JPH1112138A - Composition for hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a composition for hair capable of safely and effectively controlling the shape of the hair without causing damage to the hair by using a specific new peptide in combination with a reducing agent. SOLUTION: This composition contains at least one kind of oligopeptide including two or more residues of cysteine and three or more residues of an amino acid consisting of the same kind amino acid without the cysteine, and a reducing agent formulated therewith. The same kind amino acid without the cysteine included in the oligopeptide is preferably selected from the group of glycine, alanine, valine, methionine, proline, threonine, asparagine, glutamine, asparatic acid, glutamic acid, lysine, arginine and histidine. The reducing agent is preferably anhydrous sodium sulfite, sodium hydrogen sulfite, sodium pyrosulfite and sodium thiosulfite.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair composition containing a novel peptide and a reducing agent, and more particularly, to a hair composition that is safe and effective without causing damage to the hair. The present invention relates to a hair composition capable of controlling the amount of hair.

[0002]

2. Description of the Related Art In recent years, there has been a growing need to produce a desired hairstyle while maintaining beautiful hair, and there has been a demand for the development of a technique for easily and safely controlling a hairstyle without damaging the hair. I have.

[0003] Conventionally, as a method of controlling the shape of the hair, a permanent agent and a styling agent have been usually used. Generally, the perm agent mainly contains a reducing agent such as thioglycols and salts thereof, or cysteine, and usually contains an alkali agent, a surfactant, a stabilizer, a hair restorer, etc. for making the reducing action more effective. A first agent;
It comprises a second agent containing an oxidizing agent as a main component and a surfactant, a stabilizer, a hair restorer, and the like. The mechanism of controlling the shape of the hair by the perm agent is considered as follows. The components of the hair are chemically composed mainly of keratin, and as shown in FIG. 5A, the polypeptide chains 1, 1...
Are composed of side chains 2, 2... Such as SS bonds (disulfide bonds) connecting the two. Since each of the polypeptide chains 1, 1 ... is connected by adjacent side chains 2, 2 ..., the hair has elasticity, and no force exceeding the limit point is applied even if the hair is folded or stretched. As long as it has the power to return immediately. The restoring force is controlled by cutting and temporarily losing the side chains 2, 2,... By the action of the perming agent, and then rejoining the side chains 2, 2,. That is, by the action of the reducing agent as the first agent of the perm agent, the SS bond (disulfide bond) between the polypeptide chains 1 and 1 is broken to weaken the restoring power of the hair (FIG. 5 (b)). After adjusting the shape with a rod or the like, an oxidizing agent such as potassium bromate, sodium bromate, or hydrogen peroxide is acted on to restore the SS bond at a new position as shown in FIG. 5 (c). The hair is controlled by adjusting the shape of the hair.

However, in reoxidation after reduction with a permanent agent, the SS bond is not completely regenerated,
This causes hair damage such as a decrease in strength and elasticity of the hair. In addition to the problem that the reducing agent itself has a unique odor, an alkali agent is used as an auxiliary agent to increase the reducing power of the reducing agent or to swell the hair and improve the permeability of the active ingredient. Although it is generally used, there is a problem that this further causes hair damage.

[0005] On the other hand, in recent years, various styling agents containing a high molecular polymer have been marketed in order to easily control a hairstyle. In these products, hair is coated with a polymer to exert its setting power. This styling agent is considered to have little damage to the hair, but has the problem that the effect is immediately lost by washing the hair, in addition to the problem of feeling that the hair is stiff when used.

On the other hand, as means for solving the problems caused by the above-mentioned perm agent, for example, Japanese Patent Application Laid-Open No. 55-5109
No. 5 proposes a method using a keratin hydrolyzate having two or more mercapto groups in one molecule. However, this method is characterized in that the peptide used forms an SS bond on the surface of the hair and controls the shape of the hair by polymerizing the hair. However, it is still insufficient in terms of the degree and sustainability of the effects.

