JPH1043578A - Production of endoplasmic reticulum dispersion liquid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a production method of an endoplasmic reticulum dispersion liquid so that endoplasmic reticulum having a two-molecular film multilayered structure including an oil phase show good storage stability and that endoplasmic reticulum having a small particle size can be obtd. SOLUTION: A system comprising a film forming component, oil component and a part of water phase is kneaded at a temp. lower than the phase transition temp. of the film forming component while high shearing force is added so as to produce a liquid crystal compsn. Then the rest of the water phase is added and mixed to the liquid crystal compsn. to form an endoplasmic reticulum dispersion liquid in which the oil component is included in a two- molecular film multilayered structure comprising the film forming component. By this method for forming the endoplasmic reticulum dispersion liquid, endoplasmic reticulum having the oil component surrounded by the two-molecular film multilayered structure can be stably dispersed in water so that the liquid shows such properties that stability of the oil-inlusion can be improved compared to an O/W emulsion and that the endoplasmic reticulum is not easily broken by other components. By this method, the endoplasmic reticulum dispersion liquid having excellent storage stability can be obtd. without causing separation of the oil component in the dispersion liquid during storage, and especially, the endoplasmic reticulum can be formed to a small size as about 0.1 to 0.5μm average particle size as well as various kinds of oil components can be included.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a vesicle dispersion liquid capable of stably encapsulating oils such as hydrocarbons, ester oils, silicone oils and oil-soluble antibacterial agents in a bilayer multilayer structure comprising film-forming components. And a method for producing the same.

[0002]

2. Description of the Related Art
A liposome is a particle having a bilayer multilayer structure, but this is for the purpose of retaining a water-soluble substance in the membrane, and the oil cannot be encapsulated by a general method for producing liposomes.

On the other hand, Japanese Patent Application Laid-Open No. 6-269656 describes a method for producing an oil-in-water emulsion in which an oil component is retained in a vesicle structure. It was difficult for the emulsion to completely retain the oil under storage conditions. JP-B-63-33414 proposes a method for producing a dispersion of particles having a bilayer multilayer structure. In this method, the resulting dispersion is incorporated into the bilayer multilayer structure. What is disclosed is an aqueous phase, and there is no disclosure of an oil phase. further,
Japanese Patent Application Laid-Open No. 5-1941989 discloses a method of emulsifying a fragrance with a nonionic activator to form a structured emulsion containing a liquid crystal structure surrounding the fragrance, and dispersing the structured emulsion in a detergent composition. In this method, a non-aqueous phase is directly dispersed in the entire aqueous phase,
Since this is mixed under low shear conditions to form a structured emulsion, not only can relatively large particles be produced, but also the stability of the particles in the dispersion at high temperatures is poor. there were.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to obtain vesicles having a storage stability of vesicles containing oil in a multilayer bilayer structure and having a fine particle size. It is an object of the present invention to provide a method for producing an endoplasmic reticulum dispersion liquid that can be used.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, the film-forming component, the oil component, and a part of the aqueous phase were mixed as a whole. By adding high shear while kneading, a liquid crystal composition in which oil is dispersed in minute units in a bilayer film multilayer structure of film forming components is formed, and the liquid crystal composition and the remaining aqueous phase are further combined. By mixing and producing the vesicle dispersion liquid, not only can vesicles containing an oil component contained in the dispersion liquid by the bilayer membrane multilayer structure be stably formed, and particularly, the average particle diameter is 0.1 to 0. The present inventors have found that fine and uniform vesicles having a size of about 0.5 μm are formed, and have accomplished the present invention.

Accordingly, the present invention provides a method of kneading a system comprising a film-forming component, an oil component and a part of an aqueous phase under high shear at a temperature not lower than the phase transition of the film-forming component to form a liquid crystal composition. After forming the product, the remaining amount of the aqueous phase is added to and mixed with the liquid crystal composition to form a vesicle dispersion liquid in which the oil is incorporated into a bilayer film multilayer structure comprising film forming components. And a method for producing a vesicle dispersion.

