JPH11209296A - Aloe tablet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare an aloe tablet having a high hardness and extremely readily ingestible, not being disintegrated even by transportation, by making the tablet include an aloe powder and lactulose as active ingredients therein. SOLUTION: This tablet is prepared by including (A) an aloe powder and (B) lactulose as active ingredients. The amounts of the ingredients based on 1 g tablet are preferably 50-800 mg ingredient A and >=0.1 pt.wt. (more preferably 0.2-10 pts.wt.) ingredient B based on 1 pt.wt. ingredient A. The ingredient B is preferably of >=95% purity. The tablet is has preferably 6-15 kg hardness in either of the horizontal and the vertical directions and is capable of withstanding handling, etc., at the time of tableting and packaging. Furthermore, the tablet is not only capable of improving the productivity and product quality but also is excellent in palatability such as no sticking to the interior of an oral cavity at the time of ingestion.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to aloe tablets having extremely high hardness and containing aloe powder and lactulose having various physiological effects as active ingredients and belonging to the genus Aloe powder, lactulose and bifidobacterium. Microorganisms, microorganisms belonging to the genus Lactobacillus,
One of microorganisms selected from the group consisting of microorganisms belonging to the genus Streptococcus, microorganisms belonging to the genus Pediococcus, and microorganisms belonging to the genus Ryuconostoc (hereinafter these microorganisms may be collectively referred to as lactic acid bacteria). The present invention relates to an aloe tablet containing a species or a mixture of two or more microorganism powders as an active ingredient and having extremely high hardness.

[0002] In this specification, the vertical direction is a direction in which pressure is applied and compressed by a punch during tableting, and the horizontal direction is a direction perpendicular to the vertical direction. The horizontal hardness of the tablet is
The hardness of the tablet in the vertical direction is measured by applying a static load in the vertical direction and crushing by applying a load in the vertical direction according to the conventional method. Displayed in units.

[0003]

2. Description of the Related Art Lactulose is a disaccharide consisting of galactose and fructose (4-O-β-D-galactopyranosy).
l-α-D-fructose), which is produced by subjecting lactose to a Roblie-Debruine rearrangement. Lactulose
Growth factors of bifidobacteria (Diagnosis and new drugs, Volume 10, Volume 5)
No. 75, 1973)
It is used in formula milk powder, milk powder for the weaning period and the like. Lactulose is also known to have an effect of reducing symptoms of hepatic encephalopathy and hepatic coma, and has already been used for treatment (Psychiatry, Vol. 15, No. 10, No. 1101).
Page, 1973).

However, lactulose is not known to be effective as an excipient for increasing tablet hardness. The present inventors have previously found that lactulose is effective as an excipient for increasing the hardness of tablets, and have already filed a patent application (Japanese Patent Application No. 9-13429).
Hereinafter referred to as the earlier application).

On the other hand, aloe is a perennial and succulent plant of the lily family, and has been widely used as a folk medicine in Japan since the Edo period for insect bites, burns and the like. Aloe has the following pharmacological effects: chronic gastritis, enteritis, loss of appetite due to weakness in the stomach, excellent effect on stomach leaning, effective treatment of constipation and hemorrhoids, skin injury by insects, burns, sunburn due to sea bathing, etc. It is known that it has excellent effects (Koichi Ohki, "Basic knowledge of foodstuffs for professionals", p. 718, Ota Publications, 1991).

As a method for producing aloe powder, a method is known in which fresh leaves are thoroughly washed, dried with sunlight, and the dried leaves are ground into a powder by mortaring. Encyclopedia of Modern Health Medicinal Foods, Specially-Equipped Desk Top Edition, p. 346, Sanseido Planning, 1984). Furthermore, as a method for producing aloe powder on an industrial scale, the outer skin of aloe vera leaves is removed, and the gel inside the leaves is squeezed,
A method is known in which insoluble matter is precipitated, the precipitate is separated, the solution is decolorized if necessary, dried, and the dried matter is crushed to produce aloe powder [New Food Industry (New Food Industry)]. Food Industry), Vol. 26, No. 4, No. 3
2 pages, 1984].

[0007] Products using aloe powder include intestinal food prepared by adding starch and lactose to frozen and ground aloe (Japanese Patent Application Laid-Open No. 61-183227), and bifidobacteria containing fibers obtained from aloe green waste. Growth promoting composition (JP-A-7-327635), pellets obtained by mixing collagen, gelatin and the like with aloe vera juice (Japanese Patent Application Laid-Open No. 7-502)
735) and the like.