Japanese Patent Application Laid-Open No. Sho 56-30909 proposes a method using a keratin hydrolyzate having a molecular weight of less than 2,000, which has a breaking action of an SS bond in hair. Also in this case, the peptide itself is characterized by a polymerization action on the hair surface and less than two mercapto groups present in one molecule of the hydrolyzate,
This method is still inadequate in terms of the degree and sustainability of the effect, and is completely different from the technical idea of the present invention.

Furthermore, Japanese Patent Application Laid-Open No. 61-137899 proposes the application of thioredoxin and dithiol peptides derived from thioredoxin to hairdressing agents. However, for this thioredoxin,
Inferring from its molecular weight (MW: 10,000-13,000),
Due to the difficulty of penetrating into the hair, the effect is not sufficient and the range of action is limited. Furthermore, for dithiol peptides derived from thioredoxin,
There is a problem that a specific peptide sequence is indispensable for the expression of the effect, so that the practicality is not sufficient.

[0009]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems and circumstances of the prior art, and can effectively control the shape of hair without damaging the hair. It is intended to provide a hair composition whose effects are sustainable.

[0010]

Means for Solving the Problems The present inventors have conducted intensive studies in order to achieve the above object, and as a result, have found that a molecule containing two or more cysteines in the molecule and amino acids other than cysteine are of the same type. By using a specific peptide consisting of, together with a commonly used reducing agent, a higher wave effect can be obtained as compared with the case of using the reducing agent alone, and when a peptide according to the present invention is used in combination, in a normal permanent treatment, 2. The amount of oxidizing agents such as potassium bromate and hydrogen peroxide used as two agents can be greatly reduced, and a sufficient effect can be obtained even when the hair is treated near neutrality, and the damage to the hair can be reduced. Thus, the present invention succeeded in obtaining a hair composition, and completed the present invention.

That is, the hair composition of the present invention includes the following (1) and (2). (1) At least one oligopeptide having at least 3 amino acid residues and having two or more cysteines in the molecule and having amino acids other than cysteine consisting of the same kind of amino acids.
A hair composition comprising a seed and a reducing agent. (2) Amino acids of the same species other than cysteine contained in the oligopeptide are amino acids selected from glycine, alanine, valine, methionine, proline, threonine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, and histidine. Is above
The hair composition according to (1).

[0012]

Embodiments of the present invention will be described below in more detail. A hair composition according to the present invention comprises two or more cysteines (Cys) in one molecule, and the amino acid other than cysteine is the same kind of amino acid, and has three or more amino acid residues. And preferably one or more of 3 to 10 peptides (hereinafter abbreviated as "the peptide"), and a reducing agent usually used in hair compositions. In the present invention, examples of the same kind of amino acids other than cysteine include glycine (Gly), alanine (Ala), valine (Val), methionine (Met), proline (Pro), threonine (Thr), and asparagine (Asn). , Glutamine (Gln), aspartic acid (Asp), glutamic acid (Gl
u), lysine (Lys), arginine (Arg), and histidine (His). Among these amino acids, from the viewpoint of the wave effect, preferably, alanine (Ala), proline (Pro), asparagine (Asn), aspartic acid (Asp), histidine (Hi)
Preferably, it is an amino acid selected from s).

In the peptide of the present invention, a high wave effect can be obtained by including two or more residues of cysteine (Cys) in one molecule, and when the number of cysteine (Cys) is less than two residues. This is not preferable because a wave effect cannot be obtained. In addition, the reason why amino acids other than cysteine were of the same species was that amino acids having a high waving effect could be limited and production was easy, and when amino acids other than cysteine were heterologous, the waving effect depended on the type of amino acid. May be lost, and the production is complicated, which is not preferable. Further, if the polypeptide has more than 10 amino acid residues, the molecular weight becomes large, it is not possible to penetrate into the hair, and the internal function becomes difficult, which is not preferable.

