JPH10298088A - Composition for curing cold syndrome improved in feeling when taking the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for curing cold syndrome, excellent in feeling in taking it in spite of containing an effective amount of an antipyretic analgesic agent and improved in compliance. SOLUTION: This composition for curing cold syndrome comprises echinacea and an antipyretic analgesic. A mixing ratio is preferably 0.1-50 pts.wt. of the antipyretic analgesic to 1 pt.wt. of echinacea. A large improving effect is obtained by using acetaminophen, ibuprofen, ethenzamide or isopropylantipyrine as the pyretic and analgesic agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a novel composition for treating cold syndrome. Specifically, the present invention is a composition for treating a cold syndrome, comprising an echinacea and an antipyretic analgesic, and having an improved feeling of taking.

[0002]

2. Description of the Related Art The cold syndrome is a general term for acute catarrhal inflammation mainly occurring in the upper respiratory tract. Eighty to 90% of the etiologies are viruses, but cold viruses are numerous and susceptible to mutation. Therefore, at present, no effective vaccine or antiviral agent against the cold virus has been developed, and pharmacotherapy for the cold syndrome is mainly symptomatic treatment. Antipyretic analgesics are often used in the treatment of such cold syndrome for the purpose of reducing fever, headache, myalgia, pharyngitis, chills and the like which are typical syndromes of cold.

[0003] However, such antipyretic analgesics have a bitter taste when taken, so that the cold remedy has a problem of poor feeling of taking, particularly from the viewpoint of compliance.

On the other hand, Echinacea
Is a kind of herb native to the North American continent and is commonly used as an immunostimulant in the form of powders, solids, extracts, tea, etc., mainly in Europe for the purpose of preventing colds and improving cold symptoms. There is a crude drug.

[0005] However, there is no known prescription in which echinacea is mixed with a remedy for a cold syndrome containing an antipyretic analgesic for the purpose of improving the feeling of taking.

[0006]

DISCLOSURE OF THE INVENTION The present invention has been made in view of the above-mentioned problems of the prior art, and has as its object the purpose of containing an effective amount of an antipyretic analgesic and excellent in taking feeling. An object of the present invention is to provide a composition for treating a cold syndrome with improved compliance.

[0007]

Means for Solving the Problems The present inventors have conducted intensive studies on the prescription of a symptomatic treatment for wind syndrome in order to solve the above-mentioned problems. As a result, the present inventors have applied Echinacea to a treatment for cold syndrome containing an antipyretic analgesic. The inventor has found that the blending significantly improves the feeling of taking and completed the present invention.

[0008] That is, the present invention is a composition for treating a cold syndrome comprising an echinacea and an antipyretic analgesic.

The present invention also provides the composition for treating cold syndrome, wherein the compounding ratio is 0.1 to 50 parts by weight of the antipyretic analgesic to 1 part by weight of echinacea.

The present invention further provides the composition for treating a cold syndrome, wherein the antipyretic analgesic is at least one selected from the group consisting of acetaminophen, ibuprofen, etensamide and isopropylantipyrine.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Echinacea used in the composition for treating a cold syndrome of the present invention includes plant echinacea purpurea, and echinacea angstifolia.
angustifolia), Echinacea-Parida (E
chinacea pallida), Echinacea paradoxa (Echinacea paradoxa),
Echinacea-Echinacea
tennesseeensis), Echinacea sanguinea (Echinacea sanguinea), Echinacea-simurata (Echinacea simul)
ata) and Echinacea-Atrolbens (Echi
extract or a crude drug powder extracted from these related crude drugs or an isolated form of one of these components, and these can be used alone or in combination of two or more.

[0012] The echinacea is one of the European herbs, which is widely used especially in Germany.
sco, Madaus, Nattermann,
It is generally obtained from Schaper & Bruemmer.

The antipyretic analgesic used in the composition for treating a cold syndrome of the present invention includes acetaminophen, aspirin, etensamide, sazapyrine, salicylamide, sulpyrine, indomethacin, diclofenac sodium, ibuprofen, ketoprofen, mefenamic acid,
Aluminum flufenamic acid, epilizol, tiaramid hydrochloride, tinolizine hydrochloride, tolmetin sodium, pranoprofen, fenoprofen calcium, isopropylantipyrine and the like.
More than one species can be used. Among them, when acetaminophen, ibuprofen, etensamide and isopropylantipyrine are used, the effect of improving the feeling of taking is particularly large.

In order to use the composition for treating a cold syndrome of the present invention as a remedy for a cold syndrome, in addition to adding echinacea and an antipyretic analgesic, if necessary, an antihistamine drug, an anti-inflammatory enzyme drug, a bronchodilator drug Antitussives, expectorants, anticholinergics,
Drugs such as caffeine, vitamins, crude drugs, and antacids can be appropriately compounded.

The antihistamines include diphenhydramine, chlorpheniramine, diphenylpyramine,
Isotipendyl, promethazine, alimemazine, mequitazine, dipheterol, tripelenamine, tondiamine, phenetazine, metrazine, cyproheptadine, carbinoxamine, clemastine, and the like, and salts thereof, and these salts can be used alone or in combination of two or more.

