JPH11299884A - Hollow fiber membrane type material exchanger - Google Patents

Abstract

PROBLEM TO BE SOLVED: To make it possible to obtain a required flow rate without blood damage with a small size and to improve oxygenation, decarburization gas performance, gas exchange efficiency, etc. by forming a barrier between a hollow fiber membrane process chamber and a pump chamber, forming a fluid flow hole at one end in a horizontal of the hollow fiber membrane process chamber and a liquid discharge part at the other end, respectively. SOLUTION: The barrier 105 is formed between the hollow fiber membrane process chamber 102 holding many hollow fibers 101 of the cylindrical hollow fiber membrane process part 100 and the pump chamber installed with rotary vanes of a centrifugal pump part 20. Further, the liquid flow hole 108 for passing liquid from the pump chamber to the hollow fiber membrane process chamber 102 is formed at one end in the horizontal direction of the hollow fiber membrane process chamber 102. The liquid discharge part for discharging the liquid in the hollow fiber membrane process chamber 102 is formed at the other end of the horizontal direction. Gas exchange may be sufficiently executed and unnecessary stagnation may be prevented by this constitution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hollow fiber membrane type material exchange apparatus which can be suitably used for an artificial lung and the like in which a pump is integrated.

[0002]

2. Description of the Related Art Hollow fiber membrane type material exchange devices are known in the field of artificial lungs and the like because they can easily perform mass exchange such as gas exchange through hollow fiber membranes.

For example, Japanese Patent Application Laid-Open No. Hei 5-177117 discloses a hollow fiber membrane type material exchange apparatus in which a pump is integrated and the apparatus is miniaturized. A hollow fiber membrane type mass exchange apparatus in which rotors are directly arranged is described. However, simply arranging the hollow fiber membrane in a cylindrical shape and simply arranging and rotating the rotor of the pump inside the hollow fiber membrane results in extremely poor pump efficiency, making it difficult to obtain a sufficient blood flow rate. As a result, in order to obtain the required flow rate, the rotating blades need to be rotated at a high speed, causing significant hemolysis of the blood, which is extremely undesirable. In addition, the artificial lung using the conventional pump-integrated hollow fiber membrane material exchange apparatus having no partition in the gas exchange section in which the rotor blades and the hollow fibers are arranged has a low gas exchange performance and is not satisfactory in practical use.

[0004]

SUMMARY OF THE INVENTION The present invention, particularly for application to an artificial lung, integrates a pump and reduces the size of the device, exhibits a sufficient pump function, and can be easily performed without damaging blood. Efficient gas exchange to the blood without the required flow rate being obtained and the insufficiently oxygenated and decarboxylated gas being discharged and the blood not being inadvertently retained in the device The present invention provides a hollow fiber membrane type material exchange device which can reduce the blood hemolysis.

[0005]

SUMMARY OF THE INVENTION The present invention relates to a hollow fiber membrane type material exchange apparatus having a cylindrical hollow fiber membrane processing section and a centrifugal pump provided inside the cylindrical hollow fiber membrane processing section. The hollow cylindrical fiber processing unit has a hollow fiber membrane processing chamber in which a large number of hollow fibers are held, and the centrifugal pump unit has a pump chamber in which rotary blades are installed. A partition is formed between the hollow fiber membrane processing chamber and a liquid flow hole through which liquid flows from the pump chamber to the hollow fiber membrane processing chamber is formed at one end in the horizontal direction of the hollow fiber membrane processing chamber. The present invention relates to a hollow fiber membrane type material exchange device, characterized in that a liquid discharge part from which the liquid is discharged is formed at the other end in the horizontal direction of the hollow fiber membrane processing chamber.

