JPH11158052A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition having an excellent tartar-preventing effect and high safety by including a non-cationic antibacterial substance and a polycarboxylic acid (salt) derived from a polysaccharide comprising anhydrous glucose molecules as constituting units. SOLUTION: This composition for oral cavities comprises (A) a polycarboxylic acid derived from a polysaccharide comprising anhydrous glucose molecules as constituting units and preferably having a weight-average mol.wt. of 1,000-100,000 or its salt and (B) a non-cationic antibacterial substance [for example, 2,4,4'-trichloro-2-hydroxydiphenyl ether (triclosan)]. The components A and B are preferably contained in amounts of 0.01-10 wt.% and 0.01-5 wt.% in the composition. The component A especially has an activity to inhibit the production of hydroxyapatite, and the component B exhibits a strong antibacterial activity against oral bacteria forming dental plaques which are the precursors of tartar.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a highly safe oral composition having an improved anti-calculus effect.

[0002]

2. Description of the Related Art Calculus is a calcareous deposit deposited on the tooth surface, the interdental region, or the gingival margin, and greatly impairs the appearance of the oral cavity. In addition, tartar has an extremely rough surface, which promotes the colonization of oral bacteria or the adhesion of plaque, which is said to be a factor of accelerating various oral diseases.

Although the details of the calculus formation process are not always clear, calcium supplied from saliva and exudate to bacteria or dextran-forming organic substances constituting plaque present on the tooth surface is not clearly understood. This can be considered as a calcification phenomenon of plaque in which phosphorus is adsorbed and crystallized. The inorganic component is a calcified substance like hydroxyapatite. Accordingly, the formation of tartar can be suppressed by suppressing the calcium phosphate deposited in the plaque from transferring to hydroxyapatite crystals and further growing.

[0004] Based on this idea, the effect of soluble phosphate on the prevention of tartar formation has been reported [Archive Oral Biology (Arch. O).
ral. Biol. ) Vol. 15, p893-896
(1970)]. Further, JP-A-52-108029 and JP-A-59-42311 disclose methods of preventing tartar by condensed phosphates such as pyrophosphate and polyphosphate.
JP-A-49-118839, JP-A-4-3343
No. 14 proposes a method for preventing tartar using a diphosphonate compound having a chemical structure similar to that of condensed phosphoric acid.

[0005] However, condensed phosphate has a problem in that its effectiveness is reduced by phosphoric acid hydrolase in the oral cavity.
Complicating product formulations to maintain efficacy. Further, diphosphonate compounds have not been put to practical use because of their high calcium elution properties.

[0006] A method has also been proposed for improving the effect of preventing tartar by using an antibacterial substance that suppresses the formation of plaque, which is a precursor of tartar, in combination. For example, US Pat.
No. 80 discloses a combination of a compound that provides zinc ions as an anticalculus substance and an antibacterial substance. JP-A-63-2
No. 58404 describes the use of condensed phosphate and a non-cationic antibacterial substance as anti-calculus substances.

However, when zinc ions are incorporated in a large amount, there are problems such as deterioration of taste and reaction with a fluorine compound commonly used in oral compositions.

[0008] Non-cationic antibacterial substances have been applied to oral compositions for various purposes because of their good compatibility with other components. For example, 2,4,4'-trichloro-2-hydroxydiphenyl ether (triclosan) is disclosed in
Japanese Patent Application Publication No. 0-239409 discloses an effect of suppressing plaque formation when used in combination with a surfactant that forms lamellar liquid crystals. Regarding the combined use of triclosan and an anionic polymer, see JP-A-2-288819 and JP-A-6-288819.
JP 1920060 discloses an increase in antibacterial activity when used in combination with a polyvinyl carboxylic acid-based polymer, polyvinyl phosphonic acid-based polymer, or a synthetic cross-linked anionic polymer. Improvement of oral retention by combination with polysaccharides such as alginate, pectin, cyclodextrin or chitin is proposed, and improvement of oral retention by combination with alginic acid and xanthan gum is proposed in JP-A-7-187975. Have been. However, these all relate to the antibacterial activity of triclosan, and no mention is made of the effect of inhibiting tartar formation.

