JPH107578A - Composition for throat - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for a throat capable of diminishing an uncomfortable feeling in the throat caused by an irritation caused by a microorganisms such as viruses and bacteria, chemicals, dusts and acarids on the throat by combining Kyoseihatekigan (a combined crude medicine) with a stevia. SOLUTION: This composition for a throat is obtained by combining a stevia with a food blended with Kyoseihatekigan having the component ratio of 2.5 pts.wt. Forsythiae Fructus, 2.5 pts.wt. Platycodon grandiflorum, 2.5 pts. wt. Glychyrrhizae Radix, 1.0 pt.wt. Amomi Semen, 1.0 pt.wt. Cnidium officinale, 1.0 pt.wt. Terminalia chebula, 2.0 pts.wt. Acacia catechu, 4.0 pts.wt. Menthae Herba and 1.0 pt.wt. Rhei Rhizoma. A feeling when taking the medicine is improved because the uncomfortable irritating feeling such as a specific bitter, astringent or harsh taste is reduced.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improvement in the taste (feeling of taking) of a food for throat containing Hikyohatomaru.

[0002]

2. Description of the Related Art Throat discomfort generally occurs during pharyngitis and laryngitis, and is caused by irritation of the throat by microorganisms such as viruses and bacteria, chemical substances, dust, ticks, and the like. . For such discomfort of the throat,
Oral preparations containing pharmaceuticals such as antibiotics, bactericides and bronchodilators have been widely used.

On the other hand, elderly people, children, pregnant women, and the like tend to avoid the above-mentioned drugs due to the problem of side effects and prefer Chinese medicines that have been used since ancient times. Chinese herbal prescriptions for improving throat discomfort include Hibiki Tofukimaru, Gyokudoku Tokuto, Hojunto, and Hangatsu Kobokuto. Of these, Hibiki Hofuemaru is particularly popular.

[0004]

However, the aforementioned herbal medicine for the throat has a unique bitterness and irritating sensation, so that the feeling of taking it is poor and compliance (drug compliance) is a problem. In particular, Hibikihafumaru contains herbal medicines that have an unpleasant stimulus such as forsythia, oak, and assemblage. It is known that the feeling of taking is poor. In order to improve the feeling of taking, conventionally, a method of blending a sweetener such as sucrose, maltitol, and sorbitol has been used, but in the conventional method, if the bitterness is sufficiently reduced, the sweetness remains in the mouth, Also,
If the amount of the sweetener is suppressed to such an extent that the sweetness does not remain, there are drawbacks such as insufficient improvement in taking feeling and poor flavor. Therefore, there has been a demand for the development of a food for the throat of a Kampo formula having a good flavor (feeling of taking).

It is an object of the present invention to provide a herbal medicine effective for alleviating various symptoms of the throat as a savory food.

[0006]

Means for Solving the Problems As a result of repeated studies to solve the above-mentioned problems, the present inventors have found that, when stevia is further added to a food containing Hibiki Hafumaru, a unique bitterness is obtained. A feeling of unpleasant irritation such as astringency, egumi is remarkably reduced,
The inventor found that the feeling of taking was improved, and completed the present invention.
That is, the present invention is a composition for a throat characterized by incorporating Hibikihafumaru and Stevia.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Hibikihatomaru used in the present invention has 2.5 parts by weight of forsythia, 2.5 parts by weight of kyoto, 2.5 parts by weight of liquorice, 1.0 part by weight of shukusha, and 1.0 part by weight of Sengyu. The mixing ratio is 1.0 parts by weight of oak, 1.0 parts by weight of oak, 2.0 parts by weight of menthol, 4.0 parts by weight of mint, and 1.0 part by weight of rhubarb. The present invention is also effective in a formulation containing no rhubarb. . For each crude drug, its extract is usually used. The extract is extracted by a conventional method. As the extract, a dry extract powder obtained by a spray drying method of the extract, a concentrated extract of the extract, and the like can be used.

[0008] In the present invention, stevia is St.
evia Rebaudiana Bertoni is a sweetener mainly composed of sweet components contained in the leaves of perennial plants of the Asteraceae family. Stevioside, rebaudioside A, zurcoside A, zurcoside B, rebaudioside E, rebaudioside. D, a mixture of known stevia extracts such as steviolbioside, rebaudioside B, and steviol, or a component obtained by isolating one of these components. The known stevia extract is treated with an enzyme or chemically. Including those that performed Among these, those having a content of rebaudioside A of 36% by weight or more are preferable in terms of flavor, and 100% of rebaudioside A is contained.
Are most preferred.

[0009] Stevia is incorporated in an amount of 0.0001 to 0.02 parts by weight, preferably 0.001 to 1.0 parts by weight of stevia per 1 part by weight of the original drug equivalent of Hibiki Hachimaru.
0.01 parts by weight.

The composition for the throat of the present invention can be prepared into candies, lozenges, drops and the like by ordinary methods, and tablets, granules, fine granules, powders, capsules, chewables, foaming agents, dissolving agents in the mouth. And pharmaceutical preparations for oral administration such as dry syrups and oral liquids.

At the time of production, other additives such as excipients, disintegrants, binders, lubricants, antioxidants, coloring agents, fresheners, surfactants, plasticizers, solubilizing agents, if necessary. Agents, buffers, preservatives, fragrances, dyes, cooling agents and the like can be used.