Table 1 below shows, as specific examples of the peptide, oligopeptides consisting of cysteine (Cys) and proline (Pro) of 3 residues, 4 residues, and 5 residues, and Table 2 below.
Cysteine (Cys) and histidine (His)
The structural example of the oligopeptide of a residue is shown. Table 1 below
And the sequence numbers in Table 2 (the same applies to the following tables)
The sequence matches the sequence number described in the sequence listing described later. In the present invention, the peptide may be used as a single kind of peptide, or may be used as a mixture of various peptides usable in the present invention. The peptide is
Any of them can be obtained by a chemical synthesis method such as a liquid phase method or a solid phase method. In addition, the peptide is shown in FIG.
The sequence-type peptide synthesized according to the sequence of each residue shown in (1) or the amino acid mixture mixed at a ratio such that cysteine has two or more residues in the peptide is used as a raw material, and the peptide has a predetermined residue. As shown in FIG. 1B, the peptide may be a random peptide obtained by repeating a condensation reaction as shown in FIG. 1B, or may be used as a mixture of various peptides containing the peptide.

[0015]

[Table 1]

[0016]

[Table 2]

Next, in the present invention, as the reducing agent used simultaneously with the peptide, for example, either a compound having a mercapto group in the molecule or an inorganic reducing agent can be used. Preferably, reducing agents used in ordinary hair compositions, for example, thioglycolic acid, ammonium thioglycolate, monoethanolamine thioglycolate, L-cysteine, L-cysteine hydrochloride, DL-cysteine, DL-cysteine hydrochloride, N-acetyl-L
Cysteine and various sulfites, specifically one or two or more selected from anhydrous sodium sulfite, sodium bisulfite, sodium pyrosulfite, and sodium thiosulfite.
It is desirable to select and use more than one species.

In the present invention, by treating hair with a small amount of the peptide together with a reducing agent, it is possible to effectively control the shape without damaging the hair. That is, according to the present invention, it is possible to reduce the amount of the reducing agent required to obtain the same wave effect and increase the wave effect at a constant reducing agent concentration, as compared with the case where the reducing agent is used alone. Further, even if the oxidizing agent (two agents) used in the usual perm is significantly reduced, the same or more effect as that of the usual perm can be obtained. Furthermore, in order to obtain the above-mentioned effects, there is no need for the alkaline condition in the conventional perm agent, so that there is a feature that the damage to the hair is extremely small. In more detail).

To further illustrate the present invention, any formulation applicable to the hair, including a trace amount of one or more of the peptides together with a reducing agent, such as a liquid, cream or gel The purpose can be achieved by treating the hair with a preparation such as a shape. The amount of the reducing agent and the peptide in the preparation varies depending on the form of the preparation, the frequency of use, the treatment time, and the like. However, usually, the reducing agent is used in an amount of 0.1 to 11% by weight (hereinafter, referred to as the total amount of the hair composition). %), Preferably in the range of 0.5 to 7%. Depending on the type of reducing agent, if the amount is less than 0.1%, the reduction to the hair is insufficient, and if it exceeds 11%, damage to the hair may increase.

On the other hand, although the peptide varies depending on its molecular weight, it is usually 1% by weight relative to the amount of the reducing agent added.
/ 4000 to 1/10, preferably 1/2000 to
It is preferable to add so as to be 1/20. Addition amount is 1 /
If it is smaller than 4000, the effect of the peptide cannot be sufficiently obtained, and even if it is added in more than 1/10, the effect corresponding to the added amount cannot be increased.

The preparation used in the present invention can take any form as long as it can be applied to the hair as described above. Specifically, it can be widely used in various forms as an externally usable dosage form such as a lotion or a hair tonic type alcohol preparation, a hair cream, a hair lotion, an emulsion, an ointment, a hair treatment, a hair conditioner and the like. Also, those in liquid form are ordinary propellants,
For example, it can be used in combination with carbon dioxide gas, oxygen gas, LPG, etc., and filled in a pressure-resistant container.

