JPS6149975B2 - - Google Patents

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood sampler with an air removal and isolation mechanism. More particularly, the present invention relates to a blood sampler provided with an air removal and shutoff mechanism, particularly for use in blood tests called blood gas analysis. Prior Art In order to know the lung function and acid-base balance state of the human body, we measure the content of oxygen and carbon dioxide in arterial blood, measure the oxygen saturation level and PH of arterial blood, and measure HCO ₃ in blood. ^- and a blood test called blood gas analysis that quantitatively analyzes electrolyte components such as Na ⁺ , K ⁺ , and Cl ^- . In such blood gas analysis, if air is mixed into the blood sample to be tested, it will seriously affect the measurement results, and it is necessary to prevent air from remaining after blood collection. For this reason, when collecting blood, use a collection container syringe that absorbs heparin solution as a blood anticoagulant, or use a collection container pre-filled with heparin solution (Japanese Utility Model Publication No. 53-49268,
52-42064, etc.), and the dead space in the collection container and blood collection needle is filled with a heparin solution to collect blood. In this case, the heparin solution used has a concentration of approximately 1000 units/ml, and water, physiological saline, etc. are used as the diluting solvent. However, this heparin solution mixes with the collected blood and dilutes the blood, and blood gas analysis results vary due to variations in the degree of blood dilution of the heparin solution.
This will interfere with accurate blood gas measurements. For this reason, heparin as an anticoagulant is added in a dry state into the collection container syringe to eliminate the adverse effects of blood dilution caused by heparin solution, and the blood collection device itself requires a separate device to remove the air in the collection container. It is required to provide a mechanism for shutting off the collected blood and air, and one example of this is proposed in US Pat. No. 4,206,768. In the blood sampling device proposed in the same specification, an operating body that slides within the sampling container and closes the opening at the rear end of the container is formed of a plunger and a gasket.
A plastic thread is attached to this operating body, and the plastic thread is sandwiched between the inner wall of the collection container and the outer wall of the gasket, and a gap communicating with the outside is formed in a part of the rear end of the inside of the collection container. It is formed. Therefore, during blood collection, the air present inside the blood collection needle and in the collection container is pushed up by the collected blood, and this air is discharged to the outside of the collection container through the gap. After all the air has been expelled and the blood collection has been completed, remove the blood collection needle from the blood vessel.
When the tip of the blood collection needle is sealed with a rubber member, etc., the plunger is rotated, and the plastic thread is wound around the plunger, the gasket and the inner wall of the collection container are in close contact, the rear end of the container is closed and sealed, and the collected blood is isolated from the outside air. be done. However, such blood sampling devices have the following drawbacks. That is, if the timing of removing the blood collection needle from the blood vessel is delayed, blood will leak out of the collection container through the plastic thread. Moreover, when pulling out the blood sampling needle from the blood vessel, one hand must be held against the patient's puncture site, and one hand must be used to pull out the blood sampling device and rotate the plunger, which requires intense training in blood sampling techniques. It takes. Furthermore, setting the plastic thread between the gasket and the collection container requires manual work, which is time-consuming and difficult to mass produce. Purpose of the Invention The present invention was created in view of the above-mentioned circumstances, and provides a blood sampling device with an air removal and shutoff mechanism that can prevent air pre-existing in a sampling container, blood sampling needle, etc. from being mixed into the collected blood. Its main purpose is to provide. A second object of the present invention is to provide a blood sampler with an air removal and shutoff mechanism that does not require filling with heparin solution, does not have the adverse effects of blood dilution caused by heparin solution, and in particular allows accurate blood gas analysis. It is about providing. The third object of the present invention is to
To provide a blood sampling device with an air removal and blocking mechanism that automatically removes air pre-existing in a sampling container, a blood sampling needle, etc., and blocks it from the outside air after removing the air, and facilitates blood sampling procedures. There is a particular thing. Other objects of the invention will become apparent from the description below. The present inventor has conducted intensive studies to achieve this purpose, and as a result, has arrived at the present invention. That is, the present invention provides a blood collection device comprising a collection container made of a tubular body, and a closing body for closing a rear end opening of the tubular body in the tubular body, and in which blood can be introduced from the tip of the tubular body. Blood collection with an air removal and shutoff mechanism, wherein a filter member containing a water-swellable polymeric material is provided in at least the collection blood contacting part of the closure body so that the inside of the collection container communicates with the outside through the filter member. It is a vessel. Specific Configuration of the Invention Hereinafter, the specific configuration of the present invention will be described in detail with reference to the drawings. In the present invention, a blood collector equipped with an air removal and shutoff mechanism has a collection container 1 consisting of a tube body. As shown in FIGS. 1 to 3, the collection container 1 consists of a transparent tube made of various synthetic resins, glass, etc., with its front and rear ends open. Then, a closure body is inserted into this collection container 1. This closing body is inserted into the tube body and closes the rear end opening of the tube body, and the closing body is configured in the following two aspects. The first aspect is a case where the closing body is configured as an operating body 2 that closes the rear opening of the tube and can closely slide inside the tube along its inner circumferential wall.
