JPH11130669A - Amino acid-based nutrient preparation for preventing/ treating bedsore - Google Patents

Abstract

PROBLEM TO BE SOLVED: To develop and obtain a nutrient composition useful for the systemic therapy or prevention of bedsore. SOLUTION: This amino acid-based nutrient preparation and a related nutrient food each contains the following amino acids in the corresponding proportions: L-arginine 6.0-21.0 mol.%, L-isoleucine 6.0-20.0 mol.%, L-leucine 8.0-25.0 mol.%, L-valine 6.0-19.0 mol.%, L-lysine 1.0-6.0 mol.%, methionine 2.0-8.0 mol.%, L-threonine 4.0-13.0 mol.%, L-histidine 1.0-6.0 mol.%, L-proline 3.0-9.0 mol.%, L-phenylalanine 0.2-1.0 mol.%, L-tryptophan 0.1-1.0 mol.%, and L- glutamine 8.0-27.0 mol.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic agent for pressure ulcer and a food for prevention and treatment of pressure ulcer, which are required in the treatment process of a patient with pressure ulcer, and more specifically to a specific amino acid as an active ingredient. The present invention relates to an amino acid nutrient for pressure ulcer prevention and treatment and an amino acid nutritional food for pressure ulcer prevention and treatment characterized by containing at a ratio of:

[0002]

2. Description of the Related Art Recent advances in medical technology have made it possible to save many lives, while many Abilites have been saved.
It is an undeniable fact that care-requirers with reduced y of Daily Life (ADL daily living ability) have been created. The presence of pressure ulcers (rubbing on the floor) in such care recipients is mentally
This is an extremely heavy physical burden and has a great effect on the continuation of medical treatment.

[0003] Pressure ulcers are conditions in which local blood flow is impaired due to pressure on the skin, and as a result, skin tissue is injured by circulatory failure. In mild cases, it stops at the erosion on the skin surface. In severe cases, skin ulcers form from the subcutaneous tissue to the bones and ligaments, and are extremely intractable. In some cases, bacterial infection can lead to death. For example, elderly people have a high mortality rate due to sepsis or pneumonia, but the primary infection focus is pressure sores. Pressure ulcers can be infected or colonized,
It has a large amount of bacteria in its secretions, which can be a problem in infection control in hospitals.

[0004] Conventionally, treatment of pressure ulcers is roughly classified into 1) change of body position and decompression, 2) disinfection of wound sites, 3) removal of necrotic tissue, 4) promotion of wound healing, 5) protection of wounds, and the like. 4)
Although all treatments except for the promotion of wound healing are effective treatments in suppressing the development of pressure ulcers, they are not directly involved in the healing process of pressure ulcers and are not methods of promoting healing. Regarding the promotion of wound healing in 4), relatively useful therapeutic agents have been developed in recent years. However, since patients suffering from pressure ulcers are extremely malnourished, sufficient therapeutic results can be obtained. I haven't gotten it.

[0005] The healing of pressure ulcers depends on the formation of granulation at the wound site.
Tissue remodeling, such as closure of skin ulcers, is required, but thorough oral nutrition as a systemic therapy is the best method from the standpoint of benign granulation tissue growth. In particular, in order to reconstruct these tissues, it is essential to take in amino acids and proteins sufficiently. Nevertheless, in general, pressure ulcer patients often have difficulty in oral ingestion, so they are often undernourished, and treatment methods for various pressure ulcers have not achieved satisfactory results.

[0006]

In the context of the prior art described in the preceding paragraph, the present invention provides a method for treating various pressure ulcers by improving the conventional nutritional intake, and improving the pressure ulcer treatment. The purpose is to prevent.

[0007]

Means for Solving the Problems As a result of intensive studies to achieve the object described in the preceding section, the present inventor has found that ingesting a specific amino acid to a pressure ulcer patient at a specific ratio is effective for pressure ulcer healing, and It has been found that ingesting the specific amino acid at the specific ratio to a patient suffering from pressure ulcer may be effective in preventing pressure ulcer, and the present invention has been completed based on such findings.

