JPH1028550A - Nutritive composition for hepatopathic patient - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of being taken for a long period of time, easy to be taken in terms of flavor or texture, and useful for a long-term alimentary therapy for reduction and recovery of hepatopathic disease symptoms by containing ethanolamine derived from a plant (preferably a fruit). SOLUTION: This nutritive composition contains ethanolamine derived from a plant, preferably from a fruit (a pineapple, a mandarin orange, an orange, a lemon, a lime, an apple, grapes a each, a persimmon, a kiwi fruit, etc.) in an amount of 10-800μg (preferably 100-500μg) per 1kcal. When taking the composition daily in an amount of 1,500kcal, about 150-750mg of ethanolamine is digested for a long period of time and a sufficient effect on recovery from hepatopatic disease is expected.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to a nutritional composition for patients with liver disease, which comprises a plant-derived ethanolamine.
The present invention relates to a nutritional composition for liver disease patients, which comprises fruit-derived ethanolamine. The nutritional composition according to the present invention can be used as such, and can be used as a nutritional composition widely used in general, and a nutritional composition comprising ethanolamine derived from a natural plant, It can be widely used for patients with reduced levels and also for healthy people for its prevention or health.

[0002]

BACKGROUND OF THE INVENTION Diet therapy for patients with impaired liver function is based on a diet of high energy and high protein composition. In addition, since abnormalities in amino acid metabolism are observed in liver failure, dietary treatment considering the amino acid composition is required to correct the imbalance of plasma free amino acids.

[0003] The mechanism of hepatic encephalopathy that characterizes hepatic failure is characterized by abnormal plasma free amino acid patterns in severe liver injury, in particular, a decrease in branched-chain amino acids and an increase in aromatic amino acids, tryptophan, and methionine. Thus, it has been clarified that abnormalities in amine metabolism in the brain resulting from this disorder in the plasma free amino acid pattern are the main cause of hepatic encephalopathy. The decrease in blood branched-chain amino acids during hepatic failure is due to the fact that insulin increased by liver injury increases the uptake of branched-chain amino acids in muscle tissue and adipose tissue, and increases in blood aromatic amino acids and tryptophan It is thought to be due to increased protein catabolism in the liver and muscle, a decrease in the ability of the liver to synthesize proteins, and a decrease in the ability of the liver to treat aromatic amino acids and tryptophan. Therefore, preparations for liver failure are composed of free amino acids in which the proportion of branched-chain amino acids is significantly higher than that of aromatic amino acids.

In severe liver diseases such as cirrhosis, abnormalities in lipid metabolism are observed, and deficiencies of polyunsaturated fatty acids, particularly arachidonic acid and DHA in phospholipids, have been reported. Phospholipids are mainly synthesized in liver microsomes and are present in serum as lipoproteins. It is widely believed that the decrease in phospholipid concentration and the abnormality of constituent fatty acids are due to a decrease in synthetic ability in the liver. Phospholipids are also important in the gastric mucosal defense function. Since lipids account for more than half of the energy utilization rate during cirrhosis, it has been attempted to supplement phospholipids with fat emulsions and add arachidonic acid and DHA as nutritional supplements. ing.

[0005]

The conventional nutritional composition for liver disease is intended to maintain or reduce liver damage by correcting imbalance of various nutrients in patients with liver disease. The purpose of the present invention is to newly develop an excellent nutritional composition containing components that actively reduce and repair liver damage and that can be used in a long-term diet.

[0006]

Means for Solving the Problems As a result of diligent studies from various angles to solve the above-mentioned problems, it has been found that the intraperitoneal administration and the oral administration of ethanolamine significantly reduce the serum transaminase in rats with carbon tetrachloride-induced liver injury. The effect of repairing the disorder was observed, and the area of the necrosis portion of the liver histopathological image was reduced (Japanese Patent Application No. 8-61).
599), and discovered for the first time that it is possible to develop a nutritional composition excellent in long-term dietary nutritional supplementation during liver injury.

[0007] Ethanolamine exists widely in nature and is known to be necessary for living organisms as a signal transmission system substance. No toxicity was recognized from the results of the acute toxicity test (Japanese Patent Application No. 8-61599). Ethanolamine has a molecular weight of 61.08, which is a very advantageous substance in its absorption ability even when administered orally. Also, about 8 μg of ethanolamine is contained per 1 ml of milk. However, ethanolamines are generally known as amines as a product of spoilage of fish and meat,
Does not meet the needs of consumers in terms of safety.

[0008] In view of the above, since ethanolamine itself is very effective as described above, it was recognized that it was necessary to develop a nutritional composition particularly suitable for patients with liver disease while taking advantage of its effectiveness. Can be taken over a long period of time, so it has no off-flavors, off-flavors, etc., and is easy to take in terms of flavor and texture. It was recognized that there was a need to develop a composition that could satisfy all aspects of processability.

[0009] First, attention was paid to ethanolamine derived from natural products, and as a result of examining ethanolamine sources capable of satisfying the above requirements from various fields, plants were effective as a source of ethanolamine derived from natural products. As a result of repeated studies on the content, they have found that they are present at high levels, especially in plants, preferably fruits. In addition, they found that it was more effective to use fruits as a source from the viewpoint of safety of coexisting substances.
The content was measured by an amino acid analysis method at an excitation wavelength of 340 nm and a fluorescence wavelength of 455 nm according to a conventional method.

