JPH1067627A - Organism active glass-containing composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity capable of uniformly forming a hydroxyapatite film on the surface of enamel of the teeth in a short time and effective for prevention of dental caries by mixing a specific glass material. SOLUTION: This composition contains one or more kinds of organism active glass. As to the organism active glass, glass comprising 10-70wt.% of SiO2 and 5-60wt.% of CaO, especially one comprising 1-60wt.% of SiO2 , 5-50wt.% of CaO and 0-30wt.% of Na2 O is preferable. Furthermore, one or more kinds of inorganic compounds selected from the group of P2 O5 , K2 O, Li2 O, TiO2 , Al2 O3 , MgO, B2 O3 , ZrO2 and CaF2 may be mixed. Preferably, a size of the organism active glass is <32 mesh pass. Preferably, a mixing amount of the organism active glass into the composition for oral cavity is 0.001-50wt.%. This composition for oral cavity is useful as a dentifrice or a mouth washing agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an oral composition for forming a hydroxyapatite film on a tooth surface.

[0002]

2. Description of the Related Art It is known that when an artificial material is implanted into a bone defect, a protective reaction occurs in a living body. However, some glasses and ceramics naturally bind to living tissue. It is called a bioactive material. Bioactive glass having bioactivity is one of them, and is already used as an artificial bone or an artificial tooth root.

[0003] These bioactive glasses can be broadly classified into bioactive crystallized glass containing crystals such as apatite and wollastonite in the glass, and ordinary bioactive glass containing no such crystals. For example,
No. 10939 discloses a crystallized glass for artificial bone containing apatite and wollastonite crystals and a method for producing the same. The crystallized glass has excellent biocompatibility,
It describes that it forms a chemical bond directly with bone and has excellent mechanical strength.

[0004] Japanese Patent Application Laid-Open No. 6-30984 discloses that
In artificial bone made of glass or crystallized glass containing CaO and SiO ₂ as main components, by adjusting the amount of Ca ²⁺ ions eluted by binding a hydrophobic group to the glass surface,
There is disclosed a technique for preventing deterioration of glass strength. JP-A-5-31166 discloses a technique in which a metal such as titanium is coated with a bioactive glass and used as a bone replacement material.

[0005] Further, Japanese Patent Application Laid-Open No. 2-255515 discloses that bone-repair materials, implantable medical instruments and equipment, medical supplies, artificial organs using bioactive glass regardless of inorganic materials, metallic materials, and organic materials. For example, a method of forming a bioactive apatite film similar to bone in a living body on the surface of all materials used in the living body is disclosed.

[0006] On the other hand, in the field of oral preparations, it is known to form a hydroxyapatite film on the tooth surface using a calcium phosphate compound. For example, NaCl, KCl, Mg
A technique of adding a chloride such as Cl ₂ to increase the solubility in water to coat the tooth surface (Japanese Patent Application Laid-Open No. 56-73015) is known. Further, a technique for converting carbonate apatite into hydroxyapatite under neutral or weakly alkaline conditions (Japanese Patent Laid-Open No. 70408/1988), or a method for converting a dentifrice composition containing a calcium salt into water (saliva) in the oral cavity. Underneath, it is converted to hydroxyapatite (JP-A-7-22930)
Publication) technology is disclosed. However, such a current oral composition cannot uniformly coat the tooth surface in a short period of time, and thus cannot exhibit an effective caries prevention effect.

[0007]

SUMMARY OF THE INVENTION An object of the present invention is to provide a bioactive glass-containing oral composition capable of forming an excellent hydroxyapatite film on a tooth surface and effectively preventing dental caries.

[0008]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventor has found that by blending a bioactive glass with an oral composition, the tooth surface can be uniformly dispersed in a short time. The present inventors have found that a hydroxyapatite film can be formed on the substrate, and have completed the present invention.

