JPH1058610A - Antibacterial resin molding - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enhance safety for a human body by forming a hydrophilic coat on the surface of a resin molding with which an antibacterial agent is bonded and thereby minimizing the causes for rash or allergy through contact with the skin or mucosa. SOLUTION: A hydrophilic coat is formed on the surface of a resin molding with which an antibacterial agent is bonded. Therefore, the active group of the antibacterial agent which cause rash or allergy no longer comes into contact directly with the skin or mucosa. The hydrophilic coat is as thick as, for example, 10-2000nm. If this thickness is excessively small, the active group of the antibacterial agent easily comes into contact with an organism such as skin or mucosa and the coat is less durable. On the contrary, if the thickness is excessively large, bacteria hardly come into contact with the antibacterial agent, resulting in the deterioration of antibacterial performance. In addition, the transparency is deteriorated, so that this tendency is sometimes disadvantageous for this resin molding. Thus it is possible to obtain the highly safe antibacterial resin molding which hardly causes rash or allergy through contact with the skin or mucosa.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an antibacterial resin molded article. Furthermore, it relates to an antibacterial resin molded product that is safe for the human body.

[0002]

2. Description of the Related Art At present, many resin products having antibacterial properties are on the market. For household resin products, cutting boards and
Toothbrushes and the like (Japanese Patent Publication No. 63-54013, etc.), in which an antibacterial property is imparted to a resin part of an electric product
295127) and application to antibacterial fibers and the like (JP-A-5-310820). Also, antibacterial contact lenses (JP-A-4-76518, JP-A-5-765)
-269181, PCT / JP94 / 01149
There is also a medical device such as Japanese Patent Publication No. In addition, there is also an antibacterial film (Japanese Patent Publication No. 6-18898).

[0003]

The resin products provided with the antibacterial properties as described above have many opportunities to come into contact with the living body, so that sufficient consideration is required for safety. Above all, medical devices such as contact lenses and medical device components such as endoscopes are required to have high safety because they come into contact with living mucous membranes. Also,
Since antibacterial resin moldings such as contact lens-related resin products, baby products, and household plastic products such as thermometers are in contact with skin and mucous membranes, safety is important.

[0004] However, these antibacterial resin molded articles having antibacterial properties may cause rash and allergy when they come into contact with skin and mucous membranes, and these antibacterial resin molded articles do not always have sufficient safety for the human body. I couldn't say I had it.

Accordingly, the present invention has been made to solve such problems, and an object of the present invention is to provide a safer human body which is less likely to cause rash or allergy even when it comes into contact with skin or mucous membranes. An object of the present invention is to provide an antibacterial resin molded article having high property.

[0006]

Means for Solving the Problems The present inventors have conducted intensive studies on an antibacterial resin molded product, and as a result, have found that a hydrophilic film is formed on the surface of the resin molded product to which an antibacterial agent is bonded. The present inventors have found that the resin molded article is an antibacterial resin molded article which is less likely to cause rash or allergy even when it comes into contact with skin or mucous membranes and which is safer for the human body, and has completed the present invention.

That is, the antibacterial resin molded article of the present invention comprises:
It is characterized in that a hydrophilic film is formed on the surface of the resin molded body to which the antibacterial agent is bonded.

As described above, since the antibacterial resin molded article of the present invention has a hydrophilic film formed on the surface of the resin molded article to which the antibacterial agent is bonded, the activity of the antibacterial agent which causes rash and allergy is caused. The groups no longer come into direct contact with the skin and mucous membranes. As a result, the antibacterial resin molded article of the present invention is less likely to cause rash and allergy even when it comes into contact with skin and mucous membranes, and becomes an antibacterial resin molded article having higher safety for the human body.

This hydrophilic film has a thickness of 10 nm to 2 nm.
000 nm, preferably 100 nm to 100 nm.
More preferably, it is 0 nm. If the film thickness is too small, the living body such as skin and mucous membrane easily comes into direct contact with the active group of the antibacterial agent, and the durability of the film is undesirably reduced.
If the film thickness is too large, bacteria are less likely to come into contact with the antibacterial agent and the antibacterial performance is reduced, which is not preferable. Further, there are cases where the transparency is impaired, which is not preferable.