That is, the present invention relates to an amino acid nutrient for the prevention and treatment of pressure ulcers, which comprises the following amino acids as active ingredients in the following ratio (molar ratio (%)).

L-arginine 6.0-21.0, L-isoleucine 6.0-20.0, L-leucine 8.0-2
5.0, L-valine 6.0-19.0, L-lysine
0-6.0, methionine 2.0-8.0, L-threonine 4.0-13.0, L-histidine 1.0-6.0,
L-proline 3.0-9.0, L-phenylalanine 0.2-1.0, L-tryptophan 0.1-1.0 and L-glutamine 8.0-27.0.

[0010] The present invention also relates to an amino acid nutritional food for preventing and treating pressure ulcers, which comprises the above-mentioned amino acid as an active ingredient in the above-mentioned ratio.

[0011] The present invention focuses on several essential amino acids that most effectively promote protein synthesis in the elderly,
By administering small amounts of these amino acids, it was possible to treat pressure ulcer patients and prevent pressure ulcers, for which conventional nutritional treatments and treatments with drugs could not achieve a sufficient therapeutic effect.

[0012]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.

The specific amino acids referred to in the present invention include L-arginine, L-isoleucine, L-leucine, L-valine, L-lysine, methionine, L-threonine, L-histidine, L-proline and L-phenylalanine. , L-
Tryptophan and L-glutamine. Methionine can be used in either the L-form or the DL-form.
-The body is preferred.

Although each amino acid used in the present invention depends on the administration route, it is preferable that each amino acid is a single product and has high purity. For example, an amino acid having a purity equal to or higher than that specified in the “Food Additive Standard” is used. These amino acids may be in the form of their physiologically acceptable salts. For example, L-lysine hydrochloride, L-histidine hydrochloride monohydrate, etc.

An amino acid mixture obtained by hydrolyzing an edible protein with an acid or an enzyme may be used as a raw material. In this case, the excess or deficiency of each amino acid may be adjusted so as to be adapted to the specified amino acid composition ratio before use.

The amino acid nutrient for the prevention and treatment of pressure ulcer of the present invention can be produced, for example, by uniformly mixing the above-mentioned amino acids in the above-mentioned ratio in a powder state. There is no particular limitation on the specific method. For example, a method of mixing the pulverized amino acids using a rocking mixer can be employed. Alternatively, they can be mixed in a solution state and then dried. These operations are performed at room temperature (25
℃) or lower.

In producing an amino acid nutrient, components other than necessary amino acids can be added as necessary or desired. Examples of these additional components include (a) low-caloric saccharides, such as reduced maltose, reduced lactose, trehalose, oligosaccharides, and (b) substances having an action of masking the bitterness of amino acids having bitterness, for example, packaging. (C) cyclodextrin, a substance capable of functioning
Food flavors, (d) food dyes, such as beta-carotene,
(E) a vitamin mix containing various vitamins, (f) a mineral mix containing various minerals, (g) a low calorific sweetener, for example, "aspartame", (h) an acidulant, Examples include citric anhydride, (i) a molding aid such as a long-chain fatty acid ester, and (nu) an amino acid other than the amino acids constituting the amino acid nutrient of the present invention, such as glycine and L-alanine.

As components added to the amino acid nutrient, saccharides or sweeteners having a normal calorific value, that is, sucrose, glucose, fructose, honey, etc.
This can result in providing excess heat to the eater.
In such a case, it is needless to say that excessive addition should be avoided.

The thus prepared amino acid nutrient for the prevention and treatment of pressure ulcer of the present invention can be distributed as it is, that is, in the form of a powder mixture.

The administration may be oral, enteral,
The drug can be administered through a common administration route such as intravenous administration by infusion, but it can be prepared into an appropriate dosage form depending on the administration route and placed in distribution.