Examples of the anti-inflammatory enzyme include serrapeptase, bromelain, proctase, pronase, semi-alkaline proteinase, streptokinase, lysozyme chloride and related substances, and these can be used alone or in combination of two or more.

The bronchodilators include epinephrine, isoproterenol, orciprenaline, chlorprenaline, trimethokinol, salbutamol, terbutaline, hexoprenaline, procaterol, tulobuterol, pirbuterol, fenoterol, formoterol, clenbuterol, mabuterol, theophylline, aminophylline, theophylline, aminophylline, aminophylline, theophylline, aminophylline, and theophylline. Choline theophylline, diprofylline and the like can be mentioned, and these can be used alone or in combination of two or more.

Examples of the antitussives include codeine, dihydrocodeine, ephedrine, noscapine, dextromethorphan, dimemorphan, epradinone, benproproperine, tipepidine, cloperastine, clofedanol, hominoben, guaifenesin, carbetapentane and the like. And these may be used alone or in combination of two or more.

The expectorants include bromhexine, N
-Acetyl-L-cysteine, L-methylcysteine,
Examples thereof include L-ethylcysteine, carbocysteine, ambroxol and the like, and salts thereof, and these may be used alone or in combination of two or more.

The anticholinergic agents include ipratropium, flutropium, oxitropium and the like.
These can be used alone or in combination of two or more.

The above-mentioned caffeine includes caffeine and anhydrous caffeine.

The vitamins include vitamin B ₁ ,
Vitamin B ₂ , vitamin C, and the like, and derivatives thereof, and salts thereof, may be used alone or in combination of two or more.

[0023] The crude drugs include midsummer, spicy, garbage,
Ginger, licorice, saiko, cinnamon bark (branch), (purple) soba, mako, shakuyaku, gomiko, yellow bon, river cucumber, ground yellow, yellow ren, bellflower, wheat gate winter, renchi, spicy, choji, uika , Eucalyptus, lavender, herbal powders such as light loads, extracts thereof, and the like, and these can be used alone or in combination of two or more.

Examples of the antacid include crude sodium carbonate, calcium carbonate, magnesium oxide, dried aluminum hydroxide gel, magnesium hydroxide and the like, and these can be used alone or in combination of two or more.

These components can be used alone or in admixture with each other.
It is compounded in accordance with the standards for cold medicines and the like listed in the 1995 edition of Pharmaceutical Times.

The composition for treating a cold syndrome of the present invention comprises a general cold remedy, an antipyretic analgesic,
It can be used in a wide variety of forms such as antitussive expectorants, rhinitis drugs, cold preventives, immunostimulants and health foods.

In the composition for treating a cold syndrome of the present invention, the mixing ratio of the above-mentioned echinacea to the antipyretic analgesic is as follows.
The antipyretic analgesic is preferably 0.1 to 50 parts by weight, more preferably 1 to 30 parts by weight based on parts by weight. If the compounding ratio exceeds the upper limit, the effect of improving the feeling of taking by adding echinacea cannot be obtained,
If the amount is less than the lower limit, the effect of improving the feeling of ingestion corresponding to the added amount of echinacea cannot be obtained, and neither is preferable. In particular, the compounding ratio of the antipyretic analgesic to 1 part by weight of echinacea is 0.3 to 50 parts by weight for acetaminophen, 0.1 to 50 parts by weight for ibuprofen, and 0.2 to 50 parts by weight for etenzamide.
0.1 for 50 parts by weight and isopropylantipyrine
~ 50 parts by weight are preferred.

The effective amount of the echinacea in the therapeutic agent for cold syndrome of the present invention is 25 mg to 100 mg / day for healthy adults.
0 mg (equivalent amount of crude drug 1 g to 40 g), preferably 50 mg to 750 mg (equivalent amount of crude drug 2 g to 30 g)
Is good.

The effective amount of the antipyretic analgesic in the therapeutic agent for cold syndrome of the present invention is 100 mg / day for healthy adults.
~ 1200 mg, preferably 150 mg ~ 900
mg is better.

The composition for treating a cold syndrome of the present invention can be prepared by a conventional method as a preparation for oral administration. To make the composition for treating a cold syndrome of the present invention into a solid preparation,
Suitable additives, for example, excipients such as lactose, sucrose, mannitol, corn starch, synthetic or natural gum, crystalline cellulose, binders such as starch, cellulose derivatives, gum arabic, gelatin, polyvinylpyrrolidone, carboxy Disintegrants such as methylcellulose calcium, sodium carboxymethylcellulose, starch, corn starch, sodium alginate, lubricants such as talc, magnesium stearate, sodium stearate, fillers such as calcium carbonate, sodium carbonate, calcium phosphate, sodium phosphate or Tablets, powders (powder), pills, granules and the like can be appropriately mixed with a diluent and the like. Further, capsules may be prepared using hard or soft gelatin capsules or the like. These solid preparations may be provided with an enteric coating using a coating base such as hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, cellulose acetate phthalate, methacrylate copolymer and the like.

