JPH1053747A - Pressure-sensitive adhesive sheet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To inexpensively prevent a pressure-sensitive adhesive sheet from adhering to the inner surface of a packaging material to thereby enable the sheet to be easily pulled out for use. SOLUTION: A pressure-sensitive adhesive layer 4 is formed on the surface of a separator 5 which comprises a plastic sheet, etc., and of which the surface has been treated so as to be readily peeled from the adhesive layer 4. On the layer 4 is superposed a woven fabric 3 (roughness-forming member) having a reticular structure comprising interlaced threads made of any of various plastics or cotton and having openings 13 at regular intervals. A sheet-form or filmy support 2 is superposed on the fabric 3, thus giving the objective pressure-sensitive sheet 1 in which the back side of the support 2 has a roughness with the height of 130μm to 1mm.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a pressure-sensitive adhesive sheet. Specifically, the present invention relates to a structure of a pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer formed on a support.

[0002]

2. Description of the Related Art In recent years, as a means for administering a drug into a living body, a transdermal absorption method in which a pressure-sensitive adhesive sheet containing the drug is attached to the skin has been adopted. In such a drug-containing pressure-sensitive adhesive sheet, a pressure-sensitive adhesive layer containing a transdermal drug is laminated on one surface of a plastic support such as polyester or polyethylene, and the exposed surface of the pressure-sensitive adhesive layer is separated by a separator. Coated. The drug-containing pressure-sensitive adhesive sheet is usually individually wrapped with a moisture-impermeable wrapping material in order to prevent the contained transdermally absorbable drug from volatilizing and to prevent influence on humidity.

However, in the drug-containing pressure-sensitive adhesive sheets individually packaged as described above, the pressure-sensitive adhesive protrudes from the end face of the drug-containing pressure-sensitive adhesive sheet and adheres to the inner surface of the packaging material, or the pressure-sensitive adhesive on the back surface of the support. In some cases, it may be difficult to remove the drug-containing pressure-sensitive adhesive sheet during use.

[0004] In particular, when a plasticizer, a tackifier, a liquid component, and the like are contained in the pressure-sensitive adhesive layer, these substances ooze out from the end face of the pressure-sensitive adhesive layer, and the back surface of the support or the separator, Furthermore, it adheres (wraps around) to the inner surface of the packaging material,
As a result, there is a problem that the drug-containing sheet is stuck to the inner surface of the packaging material, making it difficult to remove the drug-containing pressure-sensitive adhesive sheet.

As a method of solving these problems, for example, a method of enlarging the size of the separator and providing a protruding portion, a so-called embankment, on the outer peripheral edge of the separator which has been made larger can be considered.

However, if the above-mentioned method of enlarging the separator is used, it is possible to prevent the sticking-out of the adhesive and the adhesion (wrap-in) of the plasticizer or the like to the back surface of the separator, but it is possible to prevent the adhesion (wrap-in) to the support. could not.

Although a method of providing a so-called embankment is a very effective method, the yield is lowered because the release paper used in the manufacturing process becomes large, and a protrusion is provided on the outer peripheral edge of the separator. As a result, a special device is required, resulting in a problem that the manufacturing cost is increased.

The present invention has been made in view of the above-mentioned drawbacks of the prior art, and has as its object to prevent the sticking of the adhesive sheet to the inner surface of the packaging material by an inexpensive method, and An object of the present invention is to make it possible to take out the containing adhesive sheet extremely easily.

[0009]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to achieve the above object, and as a result, have found that a net-like woven or knitted fabric is interposed between a support and an adhesive layer containing a drug. By sandwiching the cloth and forming irregularities on the surface of the support opposite to the pressure-sensitive adhesive layer side, the substantial contact area between the drug-containing pressure-sensitive adhesive sheet and the inner surface of the packaging material is reduced, and the sticking of the drug-containing pressure-sensitive adhesive sheet is reduced. They have found that they can be effectively prevented, and have completed the present invention.

[0010] The pressure-sensitive adhesive sheet of the present invention is a pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer formed on a support, wherein an uneven forming member is sandwiched between the support and the pressure-sensitive adhesive layer, and a high surface is provided on the back surface of the support. Is characterized by forming irregularities of 130 μm to 1 mm.