According to the present invention, a tubular hollow fiber membrane processing section has a tubular outer shell having an upper end and a lower end closed, and the tubular outer shell comprises an outer tubular portion, an inner tubular portion, an upper annular portion, The hollow fiber, wherein the hollow fiber is formed by a lower annular portion, and a partition between the hollow fiber membrane processing chamber and the pump chamber is formed by an inner cylindrical portion forming a cylindrical outer shell, and a liquid flow hole is formed in the partition. The present invention relates to a membrane type mass exchange apparatus.

According to the present invention, the tubular hollow fiber membrane processing section has an upper sealing wall formed at a position one step lower from the upper end and a lower sealing wall formed at a position one step higher from the lower end, A hollow fiber having a gas circulation part above the upper sealing wall and a gas circulation part below the lower sealing wall, and a number of hollow fibers held between the upper sealing wall and the lower sealing wall The present invention relates to the hollow fiber membrane type material exchange apparatus in which a membrane processing chamber is formed.

[0008] The present invention relates to the hollow fiber membrane type material exchange apparatus, wherein a horizontal rib is formed in the hollow fiber membrane processing chamber from the inner cylindrical portion toward the interior. The present invention relates to the hollow fiber membrane type material exchange apparatus in which horizontal ribs are formed in the hollow fiber membrane processing chamber from the outer cylinder toward the interior.

[0009] The present invention relates to the above-mentioned hollow fiber membrane type mass exchange apparatus in which a liquid introduction part is formed in a ceiling part of a pump room. The present invention provides the hollow fiber membrane, wherein a horizontal floor portion is formed in the pump chamber, a drive shaft rotatably projecting upward from a center portion of the horizontal floor portion, and a rotary wing attached to the drive shaft. The present invention relates to a mold material exchange device.

[0010] The present invention relates to the hollow fiber membrane type material exchange apparatus having a pump drive section for driving a drive shaft below a horizontal floor. The present invention provides the hollow fiber membrane type including a rotor having a built-in magnet in which a pump driving unit is fixed to a driving shaft, a magnet opposing the magnet, and a driving unit having a motor for rotating the opposing magnet. It relates to a mass exchange device.

According to the present invention, the main unit of the hollow fiber membrane type material exchange device is constituted by integrating the cylindrical hollow fiber membrane processing section, the pump chamber of the centrifugal pump section and the like. The present invention relates to the hollow fiber membrane type material exchange device in which a driving unit is detachable from the unit.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of a hollow fiber membrane type material exchange apparatus according to the present invention will be described below with reference to the drawings.

FIG. 1 is a perspective view showing an example of a main unit of the hollow fiber membrane type material exchange apparatus in the hollow fiber membrane type material exchange apparatus according to the present invention, and FIG. 2 is a hollow fiber membrane shown in FIG. FIG. 3 is a partially cutaway perspective view of a main part unit of the mold material exchange device. FIG. 3 is a partially cutaway exploded perspective view of the hollow fiber membrane type material exchange device main part unit shown in FIG. 1 with the hollow fiber membrane removed. FIG. 4 is a plan view of the main unit of the hollow fiber membrane type material exchange apparatus shown in FIG. 1 in a state where the rotors and the like of the centrifugal pump are removed, and FIG. 5 is shown in FIG. It is a front view of a state in which a rotary blade and the like of a centrifugal pump section are removed in a main unit of the hollow fiber membrane type material exchange device,
FIG. 6 is a side view of the main unit of the hollow fiber membrane type material exchange device shown in FIG. 1 with the centrifugal pump part removed from the rotating blades and the like. FIG. 7 is a side view of the hollow fiber membrane type material exchange device shown in FIG. FIG. 8 is a bottom view of the main unit of the mass exchange apparatus in a state where the rotor blades and the like of the centrifugal pump are removed, FIG. 8 is a cross-sectional view along line AA in FIG. 4, and FIG. 6 is a sectional view taken along the line BB in FIG. 6, FIG. 10 is a sectional view taken along the line CC in FIG. 6, and FIG. 11 is a hollow fiber membrane type material exchange shown in FIG. FIG. 12 is a plan view showing a state in which the ceiling of the pump chamber is transparent in the main unit of the apparatus, FIG. 12 is a cross-sectional view of the main unit of the hollow fiber membrane type material exchange apparatus shown in FIG. 1, and FIG. 4 shows the relationship between the blood flow rate in Example 1 and Comparative Example 1 and the ability to oxygenate blood per unit area of the hollow fiber membrane. A rough, FIG. 14 is a graph showing the hemolysis amount of time variation at the time of circulation perfused with blood flow rate 2.5 liters / min In Example 1 and Comparative Example 1.

