JPH10263072A - Member for medical instrument and medical instrument - Google Patents

Member for medical instrument and medical instrument

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Publication number
JPH10263072A
JPH10263072A JP9076165A JP7616597A JPH10263072A JP H10263072 A JPH10263072 A JP H10263072A JP 9076165 A JP9076165 A JP 9076165A JP 7616597 A JP7616597 A JP 7616597A JP H10263072 A JPH10263072 A JP H10263072A
Authority
JP
Japan
Prior art keywords
ethylene
copolymer
polyvinyl chloride
polystyrene
polyolefin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9076165A
Other languages
Japanese (ja)
Inventor
Osami Shinonome
修身 東雲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP9076165A priority Critical patent/JPH10263072A/en
Publication of JPH10263072A publication Critical patent/JPH10263072A/en
Pending legal-status Critical Current

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  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

PROBLEM TO BE SOLVED: To exhibit a satisfactory adhering effect by making a polyvinyl chloride molding and a polyolefin molding adhere to each other through a polymer composition such as epoxidated styrene elastomer, ethylene-vinyl acetate cipolymer, ethyleneester acrylate copolymer or the like. SOLUTION: An infusion container 1 which is a polyvinyl chloride molsinf is manufactured in such a manner that its discharge port 2 is made adhere to a discharge port fitting prt of an infusion container main body 3 which is a polyolefin molding. At this time, as an adhesive, used is a film formed by a polymer composition of epoxydated styrene elastomer, ethylene-vinyl acetate copolymer, ethylen ester acrylate copolymer or ethylene ester methacrylate. The epoxydated styrene elastomer used is preferably an epoxy compound of a block copolymer of polystyrene and polybutadiene or a block copolymer of polystyrene and polyisoprene.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【0001】[0001]

【産業上の利用分野】本発明は血液関係、医薬液関係等
の医療分野における容器、液体搬送用チューブ、コネク
ター、人工臓器等の器具に使用されるプラスチック部材
およびそれを用いた医療器具に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a plastic member used for instruments such as containers, liquid transport tubes, connectors and artificial organs in the medical field such as blood-related and medical fluid-related fields, and a medical instrument using the same.

【0002】[0002]

【従来の技術】採血・輸血や輸液をはじめ、医療分野に
おいて用いられるプラスチック製の器具には安全性・衛
生性の他種々の性能が要求される。ポリ塩化ビニルは可
塑剤の量を調節することによって、剛性・柔軟性、透明
性、耐熱性(耐滅菌性)などをコントロールできるの
で、バッグ、チューブ、ジョイント、排出口など従来か
らこれらの分野に広く利用されているが、廃棄処理など
において問題を生じることがあり、エチレン主成分ポリ
マー、プロピレン主成分ポリマーなど塩素を含有しない
オレフィン系ポリマーへの移行が進んでいる。しかしな
がら、オレフィン系ポリマーでは剛性・柔軟性、透明
性、耐熱性などの巾が狭いため、ポリ塩化ビニルの使わ
れている領域をカバーできないのも現状である。例えば
排出口、ジョイント、チューブなどではポリ塩化ビニル
に代り得るポリオレフィン材料がないことがしばしばあ
り、結局はポリ塩化ビニルに頼らざるを得ないことが多
い。現在はポリオレフィン化できる部材は「できるだ
け」ポリオレフィン化し、ポリ塩化ビニル製の部分を極
力減らすということに重点が置かれている。
2. Description of the Related Art Plastic instruments used in the medical field, such as blood collection, blood transfusion and infusion, are required to have various performances in addition to safety and hygiene. Polyvinyl chloride can control rigidity, flexibility, transparency, heat resistance (sterilization resistance), etc. by adjusting the amount of plasticizer. Although widely used, they may cause problems in waste treatment and the like, and the transition to olefin-based polymers containing no chlorine, such as ethylene-based polymer and propylene-based polymer, is in progress. However, since olefin polymers have narrow widths such as rigidity / flexibility, transparency and heat resistance, it is impossible at present to cover the area where polyvinyl chloride is used. For example, at outlets, joints, tubes, etc., there is often no polyolefin material that can substitute for polyvinyl chloride, and ultimately one has to resort to polyvinyl chloride. At present, emphasis is placed on making polyolefins "as much as possible" and minimizing parts made of polyvinyl chloride.

