JPH11228423A - Lavaging composition for intestinal tract - Google Patents
Lavaging composition for intestinal tractInfo
- Publication number
- JPH11228423A JPH11228423A JP5282298A JP5282298A JPH11228423A JP H11228423 A JPH11228423 A JP H11228423A JP 5282298 A JP5282298 A JP 5282298A JP 5282298 A JP5282298 A JP 5282298A JP H11228423 A JPH11228423 A JP H11228423A
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- Prior art keywords
- composition
- flavors
- sodium
- flavor
- solution
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【0001】本発明は、服用し易い腸管洗浄液を調製す
るための組成物に関する。[0001] The present invention relates to a composition for preparing an intestinal lavage fluid which is easy to take.
【0002】[0002]
【従来の技術】近年、食生活の変化に伴い、消化器癌、
とりわけ大腸癌が増加の傾向にあり、癌の早期発見、早
期治療の観点から、大腸内視鏡検査および大腸手術の重
要性が益々増大している。これらの検査や手術には事前
に腸管内を完全に洗浄する必要があり、臨床の現場で
は、デイビスらの提案(G. R. Davis et al., Gastroen
terology, 78, 991(1980))に基づく次の処方(水溶液1
リットル中に含まれる溶質量)の洗浄液が、その効果と
安全性の高さゆえ、繁用されている。 ポリエチレングリコール4000 59.0 g 塩化ナトリウム 1.47 g 塩化カリウム 0.743g 無水硫酸ナトリウム 5.69 g 炭酸水素ナトリウム 1.69 g2. Description of the Related Art In recent years, gastrointestinal cancer,
In particular, colorectal cancer tends to increase, and the importance of colonoscopy and colorectal surgery is increasing from the viewpoint of early detection and early treatment of cancer. The intestinal tract must be thoroughly cleaned before performing these tests and operations, and in clinical practice, Davis et al. (GR Davis et al., Gastroen
terology, 78, 991 (1980))
(Soluble mass contained in liter) is widely used because of its high effect and safety. Polyethylene glycol 4000 59.0 g Sodium chloride 1.47 g Potassium chloride 0.743 g Anhydrous sodium sulfate 5.69 g Sodium bicarbonate 1.69 g
【0003】[0003]
【発明が解決しようとする課題】前記洗浄液は、通常、
2〜3リットルという大量を服用する必要があるが、塩
辛い、油臭い、ぬめり感があるなど服用しにくいため、
患者は相当の苦痛を我慢しながら長時間かけて所定量を
飲んでいるというのが現状である。そこで、服用し易い
腸管洗浄液の開発が、患者のみならず、医師、看護婦、
薬剤師からも強く要望されている。The cleaning liquid is usually
It is necessary to take a large amount of 2-3 liters, but it is difficult to take salty, oily, slimy,
At present, patients take a prescribed amount over a long period of time while putting up considerable pain. Therefore, the development of an intestinal lavage solution that is easy to take is not only for patients, but also for doctors, nurses,
There is a strong demand from pharmacists.
【0004】[0004]
【課題を解決するための手段】本発明者らは、前記処方
の腸管洗浄効果と安全性を損なうことなく、すなわち、
その処方を大幅に変えることなく、微量または少量の香
料ないし甘味料を添加することによって前記課題を解決
できないかと考え、先ず前記処方に種々の香料、甘味
料、呈味料を添加してそれぞれ飲み易さを調べた。その
結果、柑橘類の精油(香料)が好ましく、その1種の香
料よりも少なくとも2種の香料を使用した方がより好ま
しい傾向があること、中でもグレープフルーツ香料とオ
レンジ香料の組み合わせが顕著な効果を奏すること、さ
らには微量の甘味料を添加することにより一層飲み易く
なることを見出した。この知見を基にさらに検討を加え
本発明を完成するに至った。すなわち、本発明は、
(1)下記成分が下記の相対的重量範囲で配合され、こ
れに少なくとも2種の柑橘類の香料が添加されてなる腸
管洗浄液用組成物、 ポリエチレングリコール4000 55.0 〜63.0 g 塩化ナトリウム 1.3 〜 1.6 g 塩化カリウム 0.67〜 0.82g 硫酸ナトリウム 5.1 〜 6.3 g 炭酸水素ナトリウム 1.5 〜 1.9 g (2)2種の柑橘類の香料が、グレープフルーツ香料と
オレンジ香料である前記(1)に記載の腸管洗浄液用組
成物、(3)さらに少なくとも1種の甘味料が添加され
てなる前記(1)に記載の腸管洗浄液用組成物、(4)
甘味料がサッカリンのナトリウム塩である前記(3)に
記載の腸管洗浄液用組成物、および(5)下記の香料と
甘味料が下記の相対的重量範囲で添加されてなる前記
(4)に記載の腸管洗浄液用組成物、 グレープフルーツ香料 1〜20mg オレンジ香料 1〜20mg サッカリンのナトリウム塩 7〜50mg である。Means for Solving the Problems The present inventors did not impair the intestinal cleansing effect and safety of the above-mentioned formulation, namely,
Without drastically changing the prescription, it is thought that the problem can be solved by adding a small amount or a small amount of a flavor or a sweetener.First, various flavors, sweeteners, and flavors are added to the prescription, and each of them is drunk. I checked for ease. As a result, citrus essential oils (flavors) are preferred, and there is a tendency that it is more preferable to use at least two flavors than one flavor, and in particular, a combination of a grapefruit flavor and an orange flavor has a remarkable effect. It was further found that the addition of a small amount of a sweetener made it easier to drink. Further studies have been made based on this finding, and the present invention has been completed. That is, the present invention