[0009] That is, the present invention provides an oral composition comprising one or more bioactive glasses. ADVANTAGE OF THE INVENTION According to this invention, the composition for oral cavity which can solve the above-mentioned problem and form a hydroxyapatite film | membrane on a tooth surface in a short time and uniformly and can prevent caries effectively can be provided.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The bioactive glass used in the present invention is not limited as long as it is a glass material that naturally bonds to the tooth surface, and bioactive crystallized glass containing crystals in the glass, or Any of the usual bioactive glasses that do not contain such crystals may be used. The composition of the bioactive glass, a SiO ₂ 10 to 70 wt% based on the entire glass, preferably contains a CaO 5 to 60 wt%, in particular, a SiO ₂ 10 to 60 wt%, Ca
O 5-50% by weight and Na ₂ O and preferably contains 0 to 30 wt%. 10% by weight of SiO _{2 in} glass
If it is less than the above, the affinity with the tooth surface is reduced, while 70
Exceeding the weight percent is not preferred because melting becomes difficult.
Further, if the content of CaO in the glass is less than 5% by weight, the affinity with the tooth surface is reduced, while if it exceeds 50% by weight, vitrification becomes difficult, which is not preferable. Na ₂ O makes the glass low-melting, but if it exceeds 30% by weight, the affinity with the tooth surface is lowered, which is not preferable.

In the oral composition of the present invention, one or more of these bioactive glasses may be used in combination.
0.001 to 50% by weight can be added to the whole oral composition. If the amount is less than 0.001% by weight, apatite is not formed on the tooth surface, while if it exceeds 50% by weight, the tooth surface is damaged, which is not preferable.

Further, the bioactive glass used in the present invention includes P ₂ O ₅ , K ₂ O, Li ₂ O, TiO ₂ , Al ₂ O ₃ , M
One or more inorganic compounds selected from the group consisting of gO, B ₂ O ₃ , ZrO ₂ , and CaF ₂ can be contained. Among these inorganic compounds, P ₂ O ₅ stabilizes the glass, K ₂ O, Li ₂ O and B ₂ O _{3 make} the glass low-melting, TiO ₂ , Al ₂ O ₃ , MgO, ZrO ₂
And CaF ₂ acts to regulate the apatite coating rate. These inorganic compounds can be contained in an amount of 0 to 30% by weight based on the whole bioactive glass.

The bioactive glass used in the present invention is spherical,
It has a bead shape, a granular shape, a granular shape, and the like, and can be produced based on a method disclosed in, for example, Japanese Patent Application Laid-Open No. 60-239341. Also, bioactive glass is
Those with less than 32 mesh passes are suitably used, with 65 mesh passes being particularly preferred. When the size is 32 mesh or more, the feeling of use of the oral composition is impaired, which is not preferable.

The oral composition of the present invention can be made into a dosage form such as toothpaste, toothpaste, gel, ointment, mouthwash, chewing gum, dental floss, patch or sealant by a conventional method. It is preferably used as a dentifrice or mouthwash because of its usability.

[0015] In addition to the above-mentioned bioactive glass, the oral composition of the present invention contains an abrasive, a foaming agent, a flavoring agent, a sweetening agent, a binder, a pH adjusting agent, a wetting agent according to the respective dosage form. A base such as an agent, and a medicinal component can be appropriately blended within a range that does not impair the effects of the present invention.

For example, in the case of a dentifrice, dibasic calcium phosphate dihydrate and anhydride, calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel are used as abrasives. , Aluminum silicate,
Insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resin, and the like can be used. These abrasives may be used alone or in combination of two or more.
Usually, it is 5 to 90% by weight based on the whole composition, and 5 to 60% by weight in the case of toothpaste.

The foaming agent mainly includes a nonionic surfactant and an anionic surfactant. Examples of the nonionic surfactant include a fatty acid ester of sugar or sugar alcohol. Respectively, the fatty acid residue has 12 to 18 carbon atoms, the average degree of esterification is 1.1 to 2.5,
Preferably, 1.2 to 1.9 can be used.
Examples of the fatty acid ester of the sugar or sugar alcohol include sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, maltotriitol fatty acid ester, maltotetriitol fatty acid ester, maltopentitol fatty acid ester, and maltohexayl fatty acid ester. Tall fatty acid esters, malt heptitol fatty acid esters, sorbitan fatty acid esters, lactose fatty acid esters, lactinose fatty acid esters, and the like.

