JPH11147820A - Keratin ameliorant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a keratin ameliorant sheet capable of efficiently ameliorating keratin without trouble of wearing gloves and socks, separation of the keratin ameliorant and further contamination of bedclothes with keeping the state that the keratin ameliorant is directly applied to solidified keratin parts and rough parts on elbows and knees. SOLUTION: This keratin ameliarant sheet 1 is composed of a sheet 2 made of polyesteric nonwoven fibers on which the layer 3 of an adhesive including the keratin ameliorant consisting of humestante such as urea and the like is installed. When necessary, a separator 4 is additionally installed on the layer 3 of the adhesive.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a keratin-reducing agent in the form of a sheet for softening the keratinous part of the epidermis of hardened skin, such as elbows, knees, heels and fingertips, and keeping beautiful skin, that is, a keratin-reducing sheet. .

[0002]

2. Description of the Related Art The skin is an important organ because it has a role of covering the whole body and protecting the living body from various stimuli, obstacles or dryness from the outside. The beauty aspect of preserving is also an important concern for both young and old.

[0003] The skin is roughly divided into three layers: epidermis, dermis, and subcutaneous tissue from the top (from the outside). This epidermis is a stacked layer having a thickness of about 0.1 to 0.3 mm, and is divided into a stratum corneum, a granular layer, a spiny layer, and a basal layer from above. The most important physiological function of the epidermis is to form the outer skin, the stratum corneum, which serves as a barrier against various external stimuli such as drying, ultraviolet rays and other physical and chemical stimuli.

[0004] In the epidermis, the basal cells in the basal layer, the spiny cells in the spinous layer, and the granule cells in the granular layer sequentially move to the surface layer while changing to morphologically characteristic cells. Become keratinocytes, and this process of epidermal cell differentiation is called "keratinization". Keratinocytes continue to be made one after another,
The outermost layer of the stratum corneum is detached as debris, so that a constant thickness is usually maintained.

[0005] When a foreign substance enters or the stratum corneum is destroyed, it reacts sensitively, the division of the basal cells becomes active, the keratinization speed is increased, and the foreign substance is eliminated or repaired. However, when these chemical and physical stimuli are repeatedly applied to the skin, the stratum corneum becomes thick and hard. Further, the balance of restoration is lost, and a so-called rough skin state is exhibited. Conventionally, elbows, knees, heels, which tend to cause thickening of the stratum corneum and rough skin,
In order to improve keratinous parts such as fingertips, a cream-like drug containing an effective ingredient for improving rough skin and keratin such as urea ointment and moisturizing cream has been directly applied to a necessary site and used.

[0006]

However, such a creamy drug, that is, a so-called cream, is merely applied to a necessary portion on the skin and placed on the skin, and is applied to the skin according to the viscosity and applicability of the cream itself. No further effort is made to stay on the skin anymore.

It is well known that it takes a certain amount of time to improve the keratin, and it is desired that the effective component for the keratin improvement stays on the skin for a long time, but is merely applied as a cream. Therefore, the applied cream provided on the elbow or knee or the like comes into contact with the outside due to the movement of the elbow or knee or the like, and the applied cream is often removed. Also, creams are often applied at bedtime for customary reasons or for practical reasons that the elbows, knees, etc. to which the cream is applied are rarely moved.

However, at bedtime, the applied part touches the bedding,
Or, rubbing may occur and the applied cream may also come off. Then, in that case, the time for the cream to act on the skin is short, and longer days are required for keratin improvement. At the same time, the bedding becomes soiled with cream, which is undesirable. That the applied cream comes off at bedtime,
In addition, in order to prevent soiling of the bedding, it is common practice to go to bed with gloves or socks covering the application section.

However, the use of protective equipment such as gloves and socks is originally cumbersome, and it can make a person sleepy at bedtime, which often makes the wearer feel inconvenience. Therefore, an object of the present invention is to solve the above problems. And, while maintaining the state of direct application of the active ingredient to hardened keratinous parts and rough parts such as elbows and knees, it is troublesome to wear gloves and socks, the active ingredient is removed and lost, and bedding An object of the present invention is to provide a keratin-improving sheet capable of efficiently improving keratin without soiling.