In this case, the amount of blood collected can be made variable. As described later, such an operating body 2 includes:
As long as a filter member, which will be described in detail later, can be provided so that the inside of the collection container, which is composed of the tip surface of the operating body 2 and the inner peripheral wall of the tube of the collection container 1, communicates with the outside on the operating body side. The structure and shape of the operating body 2 may be any known structure. However, rather than having the operating body 2 consist only of a plunger and sliding it inside the tube, the collection container 1 is usually placed in close contact with the inner circumferential wall of the tube, as shown in FIGS. A gasket 4 formed of a columnar elastic body capable of sliding along a peripheral wall and a plunger 3 may be connected by, for example, fitting the plunger into the rear part of the gasket 4, or as shown in FIG. For example, by attaching elastic ring-shaped bodies 4', 4' (preferably two O-rings) to the plunger 3 and connecting the two, the elastic ring-shaped bodies 4', 4' can form one collection container. It is preferable to use a device that is in close contact with the inner circumferential wall of the body and that can be slid along the inner circumferential wall. Further, as a second embodiment, the closure body can be constructed by inserting and fixing a sealing plug 2' in a predetermined position within the tubular body of the collection container 1, as shown in FIG.
In this case, the sealing plug 2' is fixed at a position where a predetermined amount of blood can be collected, and can be made of various materials, but is usually made of an elastic body. On the other hand, blood can be introduced into the tube of the collection container 1 from its tip. For this reason, the tip of the tube body is usually shaped so that the blood collection needle 7 or cardiac catheter can be attached thereto. Prior to blood collection, the hub 75 of the blood collection needle 7 is attached to the distal end of this tubular body, or the rear end of the cardiac catheter is attached, for example, via a stopcock. To configure in this way, for example, in the pipe body,
A Luer arch-shaped tip 16 having a so-called Luer taper as shown in FIG. 3 is formed,
Prior to blood collection, the hub 75 of the blood collection needle 7 is attached to the tip 16.
Alternatively, the rear end of the catheter may be fitted. In addition, as shown in FIG. 1, the tube tip 15 is shaped into a shape called a round lock (registered trademark of Terumo Co., Ltd.) lure arch, etc., and an outer peripheral portion is provided on the outside of the lure portion to form a blood sampling needle 7. The hub 75 or the rear end of the catheter may be structured such that the outer wall of the catheter is screwed onto the outer periphery and the inner wall of the catheter is fitted into the luer portion.
In such a case, please make sure to remove the tip part 1 before use.
5 and 16 are elastic plugs 19 as shown in FIG.
Preferably, the sterile condition is maintained by In addition, as shown in FIG.