The hydrophilic film is preferably formed by graft polymerization of a hydrophilic monomer. The reason why the hydrophilic monomer is polymerized is that it is well compatible with tears and mucus. In addition, the graft polymerization is performed because a polymer film having an appropriate gap, easily allowing bacteria to pass through, and not deteriorating the antibacterial effect can be obtained. In addition, compared to a film in which only a hydrophilic monomer is applied and a polymer film in which a hydrophilic monomer is applied and then polymerized, the graft polymer film is chemically bonded to the surface of the resin molded body more strongly. This is because a polymer film having sufficient durability can be formed.

The graft polymerization is carried out by irradiating the surface of the antibacterial resin molded article with ultraviolet rays, corona discharge or low-temperature plasma discharge, gamma ray irradiation, etc., and graft-polymerizing monomers to the generated radicals. For example, a method of subjecting an antibacterial resin molded body to plasma treatment of a lens by glow discharge under a reduced pressure of 10 ⁻³ to 10 torr, introducing monomers as vapor or liquid into the apparatus, and directly reacting with radicals, or after a low-temperature plasma treatment And a method in which the substrate to be treated is removed from the apparatus and reacted with the monomer.

In the graft polymerization, a compound having a hydrophilic property, such as a vinyl group, an allyl group, an acryl group, or a methacryl group, which is generally used in the molecule, may be used. Hydrophilic monomers can be used.

The hydrophilic monomers include methacrylic acid, acrylic acid, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, fumaric acid, maleic acid, itaconic acid, acrylamide, N, N- It is preferably at least one hydrophilic monomer selected from the group consisting of dimethylacrylamide and N-vinyl-2-pyrrolidone.

Specific examples thereof include hydroxyalkyl methacrylate, hydroxyalkyl acrylate, polyethylene glycol methacrylate, polyethylene glycol acrylate, and polyhydric alcohol (meth) acrylate.

More specifically, for example, (meth) acrylic acid, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, fumaric acid, maleic acid, itaconic acid, acrylamide, N, N-dimethylacrylamide, N-vinyl-2-pyrrolidone and the like can be mentioned.

There is also a method of obtaining a hydrophilic graft layer by graft-polymerizing an ester of an organic acid in the above compound without directly grafting a hydrophilic monomer, and then hydrolyzing them.

Further, in order to increase the crosslink density of the graft membrane and improve the durability, ethylene glycol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, 1,6-hexanediol diacrylate, ethylene glycol dimethacrylate, Diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, propylene glycol dimethacrylate, trimethylolpropane trimethacrylate, pentaerythritol triacrylate, 1,4-butanediol dimethacrylate, 1,6
-Hexanediol dimethacrylate, glycerin dimethacrylate, divinylbenzene diallyl phthalate,
It is preferable to improve durability by using a polyfunctional monomer such as diethylene glycol bisallyl carbonate and ethylene bisacrylamide.

The graft polymerization of the present invention is carried out by heating or irradiation with active energy rays such as ultraviolet rays in the presence of a usual polymerization initiator.

As a specific polymerization initiator, a radical polymerization initiator is desirable, for example, benzoyl peroxide, diisopropylperoxydicarbonate, t-butylperoxy-2-ethylhexanoate, t-butylperoxypiate. Valate, t-butyl peroxydiisobutyrate, t-butyl peroxyisopropyl carbonate, lauroyl peroxide, azobisisobutyronitrile, azobis (2,4-dimethylvaleronitrile) and the like are used. Further, a redox method using Mohr salt or the like can also be used.

In the case of irradiation with an active energy ray, a photopolymerization initiator such as benzoin ether or a sensitizer is used if necessary. The amount of these initiators used is preferably 0.001 to 2% by weight based on the monomers used.

Antibacterial agents which can be bonded to the antibacterial resin molded product include antibacterial metal antibacterial agents, biguanide antibacterial agents, quaternary ammonium salts, quaternary phosphonium salts,
One or more antibacterial agents selected from the group consisting of chitosan and acridine antibacterial agents can be used.

The antibacterial resin molded article of the present invention comprises a medical device,
Suitable for medical device parts or household resin products, especially contact lenses, contact lens storage containers, contact lens preservative containers, contact lens cleaning agent containers, contact lens-related resin products, endoscope coating films and eyes Ideal for pressure measurement device eyepiece.