The present invention provides a tubular hollow fiber membrane processing section 100,
In a hollow fiber membrane type material exchange apparatus having a centrifugal pump section 200 provided inside the tubular hollow fiber membrane processing section 100, the tubular hollow fiber membrane processing section 100 holds a large number of hollow fibers 101. Pump chamber 2 having a hollow fiber membrane processing chamber 102 and a centrifugal pump 200
02, the partition wall 105 is formed between the hollow fiber membrane processing chamber 102 and the pump chamber 202, and the liquid flow hole 10 through which the liquid flows from the pump chamber 202 to the hollow fiber membrane processing chamber 102.
8 is formed at one end of the hollow fiber membrane processing chamber 102 in the horizontal direction, and a liquid discharge part 109 for discharging liquid from the hollow fiber membrane processing chamber 102 is formed at the other end of the hollow fiber membrane processing chamber 102 in the horizontal direction. The present invention relates to a hollow fiber membrane type material exchange device characterized in that:

In the hollow fiber membrane type material exchange apparatus according to the present invention, the cylindrical hollow fiber membrane processing section 100 has a cylindrical outer shell 103 having closed upper and lower ends. 103
Is composed of an outer tubular portion 104, an inner tubular portion 105, an upper annular portion 106 and a lower annular portion 107, and a cylindrical outer shell 103
The hollow fiber membrane processing chamber 102 is
A partition 105 is formed between the hollow fiber membrane treatment chamber 102 and the pump chamber 202.
A liquid flow hole 108 through which liquid flows from the pump chamber 202 to the hollow fiber membrane processing chamber 102 is formed in the hollow fiber membrane processing chamber 102 at the other end of the hollow fiber membrane processing chamber 102 in the horizontal direction. The liquid discharge unit 10 from which the liquid is discharged from 102
9 are formed.

In the hollow fiber membrane type material exchange apparatus according to the present invention, the tubular hollow fiber membrane processing section 100 has an upper sealing wall 110 formed at a position one step lower from the upper end and rises one step from the lower end. Lower sealing wall 1 formed at position
11 and a gas flow portion 11 above the upper sealing wall 110.
2 and a gas flow portion 113 below the lower sealing wall 111, and the upper sealing wall 110 and the lower sealing wall 111
A hollow fiber membrane processing chamber 102 in which a large number of hollow fibers 101 are held is formed.

As the hollow fiber 101, for example, poly (4-
Hollow fibers made of methyl-1-pentene), poly (3-methyl-1-butene), polyethylene, polypropylene and the like can be used, and hollow fibers made of poly (4-methyl-1-pentene) are particularly preferable. preferable. Hollow fiber 101
Has an outer diameter of 90 to 480 μm and an inner diameter of 60 to 400 μm.
m, the film thickness is 15 to 80 μm, and it is preferable to use it by weaving it with a warp yarn such as a polyester yarn in a cord shape.

As the sealing resin forming the upper sealing wall 110 and the lower sealing wall 111, for example, polyurethane resin,
Epoxy resin, silicone and the like can be used.
The upper sealing wall 110 and the lower sealing wall 111 are sealed with the ends of the hollow fibers 101 opened.
In the hollow fiber membrane processing chamber 102 between the upper sealing wall 110 and the lower sealing wall 111, the membrane area of the hollow fiber 101 may be appropriately set according to the application. For example, this device is applied to an artificial lung application. In this case, the film area is preferably 0.1 to ⁴ m ² .

