JPH11130618A - Production of cosmetic raw material containing active ingredient of crude pyroligneous acid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic raw material containing an active ingredient of a crude pyroligneous acid by removing a biologically toxic substance contained in the crude pyroligneous acid. SOLUTION: A crude pyroligneous acid is mixed with a cosmetic raw material selected from a hydrocarbon, oils and fats, waxes and higher fatty acids under heating to thereby remove formaldehyde, methanol and a strong acid ingredient of a readily skin irritating substance which are biologically toxic substances contained in the pyroligneous acid and make active ingredients in the crude pyroligneous acid migrate into the cosmetic raw material. A contact treatment with an aqueous solution of an acidic salt, as necessary, is further performed to provide a safer cosmetic raw material. The resultant raw material can be utilized in a cleaning, a hair, a foundation, a makeup, a fragrance, a suntan, an antisuntan, a nail, an eyeliner, a lipstick, an oral cavity and a bathing cosmetics.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics containing active ingredients such as flavanols, phenols and the like, which removes biologically harmful components present in a crude wood vinegar solution (for washing, hair, foundation, makeup, fragrance). Tanning / sunscreening, nails, eyeliners, lips, oral cavity, bathing).

[0002]

2. Description of the Related Art The crude wood vinegar used in the present invention is an aqueous solution produced by cooling smoke generated when carbonizing trees and bark, and its chemical composition varies slightly depending on the type of raw wood to be carbonized. However, typical ones are methanol,
Acetone, formaldehyde, acetoin, 2-methyl-4-oxo-pentan-2-ol, 3-octyl-
Propionate, 4-methylguaiacol, furfural, hexane-2,5-olide, tetrahydrofurfuryl alcohol, o-cresol, p-cresol, m
-Cresol, propionic acid, 5-methylfurfural, cyclothene, 3-hydroxy-2-methyl-4-pyrone, guaiacol, 5-hydroxymethyl-2-furfural, 4-acetyl-2-methoxyphenol,
-Allyl-2,6-dimethoxyphenol, acetic acid and the like. Since this crude wood vinegar solution contains methanol and formaldehyde as biologically harmful components as shown in the above chemical components, it cannot be used as cosmetics, foods and pharmaceuticals unless these harmful components are removed.

Conventionally, various researches and developments using wood vinegar have been made. However, there is no method for removing an active ingredient such as phenol and removing a harmful component such as methanol and formaldehyde. At present, wood vinegar is not commercially available as a product approved by the Ministry of Health and Welfare.

[0004] Recently, cosmetics and soaps using wood vinegar have been marketed unofficially (those not licensed to manufacture and sell by the Ministry of Health and Welfare). However, cosmetic materials produced by a normal manufacturing method include formaldehyde. However, it only contains the wood vinegar containing methanol.

[0005]

It is a well-known fact that wood vinegar contains tannins (phenol components, etc.) that increase skin damage and moisturize since ancient times, but at the same time, formaldehyde, a biologically harmful component, , Methanol is several hundred p
pm, which has been a major obstacle to using it as cosmetics.

[0006] The crude wood vinegar also contains tar and carcinogenic substance such as ben- pyrene. According to the research and development of wood vinegar so far, it has been found that the removal, deodorization, and decolorization of these tar and bench-pyrene are considered. There are many.

[0007] Wood vinegar also contains tens of percent of a strong acid substance such as acetic acid, which causes a burning sensation when the wood vinegar is applied to the skin.

[0008] The present invention is to provide a "body friendly" wood vinegar liquid cosmetic product raw material containing an active ingredient, which removes biologically harmful substances contained in the wood vinegar liquid.

[0009]

SUMMARY OF THE INVENTION According to the present invention, crude wood vinegar is mixed with one or more cosmetic raw materials selected from the group consisting of hydrocarbons, oils and fats, waxes and higher fatty acids while heating. Containing the crude wood vinegar liquid as an active ingredient, wherein the active ingredient in the wood vinegar liquid is transferred to the cosmetic raw material phase and the other ingredients are transferred to the aqueous phase, and then the cosmetic raw material phase and the aqueous phase are separated. This is a method for producing cosmetic raw materials.