Further, the present invention is not limited to the above products, but also includes cooking utensils such as cutting boards, tableware such as plastic chopsticks and bowls,
Baby goods such as toys and baby bottles, ornaments such as piercings,
It can be widely applied to products that may come into direct contact with living bodies, such as automatic thermometers, bathtubs, toilets, antibacterial wallpapers, and the like.

[0024]

The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the present invention is limited thereto.

1. Preparation of hydrophilic monomer-grafted antibacterial resin molded article (Sample 1) (1) Preparation of antibacterial contact lens N, N-dimethylacrylamide 45% by weight, 2,2,2
30% by weight of 2-trifluoroethyl methacrylate, 18% by weight of tris (trimethylsiloxy) silylpropyl methacrylate, 5% by weight of trioctyl methacrylphosphonium chloride, 0.7% by weight of ethylene glycol dimethacrylate, 2,2′-azobis (2, 0.3% by weight of 4-dimethylvaleronitrile) was mixed well at room temperature. This mixture was poured into a glass test tube, the inside of which was replaced with nitrogen, and then sealed. The test tube was immersed in a hot water bath controlled by a program controller for 6 hours at 28 ° C, 4 hours at 30 ° C, 3 hours at 32 ° C, 2 hours at 40 ° C, 2 hours at 50 ° C, and 1 hour at 60 ° C. 2.5 hours at 80 ° C.
Then, the mixture was heated at 105 ° C. for 2 hours in an air furnace to carry out polymerization. A round bar of the obtained copolymer was cut, cut and polished to obtain a contact lens.

(2) Plasma treatment: Next, the contact lens was vacuumed in a plasma polymerization apparatus at a pressure of 0.1 torr.
Low-temperature plasma treatment at a discharge frequency of 13.56 MHz and a discharge power of 50 W for 15 minutes in an oxygen atmosphere.

(3) Graft polymerization: acrylamide 7
A contact lens treated with plasma in (2) is immersed in 3 ml of an aqueous solution of 0% by weight, 10% by weight of methylenebisacrylamide and 1.6% by weight of Mohr salt, quickly degassed, sealed, and graft-polymerized at 40 ° C. for 10 minutes. Was done.

The lens was swollen in pure water, washed, and then immersed in a physiological saline to absorb a predetermined amount of water and complete elution of the eluted material.

(Sample 2) (1) Polymerization, cutting and polishing of contact lenses: Tris (trimethylsiloxy) silylpropyl methacrylate 30% by weight, methyl methacrylate 30% by weight, isopropyl heptadecafluoromethacrylate 25% by weight,
Trioctyl allyl phosphonium chloride 5% by weight,
5% by weight of methacrylic acid, 4% by weight of allyl methacrylate, t-butyl peroxyisopropyl carbonate 1
% By weight, the mixture was placed in a glass sealed tube, the inside of which was replaced with nitrogen, degassed repeatedly, and sealed under vacuum. The sealed tube is heated at 30 ° C. for 10 hours in hot water and 5 hours at 40 ° C.
The mixture was heated at 50 ° C. for 5 hours, at 60 ° C. for 3 hours, at 70 ° C. for 3 hours, and further heated at 100 ° C. for 2 hours in an air furnace to carry out polymerization to obtain a round bar. The obtained rod was cut to obtain a contact lens.

(2) Binding of chitosan to contact lens: The prepared contact lens was immersed in a solution of chitosan in N-methylpyrrolidone, treated with sodium hydroxide, and treated with dimethylformamide to crosslink.

(Sample 3) (1) Polymerization, cutting and polishing of contact lens: 92.7% by weight of 2-hydroxyethyl methacrylate, 2% by weight of ethylene glycol dimethacrylate, 5% by weight of vinyl chlorhexidine, 0% of diisopropyloxy dipercarbonate 0.3% by weight, the mixture was placed in a glass sealed tube, the inside of which was replaced with nitrogen and degassed repeatedly, and sealed under vacuum. The sealed tube is heated at 30 ° C. for 10 hours in hot water,
5 hours at 40 ° C., 5 hours at 50 ° C., 3 hours at 60 ° C., 7
The mixture was heated at 0 ° C. for 3 hours and further heated at 100 ° C. for 2 hours in an air furnace to carry out polymerization to obtain a round bar. The obtained rod was cut to obtain a contact lens.

(2) Corona: Corona discharge was performed on the antibacterial resin at 12 KV for 5 minutes for each of the FC surface and the BC surface.