At this time, the total plane area of the projections of the unevenness formed on the back surface of the support is 5 to 40% of the total plane area of the back surface of the support.
It is preferred that

As the unevenness forming member for forming the unevenness, for example, a net-shaped woven fabric or knitted fabric having a large number of openings can be used. It is preferable to use one having a length of 1 mm to 20 mm.

The pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet can contain a transdermally absorbable drug.

[0014]

DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG. 1 is a perspective view showing a pressure-sensitive adhesive sheet 1 according to one embodiment of the present invention, partially cut away from a support, FIG. 2 is a perspective view showing the pressure-sensitive adhesive sheet 1 from a separator 5 side,
3 is a cross-sectional view taken along line AA ′ of FIG. 1, FIG. 4 is a perspective view showing a state in which the adhesive sheet 1 is wrapped with a packaging material 6, and FIG. 5 shows the adhesive sheet 1 wrapped with the packaging material 6. It is sectional drawing. The details will be described below with reference to the drawings.

The pressure-sensitive adhesive sheet 1 is formed by laminating a woven or knitted fabric 3 on a sheet-like or film-like support 2 as an uneven forming member for forming unevenness on the back surface of the support 2. An adhesive layer 4 is laminated such that the knitted fabric 3 is sandwiched between the support 2 and the adhesive layer 4. Further, on the laminated adhesive layer 4, a surface of the adhesive layer 4 such as a plastic sheet or paper is provided. The separators 5 subjected to the easy peeling treatment are laminated. On the back surface of the support 2 of the adhesive sheet 1,
A large number of concave portions 11 are formed in the vertical and horizontal directions, and have an uneven shape.

The support 2 is made of various plastics or non-woven fabrics such as polyethylene and polyester, or a composite sheet obtained by laminating them, and in particular, does not transmit the transdermally-absorbed drug contained in the adhesive layer 4. Those made from materials are desirable. The thickness of the support 2 is 2 μm
A thickness of about 10 to 10 μm is desirable. If the thickness is less than 2 μm, the work of bonding the support 2 becomes difficult, and a strength problem such as a breakage occurs immediately. Also, 10 μm
If it is thicker, sufficient unevenness is not formed on the back surface of the support 2 by the laminated woven or knitted fabric 3.

The pressure-sensitive adhesive layer 4 contains a polymer pressure-sensitive adhesive such as acrylic, rubber, silicone or vinyl ether as a main component, and various transdermal drugs are mixed in the pressure-sensitive adhesive layer 4. Any transdermally absorbable drug can be used without particular limitation as long as it has percutaneous absorbability regardless of whether it is a systemic drug or a topical drug, for example, a general anesthetic, a hypnotic / sedative, an antiepileptic drug , Antipyretic analgesics and anti-inflammatory drugs, analgesics, psychiatric drugs, skeletal muscle relaxants, autonomic drugs, antispasmodics, antiparkinson drugs, antihistamines, inotropic drugs, arrhythmia drugs, diuretics, antihypertensive drugs, blood vessels Vasoconstrictors, coronary vasodilators, peripheral vasodilators, arteriosclerosis drugs, cardiovascular drugs, respiratory stimulants, antitussive expectorants, hormonal drugs, topical drugs for suppurative diseases, drugs for analgesic, antipruritic, astringent, antiphlogistic, Drugs for parasitic skin diseases, drugs for hemostasis, drugs for gout treatment, drugs for diabetes, drugs for antineoplastic tumors, antibiotics, chemotherapeutics, narcotics and the like can be used.

Various additives can be added to the pressure-sensitive adhesive layer 4, and a percutaneous absorption enhancer and other additives such as a plasticizer and a tackifier can be used. As a transdermal absorption enhancer, as a compound that mainly enhances drug solubility, glycols such as diethylene glycol, propylene glycol, and polyethylene glycol, and mainly as a compound that enhances drug diffusibility, oils and fats such as olive oil, squalene, and lanolin, and keratin Urea derivatives such as urea and allantoin as compounds that increase the water retention capacity of urea, dimethyldecylphosphoxide, methyloctyl sulfoxide, mainly as compounds that enhance keratin permeability,
Polar solvents such as dimethyllaurylamide, dodecylpyrrolidone, isosorbitol, dimethylacetamide, dimethylsulfoxide, dimethylformamide, salicylic acid that mainly enhances keratin softening, amino acids mainly as penetration aids, mainly as pore opening agents Benzyl nicotinate,
Examples thereof include sodium lauryl sulfate having a function of mainly changing the interface state of the skin and salocol used in combination with a drug having good transdermal absorbability.