The blood collection needle 7 is fitted and attached in advance through a hub 75 through a loop arch formed at the tip 16 of the tube body or a loop arch called the above-mentioned Round Lock (registered trademark) loop tip or the like. Good too. Alternatively, as shown in FIG. 2, the blood collection needle 7' is separately attached to the holder 5 by screwing, for example, via a hub 77, and the blood collection needle 7' is attached to the holder 5 by attaching the tube body of the collection container 1 to the holder 5. It is also possible to pierce the tip of one tube of a collection container in a sealed state. In this case, in the example shown in FIG. 2, an elastic stopper 6, for example a rubber stopper, through which the rear end needle tip of the blood collection needle 7' can be inserted, is inserted into the tip of the tube body of the collection container 1, and a sealing member is inserted. 65 and is sealed tightly. By fitting the collection container 1 tube into the holder 5, the blood collection needle 7' is inserted into the collection container 1 tube. After blood collection is completed, when the collection container 1 is removed from the holder 5, the piercing hole of the elastic stopper 6 is completely closed due to its own elasticity. Note that when adopting the configuration shown in FIG. 2, a Luer adapter for cardiac catheter having a piercing needle at the rear end is attached to the holder 5 instead of the blood sampling needle 7'.
The extractor may be constructed by screwing it on. Under such a premise, in the present invention, a filter member is provided at least in the collected blood contacting part of the closure body so that the inside of the collection container communicates with the outside thereof, and this filter member is coated with a water-swellable polymeric material. is contained in a dry state to provide a mechanism for removing and blocking air from the collected blood. That is, in the air removal and shutoff mechanism of the present invention, the filter member containing the water-swellable polymeric material provided at least in the blood contacting part of the closing body, that is, the operating body 2 or the sealing stopper 2', is used to remove the filter member before blood collection. Before contact with blood, part or all of the rear end of the tube of the collection container 1 is configured to be open and conductive to the outside. In order to provide a filter member at the rear end of the collection container 1 so that part or all of the operating body 2 or the sealing cap 2' is electrically connected to the outside, various methods may be used depending on the structure of the operating body 2 or the sealing cap 2'. There is. First, a case will be described in which the closure body is configured as the aforementioned operating body 2 and the amount of blood to be collected can be made variable. As a typical example of such a case, as mentioned above, an elastic ring-shaped body 4' such as an O-ring (preferably 2
When constructing the operating body 2 by attaching the plunger 3, at least the tip of the plunger 3, which faces the inside and outside of the collection container 1, may be formed of a filter member, or as shown in FIG. As shown, a communication hole is provided at the tip of the plunger 3 to communicate the inside and outside of the collection container, and a filter member 9 may be fitted into the communication hole. In another representative example in which the operating body 2 is configured by connecting a plunger 3 and a columnar gasket 4,
This columnar gasket 4 is provided with a communication hole in its axial direction, and the plunger is configured to be fitted onto the gasket so that its tip faces the gasket communication hole. At least the tip portion may be constructed of a filter member, or a filter member may be attached to the tip portion of the plunger. However, the structure is simpler than these,
Preferably, a filter member is inserted within the gasket. In this case, a communication hole is provided in the columnar gasket 4 constituting the operating body 2 in its axial direction, and a filter member 9 is inserted into the communication hole so as to close the communication hole. Examples of such a configuration are shown in FIGS. 5 to 7. In the example shown in FIG. 5, the gasket 4 has a cylindrical shape, and on the outer periphery of its tip and rear ends,
Two protrusions 411 and 413 are integrally provided so as to have an outer diameter slightly larger than the inner diameter of the tube body of the collection container 1, and maintain airtightness between the gasket 4 and the inner peripheral surface of the container 1. This reduces the interfacial resistance with the container wall and allows the gasket to slide. On the other hand, a through hole is bored in the axial direction of the central portion of the gasket 4 to form a communication hole 43. and,
A filter member 9 mounting part 45 of a predetermined shape is formed in the front part of the communication hole 43, into which the columnar filter member 9 is fitted and inserted. A plunger fitting portion 47 is formed to fit the plunger 3, and the plunger 3 is removably fitted and connected thereto. In this case, when connecting the plunger 3,
The communication hole 43 of the gasket 4 must be open to the outside. Various structures are possible to achieve this, but usually the plunger fitting surface of the gasket 4, that is, the plunger fitting part 47
When fitting the plunger, a communicating hole 4 is formed on the inner wall surface of the
In order to communicate the plunger 3 with the outside of the collection container 1, it is preferable to provide a predetermined protrusion or recess, or to provide a predetermined protrusion or recess on the gasket fitting surface of the tip of the plunger 3. An example of the latter case is shown in FIGS. 8a and 8b.