A tablet containing an aloe powder is prepared by adding sugars to an aloe concentrate to form a solid, washing with ethanol, removing aloin, pulverizing the powder, and compressing the tablet (Japanese Patent Application Laid-Open No. 50-1979). No. 155664), 30-50% (by weight) of aloe powder is added to Reishi powder and granulated.
The granules obtained by drying and sieving are tableted, and have a hardness of 3 to 5 kg.
/ Cm ² (JP-B-8-32232) and the like, but tablets containing lactulose as an ingredient are not known.

In general, tablets are easy to take as a single unit of measure, are easy to take, and are relatively easy to produce, and are used in many pharmaceuticals, health foods and the like. Tablets are packaged and then packaged and transported. In this process, the tablets are subjected to considerable external force such as vibration and impact. Tablets must be made to be strong.

[0010] When a tablet containing aloe is to be ingested by chewing, if the tablet does not have a certain degree of hardness, the tablet adheres to the oral cavity such as teeth by chewing, causing a decrease in texture, and its palatability is remarkably reduced.

Although several types of tablets containing aloe are already commercially available, the hardness is about 3 to 4 kg in the horizontal direction and about 2 to 3 kg in the vertical direction, and the hardness is extremely low. There was a major problem and the texture was extremely poor.

As described above, when a composition containing a conventional aloe is tableted by a conventional method to produce a tablet, there is a problem that the tablet has low hardness, is extremely brittle, and has an extremely poor texture. Was.

[0013]

DISCLOSURE OF THE INVENTION The present inventors have studied starches such as corn starch, which are known excipients for aloe,
Many sugars such as lactose and sucrose were added to produce tablets in a conventional manner, but only tablets with low hardness were obtained.

Further, the present inventors granulate the entire raw material mixture of tablets or a partial mixture of tablet raw materials into granules,
I tried tableting by a conventional method. In this case, the hardness was increased as compared with the case where the powdered raw material was directly compressed, and the tablet strength was improved. However, it was still insufficient as a stable tablet that could withstand distribution as a commercial product.

As one of means for increasing the hardness of the tablet,
It is also known to increase the tableting pressure (Basic Drug Development Course II, Tablet Manufacturing, page 156, Jinjinkan, 197).
1 year). However, in tableting of a composition containing lactoferrin, excessive tableting pressure may cause capping (peeling off the upper surface of the tablet) and lamination (lamellar peeling) during tableting.
In the case of tableting a composition containing live bacterial powder of lactic acid bacteria, there is a problem that the surviving number of live bacteria is reduced.

In view of the above prior art, the present inventors have conducted intensive research to solve the problems of the above prior art.
By substituting lactoferrin of the earlier application with aloe,
The present inventors have found that tablets having extremely high hardness can be obtained, and have completed the present invention.

An object of the present invention is to provide a tablet containing aloe powder and lactulose as active ingredients, which has high hardness, does not disintegrate by transportation, and can be taken very easily.

[0018]

Means for Solving the Problems A first invention of the present invention for solving the above problems is an aloe tablet containing aloe powder and lactulose as active ingredients, and the hardness of the aloe tablet in the horizontal and vertical directions is as follows: Desirable embodiments are that each of them weighs 6 to 15 kg and that lactulose is contained in a proportion of at least 0.1 part (weight) with respect to 1 part (weight) of aloe powder.

A second invention of the present invention for solving the above-mentioned problems is a aloe powder, lactulose, a microorganism belonging to the genus Bifidobacterium, a microorganism belonging to the genus Lactobacillus, a microorganism belonging to the genus Streptococcus, or a genus belonging to the genus Pediococcus. An aloe tablet containing, as an active ingredient, a mixture of one or more microbial powders of microorganisms selected from the group consisting of microorganisms and microorganisms belonging to the genus Ryukonostoc. The hardness is 6 to 15 kg, and at least 0.1 part of lactulose (weight; hereinafter the same unless otherwise specified) with respect to 1 part (weight) of aloe powder.
In a preferred embodiment, the content is contained at the ratio of

Next, the present invention will be described.

[0021]

BEST MODE FOR CARRYING OUT THE INVENTION The aloe powder and lactulose used in the first and second inventions of the present invention are commercially available or manufactured by a known method (for example, the method described in the section of the prior art). You can also. For example, a commercially available aloe powder is manufactured as follows (quoted from a pamphlet of Sano Corporation).

