風味の点で満足できなかった。また、胃の障害を有す
る患者は薬剤の風味に敏感になる場合が多く、胃の障害
が比較的軽度であっても、従来の水酸化アルミニウムを
含有した経口液剤を服用する場合、苦痛を伴っていた。2. Description of the Related Art Aluminum hydroxide is known as an antacid component and is used for treating or preventing disorders of the stomach, such as nausea, gastric spasm, heartburn and satiety.
In addition, the dosage form of the preparation is often prepared as a liquid from the viewpoint of ingestibility. However, aluminum hydroxide has an unpleasant flavor with a unique astringent taste, and was not satisfactory in terms of flavor when used as a liquid preparation. In addition, patients with stomach disorders are often sensitive to the flavor of the drug, and even if the stomach disorders are relatively mild, taking conventional oral solutions containing aluminum hydroxide is painful. I was
【0003】[0003]
【発明が解決しようとする課題】本発明の目的は、水酸
化アルミニウムを配合した経口液剤の風味を改善するこ
とにある。SUMMARY OF THE INVENTION An object of the present invention is to improve the taste of an oral solution containing aluminum hydroxide.
【0004】[0004]
【課題を解決するための手段】本発明者らは種々検討し
た結果、水酸化アルミニウムを配合した液剤にサイダー
系の香料を配合すると、水酸化アルミニウム由来の収斂
味を特異的に低減させ、しかも収斂味のマスキング効果
が経時的に劣化しにくいこと見出し本発明を完成した。Means for Solving the Problems As a result of various studies, the present inventors have found that when a cider-based fragrance is added to a solution containing aluminum hydroxide, the astringent taste derived from aluminum hydroxide can be specifically reduced. The present inventors have found that the masking effect of the astringent taste does not easily deteriorate with time, and completed the present invention.
【0005】すなわち本発明は、水酸化アルミニウムお
よびサイダー系香料を含有することを特徴とする経口液
剤である。That is, the present invention is an oral solution characterized by containing aluminum hydroxide and a cider-based flavor.
【0006】本発明の効果はサイダー系香料が持つシト
ラス様のトップノートが、水酸化アルミニウムの収斂味
の発現と重なることによりマスキング効果が生じている
ものと推測される。The effect of the present invention is presumed to be that the citrus-like top note of the cider-based fragrance overlaps with the expression of the astringent taste of aluminum hydroxide to produce a masking effect.
【0007】[0007]
【発明の実施の形態】本発明で水酸化アルミニウムと
は、乾燥水酸化アルミニウムゲル、合成ケイ酸アルミニ
ウム、酸化アルミニウム、水酸化アルミニウムゲル、水
酸化アルミニウムゲル・炭酸水素ナトリウム共沈生成物
などが由来のものをあげることができるが、酸化アルミ
ニウム由来のものが特に好ましい。液剤中の水酸化アル
ミニウムの配合量は、水酸化アルミニウムに換算して製
剤全体の30〜70重量%が好ましく、50〜60重量
%がさらに好ましい。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, aluminum hydroxide is derived from dried aluminum hydroxide gel, synthetic aluminum silicate, aluminum oxide, aluminum hydroxide gel, aluminum hydroxide gel / sodium hydrogen carbonate coprecipitation product, and the like. And those derived from aluminum oxide are particularly preferred. The compounding amount of aluminum hydroxide in the liquid preparation is preferably 30 to 70% by weight, more preferably 50 to 60% by weight, of the whole preparation in terms of aluminum hydroxide.
【0008】本発明で用いるサイダー系香料は、シトロ
ンサイダー系、シャンペンサイダー系、レモンサイダー
系などが使用できるが、収斂味低減の点からシャンペン
サイダー系香料が特に好ましい。As the cider-based fragrance used in the present invention, citron-sided, champagne-sided, lemon-cider-based fragrances and the like can be used.
【0009】本発明で用いるサイダー系香料は0.5〜
5重量%の実質香気成分と95〜99.5重量%の溶媒
成分から構成されている。The cider-based flavor used in the present invention is 0.5 to
It is composed of 5% by weight of a real fragrance component and 95 to 99.5% by weight of a solvent component.