In order to make the composition for treating cold syndrome of the present invention into a liquid preparation, it is dissolved in a generally used inert diluent such as purified water and the like, and if necessary, an infiltrant or an emulsifier is added to this solution. , Dispersing aids, dissolution aids such as surfactants, preservatives,
A syrup, an elixir, a liquid for internal use, and the like can be prepared by appropriately adding a flavor, a pigment, a sweetening agent / flavoring agent, a coloring agent, and the like.

When the composition for treating a cold syndrome of the present invention is administered as a drug, it is usually possible to orally administer 300 to 1500 mg of the active ingredient per day to an adult in one or several divided doses. . This dose can be appropriately adjusted depending on the age, weight, and medical condition.

[0033]

EXAMPLES Hereinafter, the composition for treating a cold syndrome of the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

Example 1 Acetaminophen 900 g Dihydrocodeine phosphate 24 g Methylephedrine hydrochloride 60 g Chlorpheniramine maleate 6 g Echinacea soft extract 24 g Guaifenesin 125 g Anhydrous caffeine 50 g Lactose 275 g Low-substituted hydroxypropylcellulose 275 g Magnesium stearate 35 g Hardened Castor oil 26 g After weighing and uniformly mixing each component in the above-mentioned formulation, the obtained mixed powder was weighed 300 m / tablet by a direct compression method.
g to obtain 6000 tablets.

Example 2 Acetaminophen 900 g Codeine phosphate 18 g Methylephedrine hydrochloride 60 g Carbinoxamine maleate 12 g Echinacea soft extract 24 g Guaifenesin 125 g Anhydrous caffeine 50 g Lactose 275 g Low-substituted hydroxypropyl cellulose 275 g Magnesium stearate 32 g Hardened castor oil 29 g After weighing and uniformly mixing each component in the above formulation, the obtained mixed powder was weighed 300 m / tablet by a direct compression method.
g to obtain 6000 tablets.

Example 3 Ibuprofen 450 g Benproperin phosphate 30 g Methylephedrine hydrochloride 60 g Carbinoxamine maleate 12 g Echinacea soft extract 24 g Guaifenesin 125 g Lactose 374 g Low-substituted hydroxypropyl cellulose 350 g Magnesium stearate 40 g Hardened castor oil 35 g each of the above castor oil Are weighed and mixed uniformly, and the obtained mixed powder is weighed 300 m / tablet by a direct compression method.
g to obtain 5000 tablets.

(Comparative Test for Taking Feeling) The feeling of taking the composition for treating a cold syndrome of the present invention was sensory evaluated by a blind test.

According to the formulations shown in Table 1, the composition for treating cold syndrome of the present invention (test drugs 1 and 2), echinacea soft extract alone (control drug 1), acetaminophen alone (control drug 2) and ibuprofen alone (Control 3) were each prepared as a powder. Echinacea is Natt
ermann (Germany), 3.0 g of crude drug equivalent was used. The test drugs 1 and 2 and the control drugs 1 to 3 were taken by 20 people suffering from a cold, and the feeling of taking each drug was evaluated. In addition, evaluation was made into four grades of "A: very easy to drink", "B: easy to drink", "C: Neither can be said", and "D: difficult to drink", and it compared with the evaluation number of B or more. Table 2 shows the results.

[0039]

[Table 1]

[0040]

[Table 2]

As is evident from the results in Table 2, it can be seen that the composition for treating a cold syndrome of the present invention significantly improves the feeling of taking as compared with the case where echinacea and an antipyretic analgesic are taken alone.

[0042]

EFFECT OF THE INVENTION Since the composition for the treatment of cold syndrome of the present invention comprises an echinacea and an antipyretic analgesic, it is excellent in feeling of taking while having an effective amount of an antipyretic analgesic and has improved compliance. An agent for treating a syndrome can be obtained.

Further, the composition for treating a cold syndrome of the present invention comprises echinacea and an antipyretic analgesic.
It is effective in alleviating fever, headache, myalgia, pharyngitis, chills, etc., which are typical syndromes of colds, and is also extremely effective in improving various symptoms of colds by preventing immunity and preventing secondary infection. .

The composition for treating a cold syndrome of the present invention further comprises an antihistamine, an anti-inflammatory enzyme, a bronchodilator, an antitussive, an expectorant, an anticholinergic, a caffeine, a vitamin, a crude drug and Since it contains at least one drug selected from the group consisting of antacids, it can be used as a prescription drug or cold medicine for various symptoms of cold, and is useful as a therapeutic agent for various cold syndromes .

Claims (3)

[Claims] 1. A composition for treating a cold syndrome comprising an echinacea and an antipyretic analgesic. 2. The composition for treating a cold syndrome according to claim 1, wherein the compounding ratio is 0.1 to 50 parts by weight of the antipyretic analgesic to 1 part by weight of echinacea. 3. The antipyretic analgesic, acetaminophen,
The composition for treating a cold syndrome according to claim 1 or 2, wherein the composition is at least one selected from the group consisting of ibuprofen, etensamide and isopropylantipyrine.