[0010]

According to the first aspect of the present invention,
It is characterized in that an adhesive layer containing a keratin improving agent is provided on a sheet. According to a second aspect of the present invention, in the keratin improvement sheet according to the first aspect, the sheet is made of at least one member selected from the group consisting of resin, paper, cloth, and nonwoven fabric.

According to a third aspect of the present invention, in the keratin improving sheet according to any one of the first and second aspects, the keratin improving agent contains at least one of a therapeutic agent for keratotic skin disease and a moisturizing agent. It is characterized by the following. According to the first aspect of the present invention, the application of the keratin-improving agent to hardened keratin parts such as elbows and knees and rough parts is performed by direct application using an adhesive provided on a sheet. Becomes possible.

Further, in the state of direct application, an adhesive containing a keratin improving agent is provided thereon, and a sheet supporting the adhesive covers and protects the adhesive applied to the skin. Becomes possible. Therefore, it is possible to prevent the pressure-sensitive adhesive containing the keratin-improving agent from being rubbed by coming into contact with the outside or the like and being removed from the skin which needs to be adhered.

[0013] Therefore, it can be directly attached to hardened keratinous parts such as elbows and knees or rough parts, does not bother wearing gloves and socks, protects the application state of the keratin improving agent, and allows the keratin improving agent to be applied to the skin. It is possible to efficiently improve the keratin without being lost from the top, and to provide a keratin improvement sheet that does not stain bedding. According to the second aspect of the present invention, it is easy to provide a pressure-sensitive adhesive containing a keratin improving agent on the sheet, and the sheet is sufficiently supported and prevented from being removed from its moderate strength. It is possible.

Further, the sheet has flexibility and can be deformed, and can be cut into an arbitrary shape by cutting it with an adhesive. The direct application of the pressure-sensitive adhesive containing the improving agent can be effectively performed under optimal conditions. Therefore, it can be directly and optimally applied to hardened keratinous or rough parts such as elbows and knees, without the need to wear gloves and socks, effectively protecting the application of keratinizing agents, and improving keratinization. It is possible to provide a keratin-improving sheet that can efficiently improve keratin without losing the medicine from the skin and losing it, and that does not stain bedding.

According to the third aspect of the present invention, the pressure-sensitive adhesive can contain a therapeutic agent for keratotic skin disease and / or a moisturizing agent, and treats keratotic skin disease and efficiently reduces rough skin due to drying. It is possible to treat and effectively improve the keratin. Therefore, it can be directly applied to hardened or keratinous parts such as elbows and knees, so that gloves and socks do not have to be worn, protecting the applied state of the keratin improving agent and losing the keratin improving agent from the skin. It is possible to provide a keratin-improving sheet which can be efficiently treated by treating keratinized skin diseases and moisturizing the skin without losing the keratinous skin, and without soiling the bedding.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION The inventors of the present invention have conducted intensive studies and studies to solve the above-mentioned problems. As a result, a keratin-improving agent is mixed with an adhesive, and the sheet is keratinized and adhered to a hardened skin site. To improve keratin,
The present invention has been completed. The sheet applied to the keratin improvement sheet according to the present invention has a thickness of 0.01 mm to 0.10 m.
An m-thick resin sheet can be used. The resin sheet having such a thickness has high flexibility, is easily deformed together with the provided adhesive, and is sufficiently adapted to the shape of the skin to be stuck, so that the application of the keratin improving agent to the skin can be efficiently secured. .

More specifically, a sheet having the above thickness made of urethane, polyethylene, polypropylene, or polyethylene terephthalate can be used. At this time, it is preferable that an appropriate selection be made in consideration of properties such as strength against deformation and moisture resistance of each resin, price, and the like. still,
This resin sheet may be configured by using a plurality of the resin layers and laminating them. In this case, a desired resin sheet can be formed in consideration of the strength, humidity resistance, and cost of each resin against deformation.

