JPH10188A - Arterial blood collecting kit - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an arterial blood collecting kit which ensures mixing of a blood with an anti-clotting agent at the time of taking blood of an artery, is free of bubble generation caused by a jetting stream of blood, and which allows the air in the blood introducing space to be exhausted completely. SOLUTION: The arterial blood collecting kit is composed of a blood collecting needle 1, an outer cylinder 2 having a needle mounting part 21, a plunger 3 inserted in the outer cylinder 2, a gasket 4 coupled with the tip of the plunger 3, a filter 5 which is installed at the joint between the head 31 of plunger 3 and a rod 32 and which transmits gas and does not transmit the blood, and an anti-clotting agent 6 which is in solid state and is accommodated in the hb 11 of the needle 1. The plunger 3 is equipped with an exhaust hole 33 in communication with the external air, while the gasket 4 is furnished with a communication hole 41 to put the space bounded by the front end face of gasket and the outer cylinder 2 in communication with the exhaust hole 33.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an arterial blood collection kit for measuring gas content, electrolyte concentration, pH, etc., contained in blood.

[0002]

2. Description of the Related Art Conventionally, arterial blood has been collected to measure the gas content in the blood for pulmonary function tests, cardiac function tests, oxygen concentration control during surgery, etc. The electrolyte concentration in the blood is measured for diagnosis of diabetes and endocrine diseases, and the pH is measured for diagnosis of alkalosis and acidosis.
If the collected blood is in contact with the air, the measured value will be affected. Therefore, it is preferable that the collected blood be cut off from the air. Therefore, conventionally, as a device for collecting arterial blood, a communication hole is provided in the center of a gasket, and a gas-permeable and blood-impermeable filter member is attached to the communication hole at least before contacting blood, thereby exhausting air. By blocking the closed end of the outer cylinder with a lump of freeze-dried blood anticoagulant, the generation of air bubbles due to the jet of blood that occurs when blood is collected from hypertensive patients, A filter that prevents swelling of the filter due to blood contact with the filter before being discharged (see Japanese Patent Publication No. 58579/1988) is known.

[0003]

The blood anticoagulant in the above-described arterial blood collection kit is fixed to the closed end portion in the outer cylinder, but may be biased toward one end of the outer cylinder during transportation. In such a case, mixing of the blood and the blood anticoagulant is not performed reliably, bubbles are generated by the jet of blood, or the blood contacts the water swellable filter before the air is completely discharged. There is a possibility that this filter may not pass air. In addition, since the freeze-drying of the blood anticoagulant is carried out through the outer cylinder of polypropylene, the efficiency of freezing and heating is low, and there is a possibility that defective molding may occur. The present invention has been made to solve the above problems, and ensures that blood and a blood anticoagulant are mixed at the time of arterial blood collection, that no air bubbles are generated by a jet of blood, and that air in the blood introduction space is completely removed It is intended to provide an arterial blood collection kit to be drained.

[0004]

That is, the present invention relates to a blood sampling needle, an outer cylinder having a blood sampling needle mounting portion, a plunger inserted into the outer cylinder, and the outer cylinder connected to a tip of the plunger. In an arterial blood collection kit including an inner wall and a gasket that slides in close contact with each other, an exhaust hole communicating with outside air is formed in the plunger, and the gasket has a space surrounded by a front end surface of the gasket and the outer cylinder. A communication hole communicating with the exhaust hole is formed, a gas-permeable and blood-impermeable filter is provided in the exhaust hole in close proximity to the communication hole, and a solid blood filter is provided in the hub of the blood collection needle. This is an arterial blood collection kit containing a coagulant. Here, the blood anticoagulant is preferably lyophilized lithium heparin.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention will be specifically described with reference to the drawings. FIG. 1 is a partial longitudinal sectional view of an arterial blood collection kit according to one embodiment of the present invention, in which a blood collection needle 1, an outer cylinder 2 having a blood collection needle mounting portion 21, and a plunger inserted into the outer cylinder 2. 3, a gasket 4 connected to the tip of the plunger 3, a gas-permeable and blood-impermeable filter 5 provided at the joint between the head 31 and the rod 32 of the plunger 3, and a hub of the blood collection needle 1. 11 is composed of a solid blood anticoagulant 6 contained in the blood anticoagulant. The plunger 3 has an exhaust hole 33 communicating with the outside air, and the gasket 4 occupies a space surrounded by the front end face and the outer cylinder 2.
And a communication hole 41 that communicates with the.