The oxidation products of polysaccharides are described in
JP-A-9-1281, JP-A-60-226502, JP-A-62-247837, JP-A-4-17
No. 5,301, JP-A-4-233901, etc., but there is no description on the effect of hydroxyapatite on inhibiting crystal formation and calculus formation.

As described above, various oral compositions having an effect of inhibiting calculus formation have been proposed. However, in recent years, development of an oral composition having a higher anti-calculus effect has been reflected in view of increasing awareness of oral hygiene. Is desired.

On the other hand, considering that the oral composition is used in the oral cavity of a human, in addition to high safety, good taste,
An important characteristic is that it has no effect on taste. When inorganic salts such as condensed phosphates are blended in a large amount, there is a problem that unpleasant tastes such as saltiness and bitterness are exhibited.

The present invention has been made in view of the above circumstances,
An object of the present invention is to provide an oral composition which has high antibacterial activity against bacteria forming plaque, has excellent hydroxyapatite crystal formation inhibitory activity, has a high tartar prevention effect, and is highly safe. .

[0013]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to achieve the above object, and as a result, a polycarboxylic acid derived from a polysaccharide having anhydrous glucose as a structural unit has been obtained. Or that the salt thereof has excellent hydroxyapatite crystal formation inhibitory activity, and further by using a non-cationic antibacterial substance having a high antibacterial activity against oral bacteria forming plaque which is a precursor of tartar, They have found that more effective prevention of tartar can be achieved, and have completed the present invention.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention includes toothpastes such as toothpaste, lubricating toothpaste, liquid dentifrice, mouthwashes, chewing gum, gargle tablets, denture cleaners and the like. Prepared and applied as a non-cationic antibacterial with one or more selected from polycarboxylic acids or salts thereof derived from a polysaccharide having anhydrous glucose as a constituent unit as an active ingredient for inhibiting calculus formation And a substance as essential components.

The polycarboxylic acid or its salt derived from a polysaccharide having anhydrous glucose as a structural unit used in the present invention is obtained by oxidizing the above polysaccharide with an existing oxidizing agent. However, it is preferable to use those synthesized by a method of oxidizing with an oxidizing agent such as hypohalite or salad powder in the presence of a transition metal catalyst.

Here, the polysaccharide having anhydrous glucose as a constitutional unit is not particularly limited. For example, starch, dextrin, cellulose, or a hydrolyzate thereof may be used.
Or amylose or amylopectin obtained by fractionating starch, and these can be used alone or in combination of two or more. The origin of these polysaccharides is not particularly limited.For example, in the case of starch, corn starch, wheat starch, rice starch, tapioca starch and the like, and in the case of cellulose, cellulose obtained from conifers, hardwoods, cotton, etc. Can be used. Of these polysaccharides, use of starch or cellulose is preferred from the viewpoint of availability and economy, and starch is particularly preferred.

As the transition metal catalyst, for example, Ru, O
Examples thereof include s, Rh, Ir, Pt, and Pd, and are preferably a ruthenium catalyst or an osmium catalyst. These metal catalysts may be used in the form of chlorides, sulfides, oxides or the like, or may be used as the metal element.

The transition metal catalyst is used in an amount of 0.05 to 10 mol%, preferably 0.1 to 10 mol%, based on anhydrous glucose units of the polysaccharide.
1 to 7 mol% is preferred.

As the oxidizing agent, use is preferably made of hypohalite (eg, Na salt, K salt, Ca salt, Mg salt, etc.) or ash powder, particularly preferably hypohalite.

The amount of the oxidizing agent depends on the content of the carboxyl group in the polycarboxylic acid to be finally obtained. The molar ratio is preferably up to 9 times.

The polycarboxylic acid or its salt derived from a polysaccharide having anhydrous glucose as a structural unit used in the present invention is obtained by dispersing a polysaccharide having anhydrous glucose as a structural unit and a transition metal catalyst in water. The dispersion can be produced by adding the oxidizing agent while keeping the pH of the dispersion in a certain range. In this case, the oxidizing agent is usually added continuously or dividedly.

The conditions of the above oxidation reaction are not particularly limited, but may be usually 10 to 50 ° C. for 2 to 8 hours.

The pH during the reaction is from 6 to 13, especially from 7 to 13.
It is preferable that the ratio be kept in the range of 12. Adjustment of pH
For example, sodium hydroxide, potassium hydroxide, hydroxides of alkali metals such as lithium hydroxide, ammonia, alkylamines, amines such as alkanolamines can be used, particularly sodium hydroxide, potassium hydroxide Use is preferred.