Other nonionic surfactants include:
Polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene polyoxypropylene glycol ether, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, fatty acid monoglyceride, poly Oxyethylene higher alcohol ethers, polyoxyethylene polyoxypropylene fatty acid esters and the like can be mentioned.
In addition, these nonionic surfactants may be used alone or in combination of two or more, and the compounding amount is usually 0.001 to 40% by weight, preferably 0.001 to 40% by weight, based on the whole composition. It is 0.01 to 30% by weight.

Examples of the anionic surfactant include water-soluble salts of higher alkyl sulfates having an alkyl group having 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, α-olefin sulfonate salts, and the like. Higher fatty acid sodium monoglyceride monosulfate, N-methyl-N-palmitoyl tauride salt, N-long-chain acyl basic amino acid salt, and the like. These anionic surfactants can be used alone or in combination of two or more. They may be used in combination, usually in an amount of 0.001 to 10% by weight, preferably 0.1 to 10% by weight, based on the whole composition.
01 to 5% by weight.

Examples of the binder include cellulose derivatives such as carboxymethyl cellulose, alkali metal alginate such as sodium alginate, propylene glycol alginate, xanthan gum, gum tragacanth, gum karaya, gum arabic, gum gum such as carrageenan, polyvinyl alcohol, and polyacrylic acid. Sodium, carboxyvinyl polymer, synthetic binders such as polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, veegum, and laponite. These binders may be used alone or in combination of two or more. The amount may be usually 0.001 to 5% by weight based on the whole composition.

Further, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cionell, linalool,
Flavors of ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, diatom oil, perilla oil, winter green oil, clove oil, eucalyptus oil, etc. The agents may be used alone or in combination of two or more. The compounding amount is usually 0.01 to 10% by weight based on the whole composition,
Preferably it is 0.05 to 5% by weight.

In addition, sweeteners such as saccharin sodium, acetyl pharma potassium, stevioside, neohesporidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, aspartyl phenylalanine methyl ester, p-methoxycinnamic aldehyde and xylit are used alone. May be used in combination of two or more, and the compounding amount is usually 0.0 with respect to the whole composition.
1 to 5% by weight.

[0023] Further, dosage forms such as dentifrices or mouthwashes may include humectants such as sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, maltit, and lactit. The composition may be used alone or in combination of two or more kinds. The compounding amount is usually 1 to 70% by weight based on the whole composition.

Also, sodium hydrogen phosphate, citric acid,
PH adjusters such as sodium citrate, bactericides such as chlorhexidine gluconate, cetylpyridinium chloride, and triclosan; enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (Litec enzyme), and sodium monofluorophosphate , Alkali metal monofluorophosphates such as potassium monofluorophosphate, fluorides such as sodium fluoride and stannous fluoride, vitamin derivatives, tranexamic acid and epsilon aminocaproic acid, aluminum chlorhydroxyallantoin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetin Active ingredients such as acid, glycerophosphate, chlorophyll, sodium chloride, caropeptide, water-soluble inorganic phosphate compound,
They may be used alone or in combination of two or more.

[0025]

EXAMPLES Next, the present invention will be described more specifically with reference to examples and experimental examples, but the present invention is not limited to these examples. Unless otherwise specified, [%] indicates% by weight.