In FIGS. 8a and 8b, the tip 35 of the plunger 3 has a shape that can fit into the rear part of the gasket 4, and a recess 355 is provided on its surface. In the example shown in FIGS. 8a and 8b, the tip portion of the plunger 3 has a substantially conical tip portion 3.
5, a neck 33 connected to the gasket, and a flange 37 connected to it. It is preferable that the neck portion 33 be made long to a certain extent so that there is a certain amount of clearance. In addition, the flange part 37 is provided with FIG. 8a,
One or more incisions 375 as shown in b.
It is preferable to provide In addition, in the above, the plunger 3 is replaced by the gasket 4.
Although an example has been described in which the connector is fitted to the rear of the connector, in some cases, the two can be connected by screwing or the like. On the other hand, another example of the gasket 4 is shown in FIG. In FIG. 6, the difference from the example shown in FIG. 5 is that the front part of the gasket 4 is a flat surface, the filter member 9 is in the shape of a rotating body with a T-shaped cross section, and the rear part of the filter member is a filter member mounting part. 45, and the filter member covers almost the entire front surface of the gasket. As a result, when blood is collected, the air inside the collector that is removed by the collected blood does not come into contact with the filter member, reducing the risk that the air will remain in the container. In FIG. 7, yet another example of the gasket 4 is shown. In this case, the front part of the gasket 4 is formed to be substantially planar, and a recess 49 is provided in the center of the front part, and this recess 49 communicates with the communication hole 43, and the recess is The filter member 9 is inserted into the filter member mounting portion 45 in the communication hole 43 so as to be located in the recess. Thereby, even when blood is collected by tilting the collection container, air is collected in the recess 49, eliminating the risk of air remaining in the container. Furthermore, different from the above, the entire gasket 4 can also be formed from a filter member containing a water-swellable polymeric material. Also in this case, an extremely simple structure is realized. In such a case, the shape of the gasket 4 is the same as that described above except that the communication hole 43 as described above is not provided since the filter member 9 is not inserted separately. Therefore, as shown in FIG. 9, the gasket 4 made of the filter member 9 containing a water-swellable polymeric material usually has two protrusions 411,
413, and the rear thereof has a structure to which a plunger can be attached, for example, a plunger fitting part 47.
is formed. As shown in the figure, the front part is formed almost flat, and a recess 4 is formed in the center of the front part.
9, the risk of air remaining in the container is reduced even when blood is collected by tilting the collection container. Further, as described above, for the plunger 3 connected to such a gasket 4, a more preferable result can be obtained by lengthening the neck portion 33 or providing a notch 375 in the flange portion 37 connected to the neck portion 33. In addition, when the operating body 2 is formed from the plunger 3 and the elastic ring-shaped body 4', the elastic ring-shaped body 4' can also be formed from the filter member 9 containing a water-swellable polymeric material. On the other hand, as mentioned above, the closure body is
It is also possible to fix the sealing plug 2' at a predetermined position within the tube so that a predetermined amount of blood can be collected. In such a case, as shown in FIG. 3, the sealing plug 2' may be fixedly inserted by being locked to the rear end of the tube of the collection container 1, or it may be fixedly inserted into the tube at a predetermined position within the tube, for example, by a locking mechanism. or fixedly inserted. In this case, the closure 2' can also be formed from a filter element containing a water-swellable polymeric material. Moreover, as shown in FIG. 3, the sealing plug 2' is
It is also possible to provide a communication hole in the axial direction and insert the filter member 9 into the communication hole. Then, in accordance with the case where the filter member 9 is inserted into the gasket 4, the filter member 9 may be formed into a rotating body shape with a T-shaped cross section, or alternatively, as shown in FIG. A more preferable result can be obtained by providing a recess so that the communication holes communicate with each other and providing the filter member 9 in the recessedmost part of the recess. The filter member 9 arranged as detailed above may be made of various materials. However, in terms of ease of molding, it is preferable to use a sintered filter made of a thermoplastic polymer such as polypropylene, polyethylene, or polyacrylonitrile. Further, the filter member 9 may have a communicating hole and allow air to pass therethrough. Generally, the porosity is preferably 15 to 60%, preferably 20 to 40%, when the water-swellable polymeric material is contained in a dry state. Further, the average pore size is preferably about 1 to 20 microns, more preferably about 5 to 10 microns. Furthermore, regarding the size of the filter member 9,
Although there is no particular restriction, the length may be approximately 2 to 10 mm. Moreover, the diameter of the filter member 9,
The ratio to the inner diameter of the tube may be approximately 0.1 to 1.0. In this case, this ratio is 1.0 when the entire gasket 4 or sealing plug 2' is formed from a filter member. On the other hand, the degree of swelling of the water-swellable polymeric material contained in the filter member 9 is such that it absorbs 100% of its own weight within 10 minutes when it comes into contact with water at room temperature to body temperature.