【0003】この場合問題になるのは親和性に乏しいポ
リマー成形品の接合である。すなわち、ポリ塩化ビニル
とポリオレフィンは通常接着・融着することができず、
ポリ塩化ビニルを使用する必要のない部分へのポリオレ
フィンの適用が非常に困難であるため、その展開が大巾
に制限されることになっているからである。ポリエチレ
ンやポリプロピレンにカルボキシル基、エポキシ基など
を導入した、いわゆる接着性ポリマーをポリ塩化ビニル
製部材とポリオレフィン部材との間に介在させる構成も
提案されているが、十分な接着効果を発揮しないのが実
状である。
[0003] In this case, the problem is the joining of polymer molded articles having poor affinity. In other words, polyvinyl chloride and polyolefin cannot usually be bonded and fused,
This is because it is very difficult to apply a polyolefin to a portion where it is not necessary to use polyvinyl chloride, so that its development is to be greatly restricted. A configuration has been proposed in which a so-called adhesive polymer in which a carboxyl group, an epoxy group, or the like is introduced into polyethylene or polypropylene is interposed between a polyvinyl chloride member and a polyolefin member. It is a fact.

【0004】[0004]

【発明が解決しようとする課題】上記状況に鑑み、本発
明の課題はポリオレフィン製の成形品とポリ塩化ビニル
からなる成形品とを一体化(接着)できる技術を確立
し、ポリオレフィン系成形品とポリ塩化ビニル系成形品
とが一体化した医療器具用部材およびそれを用いた医療
器具を提供することにある。
SUMMARY OF THE INVENTION In view of the above situation, an object of the present invention is to establish a technique for integrating (adhering) a molded article made of polyolefin and a molded article made of polyvinyl chloride, and to form a polyolefin-based molded article. It is an object of the present invention to provide a medical device member integrated with a polyvinyl chloride-based molded article and a medical device using the same.

【0005】[0005]

【課題を解決するための手段】本発明の要旨は、エポキ
シ化スチレン系エラストマー(A)とエチレン酢酸ビニル
コポリマー、エチレンアクリル酸エステルコポリマーも
しくはエチレンメタクリル酸エステルコポリマー(B)と
の重合体組成物(C)を介して、ポリ塩化ビニル系成形品
(D)とポリオレフィン系成形品(E)とが接着されてなる医
療器具用部材、および該部材を構成要素とする医療器具
であり、(A)と(B)とが比較的相溶性の良い重合体組成物
(C)を形成し、この(C)が(D)と(E)とのいずれに対しても
良好な親和性を有し、医療分野で通常行われる高圧蒸気
滅菌処理においても接着力が保たれることにある。そし
て、上記(A)がポリスチレンとポリブタジエンとのブ
ロックコポリマーもしくはポリスチレンとポリイソプレ
ンとのブロックコポリマーのエポキシ化物であることが
好ましい。また、上記(E)がポリエチレン、ポリプロ
ピレンもしくはポリブテン−1からなる成形品であるこ
とが好ましい。
The gist of the present invention is to provide a polymer composition of an epoxidized styrene elastomer (A) and an ethylene vinyl acetate copolymer, an ethylene acrylate ester copolymer or an ethylene methacrylate ester copolymer (B). Through C), PVC molded products
(D) and a polyolefin-based molded article (E) is a member for a medical device that is adhered, and a medical device having the member as a component, (A) and (B) are relatively compatible Polymer composition
(C), which has a good affinity for both (D) and (E), and retains its adhesive strength even in the high-pressure steam sterilization treatment usually performed in the medical field. To be drowned. It is preferable that (A) is an epoxidized product of a block copolymer of polystyrene and polybutadiene or a block copolymer of polystyrene and polyisoprene. Further, it is preferable that the above (E) is a molded article composed of polyethylene, polypropylene or polybutene-1.

【0006】[0006]