The fresh leaves of aloe are thoroughly washed to remove foreign substances and decayed leaves, the leaf meat from which the leaf epidermis has been removed is crushed, the fibers are filtered off, and the enzyme is deactivated by heating to about 90 ° C. After removing the acne, the resulting leaf juice is rapidly cooled and concentrated, and the concentrated leaf juice is freeze-dried to obtain an aloe powder.

Lactulose can be produced, for example, by the method disclosed in JP-A-3-169888 and JP-A-6-228179 as follows.

Sodium hydroxide is added to a 10% aqueous lactose aqueous solution, the mixture is heated at a temperature of 70 ° C. for 30 minutes, cooled, and then the cooled solution is purified by ion exchange resin and concentrated. Cool, crystallize and remove unreacted lactose to obtain an aqueous lactulose solution with a solids content of about 68% (lactulose in solids about 79%). The aqueous solution was passed through a column packed with a strongly acidic ion exchange resin, and a fraction containing lactulose was collected and concentrated to a solid content of about 68%.
A purified lactulose aqueous solution (about 86% lactulose in solid content) is obtained (method described in JP-A-3-169888).

Further, the lactulose aqueous solution (syrup) obtained by the above method is concentrated to a solid content of about 72%,
The concentrate is cooled to 15 ° C., lactulose trihydrate crystals are added as seed crystals, and the mixture is gradually cooled to 5 ° C. over 7 days with stirring to form crystals, and after 10 days, supernatant is added. Crystals are separated from the liquid containing crystals in which the solid content of the liquid has dropped to about 61% by a filter centrifuge, washed with cold water at 5 ° C., and dried to obtain lactulose crystals having a purity of 95% or more. (The method described in JP-A-6-228179).

The lactulose used in the present invention is desirably as pure as possible, particularly preferably 95% or more.

The aloe powder produced as described above is used in an amount of 5 to 900 mg, preferably 50 to 80 mg per 1 g of tablet.
0 mg. In the present invention, lactulose is contained in a proportion of at least 0.1 part, and at most 100 parts, preferably 0.2 to 10 parts, per part of aloe powder.

In the first invention and the second invention of the present invention, other components such as lubricants such as sucrose fatty acid ester and glycerin fatty acid ester, sugars, sweeteners and flavors for improving flavor and texture are provided. , A thickener, an emulsifier, and the like are added in a prescribed amount to prepare a tablet raw material.

The raw material of the tablet can be pulverized by a known pulverizer [for example, a rotary pin mill (manufactured by Hosokawa Micron Co., Ltd.) or the like].・ O-Mix (manufactured by Hosokawa Micron), etc., and a fluidized bed granulator [eg, Glatt fluidized granulation dryer (manufactured by Okawara Seisakusho) etc.] and the like are granulated into granules using a known granulator. It can also be tableted. However, it is desirable not to granulate lubricants, fragrances, live bacterial powder of lactic acid bacteria described below, and the like.

The tablet raw material prepared as described above is tableted by a known method and apparatus. The machine used for tableting is
It is a powder compression tableting machine, and any of a well-known rotary tableting machine, eccentric tableting machine and the like can be used. For production on an industrial scale, a rotary tableting machine is used. It is desirable to use Specifically, for example, the raw material of the tablet prepared as described above is supplied to a rotary tableting machine [for example, an HT-PA type small high-speed tableting machine (manufactured by Hata Iron Works) or the like] to obtain a desired tablet shape. The tablet can be obtained by compressing and molding between the upper and lower punches having
The compression pressure at the time of tableting varies depending on the composition of the tablet material, tablet shape, tableting speed, type of tableting machine, etc., but usually 1 ton or more,
The range is 5 tons or less. Immediately before the tableting, the tablet raw material can be pre-compressed at a pressure of about 1 ton.

As for the tablet shape, in the case of an extremely irregular shape, the strength may be slightly reduced, but a round shape, a triangle shape, a polygonal shape, a football shape, a buccal shape, a flower shape, a heart shape which are generally used as a tablet shape are available. Tableting.

The bacterial powder of the lactic acid bacteria used in the second invention of the present invention may be either live bacterial powder or dead bacterial powder.
Viable bacterial powder is desirable since it has an intestinal function in vivo. The powder of the lactic acid bacteria can be commercially available or can be prepared by a known method (for example, the method described in JP-A-1-221319). For example, preculture of a desired bacterial species can be mentioned. Is cultivated in a large amount by a conventional method, and various kinds of sugars, amino acids, starch, gelatin, a dispersion medium having a protective action such as skim milk powder are added to the bacteria isolated from the culture solution, if necessary, and the resultant is freeze-dried. Cells can be prepared. A more detailed method for preparing the powder of lactic acid bacteria is as described in Reference Examples 1 to 4 described below.