It is preferable that the material swells up to 1000 times. As such water-swellable molecular materials, various materials known as super absorbent resins can be used. However, from the viewpoint of not having an adverse effect on the collected blood, preferred specific examples of materials include starch-acrylonitrile, starch-acrylic acid, starch-acrylamide, starch-sodium acrylate, and other hydrolysates. Examples include acrylate-based starch grafted products; for example, partially saponified polyvinyl alcohol; polyacrylate-based and acrylic acid-vinyl alcohol-based polymers; furthermore, polyethylene oxide; cellulose-based polymers, and the like. Such a water-swellable polymeric material is contained in the filter member in a dry state, usually in the form of granules. In this case, the content of the water-swellable polymeric material in the filter member is preferably 10 to 60% by weight, more preferably 20 to 40% by weight. In order to contain the water-swellable polymeric material, usually,
The filter may be formed by mixing it with a sintered filter constituent material. For example, before molding, a water-swellable polymeric material may be uniformly dispersed and mixed in a thermoplastic resin, and this may be placed in a mold and subjected to heating, pressure, etc., and molded. When the water-swellable polymeric material contained in such a filter member 9 is in a dry state, air can pass through the continuous pores, and the filter member 9 has air permeability. Further, when the water-swellable polymeric material contained therein is in a swollen state, the communicating pores are completely blocked by the swollen water-swellable polymeric material, resulting in airtightness. The blood collector with an air removal and shutoff mechanism of the present invention is constructed as described above, but it is preferable that the anti-blood coagulant 8 is contained in the collection container 1 in a dry state. As the anti-blood coagulant, it is preferable to use heparin, and the amount of heparin in the organ is usually about 0.05 to 0.1% by weight based on the amount of blood collected. In this case, in order to incorporate heparin, it is sufficient to coat the inner wall of the collection container 1 with heparin 8 in a dry state, as shown in FIGS. 1 and 3. Alternatively, as shown in FIG. 2, heparin 8 can be coated on the surface of stirring bar 9 made of a spherical material such as stainless steel. The coat may be formed by coating and drying a heparin solution, especially an aqueous solution, but it is particularly preferable to freeze the coating after coating and perform freeze-drying by sublimating water. Note that the stirring bar 8 has the effect of further promoting contact between the blood and heparin by shaking the collector after blood collection. Specific Effects of the Invention In order to collect blood using the blood collector with an air removal and shutoff mechanism of the present invention, it is generally possible to collect blood as follows. First, if necessary, use the blood sampling needle 7 and holder 5 in advance.
etc., etc. Then, as a closed body,
When using the operating tool 2, the operating tool 2 is set at a predetermined position in the collection container 1 so that a predetermined amount of blood is collected. A blood collection needle is then punctured into the artery. As a result, blood passes through the blood collection needle 7 and flows into the collection container 1. As the blood flows in, the air present in the blood collection needles 7, 7' and the collection container 1 passes through the continuous pores of the filter member 9 and is discharged to the outside of the collection container 1. When the blood excludes all air and contacts the filter member 9, the water-swellable polymeric material contained in the filter member 9 swells.