(1) The following components are blended in the following relative weight ranges, and at least two citrus fragrances are added to the composition for intestinal lavage, polyethylene glycol 4000 55.0 to 63.0 g sodium chloride 1.3 to 1.6 g chloride Potassium 0.67 to 0.82 g Sodium sulfate 5.1 to 6.3 g Sodium bicarbonate 1.5 to 1.9 g (2) The composition for intestinal cleansing liquid according to (1), wherein the two citrus flavors are a grapefruit flavor and an orange flavor. 3) The composition for intestinal lavage according to the above item (1), further comprising at least one sweetener. (4)
The composition for intestinal lavage fluid according to the above (3), wherein the sweetener is a sodium salt of saccharin, and (5) the composition according to the above (4), wherein the following flavors and sweeteners are added in the following relative weight ranges. 1 to 20 mg of grapefruit flavor, 1 to 20 mg of orange flavor, and 7 to 50 mg of sodium salt of saccharin.
【0005】[0005]
【発明の実施の形態】本発明の主成分であるポエチレン
グリコール4000、塩化ナトリウム、塩化カリウム、
硫酸ナトリウムおよび炭酸水素ナトリウムの調合に特に
困難はなく、各成分の所定量を常法に従って混合すれば
よい。本発明で使用する柑橘類の香料としては、例えば
圧搾法、水蒸気蒸留法等によって得られる精油のみなら
ず、合成香料単独、あるいはその他の芳香化合物や添加
物を含有するグレープフルーツ、ぶんたん、夏みかん、
八朔などのザボン類、みかん、オレンジ、ネーブルなど
の普通オレンジ類、レモン、ライム、ユズ、カボス、ス
ダチなどの香酸柑橘類などの所謂柑橘類様の香料を意味
し、なかでもグレープフルーツ香料とオレンジ香料の組
み合わせが好ましい。ポリエチレングリコール4000
と電解質からなる腸管洗浄液用組成物(1リットル用)
へのそれら香料の添加量は、精油又は合成香料の正味計
算で1〜20mg程度が好ましい。また、本発明で使用
する甘味料は天然甘味料、合成甘味料のいずれでもよい
が、サッカリンのナトリウム塩、ステビア、アスパルテ
ーム、ソーマチンなどの微量で強力な甘味を発揮するも
のが好ましいく、その中でもサッカリンのナトリウム塩
が特に好ましい。甘味料の1リットル用組成物当たりの
添加量は、前記主成分に基づく塩味とマッチして飲みや
すい甘味が出る量、例えばサッカリンのナトリウム塩の
場合で7〜50mg程度が好ましい。DESCRIPTION OF THE PREFERRED EMBODIMENTS Polyethylene glycol 4000, which is a main component of the present invention, sodium chloride, potassium chloride,
There is no particular difficulty in preparing sodium sulfate and sodium hydrogencarbonate, and a predetermined amount of each component may be mixed according to a conventional method. Examples of the citrus flavors used in the present invention include not only essential oils obtained by squeezing, steam distillation, etc., but also grapefruits containing synthetic flavors alone or other aromatic compounds and additives, buntan, summer tangerines,
Pomelo such as Hassaku, oranges such as oranges, oranges and navels, and so-called citrus-like flavors such as lemon, lime, yuzu, kabos, and perfume citrus such as Sudachi, among which grapefruit and orange flavors Combinations are preferred. Polyethylene glycol 4000
Composition for intestinal lavage, consisting of water and electrolyte (for 1 liter)
The amount of these flavors added to the essential oil or synthetic flavor is preferably about 1 to 20 mg by net calculation. Further, the sweetener used in the present invention may be any of natural sweeteners and synthetic sweeteners, but those which exert a trace amount of strong sweetness such as sodium salt of saccharin, stevia, aspartame, thaumatin, and the like, among which, The sodium salt of saccharin is particularly preferred. The amount of the sweetener added per liter of the composition is preferably an amount that gives a sweet taste that is easy to drink in accordance with the salty taste based on the main component, for example, about 7 to 50 mg in the case of saccharin sodium salt.