【0010】本発明で用いるサイダー系香料の実質香気
成分は、レモン、ライム、オレンジなどのシトラス系の
成分を柱とし、他の果実の香りを構成しているエステル
類を配合したものである。具体的には、(A)シトラス
系の香気成分を中心とし、さらに(B)フルフラール、
(C)Allyl Caproate、Amyl Butyrate、Benzyl Acetat
e、Ethyl Acetate、Ethyl Acetoacetate、Ethyl Butyra
te、Ethyl Caproate、Hexyl Acetate、Isoamyl Acetate
およびMethyl Anthranilateからなる群から選ばれる1
種または2種以上、ならびに(D)カテキン、エピカテ
キン、プロトカテキン酸、カルコン、ケイヒ酸またはそ
の誘導体、3,4,5-Trihydroxybenzoicacid、バニリン、
バニリン酸、3,5-Dimetoxy-4-hydroxybenzoicacidおよ
び3,5-Dimetoxy-4-hydroxybenzaldehydeからなる群から
選ばれる1種または2種以上、を含有するものをいう。The real flavor component of the cider-based flavor used in the present invention is a mixture of citrus-based components such as lemon, lime, and orange as pillars, and esters that constitute the flavor of other fruits. Specifically, (A) the citrus fragrance component is mainly used, and (B) furfural,
(C) Allyl Caproate, Amyl Butyrate, Benzyl Acetat
e, Ethyl Acetate, Ethyl Acetoacetate, Ethyl Butyra
te, Ethyl Caproate, Hexyl Acetate, Isoamyl Acetate
1 selected from the group consisting of and Methyl Anthranilate
Species or two or more, and (D) catechin, epicatechin, protocatechinic acid, chalcone, cinnamic acid or a derivative thereof, 3,4,5-Trihydroxybenzoicacid, vanillin,
It means one containing one or more selected from the group consisting of vanillic acid, 3,5-Dimetoxy-4-hydroxybenzoicacid and 3,5-Dimetoxy-4-hydroxybenzaldehyde.
【0011】香料の配合量は経口液剤中の水酸化アルミ
ニウム1重量部に対して0.0014〜0.0035重
量部が好ましい。The amount of the fragrance is preferably 0.0014 to 0.0035 parts by weight per 1 part by weight of aluminum hydroxide in the oral solution.
【0012】本発明の液剤とは溶液剤の他、懸濁剤、乳
剤などをも包含した概念である。The solution of the present invention is a concept that includes not only a solution but also a suspension, an emulsion and the like.
【0013】本発明の経口液剤は、収斂味のマスキング
効果の点からpH=6〜9の範囲が好ましく、pH=7
〜8の範囲がさらに好ましい。pHの調整は、一般的な
pH調整剤を使用することができ、クエン酸、リンゴ
酸、リン酸、塩酸などが好ましい。The oral solution of the present invention preferably has a pH of 6 to 9, and has a pH of 7 from the viewpoint of an astringent masking effect.
The range of from to 8 is more preferable. For pH adjustment, a general pH adjuster can be used, and citric acid, malic acid, phosphoric acid, hydrochloric acid and the like are preferable.
【0014】本発明の経口液剤は、ケイ酸マグネシウ
ム、合成ヒドロタルサイト、酸化マグネシウム、水酸化
マグネシウム、炭酸水素ナトリウム、炭酸マグネシウ
ム、沈降炭酸カルシウム、無水リン酸水素カルシウム、
リン酸水素カルシウム、ボレイなどをさらに配合するこ
ともできる。The oral solution of the present invention comprises magnesium silicate, synthetic hydrotalcite, magnesium oxide, magnesium hydroxide, sodium hydrogen carbonate, magnesium carbonate, precipitated calcium carbonate, anhydrous calcium hydrogen phosphate,
Calcium hydrogen phosphate, volley and the like can be further added.
【0015】本発明の経口液剤は液剤製造の通常の方法
で製造することができる。The oral solution of the present invention can be produced by a usual method for producing a solution.
【0016】[0016]
【発明の効果】本発明により、アルミニウム由来の収斂
味が改善され、かつ、経時的にもマスキング効果が低減
し難い水酸化アルミニウム配合経口液剤を提供する事が
できた。According to the present invention, it is possible to provide an oral solution containing aluminum hydroxide in which the astringent taste derived from aluminum is improved and the masking effect is hardly reduced with time.