The continuous pores of the filter member 9 are blocked. After this, the blood collection needle 7 is removed from the blood vessel. At this time,
No blood spills from the needle tip. Further, blood will not seep out from the filter member 9. Blood collection is then completed by sealing the needle tip with a rubber member or the like, or by pulling out the collection container 1 from the holder when using the holder 5. In addition, in accordance with the above, a Luer tip, a Luer adapter, etc. can be connected to the rear end of the cardiac catheter via a stopcock, etc., and blood can be collected from the cardiac catheter in the same manner as described above. Further, when it is desired to collect blood while avoiding contact with air as much as possible, it is also possible to puncture the artery with the blood collection needle 7 while pushing the operating body 2 to the tip of the collection container 1. At this time, air escapes from the filter to the outside of the container, and after blood comes into contact with the filter surface, the operating body 2 automatically slides under arterial pressure. The operating body is pushed up to a predetermined blood collection amount position, and after collecting the predetermined amount, the blood collection needle is pulled out. Even in this way, the continuous pores of the filter member 9 are blocked,
Blood collection is performed anaerobically. Furthermore, when the sealing plug 2' is used as a closure, the sealing plug 2' is fixed in advance in the tube body so that a predetermined amount of blood can be collected. When the filter member 9 is connected to the filter member 9, blood flows in, air is discharged, and the continuous pores of the filter member 9 are automatically blocked, as described above. Specific Effects of the Invention According to the present invention, even when heparin is ingested in a dry state, it is possible to prevent air pre-existing in the collection container or blood collection needle from being mixed into the collected blood. In this case, for example, by simply setting the operating body 2 at a predetermined position, the air in the container will be removed and the collected blood will be shut off from the outside air reliably and automatically. Therefore, the blood sampling procedure becomes easy. As a result,
The harmful effects of heparin solution due to blood dilution are prevented,
Accurate gas analysis can be performed. In this case, in the present invention, it is only necessary to provide a filter member containing a water-swellable polymer material in the collected blood contacting part of the closure body so that the inside of the container 1 communicates with the outside thereof. Such an effect can be effectively achieved by making a few changes to the type of blood sampling device. In addition, various modes are possible for providing the filter member, and a preferable mode can be selected as appropriate depending on the structure of the extractor. Alternatively, if the gasket 4 or the sealing plug 2' is constructed from a filter member, the structure will be extremely simple and manufacturing will be easy. Furthermore, in such a case, if a recess is formed in the front surface of the gasket, the risk of air remaining even if the blood sample is collected by tilting the blood sampler can be eliminated. In addition,
If the filter member is configured as a sintered filter, its manufacture becomes extremely easy. The inventor conducted various experiments to confirm the effects of the present invention. An example is shown below. Example A collector as shown in FIG. 1 was manufactured and the effects of the present invention were confirmed. In this case, the gasket 4 had the structure shown in FIG. To explain in more detail, the filter member 9
is a sintered filter made of polyethylene, with a porosity of 40% and an average pore diameter of 5 μm. Further, this sintered filter had a cylindrical shape with an outer diameter of 4 mm and a height of 3 mm. As the water-swellable polymer material, an acrylic polymer [Aqua Keep 10SH, manufactured by Seitetsu Kagaku Kogyo Co., Ltd.] is used, and by blending this with polyethylene and sintering, the above-mentioned sintering is performed in a dry state. The content was 20% by weight in the filter. The degree of swelling of this water-swellable polymer material is such that it swells to 400 times its weight in water in 10 minutes at room temperature. Such a filter member 9 was inserted into the gasket 4 as shown in FIG. Gasket 4 is made of natural rubber and has a diameter of 13.4 mm. Next, the gasket 4 was fitted to the plunger 3 shown in FIGS. 8a and 8b, thereby constructing a collector as shown in FIG. 1. In this case, collection container 1
A 5 ml plastic syringe was used, and a 22G needle was used for blood collection. Furthermore, 2 mg of heparin was applied to the inner wall of the syringe tube and dried. In addition, in this collector, when the operation body 2 is pushed to the lowest position, the space existing inside the blood collection needle, etc. is 150μ. Using such a collector, extract from the rabbit carotid artery.