For example, in the case of oral administration, there is no particular limitation as long as it is a form that can be easily accepted without giving the user uncomfortable feeling, and it is acceptable as the amino acid composition itself having the above composition or pharmaceutically acceptable. Mixed with a carrier, activator, diluent and the like, and placed in the form of powder, granules, tablets, capsules, troches, syrups and the like. When actually taking it, swallow as appropriate, dissolve or disperse in drinks such as hot water, milk, juice, etc., drink other amino acids, water-soluble vitamins, acidulants such as citric acid, sweeteners such as sugar, etc. , And adding a suitable flavor to make a drink, and eating together with biscuits, wafers and the like.

There is no particular difficulty in producing the amino acid nutritional food for preventing and treating pressure ulcer of the present invention. In other words, in the manufacture of these foods, such as medical foods, foods for the sick, foods for specified health use, or powdered or liquid foods, the same type of amino acids as those used in the amino acid nutrient for pressure ulcer prevention and treatment described above is used. It can be manufactured by blending in the same ratio. And, needless to say, it can take the same distribution form as medical food and the like.

The dosage of the amino acid nutrient and amino acid nutritional food for the prevention and treatment of pressure ulcer of the present invention, depending on the severity of the pressure ulcer, is twice a day in terms of a mixture of a predetermined ratio of the predetermined amino acid described above. The amount can be 0.5 to 10 g, preferably 1.0 to 5.0 g per time.

[0024]

The present invention will be further described with reference to the following examples.

Example 1 One or more months have passed since the occurrence of a pressure ulcer, and 11 cases of pressure ulcers with poor remission tendencies were selected.
A commercially available enteral nutrient having the amino acid composition shown in the table was administered at 1800 kcal / day for the period shown in Table 2 below (Comparative Example), and about 1200 kcal / day was given for 6 cases.
And the above enteral nutritional supplement is administered, and in addition, 1.4 g of an amino acid mixture of a predetermined composition is added twice daily to the amino acid nutritional supplement for the prevention and treatment of pressure ulcer of the present invention shown in Table 1 twice a day before breakfast and dinner. Was administered for the period shown in Table 3 below.

[0026]

[Table 1]

The amino acid compositions of the amino acid nutrients of the present invention used in the examples were all within the ranges shown in the above table.

The above-mentioned commercially available enteral nutritional supplement is obtained by adding an L-type crystalline amino acid to a nitrogen source, dextrin as a heat source, and an electrolyte, trace elements and vitamins. Is blended. Therefore, little digestion is required, duodenal and jejunal administration is possible, and most components are absorbed in the upper gastrointestinal tract, so that no residue is produced and the amount of defecation is reduced.

No change was made in the treatment method for pressure ulcers and the treatment of the subjects during these administration periods. Photographs were taken before the start of administration and thereafter every two weeks, and the progress was observed and evaluated. The evaluation results (judgments) are also shown in Tables 2 and 3, respectively.

[0030]

[Table 2]

[0031]

[Table 3]

Several amino acid nutrients are already commercially available. However, it can be seen from Tables 2 and 3 that even when the same amino acid is administered, it is more remarkable to administer the prescribed amino acid in the present invention at a prescribed ratio to the present invention than in the case where the same amino acid is not administered. Can be understood to be effective.

From this, it can be understood very easily that the amino acid nutrient for the prevention and treatment of pressure ulcer and the amino acid nutritional food for prevention and treatment of pressure ulcer of the present invention are effective for prevention of pressure ulcer in a sick person.

[0034]

According to the present invention, an amino acid nutrient as an excellent systemic remedy for pressure ulcers or an excellent agent for pressure ulcer prevention can be easily provided.

Claims (2)

[Claims] 1. An amino acid nutrient for the prevention and treatment of pressure sores: L-arginine 6.0-21.
0, L-isoleucine 6.0-20.0, L-leucine 8.0-25.0, L-valine 6.0-19.0, L-
Lysine 1.0-6.0, Methionine 2.0-8.0, L
-Threonine 4.0-13.0, L-histidine 1.0
~ 6.0, L-proline 3.0 ~ 9.0, L-phenylalanine 0.2 ~ 1.0, L-tryptophan 0.1 ~
1.0 and L-glutamine 8.0-27.0. 2. An amino acid nutritional food for preventing and treating pressure ulcers, which comprises the amino acid according to claim 1 as an active ingredient in the ratio described in the same.