JPH10316507A - Miticide - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a miticide against indoor ticks which is high in safety, possesses the characteristic that it is hard for ticks to get tolerance and is suitable for tick preventive treatment for living materials such as bedclothes and carpets. SOLUTION: This miticide against indoor ticks containing farnesyl acetone as an active ingredient is excellent in the repellent effect on Tyrophagus putrescentiae, Dermatophagoides farinae (American house dust mite) and Dermatophagoides pteronyssinus (European house dust mite) and possesses the characteristic that it is hard for these ticks to get drug tolerance. The molding products such as fibers and films having tick preventive effect can be used for mats, bedclothes and carpets having tick preventive effect due to this miticide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a mite control agent containing farnesylacetone as an active ingredient and a molded article provided with mite control properties by the mite control agent. Indoor ticks cause allergic diseases such as bites, rhinitis, bronchial asthma, and atopic dermatitis. The increase in indoor mites is largely due to the change in the living environment in Japan, and it is thought that the increase in the environment suitable for mites, such as the spread of highly airtight houses and the increase in textiles due to the westernization of the interior, is increasing the damage. Therefore, these measures are strongly required.

[0002]

2. Description of the Related Art As compounds having an acaricidal action, organophosphorus, pyrethroid or carbamate compounds are known. However, for the purpose of controlling ticks, when living materials that are in daily contact with the human body such as tatami, bedding, carpets, and futon, which are the habitat of the ticks, are tick-proofed, safety to the human body is the highest priority. Therefore, in general, a mitic repellent whose physiological action is alleviated more than acaricide is often used (Journal of the Textile Machinery Society, Vol. 46, 241-24).
8 (1993)).

It has been proposed to use a terpene compound as a plant component as a highly safe mite control agent (Japanese Patent Application Laid-Open No. 63-104905 and Kyoto Prefectural Public Research Institute Annual Report, Vol. 35, pp. 95-100). (1990).
These terpene compounds often exert an acaricidal effect when applied in a large amount, but many of them exert a tick repellent effect as a main mechanism in an amount actually applied to living materials. However, when a terpene compound is allowed to act for a long time in an amount that exhibits the above-described repellent action, ticks often acquire resistance to these drugs, and the effect is that the action does not last for a long time. It has become.

[0004]

An object of the present invention is to provide an inexpensive mite control agent that maintains high safety, hardly causes the mite to acquire resistance, maintains the mite repellent effect for a long time, and is inexpensive. It was made for the purpose of. Further, the purpose of the present invention is to provide various molded articles as living materials that serve as habitats for mites with the above-mentioned mite controlling agent to impart mite control properties.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies for the development of a new mite control agent which solves the above problems, and as a result, linalool, nerol, citral, and citronellol induce induction of mite resistance. While confirming that the repellent effect is short-lived, farnesylacetone belonging to the terpene compound is unexpectedly harder to develop tick resistance while having higher mite repellent activity than these drugs. It has been found that the present invention has the characteristic activity of the present invention.

The present inventors have also proposed, for example, fibers, films, and other molded articles having mite control properties that can be obtained by mixing the mite control agent of the present invention into a resin and melt-molding the resin. Is tatami, bedding, carpet,
By using as a raw material for the production of living materials that will be the habitat of mites in dwellings such as futon cotton, or by directly using as a product for mite control, or the mite control agent of the present invention on various molded products, For example, it has been found that application of the composition is extremely effective in controlling indoor ticks.

That is, the above objects of the present invention are achieved by the following inventions. (1) A mite control agent comprising farnesylacetone as an active ingredient. (2) A molded article to which mite control properties are imparted by the mite control agent according to the above (1).

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Farnesylacetone, which is an active ingredient of the mite control agent of the present invention, has four types of geometric isomers (cis-cis, cis-trans, trans-cis and trans-trans). Exists. The farnesylacetone used in the mite control agent of the present invention may be any geometric isomer, a mixture of two or more of these geometric isomers, and a mixture of these geometric isomers. The mixing ratio is not particularly limited. Farnesylacetone is an extremely safe drug as shown by the following data. Farnesylacetone (mixing ratio; cis-cis-form: cis-
Trans- and trans-cis: trans-trans = 15: 50: 35) Ames mutagenicity test: negative Rat oral acute toxicity test: LD ₅₀ > 10000 mg /
kg

Farnesylacetone has a mild aroma, and does not impair the comfort even when used for controlling mites on living materials such as tatami, bedding, carpets and futon. Farnesylacetone is a compound that is produced in a large amount by a chemical synthesis method for use as a raw material for side chain synthesis of vitamin E and the like.