Further, as a result of studying the content of ethanolamine, the following was found, and the present invention was completed. In other words, regarding the content of ethanolamine,
Nutritional composition according to the present invention is 10-800μ per 1 kcal
g, more desirably, 100-500 μg ethanolamine, so that when taken 1500 kcal a day, 150-750 mg ethanolamine can be taken for a long period of time, which is expected to have a sufficient effect on repairing liver damage. It is.

In the present invention, ethanolamine derived from a plant (preferably a fruit) is used. As the ethanolamine, it is a matter of course that a purified product which has been sufficiently purified is used. The product, the inclusion or the processed product can be used freely. As the ingredients, all plant-derived substances containing ethanolamine, such as squeezed liquids of plants (fruits), can be used, and the processed products are obtained by various treatments such as concentrated to pasted to dried products. Those that have been used can be used as appropriate.

As the plants, plants containing ethanolamine are widely used, and for example, one or more vegetables and fruits are suitably used. As vegetables, besides leaf vegetables such as spinach and komatsuna, root vegetables such as carrot, radish and burdock, potatoes and the like are appropriately used. As fruits, various fruits such as pineapple, mandarin orange, orange, lemon, lime, apple, grape, peach, oyster and kiwi are widely used.

In the present invention, the above-mentioned nutritional composition may be taken by a liver diseased person as it is, but better results can be obtained when other food ingredients are used in combination. Other food components include protein sources, carbohydrate sources, and / or lipid sources, and other components may be added as necessary to form liquid-to-paste-to-solid food and drink-type compositions. can do.

As the protein source in the present composition, animal and vegetable proteins, as well as their hydrolysates and crystalline amino acids can be used. There are no particular restrictions on the proportion of each ingredient used as a protein source, but animal proteins include milk, eggs, meat, chicken,
Animal-derived proteins obtained from fish meat and the like are used, and as vegetable proteins, wheat, soybeans,
Plant-derived proteins obtained from rice, corn and the like are used. As the hydrolyzate, a low-molecular peptide excellent in absorption in the intestinal tract can be considered, and more preferably, a hydrolyzate containing a large amount of branched-chain amino acids and having a high Fischer ratio is effective in expecting an effect on liver disease. As crystalline amino acids, L-arginine, branched-chain amino acids, other essential amino acids, and the like, whose effectiveness is generally recognized, can be used, and are not particularly limited. Further, by preparing a composition with a reduced protein content and using it simultaneously with a high-Fisher-ratio preparation that has already been prepared, further effects are expected for patients with liver disease.

As the carbohydrate source in the present composition, fructose, lactulose, glucose, dextrin, lactose and the like can be used. Although the content is not particularly limited, it is desirable to supply 50 to 65% from the saccharide in terms of the energy ratio.

As a lipid source, vegetable oil, fish oil, animal oil and the like can be used, and it is desirable to enhance EPA, DHA, arachidonic acid, linolenic acid and the like as fatty acids contained therein. The energy ratio of the lipid is preferably 20 to 30%. Further, as an emulsion stabilizer, lecithin derived from a plant and egg yolk can be used.

Hereinafter, production examples of the composition of the present invention will be described.

[0018]

[Production Example 1] Pine apple (from Hawaii) edible part 2
Squeeze 000 kg to obtain fruit juice. The obtained juice is filtered with a filter having a mesh size of 106 μm. The filtrate was supplied to a concentrator and concentrated by heating under reduced pressure to obtain a concentrated pineapple juice containing 2150 mg of ethanolamine per 1 kg. Next, a composition effective for a liver disease patient was produced according to a conventional method according to the composition shown in Table 1 below.

[0019]

[Table 1]

The composition prepared is adjusted to 1 kcal per 1 ml, and if a liver diseased person drinks 1500 ml per day, it is possible to take about 300 mg of ethanolamine.

[0021]

[Production Example 2] 200 kg of commercially available Unshu mandarin oranges (produced in Saga Prefecture) (whole fruits such as pulp, joyou, albedo and flavedo) are crushed and immersed in 2,000 liters of warm water with stirring all day and night. Filter with a filter. This filtrate was supplied to a concentrator and concentrated by heating under reduced pressure to obtain a concentrated raw material containing 4620 mg of ethanolamine per kg. Next, a composition effective for a liver disease patient was produced according to a conventional method according to the composition shown in Table 2 below.

[0022]

[Table 2]

The prepared composition is adjusted to 1 kcal per 1 ml, and if a liver diseased person drinks 1500 ml per day, it is possible to take about 750 mg of ethanolamine.

[0024]

According to the present invention, by containing ethanolamine as one of the active ingredients, the quality of Q
It can sufficiently cope with long-term nutritional treatment (reduction of GOT value and GPT value and regeneration of damaged cells) that respects OL, and can also be expected to have a sufficient effect of preventing liver disease in healthy subjects.
The ethanolamine contained is derived from a natural product, and can be safely and effectively treated for a long term without side effects in treating liver diseases.

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Yu Kuwata 1-21-3 Sakaecho, Higashimurayama-shi, Tokyo Meiji Dairies Co., Ltd.

Claims (3)

[Claims] 1. A nutritional composition for patients with liver disease, comprising 10-800 μg of ethanolamine obtained from a plant, preferably a fruit, per 1 kcal. 2. The composition according to claim 1, wherein the ethanolamine is ethanolamine itself and / or a content thereof. 3. The composition according to claim 2, wherein the ethanolamine-containing substance is a concentrate of a vegetable juice, preferably a fruit juice and / or a processed product thereof.