The second invention of the present invention has a great advantage that a large amount of lactic acid bacteria can be contained in a tablet in a viable state, since it is not necessary to apply an excessive tableting pressure.

The tablets of the first and second inventions of the present invention produced as described above have high hardness and abrasion resistance, so that they can be packaged in bottles, cans, bags, blister packs and the like. Regardless of the form, these can be filled and packaged, and breakage and collapse during transportation can be prevented.

As described above, since the tablets of the first invention and the second invention of the present invention contain lactulose, they do not necessarily contain aloe powder, but can be either horizontally or vertically. Has a high hardness of 6 to 15 kg, can withstand the shock of handling and transportation during tableting and packaging, and can not only improve productivity and product quality, but also into the oral cavity during ingestion. It is also excellent in taste, such as no adhesion, and has features not found in conventional products.

Next, the present invention will be described with reference to test examples. Test Example 1 This test was performed to compare the effect of lactulose on tableting of aloe powder-containing tablets with the case where other sugar alcohols, erythritol and maltitol, were added.

1) Preparation of Sample As a lubricant, 97 parts of a mixture obtained by mixing 0.5 part of lactulose powder (manufactured by Morinaga Milk Industry Co., Ltd.) with 1 part of aloe powder (manufactured by Sano Corporation, UP200) 3 parts of glycerin fatty acid ester (manufactured by Riken Vitamin Co., Ltd.) was added and mixed uniformly to prepare a tablet raw material (sample 1).

Separately from this, 0.5 parts each of erythritol powder (manufactured by Niken Kagaku) and maltitol powder (manufactured by Towa Kasei Kogyo) are added to 1 part of aloe powder (manufactured by Sano Corporation, UP200). Glycerin fatty acid ester (manufactured by Riken Vitamin Co., Ltd.) (3 parts) was added as a lubricant to 97 parts of the mixture blended in the above ratio, and the mixture was uniformly mixed to prepare tablet raw materials (Samples 2 and 3).

Each sample was mounted on a rotary table type tableting machine (manufactured by Hata Iron Works) with a round tablet punch having a diameter of 10 mm, and each sample was tableted at a tableting pressure of 2 tons. 500 round tablets each weighing 0.5 g were prepared.

2) Test method Thirty tablets were randomly sampled from each of the obtained samples, and the hardness of each tablet was measured in a horizontal direction and a vertical direction using a digital hardness tester (manufactured by Kiya Seisakusho). Was calculated and a hardness comparison test was performed.

3) Test Results As a result of this test, the tablet (sample 2) using erythritol was extremely fragile, and the average hardness was 0.5 kg in the horizontal direction and 0.3 kg in the vertical direction. The average hardness of the tablet (sample 3) using maltitol, which is generally used as the excipient, was higher than that of sample 1, 3.0 kg horizontally and 1.2 kg vertically.

On the other hand, the average hardness of the tablet to which lactulose was added (sample 1) was 10 kg in the horizontal direction and 8 kg in the vertical direction, and it was confirmed that the use of lactulose significantly increased the hardness of the tablet.

The test was conducted by changing the type of aloe powder, lactulose, and tableting machine, and almost the same results were obtained.

Test Example 2 This test was conducted to determine the ratio of aloe powder and lactulose suitable for tableting.

1) Test Method A mixture 97 in which 0 parts to 0.95 parts of lactulose powder (manufactured by Morinaga Milk Industry Co., Ltd.) was mixed with 1 part of aloe powder (manufactured by Sano Corporation, UP200) as shown in Table 1. A 0.5 g round tablet was prepared per tablet in the same manner as in Test Example 1 except that the parts were used. Separately from this, Test Example 1 was conducted except that 97 parts of lactulose powder (manufactured by Morinaga Milk Industry Co., Ltd.) was used without blending aloe powder.
A round tablet of 0.5 g per tablet was prepared in the same manner as described above.

2) Test Method The average hardness was measured and tested in the same manner as in Test Example 1.