Now, the present invention will be described in further detail. The method for producing a vesicle dispersion according to the present invention comprises a film-forming component,
An oil component and an aqueous phase component are used.

Here, the type of the film-forming component is not particularly limited as long as it forms a bilayer multilayer, but a quaternary ammonium salt represented by the following general formula (1) and a tertiary ammonium salt One or more selected from cationic surfactants such as amine salts, imidazoline salts, imidazolinium salts, amino acid-based cationic surfactants, or represented by the following general formula (2) together with the above cationic surfactants Mixtures with higher alcohols are preferably used, of which quaternary ammonium salts are particularly preferred.

[0009]

Embedded image (Where R ¹ is an alkyl group or alkenyl group having 10 to 24 carbon atoms, R ² is an alkyl group having 1 to 3 carbon atoms, an alkyl group or alkenyl group having 10 to 24 carbon atoms,
¹ and R ² may each be unsubstituted;
It is divided by a functional group such as CONH- or -COO-
It may be substituted with a functional group such as H. R ³ has 1 carbon atom
And R ⁴ is an alkyl group having 1 to 3 carbon atoms or a benzyl group, and X is a halogen atom or a monoalkyl sulfate group. R ⁵ —OH (2) (wherein, R ⁵ is an alkyl group having 12 to 22 carbon atoms)

Specific examples of the film-forming component include quaternary ammonium salts of the formula (1): stearyltrimethylammonium chloride, distearyldimethylammonium chloride, dodecyltrimethylammonium chloride, ditallowalkyldimethylammonium bromide, and dioleyldimethyl. Amino acid-based cationic surfactants such as ammonium chloride, oleyltrimethylammonium chloride and the like are exemplified by coconut oil fatty acid L-arginineethyl-DL-pyrrolidonecarboxylic acid, 4-guanidinobutyllauryl amide acetic acid and the like.
Examples of the tertiary amine salts include distearylmethylamine hydrochloride, dioleylmethylamine hydrochloride, distearylmethylamine sulfate, and the like. In the case of these tertiary amine salts, the alkyl chain is represented by -COO-, -CONH- And the like. Examples of imidazoline salts include 1-octadecanoylaminoethyl-2-heptadecylimidazoline hydrochloride, 1-octadecenoylaminoethyl-2-heptadecenyl imidazoline hydrochloride, and the like. Tallowamidoethyl-
2-tallowalkyl imidazolinium methyl sulfate, methyl-1-hexadecanoylamidoethyl-2-
Pentadecyl imidazolinium chloride, ethyl-1
Examples of higher alcohols of the formula (2) such as octadecenoylamidoethyl-2-heptadecenyl imidazolinium ethyl sulfate include cetostearyl alcohol, dodecyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol. These film-forming components can be appropriately selected depending on the use and purpose of the vesicle dispersion to be produced. For example, when the dispersion is a clothing finish or a cosmetic, it is used as a clothing finish base. A cationic surfactant to be used or a cationic surfactant to be used as a base of cosmetics and a higher alcohol are preferably used.

The amount of the film-forming component used is about 1 to 40% by weight, preferably about 3 to 30% by weight, based on the whole dispersion. If the amount is too small, encapsulation of the oil may be difficult, while if the amount is excessive, vesicle formation may be difficult.

In the present invention, in order to facilitate the formation of a film by the film-forming component, an organic solvent such as a polyhydric alcohol such as ethylene glycol, propylene glycol or glycerin or a lower alcohol such as ethanol or isopropyl alcohol is used together with the film-forming component. Solvents and additives such as fatty acids such as stearic acid and oleic acid and various emulsifiers such as polyoxyethylene alkyl ether, sorbitan fatty acid ester, and polyoxyethylene sorbitan fatty acid ester can be blended in usual amounts.

