CN106139388A - Nerve electrode and preparation method thereof - Google Patents
Nerve electrode and preparation method thereof Download PDFInfo
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- CN106139388A CN106139388A CN201610598554.5A CN201610598554A CN106139388A CN 106139388 A CN106139388 A CN 106139388A CN 201610598554 A CN201610598554 A CN 201610598554A CN 106139388 A CN106139388 A CN 106139388A
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- 210000005036 nerve Anatomy 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 62
- 229910021389 graphene Inorganic materials 0.000 claims description 62
- 239000000758 substrate Substances 0.000 claims description 25
- 230000001681 protective effect Effects 0.000 claims description 21
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 14
- 229910052709 silver Inorganic materials 0.000 claims description 14
- 239000004332 silver Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 10
- 230000005611 electricity Effects 0.000 claims description 9
- 229920002635 polyurethane Polymers 0.000 claims description 7
- 239000004814 polyurethane Substances 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 6
- 238000010168 coupling process Methods 0.000 claims description 6
- 238000005859 coupling reaction Methods 0.000 claims description 6
- 238000009413 insulation Methods 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 abstract description 7
- 238000002347 injection Methods 0.000 abstract description 6
- 239000007924 injection Substances 0.000 abstract description 6
- 229910052751 metal Inorganic materials 0.000 abstract description 4
- 239000002184 metal Substances 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 abstract description 3
- 230000004936 stimulating effect Effects 0.000 abstract description 3
- 230000004083 survival effect Effects 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 15
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 15
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 229910052719 titanium Inorganic materials 0.000 description 6
- 239000010936 titanium Substances 0.000 description 6
- 230000007794 irritation Effects 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- -1 polydimethylsiloxane Polymers 0.000 description 4
- 229920006243 acrylic copolymer Polymers 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000007772 electrode material Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910021387 carbon allotrope Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 230000005986 heart dysfunction Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/056—Transvascular endocardial electrode systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0587—Epicardial electrode systems; Endocardial electrodes piercing the pericardium
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a nerve electrode with high charge injection efficiency and good biocompatibility, which comprises a current generating device, a first electrode and a second electrode, wherein the current generating device is respectively connected with the first electrode and the second electrode through conductive metal wires; the charge injection efficiency is extremely high; the nerve cell electric stimulation repairing agent is used for electrically stimulating tissues and organs such as hearts, nerves and the like, and can promote the electric stimulation repairing of nerve cells and further promote the repairing of nerve functions; the biocompatibility is good, the nerve cells are cultured on the surface, and the cell survival rate is high; has good stability in vivo.
Description
Technical field
The invention belongs to bio-medical engineering field, particularly relate to a kind of three-dimensional porous Graphene flexibility nerve electrode and
Preparation method.
Background technology
Neururgic basic function unit neuron has the function accepting to stimulate and conduct impulses is excited, and electricity irritation is treated
Method, by applying the nervous tissue that suitable waveform directly contacts with the stimulating electrical signal of frequency on nerve electrode, activates neuron
Activity, thus improve neural dysfunction.Cardiac pacemaker is to be implanted in internal electronic therapeutic instrument, passes through pulse
Generator output is provided the electric pulse of energy, by the conduction of lead electrode, the cardiac muscle that stimulating electrode is contacted by battery, makes the heart
Dirty excitement and contraction, thus reach to treat some arrhythmia caused heart dysfunction.
Conventional metals silk electrode such as platinum, gold, titanium etc., although had significant progress, but still be faced with following asking
Topic: the electrode material of (1) rigidity is big with the mechanical performance difference of soft tissue, it is difficult to realize the effective integration with soft tissue；(2) electricity
Lotus injection efficiency is poor；(3) poor biocompatibility.The clinical practice of embedded nerve electrode is had emphatically by Development of Novel electrode material
Big meaning.
Because above-mentioned defect, the design people, the most in addition research and innovation, to founding a kind of nerve electrode and system thereof
Preparation Method so that it is have more the value in industry.
Summary of the invention
For solving above-mentioned technical problem, it is an object of the invention to provide a kind of electric charge injection efficiency height, good biocompatibility
Nerve electrode.
A kind of nerve electrode of the present invention, including current generating apparatus, the first electrode and the second electrode, described electric current occurs
Device is connected with described first electrode and the second electrode by conductive wire respectively, in described first electrode and the second electrode
At least one is Graphene electrodes；Graphene electrodes is discoid or strip.
Further, described Graphene electrodes is three-dimensional porous Graphene electrodes.
Further, described conductive wire is externally provided with the protection set of insulation.
Further, described protection set material is silica gel or polyurethane, and its thickness is between 0.5-3mm
Further, described conductive wire is filamentary silver or copper wire, preferably filamentary silver.
Further, described conductive wire is connected by conducting resinl and three-dimensional porous Graphene electrodes, preferably elargol.