3) Test results The results of this test are as shown in Table 1. As is clear from Table 1, the addition of 0.1 parts or more of lactulose to 1 part of aloe powder gives tablets having a tablet hardness (average of 4 kg in the horizontal direction and average of 3 kg in the vertical direction) that can withstand the impact of transportation or the like. , 0.2 parts or more, a strong tablet having a hardness of 6 kg or more on average in the horizontal direction and 6 kg or more on the vertical direction was obtained. When 100 parts of lactulose was added to 1 part of aloe powder, the hardness of the tablet was 15 kg on average in both the horizontal and vertical directions,
Tablets close to those without lactoferrin (average 16 kg in both horizontal and vertical directions) were obtained.

In each of the obtained tablets, when the amount of lactulose added was less than 0.08 parts per 1 part of aloe powder, capping was observed in all samples.
Almost no adhesion was observed when 1 part was added, and no adhesion was observed when 0.2 part or more was added.

Therefore, at least 0.1 part, preferably 0.2 to 1 part of lactulose is used per part of aloe powder.
It has been found that by adding 0 parts, a strong tablet having a hardness of 6 to 15 kg in both the horizontal direction and the vertical direction can be obtained.

The test was conducted by changing aloe powder, lactulose, and the type of tableting machine, and almost the same results were obtained.

[0051]

[Table 1]

Test Example 3 This test was conducted to examine the effect of tableting on the viable cell count of the tablet of the present invention containing viable cells.

1) Preparation of Sample Bifidobacterium was added to 95 parts of a mixture obtained by mixing 0.5 part of lactulose powder (manufactured by Morinaga Milk Industry Co., Ltd.) with 1 part of aloe powder (manufactured by Sano Corporation, UP200). -Cell powder of longum (Bifidobacterium longum) M-8201 (Publication No. 6548) (viable cell count: 100 x 10)
⁸ / g. 2 parts of Morinaga Milk Industry Co., Ltd. and 3 parts of glycerin fatty acid ester (manufactured by RIKEN Vitamin Co.) as a lubricant were added and mixed uniformly to prepare a tablet raw material (viable cell count: 2 × 10 ⁸ / g). (Sample 4).

Separately from this, a mixture 95 in which maltitol powder (manufactured by Towa Kasei Kogyo Co., Ltd.) is blended at a ratio of 0.5 part to 1 part of aloe powder (manufactured by Sano Corporation, UP200).
2 parts of bacterial cell powder of Bifidobacterium longum (viable cell count: 100 × 10 ⁸ / g; manufactured by Morinaga Milk Industry Co., Ltd.) and 3 parts of glycerin fatty acid ester (manufactured by Riken Vitamin Co.) as a lubricant The mixture was uniformly mixed to prepare a tablet raw material (viable cell count: 2 × 10 ⁸ / g) (sample 5).

A rotary tableting machine (manufactured by Hata Iron Works) was fitted with a round tablet punch having a diameter of 10 mm, and each sample was tableted at a tableting pressure of 2 tons to obtain a round tablet having a weight of 0.5 g. Each 500 tablets were prepared.

2) Test method The average hardness was measured and tested by the same method as in Test Example 1.

From the tablets of each sample obtained, 10 tablets were randomly collected, the viable count of bifidobacteria in each tablet was measured by the pour culture method, and the average value of each sample was calculated. A comparative test of the number of bacteria was performed.

3) Test results The results of this test are as shown in Table 2. As is clear from Table 2, in the case of lactulose addition (sample 4),
While the tablets were firm (with an average of about 10 kg in the horizontal direction and an average of about 8 kg in the vertical direction) with almost no decrease in the number of viable bacteria, the number of viable cells in the tablets with maltitol (sample 5) was reduced by lactulose. Although hardly decreased as in the case of the above, the hardness was about 3 kg in the horizontal direction and about 1 kg in the vertical direction, and was extremely fragile.

Therefore, by compressing raw materials consisting of live bacterial powder of lactic acid bacteria, aloe powder and lactulose,
It has been found that strong tablets can be produced with almost no decrease in the viable cell count.

The aloe powder, the lactulose and the viable bacterial powder, and the type of the tableting machine were tested, and almost the same results were obtained.