Further, the keratin-improving sheet according to the present invention comprises:
It is also possible to increase the strength and to maintain the adhesion state of the adhesive to the skin while supporting and restricting the movement of the fingertip or the like. It is desirable that the thickness be further thicker than the above range to such an extent that the movement of the application part can be restricted. Further, as the sheet applied to the present invention, a nonwoven fabric made of natural fibers, synthetic fibers or a mixture thereof at 10 to 100 g / m ² can be used. Such a nonwoven fabric sheet has high flexibility, is easily deformed together with the provided pressure-sensitive adhesive, sufficiently conforms to the shape of the skin to be affixed, and can efficiently apply the keratin improving agent to the skin.

Also, a cloth sheet made of natural fibers, synthetic fibers or a mixture thereof, which does not contain a nonwoven fabric, has high flexibility, is easily deformed together with the provided adhesive, and has a shape of the skin to be applied. It can be used because it is sufficiently compatible with keratin-improving agents and can efficiently apply the keratin improving agent to the skin. Further, the paper sheet is also thick enough to ensure sufficient flexibility, and can be applied to the keratin-improving sheet according to the present invention. In this case, it is desirable to use the resin after improving the durability by further performing appropriate water resistance treatment or the like.

Further, a metal sheet of aluminum or the like can be applied to the keratin-improving sheet according to the present invention because it has a thickness enough to ensure sufficient flexibility. In this case, if necessary, it is preferable to use the antioxidant after improving the durability by performing an appropriate antioxidant treatment. Next, as the keratin-improving agent to be mixed with the pressure-sensitive adhesive applied to the keratin-improving sheet according to the present invention, all keratin-improving drugs can be used. Specifically, a therapeutic agent for keratotic dermatosis, which can be used for direct treatment, and a moisturizer for moisturizing the skin to prevent its drying and condition the skin can be used. In addition, keratin exfoliating agents such as sulfur and resorcinol, and agents and substances for the purpose of improving the usability for users such as fragrances can be used.

The therapeutic agent for keratotic skin disease, moisturizing agent, and exfoliating agent may be generally applicable to cosmetics, quasi-drugs, and pharmaceuticals, and there is no particular limitation. It should be noted that the therapeutic agent for keratotic skin disease is not used for direct treatment, but also includes a drug for improving the usability during treatment.

Hereinafter, the agents usable as the therapeutic agent for keratotic dermatosis used in the keratinizing sheet according to the present invention will be specifically described. Usable keratotic skin disease therapeutic agents include anti-inflammatory agents, astringents, fresheners, vitamins, hormones, antihistamines, bactericides or plant extracts, and one or two of them as the following specific substances: These can be mixed and used.

More specifically, an anti-inflammatory agent is used to prevent local irritation to the skin due to irritation from the external environment or a wound, etc., and glycyrrhizic acid derivatives such as β-glycyrrhetinic acid and dipotassium glycyrrhizinate. , Allantoin, ε-aminocaproic acid or hydrocortisone can be used. Astringents tighten the skin,
It is used for conditioning, and zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum sulfate, zinc sulfocarbonate, tannic acid, citric acid or lactic acid can be used.

The cooling agent is for giving the skin a refreshing feeling during treatment, and menthol or camphor can be used. Vitamins are important for maintaining skin physiology and are formulated to prevent various skin conditions due to their deficiency. Specifically, vitamin A containing fatty acid esters such as palmitate and acetate which are effective in drying and keratinization of the epidermis, vitamin B ₆ and nicotinic acid derivatives which are effective in seborrheic dermatitis and have skin cell activating action Vitamin B containing e.g., vitamin D that is effective for eczema and skin dryness, vitamin E that is effective for blood circulation and antioxidant activity, pantothenic acid or dermatitis including calcium pantothenate and ethyl pantothenate ethyl ether that are effective for dermatitis Effective vitamin H can be used.

Hormones are effective in maintaining skin homeostasis and include estrogen, including estradiol or esters thereof, estrone or ethinyl estradiol,
Alternatively, corticosteroids including cortisone or an ester thereof, hydrocortisone or an ester thereof, presonisone or bredronizolone can be used. It is for preventing the action of histamine produced in the skin by irritation, and an antihistamine containing diphenhydramine hydrochloride, chlorpheniramine maleate or a glycyrrhizic acid derivative can be used.