In the above-mentioned present invention, it is preferable that after separating the cosmetic raw material phase and the aqueous phase, the cosmetic raw material phase and the aqueous phase are further brought into contact with an aqueous solution of an acidic salt under heating to thereby separate them. Also, a weakly acidic or neutral aqueous solution containing a monohydrogen salt (hereinafter simply referred to as an aqueous monohydrogen salt solution) is selected from the group consisting of sodium hydrogen sulfite, sodium hydrogen carbonate and sodium phosphite. Is preferred. The weak acidity of the aqueous monohydrogen salt solution used is generally in the range of pH 4.5 to 11, preferably 7 to 8.

In the above-mentioned cosmetic raw materials, the hydrocarbons are selected from the group consisting of liquid paraffin, paraffin, ceresin, microcrostalin wax, petrolatum and squalane, and the fats and oils are selected from the group consisting of olive oil, camellia oil, macadamina and castor oil, waxes and the like. Is Carnaubarou,
Preferably, the higher fatty acid is selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid and isostearic acid, from the group consisting of candelilla wax, lanolin, beeswax and jojoba oil.

The present invention also provides a cosmetic characterized by containing the cosmetic raw material obtained by the above-mentioned production method in the range of 0.1 to 50% by weight. Anti-crack creams, sun creams and burnishing creams.

The present invention also provides a non-pharmaceutical antibacterial agent characterized by containing an active ingredient of a crude wood vinegar solution obtained by the above-mentioned production method.・ For mucosal Staphylococcus aureus MRSA infection, superficial skin ・ for tinea mucosa, and superficial skin
For mucosal Pseudomonas aeruginosa infections.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION The crude wood vinegar used in the production of the cosmetic raw material of the present invention is a dry distillate obtained in the process of carbonizing trees and bark. Available. Such a wood vinegar solution (hereinafter referred to as crude wood vinegar solution) usually contains the above-described chemical components,
Generally, the total amount of solid components and volatile components is 2
This is an aqueous solution containing about 0% by weight of a chemical component.

In the present invention, the mixing ratio of the hydrocarbons, oils, waxes and higher fatty acids, which are the raw materials for cosmetics, to the crude wood vinegar is 5 to 100 parts by weight of the cosmetic raw materials.
It is in the range of 30 parts by weight, preferably 5 to 15 parts by weight.
When the amount of the crude wood vinegar used is less than 5 parts by weight, the transfer of undesired substances from the cosmetic raw materials to the aqueous phase is not sufficient, and problems in separation of the cosmetic raw material phase from the aqueous phase are likely to occur. On the other hand, if it exceeds 30 parts by weight, the scale of the apparatus increases, which is not preferable.

The heating conditions at the time of mixing the cosmetic raw material and the crude wood vinegar liquid vary greatly depending on the cosmetic raw material used, but are usually in the range of 40 to 90 ° C., preferably 65 to 85 ° C. If the temperature condition during mixing is less than 40 ° C,
The viscosity of the mixed solution is too high and uniform mixing is insufficient, so that the active ingredient in the crude wood vinegar is not sufficiently transferred to the cosmetic raw material phase, and the undesirable components are not sufficiently transferred to the aqueous phase. If the temperature exceeds 90 ° C., additional equipment for the mixing device is required.

After the active ingredient in the wood vinegar solution is transferred to the cosmetic raw material phase and the other ingredients are transferred to the aqueous phase, the two phases are separated by cooling and standing. Usually, a cooling temperature of about 25-40 ° is sufficient.

The mixing time when the above-mentioned cosmetic raw material and the crude wood vinegar are mixed and the time required for separating the cosmetic raw material phase and the aqueous phase differ depending on the cosmetic raw material to be used. About one hour is sufficient, and the latter is usually sufficient for about one hour.

In the present invention, the cosmetic raw material phase separated from the aqueous phase is brought into contact with a weakly acidic or neutral aqueous solution containing a monohydrogen salt to more completely remove undesirable components such as itching components. be able to. Preferred weakly acidic or neutral aqueous solutions containing monohydrogen salts include Na, K, and the like among alkali metals and / or alkaline earth metals.
Monohydrogen salts which are Ca, in particular, sodium hydrogen sulfite, sodium hydrogen phosphite, calcium hydrogen sulfite, sodium hydrogen carbonate and the like can be mentioned. In this case, the lower limit of the weak acidity is pH 4.5, preferably pH 7 to 8. When the pH in this case is less than 4.5, the removal of the strongly acidic substance in the crude wood vinegar solution tends to be insufficient.