Furthermore, these preparations may contain, in addition to the above-mentioned essential ingredients, other medicinal ingredients which can be generally formulated and which keep the hair healthy and promote hair growth, for example, vitamin A. Vitamins such as vitamin B6, pantothenic acid, and biotin; amino acids such as methionine and tyrosine; bactericides such as salicylic acid, hinokitiol, and resorcinol; and other hormones, if necessary.
Furthermore, oil components, surfactants, humectants, lower alcohols, thickeners, antioxidants, chelating agents, sensation imparting agents,
High polymers, pH adjusters, preservatives, fragrances, dyes, etc.
Raw materials usually used for these preparations can be blended.

[0023] The composition of the present invention may be used at any pH.
It is possible to show the effect in
To minimize the effect on skin and hair, pH
It is preferable to use in the range of 5.0 to 8.0. In treating hair with these compositions, the amount of the composition is sufficient to adjust the hair to the part where the hairstyle is to be controlled, for example, the part where the hair is to be added or the part where the hair is to be straightened. Is applied. Thereafter, the hair can be shaped into a desired shape by an arbitrary method, left for about 5 to 60 minutes, and then washed for use. Conversely, a method is also possible in which the hair is adjusted to a desired shape in advance and then the composition is applied.

In the present invention, after the treatment with the composition of the present invention, a treatment with an oxidizing agent used for a normal permanent treatment can be performed. In this case, the amount of the oxidizing agent used is greatly reduced as compared with the usual case. However, the same effect can be obtained. Also, even when no oxidizing agent is used,
A sufficient effect and its durability can be obtained. Furthermore, the composition of the present invention can also be used without shampooing after application by controlling the type and amount of the reducing agent (these points are further described in Examples and the like described below). explain in detail).

[0025]

EXAMPLES Next, the present invention will be described in more detail with reference to Production Examples and Test Examples of Examples and Comparative Examples, but it should be understood that the present invention is not limited to these Examples.

(Production Example 1) Production method by sequence (solid phase method): Cys His Cys Hi
Preparation Example of s After protecting the amine group of His with a 9-fluorenylmethoxycarbonyl group (Fmoc group), N, N-dicyclohexylcarbodiimide was added to prepare Fmoc-His anhydride. The resin was immobilized thereon using dimethylaminopyridine as a catalyst. The resin was then washed with dimethylformamide containing piperidine to remove the protecting group for the C-terminal amine function. In addition, the Fmoc-Cys anhydride corresponding to the second from the C-terminus of the amino acid sequence was coupled to the His deprotected amine function described above. The same applies to Hi
s and Cys were fixed. Thereafter, removal of protecting groups other than acetamidomethyl and elimination of the peptide were carried out with a solvent consisting of 94% TFA, 5% phenol and 1% ethanediol, the peptide was purified by high performance liquid chromatography, and the solution was concentrated. After drying, a powdery synthetic peptide was obtained.

(Production Example 2) Production method by random (solid phase method): Production example of Cys His Cys His His-resin and Cys-resin (1) produced by the same method as the production method by the sequence of Production Example 1 above : 1) and Fmoc-His
An anhydride and Fmoc-Cys anhydride (1: 1) were prepared and coupled. Thereafter, the protecting group of the coupled C-terminal amine function was removed. Furthermore, a new Fmoc-Hi
s anhydride and Fmoc-Cys anhydride (1: 1) were added and coupled. These operations were repeated to produce a desired peptide. After completion of the synthesis, the protecting group other than acetamidomethyl was removed and the peptide was eliminated with a solvent consisting of 94% TFA, 5% phenol and 1% ethanediol, and the peptide was purified by high performance liquid chromatography. After concentration and drying, a powdery synthetic peptide was obtained.

[Test Example 1 (Examples 1 to 9 and Comparative Examples 1 to 9)
3)] The effect of improving the wave when the peptide was added together with various reducing agents was examined. That is, Table 3 below
The hair bundle was treated with a treatment solution prepared by dissolving various reducing agents and peptides shown in the above in pH 7 100 mM phosphate buffer, and the wave ratio (%) obtained at that time was measured by the method shown below. . The results are shown in Table 3 below.