Other plasticizers such as diisopropyl adipate, phthalate and diethyl sebacate, hydrocarbons such as liquid paraffin, various emulsifiers, ethoxylated stearyl alcohol, oleic acid monoglyceride,
Glycerin monoesters such as caprylic acid monoglyceride and lauric acid monoglyceride, or glycerin diester, glycerin triester or mixtures thereof, higher fatty acid esters such as isopropyl myristate and octyl palmitate, and higher grades such as oleic acid and caprylic acid Fatty acids and the like can be added. Particularly, in the present invention, the effect is exhibited particularly when a plasticizer such as diisopropyl adipate, a tackifier such as rosin, or a liquid component such as diethylene glycol or olive oil is blended.

The woven or knitted fabric 3 is not particularly limited in terms of material. For example, various plastic threads such as polyethylene and polyester or threads such as cotton threads are woven or knitted vertically and horizontally. It has a net shape, and a large number of openings 13 are preferably provided in the vertical and horizontal directions at a constant interval (pitch).

The thickness of the woven or knitted fabric 3 depends on the thickness of the pressure-sensitive adhesive layer 4, but is
It is sufficient that the thickness is such that irregularities of μm to 1 mm can be formed. For example, a general thickness of 70 μm to 120 μm
Woven or knitted fabric 3 has a thickness of 20
It is desirable that the thickness be 0 μm to 350 μm. If the thickness of the woven or knitted fabric 3 is less than 200 μm, sufficient irregularities are not formed on the back surface of the support 2, and if the thickness is more than 350 μm, the pressure-sensitive adhesive is sufficiently removed from the opening 13 of the woven or knitted fabric 3. This may make it difficult to cleanly adhere the support 2 to the pressure-sensitive adhesive layer 4 or may impair the flexibility of the pressure-sensitive adhesive sheet 1.

The size of the opening 13 of the woven or knitted fabric 3 is preferably 0.1 mm to 20 mm. When the size of the opening 13 is larger than 20 mm, the area of the concave portion 11 formed on the surface of the support 2 increases,
Actually, the concave portion 11 cannot be maintained, and the contact area with the inner surface of the packaging material 6 for wrapping the adhesive sheet 1 increases. As a result, the pressure-sensitive adhesive sheet 1 easily adheres to the inner surface of the packaging material 6, and the pressure-sensitive adhesive sheet 1 is difficult to remove from the packaging material 6. When the size of the opening 13 is smaller than 0.1 mm, the adhesive does not sufficiently exude from the opening 13 of the woven or knitted fabric 3, so that it is difficult to bond the support 2 neatly, Production of the sheet 1 becomes difficult. If the pressure-sensitive adhesive does not sufficiently exude from the opening 13, a pressure-sensitive adhesive layer may be separately formed on the support surface in advance, or an adhesive may be applied and bonded.

The convex portion 12 formed on the back surface of the support 2
, That is, the height from the bottom surface of the concave portion 11 on the back surface of the support 2 to the top of the convex portion 12 is set to 130 μm to 1 mm.
If it is less than 130 μm, the effect of the unevenness can hardly be exhibited, and if it is higher than 1 mm, the thickness of the woven or knitted fabric 3 must be increased, and therefore the thickness of the pressure-sensitive adhesive layer 4 needs to be increased. Not economic.

In the pressure-sensitive adhesive sheet 1, the area of contact with the inner surface of the packaging material 6 is determined by the projections 12 formed on the back surface of the support 2. The area occupied by the convex portion 12 with respect to the back surface of the support 2 varies depending on the type and composition of the pressure-sensitive adhesive to be used. Is preferably about 5 to 40% of the plane area of the back surface of the support 2. When the plane area of the convex portion 12 is less than 5%, the concave portion 11 formed on the back surface of the support 2 comes into contact with the inner surface of the packaging material 6,
As a result, it becomes difficult to remove the adhesive sheet 1 from the packaging material 6. On the other hand, if it exceeds 40%, the adhesive becomes woven or knitted.
Does not sufficiently exude from the opening 13 of the support member 2, it becomes difficult to bond the support 2 neatly. Here, the plane area of the convex portion 12 specifically refers to an area excluding the bottom surface portion of the concave portion 11, and the ratio of this area is specifically the thickness of the woven fabric or knitted fabric 3, that is, the woven fabric. Alternatively, it is determined by the thickness (diameter) of the yarn used for the knitted fabric 3, the size of the opening 13, the thickness of the pressure-sensitive adhesive layer 4, and the like. Therefore, an appropriate woven or knitted fabric 3 may be used depending on the type of the adhesive.