【発明の実施の形態】本発明におけるエポキシ化スチレ
ン系エラストマー(A)としては、ポリスチレンとポリブ
タジエンとのブロックコポリマー(通常はポリスチレン
−ポリブタジエン−ポリスチレン型のトリブロックコポ
リマーであり、SBSと呼ばれている)およびポリスチレ
ンとポリイソプレンとのブロックコポリマー(通常はポ
リスチレン−ポリイソプレン−ポリスチレン型のトリブ
ロックコポリマーであり、SISと呼ばれる)を通常公知
の方法で酸化して(過酢酸、過安息香酸、過フタル酸な
どの過酸が使われる)、得られるものが代表例である。
また、エポキシ化前のSBSやSIS中のポリスチレン部は重
量で15〜60重量%さらに好ましくは20〜50重量
%であるのがよい。さらにSBSやSISの酸化(エポキシ
化)の度合については、エポキシ化スチレン系エラスト
マー(A)のエポキシ基含量が500〜3000グラム当
量/トンさらに好ましくは800〜2500グラム当量
/トン程度であるのが、エチレン系コポリマー(B)との
相溶性、ポリ塩化ビニル系成形品(D)およびポリオレフ
ィン系成形品(E)との親和性などのバランスから薦めら
れる。
BEST MODE FOR CARRYING OUT THE INVENTION The epoxidized styrene elastomer (A) in the present invention is a block copolymer of polystyrene and polybutadiene (usually a triblock copolymer of polystyrene-polybutadiene-polystyrene type and is called SBS. ) And a block copolymer of polystyrene and polyisoprene (usually a triblock copolymer of the polystyrene-polyisoprene-polystyrene type, referred to as SIS), which is oxidized by a known method (peracetic acid, perbenzoic acid, perphthalic acid). A peracid such as an acid is used), and the resulting one is a typical example.
The polystyrene portion in SBS or SIS before epoxidation is preferably 15 to 60% by weight, more preferably 20 to 50% by weight. Regarding the degree of oxidation (epoxidation) of SBS or SIS, the epoxy group content of the epoxidized styrene-based elastomer (A) is preferably about 500 to 3000 gram equivalent / ton, more preferably about 800 to 2500 gram equivalent / ton. It is recommended from the balance of compatibility with the ethylene copolymer (B), affinity with the polyvinyl chloride molding (D) and the polyolefin molding (E).

【0007】次に本発明におけるエチレン系コポリマー
(B)のうち、エチレン酢酸ビニルコポリマー(以下EVAと
称す)は通常公知の方法で製造されるポリマーである
が、(A)との相溶性、(D)や(E)との親和性などを考える
と酢酸ビニル含量が13〜40重量%さらに好ましくは
15〜35重量%程度のものがよい。また、成形性、成
形物の力学的性質などから、温度190℃、荷重2,1
60gにおけるメルトフローレイト(MFR)が0.2〜20
さらに好ましくは0.5〜15のものがよい。また(B)
のうちエチレンアクリル酸エステルコポリマー、エチレ
ンメタクリル酸エステルコポリマーとしては、エチレン
アクリル酸エチルコポリマー(EEA)、エチレンメタクリ
ル酸メチルコポリマー(EMMA)およびエチレンメタクリル
酸エチルコポリマー(EEMA)が代表例であり、特にEEAとE
MMAが汎用性という点で好ましい。これらのコポリマー
はEVAと同様の理由で、アクリル酸エステルもしくはメ
タクリル酸エステル含量が13〜40重量%さらに好ま
しくは15〜35重量%で、MFRが0.2〜20さらに
好ましくは0.5〜15のものがよい。重合体組成物
(C)は上記(A)と(B)とから形成されるのであるが、本発
明の目的とするポリ塩化ビニル成形品(D)およびポリオ
レフィン系成形品(E)双方への親和性(接着力)という
意味で、(A)と(B)とは重量比で好ましくは30〜80:
70〜20より好ましくは35〜70:65〜30程度
が好ましい。
Next, the ethylene copolymer of the present invention
Among (B), ethylene-vinyl acetate copolymer (hereinafter referred to as EVA) is a polymer produced by a generally known method, and has compatibility with (A), affinity with (D) and (E), and the like. In consideration of the above, it is preferable that the vinyl acetate content is about 13 to 40% by weight, more preferably about 15 to 35% by weight. In addition, from the viewpoint of moldability and mechanical properties of the molded product, the temperature is 190 ° C., the load is 2,1.
Melt flow rate (MFR) at 60 g is 0.2-20
More preferably, it is 0.5 to 15. (B)
Among ethylene acrylate copolymers and ethylene methacrylate copolymers, ethylene ethyl acrylate copolymer (EEA), ethylene methyl methacrylate copolymer (EMMA) and ethylene ethyl methacrylate copolymer (EEMA) are typical examples, and in particular EEA And E
MMA is preferred in terms of versatility. For the same reason as EVA, these copolymers have an acrylate or methacrylate content of 13 to 40% by weight, more preferably 15 to 35% by weight, and an MFR of 0.2 to 20, more preferably 0.5 to 15%. Is better. Polymer composition
(C) is formed from the above (A) and (B), but has an affinity (adhesion) to both the polyvinyl chloride molded article (D) and the polyolefin-based molded article (E) which are the objects of the present invention. (A), (A) and (B) are preferably in a weight ratio of 30 to 80:
70-20, more preferably 35-70: 65-30.