【0017】[0017]
【実施例】以下、実施例および試験例により本発明をさ
らに詳細に説明する。なお、実施例で用いたシャンペン
サイダー香料は実質香気成分1.0重量%のものを用い
た。The present invention will be described in more detail with reference to the following Examples and Test Examples. The champagne cider fragrance used in the examples had a substantial odor component of 1.0% by weight.
【0018】実施例1 水酸化アルミニウムゲル 60g 水酸化マグネシウム 4g サッカリンナトリウム 0.06g シャンペンサイダー香料 0.1g 精製水 全量100mL 上記処方を混合し、塩酸にてpH=7.5に調節し懸濁
液剤を得た。Example 1 Aluminum hydroxide gel 60 g Magnesium hydroxide 4 g Saccharin sodium 0.06 g Champagne cider flavor 0.1 g Purified water A total of 100 mL The above formulations were mixed and adjusted to pH = 7.5 with hydrochloric acid to prepare a suspension. Obtained.
【0019】比較例1 実施例1の処方の香料をシナモン系香料に変更して実施
例1と同様にして比較用液剤を製造した。Comparative Example 1 A comparative liquid preparation was produced in the same manner as in Example 1 except that the fragrance of the formulation of Example 1 was changed to a cinnamon-based fragrance.
【0020】比較例2 実施例1の処方の香料をジンジャー系香料に変更して実
施例1と同様にして比較用液剤を製造した。Comparative Example 2 A comparative liquid preparation was produced in the same manner as in Example 1 except that the flavor of the formulation of Example 1 was changed to a ginger-based flavor.
【0021】比較例3 実施例1の処方の香料をミント系香料に変更して実施例
1と同様にして比較用液剤を製造した。Comparative Example 3 A comparative liquid preparation was prepared in the same manner as in Example 1 except that the fragrance of the formulation of Example 1 was changed to a mint-based fragrance.
【0022】比較例4 実施例1の処方の香料をヨーグルト系香料に変更して実
施例1と同様にして比較用液剤を製造した。Comparative Example 4 A comparative liquid preparation was produced in the same manner as in Example 1 except that the flavor of the formulation of Example 1 was changed to a yogurt-based flavor.
【0023】比較例5 実施例1の処方の香料をレモン系香料に変更して実施例
1と同様にして比較用液剤を製造した。Comparative Example 5 A comparative liquid preparation was produced in the same manner as in Example 1 except that the flavor in the formulation of Example 1 was changed to a lemon-based flavor.
【0024】比較例6 実施例1の処方の香料をハーバルミント系香料に変更し
て実施例1と同様にして比較用液剤を製造した。Comparative Example 6 A comparative liquid preparation was produced in the same manner as in Example 1 except that the flavor of the formulation of Example 1 was changed to a herbal mint flavor.
【0025】試験例1 実施例および比較例で製造した液剤について、それぞれ
15名の専門パネルにより収斂味の程度について官能試
験を実施し、二元配置法により評価した。Test Example 1 The liquid preparations produced in the Examples and Comparative Examples were subjected to a sensory test for the degree of astringency by a panel of 15 persons, and evaluated by the two-way arrangement method.
【0026】マスキング効果の評価は、以下の4段階で
行った。The evaluation of the masking effect was performed in the following four stages.
【0027】3:ほとんど収斂味を感じずに飲みやす
い。3: Easy to drink with almost no astringent taste.
【0028】2:やや不快な収斂味を感じるが服用に苦
痛や抵抗はない。2: Slightly unpleasant astringent taste is felt, but there is no pain or resistance in taking.
【0029】1:不快な収斂味を感じ飲みづらい。1: An unpleasant astringent taste is felt and it is hard to drink.
【0030】0:不快で強烈な収斂味を感じ、非常に飲
みづらい。0: Feels unpleasant and intense astringent taste, making it very difficult to drink.
【0031】各パネラーによる試験結果と平均ポイント
を表1に示した。Table 1 shows the test results and average points by each panelist.