The farnesylacetone used in the present invention exerts an excellent repellent effect on acarid mites, such as Acarina acarina, which is a habit of the ticks that cause biting, so that the use of the mite control agent of the present invention will control the mites. It is possible to Furthermore, it exerts an excellent repellent effect on dust mites such as Dermatophagoides farinae and Dermatophagoides farinae, which cause allergic diseases such as childhood asthma, atopic dermatitis and rhinitis. Further, farnesylacetone exhibits a characteristic action that hardly develops mite resistance, and thus can exhibit its mite control effect over a long period of time. Accordingly, the ticks, bedding, carpets, and the like, which are the habitats of these indoor ticks, are applied to the mite control agent of the present invention.
By applying to futon and the like, it is possible to efficiently control mites and prevent biting and allergic diseases without impairing comfort.

In the mite control agent of the present invention, farnesylacetone can be used alone without adding other components. However, a carrier, an emulsifier, a stabilizer and the like are compounded in order to make the mite control agent easy to use. It can be used as a preparation by diluting it as necessary. Also,
In the mite control agent of the present invention, other mite control agents can be used in addition to farnesylacetone, further,
If necessary, other compounding ingredients such as a holding substance, a binder, a paint, a fragrance, a dye, and the like can be added.

The mite control agent of the present invention can be prepared by a known method.
For example, aerosols, oils, fumigants, powders, microcapsules, can be prepared in any dosage form such as wettable powders,
These materials are sprayed, coated, impregnated or spread on various materials, for example, woven fabric, knitted fabric, wet nonwoven (paper), dry nonwoven, plywood, synthetic resin sheet, synthetic resin plate, etc., for various uses. Can be offered. In this case, the fibers constituting the knitted fabric, woven fabric, and nonwoven fabric include natural fibers,
Regenerated fibers, semi-synthetic fibers, synthetic fibers, inorganic fibers and the like can be mentioned.

Further, the mite control agent of the present invention can be blended into various resins and processed into fibers, films, sheets and other molded articles, and these can be used for housing such as tatami, bedding, carpets and futon wool. Mite can be controlled very effectively by using it as a raw material for producing living materials that will be the habitat of the mites within, or by using the molded product as a member for controlling mites.

Examples of the resin containing the tick controlling agent include cellulose resins, acrylic resins, polyvinyl alcohol resins, saponified ethylene-vinyl acetate copolymers, polyolefin resins, polyamide resins, and polyester resins. Film-forming or fiber-forming resins such as described above. In particular, as the resin to be subjected to melt molding, a thermoplastic resin having a melting point of 130 ° C to 270 ° C is used in consideration of the heat resistance of farnesylacetone. Is preferred.

When the mite control agent of the present invention is mixed with a thermoplastic resin to form a fiber, farnesylacetone is mixed with a polyolefin resin having a relatively low melting point in order to maintain the mite control effect for a longer period of time. As a core portion, and a core-sheath type conjugate fiber in which the core portion is covered with another thermoplastic resin may be used. Further, instead of directly blending farnesylacetone with the resin, it is also possible to pre-load farnesylacetone on a porous carrier such as silica and then blend it with the resin. In this case, it is expected that the sustained release effect will be enhanced.

The amount of farnesylacetone to be used is not particularly limited as long as the desired mite-controlling activity is exhibited. For example, the amount of farnesylacetone may be 0.01 to 1 m2 per unit area of the object to be sprayed, coated, impregnated or spread. It is about 10 to 10 g, preferably 0.1 to 3 g / m 2.

When farnesylacetone is mixed with a resin and melt-processed into a fiber or a film, about 0.1 to 5% by weight, preferably about 0.5 to 3% by weight of the total weight of the fiber or the film. May be contained.

Thus, according to the present invention, a mite controlling agent comprising farnesylacetone as an active ingredient, which is highly safe and has a feature that it is difficult for mite to acquire resistance, and a mite controlling property thereby. Is provided.

In the mite controlling agent of the present invention and the molded article provided with the tick controlling property, farnesylacetone, which is an active ingredient, exhibits a high repellent effect on mites, and mites are resistant to farnesylacetone. Since it has an excellent feature that it is difficult to obtain ticks, the effect of controlling ticks is continuously exhibited.

[0020]

EXAMPLES The present invention will be described below in detail with reference to examples, but the present invention is not limited to these examples.

Test Methods When evaluating the mite repellent performance, the Osaka Prefectural Public Health Research Institute method and the intrusion prevention method are used as general evaluation methods, and these methods require a test time of 24 to 48 hours. Because of the limited nature, overlooking the phenomenon of mite resistance to drugs, it is difficult to say that it reflects the performance of the mite control product in the actual living environment, the present inventors,
Based on these test methods, the test period is extended to 3 days or more, and the presence or absence of mite resistance is confirmed by examining the change in the repellency of the mites during the test period with time under a stereoscopic microscope. An improved test method was developed. The method of the mite repellency test developed by the present inventors is as follows.

