JPH1129426A - Antibacterial and antifungal agent and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antibacterial and antifungal agent excellent in the durability of weather resistance, heat resistance, safety and antimicrobial effect and useful for sterilizing and disinfecting drinking water, etc., by reducing an antimicrobial metal in a state carried on an inorganic carrier. SOLUTION: This antibacterial and antifungal agent is obtained by depositing (B) an antimicrobial metal such as silver or copper on (A) an inorganic carrier such as zeolite or activated carbon, reducing the carried component B and optionally further binding a silane coupling agent such as octadecyltrimethoxysillane or a silane coupling agent bound to an organic compound to the inorganic carrier. The deposition treatment is carried out e.g. by immersing 100 pts.wt. of the component A in a solution containing 0.1-20 pts.wt. of the ion of the component B and controlled to a pH of 6-8 at 10-35 deg.C for 1-6 hr. The reduction treatment is carried out e.g. by immersing the carrying carrier in a solution containing a reducing agent such as ascorbic acid in an amount of 0.0001-0.005 wt.% based on the weight of the carried component B. The objective antibacterial and antifungal agent is useful for controlling the proliferation of algae in water and for preventing the generation of fungi, etc., on resin products, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an antibacterial / antifungal agent and a method for producing the same.

[0002]

2. Description of the Related Art Organic and inorganic antibacterial agents are known as antibacterial and antifungal agents. Until now, organic antibacterial and antifungal agents having excellent immediate action have been widely used. However, organic antibacterial and antifungal agents are generally toxic and have serious problems in terms of safety. On the other hand, inorganic antibacterial and antifungal agents are slightly inferior to organic antibacterial and antifungal agents in terms of immediate effect, but are highly safe, and have excellent antibacterial action persistence and heat resistance. The use of inorganic antibacterial and antifungal agents has been greatly increasing.

It has been known that metals such as gold, silver, copper, and zinc have an antibacterial effect, and these metals (called antibacterial metals) are used as inorganic antibacterial and antifungal agents. Are used mainly. The mechanism by which these antimicrobial metals exert their antimicrobial action is not completely understood, but active oxygen generated by the catalytic action of metal ions kills bacteria,
Bacteria with negative ionicity, in which metal ions inhibit enzymes in the metabolic system of bacteria or attach to cell membranes and inhibit mass transfer, making cell division impossible and killing bacteria. And destroying and killing bacterial cell membranes.

As an application example of an antibacterial metal to an antibacterial and antifungal agent, it is known to use a silver nitrate solution as a disinfectant, an eye drop or the like. However, a liquid silver nitrate solution has a problem that the range of use is limited, and if the concentration is high, it is highly toxic and difficult to handle. On the other hand, as an antibacterial and antifungal agent in which an antibacterial metal is supported on a solid inorganic carrier, for example, a porous substance such as silica gel or activated carbon is used as a carrier,
A carrier in which silver or the like is supported thereon, a carrier in which silver or the like is supported using zeolite as a carrier (Japanese Patent No. 128654, JP-A-60-181002, etc.), or an inorganic oxoacid salt such as magnesium aluminate metasilicate is used as a carrier. An antibacterial metal ion such as silver ion-exchanged with a metal ion of a carrier and supported (JP-A-3-275627) is known.

[0005]

However, the conventional antibacterial and antifungal agents supported on the solid inorganic carrier also have various problems. For example, when a porous substance is used as a carrier, the metal retention power is weak, and when added to water, the rate of elution of the supported metal into water is high, and the antibacterial effect is reduced in a short period of time. There was a problem. In addition, the U.S. Public Health Service regulates the concentration of silver ions in water to be 50 ppb or less from the viewpoint of safety. However, when an antibacterial / antifungal agent using the above porous substance as a carrier is added to water, it is used. There was a risk that silver ions in an amount exceeding this safety standard value would elute. On the other hand, antibacterial and antifungal agents using zeolites and inorganic oxoacid salts as carriers have a lower metal elution rate into water than antibacterial and antifungal agents using porous materials as carriers, but have a sustained antibacterial effect. It was not always enough.