[0061]

[Table 2]

Reference Example 1 Bifidobacterium longam
gum) M-8201 (Microtechnical Laboratories No. 6548) was subcultured for 10 generations using an ABCM medium (manufactured by Eiken Chemical Co., Ltd.) supplemented with glucose, and then glucose, yeast extract, peptone and phosphate were added. 50 l of synthetic medium consisting of
The cells were cultured at a temperature of 7 ° C. for 14 hours. The resulting culture was centrifuged to collect the cells, and 100 g of glutamic acid (manufactured by Wako Pure Chemical Industries, Ltd.) and 500 ml of a dispersion medium in which 50 g of sucrose were dissolved in water were added to 1 liter of the obtained bacterial solution, followed by freeze-drying. .

To 275 g of the obtained powdered bacterial cells, 2 kg of lactose (manufactured by Wako Pure Chemical Industries, Ltd.) and 2.5 kg of dried cornstarch (manufactured by Matsutani Chemical Industry Co., Ltd.) were added, mixed and dispersed, and mixed with Bifidobacterium. About 4.7 kg of powdered cells of longum (viable cell count: 110 × 10 ⁸ / g) were obtained.

Reference Example 2 Streptococcus faeca
lis) Except for using ATCC-19433, in the same manner as in Reference Example 1, about 4.0 kg of powdered cells of Streptococcus faecalis (viable cell count: 230 × 10 ⁸ /
g) was obtained.

Reference Example 3 Lactobacillus acido
philus) Approximately 4.5 kg of powdered cells of Lactobacillus acidophilus (viable cell count: 340 × 10 ^{8) in} the same manner as in Reference Example 1 except that ATCC-4356 was used.
/ G).

Reference Example 4 Leuconostoc cremori
s) Reference Example 1 except that ATCC-19254 was used.
According to the same method as described above, about 3.5 kg of powdered cells of Ryukonostoc cremoris (viable cell count: 50 × 10 ⁸ / g)
I got

Next, the present invention will be described more specifically with reference to examples, but the present invention is not limited to the following examples.

[0068]

Example 1 40 kg of aloe powder (manufactured by Sano Corporation, UP200), 40 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.), 8.5 kg of erythritol (manufactured by Niken Kagaku), 8 kg of maltitol (manufactured by Towa Kasei Kogyo) , Stevia (Nippon Paper Industries) 0.1
kg, glycerin fatty acid ester (manufactured by RIKEN Vitamin Co., Ltd.)
3kg and yogurt flavor (manufactured by Hasegawa Inc.)
0.4 kg was uniformly mixed, and the mixture was tableted at a tableting pressure of 2 tons using a rotary table-type tableting machine (manufactured by Hata Iron Works) to obtain 195,000 triangular tablets with 0.5 g per tablet.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 10 kg, and the average in the vertical direction was 9 kg.

Example 2 Aloe powder (manufactured by Sano Corporation; WP200) 72.0k
g, lactose (manufactured by Morinaga Milk Industry Co., Ltd.) except that 8.0 kg was used, to obtain 195,000 0.5 g triangular tablets per tablet in the same manner as in Example 1.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 6 kg and the average in the vertical direction was 6 kg.

Example 3 Aloe powder (manufactured by Sano Corporation, UP200) 65.0k
g, and 15,000 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.) was used.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 7 kg, and the average in the vertical direction was 7 kg.

Example 4 0.8 kg of aloe powder (UP200, manufactured by Sano Corporation)
Except that 80 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.) was used, the same method as in Example 1 was used to obtain 0.1 g of lactose per tablet.
55,000 triangular tablets of 195,000 were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 14 kg, and the average in the vertical direction was 13 kg.

Example 5 30 kg of aloe powder (manufactured by Sano Corporation; WP200), 30 kg of lactulose (manufactured by Morinaga Milk Industry), 8.5 kg of xylitol (manufactured by Towa Kasei Kogyo), 8 kg of maltitol (manufactured by Towa Kasei Kogyo), Stevia (Nippon Paper Industries) 0.
1 kg, 20 kg of bacterial powder of Bifidobacterium longum manufactured by the same method as in Reference Example 1, 3 kg of glycerin fatty acid ester (manufactured by RIKEN Vitamin Co.) and 0.4 kg of yogurt flavor (manufactured by Hasegawa Koryo Co., Ltd.) are uniformly mixed. Using a rotary table type tableting machine (manufactured by Hata Iron Works) at a tableting pressure of 2 tons, 195,000 triangular tablets with 0.5 g per tablet were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 10 kg, and the average in the vertical direction was 9 kg. The viable cell count is 22 × 1 before tableting.
0 ⁸ / g, and 21 × 10 ⁸ / g after tableting.