There are two types of test methods, the A method which is an improvement of the Osaka Public Health Research Institute method and the B method which is an improvement of the intrusion prevention method. A sample treated with an acaricide or a non-treated control sample was cut into a circle to cover the entire bottom surface of a petri dish having a diameter of 4 cm, laid on the bottom of the petri dish, and 50 mg or 200 mg of a fresh mite breeding medium was placed in the center. Put on
The test group or the control group, respectively. Further, the petri dishes of the test group and the control group are fixed in combination as shown in FIG. 1 or FIG. In method A, 5,000 test mites together with a breeding medium were placed in a 9 cm-diameter petri dish with a test or control section fixed in the center in a 4 cm-diameter empty petri dish surrounded by a test or control section. Or release 10,000 heads. Next, in order to keep the humidity suitable for the life of the mites, the whole is placed in a container filled with a saturated saline solution, and placed in a thermostat kept at 25 ° C. for 3 days or more. The test container is taken out several times during the test period, and the number of mites that have invaded the fresh medium in the test group and the control group is counted under a stereoscopic microscope each time, and the repellency is determined by the following formula. Repellent rate (%) = (1−mite infestation number in test plot / mite infestation count in control plot) × 100 Changes in repellent rate over time during the test period are tracked for the same test container, thereby mitigating mites. And the presence or absence of mite resistance to the mite repellent component.

Examples 1 and 2 and Comparative Examples 1 to 6 Farnesyl acetone was diluted with methanol at a ratio of 0.3% by weight or 0.6% by weight, and the area of a 0.26 mm thick paper sheet per square meter was measured. 167 g, and methanol was evaporated by air-drying.
Paper sheets were prepared which were impregnated with an amount of 5 g / sq m (Example 1) or 1 g / sq m (Example 2). Further, as Comparative Examples 1 to 6, linalool, nerol, citral, citronellol, geraniol and nerolidol were shown in Table 1.
Was prepared in the same manner as described above. The mite repellent effect of the paper sheets of Examples 1-2 and Comparative Examples 1-6 against Dermatophagoides farinae was evaluated by a modified test method A over a test period of 14 days using a paper sheet containing no drug as a control. Table 1 summarizes the test results
It describes in.

[0024]

[Table 1]

Example 3 In the same manner as in Examples 1 and 2, a paper sheet impregnated with farnesylacetone in an amount of 1 g / m 2 was prepared, and its repellent effect on Dermatophagoides pteronyssinus and Dermatophagoides farinae was determined.
The evaluation was performed using the improved test method A over a test period of 14 days. The test results are shown in Table 2.

[0026]

[Table 2]

Examples 4 to 6 Farnesyl acetone was blended with polyethylene terephthalate pellets at a blending amount of 10% by weight, and kneaded with a single screw extruder at a temperature of 270 ° C. to obtain a master chip. This master chip was added to a drug-free polyethylene terephthalate at various ratios, diluted, supplied to a spinning apparatus, and discharged at a rate of 450 g / min and a winding speed of 900 g.
Per minute at a spinning temperature of 295 ° C. to obtain fibers containing farnesyl acetone at the contents of Examples 4 to 6 shown in Table 3. These fibers were stretched, crimped, and heat-treated in a known manner to obtain raw short fibers having a denier of 6d and a cut length of 51 mm. The repellent effect on Dermatophagoides farinae was evaluated by a modified test method B, using raw cotton formed into a sheet-like cotton having a web of 50 g / sq.m with a card as a sample in a test plot, and using pure polyethylene terephthalate fiber as a control plot.
Table 3 shows the test results.

[0028]

[Table 3]

DISCUSSION As can be seen from the test results shown in Table 1, in Comparative Examples 1 to 6, all compounds show high repellent activity against Dermatophagoides farinae for one day from the start of the test, but repel from day 7 to day 14 A significant decrease in the rate was observed, indicating that the mites had acquired resistance to the test compound. By comparison,
Farnesyl acetone stably maintained high repellent activity during the 14-day test period. Further, from the test results shown in Table 2, it was confirmed that farnesylacetone also has a persistent and high repellent effect on Dermatophagoides pteronyssinus and Dermatophagoides farinae, which are typical mite species that live in rooms other than Dermatophagoides farinae. Furthermore, from the results shown in Table 3,
It was confirmed that even when farnesyl acetone was contained in the polyethylene terephthalate fiber, a sustained and high mite repellent effect was exhibited.

[0030]

EFFECT OF THE INVENTION The mite controlling agent of the present invention and the molded article to which mite controlling properties have been imparted thereby, farnesylacetone, which is an active ingredient, exhibits an excellent repellent action against indoor mite, and the mite control agent It has the feature that resistance is unlikely to occur. Therefore, by applying the mite control agent of the present invention and the molded article imparted with the tick control property to living materials such as tatami, bedding, carpet, and futon which are habitats of mites in a house, Indoor ticks associated with bites or various allergic diseases can be controlled persistently and efficiently, thus helping to prevent these diseases.

[Brief description of the drawings]

FIG. 1 is an explanatory diagram showing a tick repellency test A method employed in the present invention.

FIG. 2 is an explanatory diagram showing a tick repellency test B method employed in the present invention.

Claims (2)

[Claims] 1. A mite control agent comprising farnesylacetone as an active ingredient. 2. A molded article provided with mite control properties by the mite control agent according to claim 1.