Further, in the case of an antibacterial / antifungal agent using zeolite as a carrier, there is a problem that the metal is oxidized and discolors to brown with time, and in particular, the discoloration becomes remarkable by light irradiation (weather resistance is low). , Used for antibacterial treatment of resin products,
When used to add antibacterial properties to paints, etc.,
There has been a problem that resin products are discolored due to discoloration of antibacterial and antifungal agents. In the case of an antibacterial / antifungal agent using an inorganic oxo acid salt as a carrier, weather resistance is higher than that of an antibacterial / antifungal agent using a zeolite as a carrier, but it is hard to say that it has sufficient weather resistance. When a resin product is subjected to antibacterial treatment, the resin material is heated to a temperature equal to or higher than the softening temperature to prevent
A method of kneading an antifungal agent may be adopted, but if the antibacterial / antifungal agent has low heat resistance, heat during kneading into the resin may cause the antibacterial / antifungal agent to discolor and reduce the product value. Therefore, conventional antibacterial and antifungal agents having an antibacterial metal supported on an inorganic carrier have not been said to have sufficient heat resistance.

In order to improve the heat resistance of an antibacterial and antifungal agent having an antibacterial metal supported on an inorganic carrier, a silver salt or the like is adsorbed on silica gel and calcined, followed by hydrolysis of a reactive organic silicon compound. (Japanese Patent Application Laid-Open No. 6-87711). However, when the silver salt or the like is calcined after being carried and adsorbed on silica gel, the carried silver is melted, and the silver becomes a neutral metal state (a so-called metal state having no charge) on the inorganic carrier, and is firmly fixed. Thus, elution of silver becomes difficult, and the antibacterial property may be reduced. On the other hand, if silica gel is not calcined, the retention of antibacterial metal such as silver carried thereon is weak, so conventionally it has to be calcined in order to increase the persistence of the antibacterial effect, and as a result, as described above, Problems could not be avoided.

[0008] The present invention has been made in view of the above points,
An object of the present invention is to provide an antibacterial / antifungal agent excellent in weather resistance, heat resistance and safety and excellent in persistence of antibacterial effect, and a method for producing the same.

[0009]

That is, the antibacterial and antifungal agent of the present invention is characterized in that an antibacterial metal is subjected to a reduction treatment in a state of being supported on an inorganic carrier. Antibacterial of the present invention
In the antifungal agent, a silane coupling agent and / or a silane coupling agent combined with an organic substance may be further bound to the inorganic carrier. The method for producing the antibacterial and antifungal agent of the present invention,
The method is characterized in that an inorganic carrier is brought into contact with an aqueous solution containing an antibacterial metal ion and then reduced. In the production method of the present invention, as the inorganic carrier to be brought into contact with an aqueous solution containing an antibacterial metal ion, a carrier to which a silane coupling agent and / or a silane coupling agent bound to an organic substance can be used. Before or after the reduction, a silane coupling agent and / or a silane coupling agent combined with an organic substance may be bound to the inorganic carrier.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, antibacterial metals include gold, silver, copper, zinc, mercury, bismuth, cadmium,
Cobalt, nickel and the like can be mentioned, and two or more of these may be supported on an inorganic carrier. Among these antibacterial metals, silver, copper and mercury are preferable, and silver and copper are particularly preferable.
Examples of the inorganic carrier on which the antibacterial metal is supported include porous materials having pores specific to the crystal structure (eg, zeolite, aluminophosphate, etc.), amorphous porous materials (eg, activated carbon, etc.), and porous secondary particles (eg, silica gel). ), Layered compound porous material (for example, layered viscous minerals such as kaolinite group and smectite group, crystalline tetravalent metal phosphate such as zirconium phosphate), and phase separation / elution type porous material (for example, porous glass etc.) ). Among these, zeolite, activated carbon, silica gel, layered clay mineral, and crystalline tetravalent metal phosphate are preferred.