[Measurement method of wave rate (%)] A set of 20 healthy hairs (70 mm) of a Japanese woman was made into a bundle, washed with 20% sodium polyoxyethylene lauryl ether sulfate, and then placed on a 35 mm hair bundle. Evaluation sites were set (FIG. 2).
Next, the hair bundle is put in a processing container, and after a holder for fixing the hair bundle is placed, a processing solution is added so that the hair bundle is sufficiently immersed, and the temperature is set at 30 ° C.
The treatment was performed for 30 minutes (FIG. 3). After the treatment, the hair bundle is thoroughly rinsed with ion-exchanged water, and then air-dried at room temperature.
The distance (Xmm) between the evaluation sites set to mm was measured (FIG. 4), and the wave ratio (%) was determined by the following equation. The peptides shown in Table 3 below were produced according to Production Example 1 described above and a sequence-type production method.

[0030]

Embedded image

[0031]

[Table 3]

(Consideration of Table 3) As is apparent from the results of Table 3, Examples 1 to 9 according to the present invention, in which the peptide was added together with various reducing agents, were compared with Comparative Examples 1 to 9 in the case of using only the reducing agent. Compared with No. 3, a remarkable improvement in the wave ratio was observed.

The hair bundles of Examples 1, 6, and 7 were replaced with 2
It was immersed in a 0% sodium polyoxyethylene lauryl ether sulfate solution at 60 ° C. for 60 minutes, washed with ion-exchanged water, air-dried at room temperature, and the web ratio was measured again. The obtained web ratio was divided by the web ratio before the surfactant treatment to determine a web retention ratio. As a result, Example 1 showed a web retention of 96.2%, Example 6 showed 96.7%, and Example 7 showed 94.8% of the web retention. It was found that a good web ratio and excellent web retention could be obtained without using.

Further, a test was conducted in the same manner as in Example 1 by using the peptides described in the following 1) to 3) (produced by the random production method in Production Example 2) instead of the peptide used in Example 1. As a result, a remarkable improvement in the wave ratio was observed in any of the combinations with any of the reducing agents as compared with the case of using only the reducing agent, and almost the same effect as in Example 1 could be obtained. .

1) Cysteine (Cys) and histidine (Hi
A 4-residue or 6-residue peptide mixture obtained by repeating a condensation reaction a predetermined number of times using an amino acid mixture containing s) in a ratio of 1: 1 as a raw material. 2) A 6-residue peptide mixture obtained by repeating a predetermined number of condensation reactions with an amino acid mixture containing cysteine (Cys) and proline (Pro) at a ratio of 1: 2 as a raw material. 3) Cysteine (Cys) and alanine (Ala), or cysteine (Cys) and asparagine (Asn), or cysteine (Cys) and aspartic acid (Asp), or cysteine (Cys) and lysine (Lys) A four-residue peptide mixture obtained by repeating a predetermined number of condensation reactions with an amino acid mixture containing various combinations at a ratio of 1: 1 as a raw material.

[Test Example 2 (Examples 10 and 11 and Comparative Examples 4 and 5)] Using Examples 10 and 11 and Comparative Examples 4 and 5 (Compositions A to D) shown in Table 4 below, Examples The web ratio was measured in the same manner as in Example 1. Table 4 below also shows these results. The peptides shown in Table 4 below were produced according to Production Example 1 described above and a sequence-type production method.

[0037]

[Table 4]

(Consideration of Table 4) As is clear from the results of Table 4, Examples 10 and 11 (Composition A,
By performing the treatment using B), the concentration of the reducing agent required to obtain the same web effect can be extremely small, and Comparative Example 4 in the case of the treatment with the same concentration of the reducing agent alone, It was found that a significantly higher web ratio was obtained as compared with No. 5 (compositions C and D).