It is for protecting the cleanliness of the skin, and a disinfectant containing zinc pyrithione, trichlorocarbanilide, benzalkonium chloride, benzethonium chloride, chlorhexidine, hinokitiol, phenol, isopropylmethylphenol or triclosan can be used.
It has effects such as an anti-inflammatory effect and a cell activating effect, and plant extracts including carrot extract, licorice extract, psyllium extract, chamomile extract or loquat extract can be used.

Next, agents usable as humectants for use in the keratinizing sheet according to the present invention will be described. Usable humectants include urea, salicylic acid, glycerin, 1,
3-butylene glycol, polyethylene glycol, sorbitol, sodium lactate, sodium 2-pyrrolidone-5-carboxylate, sodium hyaluronate or animal and plant extracts can be used, and the animal and plant extracts include aloe extract, boxweed extract, and spleen extract. Alternatively, a placenta extract is included.

These humectants can be used alone or in combination of two or more. The compounding amount of the humectant is desirably within a range in which the adhesive containing the humectant can exhibit a sufficient adhesive action. A blending amount of 45% by weight is good. Next, the pressure-sensitive adhesive applied to the keratin improvement sheet according to the present invention is generally a so-called haptic such as an acrylic pressure-sensitive adhesive,
An adhesive used for the scratch tape can be used.

Next, regarding the production and use of the keratin-improving sheet according to the present invention, the keratin-improving sheet has a side of 5
It can be manufactured to be a rectangle or square of ~ 50 cm, and the user who uses it can cut and use it in an appropriate shape and size at the time of use to improve keratin, and It is also possible to form in advance a suitable size and shape assuming actual use at the manufacturing stage, such as a scratch tape or a bandage.

Further, in order to protect the pressure-sensitive adhesive layer containing a humectant or the like when not in use during storage or the like so that the pressure-sensitive adhesive layer does not stick to the outside or lose its adhesive strength,
It is also possible to provide a separator layer on the pressure-sensitive adhesive layer. It is desirable that this separator layer can be easily peeled off from the pressure-sensitive adhesive layer at the time of use.

Hereinafter, the present invention will be described in detail with reference to examples.

[0032]

EXAMPLES The composition of the pressure-sensitive adhesive containing a humectant and the like used in the exfoliating sheet of the present invention is shown below. The compounding amount is represented by% by weight based on the whole pressure-sensitive adhesive obtained. Urea 15.0% Glycerin 10.0% Aloe extract 0.1% Sulfur 3.0% Acrylic adhesive 71.9% Next, a method for producing the keratin-improving sheet according to the present example will be described.

Urea (), glycerin (), aloe extract (), and sulfur () are mixed with the commercially available acrylic pressure-sensitive adhesive () according to the above composition. Then, after thoroughly stirring to form a uniform mixture, a polyester nonwoven fabric (40 g / m ² ) is prepared, and it is used as the sheet 2, and the mixture is applied thereon in an amount of 100 g / m ^2. .

In addition, the surface is applied on top of the applied mixture layer.
Stack the paper separator coated with silicone and dry
And remove unnecessary volatile components. Finally, cut to the specified dimensions.
Refuse. FIG. 1 is an embodiment according to the present invention.
It is sectional drawing which shows the structure of a sheet. Implementation according to the present invention
The exfoliating sheet 1 as an example is as shown in FIG.
A sheet 2 of polyester non-woven fabric (40 g / m ^Two)
An adhesive layer containing a keratin improving agent having the above composition
3 and a separator on the adhesive layer 3.
4 are provided. In use, it is shown in FIG.
The separator 4 from the adhesive layer 3
To use.

Next, the produced keratin-improving sheet of the present example was used, and its keratin-improving effect was further tested.
In the test method, 20 panelists were prepared, and the horny portion of the heels of each panelist was peeled off and the separator 4 was attached to the horny portion of the heel every day before going to bed, and the sheet 1 was peeled off the next morning. This was done by examining the number of days required for improvement.