【0008】次に本発明におけるポリ塩化ビニル(以下
PVCと称す)系成形品としては数平均重合度700〜
5,000の塩化ビニル主成分ポリマーに;ジ−2−エ
チルヘキシルフタレート、ジ−n−デシルフタレート、
トリ−2−エチルヘキシルトリメリテート、ジ−2−エ
チルヘキシルアジペート、ジ−2−エチルヘキシルセバ
ケート、ブチリルトリ−n−ヘキシルシトレート、アジ
ピン酸系ポリエステル、エポキシ化大豆油などの可塑剤
を5〜70重量%配合した成形品が最も一般的である
が、その他の組成のポリ塩化ビニル組成物、また、エチ
レン酢酸ビニルコポリマー変性ポリ塩化ビニル、架橋型
ポリ塩化ビニル等からなる成形品であってもよい。
Next, the polyvinyl chloride (hereinafter referred to as "polyvinyl chloride") of the present invention
The number average degree of polymerization is 700 ~
5,000 vinyl chloride based polymers; di-2-ethylhexyl phthalate, di-n-decyl phthalate,
5 to 70% by weight of a plasticizer such as tri-2-ethylhexyl trimellitate, di-2-ethylhexyl adipate, di-2-ethylhexyl sebacate, butyryl tri-n-hexyl citrate, adipic acid-based polyester and epoxidized soybean oil % Is the most common, but it may be a polyvinyl chloride composition having another composition, or a molded article made of ethylene vinyl acetate copolymer-modified polyvinyl chloride, cross-linked polyvinyl chloride, or the like.

【0009】また、本発明におけるポリオレフィン系成
形品(E)の代表例はポリエチレン(PE)、ポリプロピレン
(PP)またはポリブテン−1(PB−1)からなる成形品であ
る。PEは、高密度ポリエチレン(HDPE)、低密度ポリエ
チレン(LDPE)および線状低密度ポリエチレン(LLDPE)い
ずれでもよいが、成形性、成形品の力学的性質などを考
慮すると、温度190℃、荷重2,160gにおけるMFR
が0.2〜30より好ましくは0.5〜20であるのが
よい。PPは、アイソタクチックタイプもしくはシンジ
オタクチックタイプの結晶性ポリプロピレンまたはこれ
らを主成分とする結晶性コポリマーであり、PEと同様の
理由で、温度230℃、荷重2,160gにおけるMFRが
0.3〜25より好ましくは0.5〜20であるのがよ
い。PB−1は、アイソタクチックポリブテン−1また
はこれを主成分とするコポリマーであり、PEと同様の理
由で、温度190℃、荷重2,160gにおけるMFRが
0.2〜30より好ましくは0.5〜25のものがよ
い。PE、PP、PB−1の他には、ポリ−4−メチル
ペンテン−1、環状ポリオレフィン等またはこれらを主
成分とするポリマーも挙げられる。
Representative examples of the polyolefin-based molded article (E) in the present invention include polyethylene (PE) and polypropylene.
(PP) or polybutene-1 (PB-1). The PE may be any of high-density polyethylene (HDPE), low-density polyethylene (LDPE) and linear low-density polyethylene (LLDPE). , MFR at 160g
Is preferably from 0.2 to 30, more preferably from 0.5 to 20. PP is a crystalline polypropylene of isotactic type or syndiotactic type or a crystalline copolymer containing these as a main component. For the same reason as PE, MFR at a temperature of 230 ° C. and a load of 2,160 g is 0.3. More preferably, it is 0.5 to 20. PB-1 is isotactic polybutene-1 or a copolymer containing the same as the main component. For the same reason as PE, MFR at a temperature of 190 ° C. and a load of 2,160 g is more preferably 0.2 to 30, and more preferably 0.2 to 30. 5-25 are preferred. In addition to PE, PP, and PB-1, poly-4-methylpentene-1, cyclic polyolefin, and the like, or a polymer containing these as a main component, may also be used.