In the hollow fiber membrane type material exchange apparatus according to the present invention, a horizontal rib 114 is formed in the hollow fiber membrane processing chamber 102 from the inner cylinder 105 toward the interior, and the outer cylinder 1
A horizontal rib 115 is formed from 04 toward the room.

In the hollow fiber membrane type material exchange apparatus according to the present invention, the centrifugal pump section 200 has a pump chamber 202 in which a rotating blade 201 is installed. The pump chamber 202 of the centrifugal pump section 200 has a ceiling section 204 provided with a liquid introduction section 203 and a horizontal floor section 205.
5 is provided with a rotatable drive shaft 206 penetrating through the center portion. The rotary wing 201 is attached to the drive shaft 206 above the horizontal floor 205 and the drive shaft 206 is mounted below the horizontal floor 205. A rotor 208 having a built-in magnet 207 is attached thereto.

The hollow fiber membrane type material exchange apparatus according to the present invention has a tubular hollow fiber membrane processing unit 1 as shown in FIGS.
00, pump chamber 202 of centrifugal pump section 200, drive shaft 2
06, a main unit of a hollow fiber membrane type material exchange device in which a rotor 208 or the like in which a magnet 207 is incorporated is integrated, and a magnet which can be detachably disposed below the main unit of the hollow fiber type material exchange device. It is preferable that the motor 207 includes a driving unit (not shown) having a magnet facing the 207 and a motor for rotating the magnet. The magnet of the driving unit, the magnet 207, By rotating the rotor 208, the drive shaft 206, and the like, the rotating blade 201 of the pump chamber 202 can be rotated. It is preferable that the rotation speed of the rotary blade 206 of the pump chamber 202 be 200 to 6000 rotations / minute.

In the hollow fiber membrane type material exchange device according to the present invention, the outer cylindrical portion 104, the inner cylindrical portion 105, the upper annular portion 10
6, lower annular part 107, ceiling part 204, horizontal floor part 20
5. The members such as the drive shaft 206, the rotary wing 201, and the rotor 208 can be formed of, for example, a synthetic resin such as polycarbonate, polysulfone, polypropylene, or polyethylene. The hollow fiber membrane type material exchange device according to the present invention can be constituted by bonding with an agent or the like.

In the hollow fiber membrane type mass exchange apparatus according to the present invention, the main unit of the hollow fiber membrane type mass exchange apparatus may be appropriately determined according to the application. 20cm, height 3 ~ 13cm
It is preferable that

The operation in the case of performing gas exchange using the hollow fiber membrane type material exchange device according to the present invention in an artificial lung will be described below. By rotating the rotor of the pump unit 202 by rotating the motor of the prime mover unit, blood is supplied from the liquid introduction unit 203 and oxygen is supplied from the gas circulation unit 112 at the same time. Liquid introduction section 203
Is supplied to the hollow fiber membrane processing chamber 102 from the liquid circulation hole 108 at one end in the horizontal direction of the hollow fiber membrane processing chamber 102 by the rotation of the rotary blade 201, and passes through the hollow fiber membrane processing chamber 102. The liquid is discharged from the liquid discharge portion 109 at the other end in the horizontal direction of the hollow fiber membrane processing chamber 102, and returned to the patient's body. In the hollow fiber membrane processing chamber 102, the blood passing through the hollow fiber membrane processing chamber 102 comes into contact with the hollow fiber 101, and oxygen is supplied from the inside of the hollow fiber 101 to which oxygen is supplied from the gas circulation unit 112. At the same time, carbon dioxide gas moves from the blood into the hollow fiber 101 to perform gas exchange. After the gas exchange is performed, the gas in the hollow fiber 101 is discharged to the outside from the gas circulation unit 113. The amount of blood supplied from the liquid introduction unit 203 is preferably set to 100 to 9 liters / minute. The amount of oxygen supplied from the gas circulation unit 112 may be adjusted as needed for the blood, and is preferably 0.5 to 8 times the weight of the blood flow. In the illustrated hollow fiber membrane type material exchange device,
Oxygen is supplied from above the upper sealing wall 110, and gas after gas exchange is discharged from below the lower sealing wall 111. Conversely, if necessary, the lower sealing wall 111 Oxygen may be supplied from below, and the gas after gas exchange may be discharged from above the upper sealing wall 110.