Next, as the oil component, hydrophobic oil components used in products in various fields such as finishing agents for clothing, cosmetics, pharmaceuticals, and detergents can be used.
Those having functions such as changing the texture of clothing, giving a moisturizing effect to the skin, giving nutrition to the hair, and giving an antibacterial / bactericidal effect are preferably used. Specifically, for example, synthetic oils such as silicone oil, cyclic silicone and modified silicone, mineral oils such as liquid paraffin, liquid isoparaffin and paraffin wax, vegetable oils such as jojoba oil, olive oil, olive squalane, castor oil, carnauba wax, and lanolin , Squalane, mink oil and other animal oils,
Hexyl laurate, isopropyl palmitate, oleic acid, stearic acid and the like can be mentioned. More specific functions are oil-soluble antibacterial / bactericides such as triclosan, hinokitiol, triclocarban, isopropylmethylphenol, butylparaben, propyl Oil-soluble preservatives such as paraben, benzoic acid, salicylic acid, and sorbic acid; oil-soluble antioxidants such as dibutylhydroxytoluene, butylhydroxyanisole and tocopherol; oil-soluble flavors such as linalool, citronellol, geraniol, and geranyl acetate; Other examples include oil-soluble UV absorbers, insect repellents, humectants, and the like. These can be used alone or in an appropriate combination of two or more.

The amount of the oil used is preferably about 0.1 to 20% by weight based on the whole dispersion, and the ratio of the oil to the film forming component is 1: 1.
It is desirably 1 or less, and if the oil content exceeds the film-forming component, the inclusion in the bilayer multilayer structure may be insufficient. When the melting point of the oil used is high, it may be used by dissolving it in an organic solvent such as a lower alcohol as described above or another liquid oil.

Examples of the aqueous phase component include, in addition to water, emulsifiers, dispersion stabilizers, low-temperature stabilizers, inorganic salts, pigments, and various other water-soluble active ingredients. Specifically, nonionic surfactants such as polyoxyethylene nonylphenyl ether, polyoxyethylene octyl phenyl ether, glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, and fatty acid polyethylene glycol as emulsifiers, Dispersion stabilizers such as polyacrylic acid, carboxymethylcellulose and carboxyvinyl polymer; low-temperature stabilizers such as ethylene glycol, propylene glycol and glycerin; and inorganic salts such as sodium chloride, calcium chloride and other hydrochlorides, and sodium sulfate and other sulfates. Acid Red 13 as a dye
8, Acid Blue 9, Acid Yellow 141, Reactive Blue, and other various water-soluble active ingredients include antibacterial agents such as isothiazolone and antioxidants such as hydroxyethanediphosphonic acid. The amount of the aqueous phase component can be a normal amount.

In the production method of the present invention, a liquid crystal composition is formed by mixing and kneading the above-mentioned film-forming component, an oil component and a part of the aqueous phase while applying high shear thereto. By adding and mixing the remaining amount of the aqueous phase to the product, a vesicle dispersion liquid in which the oil is included in the bilayer membrane multilayer structure composed of the film forming components is produced. In this case, the continuous phase becomes an aqueous phase.

Here, the formation temperature of the liquid crystal composition needs to be not lower than the phase transition temperature (Tc) of the film forming component. If the liquid crystal composition formation temperature is lower than Tc, no liquid crystal is formed. The temperature difference between the liquid crystal composition formation temperature and Tc is not particularly limited, and can be appropriately selected within a temperature range in which liquid crystal can be formed. Usually, the liquid crystal composition formation temperature is higher than Tc. 5-20 ° C, especially 10-1
It is desirable that the temperature be higher by about 5 ° C.

The amount of the aqueous phase mixed with the film-forming component and the oil to form the liquid crystal composition is appropriately selected depending on the type of the film-forming component and the oil used. It is preferable that the amount is 10 to 50% of the total amount of the phase, and the ratio of oil phase (film-forming component and oil component): water phase = 1: 0.5 to 1: 2 in the liquid crystal composition. And
When mixing the film-forming component, the oil component and a part of the aqueous phase,
The order in which these are added to the container is not particularly limited, and they may all be added simultaneously.