The antibacterial and antifungal agent of the present invention is characterized in that an antibacterial metal carried on the above-mentioned inorganic carrier has been subjected to a reduction treatment. Without firing after supporting the metal,
The antibacterial effect has excellent durability. Antibacterial of the present invention
The antifungal agent can be obtained by bringing a solution containing an antibacterial metal ion into contact with an inorganic carrier and then reducing the solution.
The solution containing the antibacterial metal ion can be prepared by dissolving a water-soluble salt of the antibacterial metal in water. Further, in order to adjust the pH of the solution containing the antibacterial metal ion, a water-soluble salt of the antibacterial metal can be used by dissolving it in a phosphate buffer or the like. In producing the antibacterial and antifungal agent of the present invention, the solution containing the antibacterial metal ion is preferably adjusted to contain 0.1 to 20 parts by weight of the antibacterial metal per 100 parts by weight of the inorganic carrier. . Examples of the water-soluble salt of the antibacterial metal include a sulfate, a nitrate, a chloride, a hypochlorite, a chlorate, a perchlorate, a phosphate, and a hydroxide of the antibacterial metal. The solution containing the antibacterial metal ion preferably has a pH of 4 to 10, particularly preferably a pH of 6 to 8.

As a method of bringing the inorganic carrier into contact with a solution containing antibacterial metal ions, for example, a method of immersing the inorganic carrier in a solution containing antibacterial metal ions (hereinafter sometimes referred to as a treatment liquid) is used. No. In the method of immersing the inorganic carrier in the treatment liquid, it is preferable to immerse the treatment liquid at a treatment liquid temperature of 10 to 35 ° C for 1 to 6 hours. Further, a method of spraying a treatment solution containing an antibacterial metal ion onto an inorganic carrier can also be adopted.

Next, the inorganic carrier brought into contact with the solution containing the antibacterial metal ion is treated with a reducing agent. For the reduction treatment, it is possible to adopt a method such as immersing the inorganic carrier brought into contact with the solution containing the antibacterial metal ion into the solution containing the reducing agent, or spraying the solution containing the reducing agent onto the inorganic carrier. it can. As a reducing agent, ascorbic acid or a relatively unstable hydrogen compound such as hydrogen peroxide, hydrogen, hydrogen iodide, hydrogen sulfide or lithium aluminum hydride, or a lower oxidant such as carbon monoxide, sulfur dioxide or sulfite is used. Products or salts of lower oxides, sulfur compounds such as sodium sulfide, sodium polysulfide, ammonium sulfide, highly electropositive metals such as alkali metals, magnesium, calcium, aluminum, zinc, etc. or amalgams thereof, or low valence state Metal salts, aldehydes, saccharides, organic compounds such as formic acid, oxalic acid, etc. can be used.

The solution containing the reducing agent is prepared such that the concentration of the reducing agent is equal to or less than the amount of the metal supported on the inorganic carrier, and more preferably, based on the weight of the metal supported on the inorganic carrier. It is preferable to use one prepared so as to contain 0.0001 to 0.005% by weight of a reducing agent. In the antibacterial and antifungal agent of the present invention, the antibacterial metal supported on the inorganic carrier is ionic, neutral metal-like, oxide, hydroxide, depending on the difference in the holding state after being supported.
It is thought that it exists in various states such as a complex compound.
However, the antibacterial and antifungal agent of the present invention, even if the supported metal is in a neutral metal form, such as those baked after supporting the antibacterial metal on the inorganic carrier, the antibacterial metal on the inorganic carrier. Since it is not firmly fixed, there is no possibility that the antibacterial effect is reduced.

In the antibacterial and antifungal agent of the present invention, a silane coupling agent represented by the following formula (1) may be further bound to an inorganic carrier. When the silane coupling agent is bonded, the durability of the antibacterial effect is further improved, and when the antibacterial and antifungal agent is kneaded into the resin and used, the dispersibility in the resin is also improved.

[0016]

Embedded image RSix ₃ ... (1)

In the above formula (1), R represents an organic functional group containing, for example, a vinyl group, an amino group, a halogeno group, a hydroxyl group, a thiol group, a ureido group, an epoxy group, a methacryloyl group, an epoxycyclohexyl group, an alkyl group and a polyether group. X is, for example, a halogen, an alkoxy group,
Shows a hydrolyzable group such as a keto group.