【0010】なお、場合によっては成形品に要求される
性能に応じて他のポリマー例えばスチレン系熱可塑性エ
ラストマー、オレフィン系熱可塑性エラストマー、エチ
レン酢酸ビニルコポリマーなどを本発明の主旨を損わな
い範囲で配合してもよい。ポリ塩化ビニル成形品(D)あ
るいはポリオレフィン系成形品(E)はシート、フィル
ム、チューブ、パイプ、ジョイントなど種々の形態をな
すが、これらは通常公知の押出成形(インフレ、ブロ
ー、Tダイなど)や射出成形等で製造される。成形品(D)
および成形品(E)を得る時の成形時の溶融温度はそれぞ
れ140〜200℃および160〜240℃程度である
のがよい。
In some cases, other polymers such as a styrene-based thermoplastic elastomer, an olefin-based thermoplastic elastomer, an ethylene-vinyl acetate copolymer, etc. may be used in accordance with the performance required for the molded article within a range that does not impair the gist of the present invention. You may mix. Polyvinyl chloride molded products (D) or polyolefin-based molded products (E) take various forms such as sheets, films, tubes, pipes, joints, etc., and these are usually known by extrusion molding (inflation, blow, T-die, etc.). And manufactured by injection molding. Molded product (D)
The melting temperature at the time of molding for obtaining the molded product (E) is preferably about 140 to 200 ° C. and about 160 to 240 ° C., respectively.

【0011】[0011]

【実施例】以下実施例によって本発明をさらに具体的に
説明する。 (1)実験方法 ポリマー(A)およびポリマー(B)の準備:表1に示す。
性状はいずれもペレット状である。
The present invention will be described more specifically with reference to the following examples. (1) Experimental method Preparation of polymer (A) and polymer (B): shown in Table 1.
The properties are all pellets.

【0012】(表1) 記号 内容 (A1) ポリスチレン部とポリブタジエン部の重量比が40:60のSBSの エポキシ化物。エポキシ含量は2,100グラム当量/トン。 (A2) ポリスチレン部とポリイソプレン部の重量比が30:70のSISの エポキシ化物。エポキシ含量は1,500グラム当量/トン。 (B1) 酢酸ビニル含量25重量%、MFR2.0のEVA。 (B2) メタクリル酸メチル含量21重量%、MFR2.5のEMMA。 (C1) (A1)と(B1)との重合体組成物。重量比50:50。 (C2) (A1)と(B2)との重合体組成物。重量比65:35。(C3) (A2)と(B1)との重合体組成物。重量比50:50。 (Table 1) Symbol Description (A1) Epoxidized SBS having a weight ratio of polystyrene to polybutadiene of 40:60. Epoxy content is 2,100 gram equivalent / ton. (A2) An SIS epoxide having a weight ratio of polystyrene to polyisoprene of 30:70. The epoxy content is 1,500 gram equivalent / ton. (B1) EVA having a vinyl acetate content of 25% by weight and an MFR of 2.0. (B2) EMMA having an MFR of 2.5 and a methyl methacrylate content of 21% by weight. (C1) A polymer composition of (A1) and (B1). Weight ratio 50:50. (C2) A polymer composition of (A1) and (B2). Weight ratio 65:35. (C3) A polymer composition of (A2) and (B1). Weight ratio 50:50.

【0013】重合体組成物(C)の調製およびこれから
なるフィルムの調製:上記(A)、(B)からポリマーを適宜
選択して、150mmφのミキシングロール機で溶融混練
(温度160〜180℃)した後、180℃でプレス成
形して、厚さ50μmのフィルムとした。表1にその組
成を示す。なお、比較のため、(A)単独または(B)単独か
らなるフィルムも調製した。これらは後でポリ塩化ビニ
ル系成形品とポリオレフィン系成形品とを接着するため
に使用される接着フィルムとして用いられる。
Preparation of polymer composition (C) and preparation of a film comprising the same: A polymer is appropriately selected from the above (A) and (B) and melt-kneaded with a 150 mmφ mixing roll machine (temperature: 160 to 180 ° C.). After that, press molding was performed at 180 ° C. to obtain a film having a thickness of 50 μm. Table 1 shows the composition. For comparison, a film consisting of (A) alone or (B) alone was also prepared. These are used later as an adhesive film used for bonding a polyvinyl chloride-based molded article and a polyolefin-based molded article.

