JPH11142384A - Injection apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an injection apparatus which efficiently and continuously sends various material solutions and solvents when the various or many material solutions are to be dispensed. SOLUTION: The apparatus comprises a plurality of injectors 2. Each injector 2 has in a tube-like cylinder a movable plug, a fixed plug and a free plug positioned between the movable and fixed plugs. A ring recess is set at an inner wall face of the cylinder at a position adjacent to the fixed plug to circulate a liquid from a gap to the free plug. Passage switch valves 4, 5 are also provided to selectively send the liquid to the injectors 2.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a structure of an injection device capable of performing a highly efficient sorting operation.

[0002]

2. Description of the Related Art A method for separating a sample using a liquid chromatograph apparatus is basically intended for analyzing a sample or for separating a specific component. It is based on a similar principle. However, in the case of a device for the purpose of fractionation, since it is necessary to obtain a large amount of sample with high accuracy in a short time, the form of the device is different.

[0003] For example, it is difficult to separate a sample solution (a raw material solution in the case of separation and purification) simply by feeding it into a column. Therefore, it is necessary to sequentially and alternately send a sample solution and a solvent. Therefore, an injector is necessary, but in the conventional injector, the raw material solution and the solvent are sequentially sent out using two types of injectors, or the raw material solution is sent out by one injector, and then the injector is filled with the solvent again, and then again. The equipment had to be sent out, and the equipment was large and complicated, and the work was cumbersome.

The inventor of the present invention has a movable stopper, a stationary stopper, and a floating stopper located between the movable stopper and the stationary stopper in a cylindrical cylinder as injectors for sequentially delivering two different liquids. In addition, a ring-shaped concave portion for allowing liquid to flow from the gap with the migration plug was provided at a position adjacent to the fixed plug (Japanese Utility Model No. 1-4473).
issue). As a result, different solutions can be delivered by one injector without mixing.

[0005]

However, if the above-mentioned injector is employed, the solvent (or the subsequent washing liquid) can be continuously delivered after the raw material solution has been put in and the fixing stopper has been fixed, but the processing is performed by a series of these operations. Only one kind of the raw material solution can be used.If it is intended to cope with many kinds of raw material solutions, remove the fixing plug, return the migration plug, etc. to the predetermined position, and wait until the operation of injecting the raw material solution again is completed. I had to stop the picking work.

[0006]

In view of the above points, the present inventor has finally made the present invention as a result of intensive research, and the feature of the present invention is that the apparatus is constituted by a plurality of injectors. Each of the injectors has a movable stopper, a stationary stopper, and a migration stopper located between the movable cylinder and the stationary stopper in a cylindrical cylinder, and a liquid flows through an inner wall surface of the cylinder from a gap between the injector and the migration stopper. And a ring-shaped concave portion is provided at a position adjacent to the fixing plug, and a flow path switching valve for selectively delivering liquid to the injector is provided.

That is, according to the present invention, a plurality of injectors of a type capable of delivering different solutions without mixing are arranged, and a flow path switching valve for selectively delivering a liquid is provided in each of the injectors, so that time is reduced. This makes it possible to obtain an injection system with almost no permanent loss.

[0008] The "injector" has a flow path parallel to the column, but may include a flow path for a liquid which is not discharged to the column and is discharged as it is. The number of injectors should be two or more, but in reality, about 5 to 15 injectors are the optimal number excellent in handleability and economy.

[0009] The flow path switching valve is a valve for selecting one of the plurality of injectors, and to which injector a solvent or a cleaning liquid is delivered is manually or automatically determined and switched. The specific structure is not particularly limited.

Further, the present invention relates to an injection device, and does not limit the structure of a column at all. However, since it has a plurality of injectors, it is possible to effectively cope with the case where a plurality of columns are arranged.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be further described below with reference to the drawings.