The concentration of the aqueous solution of monohydrogen salt is usually in the range of 2 to 10% by weight, preferably 3 to 7% by weight. Parts by weight. The conditions for contacting the cosmetic raw material with the aqueous monohydrogen salt solution can be substantially the same as the conditions for contacting with the crude wood vinegar solution. That is, the contact temperature is 40 to 100 ° C, preferably 80 to 100 ° C, and the contact time is almost the same. In this way, components such as acetic acid contained in the cosmetic raw materials are removed.

According to the method for producing a cosmetic raw material of the present invention, at least 70% or more of the active ingredient in the crude wood vinegar solution can be transferred into the cosmetic raw material. In order to increase the concentration of the active ingredient in the cosmetic raw material, the contact between the cosmetic raw material and a new crude wood vinegar solution is repeated, and in order to remove undesirable impurities in the cosmetic raw material, an aqueous solution of monohydrogen salt is used. It is needless to say that it is possible to repeat the contact with.

The content of the active ingredient in the crude wood vinegar solution in the cosmetic raw material thus obtained is 100% by weight of the cosmetic raw material.
The content is in the range of 0.1 to 50% by weight, preferably 1 to 20% by weight, and can be changed as appropriate according to the purpose of use of the above-mentioned cosmetics, for example, for washing, for hair, etc., to obtain specific cosmetics.

At this time, it is also possible to mix other active ingredients according to the purpose of use. For example, in order to prevent cracking of the katato and to repair damage to the skin due thereto, a crude wood vinegar solution is used. White petrolatum containing an active ingredient in a crude wood vinegar solution obtained by contact separation of white petrolatum may be used as it is, but for example, in order to increase softness, an appropriate amount of squalane or jojoba oil depending on preference , Glycerin. In this case, it is also possible to add a surfactant in order to improve the mixing of the white vaseline and other compounding agents.

[0024]

The present invention will be further described below with reference to examples.
At the same time, the usefulness of the cosmetic obtained by the production method of the present invention will be described.

Example 1 In the case of manufacturing as cosmetics for preventing cracking of KAGATO and for repairing cracked skin: Driftwood vinegar of Kotozawa, Fukushima Prefecture was used as the crude vinegar. This driftwood vinegar was obtained by carbonizing driftwood in a usual manner using a fushiki kiln and contains the harmful substances shown in Table 1.

500 g of white petrolatum at 80 to 100 ° C.
Dissolve while heating. 25 ml of the above crude wood vinegar solution (total amount of volatiles and solids is 0.6
% By weight) and stirred for about 40 minutes while heating to 80 to 100 ° C. 30% mixture of white petrolatum and crude wood vinegar
C. and left for 1 hour, then discard the crude wood vinegar liquid layer.
Next, the remaining white petrolatum was heated to 80 to 100 ° C. and melted.
And stirred for about 30 minutes while heating to 80 to 100 ° C. At this time, the pH of the aqueous solution was 7.2. This was cooled in the same manner as described above, and the 40% aqueous sodium bisulfite solution was discarded.
490 g of a cosmetic raw material with a weight percentage of 490 g were obtained.

Table 1 shows the status of removal of harmful substances from the cosmetic raw materials.

[0028]

[Table 1] *) The concentration in white petrolatum after heating and stirring the crude wood vinegar liquid and white petrolatum. **) Concentration in white petrolatum after washing white petrolatum with 40% aqueous sodium bisulfite solution.

Example 2 When manufactured as an essence for preventing sunburn and sunburn:
Cosmetic raw materials were produced in substantially the same manner as in Example 1, except that olive oil was used in place of the white vaseline of Example 1. In addition,
In this case, the mixing temperature and the contact temperature with the aqueous sodium bisulfite solution were in the temperature range of 70 to 90 ° C. Table 2 shows the concentration of harmful substances in the obtained cosmetic raw materials.

Example 3 When preparing as a cream for enhancing skin moisturization and flexibility: Beeswax is used in place of white petrolatum in Example 1, and sodium hydrogen phosphite is used in place of sodium hydrogen sulfite. Cosmetic raw materials were manufactured in substantially the same manner as in Example 1. In this case, the mixing temperature and the contact temperature with the aqueous solution of sodium hydrogen phosphite were in the temperature range of 80 to 100 ° C. Table 2 shows the concentration of harmful substances in the obtained cosmetic raw materials.

