JPH10165428A - Implant for medical treatment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an implant to be implanted in a living body for treatment of a disease by reinforcing immunity. SOLUTION: This implant for treatment of a disease is to be implanted inside a produced tissue to make undifferent mesenchymal cells differentiate by electric currents. Specifically, such an implant that can supply electric currents to the produced tissue with an electric density between 10mA/cm<2> -50mA /cm<2> , or an implant made of apatite is used.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an implant which is used for treating diseases by being buried in the body of an organism and replenishing immunity by its action.

[0002]

2. Description of the Related Art Leukemia is caused by an accident such as exposure to radioactivity, or a lesion such as the occurrence of cancer in hematopoietic tissue.
To treat a patient who has to remove hematopoietic tissue, find a healthy person whose blood type matches exactly and extract some of the hematopoietic tissue from this person's bone marrow and transplant it into the patient's bone marrow. Is needed. In this case, it is not easy to find a person whose blood type is exactly the same. In some cases, healing can be expected by using the tissue of another person to supplement the function lost by the disease, as in this example, but this requires accurate matching of blood types. However, there are many blood types, and the exact agreement is not always expected even in a parent-child relationship, and its implementation is often difficult.

[0003]

If the function lost by the patient can be reproduced by using the tissue of the patient's own body, it is not necessary to obtain hematopoietic tissue from another person, and the problem of blood type disappears. . It is well known that an organism is composed of cells, and each cell has a gene, and the gene contains complete information that characterizes the organism. Therefore, if this genetic information can be fully expressed, it should be possible to reproduce the patient's own healthy tissue and complement the lost function. However, in reality, each cell constituting a higher organism is usually highly differentiated. Since the genetic information held by the cells is expressed only in a highly differentiated state, once the cells of the tissue that had lost the function are lost, the complementation cannot be made. Therefore, regeneration of the lost function by fully utilizing the genetic information originally possessed by each cell of the organism can be achieved by regeneration of crab feet and lizard tails, but it can be achieved by advanced organisms such as mammals. Is said to be impossible.

In the present invention, reproduction of this lost function is
By examining the extent to which it is possible, it seeks to provide a means for using the patient's own body tissue to regenerate the functions that the patient has lost.

[0005]

SUMMARY OF THE INVENTION The present invention is an implant for disease treatment which is embedded in a living tissue and induces the differentiation of undifferentiated mesenchymal cells by electric current.

[0006] Even in higher organisms, it is known that, when a wound is treated, a large number of undifferentiated mesenchymal cells are generated during the treatment of the wound, and this is related to the treatment of the wound. The present inventor has found that it is possible to induce the expression of genetic information originally held by cells by applying a current to undifferentiated mesenchymal cells generated a lot when incising biological tissue by surgery. By utilizing this phenomenon, a therapeutic method for regenerating lost tissue and restoring function is developed, and the implant necessary for this is the present invention.

More specifically, 10 mA / cm ² or more 5
It has a structure that allows a current to flow through a living tissue at a current density of 0 mA / cm ² or less, and an effect is exhibited by flowing a current through the living tissue using the structure. Many tests have confirmed that the above-mentioned current density range is the most suitable range for inducing the expression of genetic information inherent in cells. In addition, an implant having apatite as a main component, has a structure in which blood flows in contact with the apatite implant to generate a streaming potential, and the potential causes a current to flow through the generated tissue. And embedded in living tissue for use.

[0008] An electrode made of, for example, titanium metal or platinum is embedded in biological tissue, and when an electric current is applied to the electrode, hematopoietic tissue is generated around the electrode. When this hematopoietic tissue is transplanted into the bone marrow of the organism, hematopoietic tissue having a healthy function can be regenerated.

[0009] The same effect is obtained by embedding an apatite molded body in a biological tissue so that abundant blood flow comes into contact with the apatite, a streaming potential is generated, and a hematopoietic tissue is formed around the apatite in the same manner as when an electric current is applied from the outside. Generate. When this hematopoietic tissue is transplanted into bone marrow from which the hematopoietic tissue of the organism has been lost, hematopoietic tissue having a healthy function can be regenerated.

[0010]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described based on embodiments.

Embodiment 1 In FIG. 1, reference numeral 1 denotes a button-type silver battery,
Is connected to the electrode 4 via. Reference numeral 5 denotes an electric resistance in a range from 10 MΩ to 10 kΩ. The electromotive voltage of the battery 1 is 1.55V
It is. The electrode 4 was formed by repeatedly bending a titanium metal wire having a diameter of 0.3 mm and a length of 1064 mm so as to draw a sine curve with a period of 1 mm, and then compressing the metal wire into a cylindrical mold to reduce the outer shape of the titanium metal wire block. It is molded so as to be a cylinder having a height of 7 mm and a height of 5 mm. Battery 1, lead 2,
The base of the electrode 3 and the resistor 5 are covered and protected by an electrically insulating synthetic resin 6. The electrode obtained from the titanium metal wire lump was about 0.2 to 0.4 between the metal wires.
It is a porous body in which fine gaps of about mm are distributed almost uniformly throughout the electrode. For this reason, the liquid freely flows through the gap between the electrodes.

When such an artificial immune organ is buried in the muscle tissue of a dog having a defective hematopoietic function, and after about two weeks, the hematopoietic tissue is generated around the electrode 4 regardless of the above resistance value, and the electrode is It became buried in hematopoietic tissue. When hematopoietic tissue thus obtained was transplanted into the bone marrow of this dog, normal hematopoiesis was performed, and it was confirmed that hematopoietic functions, which were not normal before transplantation, were restored to normal.

Further, an experiment was conducted in which an alternating current was applied to a living tissue by replacing the battery 1 with an alternating current generator composed of an integrated circuit in FIG. The frequency was changed from 1 Hz to 1 kHz. The result was exactly the same as the result when the above-mentioned battery was used, and a normal hematopoietic tissue was formed around the electrode.

Example 2 A rectangular body, a cylinder, a cylinder, or the like having a size of several millimeters to several centimeters is simply buried in the back muscle of a dog in a compact made of an apatite sintered body. Generated around the apatite compact. Even if the hematopoietic tissue thus obtained was transplanted into the bone marrow of this dog, the same effect as in Example 1 could be obtained.

[0015]

The implant of the present invention generates a normal hematopoietic tissue which plays a central role in immunity by being embedded in an organism as an immune organ. Use of this normal hematopoietic tissue can restore the health of the organism.

[Brief description of the drawings]

FIG. 1 is an explanatory diagram of an embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Silver battery 2, 3 Conductor wire 4 Electrode 5 Electric resistance 6 Electric insulating synthetic resin

Claims (3)

[Claims] 1. An implant for treating a disease, which is embedded in a producing tissue and induces differentiation of undifferentiated mesenchymal cells by electric current. 2. A structure capable of passing a current to a living tissue at a current density of 10 mA / cm ² or more and 50 mA / cm ² or less,
An implant for treating a disease, characterized in that an effect is produced by flowing an electric current into a producing tissue using the same. 3. An implant containing apatite as a main component, wherein blood flows in contact with the apatite implant to generate a streaming potential, and the potential causes a current to flow through a generating tissue. An implant for treating a disease, which is used by being embedded in a production tissue.