FIG. 1 schematically shows an example of an injection apparatus 1 according to the present invention (hereinafter referred to as the present apparatus 1). In the device 1 of the present invention of this example, ten injectors 2 (each having a sub-number of 20 to 29) are arranged, and a pair of tubes 31 and 32 are installed in each injector 2. , IN-side flow path is formed by a tube 31, and OUT-side flow path is formed by a tube 32.

The tubes 31 coming out of the respective injectors 2 reach the flow path switching valve 4, where they are collected at one place. A solution in which two kinds of solvents are mixed at an appropriate ratio or a cleaning liquid is introduced into the flow path switching valve 4.

Further, in the case of the device 1 of the present invention, ten tubes 32 forming the OUT-side flow path reach the flow path switching valve 5. The flow path switching valve 5 is synchronized with the flow path switching valve 4, and the presence of the flow path switching valve 5 allows the IN-side flow path and the OUT-side flow path to be connected by the same tube and connected to the downstream (column side). Become.

FIG. 2 is a schematic view showing the structure of the injector 2 used in the apparatus 1 of the present invention. As shown in FIG. The stopper 8 has a movable stopper 9 at a lower portion. The size of the recess 7 is such that
When it enters, it is of such a size that the solvent can pass upward through the outside of the migration stopper 8. The movable stopper 9 is provided with a through hole 10 at the center thereof, and the through hole 10 communicates with a tube 31 (not shown). The fixing plug 11 is fixed after introducing the raw material solution A into the injector 2 whose upper part is open to the atmosphere. In the case of the device 1 of the present invention, since ten injectors 2 are provided, continuous dispensing of up to ten types of raw material solutions is possible.

Thereafter, the movable stopper 9 is moved in order to discharge the air in the cylinder 6 and the stationary stopper 11. After the discharge is completed, the movable stopper 9 is not moved, and the solvent B is press-fitted.
Thereby, the stopcock 8 moves. Migratory tap 8
Until the water reaches the concave portion 7, the floating stopper functions not only as a piston but also as a packing to prevent the raw material solution A and the solvent B from being mixed.

When the traveling stopper 8 reaches the recess 7, a gap is formed between the traveling stopper 8 and the inner wall of the cylinder 6. After this stage, the solvent B moves upward and is discharged from the injector 2.

[0018]

As described above, the injection device according to the present invention is a device constituted by a plurality of injectors, each of which comprises a movable stopper and a stationary stopper, and a movable stopper located between them. A stopper is provided in a cylindrical cylinder, and a ring-shaped concave portion is provided on an inner wall surface of the cylinder at a position adjacent to the fixed stopper to allow a liquid to flow from a gap with the migration stopper. Further, the invention is characterized in that the injector is provided with a flow path switching valve for selectively delivering liquid to the injector, and is an extremely advanced invention having the following effects.

Since the raw material solution, the solvent and the like can be sent out without being mixed by one injector, the sorting operation can be performed very efficiently. Even in the case of dispensing a large or large amount of the raw material solution, the liquid can be delivered by changing the injector one after another, so that the dispensing does not stop for removal of the fixing plug or other work. Since the switching of the flow path can be automated, there is no fear of confusing the operation of the operator by having a plurality of injectors.

[Brief description of the drawings]

FIG. 1 is a flowchart schematically showing an injection device according to the present invention.

FIG. 2 is a schematic sectional view showing an example of an injector used for the injection device according to the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Injection apparatus which concerns on this invention 2 Injector 20-29 Injector 31 Tube 32 Tube 4 Flow path switching valve 5 Flow path switching valve 6 Cylinder 7 Concave part 8 Migration plug 9 Movable plug 10 Through hole 11 Fixed plug A Raw material solution B Solvent

Claims (1)

[Claims] 1. An apparatus comprising a plurality of injectors, wherein each injector has a movable stopper, a stationary stopper, and a migration stopper located between them in a cylindrical cylinder. A ring-shaped concave portion is provided on the inner wall surface of the cylinder for allowing liquid to flow from the gap with the migration plug at a position adjacent to the fixed plug, and the liquid is selectively delivered to the injector. An injection device comprising a flow path switching valve for performing the following.