Arterial blood was collected directly. In this case, gasket 4
was set in a predetermined position, and blood samples of 1 ml, 2 ml, and 3 ml were collected from two birds. Each blood draw was completed in approximately 0.5 to 1.5 minutes. After the desired amount of blood was obtained, the blood collection needle was removed from the blood vessel, and the needle tip was sealed with a rubber member. At this time, blood did not seep out from the filter member. Next, for each blood sample, the radiometer
Using the blood gas analyzer BMS-MK2 manufactured by Co., Ltd.
PH, Po ₂ and Pco ₂ were measured. The results are shown in Table 1 below. Separately, for comparison, a comparative example was constructed in the same manner as described above, except that the communication hole 43 was not formed in the gasket 4 and the filter member 9 was not inserted. However, the heparin was not in a dry state, but was filled as a heparin solution at 1000 units/ml. Push down the operating body 2, fill the dead space with 150μ of residual heparin, then collect 1ml, 2ml, and 3ml of blood for each of the two specimens, and check the pH,
Po ₂ and Pco ₂ were measured. The results are also listed in Table 1.

[Table] From the results in Table 1, it can be seen that with the conventional blood sampling device for comparison, the results of blood dilution with heparin solution, especially Po ₂ and Pco ₂ , vary depending on the amount of blood collected, whereas with the sampling device of the present invention, It can be seen that these variations are small even when the amount of blood collected is different. Note that, unlike the above, when the entire gasket 4 was constructed from the above filter member, almost the same results as above were obtained. In addition, the water-swellable polymeric material was prepared using starch-acrylonitrile grafted material [SPG manufactured by Henkel Corporation, swelling degree 1000 times/10].
When a collector similar to the above was constructed in place of polyvinyl alcohol-based polymer [GP manufactured by Nippon Gosei Kagaku Co., Ltd., swelling degree 200 times / 10 minutes], almost the same effect as above was obtained. Obtained. Furthermore, such an effect was similarly reproduced with the collectors shown in FIGS. 2 and 3.

[Brief explanation of the drawing]

FIG. 1, FIG. 2, and FIG. 3 are partially sectional front views for explaining different embodiments of the present invention. FIG. 4 is a sectional view showing an example of the closure body according to the present invention configured as an operating body. FIGS. 5, 6, and 7 are front views, partially in cross section, for illustrating an example of a gasket constituting an operating body when the closure body of the present invention is configured as an operating body. It is a diagram. FIGS. 8a and 8b are diagrams for explaining an example of a plunger constituting an operating body when the closure body of the present invention is configured as an operating body, of which FIG. 8a is partially omitted. The front view, FIG. 8b, is the left side view of FIG. 8a. FIG. 9 is a partially sectional front view showing another example of a gasket constituting an operating body when the closing body of the present invention is configured as an operating body. 1... Collection container, 2... Operating body, 2'... Sealing, 3... Plunger, 4... Gasket,
4'...Elastic ring-shaped body, 7,7'...Blood collection needle, 9
...Filter components.

