JPH11226099A - Deodorant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a deodorant which is capable of effectively removing or decreasing the malodors and offensive odors formed in the metabolism within the human and animal bodies and in toilets, stock raising ranches and other environments. SOLUTION: The hydrophilic solvent extract (or its hydrolyzate) of Bear-berry (Arctostaphylos uva-ursi (L.) Sprengel) is used as the effective component of the deodorant. The hydrophilic solvent extract is prepd. by drying the leaves of the Bear-berry at need and extracting the pulverized leaves by a hydrophilic solvent. The hydrophilic solvent used for the extraction includes water, methanol, ethanol, isopropyl alcohol, acetone or their solvent mixture, etc., for which the water or the ethanol and/or water/ ethanol solvent mixture is more preferable as this solvent is not of a problem in case of remaining in order for use particularly for medical purposes or as food. Org. acid or sugar content may be previously added to the solvent. In such a case, the extraction of the component is more effectively executed. Citric acid, malic acid, acetic acid and ascorbic acid are preferable as the org. acid. The amt. of the addition thereof is adequately 0.05 to 2 wt.% of the weight of the solvent and is preferably so adjusted as to be kept within a range of pH3.0 to 5.0. Fructose, glucose, sucrose, maltose, etc., are usable as the sugar.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a deodorant. More specifically, the present invention relates to metabolism in the body of humans and animals, indoors, cars, refrigerators, toilets, livestock ranches, pig farms, poultry farms, fish farms, and other odors that are generated in other environments. The present invention relates to a deodorant capable of effectively removing or reducing malodors and off-flavors derived from components having the same, for example, amines, mercaptans, and fatty acids.

[0002]

2. Description of the Related Art As a deodorant capable of effectively removing or reducing malodors and unpleasant odors generated in metabolism in humans and animals, toilets, livestock ranches and other environments, mushrooms include water or water. There are those which use a component extracted with a neutral solvent as an active ingredient (JP-A-2-277456,
U.S. patent application Ser. No. 08/107333, European patent 038055).

[0003]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a method for effectively eliminating or reducing bad odors and odors generated in metabolism in humans and animals, toilets, livestock ranches and other environments. It is to provide an odorant.

[0004]

DISCLOSURE OF THE INVENTION The present invention provides a deodorant containing a hydrophilic solvent extract of Prunus vulgaris as an active ingredient. The present invention also provides a deodorant containing, as an active ingredient, a hydrolyzate of a hydrophilic solvent extract of Prunus vulgaris. The deodorant of the present invention can be used in the form of foods, oral compositions, pharmaceuticals, feeds, etc., or in the form of aerosol compositions.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The deodorant of the present invention comprises a hydrophilic solvent extract of awaluushi, a hydrolyzate of hydrophilic solvent extract of awaulushi, or a mixture thereof as an active ingredient. Metabolism in animals and in the body of animals, toilets, livestock ranches and other environments, can effectively remove or reduce odors and odors. Uwaurushi, also known as Bearberry, is native to mountainous regions in central Honshu, Japan, and cold regions and alpine mountains such as Hokkaido, Europe, Asia, the northern United States, and Canada. The hydrophilic solvent extract of the leaves has a slight dead leaf-like aroma and slight bitterness, presents a light brown to dark green brown color, contains arbutin, hydroquinone, tannins, gallic acid, etc., and is an aqueous extract. Has been reported to have antibacterial, antiviral, diuretic, and the like.

[0006] The hydrophilic solvent extract of eucalyptus used for the deodorant of the present invention is obtained by drying crushed awaulushi leaves and crushing the leaves with a hydrophilic solvent if necessary. Hydrophilic solvents used for extraction include water, methanol, ethanol, isopropyl alcohol, acetone,
Alternatively, a mixed solvent thereof and the like can be mentioned. In particular, water or ethanol or a mixed solvent of water / ethanol, which does not cause a problem even if it remains, is preferably used for medical or edible use. A mixed solvent with water is more preferable than extraction with an alcohol or acetone solvent alone. Extraction solvent is material 1
In general, it may be added 2 to 20 times (weight ratio). In the case of water, the extraction temperature and time are 60 to 100 ° C. for 5 minutes to 5 minutes.
A suitable time is preferably 30 minutes to 3 hours at 70-90 ° C, most preferably 30 minutes at 80 ° C.