【0032】[0032]
【表1】 [Table 1]
【0033】さらに試験例1の分散分析による解析結果
を表2に、サンプル間の有意差を図1に示した。図1中
の(*)は5%有意水準で実施例1が比較例2、5、6
よりも優れていることを意味している。Table 2 shows the results of the analysis of variance of Test Example 1 and FIG. 1 shows the significant difference between the samples. (*) In FIG. 1 is a 5% significance level and Example 1 is Comparative Examples 2, 5, and 6.
Means better than
【0034】[0034]
【表2】 [Table 2]
【0035】試験例2 実施例1および比較例5について、65℃にて3日間保
存したサンプルと室温保存サンプルを一組にして5名の
専門パネルにより一対比較法で水酸化アルミニウムの収
斂味の経時変化を以下の5段階で評価した。Test Example 2 For Example 1 and Comparative Example 5, a sample stored at 65 ° C. for 3 days and a sample stored at room temperature were paired, and the astringent taste of aluminum hydroxide was determined by a paired comparison method using a panel of five experts. The change with time was evaluated in the following five stages.
【0036】1:変化無し。1: No change.
【0037】2:変化の程度ははっきり判らない。2: The degree of change is not clearly understood.
【0038】3:どちらかというと変化している。3: Somewhat changed.
【0039】4:明らかに変化が認められる。4: A change is clearly observed.
【0040】5:かなりの変化が認められる。5: A considerable change is observed.
【0041】試験結果を表3に示した。The test results are shown in Table 3.
【0042】[0042]
【表3】 [Table 3]
【0043】全てのパネルがシャンペンサイダー系香料
は経時的なマスキング効果の変化の程度が少ないと評価
した。All the panels evaluated that the champagne cider fragrance had little change in the masking effect over time.
【0044】実施例2 水酸化アルミニウムゲル 56g 水酸化マグネシウム 4g サッカリンナトリウム 0.06g パラオオキシ安息香酸メチル 0.1g シャンペンサイダー系香料 0.1g pH調整剤(リン酸、塩酸) 適量 精製水 全量100mL pH=8 上記処方で実施例1と同様にして液剤を得た。Example 2 Aluminum hydroxide gel 56 g Magnesium hydroxide 4 g Saccharin sodium 0.06 g Methyl para-hydroxybenzoate 0.1 g Champagne cider-based flavor 0.1 g pH adjuster (phosphoric acid, hydrochloric acid) Appropriate amount Purified water 100 mL pH = 8 A liquid was obtained in the same manner as in Example 1 with the above formulation.
【0045】調製例2 水酸化アルミニウムゲル 60g 炭酸マグネシウム 5g サッカリンナトリウム 0.06g パラオオキシ安息香酸プロピル 0.1g シャンペンサイダー系香料 0.1g pH調整剤(リン酸、塩酸) 適量 精製水 全量100mL pH=8 上記処方で実施例1と同様にして液剤を得た。Preparation Example 2 Aluminum hydroxide gel 60 g Magnesium carbonate 5 g Sodium saccharin 0.06 g Propyl para-hydroxybenzoate 0.1 g Champagne cider-based flavor 0.1 g pH adjuster (phosphoric acid, hydrochloric acid) Appropriate amount Purified water 100 mL pH = 8 A liquid preparation was obtained in the same manner as in Example 1 with the formulation.
【図1】 試験例1のサンプル間の有意差についての図
である。FIG. 1 is a diagram showing a significant difference between samples of Test Example 1.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 小林 正樹 東京都豊島区高田3丁目24番1号 大正製 薬株式会社内 (72)発明者 富樫 美津雄 埼玉県大宮市三条町51番地 太田製薬株式 会社内 (72)発明者 佐野 勅美 埼玉県大宮市三条町51番地 太田製薬株式 会社内 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Masaki Kobayashi 3-24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Mitsugu Togashi 51 Sanjo-cho, Omiya-shi, Saitama Ota Pharmaceutical Co., Ltd. (72) Inventor Noriyoshi Sano 51, Sanjo-cho, Omiya City, Saitama Prefecture Ota Pharmaceutical Co., Ltd.
Claims (7)
料を含有することを特徴とする経口液剤。1. An oral liquid preparation comprising aluminum hydroxide and a cider-based flavor.
に記載の経口液剤。2. The method according to claim 1, wherein the pH value is in the range of 6-9.
The oral liquid preparation according to the above.