【0006】本発明の組成物は、各成分を混合した固体
状、特に粉末状のもの、またこれに適量の水を加えて調
製した濃縮液、さらには、そのまま服用することができ
る濃度にまで水を加えて調製した洗浄液の形のいずれで
あってもよいが、保存、運搬などの点から用時水を加え
て洗浄液を調製することができる粉末状のものが好まし
い。本発明の組成物は粉末製剤調製のために必要な賦形
剤、たとえばデキストリンや乳糖など、さらには水溶液
とする場合の可溶化剤、たとえばシクロデキストリンな
どの適量が適宜配合されたものでもよい。[0006] The composition of the present invention is a solid, especially a powder, in which the respective components are mixed, a concentrated liquid prepared by adding an appropriate amount of water to the solid, and a concentration which can be taken as it is. The cleaning liquid may be in any form prepared by adding water, but a powdery liquid which can be prepared by adding water at the time of use from the viewpoint of storage and transportation is preferred. The composition of the present invention may be appropriately blended with excipients necessary for the preparation of a powder preparation, for example, dextrin and lactose, and further, a solubilizer for preparing an aqueous solution, for example, an appropriate amount of cyclodextrin.
【0007】[0007]
【実施例】以下に実施例および試験例により本発明を説
明するが、これによって本発明の範囲が限定されるもの
ではない。 実施例1 2リットルの腸管洗浄液調製用として、下記成分を下記
分量でアルミ袋に充填し、密封した。 ポリエチレンゴリコール4000 118.0 g 塩化ナトリウム 2.93 g 塩化カリウム 1.49 g 無水硫酸ナトリウム 11.4 g 炭酸水素ナトリウム 3.37 g α−シクロデキストリン 5.0mg デキストリン 55.0mg 乳糖 30.0mg グレープフルーツ香料(精油) 6.0mg オレンジ香料(精油) 3.0mg サッカリンのナトリウム塩 20.0mgThe present invention will be described below with reference to examples and test examples, but the scope of the present invention is not limited by these examples. Example 1 An aluminum bag was filled with the following components in the following amounts for the preparation of a 2 liter intestinal lavage solution and sealed. Polyethylene Golicol 4000 118.0 g Sodium chloride 2.93 g Potassium chloride 1.49 g Anhydrous sodium sulfate 11.4 g Sodium bicarbonate 3.37 g α-Cyclodextrin 5.0 mg Dextrin 55.0 mg Lactose 30.0 mg Grapefruit flavor (essential oil) 6.0 mg Orange flavor (essential oil) 3.0 mg Saccharin sodium salt 20.0mg
【0008】実施例2 2リットルの腸管洗浄液調製用として、下記成分を下記
分量でアルミ袋に充填し、密封した。 ポリエチレングリコール4000 118.0 g 塩化ナトリウム 2.93g 塩化カリウム 1.49g 無水硫酸ナトリウム 11.4 g 炭酸水素ナトリウム 3.37g α−シクロデキストリン 5.0 g デキストリン 55.0 g 乳糖 30.0 g グレープフルーツ香料(精油) 5.0 g オレンジ香料(精油) 5.0 gExample 2 For preparing 2 liters of intestinal lavage fluid, the following components were filled in the following amounts into aluminum bags and sealed. Polyethylene glycol 4000 118.0 g Sodium chloride 2.93 g Potassium chloride 1.49 g Anhydrous sodium sulfate 11.4 g Sodium bicarbonate 3.37 g α-cyclodextrin 5.0 g Dextrin 55.0 g Lactose 30.0 g Grapefruit flavor (essential oil) 5.0 g Orange flavor (essential oil) 5.0 g
【0009】試験例1 被験液の調製 1)実施例1液および実施例2液 本発明の効果を官能試験により評価するため、実施例1
及び実施例2の組成物1袋づつを蒸留水に溶解して、そ
れぞれ2リットルの溶液(実施例1液及び実施例2液)
とした。 2)対照液 ポリエチレングリコール4000 118.0 g 塩化ナトリウム 2.93g 塩化カリウム 1.49g 無水硫酸ナトリウム 11.4 g 炭酸水素ナトリウム 3.37gTest Example 1 Preparation of test solution 1) Example 1 solution and Example 2 solution In order to evaluate the effect of the present invention by a sensory test, Example 1 was used.