[0007] Further, an organic acid or a sugar can be added to the solvent, and in this case, the components can be more effectively extracted. As the organic acid, citric acid, malic acid, acetic acid, and ascorbic acid are preferable. The amount added is
0.05 to 2% by weight is appropriate, and the pH is preferably adjusted to a range of 3.0 to 5.0. As sugar, fructose, glucose, sucrose, maltose and the like can be used. An appropriate amount of addition is 0.5 to 5% by weight. In this case, the effective component in the cell wall of the leaf can be more efficiently extracted by the osmotic pressure. Further, about 0.01 to 0.1% by weight of cellulase or amylase is added to water, and 25 ° C.
The reaction may be performed at 40 ° C. for 2 to 24 hours to decompose the cell wall or protein before extracting. Furthermore, once the leaves of the mulberry are frozen and thawed, the tissue (cell wall) is destroyed and the active ingredient can be efficiently extracted.
The extract obtained by further hydrolyzing the hydrophilic solvent extract of awaulushi with a hydrolase such as β-glucosidase, a mineral acid such as hydrochloric acid or sulfuric acid, or a strongly acidic organic acid (eg, malic acid or citric acid), It is preferable as an active ingredient of the deodorant of the present invention. Such a hydrolyzate can be obtained, for example, by adding β-glucosidase to a hydrophilic solvent extract of Pleurotus radishes from 0.01 to 0.01%.
It can be easily produced by adding 1% by weight and treating at 30 to 50 ° C. for 1 to 48 hours.

[0008] As described above, it has been reported that the hydrophilic solvent extract of Prunus vulgaris has an antibacterial action, an antiviral action, a diuretic action and the like, but it is not known that it has any deodorizing effect. The deodorant of the present invention may be composed of 100% by weight of a hydrophilic solvent extract (or a hydrolyzate thereof) of A. The deodorant of the present invention can be used in the form of foods, oral compositions, pharmaceuticals, feeds, etc., or in the form of aerosol compositions. Foods containing the deodorant of the present invention is not particularly limited, for example, lollies hydrophilic solvent extract candy, chewing gum, confectionery, bread, pickles, seasonings, miso, porridge, drinks, jelly, soup, Gyoza, health food, wine, shochu and the like. The content of the hydrophilic solvent extract of awaulushi (dry weight basis) (or its hydrolyzate) in food is
Daily intake 0.01-50 mg, especially 0.1-5
The concentration should be appropriate for taking mg.
0.000005 to 50% by weight, preferably 0.000
5 to 0.5% by weight, more preferably 0.005 to 0.5% by weight.
05% by weight.

The oral composition containing the deodorant of the present invention is not particularly limited, but examples thereof include toothpaste and mouthwash compositions. The content of the hydrophilic solvent extract of awaurushi (on a dry weight basis) (or a hydrolyzate thereof) in the oral composition is as follows:
Usually, 0.000005 to 50% by weight, preferably 0.0005 to 0.5% by weight, more preferably 0.0 to 0.5% by weight.
Between 0.5 and 0.05% by weight. The drug containing the deodorant of the present invention is not particularly limited, but examples include gastrointestinal drugs, vitamins and the like. Hydrophilic solvent extract of eucalyptus in pharmaceutical products (dry basis) (or hydrolyzate thereof)
Is usually 0.000005 to 50% by weight,
Preferably it is 0.0005 to 0.5% by weight, more preferably 0.005 to 0.05% by weight.

[0010] The feed containing the deodorant of the present invention is not particularly limited either. For example, livestock such as cattle, pigs, horses and sheep,
Poultry such as chicken, quail, goose, turkey, duck, ostrich, etc.
Feeds of pet animals such as dogs, cats and small birds, animals (including fishes and the like) bred in zoos, aquariums, fish farms and the like, and other animal feeds. The content of the hydrophilic solvent extract of awaluushi (on a dry weight basis) (or hydrolyzate thereof) in such feed is usually 0.000005 to 50% by weight, preferably 0.0005 to 0.5% by weight. %, More preferably 0.005 to 0.05% by weight. The content of the hydrophilic solvent extract (on a dry weight basis) of the mulberry in the aerosol composition (or a hydrolyzate thereof) is usually 0.1%.
000005-5% by weight, preferably 0.0005-5%
0.5% by weight, more preferably 0.005 to 0.05
% By weight.

The oral deodorant of the present invention can remove or reduce bad odors and off-flavors (bad breath and body odor) generated by orally taking a proper amount of food or food. Oral ingestion of the deodorant of the present invention is usually carried out before ingestion of food.
At the time of ingestion, it may be after the ingestion, but preferably before or at the time of ingestion of the food. The oral intake depends on the degree of bad breath and body odor, and is not particularly limited.
(Or its hydrolyzate) as 0.0
The dose is 1 to 50 mg, preferably 0.1 to 5 mg. In order to use the deodorant of the present invention for removing or reducing malodors and off-flavors in the environment, it is preferable to add the deodorant of the present invention to feed of a target animal.