Test Example 3 (Examples 12 to 14 and Comparative Examples 6 to 8) Using the components shown in Tables 5 and 6, the first and second agents for the permanent treatment liquid were prepared and Permanent treatment was performed using the device shown in Example 1 and the same hair bundle as in Example 1. The permanent treatment was performed under the conditions of the first agent treatment at room temperature for 20 minutes and the second agent treatment at room temperature for 10 minutes. After the treatment, the wave ratio was measured in accordance with the method of Example 1, and the hair bundle was further treated under the conditions of 20 ° C. and 65% humidity.
After humidity control, the tensile strength of the hair was measured to estimate the degree of hair damage. The results are shown in Tables 5 and 6 below. The peptides shown in Tables 4 and 5 below were produced according to Production Example 1 described above and a sequence-type production method.

[0040]

[Table 5]

[0041]

[Table 6]

(Consideration of Tables 5 and 6) Tables 5 and 6 above
As is clear from the results of Examples 12 to
By treating the hair on the basis of No. 14, compared with Comparative Examples 6 to 8 in which the same concentration of the reducing agent alone was used, an excellent wave imparting effect could be obtained without substantially reducing the strength of the hair.

Test Example 4 (Examples 15 to 18 and Comparative Examples 9 to 10) The compositions shown in Table 7 below were prepared, and 5 g of each of these compositions was applied to healthy Japanese hair (25 cm, 5 g). After applying, the hair was wound around a rod and left at room temperature for 30 minutes. Thereafter, the hair was removed from the rod, rinsed thoroughly with ion-exchanged water, and air-dried at room temperature. The wave forming properties of these treated hairs were organoleptically evaluated using a specialized panel according to the following evaluation criteria (1).

Evaluation Criteria (1) Wave Formability: ：: Extremely Good 良好: Good Δ: Normal ×: Poor

Further, the hair after the evaluation was washed with a commercially available shampoo in a usual manner, and then air-dried at room temperature.
After repeating this operation five times, the treated hair was visually evaluated for the wave retention based on the following evaluation criteria (2) using a specialized paneler.

Evaluation Criteria (2) Wave Retention (Based on Wave Amount Before Hair Washing): ：: Equal Δ: Slight decrease ×: Decrease The results of these evaluations are shown in Table 7 below.

[0047]

[Table 7]

(Consideration of Table 7) As is evident from the results of Table 7, Examples 15 to 18 according to the present invention showed much better web formation than Comparative Examples 9 to 10 in which the peptide was not added. Properties and wave retention were obtained.

Next, using the peptide of the present invention, the following hair cosmetics, ie, lotion, hair mousse, hair cream, hair oil and permanent waving agent were produced. By using the peptide of the present invention, any of the hair cosmetics was able to obtain good wave-forming properties and wave-retaining properties.

(Composition of lotion) Decamethylcyclopentasiloxane 15.0% by weight Dimethylpolysiloxane (n = 3000) 3.0 1,3-butylene glycol 2.0 Polyoxyethylene hydrogenated castor oil (60EO) 2.0 N-acetyl-cysteine 1.0 Peptide (Cys His Cys His) 0.05 Ethanol 15.0 Water Balance Perfume Appropriate amount (Adjust pH to 8.0 with monoethanolamine)

(Blending composition of hair mousse) Octamethylcyclosiloxane 10.0 Dimethylpolysiloxane (n = 10000) 2.0 Glycerin 1.0 Polyoxyethylene hydrogenated castor oil (120EO) 2.0 N-acetyl-cysteine 1.0 Peptide (Cys His Cys His) 0.05 Ethanol 10.0 water balance n-butane 7.0 perfume appropriate amount (pH adjusted to 8.0 with monoethanolamine)

(Blending Composition of Hair Cream) Decamethylcyclopentasiloxane 25.0% by weight Dimethylpolysiloxane (n = 10000) 3.0 Glycerin 3.0 Polyoxyethylene hydrogenated castor oil (120EO) 3.0 N-acetyl-cysteine 1.0 peptide (Cys His Cys His) 0.05 Ethanol 10.0 Water Balance Polyvinyl alcohol 1.0 Perfume Appropriate amount (Adjust pH to 8.0 with monoethanolamine)