The polycarboxylic acid derived from a polysaccharide having anhydrous glucose as a constitutional unit may be used whether the carboxyl group is in the form of an acid or in the form of a salt with an alkali metal, ammonium or amine. it can. Specific examples of the salt include alkali metal salts such as Na, K, and Li, ammonium salts, and amine salts such as alkylamines and alkanolamines. Is preferred. Further, only a part of the carboxyl group may be in the form of a salt.

The polycarboxylic acid derived from a polysaccharide having anhydrous glucose as a constitutional unit can have a weight-average molecular weight and an average number of carboxyl groups introduced per glucose unit before the reaction by appropriately selecting reaction conditions. It can be changed appropriately.

The above-mentioned polycarboxylic acid or salt thereof is not particularly limited in the average number of carboxyl groups introduced per anhydroglucose unit before the reaction, but sodium hydroxide required for neutralization titration of acid-type polycarboxylic acid is required. However, the amount is preferably 417 mg or more, particularly 435 mg or more per 1 g of polycarboxylic acid, and if it is less than 220 mg, a satisfactory hydroxyapatite crystal formation suppressing effect may not be obtained.

The weight average molecular weight of the polycarboxylic acid or salt thereof is not particularly limited, but is preferably from 1,000 to 100,000, particularly preferably from 2,000 to 20,000. The weight average molecular weight is less than 1000 or 100000
If it becomes larger, the tartar prevention effect may decrease.

Although the polycarboxylic acid obtained in the present invention has a complicated structure, it is difficult to show a definite structural formula. However, when starch is used as a raw material, the general formula shown below is: Expressed as 1) and estimated from the amount of sodium hydroxide required for the neutralization titration, it can be said that the polycarboxylic acid has an average of 2.1 carboxyl groups per anhydroglucose unit.

[0029]

Embedded image

The reason is that, for example, C _{2 of} anhydrous glucose
-C ₃ bonds polycarboxylic acids having two carboxyl groups per anhydroglucose caused by oxidative cleavage (i.e.,
In the case of dicarboxylic polysaccharide, which corresponds to the above structural formula p = 0, n = 0), the amount of sodium hydroxide required for the neutralization titration is only 417 mg per 1 g of the acid-type polycarboxylic acid.

The amount of the polycarboxylic acid or salt thereof is not particularly limited, but may be 0.01 to 10 parts by weight based on the whole composition.
% By weight, more preferably 0.05 to 5% by weight.
It is. If the amount is less than 0.01% by weight, the hydroxyapatite crystal formation inhibitory activity may not be sufficient, and if it exceeds 10% by weight, the stability of the oral composition may be deteriorated.

Examples of the non-cationic antibacterial substance which is another essential component of the present invention include halogenated diphenyl ether, halogenated salicylanilide, benzoic acid ester, halogenated carbanilide and phenol compound. Yes, but not limited to those described here. The non-cationic antibacterial substances can be used alone or as a mixture of two or more. Of these non-cationic antimicrobial substances,
Nonionic antimicrobial agents are preferred, especially halogenated diphenyl ethers such as 2,4,4'-trichloro-2-hydroxydiphenyl ether (triclosan)
The use of is preferred.

The amount of the non-cationic antibacterial substance is not necessarily limited, but may be 0.01 to 5% by weight based on the whole composition.
Is more preferable, and more preferably 0.05 to 0.5% by weight. If the amount is less than 0.01% by weight, a satisfactory effect may not be exhibited. If the amount exceeds 5% by weight, the use feeling or taste of the composition may be adversely affected.

The composition for oral cavity of the present invention is in the form of dentifrice such as toothpaste, lubricating toothpaste, liquid dentifrice, mouthwash, mouthwash, gargle tablet, denture cleaner, chewing gum and the like. Each composition can be prepared by a usual method using other components according to the characteristics within a range not to impair the effects of the present invention. As an optional component, for example, when preparing a dentifrice, calcium hydrogen phosphate dihydrate,
Abrasives such as calcium hydrogen phosphate anhydride, calcium carbonate, aluminum hydroxide, aluminum oxide, and silicic acid; thickeners such as glycerin, sorbite, and propylene glycol; binders such as sodium carboxymethyl cellulose, carrageenan, and xanthan gum; Surfactants such as sodium lauryl sulfate, sweeteners such as saccharin, other preservatives, flavors, coloring agents, pH adjusters, excipients, various medicinal ingredients and the like can be added.