In addition, an environment (for example, indoors, in a car, a refrigerator, a toilet, or the like) in which components having a bad odor or a bad odor (eg, amines, mercaptans, fatty acids, etc.) may be generated.
It is also effective to spray the deodorant of the present invention on livestock farms, pig farms, poultry farms, fish farms, etc.). The amount of application varies depending on the degree of offensive odor / odor, but usually 1 m ²
Or 0.0005 as a hydrophilic solvent extract (dry weight basis) (or a hydrolyzate thereof) of euphorbia per 1 m ³
10 to 10 g, preferably about 0.005 to 1 g is appropriate. As described above, the deodorant active ingredient of the present invention is a hydrophilic solvent extract (a dry weight basis) of Pleurotus terrestris (or a hydrolyzate thereof), whereby a deodorant effect is obtained.

[0013]

Next, the present invention will be described by way of examples. Production Example 1 15 kg of hot water was added to 1 kg of dried leaves of eucalyptus, and extracted at 80 ° C. for 180 minutes. 7.58 kg of extract
Was concentrated to obtain 0.5 kg of a concentrated liquid. Production Example 2 15 kg of a 0.3% by weight aqueous solution of malic acid was added to 1 kg of dried leaves of a mulberry, and extracted at 90 ° C. for 60 minutes.
10.9 kg of the extract was concentrated to obtain 0.5 kg of a concentrate. Production Example 3 15 kg of water was added to 1 kg of dried leaves of eucalyptus, and 8
Extracted at 0 ° C. for 90 minutes. The extract was adjusted to 15 kg by adding water to 9.7 kg. To 150 g of this extract, 1 β-glucosidase (manufactured by Oriental Yeast Co., Ltd., 2000 U) was added.
After adding 00 mg, the mixture was reacted at 37 ° C. for 22 hours.

Test Example 1 A liquid (stock solution) obtained by diluting the extract of Production Example 1 200-fold with purified water, the pH of which was adjusted to 7.25 with 1N NaOH (adjusted liquid), and the extract was further concentrated at a predetermined concentration. The deodorizing effect on methyl mercaptan was measured using the following test method. [Test Method] 8 ml of the test solution was placed in a 155 ml vial. As a control, 8 ml of purified water was added. The vial is capped with a silicon stopper, sealed with an aluminum cap, and a methyl mercaptan standard solution (content: 1 μg / μl, benzene solution) manufactured by Wako Pure Chemical Industries, Ltd., with an initial concentration of methyl mercaptan of 8.4 ppm. Was added as follows. After stirring with a touch mixer for 20 seconds, 1 ml of air was injected with a gas tight syringe, 1 ml of the headspace was removed after pour-out, and subjected to gas chromatography. The peak area of methyl mercaptan in the gas chromatogram was measured to determine the methyl mercaptan concentration (ppm). Table 1 shows the results immediately after stirring, and after 15 minutes, 30 minutes and 60 minutes.

[0015]

[Table 1] Table 1 (Methyl mercaptan concentration (ppm)) Sample immediately after 15 minutes After 30 minutes After 60 minutes Stock solution (pH = 4.39) 6.72 5.12 4.18 2.92 Adjustment solution (pH = 7.25) 3.90 0.22 0 0 Adjustment solution x 1/2 4.74 0.88 0.13 0 Adjustment solution x 1/4 5.46 2.19 0.63 0 Adjustment solution x 1/10 6.18 4.64 3.20 1.13 Adjustment solution x 1/20 6.21 5.56 5.09 4.39 As is clear from the above deodorization power test results, It can be seen that the adjustment liquid has an excellent deodorizing effect up to a 1/10 dilution.

Test Example 2 A liquid (stock solution) obtained by diluting the extract of Production Example 2 by 200 times with purified water, the pH of which was adjusted to 7.25 with 1N NaOH (adjusted liquid), and the extract was further concentrated at a predetermined concentration. The methylmercaptan concentration (ppm) was determined in the same manner as in Test Example 1 except that methylmercaptan was added so that the initial concentration was 8.4 ppm. Table 2 shows the results immediately after stirring, after 15 minutes, 30 minutes, and 60 minutes.

[0017]

[Table 2] Table 2 (Methyl mercaptan concentration (ppm)) Sample immediately after 15 minutes 30 minutes After 60 minutes Stock solution (pH = 3.01) 6.50 6.18 6.02 5.73 Adjustment solution (pH = 7.25) 3.44 0.170 0 0 Adjustment solution x 1/2 4.65 0.69 0.05 0 Adjustment solution x 1/4 5.42 1.98 0.50 0 Adjustment solution x 1/10 6.09 4.62 3.12 0.87 Adjustment solution x 1/20 6.15 5.34 4.66 3.10 As is clear from the above deodorization power test results, It can be seen that the adjustment liquid has an excellent deodorizing effect up to a 1/10 dilution.