(Blending composition of hair oil) Decamethylcyclopentasiloxane 57.0% by weight Dimethylpolysiloxane (5cps) 3.0 Dimethylpolysiloxane (n = 7000) 3.0 N-acetyl-cysteine 1.0 Peptide (Cys His Cys His) 0.05 Ethanol 10.0 Perfume Appropriate amount (pH adjusted to 8.0 with monoethanolamine)

(Blending composition of agent for permanent wave) 1 solution 6.0% ammonium thioglycolate 6.0% by weight Peptide (Cys Ala Cys Ala) 0.06 Water suitable amount (pH adjusted to 8.0 with monoethanolamine) 2 solution Bromic acid Sodium 4.0 Purified water qs

(Blending composition of hair treatment) Stearyl trimethyl ammonium chloride 3.0% by weight Cetanol 1.5 Glycerin monostearate 1.5 1,3-butylene glycol 5.0 N-acetyl-cysteine 1.0 Peptide (Cys Ala Cys Ala) 0.05 Liquid paraffin 2.0 Dye Suitable amount Perfume qs water 0.5 (pH adjusted to 8.0 with monoethanolamine)

[0056]

According to the present invention, at least one kind of oligopeptide having 3 or more amino acid residues containing at least two cysteines in the molecule and having amino acids other than cysteine of the same kind is used. Is used together with a reducing agent usually used for a permanent agent, whereby a higher wave effect can be obtained as compared with a case where the reducing agent is used alone.
In normal perm treatment, the amount of oxidizing agent such as potassium bromate used as two agents can be greatly reduced, and a sufficient effect can be obtained even if the treatment of hair is performed near neutrality, and hair damage is low. A hair composition is provided.

[Sequence list]