Examples and Comparative Examples (formulations in which hydroxyapatite was replaced with bioactive glass and formulations in which both components were not blended) were prepared by a conventional method and used for evaluation. Example 1 Toothpaste Ingredients Content (%) Calcium Carbonate 40.0 Sodium Carboxymethyl Cellulose 2.0 Sodium Benzoate 0.4 Sodium Saccharin 0.1 Sodium Lauryl Sulfate 1.2 Polyethylene Glycol 5.0 Fragrance 1.0 Water Suitable Amount Bioactive glass 5.0 (CaO / SiO ₂ / Na ₂ O; 30/45/25%) Total 100.0

Comparative Example 1 Toothpaste Component Content (%) Calcium Carbonate 40.0 Sodium Carboxymethyl Cellulose 2.0 Sodium Benzoate 0.4 Saccharin Sodium 0.1 Sodium Lauryl Sulfate 1.2 Polyethylene Glycol 5.0 Fragrance 1. 0 Appropriate amount of water Hydroxyapatite 5.0 Total 100.0

Evaluation A section of about 1 × 3 mm ² was prepared from enamel of adult permanent teeth. This section was embedded in an acrylic resin, brushed for 5 minutes using the toothpaste of Example 1 and a commercially available toothbrush, and then allowed to stand in whole saliva at 37 ° C. for 12 hours. When the adult permanent teeth were observed with a microradiograph, a hydroxyapatite film was uniformly formed on the surface of the enamel at about 5 μm.
It was recognized that a μm was formed. However, when the same operation was performed with the toothpaste of Comparative Example 1, it took 24 hours to form a hydroxyapatite film of about 5 μm, and the formulation of Example 1 except that bioactive glass was removed. When the same operation was performed with toothpaste, no hydroxyapatite film was formed on the enamel surface.

Example 2 Mouthwashing agent Ingredients Content (%) Glycerin 15.0 Alcohol 10.0 Polyoxyethylene (60) hydrogenated castor oil 0.5 Sodium citrate (pH adjuster) 0.05 Stevia 0.05 02 water q.s. bioactive glass _{5.0 (CaO / SiO 2 / Na} 2 O; 20/60/20%) total 100.0

Evaluation The mouthwash of Example 2 was added to the whole saliva so as to have a concentration of 1%, and left at 37 ° C. for 12 hours. As a result, crystals were precipitated in the liquid, and the crystals were analyzed by IR and X-ray diffraction. As a result, it was confirmed that the crystals were hydroxyapatite. However, when the same operation was performed using a mouthwash having the above-mentioned formulation except for the bioactive glass, no crystals were precipitated in the liquid.

Example 3 Toothpaste Ingredients Content (%) Silicic Anhydride 15.0 Sodium Carboxymethyl Cellulose 2.0 Plating Thickness 0.2 Sodium Saccharin 0.1 Sodium Lauryl Sulfate 1.2 Flavor 1.0 Water Appropriate Amount Bioactivity Glass 5.0 (CaO / SiO ₂ ; 50/50%) Total 100.0 Even with the toothpaste of Example 3, it was confirmed that a uniform hydroxyapatite film was formed on the tooth surface in a short time.

From these results, it was confirmed that the oral composition of the present invention formed a hydroxyapatite film on the tooth surface in a shorter time and more uniformly than the conventional oral composition.

[0033]

According to the present invention, there can be provided an oral composition effective for preventing dental caries, which forms a hydroxyapatite film on the enamel surface of teeth in a short time and uniformly.

Claims (7)

[Claims] An oral composition comprising one or more bioactive glasses. 2. The oral composition according to claim 1, wherein the bioactive glass comprises 10 to 70% by weight of SiO ₂ and 5 to 60% by weight of CaO. 3. The oral composition according to claim 1, wherein the bioactive glass comprises 10 to 60% by weight of SiO ₂ , 5 to 50% by weight of CaO, and 0 to 30% by weight of Na ₂ O. 4. The bioactive glass further comprises P ₂ O ₅ , K
₂ O, Li ₂ O, TiO ₂ , Al ₂ O ₃ , MgO, B ₂ O ₃ ,
ZrO _2, and claim 2 or 3 oral composition according to any one contain one or more inorganic compounds selected from the group consisting of CaF _2. 5. The oral composition according to claim 1, wherein the size of the bioactive glass is less than 32 mesh pass. 6. The oral composition according to claim 1, further comprising 0.001 to 50% by weight of a bioactive glass. 7. A dentifrice or mouthwash.
The oral composition according to any one of the preceding claims.