[0035]

According to the present invention, one or more polycarboxylic acids or salts thereof derived from a polysaccharide having anhydrous glucose as a constitutional unit, and a non-cationic antibacterial substance are essential components. As a result, while exhibiting high antibacterial activity against bacteria forming plaque, which is a precursor of tartar, it has a high hydroxyapatite crystal formation inhibitory activity, and has an extremely excellent tartar prevention effect, and furthermore, on safety An oral composition with no problem can be obtained.

[0036]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples, "weight average molecular weight" is abbreviated as "MW" and "carboxyl group content" is abbreviated as "C content".

[Experimental Example 1] A stirrer, an oxidizing agent dropping funnel,
In a 500 mL separable flask equipped with a sodium hydroxide aqueous solution dropping port, a pH electrode, and a thermometer, 10 g of corn starch in absolute dry weight and 100 parts of ion-exchanged water were added.
g and RuCl ₃ .nH ₂ O (Ru content 38% by weight)
0.49 g (3 mol% based on the anhydrous glucose units of the starch) was weighed. Then, the mixture was cooled in a water bath at 20 ° C., and when the internal temperature reached 20 ° C., 230 g of a 12% by weight aqueous solution of sodium hypochlorite (6 times mol based on anhydrous glucose units of starch) was added over 3 hours. . During this time,
Using a pH stat, 2N aqueous sodium hydroxide was added to control the pH in the system to 9.

After the addition of sodium hypochlorite, stirring was continued for a further 2 hours, then the reaction mixture was slowly poured into about 1 L of ethanol to precipitate the reaction product. The obtained precipitate was dissolved in 150 mL of ion-exchanged water, purified by performing diffusion dialysis with ion-exchanged water for 5 days, and then freeze-dried to obtain 7.5 g of sodium salt of polycarboxylic acid (1).
I got

With respect to the obtained sodium polycarboxylate (1), the C content determined by the following method was 52.
1 mg and MW was 5800.

Further, as shown in Table 1, by changing the reaction conditions such as the kind of polysaccharide, the kind and amount of the catalyst, the kind and amount of the oxidizing agent, and the pH during the reaction, the polycarboxylic acid ( 2) to (7) were obtained.

Measurement of carboxyl group content (C content)
Borate-type polycarboxylic acid about 0.2g of (bone dry weight) was accurately weighed, was weighed into a conical beaker of 200mL volume, and dissolved by adding ion exchanged water about 50 mL, as an indicator phenolphthalein, It was titrated with a 1/10 normal sodium hydroxide standard solution. The C content is indicated as mg of sodium hydroxide required to neutralize 1 g of the acid-type polycarboxylic acid.

If it is clear that a part or all of the polycarboxylic acid whose C content is to be measured is in the form of a salt, an aqueous solution of about 1% by weight of the polycarboxylic acid salt is prepared, The mixture was passed through a column filled with an exchange resin (DOWEX 50W-X18) and subjected to cation exchange to convert into an acid-type polycarboxylic acid. The cation exchange resin used was 10 mL per 1 g of a 1% by weight aqueous solution of polycarboxylic acid.

Measurement method of weight average molecular weight (MW) About 5 mg of the same polycarboxylic acid powder used for the measurement of the C content was mixed with 0.1 mol / L phosphorous containing 0.3 mol / L sodium chloride. It was dissolved in 5 mL of an acid buffer (pH 7), measured by GPC under the following conditions, and expressed as a weight average molecular weight. Column used: Tosoh Corporation G-4000PW + G-25
00PW eluent: 0.1 mol / L phosphate buffer (pH 7) containing 0.3 mol / L sodium chloride Elution rate: 0.5 mL / min Column temperature: 40 ° C. Sample injection volume: 200 μL Calibration curve : Standard sodium polyacrylate manufactured by Polyscience (weight average molecular weight 2100, 5000, 200
00, 35000, 165300)

[0044]

[Table 1]

Next, as shown in Table 2, the salts of the polycarboxylic acids (1) to (7) and sodium alginate obtained by the above method were alkali-hydrolyzed, and the molecular weight distribution was adjusted to 1,000 to 10,000 by dialysis. After alkali hydrolysis of the low molecular weight sodium alginate and sodium carboxycellulose, the molecular weight distribution was reduced to 1000 to 1 by dialysis.
Low molecular weight sodium carboxycellulose, sodium polyacrylate (MW about 200,000)
And methoxyethylene-sodium maleate copolymer (MW about 70,000) using in vitro
(tro), the effect of suppressing the formation of hydroxyapatite crystals was evaluated by the following method. Table 2 shows the results.