The case where the hollow fiber membrane type material exchange device according to the present invention is used for an artificial lung has been described above. However, the hollow fiber membrane type material exchange device according to the present invention is not merely an artificial lung but an auxiliary heart. It can also be used as an extracorporeal circulation device for open heart surgery and an organ perfusion storage device.

[0026]

EXAMPLE 1 A main unit of a hollow fiber membrane type material exchange apparatus shown in FIGS. 1 to 12 was prepared.

The main unit of the hollow fiber membrane type material exchange device had an outer diameter of 13 cm and a height of 7.5 cm. Outer cylinder part 104, inner cylinder part 105, upper annular part 106, lower annular part 107, ceiling part 204, horizontal floor part 205, drive shaft 2
06, the rotary blade 201, the rotor 208, and the like were formed of polycarbonate, and required portions were bonded with a polyurethane-based adhesive. The upper sealing wall 110 and the lower sealing wall 111 were formed of urethane resin.

A hollow fiber 101 made of poly (4-methyl-pentene-1) having an outer diameter of 250 μm and an inner diameter of 200 μm is used, and the number of hollow fibers 101 is about 20 / cm using polyester multifilaments as warps. It was woven in the shape of a blind. In the hollow fiber membrane processing chamber 102 between the upper sealing wall 110 and the lower sealing wall 111, the effective membrane area based on the outer diameter of the hollow fiber 101, which comes into contact with blood and exchanges gas, was about 1 m ² .

A driving unit (not shown) having a magnet opposed to the magnet 207 and a motor for rotating the magnet is disposed below the main unit of the hollow fiber membrane type material exchange apparatus to form a hollow unit according to the present invention. A membrane-type material exchange device was constructed.

Using this hollow fiber membrane type material exchange device,
Using fresh blood of cattle anticoagulated by CD,
AAMI (AMERICAN FOR THE ADOVANCEMEVNT OF MEDICA
The gas exchange performance of the present hollow fiber membrane substance exchange device into blood was measured according to the L INSTRUCTION) standard. Fig. 1 shows the relationship between blood flow and oxygenation capacity of blood per unit area of hollow fiber membrane.
3 is shown. FIG. 14 shows the time change of the hemolysis amount when circulating perfusion was performed at a blood flow rate of 2.5 L / min.

Comparative Example 1 A hollow fiber woven in the same manner as in Example 1 was used.
Approximately 1m of semi-effective membrane area ^TwoAnd JP-A-5-177117.
And hollow fiber woven in the same manner as in Example 1 described in
An artificial lung having a configuration in which no partition was provided between the wing and the wing was manufactured.
The length of the pump rotor in the vertical direction is the same as that of the hollow fiber.
The length was the same as the effective length. Fresh cow blood as in Example 1
Adjust the gas exchange capacity of the device and the hemolytic properties during hemoperfusion.
It was measured. The results are shown in FIGS. 13 and 14, respectively. Ma
In addition, in the artificial lung of this configuration, it exceeds 3 liter / min.
Blood flow is limited by the drive used in experiments
I could not get it even if I raised it to the world.

[0032]

When the hollow fiber membrane type substance exchange apparatus according to the present invention is applied to, for example, an artificial lung, the blood to be gas-exchanged flows from one end of the hollow fiber membrane processing chamber 102 in the horizontal direction to the hollow fiber membrane processing chamber. After the gas enters into the hollow fiber membrane processing chamber 102 and passes through the entire length of the hollow fiber membrane processing chamber 102 in the horizontal direction to perform gas exchange, the gas is discharged from the other end of the hollow fiber membrane processing chamber 102 in the horizontal direction.
The gas is not exhausted due to insufficient gas exchange, and does not accidentally stay in the apparatus.