(3) Graft polymerization: The obtained contact lens was immersed in acrylic acid, degassed, and graft-polymerized at 40 ° C. for 30 minutes. Swell this lens in pure water,
After washing, the sample was immersed in a physiological saline to absorb a predetermined amount of water, and at the same time, elution of the eluate was completed.

(Sample 4) (1) Polymerization, cutting and polishing of contact lenses: 2, 3
68.95% by weight of dihydroxypropyl methacrylate, 26% by weight of methyl methacrylate, 1% by weight of ethylene glycol dimethacrylate, vinylbenzethonium 4
% By weight and 2,4,6-trimethylbenzoyldiphenylphosphine oxide (0.05% by weight) were mixed well, and the mixture was degassed and purged with nitrogen. This mixture was dropped into a resin (plastic) mold formed into a contact lens shape, and the mixture was irradiated with ultraviolet rays at a distance of 10 cm for 100 seconds using an 80 W / cm high pressure mercury lamp.

(2) Plasma treatment: Next, this contact lens is placed in a plasma polymerization apparatus at a degree of vacuum of 0.1 ton.
A low-temperature plasma treatment was performed for 30 seconds at a discharge frequency of 13.56 MHz and a discharge power of 200 W in an air atmosphere of rr.

(3) Graft polymerization: A contact lens treated with plasma in (2) was immersed in 3 ml of a benzene solution of 10% by weight of dimethylacrylamide and 5% by weight of ethylene glycol dimethacrylate, quickly degassed, and then sealed. The graft polymerization treatment was performed for 5 minutes.

(4) Extraction: The lens was swollen in pure water, washed, and immersed in a physiological saline solution to absorb a predetermined amount of water, and at the same time complete elution of the eluate.

(Sample 5) (1) Preparation of antibacterial contact lens 2-hydroxyethyl methacrylate 87.7% by weight,
2% by weight of ethylene glycol dimethacrylate, 10% by weight of trioctyl methacryl phosphonium chloride,
0.3% by weight of 2,2′-azobis (2,4-dimethylvaleronitrile) was mixed well at room temperature. This mixture was poured into a glass test tube, the inside of which was replaced with nitrogen, and then sealed. The test tube was immersed in a hot water bath controlled by a program controller for 6 hours at 28 ° C, 4 hours at 30 ° C, 3 hours at 32 ° C, 2 hours at 40 ° C, 2 hours at 50 ° C, and 1 hour at 60 ° C. The mixture was heated at 80 ° C. for 2 hours and further heated at 105 ° C. for 2 hours in an air furnace to conduct polymerization. A round bar of the obtained copolymer was cut, cut and polished to obtain a contact lens.

(2) Plasma treatment: Next, the contact lens was vacuumed at 0.1 torr in a plasma polymerization apparatus.
Low-temperature plasma treatment at a discharge frequency of 13.56 MHz and a discharge power of 50 W for 15 minutes in an oxygen atmosphere.

(3) Graft polymerization: N-vinyl-2-
After immersing the contact lens treated with plasma in (2) in 3 ml of pyrrolidone, quickly evacuating and sealing, then at 40 ° C. for 10 minutes
The graft polymerization treatment was performed for 5 minutes.

The lens was swollen in pure water, washed, and then immersed in a physiological saline to absorb a predetermined amount of water, and at the same time complete elution of the eluate.

(Sample 6) (1) Polymerization, cutting and polishing of contact lenses: 91.7% by weight of 2-hydroxyethyl methacrylate, 2% by weight of ethylene glycol dimethacrylate, 5% by weight of trioctyl allyl phosphonium chloride, 2,2 0.3% by weight of '-azobis (2,4-dimethylvaleronitrile) was mixed well, and the mixture was placed in a glass sealed tube, the inside of which was replaced with nitrogen and degassed repeatedly, and sealed under vacuum. This sealed tube is heated at 30 ° C for 10 hours in warm water, 5 hours at 40 ° C, and
The mixture was heated at 0 ° C. for 5 hours, at 60 ° C. for 3 hours, at 70 ° C. for 3 hours, and further heated at 100 ° C. for 2 hours in an air furnace to carry out polymerization to obtain a round bar. The obtained rod was cut to obtain a contact lens.

(2) Graft polymerization of hydrophilic monomer by ultraviolet rays: 0.2 mol / l of the obtained contact lens
It is immersed in a benzene solution containing benzophenone and 0.5 mol / l N, N-dimethylacrylamide.
The surface of the contact lens was graft-polymerized with a hydrophilic monomer.