The type of the apparatus for kneading by adding high shear while mixing each of the above components is not particularly limited.
Considering that the viscosity of the system increases as the liquid crystal composition is formed, it is desirable that the system be capable of mixing the high-viscosity material as a whole and have blades with high shearing force. Here, the types of the stirring devices can be broadly classified into two types: a device capable of securing the stirring characteristics by one set of blades and a device capable of securing the stirring characteristics by a plurality of sets of blades. The shearing applied in the production method of the present invention will be described below.

First, an apparatus capable of ensuring the overall mixing and high shearing force with one set of blades will be described with reference to the drawings. In the case of this type of apparatus, as shown in FIG. 1, the shearing force is generally dominated by the peripheral speed of the tip of the blade 2 in the stirring tank 1 in consideration of stirring characteristics. The power of rotation of the blades 2 per unit liquid volume in the entirety 1 and the discharge flow rate of the blades 2 per unit liquid volume in the entire stirring tank 1 are dominant. Therefore, in order to add high shear in the present invention, it is necessary to pay attention to the peripheral speed at the tip of the blade 2,
In the case of the present invention, the level of the peripheral speed Ut [m / s] at the tip of the blade 2 is 5 m / s or more, preferably 7 m / s or more and 25 m / s or less, more preferably 10 m or more regardless of the size of the device. / S to 25 m / s, high shear can be added. The peripheral speed Ut at the tip of the blade 2 can be calculated by the following equation.

Ut = π × n × dn: blade rotation speed [rps], d: blade diameter [m]

In this case, the degree of shearing can be defined by the peripheral speed Ut, but it is necessary to consider a factor relating to the size of the apparatus in order to secure the overall mixing force. Desirably, it is defined by the apparent shear rate.

Apparent shear rate = Ut / (D−d) Ut: shear rate [m / s], d: blade diameter [m], D: stirring tank diameter [m]

In the case of a normal kneading apparatus, if the peripheral speed Ut at the tip of the blade 2 is kept constant, the blade 2 becomes larger as the apparatus becomes larger.
The distance between the agitator and the stirring tank 1 increases, and the value of the apparent shear rate decreases. When the high shear of the present invention is defined by using such an apparent shear rate, the apparent shear rate is preferably about 100 to 1000 [s ^-1 ].

In order to simultaneously secure the shearing force and the overall mixing, it is preferable to set the ratio d / D of the blade diameter d to the stirring tank diameter D to 0.7 or more. The upper limit is preferably 0.9 or less. As a specific device having such stirring characteristics, for example, a line mixer, a power mixer, a spiral mixer, or the like is preferably used.

Next, as an apparatus having a plurality of sets of blades, as shown in FIG. 2, a blade 2 capable of giving high shear and a stator 3 having an inner diameter D 'surrounding the blade 2 are mixed as a whole. A device provided with a scraping-type blade 4 that can perform the cleaning is used. In the case of such a device, in order to apply the high shear of the present invention, the peripheral speed Ut [m / s] of the tip of the blade 2 is required.
Is 5 m / s or more, preferably 7 m / s or more.
m / s or less, more preferably 10 m / s or more and 25 m / s
The apparent shear rate calculated by using the inner diameter D 'of the stator 3 in place of D is 1,000
It is preferable to set it to about 10,000 [s ^-1 ]. In addition, in the case of a device provided with a plurality of sets of blades, as shown in FIG. 3 separately from the above-described device, a blade 2 capable of normally applying high shear and a scraping type blade 4 capable of performing overall mixing are provided. A device provided with is also used. In the case of such a device, in order to apply the high shear of the present invention, it is necessary to pay attention to the peripheral speed at the tip of the blade 2 as described above, and the degree is 5 m.
/ S, preferably 7 m / s or more and 25 m / s or less, more preferably 10 m / s or more and 25 m / s or less, whereby high shear can be added.