Specific examples of the silane coupling agent include, for example, γ- (2-aminoethyl) aminopropyltrimethoxysilane, γ- (2-aminoethyl) aminopropylmethyldimethoxysilane, γ-methacryloxypropyltrimethoxysilane Silane, N-β- (N-vinylbenzylaminoethyl) -γ-aminopropyltrimethoxysilane hydrochloride, γ-glycidoxypropyltrimethoxysilane, γ-mercaptopropyltrimethoxysilane,
Methyltrimethoxysilane, methyltriethoxysilane, vinyltriacetoxysilane, γ-chloropropyltrimethoxysilane, hexamethyldisilazane, γ-aminopropyltrimethoxysilane, vinyltrimethoxysilane, dimethyldimethoxysilane, octadecyldimethyl (3- (Trimethoxysilyl) propyl) ammonium chloride, γ-mercaptopropylmethyldimethoxysilane, hydroxypropyltrimethoxysilane,
γ-ureidopropyltriethoxysilane, γ-dibutylaminopropyltrimethoxysilane, phenyltrimethoxysilane, dimethyldiethoxysilane, trimethylmethoxysilane, n-decyltrimethoxysilane, isobutyltrimethoxysilane, trimethylethoxysilane, γ-diallyl Aminopropyltrimethoxysilane,
Examples include n-hexadecyltrimethoxysilane, n-octadecyltrimethoxysilane, and γ-methacryloxypropylmethyldimethoxysilane. These silane coupling agents can be used as a mixture of two or more kinds.

In order to further enhance the dispersibility of the antibacterial and antifungal agent of the present invention in a resin and to enhance the stability of the antibacterial and antifungal agent, for example, the stability against ultraviolet rays and oxidation, the silane bonded to the inorganic carrier can be used. It is preferable that an organic substance is further bound to the coupling agent.

The organic substance that can be combined with the silane coupling agent differs depending on the type of R in the above formula (1). For example, when R is a functional group containing an amino group, examples of the organic substance that can be bound include monohalogenated carboxylic acids and carboxylic acids, and when R is a functional group containing an epoxy group, the organic substance that can be bound is Examples thereof include carboxylic acids, alcohols, and amines. When R is a functional group containing a hydroxyl group or a thiol group, examples of the bondable organic substance include carboxylic acids and alcohols.

What kind of organic substance is bonded to the silane coupling agent may be selected in consideration of the dispersibility and the like according to the type of the resin to which the antibacterial / antifungal agent is to be added. The silane coupling agent is an inorganic carrier 100
It is preferable to react 0.01 to 10 parts by weight per part by weight. It is preferable that 0.001 to 1.0 part by weight of the organic substance is reacted with respect to 100 parts by weight of the silane coupling agent.

A silane coupling agent and / or
Or when bonding a silane coupling agent bonded to an organic substance, the silane coupling agent and / or the silane coupling agent bonded to an organic substance may be bonded to the inorganic carrier before supporting the antibacterial metal on the inorganic carrier, It may be bound after being supported, or may be bound before reduction,
You may couple | bond after reducing.

When the antibacterial and antifungal agent of the present invention comes in contact with water, a very small amount of antibacterial metal ions elute in the water, and the eluted antibacterial metal ions kill bacteria in the water, Since a small amount of antibacterial metal ions remain, the subsequent propagation of bacteria is also prevented.
Further, when the antibacterial and antifungal agent of the present invention contains water, the antibacterial metal ions are eluted in the water content,
Bacteria that come into contact with the antifungal agent die. Further, even when the antibacterial and antifungal agent of the present invention is used in an anhydrous state, the cells of the bacteria contain water, so that the bacteria can be treated with the antibacterial and antifungal of the present invention.
Upon contact with an antifungal agent, antibacterial metal ions are eluted into bacterial cells and can kill the bacteria.

The antibacterial and antifungal agents of the present invention can be used, for example, to disinfect drinking water, inhibit the growth of algae in water, prevent mold from forming on resin products, prevent barnacles from adhering to ship bottoms, and contaminate dogs and cats with manure. For the purpose of prevention, etc., water and resin products can be used by antibacterial treatment, added to paint such as ship bottom paint, or added to sand that may be contaminated by dog and cat manure. It is possible to suppress the death, generation, and proliferation of bacteria, bacteria, molds, and microorganisms, but it is not limited to these applications.

As a method for carrying out the antibacterial treatment of water with the antibacterial / antifungal agent of the present invention, water can be passed through a column filled with the antibacterial / antifungal agent of the present invention, or the antibacterial / antifungal agent of the present invention can be used in water. An immersion method and the like can be mentioned. When used for antibacterial treatment of a resin product, for example, a method of kneading the antibacterial and antifungal agent of the present invention into a raw material resin can be adopted. As the resin for kneading the antibacterial and antifungal agents, any resin having plasticity may be used. For example, polyethylene, polypropylene, polystyrene, ABS resin, polyvinyl chloride,
MMA resin and the like can be mentioned. The amount of the antibacterial / antifungal agent added to the resin is determined in consideration of the kneading efficiency, antibacterial performance, resin strength and the like.