Example 6 Aloe powder (manufactured by Sano Corporation, UP200) 54.6k
g, and 55,000 kg of triangular tablets were obtained in the same manner as in Example 5 except that 5.46 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.) was used.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 6 kg, and the average in the vertical direction was 6 kg. The viable cell count was 22 × 10 before tableting.
⁸ / g, and 20 × 10 ⁸ / g after tableting.

Example 7 Aloe powder (manufactured by Sano Corporation, UP200) 50.0k
g, and 195,000 tablets of 0.5 g per tablet were obtained in the same manner as in Example 1, except that 10.0 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.) was used.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 6 kg, and the average in the vertical direction was 6 kg. The viable cell count was 22 × 10 before tableting.
⁸ / g, and 21 × 10 ⁸ / g after tableting.

Example 8 0.2 kg of aloe powder (manufactured by Sano Corporation, UP200)
Except that 20 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.) was used, the same method as in Example 1 was repeated to obtain 0.1 mg / l tablet.
54,000 triangular tablets of 64,000 were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 15 kg and the average in the vertical direction was 15 kg. The number of viable bacteria is 22 × before tableting.
It was 10 ⁸ / g and 20 × 10 ⁸ / g after tableting.

Example 9 The same procedure as in Example 5 was repeated except that 20 kg of Streptococcus faecalis powder produced in the same manner as in Reference Example 2 was used. 000 tablets were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 10 kg, and the average in the vertical direction was 10 kg. The number of viable bacteria was 46 × before tableting.
It was 10 ⁸ / g, and 44 × 10 ⁸ / g after tableting.

Example 10 Lactobacillus produced by the same method as in Reference Example 3
Except that 10 kg of Acidophilus bacterial powder was used, 195,000 tablets of 0.5 g per tablet were obtained in the same manner as in Example 5.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 10 kg, and the average in the vertical direction was 9 kg. The number of viable bacteria was 68 × 1 before tableting.
0 ⁸ / g, and 62 × 10 ⁸ / g after tableting.

Example 11 The same procedure as in Example 5 was repeated except that 10 kg of Ryukonostoc cremoris microbial powder produced by the same method as in Reference Example 4 was used. 195,000 tablets were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 11 kg, and the average in the vertical direction was 9 kg. The viable count is 10 × 1 before tableting.
0 ⁸ / g, 9 × 10 ⁸ / g after tableting.

Example 12 30 kg of aloe powder (manufactured by Sano Corporation; UP200) and 30 kg of lactulose (manufactured by Morinaga Milk Industry) were mixed in advance.
Except that granulation was carried out using a fluidized-granulation dryer (manufactured by Okawara Seisakusho), 195,000 0.5 g triangular tablets were obtained per tablet in the same manner as in Example 5.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 12 kg, and the average in the vertical direction was 11 kg. The number of viable bacteria is 22 × before tableting.
It was 10 ⁸ / g and 20 × 10 ⁸ / g after tableting.

Example 13 30 kg of aloe powder (manufactured by Sano Corporation; UP200), 30 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.), 8.5 kg of erythritol (manufactured by Niken Kagaku), maltitol (manufactured by Towa Kasei Kogyo) 0kg, Stevia (Nippon Paper Industries)
0.1 kg was previously mixed and granulated using a fluidized granulating dryer (manufactured by Okawara Seisakusho Co., Ltd.) in the same manner as in Example 5, except that 0.5 g of triangular tablets 19 per tablet were used.
5,000 tablets were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 12 kg, and the average in the vertical direction was 11 kg. The number of viable bacteria is 22 × before tableting.
It was 10 ⁸ / g and 20 × 10 ⁸ / g after tableting.

Example 14 40 kg of aloe powder (manufactured by Sano Corporation, UP200), 20 kg of lactulose (manufactured by Morinaga Milk Industry Co., Ltd.), 8.5 kg of erythritol (manufactured by Niken Kagaku), maltitol (manufactured by Towa Kasei Kogyo) 0kg, Stevia (Nippon Paper Industries)
0.1 kg, 5 kg of bacteria of Bifidobacterium longum produced by the same method as in Reference Example 1, 1 kg of bacteria of Streptococcus faecalis produced by the same method as in Reference Example 2, and the same method as in Reference Example 3. 5 kg of Lactobacillus acidophilus powder produced by Ryukonostoc.
5 kg of Cremoris powder, 3.0 kg of glycerin fatty acid ester (manufactured by Riken Vitamin Co.) and 0.4 kg of yogurt flavor (manufactured by Hasegawa Koryo Co., Ltd.) are uniformly mixed, and the mixture is mixed with a rotary table type tableting machine (manufactured by Hata Iron Works). Tableting was performed under a compression pressure of 2 tons to obtain 195,000 football-shaped tablets, each weighing 0.5 g.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 9 kg, and the average in the vertical direction was 8 kg. The viable cell count was 37 × 10 before tableting.
⁸ / g, and 34 × 10 ⁸ / g after tableting.