【0014】輸液用容器の製造:図1に示す本発明の
医療器具の一実施例である輸液用容器1を次のようにし
て製造した。 排出口(D1):数平均重合度1500のPVCにジ−2−エ
チルヘキシルフタレート10重量%を加えて得たコンパ
ウンドを射出成形して図2に示す全長45mm、内径8mm
の筒状のポリ塩化ビニル系成形品である輸液用容器1の
排出口2を得た。排出口2は上端に外径20mmのフラン
ジ21、それに続いて下方に外径15mmの大径部22、
さらに長さ15mm、外径12mmの小径部23を有してい
る。 輸液用容器本体(D2):数平均重合度2500のPVCにジ
−n−デシルフタレート40重量%を加えて得たコンパ
ウンドをインフレーション成形して得たシート(厚さ3
00μm、折幅150mm、長さ24cm)から図3に示す
輸液用容器本体3を作製した。すなわち、該輸液容器用
本体3は、その上端に上記排出口2の取付部31を残す
ようにして上下端をシールして製袋し、下端シール部中
央に懸架用の穴32を設けて輸液用容器本体3を得た。
Production of Infusion Container: An infusion container 1 as an embodiment of the medical device of the present invention shown in FIG. 1 was produced as follows. Discharge port (D1): A compound obtained by adding 10% by weight of di-2-ethylhexyl phthalate to PVC having a number-average degree of polymerization of 1500 is injection-molded, and the total length shown in FIG.
The discharge port 2 of the infusion container 1 which is a cylindrical polyvinyl chloride-based molded product was obtained. The outlet 2 has a flange 21 having an outer diameter of 20 mm at the upper end, followed by a large-diameter portion 22 having an outer diameter of 15 mm below,
Further, it has a small diameter portion 23 having a length of 15 mm and an outer diameter of 12 mm. Infusion container body (D2): Sheet obtained by inflation molding a compound obtained by adding 40% by weight of di-n-decyl phthalate to PVC having a number average degree of polymerization of 2500 (thickness: 3)
(00 μm, folded width 150 mm, length 24 cm), the infusion container main body 3 shown in FIG. 3 was prepared. That is, the infusion container main body 3 is sealed with the upper and lower ends so as to leave the mounting portion 31 of the discharge port 2 at the upper end, and is formed into a bag. The container main body 3 was obtained.

【0015】排出口(E1):MFR8.2のアイソタクチッ
クタイプのPPコポリマーを射出成形して上記D1と同じ
形状の図2の排出口2を得た。 輸液用容器本体(E2):密度0.922g/cm、MFR2.
4のLLDPEをインフレ成形して得たシート(厚さ300
μm、折幅150mm、長さ240mm)から上記D2と同
じ形状の図3の輸液用容器本体3を得た。 次に、で得られたフィルムを裁断した接着フィルム
(図示せず)を、図2の排出口2の小径部23全長にわ
たって一周巻き付け、輸液用容器本体3の取付部31に
この小径部の部分だけを差し込み、取付部31を金型で
挟んで温度150℃、圧力2kg/cm、時間4秒の条件
で排出口を取付けた。表2に、排出口、輸液用容器本体
および接着フィルムの組合せを示し、それぞれ実施例1
〜5および比較例1〜3とした。
Outlet (E1): An isotactic-type PP copolymer having an MFR of 8.2 was injection-molded to obtain an outlet 2 in FIG. Infusion container body (E2): density 0.922 g / cm 3 , MFR2.
4 LLDPE sheet obtained by inflation molding (thickness 300
μm, folded width 150 mm, length 240 mm), the infusion container main body 3 of FIG. 3 having the same shape as that of D2 was obtained. Next, an adhesive film (not shown) obtained by cutting the film obtained in step 1 is wound around the entire length of the small-diameter portion 23 of the discharge port 2 in FIG. And a discharge port was mounted under the conditions of a temperature of 150 ° C., a pressure of 2 kg / cm 2 , and a time of 4 seconds while sandwiching the mounting portion 31 with a mold. Table 2 shows the combinations of the outlet, the infusion container main body, and the adhesive film.
To 5 and Comparative Examples 1 to 3.

【0016】高圧蒸気滅菌処理:で得たそれぞれの
輸液用容器に生理食塩水500mlを入れ、排出口2の上
部に、輸液用ゴム栓の外周にキャップ部材を装着したキ
ャップ4をかぶせ、超音波シール法でキャップと排出口
とを融着した。なお、キャップ部材の材質は排出口と同
じものを使った。次いで、この薬液入り容器を高圧蒸気
滅菌器に入れ、温度108℃、ゲージ圧1.8kg/c
m、時間30分の条件で滅菌処理し、室温まで冷却し
た。 評価:各実施例において、の滅菌処理を5つの容器
について行い、滅菌・冷却処理後の排出口/(接着フィ
ルム)/袋の間の密着状態を内部薬液の洩れ状態を観察
した。
High-pressure steam sterilization: 500 ml of physiological saline is put into each of the infusion containers obtained in the above, and the upper part of the outlet 2 is covered with a cap 4 having a cap member attached to the outer periphery of a rubber stopper for infusion, and ultrasonically treated. The cap and the outlet were fused by a sealing method. The material of the cap member was the same as that of the discharge port. Next, the container with the drug solution was placed in a high-pressure steam sterilizer, and the temperature was 108 ° C. and the gauge pressure was 1.8 kg / c.
The solution was sterilized under the conditions of m 2 and 30 minutes, and cooled to room temperature. Evaluation: In each example, sterilization treatment was performed on five containers, and the state of close contact between the outlet / (adhesive film) / bag after sterilization / cooling treatment was observed for the leakage state of the internal chemical solution.