The total plane area of the projection 12 can be obtained in various ways, for example, as follows. An oily paint or paint is applied to the back surface of the support 2 of the adhesive sheet 1 cut to a certain size, and then transferred to white paper. At this time, on the white paper, the paint is transferred to the area corresponding to the convex portion 12 on the back surface of the support 2, and the area corresponding to the concave portion 11 remains white. By calculating the area on which the paint is transferred, the convex portion 1 is obtained.
2 or the area of the white region corresponding to the concave portion 11, and then the remaining area can be obtained as the total planar area of the convex portion 12. Of course, the area where the paint is transferred or the area of the white area where the paint is not transferred can be obtained by various methods, but generally, the paint is transferred in a substantially circular or annular shape. Many can be calculated as approximately the area of a circle.

The material of the separator 5 is not particularly limited, but a material corresponding to the pressure-sensitive adhesive layer 4 is selected. For example, a plastic or paper sheet or film having an easily peelable surface. Are used.
Of course, depending on the type of the adhesive, the easy peeling treatment may not be necessary.

In order to manufacture the pressure-sensitive adhesive sheet 1, first, a pressure-sensitive adhesive mixed with a percutaneous absorption drug, a percutaneous absorption accelerator, a plasticizer, etc., is coated on a readily peelable surface of the separator 5 by a general pressure-sensitive adhesive tape. The adhesive layer 4 is formed to a predetermined thickness by applying using a coating machine for manufacturing. Next, the woven or knitted fabric 3 is bonded on the pressure-sensitive adhesive layer 4, the support 2 is further stacked thereon, and bonded to each other with an appropriate pressure. The adhesive enters, and the adhesive oozes out between the woven or knitted fabric 3 and the support 2 to form irregularities on the back surface of the support 2, and the adhesive layer 4 and the woven or The knitted fabric 3 and the support 2 are bonded to the separator 5, and the pressure-sensitive adhesive sheet 1 of the present invention can be manufactured.

The pressure-sensitive adhesive sheet 1 thus produced is shown in FIG.
As shown in (1), one or several adhesive sheets 1 are stacked and wrapped with a packaging material 6, and the packaging material 6 is heat-sealed and sealed. The packaging material 6 is not particularly limited as long as it is in the form of a sheet or a film, but is preferably a heat-sealable material. Specifically, polyethylene, Surlyn, ethylene / vinyl acetate copolymer, A packaging material using a heat-sealing plastic sheet such as an ethylene / vinyl alcohol copolymer or Hytron is suitable. In particular, in order to prevent volatilization or dispersion of the transdermally absorbable drug contained in the pressure-sensitive adhesive sheet 1, it is preferable to use a laminate of a gas-impermeable film such as a polyester film or a metal foil. When a transdermal drug which does not volatilize or disperse is used, it goes without saying that a gas permeable sheet such as paper or nonwoven fabric may be laminated. As the packaging material 6, a material having a thickness of usually 10 μm to 200 μm is used.

In the pressure-sensitive adhesive sheet 1, the pressure-sensitive adhesive layer 4
Because the woven or knitted fabric 3 sandwiched between the support 2 and the support 2 forms irregularities on the back side of the support 2, when wrapped with the packaging material 6, the convex portions 12 on the back of the support 2 are formed. The contact area between the back surface of the support 2 and the packaging material 6 is reduced only by the contact of the packaging material 6 with the packaging material 6, and a gap can be secured between the two.
Therefore, even if the adhesive or the like oozing out from the end surface of the pressure-sensitive adhesive layer 4 wraps around the back surface of the support 2, the entire back surface of the support 2 does not adhere to the inner surface of the packaging material 6, and the pressure-sensitive adhesive sheet 1 is removed. Can be easily removed.