Example 4 In the case of manufacturing for use as a burnishing cream: Example 1
Was carried out as follows using stearic acid in place of white petrolatum. Mix stearic acid and crude wood vinegar solution dissolved in diethyl ether. After standing at room temperature, discard the aqueous phase.
Again, an aqueous sodium hydrogen sulfite solution was added to the diethyl ether phase and mixed. After standing at room temperature, the aqueous phase was discarded, and the diethyl ether was evaporated to dryness to produce a cosmetic raw material. In this case, the mixing temperature and the contact temperature with the aqueous sodium bisulfite solution were in the temperature range of 25 to 40 ° C. Table 2 shows the concentration of harmful substances in the obtained cosmetic raw materials.

[0032]

[Table 2] Application Reference Example 1 Ultraviolet rays in a wide range of 250 to 400 nm reach the ground. As harmful effects of this ultraviolet ray, erythema of the skin, sunburn, blackening, aging of the skin and the like are known. Dilute the crude wood vinegar with ethanol, wavelength 200-400nm
FIG. 1 shows the results obtained by measuring the absorbance of the crude wood vinegar and investigating the ultraviolet absorption ability of the crude wood vinegar solution. Wavelength 270-280 in crude wood vinegar
Contains a component exhibiting the maximum absorbance at nm, this substance has the ability to absorb UV-B ultraviolet light, and is identified as a phenolic substance from the characteristics of the absorption curve using a standard substance. .

In order to make the raw materials for cosmetic preparations containing the active ingredient of the crude wood vinegar more broadly capable of absorbing ultraviolet light, an ultraviolet absorber having a maximum absorbance at 320 to 380 nm, such as balsole A, may be added. .

Application Reference Example 2 In the production of cosmetics for preventing superficial skin / mucosal infections and repairing skin damage caused by infectious diseases, Candida albicans, yellow which causes superficial skin / mucosal infections Staphylococci, MRSA (mesitylin-resistant Staphylococcus aureus),
The antibacterial activity against Pseudomonas aeruginosa and Trichophyton menagrophytes was examined, and the results are shown in Table 3. Crude vinegar is 0.39% against Staphylococcus aureus, 1.56% against Pseudomonas aeruginosa, and 6.25 against Candida albicans.
% And 0.049% or more against Trichophyton, respectively.

[0035]

[Table 3] Note. n is a dilution factor, for example, n = 8 is 1/2 ⁸ , that is, 1/256.

From the above results, when preparing an antibacterial agent cream for each pathogenic bacterium, it is necessary to adjust the amount of the crude wood vinegar added to white petrolatum.

For example, in the preparation of an antibacterial agent cream for Staphylococcus aureus, 0.4 g of crude wood vinegar solution was added to 100 g of white petrolatum, and the same preparation as in Example 1 was carried out. In the production of cream, 1.6 ml which is 4 times the amount for Staphylococcus aureus will be used.

APPLICATION REFERENCE EXAMPLE 3 The crude wood vinegar used in the present invention was used to measure the elimination effect of hydroxy (.OH) radical generated by Fenton's reagent and superoxy radical generated by hypoxanthine-xanthine oxidase system. JEOL electron spin resonance spectrometer (ESR; JE)
S, FILXG) and the results are shown in FIG. The crude wood vinegar solution showed an elimination rate of 45.4% for hydroxy radicals and 72.4% for superoxy radicals in a 100-fold diluted solution (1% solution).

This result has the effect of eliminating free radicals that promote aging of various cells.

This result has the effect of eliminating free radicals that promote aging of various cells.

Application Example 1 A skin irritation test was carried out to confirm the safety of white petrolatum containing the active ingredient of the crude wood vinegar solution prepared in Example 1. The subjects were 42 men and 56 women, and the target ages were 2 to 76 years for men and 4 to 72 years for women. The purpose of the study was explained to the test subject or their parents in advance, and the test was performed on the test subject whose consent was obtained. The test site was prepared by applying a test sample to a sterile gauze folded in three on the left and right upper backs, and fixed with sagittal tape from above. After fixing, 2
At the 4th hour, the gauze on the upper back was removed and the erythema on the test site was
Changes in the skin such as edema were visually observed.
As a test sample of the crude wood vinegar, a crude wood vinegar diluted with physiological saline to a concentration of 10% was used. No change in skin symptoms such as erythema or edema was observed in all 98 patients. No. which is a part of the result. 19 to 90 are omitted from Table 4
It was shown to.