The resin into which the antibacterial and antifungal agent has been kneaded can be formed into an arbitrary form such as a sphere, a pellet, a plate, a sheet, and a fiber. For example, in the case of plate, sheet, fiber, etc., the antibacterial / antifungal agent and the resin are premixed,
A method in which the resin is kneaded in a kneading machine such as an extruder at a temperature equal to or higher than the softening temperature of the resin and then extruded from a die or the like into a sheet, plate, fiber or the like is employed. The spherical or pellet resin into which the antibacterial / antifungal agent is kneaded can be made into an antibacterial resin product having a predetermined shape by injection molding.

After the antibacterial and antifungal agent of the present invention is applied to the surface of a resin product, an antibacterial resin product can be obtained by heat-pressing the applied surface.

When the antibacterial / antifungal agent of the present invention is added to paints such as ship bottom paints, the paints may be oily or water-based, and are blended in the same manner as pigments. What is necessary is just to mix | blend and mix an antifungal agent.

[0029]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples. The antibacterial and antifungal agents used in the following Examples and Comparative Examples were produced as follows.

Antibacterial and antifungal agent A (product of the present invention) 100 g of zeolite was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, stirred at room temperature for 1 hour, and then 3.2 g of silver nitrate Was added and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. This filtrate is mixed with ascorbic acid 0.0
1 liter of a 0033% by weight aqueous solution
After stirring for an hour, the mixture was filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent A.

Antibacterial and antifungal agent B (product of the present invention) 100 g of kaolin was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, stirred at room temperature for 1 hour, and then 3.2 g of silver nitrate Was added and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. The filtrate is ascorbic acid 0.00
The solution was added to 1 liter of a 4% by weight aqueous solution, stirred at room temperature for 1 hour, and then filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent B.

Antibacterial / antifungal agent C (product of the present invention) 100 g of kaolin was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate and stirred at room temperature for 1 hour, followed by 3.2 g of silver nitrate Was added and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. The filtrate is ascorbic acid 0.00
It was added to 1 liter of a 033% by weight aqueous solution, stirred at room temperature for 1 hour, and then filtered. The filtrate was placed in 1 liter of ion-exchanged water to which 1 g of octadecyltrimethoxysilane was added, stirred at 80 ° C. for 1 hour, washed with acetone, and filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent C.

Antibacterial / antifungal agent D (product of the present invention) 100 g of zeolite was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, and the mixture was stirred at room temperature for 1 hour. Was added and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. This filtrate is treated with 0.001 hydrogen peroxide.
It was added to 1 liter of a 1% by weight aqueous solution, stirred at room temperature for 1 hour, and then filtered. The filtrate was placed in 1 liter of ion-exchanged water to which 1 g of γ-aminopropyltriethoxysilane was added, stirred at 80 ° C. for 1 hour, washed with acetone, and filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent D.

Antimicrobial / antifungal agent E (product of the present invention) 100 g of zeolite was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate and stirred at room temperature for 1 hour, and then 3.2 g of silver nitrate Was added and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. This filtrate is mixed with ascorbic acid 0.0
1 liter of a 0033% by weight aqueous solution
After stirring for an hour, the mixture was filtered. The filtrate was placed in 1 liter of ion-exchanged water to which 1 g of hydroxypropyltrimethoxysilane was added, stirred at 80 ° C. for 1 hour, washed with acetone, and filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent E.

Antibacterial / antifungal agent F (comparative) 100 g of zeolite was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, stirred at room temperature for 1 hour, and 3.2 g of silver nitrate was added. After the addition and stirring at room temperature for 1 hour, the mixture was filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent F.