Further, since the woven or knitted fabric 3 is merely superimposed on the pressure-sensitive adhesive layer 4, the manufacturing process is not complicated,
As compared with the case where the separator 5 having the protruding portion formed on the outer peripheral edge is used, the material cost can be reduced and the cost can be reduced. Also,
There is an advantage that the material cost and the manufacturing cost can be reduced as compared with the case where the unevenness is formed on the back surface of the support 2 by using the support 2 having the back surface embossed.

In the pressure-sensitive adhesive sheet 1 of the above embodiment, the case where a woven fabric or a knitted fabric 3 in which yarn is knitted is used as the unevenness forming member has been described. The material and shape of the unevenness forming member are not particularly limited. For example, as shown in FIG. 6, a plastic or cloth sheet 8 provided with a large number of openings 13 by a punch or the like in a circular or rectangular shape at regular intervals may be used. The use of the sheet 8 (concavity and convexity forming member) also allows the adhesive to enter through the opening 13 and easily form concavities and convexities on the back surface of the support 2, thereby preventing sticking to the inner surface of the packaging material 6. be able to. Further, in the above embodiment, the recesses 11 are arranged vertically and horizontally. However, it is not always necessary to arrange the recesses 11 vertically and horizontally. Irregularities can also be formed on the back surface.

[0032]

EXAMPLES Next, pressure-sensitive adhesive sheets according to examples of the present invention were prepared, and the effects of the present invention were confirmed.

(Examples 1 to 18) The solid content of an acrylic pressure-sensitive adhesive solution obtained by copolymerizing 95 parts by weight of 2-ethylhexyl acrylate and 5 parts by weight of acrylic acid in an organic solvent was 6%.
0 parts by weight of isopropyl myristate (IPM) 40
After mixing by weight, 0.14 parts by weight of polyisocyanate (trade name, Coronate HL, manufactured by Nippon Polyurethane Co., Ltd.) was added to 100 parts by weight of the solid content of the adhesive to carry out crosslinking treatment, and ethyl acetate was added. Adhesive solid content 30w /
A w% adhesive solution was obtained.

The pressure-sensitive adhesive solution thus obtained was applied on a separator made of polyethylene terephthalate so that the thickness after drying was as shown in Table 1, and then dried to form a pressure-sensitive adhesive layer. Next, on this adhesive layer, the size of the opening is 0.1 to 0.3 mm and the thickness is 220 to 300 mm.
layer of polyester woven fabric of μm, and a thickness of 6 μm
The support made of polyethylene terephthalate was stuck to prepare pressure-sensitive adhesive sheets of Examples 1 to 18. In addition,
When the pressure-sensitive adhesive did not sufficiently exude from the opening, a necessary amount of the pressure-sensitive adhesive was applied to the surface of the support as needed, and then bonded.

(Examples 19 to 22) Further, pressure-sensitive adhesive sheets of Examples 19 to 22 were prepared using different pressure-sensitive adhesives. 2
-Ethyl acetate was added to an acrylic pressure-sensitive adhesive solution obtained by copolymerizing 95 parts by weight of ethylhexyl acrylate and 5 parts by weight of acrylic acid in an organic solvent to obtain a pressure-sensitive adhesive solution having a solid content of 30 w / w%. The pressure-sensitive adhesive solution thus obtained was applied on a separator made of polyethylene terephthalate so that the thickness after drying became the thickness shown in Table 2, and then dried to prepare a pressure-sensitive adhesive layer. Next, to this adhesive layer,
A woven cloth having an opening size of 0.3 mm and a thickness of 220 μm was overlapped, and a support made of polyethylene terephthalate having a thickness of 6 μm was bonded to prepare adhesive sheets of Examples 19 to 22.

(Comparative Examples 1 to 6) Next, Table 3 was used as a comparative example.
As shown in, an adhesive layer was prepared using a crosslinked acrylic adhesive obtained in the same manner as in Examples 1 to 18, and the size of the opening was 0.3 mm on this adhesive layer, and the thickness was 0.3 mm. 100
The thickness of the pressure-sensitive adhesive layer is 80 to
The pressure-sensitive adhesive sheets of Comparative Examples 1 to 6 having a thickness of 100 µm were prepared.