【0017】(表2) 例番号 排出口/接着フィルム/袋の組合せ 排出口 接着フィルム 袋 実施例 1 (D1) (C1) (E2) 2 (D1) (C2) (E2) 3 (D1) (C3) (E2) 4 (E1) (C1) (D2) 5 (E1) (C2) (D2) 比較例 1 (D1) (A1) (E2) 2 (D1) (B1) (E2) 3 (E1) (A1) (D2) (Table 2) Example No. Outlet / Adhesive Film / Bag Combination Outlet Adhesive Film Bag Example 1 (D1) (C1) (E2) 2 (D1) (C2) (E2) 3 (D1) ( (C3) (E2) 4 (E1) (C1) (D2) 5 (E1) (C2) (D2) Comparative Example 1 (D1) (A1) (E2) 2 (D1) (B1) (E2) 3 (E1 ) (A1) (D2)

【0018】(2)実験結果 実施例1〜5:滅菌前後において、排出口と接着フィル
ム、および接着フィルムと袋の間の外観変化はほとんど
なく、良好な状態で接着されていた。また、日本薬局方
(第13改正)一般試験法「プラスチック製医薬品容器
試験法」に準じ、容器について重金属および溶出物試験
を行ったところ、いずれも適合することが確認された。
(2) Experimental Results Examples 1 to 5: Before and after sterilization, there was almost no change in the appearance between the outlet and the adhesive film, and between the adhesive film and the bag, and they were adhered in a good state. In addition, heavy metals and dissolution tests were performed on the containers in accordance with the Japanese Pharmacopoeia (13th revision) general test method "Plastic drug container test method", and it was confirmed that both were compatible.

【0019】比較例1〜3:比較例1(排出口がPVC、
接着フィルムがエポキシ化SBS、袋がLLDPE)では接着フ
ィルムと袋の間、比較例2(排出口がPVC、接着フィル
ムがEVA、袋がLLDPE)では排出口と接着フィルムの間、
比較例3(排出口がPP、接着フィルムがエポキシ化SB
S、袋がPVC)では排出口と接着フィルムとの間の接着が
困難であり、高圧蒸気滅菌処理の段階に至らなかった。
Comparative Examples 1 to 3: Comparative Example 1 (the outlet was PVC,
When the adhesive film is epoxidized SBS and the bag is LLDPE), between the adhesive film and the bag, in Comparative Example 2 (the outlet is PVC, the adhesive film is EVA, and the bag is LLDPE), between the outlet and the adhesive film
Comparative Example 3 (the outlet is PP and the adhesive film is epoxidized SB
(S, bag is PVC), the adhesion between the outlet and the adhesive film was difficult, and the stage of high-pressure steam sterilization was not reached.

【0020】[0020]

【発明の効果】以上記載した如く本発明者は、エポキシ
化スチレン系エラストマーとエチレン酢酸ビニルコポリ
マー、エチレンアクリル酸エステルコポリマーもしくは
エチレンメタクリル酸エステルコポリマーとの重合体組
成物はポリ塩化ビニル系成形品およびポリオレフィン系
成形品の双方に良好な親和性を持ち、ポリ塩化ビニル系
成形品とポリオレフィン系成形品との接着にきわめて有
効であることを見いだし、ポリ塩化ビニル系成形品であ
る必要のない部分についてはその使用を減らすことに成
功した。従って、本発明は医療器具分野における材料展
開に大きく寄与するものと期待される。
As described above, the present inventor has set forth a polymer composition of an epoxidized styrene-based elastomer and an ethylene-vinyl acetate copolymer, an ethylene acrylate ester copolymer or an ethylene methacrylate ester copolymer as a polyvinyl chloride-based molded article and It has good affinity for both polyolefin-based molded products and is found to be extremely effective in bonding polyvinyl chloride-based molded products to polyolefin-based molded products. Succeeded in reducing its use. Therefore, the present invention is expected to greatly contribute to material development in the field of medical instruments.