[0012] Examples of the excipient include maltitol, mannitol, xylitol, sorbitol, glucose,
Sucrose, lactose, light silicic anhydride, crystalline cellulose, crystalline cellulose and sodium carboxymethylcellulose, calcium hydrogen phosphate, starch (wheat, rice, corn, potato, etc.), sodium carboxymethyl starch, dextrin, α-dextrin, β -Dextrin, carboxyvinyl polymer, titanium oxide,
Examples include magnesium aluminate metasilicate, polyethylene glycol, and medium chain fatty acid triglycerides.

Examples of the disintegrant include low-substituted hydroxypropylcellulose, sodium carboxymethylcellulose, croscarmellose sodium A type (actisol), starch, crystalline cellulose, hydroxypropyl starch, partially pregelatinized starch and the like.

Examples of the binder include methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polypinylpyrrolidone, gum arabic, ethylcellulose, polyvinyl alcohol, pullulan, pregelatinized starch, agar, tragacanth, sodium alginate, propylene glycol alginate and the like. Is raised.

Examples of the lubricant include stearic acid, magnesium stearate, calcium stearate, cetanol, talc, hydrogenated oil, sucrose fatty acid ester, microcrystalline wax, beeswax, and beeswax.

Examples of the antioxidant include dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHA), α-tocopherol,
Citric acid and the like.

Examples of the coloring agent include tar dyes and titanium oxide.

Examples of the cooling agent include dl-menthol, l-menthol, peppermint oil, peppermint oil, eucalyptus oil, tinc oil and the like.

Examples of the surfactant include polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopartimate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymer, polysorbates, sodium lauryl sulfate, macrogol And sucrose fatty acid esters.

Examples of the plasticizer include triethyl citrate, triacetin, cetanol and the like. The composition for the throat of the present invention is usually 3 to 20 g, and most preferably 8 to 9 g, in terms of the amount of the crude drug of Hibiki Hachimaru for an adult.
Is orally administered as an extract once or several times a day. The form is preferably a candy, a troche, a drop or the like, and it is melted slowly and tasted in the mouth 2-3 times a day. This amount can be appropriately increased or decreased depending on age, body weight, medical condition and the like.

[0021]

The present invention will be described in more detail with reference to the following examples and test examples.

Example 1 Hikyoku Houteki Maru Extract (Matsuura Pharmaceutical Co., Ltd.) 1900 g (equivalent to crude drug: 8.25 kg) Stevia 15 g Granulated sugar 5400 g Syrup 3800 g Purified water 2200 g l-menthol 9 g Granules in stainless steel container Sugar, starch syrup and purified water were weighed and heated at 100 ° C. to dissolve. Put this in a heating can and concentrate under reduced pressure at 150 ° C.
Stevia and l-menthol were added and mixed well. After cooling, the mixture was kneaded with a kneading machine, and 6,000 lozenges were produced using a sizing roller.

Example 2 Hibiki Haofue Marui Extract 1900 g Stevia 15 g Maltitol 5400 g Syrup 3800 g Purified water 2200 g l-Menthol 9 g In a stainless steel container, maltitol, syrup and purified water are weighed and heated to 100 ° C. to dissolve. Was. Put this in a heating can and concentrate under reduced pressure at 150 ° C.
Stevia and l-menthol were added and mixed well. After cooling, the mixture was kneaded with a kneading machine, and 6,000 lozenges were produced using a sizing roller.

COMPARATIVE EXAMPLE 1 Hikyoku Houteki Maru Extract 1900 g Granulated sugar 5400 g Syrup 3800 g Purified water 2200 g l-Menthol 9 g Granulated sugar, starch syrup and purified water were weighed in a stainless steel container and dissolved by heating at 100 ° C. Put this in a heating can and concentrate under reduced pressure at 150 ° C.
l-Menthol was added and mixed well. After cooling, the mixture was kneaded with a kneading machine, and 6,000 lozenges were produced using a sizing roller.

COMPARATIVE EXAMPLE 2 Hikyoku Houteki Maru Extract 1900 g Maltitol 5400 g Syrup 3800 g Purified water 2200 g l-Menthol 9 g Maltitol, syrup and purified water were weighed in a stainless steel container and dissolved by heating at 100 ° C. Put this in a heating can and concentrate under reduced pressure at 150 ° C.
l-Menthol was added and mixed well. After cooling, the mixture was kneaded with a kneading machine, and 6,000 lozenges were produced using a sizing roller.

Test Examples: Questionnaire Survey on Flavor (1) Panelists: 13 adults (6 males, 7 females) exhibiting cold symptoms in their 20s to 50s (2) Test method: Examples 1 to In order to maintain the objectivity of the test, the troches of Comparative Example 2 and Comparative Examples 1-2 were taken in an arbitrary and blinded manner (the contents were not known to the panelists), and then a method of answering questionnaires was used. .

Questionnaire evaluation methods are as follows: 1)
Smell / fragrance, 2) sweetness, 3) pungency, 4) bitterness, 5) acidity, 6) astringency / egumi, 7) body, 8) aftertaste divided into 7
Judgment was made based on a perfect score.

FIG. 1 shows the results.

[0029]

As is evident from the results shown in FIG. 1, the present invention was able to improve the flavor of the composition containing the Chinese herb medicine and Hibiki Fuemaru, so that the food for the throat with an excellent feeling of ingestion was obtained. It has become possible to provide a throat medicine.

[Brief description of the drawings]

FIG. 1 shows the results of a questionnaire on taste in Test Example 1.

Claims (1)

[Claims] 1. A composition for the throat, characterized by containing Hibikihafumaru and Stevia.