First, regarding its use, the exfoliating sheet 1 according to the present embodiment is deformed in accordance with the shape of the heel of each panelist and is well applied, and the adhesive layer 3 and the exfoliating portion of the heel are applied. It has been found that a close contact state with the substrate can be sufficiently ensured. Next, as a comparative example, a commercially available urea ointment for the purpose of improving keratin was used as a comparative example, and the effect was compared. The comparison with the keratin-improving sheet of the specific example is such that the urea ointment is applied to the keratinous area of the heel of each of the 20 panelists every day according to a conventional method every day before going to bed so that the ointment cannot be removed. The socks were removed, the next morning the socks were removed, and the number of days required for keratin improvement was determined.

The test results are summarized as the average number of days until keratin improvement, the minimum number of days until keratin improvement, and the maximum number of days until keratin improvement in 20 panelists, and the respective data are compared with the keratin improvement sheet of this example and the comparative example. And to confirm its keratin improvement effect. FIG.
It is the table | surface which put together the test result of the keratin improvement effect of the keratin improvement sheet which is an Example concerning this invention.

The average number of keratin-improving days is 3 days for the keratin-improving sheet of this embodiment, and 2 days for the comparative example.
Day 0. The keratin improvement minimum days are 1 day in the case of the keratin improvement sheet of the present embodiment, and 7 in the case of the comparative example.
Day. The maximum number of keratin improvement days is 7 days in the case of the keratin improvement sheet of this example, and 60 days in the case of the comparative example.
Day.

From the data relating to any of the items such as the average number of days of keratin improvement, it was confirmed that the keratin improvement sheet of this example had a higher keratin improvement effect than the commercially available urea ointment of Comparative Example. From the above, the keratin improvement sheet of the present embodiment, while maintaining the state of direct application of the active ingredient to the hardened keratin parts and rough parts such as elbows and knees, and the inconvenience of wearing gloves and socks, It has become clear that the effective ingredients can be efficiently improved without removing the active ingredient and losing the bedding, and without soiling the bedding.

[0040]

According to the first aspect of the present invention, it can be directly attached to hardened keratinous parts such as elbows and knees or rough parts, and there is no need to wear gloves or socks, and application of keratin improving agents is possible. It is possible to provide a keratin improving sheet that protects the condition, can efficiently improve keratin without losing the keratin improving agent from the skin and disappearing, and furthermore does not stain bedding.

According to the second aspect of the invention, the sheet has flexibility and can be deformed, and can be cut into an arbitrary shape together with the adhesive, so that the sheet needs to be stuck. According to the skin shape of the part, it is possible to effectively perform the direct application of the adhesive containing the keratin improving agent under the optimum condition. Therefore, it can be directly and optimally applied to hardened keratinous or rough parts such as elbows and knees, without the need to wear gloves and socks, effectively protecting the application of keratinizing agents, and improving keratinization. It is possible to provide a keratin-improving sheet that can efficiently improve keratin without losing the medicine from the skin and losing it, and that does not stain bedding.

According to the third aspect of the present invention, it can be directly attached to hardened keratinous parts or rough parts such as elbows and knees,
There is no need to wear gloves and socks to protect the applied condition of keratin improving agent, and the keratin improving agent is not lost and lost on the skin. It is possible to provide a keratin improvement sheet that does not stain bedding.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing a structure of a keratin-reducing sheet according to an embodiment of the present invention.

FIG. 2 is a table summarizing test results of a keratin-improving effect of a keratin-improving sheet that is an example according to the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Exfoliating sheet 2 Sheet 3 Adhesive layer 4 Separator

Claims (3)

[Claims] 1. An exfoliating sheet comprising a sheet and an adhesive layer containing an exfoliating agent. 2. The keratin sheet according to claim 1, wherein the sheet is made of at least one member selected from the group consisting of resin, paper, cloth, and non-woven fabric. 3. The keratin improving sheet according to claim 1, wherein the keratin improving agent contains at least one of a therapeutic agent for keratotic skin disease and a moisturizing agent. Improvement sheet.