Test Example 3 The solution before the β-glucosidase treatment in Production Example 3 was purified water with 6.
Solution (stock solution A) diluted 67 times, pH of stock solution A was adjusted to 1N
A solution adjusted to 7.25 with aOH (adjusted solution A), further diluted to a predetermined concentration, a solution obtained by diluting a β-glucosidase-treated solution to 6.67 times with purified water (stock solution B), p of stock solution B
The deodorizing effect on methyl mercaptan was examined in the same manner as in Test Example 1 using a solution prepared by adjusting H to 7.25 with 1N NaOH (preparation solution B) and further diluting the solution to a predetermined concentration. Table 3 shows the results immediately after stirring, and after 15 minutes, 30 minutes and 60 minutes.

[0019]

[Table 3] Table 3 (Methyl mercaptan concentration (ppm)) Sample immediately after 15 minutes After 30 minutes After 60 minutes Stock solution A (pH = 4.65) 6.57 5.88 4.27 3.34 Adjustment solution A (pH = 7.25) 4.03 0.31 0 0 Adjustment Solution Ax 1/2 4.98 1.05 0.36 0 Adjustment solution Ax 1/4 5.22 2.21 0.80 0 Adjustment solution Ax 1/10 5.96 4.82 3.31 1.27 Adjustment solution Ax 1/20 6.40 5.76 5.32 4.72 Stock solution B (pH = 5.22) 3.21 0.24 0 0 Adjustment solution B (pH = 7.25) 0.50 0 0 0 Adjustment solution Bx 1/2 0.67 0 0 0 Adjustment solution Bx 1/4 1.13 0 0 0 Adjustment solution Bx 1/10 2.87 0.18 0 0 Adjustment solution Bx 1/20 3.46 0.29 0 0 Adjustment solution Bx 1/50 4.77 0.95 0.25 0 Adjustment solution Bx 1/100 6.16 4.35 3.24 2.68 As is clear from the above deodorizing power test results, the β-glucosidase-treated solution is compared with the solution before the treatment. It turns out that it has about 5 times the deodorizing power.

Example 1 A deodorant comprising the extract (concentrate) of Production Example 1.

Example 2 A deodorant consisting of a powder obtained by drying and pulverizing the extract (concentrate) of Production Example 1.

Example 3 A powder obtained by drying and pulverizing the extract (concentrate) of Production Example 1.
A deodorant in the form of a health food prepared by mixing 05 g, whey calcium 0.2 g, isomaltooligosaccharide 0.2 g, and cellulose 1.05 g, and blending the resulting mixture into granules.

Example 4 (Chewing gum) Using the extract obtained in Production Example 1, chewing gum was produced with the following composition. The numbers indicate the number of grams in 100 g of chewing gum. Palatinit 64.0 Gum base 25.0 70% Sorbitol 5.7 Glycerin 5.0 Extract of Preparation 1 0.3

Example 5 (candy) Using the extract obtained in Example 1, a candy was produced with the following composition. The number is g in 100g of candy
Indicates a number. Granulated sugar 60.0 Sugar alcohol 20.0 Acidity 0.5 Extract of Production Example 1 0.2 Fruit flavor Suitable amount Colored amount Suitable amount purified water 17.5

Example 6 (Drink) Using the extract obtained in Production Example 2, a drink was produced with the following composition. The numbers indicate the number of g in 100 g of the drink. Liquid sugar 10.7 Sugar 3.0 Malic acid 0.1 Fragrance 0.2 Extract of Production Example 2 0.03 Purified water 85.97

Example 7 (Aerosol composition) Using the extract obtained in Production Example 3, an aerosol composition was produced with the following composition. The figures are aerosol composition 100
Indicates the number of g in g. Ethanol 99.16 ethyl paraben 0.12 propyl paraben 0.06 butyl paraben 0.06 extract of Preparation 3 0.5

The deodorant of the present invention can be used in combination with a material that has a favorable effect on the intestinal environment, such as oligosaccharides, dietary fiber, and lactic acid bacteria.

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Claims (7)

[Claims] 1. A deodorant comprising a hydrophilic solvent extract of Pleurotus terrestris as an active ingredient. 2. A deodorant comprising, as an active ingredient, a hydrolyzate of a hydrophilic solvent extract of euphorbia. 3. The deodorant according to claim 1, which is in the form of a food. 4. The method according to claim 1, which is in the form of an oral composition.
The deodorant described. 5. The deodorant according to claim 1, which is in the form of a medicament. 6. The deodorant according to claim 1, which is in the form of a feed. 7. The method according to claim 1, which is in the form of an aerosol composition.
Or the deodorant according to 2.