(3) Extraction: The lens was swollen in pure water, washed and then immersed in a physiological saline solution to absorb a predetermined amount of water, and at the same time complete elution of the eluted material.

(Sample 7) (1) Preparation of antibacterial resin: 90% by weight of acrylic acid and 10% by weight of silver vinylbenzoylacetonate were mixed well, and the mixture was placed in a glass sealed tube. The air was repeatedly sealed under vacuum. Place the sealed tube in hot water at 30 ° C.
10 hours, 40 ° C for 5 hours, 50 ° C for 5 hours, 60 ° C
For 3 hours and at 70 ° C for 3 hours.
Polymerization was performed by heating at 2 ° C. for 2 hours to obtain a round bar. This round bar was pulverized, and a polystyrene resin was injection molded to prepare a contact lens bottle.

(2) Corona: Corona discharge was applied to the contact lens bottle at 12 KV for 5 minutes each.

(3) Graft polymerization: acrylamide 7
A contact lens bottle plasma-treated in (2) is immersed in 3 ml of an aqueous solution of 0% by weight, 10% by weight of methylenebisacrylamide and 1.6% by weight of Mohr salt, quickly degassed, sealed, and graft-polymerized at 40 ° C. for 10 minutes. Processing was performed.

(Sample 8) (1) Preparation of antibacterial resin: 90% by weight of acrylic acid and 10% by weight of trioctylallylphosphonium chloride were mixed well, and the mixture was placed in a glass sealed tube. The air was repeatedly sealed under vacuum. This sealed tube,
10 hours at 30 ° C, 5 hours at 40 ° C, 5 hours at 50 ° C
The mixture was heated at 60 ° C. for 3 hours, at 70 ° C. for 3 hours, and further heated at 100 ° C. for 2 hours in an air furnace to carry out polymerization to obtain a round bar. This round bar was pulverized, and a polyethylene resin was injection-molded according to a conventional method to prepare an antibacterial thin film.

(2) Corona: Corona discharge was performed on the antibacterial thin film at 12 KV for 5 minutes each.

(3) Graft polymerization: acrylamide 7
0% by weight, 10% by weight of methylenebisacrylamide, 1.6% by weight of Mohr salt, 3 ml of the plasma-treated thin film was immersed, quickly degassed, sealed, and heated at 40 ° C. for 1 hour.
Graft polymerization treatment was performed for 0 minutes. This thin film was used as an endoscope coating film having antibacterial properties.

(Sample 9) (1) Plasma treatment: A resin plate (3 cm × 3 cm) of Bactekiller MB (manufactured by Kanebo Co., Ltd., kneaded with 2% silver zeolite in polypropylene) was vacuumed to a degree of 0.degree.
Discharge frequency 13.56M in an oxygen atmosphere of 01 torr
Low-temperature plasma treatment at 50 Hz for 30 minutes at a discharge power of 50 Hz.

(2) Graft polymerization: acrylamide 7
A resin plate treated with plasma in (2) is immersed in 3 ml of an aqueous solution of 0% by weight, 10% by weight of methylenebisacrylamide and 1.6% by weight of Mohr salt, quickly degassed, sealed, and graft-polymerized at 40 ° C. for 10 minutes. Was done. By cutting the resin prepared by this method, a resin part of the tonometer was prepared.

2. Evaluation of antimicrobial activity Bacteria count method. The following operations were all performed aseptically.

B. Culture of fungi:
Passage at least 3 passages at 37 ° C. for 16 to 24 hours in a slant medium, transplant into 8 to 10 ml of broth, 37 ° C., 16 to 24
Cultivate for a time to obtain a bacterial solution. This bacterium is stored at 15 ° C.
Used within days.

B. Test bacteria: Escherichia coli
i) and Staphylococcus aureus ATCC
6538P) C. Evaluation of antibacterial activity: Each of the bacteria was prepared using a common broth medium so that the number of bacteria per ml was 10 ^{3 to} 3.0 × 10 ⁶ . Each of the samples 1 to 7 sterilized by ultraviolet light was immersed in 1 ml of a bacterial solution prepared with the above two types of bacteria,
Stored at 37 ° C. Immediately before the start of storage (0 hr) and 0.5, 1.0, and 2.0 hours after the start of storage, the number of remaining bacteria in each culture was determined, and the antibacterial activity was evaluated. The number of bacteria in the culture solution was determined by diluting each culture solution with sterile physiological saline, and then pour plate culture medium (manufactured by Eiken Chemical Co., Ltd., standard agar medium) (37 plates).
C. for 2 days), the number of colonies of the bacteria appearing was measured and determined.