Further, the hollow fiber membrane type material exchange device according to the present invention is provided with horizontal ribs 115 and 116 formed from the inner cylinder 105 and / or the outer cylinder 104 of the hollow fiber membrane processing chamber 102 toward the interior. By accurately fixing the hollow fiber 101 at a predetermined position in the hollow fiber membrane processing chamber 102, a sufficient space for blood to flow smoothly in the hollow fiber membrane processing chamber 102 can be secured. In addition, it eliminates the drift and stagnation of blood and realizes highly efficient gas exchange.

Further, the hollow fiber membrane type material exchange device according to the present invention is a main unit of the hollow fiber membrane type material exchange device in which a cylindrical hollow fiber membrane processing section, a pump chamber of a centrifugal pump section and the like are integrated. The cost unit can be reduced by making the driving unit unit detachable, disposing the main unit of the hollow fiber membrane type material exchange device in a disposable manner, and repeatedly using the driving unit unit.

[Brief description of the drawings]

FIG. 1 is a perspective view showing an example of a main unit of a hollow fiber membrane type material exchange device in a hollow fiber membrane type material exchange device according to the present invention.

FIG. 2 is a partially broken perspective view of a main unit of the hollow fiber membrane type material exchange device shown in FIG.

FIG. 3 is a partially exploded perspective view of the main unit of the hollow fiber membrane type mass exchange apparatus shown in FIG. 1 with the hollow fiber membrane removed.

FIG. 4 is a plan view of the main unit of the hollow fiber membrane type material exchange device shown in FIG. 1 with a centrifugal pump part from which rotors and the like are removed.

5 is a front view of the main unit of the hollow fiber membrane type material exchange apparatus shown in FIG. 1 in a state in which a rotary blade and the like of a centrifugal pump section are removed.

6 is a side view of the main unit of the hollow fiber membrane type material exchange apparatus shown in FIG. 1 in a state in which a rotary blade and the like of a centrifugal pump section are removed.

FIG. 7 is a bottom view of the main unit of the hollow fiber membrane type material exchange device shown in FIG. 1 with a centrifugal pump part from which rotary blades and the like are removed.

FIG. 8 is a sectional view taken along the line AA in FIG. 4;

FIG. 9 is a sectional view taken along line BB in FIG. 6;

FIG. 10 is a sectional view taken along line CC in FIG. 6;

11 is a plan view of the main unit of the hollow fiber membrane type material exchange device shown in FIG. 1 with the ceiling of the pump chamber being transparent.

FIG. 12 is a cross-sectional view of a main unit of the hollow fiber membrane type material exchange device shown in FIG.

FIG. 13 shows blood flow rates in Example 1 and Comparative Example 1,
It is a graph which shows the relationship with the oxygenation ability to blood per unit area of a hollow fiber membrane.

FIG. 14 shows blood flow in Example 1 and Comparative Example 1.
It is a graph which shows the time change of the hemolysis amount at the time of circulating perfusion at 5 l / min.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 100 Hollow fiber membrane processing part 101 Hollow fiber 102 Hollow fiber membrane processing chamber 103 Cylindrical outer shell 104 Outer cylinder 105 Inner cylinder 106 Upper annular part 107 Lower annular part 108 Liquid circulation hole 109 Liquid discharge part 110 Upper sealing wall 111 Lower sealing wall 112 Gas flow section 113 Gas flow section 114 Horizontal rib 115 Horizontal rib 200 Centrifugal pump section 201 Rotor blade 202 Pump chamber 203 Liquid introduction section 204 Ceiling section 205 Horizontal floor section 206 Drive shaft 207 Magnet 208 Rotor

