JPH10287550A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a weakly irritant preparation for external use for skin, effective for treatment of atopic dermatitis, by using a biological ingredient(s) as a moisturizing ingredient(s) and making its (their) compounding amount(s) as small as possible, and also, adjusting the pH of the preparation at the same level as that of the healthy skin. SOLUTION: This preparation contains moisturizing ingredient(s) (0.1-20 wt.%), an electrolyte ingredient (0.02-1.0 wt.%) and pH-adjustor(s) (0.1-1.0 wt.%). As the moisturizing ingredient(s), one or more kinds are preferably selected from the group consisting of saccharides (preferably, glucose, lactose, etc.), polyhydric alcohols (preferably, glycerol), high molecular polymers (preferably, polyethylene glycol polymers), polysaccharides (preferably, hyaluronic acid, chondroitin sulfate, etc.) and/or salts thereof. As the electrolyte component, sodium chloride, calcium chloride, etc., is preferable. As the pH-adjustor(s), one or more kinds are preferably selected from phosphoric acid, sodium phosphate, citric acid and sodium citrate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin, and more particularly, to an external preparation for sensitive skin such as atopic dermatitis.

[0002]

2. Description of the Related Art Recently, atopic dermatitis has been increasing in adults after childhood due to changes in living environment and dietary habits.

[0003] The causes of adult atopic dermatitis are still largely unknown, and in addition to abnormalities in the immune system, a decrease in skin barrier functions such as dry skin has been observed.

[0004] In general, creams containing a humectant, vaseline, and the like are used in addition to various anti-inflammatory agents for such symptoms.

[0005]

However, in some patients, these oily bases cause incompatibility such as "itching" and "redness".

A lotion containing strong acid water or an anti-inflammatory agent is also used, but it is not preferable in terms of skin safety due to strong acidity and irritation of the drug itself.

[0007] The present invention has been made to solve such problems, and has as its object to provide a hypoallergenic topical skin preparation useful for preventing or improving symptoms of atopic dermatitis.

[0008]

That is, in order to solve the above-mentioned problems, the present invention uses a biological component as a compounding component of an external preparation for skin, suppresses the compounding amount as small as possible, and adjusts the pH to a normal level. The focus was on making the same adjustment as the skin.

The present inventors focused on the pH of the skin and the number of staphylococci in the skin, and measured the pH of the skin, the severity of the eruption and the number of staphylococci in the skin of patients with atopic dermatitis, and compared them with those of healthy individuals. .

[0010] As a result, it has been found that in patients with atopic dermatitis, the skin pH is higher than in healthy subjects, which is proportional to the severity of the eruption and the number of Staphylococcus aureus on the skin surface. Was. Tables 1 and 2 show the measurement results.

[0011]

[Table 1]

[0012]

[Table 2]

From the above new findings, it has been found that an external preparation for skin having a pH similar to that of healthy skin, having a composition close to that of the body's sweat, and having low sensitizing and irritating properties can improve the symptoms of atopic dermatitis. Thus, the present invention has been completed.

That is, the external preparation for skin of the present invention contains 0.1-20% by weight of a moisturizing component and 0.02-1.
It is characterized by containing 0% by weight and 0.1 to 1.0% by weight of a pH adjuster.

Examples of the moisturizing component include polyhydric alcohols such as glycerin, macromolecules such as polyethylene polymers, monosaccharides or disaccharides such as glucose, lactose and maltose, polysaccharides such as hyaluronic acid and chondroitin sulfate, and electrolytes. Components include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium salts, and examples of pH adjusters include phosphoric acid, citric acid, and salts thereof.

From the characteristics of the skin function of atopic dermatitis,
Since the use of the same component as the living body as a moisturizing component suppresses the reaction to irritation and foreign substances (antigen), and the amount of the compounding component needs to be as small as possible, the preferable compounding amount of such a moisturizing component is 0.1 １５15% by weight.

The pH adjusting agent, which is another essential component of the external preparation for skin of the present invention, is phosphoric acid, citric acid and salts thereof.
1-0.5 wt% and 0.2-1.0 wt%, pH
Is adjusted to 4.0 to 4.5, preferably 4.2 to 4.4.

[0018]

According to the present invention, the use of a pH close to that of healthy skin for atopic dermatitis gives the original skin cleansing ability of healthy skin, suppresses the growth of S. aureus dermatitis, and gives the skin an appropriate It has an effect of giving a good moisture and moisturizing and improving the symptoms of atopic dermatitis.

In order to obtain the effect of the external preparation for skin of the present invention, the topical lotion of the present invention may be applied several times a day, preferably 4 to 5 times, to a site where inflammation occurs and the vicinity thereof.

[0020]

Embodiments of the present invention will be described below.

Example 1 In this example, a lotion was prepared based on the following formulation. Specifically, after completely dissolving the A component in 19.3 parts by weight of water and the B component in 67.95 parts by weight of water, B was gradually added to A and stirred to obtain a lotion. In addition, the numerical value of each component represents a weight part.

Test Example 1 The lotion of Example 1 was used for atopic dermatitis patients, and the effectiveness of the lotion was compared with the drugs used by the patients.

The test was conducted on 59 patients with atopic dermatitis. The face was divided into left and right sides, and the lotion of Example 1 was applied externally to one of the left and right sides. And the patient determined the effective difference between the two.

The determination of the difference in efficacy was performed by a single blind test method in which the attending physician determined the efficacy without knowing which drug the patient was using.

The test results are shown in Tables 3 and 4 below. Table 3 shows the judgment results of the attending physician, and Table 4 shows the judgment results of the patient.
Are shown below.

[0026]

[Table 3]

[0027]

[Table 4]

From the test results, the lotion of the present invention was
The efficacy was higher than that of the conventional treatment, and the attending physician's judgment revealed a statistically significant difference in moderate atopic dermatitis at a significance level of 5%. In addition, in the judgment of the patients, there was a significant difference of 1% between severe and moderate atopic dermatitis.

[0029]

As described above, the external preparation for skin of the present invention comprises:
Atopy characterized by high skin pH and high levels of indigenous bacteria such as Staphylococcus aureus on human skin to restore the skin barrier function by supplementing the moisturizing function of the skin and adjusting the skin to the original pH of a healthy person. Dermatitis can be improved more effectively than conventional treatment methods.

Claims (8)

[Claims] A humectant component of 0.1 to 20% by weight, an electrolyte component of 0.02 to 1.0% by weight, and a pH adjuster of 0.1 to 20% by weight.
An external preparation for skin characterized by containing 1.0% by weight. 2. The moisturizing component is a saccharide, a polyhydric alcohol,
1 selected from a polymer, a polysaccharide and / or a salt thereof
2. The external preparation for skin according to claim 1, which is at least one kind. 3. The external preparation for skin according to claim 2, wherein the saccharide is at least one selected from glucose, lactose and maltose. 4. The external preparation for skin according to claim 2, wherein the polyhydric alcohol is glycerin. 5. The external preparation for skin according to claim 2, wherein the high polymer is a polyethylene glycol high polymer. 6. The external preparation for skin according to claim 2, wherein the polysaccharide is at least one selected from hyaluronic acid, chondroitin sulfate, and chitin. 7. The external preparation for skin according to claim 1, wherein the electrolyte component is at least one selected from sodium chloride, calcium chloride, and magnesium chloride. 8. The external preparation for skin according to claim 1, wherein the pH adjuster is at least one selected from phosphoric acid and sodium phosphate, citric acid, and sodium citrate.