On the formation of hydroxyapatite crystals
Inhibitory effect evaluation method The above components were added at the concentrations shown in Table 2 to 24 mL of a 4 mM sodium phosphate solution, and 1 mL of a 4 mM calcium chloride solution.
Was added, and the effect on the time until the precipitated amorphous calcium phosphate was transferred to form hydroxyapatite crystals was measured. The evaluation was performed by measuring the change over time of a 0.1 N sodium hydroxide solution dropped to replenish OH ions consumed in the transfer reaction to hydroxyapatite shown in the following reaction formula 1- (b). Was. As a control, a sodium phosphate solution to which distilled water was added instead of the above components was used. The following reaction formula 1 shows a reaction for generating hydroxyapatite from calcium ions and phosphate ions. The following reaction formula 1- (a) is a reaction for forming amorphous calcium phosphate, and the following reaction formula 1- (b) is a transfer reaction from amorphous calcium phosphate to hydroxyapatite crystals. When the calcium ion and the phosphate ion come into contact, the reaction of the formula 1- (a) occurs instantaneously, and subsequently the formula 1- (a)
The transfer reaction of (b) proceeds gradually. In all of these, OH ions are consumed as the reaction proceeds, and the solution changes to acidic. The consumption of this OH ion depends on the pH of the solution.
Can be determined by monitoring the amount of sodium hydroxide solution added from the outside in order to keep the temperature constant. FIG. 1 shows the relationship between the progress of the reaction and the amount of the sodium hydroxide solution added. Where the change is
(A) corresponds to the formation of amorphous calcium phosphate. Further, the change corresponds to a reaction in which amorphous calcium phosphate of the formula 1- (b) is transferred to form hydroxyapatite crystals.

That is, after the reaction of the formula 1- (a), the formula 1- (a)
The longer the time until the reaction (b) starts (hereinafter referred to as Thap), the more the generation of hydroxyapatite crystals is suppressed.

[0048]

(Equation 1)

[0049]

[Table 2]

From the results shown in Table 2, polycarboxylates derived from polysaccharides having anhydrous glucose as a constitutional unit (the numbers in parentheses are the numbers of the polycarboxylic acids obtained in the experimental examples; the same applies hereinafter). Is shorter than the time until the formation of hydroxyapatite crystals (Th) compared to anionic polysaccharides having a reduced molecular weight or synthetic polymer compounds having a relatively large molecular weight.
ap) was very long, and it was found to have a high hydroxyapatite crystal formation suppressing effect.

[Experimental example 2] Experimental example 1 was prepared in the following dentifrice composition.
Sodium polycarboxylate (1) and triclosan (hereinafter abbreviated as TC), thymol (hereinafter abbreviated as TH), hinokitiol (hereinafter abbreviated as HI) and chlorinated salt commonly used in oral compositions Cetylpyridinium (hereinafter abbreviated as CPC) was added as an antibacterial substance in the amount shown in Table 3. After storing these dentifrices at 40 ° C. for one week, they were diluted with water three times and centrifuged, and the in vitro antibacterial activity against various bacteria was evaluated by the following method using the supernatant as a test solution. Table 3 shows the results.

<Toothpaste composition> Silica 15% 60% sorbitol solution 25 Carboxymethylcellulose sodium 1.0 Saccharin sodium 0.15 Sodium lauryl sulfate 1.5 Sodium polycarboxylate (1) Amount shown in Table 3 Antibacterial substance Amount shown in Table 3 Purified water balance 100.0%

Test method for evaluation of antibacterial activity against oral bacteria Test tube (13 × 100 mm) containing 4 mL of liquid medium
Was added and mixed, and 0.04 mL of each bacterial solution pre-cultured for 24 hours was added and stirred. After anaerobic culture at 37 ° C. for 3 days, the amount of bacterial growth was measured by absorbance at 550 nm. Absorbance 0.
The minimum growth inhibitory concentration (MIC) was determined based on the validity of less than 05. The minimum growth inhibitory concentration of each antibacterial substance was calculated from the dilution rate of the test solution.