Examples 1 to 18 and Examples 19 to 2
2 and each of the pressure-sensitive adhesive sheets of Comparative Examples 1 to 6 were heat-sealed with a packaging material made of a polyethylene sheet, and there was no problem in the unevenness formed on the back surface of the support of the pressure-sensitive adhesive sheet, and the removal from the packaging material was smooth. An evaluation was made as to whether or not the evaluation was successful, and the results are shown in Tables 1, 2 and 3. In the evaluation column in the table, the mark ○ indicates that sufficient irregularities were formed on the back surface of the support, and the take-out property from the packaging material was good, and the mark x indicates that the adhesive sheet was on the inner surface of the packaging material. It shows that it was attached and the take-out property was poor. In addition, the area of the convex portion is obtained by calculating the size of the circular (or circular), assuming that the convex portion is substantially circular or annular.
It was calculated by rough estimation.

[0038]

[Table 1]

[0039]

[Table 2]

[0040]

[Table 3]

As can be seen from Tables 1 to 3, when the height of the convex portion is formed to be 130 μm or more, sufficient unevenness is formed on the back surface of the support and the take-out property from the packaging material is good. On the other hand, the protrusions lower than 130 μm had poor takeout properties from the packaging material.

[0042]

According to the pressure-sensitive adhesive sheet of the present invention, in a pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer formed on a support, an uneven forming member is sandwiched between the support and the pressure-sensitive adhesive layer, and the back surface of the support is Since the irregularities of a specific height are formed, the contact area with the inner surface of the packaging material is reduced, and even if the adhesive wraps around from the end surface of the adhesive layer to the back surface of the support, the adhesive remains on the inner surface of the packaging material. To adhere to the surface. Therefore, even when the pressure-sensitive adhesive sheets are individually wrapped, they can be easily taken out of the packaging material. In addition, even when two or three sheets are stacked, the adhesive sheets are not bonded to each other, and the sheets can be peeled off one by one and easily taken out.

It is particularly preferable that the total plane area of the projections formed on the back surface of the support is set to 5 to 40% of the total plane area of the back surface of the support, so that it can be easily taken out from the packaging material.

By using a net-shaped woven or knitted fabric having a large number of openings, for example,
Irregularities can be formed on the back surface of the support at low cost. At this time, the size of the opening of the woven or knitted fabric is 0.1 mm to
By setting the thickness to 20 mm, irregularities can be effectively formed.

This is an effective method especially when used as a drug-containing pressure-sensitive adhesive sheet often packaged individually.
By containing a transdermally absorbable drug in the pressure-sensitive adhesive layer, it can be applied as a drug-containing pressure-sensitive adhesive sheet.

[Brief description of the drawings]

FIG. 1 is a partially broken perspective view showing a pressure-sensitive adhesive sheet according to one embodiment of the present invention, which is viewed from a support side.

FIG. 2 is a perspective view showing the pressure-sensitive adhesive sheet from the separator side.

FIG. 3 is a cross-sectional view of the pressure-sensitive adhesive sheet shown in FIG.

FIG. 4 is a perspective view showing a state in which the pressure-sensitive adhesive sheet is packaged with a packaging material.

FIG. 5 is a cross-sectional view of the pressure-sensitive adhesive sheet, which is wrapped with a packaging material.

FIG. 6 is a perspective view showing another uneven forming member that can be used for the pressure-sensitive adhesive sheet of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Adhesive sheet 2 Support 3 Woven or knitted fabric (unevenness forming member) 4 Adhesive layer 5 Separator 8 Sheet provided with an opening (unevenness forming member) 11 Concave formed on back of support 12 Back of support Protrusion 13 formed Opening

Claims (5)

[Claims] 1. A pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer formed on a support, wherein an uneven forming member is sandwiched between the support and the pressure-sensitive adhesive layer, and has a height of 130 μm to 1 mm on the back surface of the support. An adhesive sheet having irregularities formed thereon. 2. The adhesive according to claim 1, wherein the total plane area of the projections of the unevenness formed on the back surface of the support is 5 to 40% of the total plane area of the back surface of the support. Sheet. 3. The pressure-sensitive adhesive sheet according to claim 1, wherein the unevenness forming member is a net-shaped woven or knitted fabric having a large number of openings. 4. The woven or knitted fabric according to claim 3, wherein the size of the opening is 0.1 mm to 20 mm.
The pressure-sensitive adhesive sheet according to 1. 5. The pressure-sensitive adhesive sheet according to claim 1, wherein the pressure-sensitive adhesive layer contains a transdermally absorbable drug.