In an apparatus having a plurality of sets of blades as described above, examples of the blades 2 capable of imparting the stirring characteristics include a homomixer and a disper mixer.
Usually, the ratio d / D between the blade diameter and the stirring tank diameter is 0.2
Considering that the viscosity of the system increases as the liquid crystal composition is formed, it is insufficient to mix the entire stirring tank with only the blades 2.
Therefore, a scraping-type blade 4 suitable for mixing a high-viscosity material is suitably used. In this case, in order to efficiently supply a liquid to the blade 2 to which high shear is applied, a scraping-type blade 4 is required. It is preferable to add a flow of 1 m / s or more as the peripheral speed at the tip of the blade 4.

As a specific apparatus having these stirring characteristics, it is preferable to use, for example, an azihomomixer, a backflow mixer, a hybrid mixer, or the like.

According to the present invention, by such a kneading step,
A liquid crystal composition is formed from a liquid mixture composed of a film-forming component, an oil component, and a part of an aqueous phase.In such a step, whether or not the liquid crystal composition is formed depends on whether the liquid crystal composition is formed. Since the viscosity of the system becomes as high as several hundreds to several tens of thousands P (poise), it can be confirmed by utilizing this change in viscosity.

Here, the system in which such a liquid crystal composition was formed was frozen and then cut, and the cut surface was removed and observed with a transmission electron microscope. As a result, the existence of a multilayer structure was confirmed. . This multilayer structure is formed by a bilayer and a water layer formed by a film-forming component. In this case, the molecules of the film-forming component are arranged with their hydrophobic groups directed toward the inside of the film. Is considered to be dispersed in minute units between the hydrophobic groups of such two molecules.

According to the production method of the present invention, the liquid crystal composition and the remainder of the aqueous phase are mixed to obtain a desired vesicle dispersion liquid. Although it can be produced even at a temperature lower than the above phase transition temperature, it is preferable to carry out at a temperature higher than the above phase transition temperature in consideration of the solidification of the film forming components. The order of adding the liquid crystal composition and the remaining aqueous phase is not particularly limited, and they may be added simultaneously, for example. The shearing force in the mixing / dispersing step is not particularly limited, and may be any shearing force in the ordinary emulsifying and dispersing step, that is, the normal use range of a machine used for ordinary emulsifying and dispersing. In the case of the present invention, in consideration of the fact that the viscosity of the liquid crystal composition is high, it is desirable to lengthen the residence time and increase the time required for shearing.

Therefore, in the mixing / dispersing step of the present invention, a usual device for emulsification and dispersion is used. As such a device, a high-shear type dispersion device is usually used. Examples thereof include a homomixer, a milder, a clear mix, a line mixer, an ajihomomixer, a homomic line flow, a disper mixer, and a backflow mixer. These may be used alone or in an appropriate combination of two or more. You may. In this case, since the viscosity of the system is about several tens to several hundreds cP (centipoise), the scraping blade may or may not be provided.

In the production method of the present invention, a pigment or the like may be further added to the vesicle dispersion obtained in the above step, or cooling may be performed after the dispersion step. Further, the temperature in the finishing step (the step in which the vesicle dispersion liquid is formed) may be higher than the transition point of the film-forming component, or lower than the phase transition point, and the bilayer of the bilayer multilayer structure is solidified. State.

The vesicle dispersion obtained by the production method of the present invention can be commercialized using only the vesicle dispersion, and the vesicle dispersion is mixed with other products as a raw material. Can also. Therefore, these vesicle dispersions can be used as they are as finishing agents for clothing, cosmetics, detergents, and the like, or can be used as a mixture of other materials.