[0056]

[Table 1]

[0057]

[Table 2]

[0058]

[Table 3]

[0059]

[Table 4]

[0060]

[Table 5]

[0061]

[Table 6]

[0062]

[Table 7]

[0063]

[Table 8]

[0064]

[Table 9]

The results of evaluation of the antibacterial activity of the antibacterial resin molded article by the above method are shown in the table. In the table, "Control" indicates an antibacterial resin molded product not subjected to graft polymerization of a hydrophilic monomer.

3. Safety Evaluation The above samples 1 to 6 and control samples 1 to 6 not treated with graft polymerization were respectively attached to rabbit eyes, and were followed for 7 days. Thereafter, the safety of the antimicrobial contact lens was evaluated pathologically according to the method described in ISO 9394.

Sample 1 grafted with a hydrophilic monomer
In any of the samples No. to No. 6, no difference from the non-wearing eye was recognized. On the other hand, control samples 1 to which no graft polymerization of a hydrophilic monomer was performed
In No. 6, weak toxicity such as eye oil and conjunctival hyperemia was observed.

For the samples 7 to 9 and the control samples 7 to 9 not treated with the graft polymerization, respectively, primary skin irritation tests (based on Federal Register) using rabbits were performed.
The cornified layer of the rabbit was scratched, and the sample was contacted and observed for 4, 24, 48 and 96 hours.

[0069] As a result, weak erythema was observed in the control sample, whereas no skin irritation was observed in the treated sample.

Continued on the front page (51) Int.Cl. ⁶ Identification code Reference number in the agency FI Technical display location A01N 47/44 A01N 47/44 57/34 57/34 59/16 59/16 A A61L 31/00 A61L 31 / 00 Z B29D 11/00 B29D 11/00 C08J 7/04 C08J 7/04 T C08L 51/00 LLV C08L 51/00 LLV LLW LLW G02B 1/10 G02C 7/04 G02C 7/04 G02B 1/10 Z

Claims (10)

[Claims] 1. An antibacterial resin molded article characterized in that a hydrophilic film is formed on the surface of a resin molded article to which an antibacterial agent is bonded. 2. The antibacterial resin molded product according to claim 1, wherein the hydrophilic film has a thickness of 10 nm to 2000 nm. 3. The antibacterial resin molded product according to claim 1, wherein the hydrophilic film is a hydrophilic film formed by graft-polymerizing a hydrophilic monomer. Molded body. 4. The antibacterial resin molded product according to claim 3, wherein the hydrophilic monomer is methacrylic acid, acrylic acid, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, hydroxybutyl methacrylate, fumaric acid. An antimicrobial resin molded article characterized in that it is at least one hydrophilic monomer selected from the group consisting of acid, maleic acid, itaconic acid, acrylamide, N, N-dimethylacrylamide and N-vinyl-2-pyrrolidone . 5. The antibacterial resin molded product according to claim 1, wherein the antibacterial agent is an antibacterial metal antibacterial agent, a biguanide antibacterial agent, a quaternary ammonium salt, An antibacterial resin molded product, which is one or more antibacterial agents selected from the group consisting of quaternary phosphonium salts, chitosan and acridine antibacterial agents. 6. The antibacterial resin molded product according to any one of claims 1 to 5, wherein the antibacterial resin molded product is a medical device, a component of a medical device, or a household resin product. Characterized antibacterial resin molding. 7. The antibacterial resin molded product according to claim 6, wherein the antibacterial resin molded product is a contact lens. 8. The antibacterial resin molded product according to claim 6, wherein the antibacterial resin molded product is a contact lens storage container,
An antibacterial resin molded product, which is a contact lens preservative container, a contact lens detergent container or a contact lens-related resin product. 9. The antibacterial resin molded product according to claim 6, wherein the antibacterial resin molded product is an endoscope coating film. 10. The antibacterial resin molded product according to claim 6, wherein the antibacterial resin molded product is an eyepiece of an intraocular pressure measuring device.