【図面の簡単な説明】[Brief description of the drawings]

【図1】本発明の医療器具の一実施例である輸液用容器
である。
FIG. 1 is an infusion container which is an embodiment of the medical device of the present invention.

【図2】輸液用容器の排出口の断面図である。FIG. 2 is a sectional view of an outlet of an infusion container.

【図3】輸液用容器の輸液用容器本体である。FIG. 3 is an infusion container main body of the infusion container.

【符号の説明】[Explanation of symbols]

1輸液用容器、2排出口、3輸液用容器本体、4キャッ
1 infusion container, 2 outlets, 3 infusion container body, 4 caps

フロントページの続き (51)Int.Cl.6 識別記号 FI C08J 5/12 CEV C09J 123/08 C09J 119/00 131/04 123/08 133/06 131/04 A61J 1/00 331A 133/06 331B A61M 5/14 459D Continued on the front page (51) Int.Cl. 6 Identification code FI C08J 5/12 CEV C09J 123/08 C09J 119/00 131/04 123/08 133/06 131/04 A61J 1/00 331A 133/06 331B A61M 5/14 459D

Claims (4)

【特許請求の範囲】[Claims] 【請求項1】エポキシ化スチレン系エラストマーと、エ
チレン酢酸ビニルコポリマー、エチレンアクリル酸エス
テルコポリマーもしくはエチレンメタクリル酸エステル
コポリマーとの重合体組成物を介して、ポリ塩化ビニル
系成形品とポリオレフィン系成形品とが接着されている
医療器具用部材。
1. A molded article of polyvinyl chloride and a molded article of polyolefin via a polymer composition of an epoxidized styrene elastomer and an ethylene vinyl acetate copolymer, ethylene acrylate copolymer or ethylene methacrylate copolymer. A member for a medical device to which is adhered.
【請求項2】該エポキシ化スチレン系エラストマーがポ
リスチレンとポリブタジエンとのブロックコポリマーも
しくはポリスチレンとポリイソプレンとのブロックコポ
リマーのエポキシ化物である請求項1に記載の医療器具
用部材。
2. The medical device member according to claim 1, wherein the epoxidized styrene-based elastomer is an epoxidized product of a block copolymer of polystyrene and polybutadiene or a block copolymer of polystyrene and polyisoprene.
【請求項3】該ポリオレフィン系成形品がポリエチレ
ン、ポリプロピレンもしくはポリブテン−1からなる成
形品である請求項1または2に記載の医療器具用部材。
3. The medical device member according to claim 1, wherein the polyolefin-based molded product is a molded product made of polyethylene, polypropylene, or polybutene-1.
【請求項4】請求項1〜3のいずれかに記載の医療器具
用部材を構成要素とする医療器具。
4. A medical device comprising the medical device member according to claim 1.
JP9076165A 1997-03-27 1997-03-27 Member for medical instrument and medical instrument Pending JPH10263072A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9076165A JPH10263072A (en) 1997-03-27 1997-03-27 Member for medical instrument and medical instrument

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9076165A JPH10263072A (en) 1997-03-27 1997-03-27 Member for medical instrument and medical instrument

Publications (1)

Publication Number Publication Date
JPH10263072A true JPH10263072A (en) 1998-10-06

Family

ID=13597470

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9076165A Pending JPH10263072A (en) 1997-03-27 1997-03-27 Member for medical instrument and medical instrument

Country Status (1)

Country Link
JP (1) JPH10263072A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002015953A1 (en) * 2000-08-24 2002-02-28 Kuraray Co., Ltd. Process for producing medical devices
JP2006225561A (en) * 2005-02-18 2006-08-31 Jsr Corp Method for bonding thermoplastic elastomer-molded article, and compounded molded article, medical member and infusion set obtained from the same
JP2022502533A (en) * 2018-09-19 2022-01-11 ケアフュージョン 303、インコーポレイテッド Methods and formulations for combining dissimilar materials

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002015953A1 (en) * 2000-08-24 2002-02-28 Kuraray Co., Ltd. Process for producing medical devices
JP2006225561A (en) * 2005-02-18 2006-08-31 Jsr Corp Method for bonding thermoplastic elastomer-molded article, and compounded molded article, medical member and infusion set obtained from the same
JP2022502533A (en) * 2018-09-19 2022-01-11 ケアフュージョン 303、インコーポレイテッド Methods and formulations for combining dissimilar materials

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