[0035]

According to the method for producing a vesicle dispersion of the present invention, vesicles in which oil is firmly wrapped in a bilayer multilayer structure can be stably dispersed in water.
It is possible to obtain an vesicle dispersion in which the stability of inclusion of oil is improved as compared with the emulsion of the type, and the vesicles are not easily destroyed by the presence of other components. Also,
According to the method for producing an endoplasmic reticulum dispersion of the present invention, an endoplasmic reticulum dispersion having excellent storage stability can be obtained without separation of an oil component in the dispersion during storage. .1
In addition to being able to be refined to about 0.5 μm, various oil components can be included.

The vesicle dispersion produced by the production method of the present invention has a high adsorption performance to fibers and hair because the oil is incorporated in a bilayer multilayer structure comprising a surfactant and the like. Since it can be adsorbed without waste,
For example, when a softening agent is prepared by using silicone or an antibacterial agent as an oil component, a sliding action by silicone or an antibacterial function by an antibacterial agent can be imparted to clothes. Further, for example, when a hair rinse is prepared using silicone as an oil component and olive oil, squalane or the like as an active ingredient, it is possible to impart to the hair a slipping action of the silicone and a moist feeling by the active ingredient. Furthermore, the skin can be protected by adding the vesicle dispersion containing liquid paraffin to a detergent such as a kitchen detergent. Thus, the vesicle dispersion produced by the production method of the present invention can be effectively used for various uses.

[0037]

EXAMPLES The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples.

[Examples 1 to 4, Comparative Examples 1 and 2] The film-forming components, the oil component and a part of the aqueous phase component shown in Table 1 were preliminarily heated to 50 ° C. The mixture was charged into a liquid crystal forming apparatus shown in the table, and kneaded under the stirring characteristic values shown in Table 1 for the time shown in Table 1 to obtain a liquid crystal composition. Next, this liquid crystal composition and the remaining aqueous phase previously heated to 50 ° C. were charged into a container of a dispersing apparatus described in Table 1, and these were dispersed under high shear to obtain a predetermined vesicle dispersion. Was.

The following evaluation was performed on the obtained vesicle dispersion liquid.
Was done. The results are also shown in Table 1. Confirmation of ER Dispersion liquid 600 times under orthogonal polarization condition using polarization microscope
Observed at, showing the presence of ER with bilayer multilayer structure
Check whether a crossed Nicol image has appeared and use the following criteria
Therefore, it was determined. <Judgment Criteria> 十字: Cross Nicol is visible over a wide range △: Cross Nicol is partially visible ×: Cross Nicol is not visibleEvaluation of stability After the dispersion was cooled to room temperature and left for 1 day,
Observe 0 or more points and observe with a phase contrast microscope
Was. The magnification of the phase contrast microscope is 600 times, and one sample
Observing more than 10 places with a bilayer multilayer structure
Check if unwrapped oil is present, and
It was determined by Also, put the same dispersion in a 50 ° C constant temperature bath.
After standing for one month and three months, the oil level floats on the liquid surface
It was visually observed whether or not there was, and it was determined according to the following criteria. What
The dispersion of Example 2 and the dispersion of Comparative Example 1 were heated at 50 ° C.
After storing for months, the photograph was taken with an optical microscope (magnification: 600).
These are shown in FIG. 4 (Example 2) and FIG. 5 (Comparative Example 1), respectively.
In FIG. 5, large particles are oil droplets.
According to FIG. 5 and FIG. 5, the vesicle dispersion of the present invention
Compared to the ER dispersion (conventional ER dispersion),
Small ERs are observed to be dispersed. <Criteria for phase contrast microscopy> 〇: Oil not wrapped in a bilayer multilayer structure was observed
No ×: Oil not wrapped in the bilayer multilayer structure exists <Criteria of storage stability> 〇: No oil droplets exist on the liquid surface ×: Oil droplets exist on the liquid surface

[0040]

[Table 1]

According to the results shown in Table 1, the peripheral speed (Ut) at the time of forming the liquid crystal composition was 5 m / s or more, and the apparent shear rate was 100 to 1,000 (s ^-1 ) to obtain high shear. In the case of the added production method of the present invention (Examples 1 to 3) and when high shear was added using an azihomomixer (Example 4), a stable vesicle dispersion liquid was obtained even under severe storage conditions. In contrast, the liquid crystal composition has a peripheral speed (Ut) of 5 m / s.
When formed under low shear of less than (Comparative Example 1), it is recognized that the obtained vesicle dispersion liquid cannot be tolerated under severe storage conditions. On the other hand, when the components were manually stirred and the film-forming component and the oil component were dispersed in the aqueous phase without forming the liquid crystal composition (Comparative Example 2), it seems that vesicles were formed to some extent. , No oil was encapsulated.