Then, each bag of the composition of Example 2 was dissolved in distilled water, and 2 liters of each solution (Example 1 solution and Example 2 solution)
And 2) Control solution Polyethylene glycol 4000 118.0 g Sodium chloride 2.93 g Potassium chloride 1.49 g Anhydrous sodium sulfate 11.4 g Sodium bicarbonate 3.37 g
【0010】3)比較例1〜14 実施例2の組成物中、グレープフルーツ香料(精油)と
オレンジ香料(精油)を配合していない組成物に、下記
〔表1〕に記載の香料(精油:以下、香料とのみ記載)
を添加し、それぞれ前記と同様にして2リットルの水溶
液を調製して、比較例1〜14とした。3) Comparative Examples 1 to 14 In the composition of Example 2, a composition containing no grapefruit flavor (essential oil) and orange flavor (essential oil) was added to a flavor (essential oil: Below, only described as perfume)
Was added, and 2 liters of an aqueous solution was prepared in the same manner as described above, to thereby obtain Comparative Examples 1 to 14.
【0011】[0011]
【表1】 [Table 1]
【0012】官能試験 比較液1〜14、実施例1液及び実施例2液の計16種
の被験液を、4種ずつの4組に分け、それぞれの組に対
して対照液を加えた5検液を1被験液として官能試験に
供した。官能試験は、第1日目に被験液群1組につい
て、定刻(午前10時)に、23人のパネラー(年齢2
2才〜67才の健常な男子16人、女子7人)が被験液
を50mlずつ飲用し、各被験液毎に次の評価基準に答
えるアンケート形式で行われた。 A:非常に飲み易い。 b:飲みやすい。 C:まあまあ飲める。 D:飲み難い。 E:非常に飲み難い。 つづく第2〜第4日で、同一パネラーによる同一評価方
法で他の3つの被験液群の官能テストを1日群ずつ実施
し、その集計結果を〔表2〕示した。Sensory Test A total of 16 kinds of test liquids, Comparative Liquids 1 to 14, Liquids of Example 1 and Liquids of Example 2, were divided into 4 sets of 4 types, and a control liquid was added to each set. The test solution was subjected to a sensory test as one test solution. On the first day, a sensory test was conducted for one set of test liquid groups at the scheduled time (10:00 am) with 23 panelists (age 2).
16 healthy boys and 7 girls aged 2 to 67 years old) drank 50 ml of the test solution, and a questionnaire format was given for each test solution, answering the following evaluation criteria. A: Very easy to drink. b: Easy to drink. C: OK. D: Difficult to drink. E: Very difficult to drink. On the following second to fourth days, sensory tests of the other three test liquid groups were carried out one day at a time by the same evaluation method using the same panelists, and the total results are shown in [Table 2].
【0013】[0013]
【表2】 集計結果〔表2〕から、実施例1液及び実施例2液は、
対照液に対して飲み難さの改善が明らかに認められた。[Table 2] From the tabulation results [Table 2], Example 1 solution and Example 2 solution
An improvement in dysphagia was clearly observed relative to the control solution.
【0014】[0014]
【発明の効果】本発明によれば、従来の腸管洗浄液の問
題点とされている服用のし難さが顕著に改善され、大量
の服用を容易にする腸管洗浄液が提供できる。According to the present invention, it is possible to provide an intestinal lavage solution which can remarkably improve the difficulty of taking the intestinal lavage solution, which is a problem of the conventional intestinal lavage solution, and which facilitates taking large quantities.
Claims (5)
れ、これに少なくとも2種の柑橘類の香料が添加されて
なる腸管洗浄液用組成物。 ポリエチレングリコール4000 55.0 〜63.0 g 塩化ナトリウム 1.3 〜 1.6 g 塩化カリウム 0.67〜 0.82g 硫酸ナトリウム 5.1 〜 6.3 g 炭酸水素ナトリウム 1.5 〜 1.9 gAn intestinal cleansing composition comprising the following components in the following relative weight ranges, and at least two citrus fragrances added thereto. Polyethylene glycol 4000 55.0 to 63.0 g Sodium chloride 1.3 to 1.6 g Potassium chloride 0.67 to 0.82 g Sodium sulfate 5.1 to 6.3 g Sodium bicarbonate 1.5 to 1.9 g
香料とオレンジ香料である請求項1に記載の腸管洗浄液
用組成物。2. The intestinal lavage composition according to claim 1, wherein the two citrus flavors are a grapefruit flavor and an orange flavor.