Strain used and composition of liquid medium Streptococcus mutans 10449 (hereinafter abbreviated as Sm) Medium: Todd Hewitt broth (hereinafter abbreviated to THB) 3% Streptococcus sangis 10558 (Streptococ) s anguiis 10558 (hereinafter abbreviated as Ss)) Medium: THB 3% Actinomyces viscosus T14V (Actinomyces vis cosus T14V (hereinafter abbreviated as Av)) Medium: THB 3% Porphyromonas rosophilus 38 m. gingivalis 381 (hereinafter abbreviated as Pg)) Medium: THB 3% Hemin 3 ppm Menadione 0.5 ppm

[0055]

[Table 3]

As shown in Table 3, the non-cationic antibacterial substance has high antibacterial activity against microorganisms involved in plaque formation even when used in combination with sodium polycarboxylate (1).

EXPERIMENTAL EXAMPLE 3 Using the sodium polycarboxylate (1) prepared in Experimental Example 1 and triclosan as a non-cationic antibacterial substance, a mouthwash having the composition shown in Table 4 was prepared. Using these gargles, the effect of inhibiting calculus formation in in situ by 20 adult men without smoking habit was evaluated by the following method. Table 4 shows the average value of the results.

Method of Evaluating the Inhibitory Effect on Calculus Formation A resin mouthpiece was prepared in which a polyester film having a fixed area was attached to the lingual side of the lower anterior teeth and attached to the center of the lingual surface. Place a mouthpiece on the lingual side of the oral cavity
It was worn for 8 hours a day, during which time the mouth was rinsed twice using a mouthwash. One mouthwash uses about 10 mL of mouthwash and 30
Seconds. After performing this operation continuously for 5 days, the amounts of calcium and amino nitrogen contained in the deposits deposited on the polyester film attached to the mouthpiece were quantified. The amount of calcium is an index of the amount of tartar, and the ratio of the amount of calcium to the amount of amino nitrogen (hereinafter abbreviated as Ca / N) is:
It serves as an index indicating the ratio of ash to organic matter in the deposit, and indicates the degree of calcification (calcification) of the deposit. That is, a decrease in the amount of calcium and a decrease in Ca / N indicate suppression of calculus formation.

[0059]

[Table 4]

As shown in Table 4, polycarboxylic acid (1)
In the experimental group using the gargle combined with sodium and triclosan, the calcium amount and Ca / N were greatly reduced compared to the experimental group using the control gargle, and a large inhibitory effect on the adhesion amount of tartar was observed. It became clear that it showed. The amount of calcium and Ca / N in the experimental group using the gargle containing sodium polycarboxylate (1) or triclosan alone as the active ingredient were also compared to the experimental group using the control gargle.
Although the decrease was observed, the inhibitory effect was smaller than when both were used in combination, and a synergistic improvement in the tartar inhibitory effect was observed by using both together.

Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples.

Example 1 Toothpaste Calcium hydrogen phosphate dihydrate 50% by weight Glycerin 20 Propylene glycol 5.0 Sodium carboxymethylcellulose 1.0 Sodium lauryl sulfate 1.5 Saccharin sodium 0.2 Fragrance 1.0 Paraben 0 .1 Sodium polycarboxylate (1) 1.0 Triclosan 0.1 Purified water Balance 100.0% by weight

Example 2 Toothpaste Calcium hydrogen phosphate dihydrate 45% by weight 60% Sorbitol solution 25 Propylene glycol 5.0 Sodium lauryl sulfate 1.5 Carboxymethyl cellulose 0.7 Carrageenan 0.5 Sodium saccharin 0.2 Perfume 1.0 Sodium benzoate 0.2 Sodium monofluorophosphate 0.78 Potassium polycarboxylate (2) 2.0 Triclosan 0.05 Purified water Balance 100.0% by weight