香気成分を中心とし、さらに(B)フルフラール、
(C)Allyl Caproate、Amyl Butyrate、Benzyl Acetat
e、Ethyl Acetate、Ethyl Acetoacetate、Ethyl Butyra
te、Ethyl Caproate、Hexyl Acetate、Isoamyl Acetate
およびMethyl Anthranilateからなる群から選ばれる1
種または2種以上、ならびに(D)カテキン、エピカテ
キン、プロトカテキン酸、カルコン、ケイヒ酸またはそ
の誘導体、3,4,5-Trihydroxybenzoicacid、バニリン、
バニリン酸、3,5-Dimetoxy-4-hydroxybenzoicacidおよ
び3,5-Dimetoxy-4-hydroxybenzaldehydeからなる群から
選ばれる1種または2種以上、を含有するものである請
求項1または2に記載の経口液剤。3. A cider-based fragrance comprising (A) a citrus-based fragrance component, (B) furfural,
(C) Allyl Caproate, Amyl Butyrate, Benzyl Acetat
e, Ethyl Acetate, Ethyl Acetoacetate, Ethyl Butyra
te, Ethyl Caproate, Hexyl Acetate, Isoamyl Acetate
1 selected from the group consisting of and Methyl Anthranilate
Species or two or more, and (D) catechin, epicatechin, protocatechinic acid, chalcone, cinnamic acid or a derivative thereof, 3,4,5-Trihydroxybenzoicacid, vanillin,
The oral composition according to claim 1 or 2, wherein the composition contains one or more selected from the group consisting of vanillic acid, 3,5-Dimetoxy-4-hydroxybenzoicacid and 3,5-Dimetoxy-4-hydroxybenzaldehyde. Liquid.
およびオレンジから選ばれる少なくとも1種である請求
項3記載の経口液剤。4. The oral liquid preparation according to claim 3, wherein the citrus flavor component is at least one selected from lemon, lime and orange.
いて、風味改善剤としてサイダー系香料を配合したこと
を特徴とする経口液剤。5. An oral liquid preparation comprising aluminum hydroxide and a cider-based flavor as a flavor improving agent.
化アルミニウムの不快風味改善剤。6. An unpleasant flavor improving agent for aluminum hydroxide, comprising a cider-based flavor as an active ingredient.
する水酸化アルミニウムの不快風味改善方法。7. A method for improving the unpleasant taste of aluminum hydroxide, which comprises adding a cider-based flavor.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10117652A JPH11310524A (en) | 1998-04-28 | 1998-04-28 | Oral liquid preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10117652A JPH11310524A (en) | 1998-04-28 | 1998-04-28 | Oral liquid preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11310524A true JPH11310524A (en) | 1999-11-09 |
Family
ID=14716982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10117652A Pending JPH11310524A (en) | 1998-04-28 | 1998-04-28 | Oral liquid preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH11310524A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016104367A1 (en) * | 2014-12-22 | 2016-06-30 | 株式会社Lttバイオファーマ | Functional dyspepsia therapeutic drug |
WO2016196205A1 (en) * | 2015-05-29 | 2016-12-08 | Johnson & Johnson Consumer Inc. | Use of organic citrus extract with high antimicrobial capacity as a preservative system in liquids, emulsions, suspensions, creams and antacids |
-
1998
- 1998-04-28 JP JP10117652A patent/JPH11310524A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016104367A1 (en) * | 2014-12-22 | 2016-06-30 | 株式会社Lttバイオファーマ | Functional dyspepsia therapeutic drug |
WO2016196205A1 (en) * | 2015-05-29 | 2016-12-08 | Johnson & Johnson Consumer Inc. | Use of organic citrus extract with high antimicrobial capacity as a preservative system in liquids, emulsions, suspensions, creams and antacids |
CN107683145A (en) * | 2015-05-29 | 2018-02-09 | 强生消费者公司 | Purposes of organic citrus extract as the preservative system in liquid, emulsion, suspension, creams and antiacid with high antimicrobial ability |
RU2714879C2 (en) * | 2015-05-29 | 2020-02-20 | Джонсон энд Джонсон Консьюмер Инк. | Use of organic extract of citrus fruits with high antimicrobial activity as system of preserving agents in liquids, emulsions, suspensions, creams and antacids |
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