てなる請求項1に記載の腸管洗浄液用組成物。3. The composition for intestinal lavage according to claim 1, further comprising at least one sweetener.
請求項3に記載の腸管洗浄液用組成物。4. The composition for intestinal lavage according to claim 3, wherein the sweetener is a sodium salt of saccharin.
囲で添加されてなる請求項4に記載の腸管洗浄液用組成
物。 グレープフルーツ香料 1〜20mg オレンジ香料 1〜20mg サッカリンのナトリウム塩 7〜50mg5. The composition for intestinal lavage according to claim 4, wherein the following flavors and sweeteners are added in the following relative weight ranges. Grapefruit flavor 1-20mg Orange flavor 1-20mg Saccharin sodium salt 7-50mg
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5282298A JPH11228423A (en) | 1998-02-17 | 1998-02-17 | Lavaging composition for intestinal tract |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5282298A JPH11228423A (en) | 1998-02-17 | 1998-02-17 | Lavaging composition for intestinal tract |
Publications (1)
Publication Number | Publication Date |
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JPH11228423A true JPH11228423A (en) | 1999-08-24 |
Family
ID=12925554
Family Applications (1)
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---|---|---|---|
JP5282298A Pending JPH11228423A (en) | 1998-02-17 | 1998-02-17 | Lavaging composition for intestinal tract |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003073260A (en) * | 2001-08-30 | 2003-03-12 | Nihon Pharmaceutical Co Ltd | Composition for oral enterolavage liquid and packed preparation for the oral enterolavage liquid |
JP2005187448A (en) * | 2004-04-02 | 2005-07-14 | Ajinomoto Co Inc | Composition for cleaning intestinal tract |
JP2007511610A (en) * | 2003-11-17 | 2007-05-10 | ブレーントリー ラボラトリーズ インコーポレーティッド | PEG solution concentrate for treatment |
US7658914B2 (en) | 2002-10-25 | 2010-02-09 | Norgine Bv | Colon cleansing compositions |
WO2013086382A1 (en) | 2011-12-07 | 2013-06-13 | Msm Innovations, Inc. | Method for bowel preparation |
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US9585937B2 (en) | 2011-12-07 | 2017-03-07 | Msm Innovations, Inc. | Method and kit for bowel preparation |
US9592252B2 (en) | 2011-03-11 | 2017-03-14 | Norgine Bv | Colonoscopy—preparation |
-
1998
- 1998-02-17 JP JP5282298A patent/JPH11228423A/en active Pending
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003073260A (en) * | 2001-08-30 | 2003-03-12 | Nihon Pharmaceutical Co Ltd | Composition for oral enterolavage liquid and packed preparation for the oral enterolavage liquid |
US7658914B2 (en) | 2002-10-25 | 2010-02-09 | Norgine Bv | Colon cleansing compositions |
JP2007511610A (en) * | 2003-11-17 | 2007-05-10 | ブレーントリー ラボラトリーズ インコーポレーティッド | PEG solution concentrate for treatment |
JP2005187448A (en) * | 2004-04-02 | 2005-07-14 | Ajinomoto Co Inc | Composition for cleaning intestinal tract |
WO2005097144A1 (en) * | 2004-04-02 | 2005-10-20 | Ajinomoto Co., Inc. | Composition for cleaning intestinal canal |
US11529368B2 (en) | 2011-03-11 | 2022-12-20 | Norgine Bv | Colonoscopy—preparation |
US10792306B2 (en) | 2011-03-11 | 2020-10-06 | Norgine Bv | Colonoscopy—preparation |
US10780112B2 (en) | 2011-03-11 | 2020-09-22 | Norgine Bv | Colonoscopy-preparation |
US10646512B2 (en) | 2011-03-11 | 2020-05-12 | Norgine Bv | Colonoscopy - preparation |
US9592252B2 (en) | 2011-03-11 | 2017-03-14 | Norgine Bv | Colonoscopy—preparation |
US9585937B2 (en) | 2011-12-07 | 2017-03-07 | Msm Innovations, Inc. | Method and kit for bowel preparation |
US9629917B2 (en) | 2011-12-07 | 2017-04-25 | Msm Innovations, Inc. | Method for bowel preparation |
JP2018100273A (en) * | 2011-12-07 | 2018-06-28 | エムエスエム イノベーションズ、インク. | Method for gastrointestinal tract pretreatment |
EP2787982A4 (en) * | 2011-12-07 | 2015-05-06 | Msm Innovations Inc | Method for bowel preparation |
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