Continuation of the front page (72) Inventor Takumi Yoda 1660-2-401, Sazu, Kurashiki-shi, Okayama Prefecture (72) Inventor Hisaki Takano 5-7-1, Fujishirodai, Suita-shi, Osaka, National Cardiovascular Center Research Institute (72) Inventor Yoshiyuki Myonaka 5-7-1, Fujishirodai, Suita-shi, Osaka, in the National Cardiovascular Center Research Institute (72) Inventor Eisuke Tatsumi 5-7-1, Fujishirodai, Suita-shi, Osaka, in the National Cardiovascular Center Research Institute

Claims (10)

[Claims] In a hollow fiber membrane type material exchange apparatus having a tubular hollow fiber membrane processing section and a centrifugal pump provided inside the tubular hollow fiber membrane processing section, a tubular hollow fiber membrane is provided. The processing section has a hollow fiber membrane processing chamber in which a large number of hollow fibers are held, and the centrifugal pump section has a pump chamber in which rotating blades are installed,
A partition is formed between the hollow fiber membrane processing chamber and the pump chamber, and a liquid circulation hole through which liquid flows from the pump chamber to the hollow fiber membrane processing chamber is formed at one end in the horizontal direction of the hollow fiber membrane processing chamber. A hollow fiber membrane type material exchange device, wherein a liquid discharge portion for discharging liquid from the hollow fiber membrane processing chamber is formed at the other end in the horizontal direction of the hollow fiber membrane processing chamber. 2. The tubular hollow fiber membrane treating section has a tubular outer shell having an upper end and a lower end closed, and the tubular outer shell comprises an outer tubular portion, an inner tubular portion, an upper annular portion, and a lower annular portion. The partition according to claim 1, wherein the partition is formed between the hollow fiber membrane processing chamber and the pump chamber by the inner cylindrical portion that forms the cylindrical outer shell body, and the partition has a liquid flow hole. Hollow fiber membrane type material exchange device. 3. The tubular hollow fiber membrane treating section has an upper sealing wall formed at a position one step lower from the upper end and a lower sealing wall formed at a position one step higher from the lower end,
A hollow fiber having a gas circulation part above the upper sealing wall and a gas circulation part below the lower sealing wall, and a number of hollow fibers held between the upper sealing wall and the lower sealing wall The hollow fiber membrane type material exchange apparatus according to claim 1 or 2, wherein a membrane treatment chamber is formed. 4. The hollow fiber membrane type material exchange apparatus according to claim 2, wherein a horizontal rib is formed in the hollow fiber membrane processing chamber from the inner cylindrical portion toward the interior. 5. The hollow fiber membrane type material exchange apparatus according to claim 2, wherein a horizontal rib is formed in the hollow fiber membrane processing chamber from the outer cylinder toward the interior. 6. The hollow fiber membrane type material exchange device according to claim 1, wherein a liquid introduction portion is formed in a ceiling portion of the pump chamber. 7. The pump chamber is formed with a horizontal floor, a drive shaft rotatably projecting upward from the center of the horizontal floor, and a rotary wing attached to the drive shaft. ,
Claim 2, Claim 3, Claim 4, Claim 5, or Claim 6
The hollow fiber membrane type substance exchange device according to the above. 8. The hollow fiber membrane type material exchange apparatus according to claim 7, further comprising a pump drive section for driving a drive shaft below the horizontal floor. 9. The pump drive unit according to claim 8, further comprising: a rotor having a built-in magnet fixed to the drive shaft, a motor opposing the magnet, and a motor unit having a motor for rotating the opposing magnet. Hollow fiber membrane type material exchange device. 10. The hollow fiber membrane processing unit, the pump chamber of the centrifugal pump unit and the like are integrated into a hollow fiber membrane type material exchange device main unit, and the hollow fiber membrane type material exchange device main unit is 10. The hollow fiber membrane type material exchange device according to claim 9, wherein the driving unit is detachable.