Claims (1)

[Scope of Claims] 1. A blood sampling device consisting of a collection container made of a tubular body and a closing body that closes a rear end opening of the tubular body within the tubular body, and in which blood can be introduced from the tip of the tubular body, A filter member having a communicating hole in at least the sampled blood contacting part of the closure body and containing a water-swellable polymeric material, which has air permeability when the water-swellable polymeric material is dried and has a water-swellable property. A blood sampling device with an air removal and shutoff mechanism, characterized in that the swelling property of the polymer material is provided with a filter member having airtightness, and the inside of the collection container communicates with the outside of the collection container via the filter member. 2. The blood sampling device with an air removal and blocking structure according to claim 1, wherein the tube body has a distal end portion to which a blood sampling needle or the rear end of a cardiac catheter can be attached. 3. A blood sampling device with an air removal and blocking structure according to claim 1, which comprises a blood sampling needle at the tip of the tube body. 4. The tube body is configured so that it can be attached to a holder equipped with a blood collection needle, and the tip opening is sealed at the tip of the tube body, and when the tube body is attached to the holder, the rear end of the blood collection needle is A blood sampling device with an air removal and shutoff mechanism according to claim 1, which is provided with a pierceable elastic stopper. 5. Blood with an air removal and blocking mechanism according to claims 1 to 4, wherein the closing body is an operating body that closes the rear end opening of the tube and slides closely along the peripheral wall of the tube. Collector. 6. The operating body includes a plunger and an elastic ring-shaped body connected to the plunger, tightly attached to the inner circumferential wall of the collection container tube, and capable of sliding along the inner circumferential wall, or a columnar gasket having a communicating hole in the axial direction thereof. Claim 5, wherein at least the tip of the plunger is formed from a filter member containing a water-swellable polymeric material, or the filter member is attached to the tip of the plunger.
Blood sampling device with air removal and shutoff mechanism as described in Section 1. 7. The operating body consists of a plunger and a columnar gasket connected to the plunger, tightly attached to the inner circumferential wall of the collection container tube, and slidable along the inner circumferential wall, the columnar gasket having a communication hole in the axial direction. 6. A blood sampler with an air removal and shutoff mechanism according to claim 5, wherein the communication hole of the gasket is closed with a filter member containing a water-swellable polymeric material. 8. Claim 7, wherein the tip of the plunger is fitted into the rear part of the gasket, and the fitting surface of the plunger or the gasket is provided with a protrusion or a recess so that the communication hole of the gasket communicates with the outside of the collection container. Blood collector with air removal and shutoff mechanism as described in Section 2. 9. The operating body consists of a plunger, and a columnar gasket or an elastic ring-shaped body connected to the plunger and slidable along the inner peripheral wall of the collection container tube, and the gasket or the elastic ring-shaped body is
6. A blood sampler with an air removal and shutoff mechanism according to claim 5, which is formed from a filter member containing a water-swellable polymeric material. 10 The closure body consists of a closure inserted and fixed into the tube body, and the closure is formed from a filter member containing a water-swellable polymer material, or the closure is provided with a communication hole, and the closure is provided with a communication hole. A blood sampling device with an air removal and shutoff mechanism according to any one of claims 1 to 4, the inside of which is closed with a filter member containing a water-swellable polymeric material. 11 Special claims 6 and 7 in which a recess communicating with the communication hole is provided in the front part of the gasket or sealing plug.
10. A blood sampling device with an air removal and shutoff mechanism according to paragraph 8, paragraph 10. 12. Claims 1 to 12 in which the filter portion is composed of a thermoplastic polymer sintered filter
12. A blood sampling device with an air removal and shutoff mechanism according to any one of Item 11. 13. A blood sampler with a shutoff mechanism according to any one of claims 1 to 12, wherein the filter member has a porosity of 15 to 60% and an average pore diameter of 1 to 20 μ. 14. A blood sampler with an air removal and shutoff mechanism according to any one of claims 1 to 13, wherein the filter member contains 10 to 60% by weight of a water-swellable polymer material. 15. Blood with an air removal and blocking mechanism according to any one of claims 1 to 14, wherein the water-swellable polymeric material swells to 100 to 1000 times its own weight within 10 minutes with water. Collector. 16. Any one of claims 1 to 15, wherein the water-swellable polymer material is a polymer compound selected from the group consisting of starch grafted products, polyvinyl alcohol polymers, and acrylic polymers. A blood sampling device with an air removal and shutoff mechanism as described in . 17 Claims 1 to 16 in which an anti-blood coagulant is incorporated in the collection container tube in a dry state.
A blood sampling device with an air removal and shutoff mechanism according to any one of paragraphs.