The outer cylinder 2 is generally formed of a transparent synthetic resin such as polypropylene, polystyrene, polymethylbenthene, polyethylene terephthalate, etc., and has a blood sampling needle mounting portion 21 at its tip. In addition, plunger 3
Is generally formed of polypropylene, polyethylene, or the like. Further, as the gasket 4 in the present embodiment,
The front end surface is made of butyl rubber having a smooth spherical concave surface, but it is in close contact with the outer cylinder 2 and slides inside the outer cylinder 2 to provide rubber elasticity with excellent gas barrier properties. The material is not particularly limited as long as it is a material, and synthetic rubber and natural rubber such as isoprene rubber, butadiene rubber, and styrene-butadiene rubber can be employed.

The blood collection needle mounting portion 21 in this embodiment has a shape in which the blood collection needle 1 is mounted by screwing, and this shape prevents the blood collection needle from coming off even if it receives a high arterial pressure. In addition, a locking means is provided between the outer cylinder 2 and the plunger 3 in this embodiment so that the blood collection is stopped when the maximum blood collection amount is reached. The arterial blood collection kit according to the present invention is preferably provided with a locking means in consideration of the possibility that the plunger 3 may accidentally come off.

The filter 6 in this embodiment is provided in the exhaust hole 33 of the plunger 3 in the vicinity of the communication hole 41 of the gasket 4, and includes a filter provided in the vicinity of the communication hole 41. The filter 6 of the present invention is composed of two layers, a hydrophobic filter and a nonwoven fabric. The hydrophobic filter is arranged on the outside air side, and the nonwoven fabric is surrounded by the front end face of the gasket and the outer cylinder (blood introduction space). ) Side. The hydrophobic filter prevents blood from leaking into the outside air space, and the non-woven fabric prevents blood that has reached the hydrophobic filter from flowing back to the blood introduction space side. Examples of the material of the hydrophobic filter include polytetrafluoroethylene (PTFE), polyester, cellulose, and the like.
Cotton, polyester, polypropylene and the like. With the filter 6 having such a structure and a blood collection needle cap (not shown) accommodating the sealing material, the test blood is shut off from the outside air after the blood is collected until the blood is tested.

The blood anticoagulant 6 is for preventing the collected blood from clotting, and is generally a heparin salt such as lithium heparin, potassium heparin and sodium heparin, and an EDTA such as EDTA-2NA and EDTA-2K.
Salts, citrates, fluorides, oxalates and the like can be used. As the blood anticoagulant 6 in the present invention, lithium heparin which does not affect the measured value when measuring the electrolyte concentration in blood is preferable. An excipient (glucose, lactose, simple syrup, etc.) may be mixed with the blood anticoagulant 6. The blood anticoagulant 6 does not dilute the blood,
It is dried and solidified so that it can be housed and fixed in the hub 11. Examples of the drying method include air drying, reduced pressure drying, freeze drying and the like, and freeze drying is most preferable. The blood anticoagulant 6 solidified by drying is a porous body that allows the permeation of air and blood, and the introduced blood collides with the blood to reduce the jetting force.
The amount of the blood anticoagulant 6 may be any amount from 5 units to 125 units as long as it can be fixed in the hub 11 of the blood collection needle 1. As a method for loading the blood anticoagulant 6, a method in which a solution of the blood anticoagulant is generally filled in the hub 11 of the blood collection needle 1 and dried is adopted. Alternatively, the blood anticoagulant 6 may be loaded into the hub 11 of the blood collection needle 1. By employing a method of loading the solid blood anticoagulant 6 into the hub 11 of the blood collection needle 1, an arterial blood collection kit can be easily manufactured, and defective molding is less likely to occur.