Example 15 Aloe powder (manufactured by Sano Corporation, UP200) 5.45k
g, 54.5 kg of lactulose (manufactured by Morinaga Milk Products), 8.5 kg of erythritol (manufactured by Niken Kagaku), 8 kg of maltitol (manufactured by Towa Kasei Kogyo), and 0.1 kg of stevia (manufactured by Nippon Paper Industries). After granulation using a fluidized-granulation dryer (manufactured by Okawara Seisakusho), 5 kg of Bifidobacterium longum powder produced by the same method as in Reference Example 1 was produced by the same method as in Reference Example 2. 5 kg of Streptococcus faecalis powder, 5 kg of Lactobacillus acidophilus powder produced by the same method as in Reference Example 3, 5 kg of Ryukonostoc cremoris powder produced by the same method as in Reference Example 4, glycerin fatty acid ester ( Add 3 kg of RIKEN Vitamin Co., Ltd.) and 0.4 kg of yogurt flavor (Hasegawa Koryo Co., Ltd.) and mix uniformly. The turntable-type tablet machine (manufactured by HataTetsuko plant) at a tableting pressure of 2 tons 0.5 per tablet
g of heart-shaped tablets of 195,000 tablets were obtained.

The hardness of the obtained tablet was measured by the same method as in Test Example 1. As a result, the average in the horizontal direction was 13 kg, and the average in the vertical direction was 12 kg. The number of viable bacteria is 37 × before tableting.
It was 10 ⁸ / g, and 33 × 10 ⁸ / g after tableting.

[0098]

As described in detail above, the present invention provides
Contains aloe powder and lactulose as active ingredients, lactoferrin tablets having extremely high hardness, and aloe powder, lactulose, and powders of one or more microorganisms selected from the group consisting of lactic acid bacteria as active ingredients. However, the present invention relates to an aloe tablet having extremely high hardness, and the effects of the present invention are as follows. 1) A hard aloe powder-containing tablet having a high hardness can be produced using a conventional apparatus. 2) Aloe powder-containing tablets that are excellent in palatability and do not adhere to the oral cavity during ingestion are obtained. 3) It does not require excessive tableting pressure, so it contains a large amount of viable lactic acid bacteria despite strong aloe powder-containing tablets. 4) Capping at the time of tableting is not recognized, which is convenient for production.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Teruhiko Mizota 5-1-183 Higashihara, Zama City, Kanagawa Prefecture Morinaga Dairy Co., Ltd. Food Research Institute (72) Inventor Yuzo Asano 5-183 Higashihara, Zama City, Kanagawa Prefecture No. Morinaga Dairy Products Co., Ltd.Food Research Institute (72) Inventor Tetsushi Mori 5-183 Higashihara, Zama City, Kanagawa Prefecture Morinaga Dairy Products Co., Ltd. No. 83 Morinaga Dairy Products Co., Ltd.

Claims (6)

[Claims] 1. An aloe tablet comprising aloe powder and lactulose as active ingredients. 2. The aloe tablet according to claim 1, wherein each of the tablets has a horizontal and vertical hardness of 6 to 15 kg. 3. The aloe tablet according to claim 1, wherein lactulose is contained in a proportion of at least 0.1 part (weight) with respect to 1 part (weight) of the aloe powder. 4. A group consisting of aloe powder, lactulose, and microorganisms belonging to the genus Bifidobacterium, microorganisms belonging to the genus Lactobacillus, microorganisms belonging to the genus Streptococcus, microorganisms belonging to the genus Pediococcus, and microorganisms belonging to the genus Ryukonostoc. An aloe tablet containing, as an active ingredient, a mixture of one or more kinds of microorganisms selected from microorganisms selected from the group consisting of: 5. The aloe tablet according to claim 4, wherein the hardness of each of the tablets in the horizontal and vertical directions is 6 to 15 kg. 6. The aloe tablet according to claim 4, wherein lactulose is contained in a proportion of at least 0.1 part (weight) with respect to 1 part (weight) of the aloe powder.