Antibacterial / antifungal agent G (comparative product) 100 g of kaolin was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, stirred at room temperature for 1 hour, and 3.2 g of silver nitrate was added. After the addition and stirring at room temperature for 1 hour, the mixture was filtered. The filtrate was added to 1 liter of a 0.7% aqueous solution of sodium phosphate dodecahydrate, 45.5 g of zinc nitrate hexahydrate was added with stirring, and the mixture was stirred at room temperature for 1 hour and filtered. The filtrate was dried under reduced pressure at 250 ° C. for 1 day to obtain an antibacterial / antifungal agent G.

Examples 1 to 5 and Comparative Examples 1 and 2 2 g of an antibacterial and antifungal agent was kneaded into 100 g of a resin, and then formed into a sheet having a thickness of 2 mm.
A 4 mm × 64 mm sample was prepared. As the resin to be kneaded, two types of polyethylene (PE) and ABS were used. The coloring due to heat when kneading the antibacterial / antifungal agent into the resin was visually observed, and the heat resistance was evaluated according to the following criteria in comparison with a blank containing no antibacterial / antifungal agent. Table 1 shows the results.

Evaluation criteria for heat resistance ・: Equivalent to blank (no antibacterial / antifungal agent added) Δ: Slightly colored compared to blank. ×: considerably colored compared to blank.

Further, the samples prepared as described above were tested for weather resistance and antibacterial property by ultraviolet irradiation. The weather resistance was evaluated by irradiating the sample with an ultraviolet ray for 24 hours using an ultraviolet lamp, observing the change in the color tone of the sample with the naked eye, and comparing it with a blank containing no antibacterial and antifungal agent according to the following criteria. Table 1 shows the results. For antibacterial activity, put the above sample in a sterile petri dish, drop 0.5 ml of Escherichia coli suspension on it, then adhere a sterile polyethylene film to the sample surface and culture at 35 ° C and 90% or more humidity for 24 hours. After that, SCLP medium 10
The bacterial solution was washed out in a sterile petri dish with milliliters, and then washed three times with a Komagome pipette onto the polyethylene film and the sample surface, and the viable bacteria washed out in the washing solution were diluted with a standard agar medium for agar dilution plating. And the result of measurement of the number of viable cells was shown. The results are shown in Table 1.

Evaluation criteria for weather resistance ○: Color tone equivalent to blank (no antibacterial / antifungal agent added) △ ・ ・ There is a slight change in the color tone compared to the blank. X: There is a considerable change in the color tone as compared to the blank.

[0041]

[Table 1]

[0042]

As described above, the antibacterial / antifungal agent of the present invention elutes the supported antibacterial metal over a long period of time in trace amounts necessary for killing bacteria and the like.
Insufficient elution of the antibacterial metal causes the antibacterial effect to be insufficient, there is no risk that the antibacterial metal elutes in large quantities at a time, causing safety problems, and the antibacterial action is reduced in a short period of time, Excellent antibacterial and antifungal effects are exhibited over a long period of time. Further, the antibacterial and antifungal agent of the present invention has excellent weather resistance and heat resistance, and is less likely to be discolored by heat or light when kneaded into a resin or the like.
When used as an antifungal agent, there is an effect that the commercial value of the resin product or the paint is enhanced without the color of the resin product or the paint being discolored.

Continued on the front page (72) Inventor Kazuo Hosoda 4-66-1, Horikiri, Katsushika-ku, Tokyo Miyoshi Oil & Fat Co., Ltd. (72) Inventor Masafumi Moriya 4-66-1, Horikiri, Katsushika-ku, Tokyo Miyoshi Oil & Fat Co., Ltd.

Claims (5)

[Claims] 1. An antibacterial and antifungal agent, wherein a reduction treatment is performed while an antibacterial metal is supported on an inorganic carrier. 2. The antibacterial and antifungal agent according to claim 1, wherein a silane coupling agent and / or a silane coupling agent combined with an organic substance are further bound to the inorganic carrier. 3. A method for producing an antibacterial / antifungal agent, comprising bringing a solution containing an antibacterial metal ion into contact with an inorganic carrier and reducing the solution. 4. The method for producing an antibacterial / antifungal agent according to claim 3, wherein a silane coupling agent and / or a silane coupling agent combined with an organic substance are bound to the inorganic carrier. 5. The antibacterial / antifungal agent according to claim 3, wherein a silane coupling agent and / or a silane coupling agent combined with an organic substance is bonded to the inorganic carrier before or after the reduction. Production method.