[0010]

The blood anticoagulant in the arterial blood collection kit of the present invention is accommodated in the hub of the blood collection needle, so that it can reduce the force of the blood jetting against the blood flow. Therefore, according to the present invention, mixing of blood and blood anticoagulant at the time of collecting arterial blood is ensured, no air bubbles are generated by the jet of blood, and the air in the blood introduction space is completely exhausted.

[Brief description of the drawings]

FIG. 1 is a partial longitudinal sectional view of an arterial blood collection kit of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Blood-collecting needle 11 Hub 2 Outer cylinder 21 Blood-collecting needle mounting part 3 Plunger 31 Head 32 Rod 33 Exhaust hole 4 Gasket 41 Communication hole 5 Filter 6 Blood anticoagulant

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[Procedure amendment]

[Submission date] June 24, 1996

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0004

[Correction method] Change

[Correction contents]

[0004]

That is, the present invention relates to a blood sampling needle, an outer cylinder having a blood sampling needle mounting portion, a plunger inserted into the outer cylinder, and the outer cylinder connected to a tip of the plunger. In an arterial blood collection kit including an inner wall and a gasket that slides in close contact with each other, an exhaust hole communicating with outside air is formed in the plunger, and the gasket has a space surrounded by a front end surface of the gasket and the outer cylinder. A communication hole communicating with the exhaust hole is formed, a gas-permeable and blood-impermeable filter is provided in the exhaust hole in close proximity to the communication hole, and a solid blood filter is provided in the hub of the blood collection needle. This is an arterial blood collection kit containing a coagulant. Here, the blood anticoagulant is preferably lyophilized lithium heparin. The filter is a hydrophobic filter
And two layers of non-woven fabric,
Preferably the filter is located on the outside air side
No.

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0008

[Correction method] Change

[Correction contents]

The filter 5 in this embodiment is provided in the exhaust hole 33 of the plunger 3 in the vicinity of the communication hole 41 of the gasket 4, and includes a filter provided adjacent to the communication hole 41. The filter 5 of the present invention comprises two layers, a hydrophobic filter and a nonwoven fabric. The space in which the hydrophobic filter is disposed on the outside air side and the nonwoven fabric is surrounded by the front end surface of the gasket and the outer cylinder (blood introduction space) ) Side. The hydrophobic filter prevents blood from leaking into the outside air space, and the non-woven fabric prevents blood that has reached the hydrophobic filter from flowing back to the blood introduction space side. Examples of the material of the hydrophobic filter include polytetrafluoroethylene (PTFE), polyester, cellulose, and the like.
Cotton, polyester, polypropylene and the like. With the filter 5 having such a structure and a blood collection needle cap (not shown) accommodating the sealing material, the test blood is shut off from the outside air after the blood is collected until the blood is tested.

Claims (3)

[Claims] 1. A blood sampling needle, an outer cylinder having a blood sampling needle mounting portion, a plunger inserted into the outer cylinder, and a gasket connected to a tip of the plunger and sliding closely to an inner wall of the outer cylinder. In the arterial blood collection kit, the plunger has an exhaust hole communicating with the outside air, and the gasket has a communication hole communicating a space surrounded by the front end face of the gasket and the outer cylinder with the exhaust hole. A gas permeable and blood impermeable filter is provided in the exhaust hole near the communication hole, and a solid blood anticoagulant is contained in the hub of the blood collection needle. kit. 2. The arterial blood collection kit according to claim 1, wherein the blood anticoagulant is lyophilized lithium heparin. 3. The arterial blood collection kit according to claim 1, wherein the filter comprises two layers of a hydrophobic filter and a non-woven fabric, wherein the hydrophobic filter is arranged on the outside air side.