Example 3 Toothpaste Silicic anhydride 25% by weight Glycerin 30 60% Sorbite solution 25 Polyethylene glycol 400 5.0 Sodium lauryl sulfate 1.5 Sodium carboxymethyl cellulose 1.0 Sodium saccharin 0.1 Perfume 1.0 Flu Sodium chloride 0.22 Magnesium sulfate heptahydrate 1.56 Sodium polycarboxylate (7) 5.0 Thymol 0.2 Purified water Balance 100.0% by weight

Example 4 Toothpaste Aluminum hydroxide 45% by weight 60% Sorbite solution 25 Propylene glycol 5.0 Sodium lauryl sulfate 1.5 Hydroxyethylcellulose 1.5 Saccharin sodium 0.1 Fragrance 1.0 Sodium monofluorophosphate 0.78 Hinokitiol 0.1 Sodium polycarboxylate (4) 5.0 Purified water Balance 100.0% by weight

Example 5 Liquid Toothpaste Silicic Anhydride 15% by Weight Glycerin 35 60% Sorbite Liquid 35 Propylene Glycol 5.0 Sodium Lauryl Sulfate 1.5 Xanthan Gum 0.2 Sodium Polyacrylate 0.2 Sodium Saccharin 0.1 Fragrance 1.0 Sodium fluoride 0.22 Triclosan 0.1 Magnesium chloride hexahydrate 0.05 Potassium polycarboxylate (3) 1.0 Purified water Balance 100.0% by weight

Example 6 Toothpaste Calcium hydrogen phosphate dihydrate 45% by weight Glycerin 20 Propylene glycol 5.0 Sodium lauryl sulfate 1.0 N-Lauroyl sarcosine sodium 0.5 Carrageenan 0.5 Saccharin sodium 0.1 Perfume 1.0 Paraben 0.1 Tranexamic acid 0.1 Bisabolol 0.2 Sodium polycarboxylate (6) 1.0 Purified water Balance 100.0% by weight

Example 7 Mouthwash Ethanol 20% by weight Sodium saccharin 0.05 Fragrance 1.0 Polyoxyethylene hydrogenated castor oil (60EO) 1.5 Potassium polycarboxylate (6) 0.5 Triclosan 0.05 Citric acid Sodium acid Suitable amount of purified water Balance 100.0% by weight

Example 8 Mouthwash Ethanol 30% by weight Sodium diphosphate phosphate 0.8 Potassium monophosphate 0.1 Saccharin sodium 0.05 Fragrance 0.5 Glycyrrhizinate 0.1 Magnesium chloride hexahydrate Product 0.13 Sodium polycarboxylate (1) 0.2 Triclosan 0.05 Purified water Balance 100.0% by weight

Example 9 Chewing gum Gum base 40% by weight Calcium carbonate 2.0 Water candy 15.0 Sugar 35.0 Fragrance 0.5 Magnesium citrate nonahydrate 2.55 Sodium polycarboxylate (1) 0 Sorbic acid 0.2 Purified water Balance 100.0% by weight

Example 10 Gargle Tablets Sodium Bicarbonate 55% by Weight Sodium Diphosphate Phosphate 10.0 Polyethylene Glycol 400 3.0 Fragrance 1.0 Oleic Acid 0.1 Chlorhexidine Hydrochloride 0.05 Citric Acid 17.0 Hinokitiol 0.1 Magnesium sulfate heptahydrate 3.1 Sodium polycarboxylate (5) 5.0 Purified water Balance 100.0% by weight

Example 11 Denture Cleaning Paste Silica Anhydride 3.0% by Weight Thickening Silica 10.0 Polyethylene Glycol 400 5.0 Glycerin 35 60% Sorbite Solution 30 Sodium Lauryl Sulfate 2.0 Sodium Carboxymethyl Cellulose 1. 5 Perfume 1.0 Thymol 0.5 Zinc chloride 0.42 Ammonium polycarboxylate (7) 5.0 Purified water Balance 100.0% by weight

[Brief description of the drawings]

FIG. 1 is a graph showing a change over time of a sodium hydroxide solution added to maintain a constant pH of a solution when hydroxyapatite is formed from calcium ions and phosphate ions.

Claims (1)

[Claims] 1. An oral composition comprising, as essential components, a polycarboxylic acid or a salt thereof derived from a polysaccharide having anhydrous glucose as a constitutional unit, and a non-cationic antibacterial substance.