[Examples 5 to 13] The film-forming components, the oil and a part of the aqueous phase shown in Table 2 were preliminarily heated to 50 ° C, and these were mixed with a line mixer (the same equipment as in Example 1).
Stirring value), knead under high shear for 30 seconds,
A liquid crystal composition was obtained. Next, this liquid crystal composition and 50
The remaining aqueous phase heated to ° C. was charged into a container of a dispersing apparatus shown in Table 1, and these were dispersed under high shear to obtain a predetermined vesicle dispersion.

With respect to the obtained vesicle dispersion liquid, the presence of vesicles was confirmed and the stability of the vesicles was evaluated in the same manner as in Examples 1 to 4. The results are also shown in Table 2.

[0044]

[Table 2]

According to the results shown in Table 2, dispersions of vesicles containing various oils were obtained by the production method of the present invention, and these vesicle dispersions were stable under severe storage conditions. Is recognized.

Examples 14 to 20 Examples 5 to 13
, A dispersion was prepared in the same manner as in Examples 5 to 13 except that the composition shown in Table 3 was used instead of each composition, and the presence of vesicles in the obtained dispersion was confirmed and the vesicles were stabilized. The properties were evaluated in the same manner as in Examples 5 to 13. The results are also shown in Table 3.

[0047]

[Table 3]

According to the results shown in Table 3, it is recognized that the production method of the present invention can provide a vesicle dispersion in which oil is stably incorporated by various film-forming components.

Next, the vesicle dispersion obtained in Example 1 was used as a softener for clothing and subjected to the treatment of female stockings, and as a control, the feeling of use with stockings treated with the conventional softener was evaluated by 10 panelists. As a result of comparison, eight panelists evaluated that the stockings treated in Example 1 did not catch and were easier to wear than the stockings treated with the conventional softener treatment.

The vesicle dispersion prepared in Example 9 was used as a softening agent for clothing, socks were treated, and as a control, a commercially available softening agent (Sofran C, manufactured by Lion Corporation) was used. When 10 panelists wore the sock on the left and right for 1 day, and the socks were taken off, the evaluation was that the 7 panelists treated in Example 9 did not smell worse than the commercial product. Did.

[Brief description of the drawings]

FIG. 1 is a schematic sectional view of an example of an apparatus for forming a liquid crystal composition in the present invention.

FIG. 2 is a schematic sectional view of another example of a device for forming a liquid crystal composition in the present invention.

FIG. 3 is a schematic sectional view of still another example of an apparatus for forming a liquid crystal composition in the present invention.

FIG. 4 is an optical micrograph of the vesicle dispersion of Example 2 after storage at 50 ° C. for 3 months.

FIG. 5 is an optical micrograph of the vesicle dispersion of Comparative Example 1 after storage at 50 ° C. for 3 months.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification number Agency reference number FI Technical indication // A61K 7/08 A61K 9/127 C9 / 127 B01J 13/02 Z

Claims (1)

[Claims] 1. A liquid crystal composition is formed by kneading a system comprising a film-forming component, an oil component and a part of an aqueous phase under high shear at a temperature not lower than the phase transition of the film-forming component. After that, the remaining amount of the aqueous phase is added to and mixed with the liquid crystal composition to form a vesicle dispersion liquid in which the oil is incorporated into a bilayer film multilayer structure comprising film-forming components. A method for producing a cell dispersion.