[0042]

[Table 4] Patch test execution method: The test substance is 1.5 cm in diameter on the upper back, covered with sterile gauze (2.0 × 2.0 cm), and fixed with sagittal tape.

Judgment: The tape was peeled off 24 hours after application of the test substance, and the skin reaction was observed. 1): Existence of erythema rash [-: no erythema +: erythema] 2): Existence of edema [(-): no edema (+): edema] Application Example 2 Crude vinegar is used for various pathogenic microorganisms As it has antibacterial activity, Trichophyton mentagrophy
39 males with tinea pedis, diagnosed according to tes,
For 6 women, white petrolatum containing the active ingredient of the crude wood vinegar solution prepared in Example 1 was applied to the affected area twice a day (morning and evening) for 2 weeks. The effect was judged by visual observation at the second week. No worsening of skin symptoms was observed in both men and women, and the skin symptoms due to Trichophyton dermatophytes in all 45 cases were completely cured by the raw material (white petrolatum) containing the active ingredient of crude wood vinegar liquid.

[0044]

[Table 5]

[0045]

The cosmetic raw material produced by the production method of the present invention contains the active ingredient in the crude wood vinegar solution effectively and does not contain harmful components as other components. For, hair, foundation, makeup,
Aroma, sunburn / sunscreen, nails, eyeliner, lips,
It is expected that we will be able to provide safe products not only in the fields of oral cavity and bathing) but also as prevention of superficial skin and mucosal infections caused by various pathogenic microorganisms (quasi-drugs) based on our research results. .

[Brief description of the drawings]

FIG. 1 is an example of an absorption spectrum of a crude wood vinegar liquid according to a manufacturing facility.

FIG. 2 is an example of a diagram showing a dilution ratio of a driftwood vinegar and a radical scavenging effect.

Claims (15)

[Claims] 1. The active ingredient in a wood vinegar solution, wherein the crude wood vinegar solution is mixed with one or more cosmetic ingredients selected from the group consisting of hydrocarbons, oils and fats, waxes and higher fatty acids while heating. A method for producing a cosmetic raw material containing an active ingredient of a crude wood vinegar solution, wherein the active ingredient is transferred to a cosmetic raw material phase and the other components are transferred to an aqueous phase, and then the cosmetic raw material phase and the aqueous phase are separated. 2. A cosmetic raw material comprising separating a cosmetic raw material phase and an aqueous phase, and further contacting the aqueous phase with a weakly acidic or neutral aqueous solution containing a monohydrogen salt under heating to separate the aqueous phase. Manufacturing method. 3. A cosmetic raw material characterized in that the weakly acidic or neutral aqueous solution containing a monohydrogen salt is selected from the group consisting of sodium hydrogen sulfite, sodium hydrogen carbonate and sodium hydrogen phosphite. Production method. 4. The production of a cosmetic raw material according to claim 1, wherein the hydrocarbon is selected from the group consisting of liquid paraffin, paraffin, ceresin, microclostalin wax, petrolatum, and squalane. Method. 5. The method for producing a cosmetic raw material according to claim 1, wherein the fat or oil is selected from the group consisting of olive oil, camellia oil, macadamina, and castor oil. 6. The method according to claim 1, wherein the wax is selected from the group consisting of carnauba wax, candelilla wax, lanolin, beeswax and jojoba oil. 7. The method for producing a cosmetic raw material according to claim 1, wherein the higher fatty acid is selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid and isostearic acid. . 8. A cosmetic product comprising the cosmetic raw material obtained by the production method according to claim 1 in a range of 0.1 to 50% by weight. 9. The cosmetic according to claim 8, which is a cream for preventing cracking of heels. 10. A sunscreen cream.
Cosmetics according to. 11. A burnishing cream.
Cosmetics according to. 12. An antibacterial agent for external use, comprising an active ingredient of a crude wood vinegar solution obtained by the production method according to any one of claims 1 to 7. 13. Superficial skin and mucosa S. aureus MR
The antimicrobial agent for external use according to claim 12, which is used for SA infection. 14. The antimicrobial agent for external use according to claim 12, which is used for superficial skin and mucosal tinea. 15. The antimicrobial agent for external use according to claim 12, which is used for superficial skin and mucosal Pseudomonas aeruginosa infections.