 SEQ ID NO: 1 Sequence length: 3 Sequence type: amino acid Topology: linear Sequence type: peptide sequence Cys Pro Cys 1 SEQ ID NO: 2 Sequence length: 4 Sequence type: amino acid Topology: linear Sequence type: Peptide sequence Cys Pro Pro Cys 1 SEQ ID NO: 3 Sequence length: 4 Sequence type: amino acid Topology: linear Sequence type: Peptide sequence Cys Pro Cys Pro 1 SEQ ID NO: 4 Sequence length : 4 Sequence type: amino acid Topology: linear Sequence type: peptide sequence Pro Cys Pro Cys 1 SEQ ID NO: 5 Sequence length: 5 Sequence type: amino acid topology: linear Sequence type: peptide sequence Cys Pro Pro Pro Cys 15 SEQ ID NO: 6 Sequence length: 5 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Pro Pro Cys Pro 15 SEQ ID NO: 7 Sequence length: 5 Sequence Type: amino acid topo Theory: Linear Sequence Type: Peptide Sequence Cys Pro Cys Pro Pro 15 SEQ ID NO: 8 Sequence Length: 5 Sequence Type: Amino Acid Topology: Linear Sequence Type: Peptide Sequence Pro Cys Pro Pro Cys 1 5 SEQ ID NO: 9 Sequence length: 5 Sequence type: amino acid Topology: linear Sequence type: peptide sequence Pro Cys Pro Cys Pro 15 SEQ ID NO: 10 Sequence length: 5 Sequence type: amino acid topology : Linear sequence type: Peptide sequence Pro Pro Cys Pro Cys 15 SEQ ID NO: 11 Sequence length: 5 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Pro Cys Pro Cys 15 SEQ ID NO: 12 Sequence length: 5 Sequence type: amino acid Topology: linear Sequence type: peptide sequence Cys Cys Pro Cys Pro 15 SEQ ID NO: 13 Sequence length: 5 Sequence type: amino acid Topology: Species of linear sequence Class: Peptide sequence Cys Pro Cys Cys Pro 15 SEQ ID NO: 14 Sequence length: 5 Sequence type: amino acid Topology: Linear Sequence type: Peptide sequence Pro Cys Pro Cys Cys 15 SEQ ID NO: 15 Sequence Length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys His His His His Cys 15 SEQ ID NO: 16 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence Type: Peptide sequence Cys His His His Cys His 15 SEQ ID NO: 17 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys His His Cys His His 15 SEQ ID NO: 18 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys His Cys His His His 15 SEQ ID NO: 19 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Pep Tide sequence His Cys His His Cys 15 SEQ ID NO: 20 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide Sequence His Cys His His Cys His 15 SEQ ID NO: 21 Sequence Length: 6 Sequence type: amino acid Topology: linear Sequence type: peptide sequence His Cys His Cys His His 15 SEQ ID NO: 22 Sequence length: 6 Sequence type: amino acid Topology: linear sequence Type: Peptide sequence His His Cys His His Cys 15 SEQ ID NO: 23 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence His His Cys His Cys His 15 SEQ ID NO: 24 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence His His His Cys His Cys 15 SEQ ID NO: 25 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Pep Tide sequence Cys His Cys His Cys His 15 SEQ ID NO: 26 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys His Cys His His Cys 15 SEQ ID NO: 27 Sequence Length: 6 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys His His Cys His Cys 15 SEQ ID NO: 28 Sequence length: 6 Sequence type: Amino acid Topology: Linear Sequence Type: Peptide sequence His Cys His Cys His Cys 15 SEQ ID NO: 29 Sequence length: 4 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Pro Cys Cys 1 SEQ ID NO: 30 Sequence length Length: 5 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Ala Ala Cys Ala 15 SEQ ID NO: 31 Sequence length: 4 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys His Cys His 1 SEQ ID NO: 32 Sequence length: 4 Sequence type: amino acid Topology: Linear Sequence type: Peptide sequence Cys His His Cys 1 SEQ ID NO: 33 Sequence length: 3 Sequence type: Amino acid Topology: linear Sequence type: peptide sequence Cys Asp Cys 1 SEQ ID NO: 34 Sequence length: 4 Sequence type: amino acid Topology: linear Sequence type: peptide sequence Cys Lys Lys Cys 1 SEQ ID NO: 35 Sequence length: 4 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Asp Cys Asp 1 SEQ ID NO: 36 Sequence length: 4 Sequence type: Amino acid Topology: Linear Sequence type : Peptide sequence Cys Lys Cys Lys 1 SEQ ID NO: 37 Sequence length: 4 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Glu Glu Cys 1 SEQ ID NO: 38 Sequence Length: 5 Sequence type: Amino acid Topology: Linear Sequence type: Peptide sequence Cys Lys Lys Lys Cys 15 SEQ ID NO: 39 Sequence length: 4 Sequence type: Amino acid Topology: Linear Sequence Type: peptide sequence Cys Pro Cys Pro 1

[Brief description of the drawings]

FIG. 1A is a diagram showing an example of the synthesis of a sequence-type peptide synthesized according to the sequence of each residue,
(B) is a diagram showing a synthesis example of a random peptide obtained by repeating a condensation reaction.

FIG. 2 is a diagram for explaining a method of measuring a wave rate,
It is the figure which gave the mark for position identification to the hair bundle.

FIG. 3 is a diagram illustrating a method of measuring a wave rate,
It is a figure which immerses a hair bundle in a processing container.

FIG. 4 is a diagram for explaining a method of measuring a wave rate,
FIG. 7 is a view showing a state where a distance of a processing part can be measured.

FIG. 5 (a) is a schematic diagram showing the components of hair, (b)
Is a schematic diagram showing a state in which an SS bond (disulfide bond) between polypeptide chains has been cleaved, and (c) is a schematic diagram showing a state in which the SS bond has been restored at a new position and the shape of the hair has been adjusted. FIG.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI C07K 7/06 C07K 7/06

Claims (2)

[Claims] 1. A reducing agent comprising at least one oligopeptide containing two or more cysteines in the molecule and having three or more amino acid residues in which amino acids other than cysteine are composed of the same kind of amino acid, and a reducing agent. A hair composition, comprising: 2. The same kind of amino acid other than cysteine contained in the oligopeptide is selected from glycine, alanine, valine, methionine, proline, threonine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine and histidine. The hair composition according to claim 1, which is an amino acid which is obtained.