Further, described three-dimensional porous Graphene electrodes is provided with protective substrate.
Further, described protective substrate is made up of polymeric material, and polymeric material includes polydimethylsiloxane
(PDMS), polyurethane or acrylic copolymer, preferably PDMS.
Further, the thickness of described protective substrate is 0.1-2mm.
Further, the thickness of described three-dimensional porous Graphene electrodes and described protective substrate is than for 1:0.25-4.
The preparation method of the nerve electrode of the present invention, comprises the following steps:
(1) three-dimensional porous Graphene electrodes is bonding by conducting resinl and conductive wire, and make conducting resinl be fully cured；
(2) coupling part of conductive wire and three-dimensional porous Graphene electrodes is soaked in a polymer solution, make to gather
Compound solidifies, and prepares protective substrate；In polymer solution polymeric material include polydimethylsiloxane (PDMS), polyurethane or
Acrylic copolymer, preferably PDMS；
(3) three-dimensional porous Graphene electrodes and another electrode with protective substrate is passed through conductive wire and electricity respectively
Flow generating apparatus connects, and prepares nerve electrode.
Graphene, as another the New Type of Carbon allotrope after finding continue fullerene and CNT, has uniqueness
Atomic structure and electronic structure so that it shows the multiple outstanding performance that traditional material does not has, such as the theory of super large
Specific surface area, good electrical and thermal conductivity, excellent mechanical property, pliability and elasticity (percentage of elongation of nearly 20%), optical
The features such as energy and biocompatibility.And three-dimensional porous Graphene remains the inherent attribute that two-dimensional graphene is superior, have higher
Specific surface area and surface chemical modification ability.Thus, build nerve electrode based on three-dimensional porous grapheme foam, put electricity to good use
Stimulate, treat disease, and then improve quality of life of patients, there is the highest economic worth.
By such scheme, the present invention at least has the advantage that
The present invention provides a kind of three-dimensional porous Graphene flexibility nerve electrode and preparation method thereof, and this nerve electrode includes three
Dimension porous graphene electrode, can apply electricity irritation to the regional area of histoorgan；This nerve electrode has high-specific surface area
Three-dimensional net structure, quality is soft, and good stability is amenable to repeatedly press folding, rollable use；There is high electric charge note
Enter efficiency；For histoorgans such as electricity irritation heart, nerves, the electricity irritation reparation of neurocyte can be promoted, then promote nerve
Function is repaired；Good biocompatibility, surface cultured nerve cell, cell survival rate is high；Internal good stability.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of description, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention；
Fig. 2 is three-dimensional porous Graphene electrodes and the structural representation of protective substrate in the present invention.
Detailed description of the invention
Below in conjunction with the accompanying drawings and embodiment, the detailed description of the invention of the present invention is described in further detail.Hereinafter implement
Example is used for illustrating the present invention, but is not limited to the scope of the present invention.
See Fig. 1 and Fig. 2, a kind of nerve electrode described in a preferred embodiment of the present invention, including current generating apparatus 1,
First electrode 3 and the second electrode 31, described current generating apparatus 1 is respectively by conductive wire 2 and described first electrode 3 and the
Two electrodes 31 are connected, and in described first electrode 3 and the second electrode 31, at least one is Graphene electrodes；Graphene electrodes is circle
Plate-like or strip.
In order to increase specific surface area, improving electric charge injection rate and stability, described Graphene electrodes is three-dimensional porous graphite
Alkene electrode 4.
In order to avoid potential safety hazard, described conductive wire 2 is externally provided with the protection set 5 of insulation.
Preferably, described protection set 5 materials are silica gel or polyurethane, and its thickness is between 0.5-3mm.
Preferably, described conductive wire 2 is filamentary silver or copper wire, preferably filamentary silver.
Preferably, described conductive wire 2 is connected by conducting resinl and three-dimensional porous Graphene electrodes 4, preferably elargol.
In order to support three-dimensional porous Graphene electrodes 4, protect conductive wire 2-elargol-three-dimensional porous Graphene electrodes 4
The face that is conductively connected, described three-dimensional porous Graphene electrodes 4 is provided with protective substrate 6.
Preferably, described protective substrate 6 is made up of polymeric material, and polymeric material includes polydimethylsiloxane
(PDMS), polyurethane or acrylic copolymer, preferably PDMS.
Preferably, the thickness of described protective substrate 6 is 0.1-2mm.
Described three-dimensional porous Graphene electrodes 4 thickness is too big, causes soft not, and weight is big, and serviceability is the best；The thinnest
The most shaky, it is impossible to shielding protection substrate 6 contact tissue completely, therefore, described three-dimensional porous Graphene electrodes 4 and described protection
The thickness of substrate 6 is than for 1:0.25-4.
Embodiment 1: the preparation of nerve electrode
Comprise the following steps:
(1) by elargol by bonding to three-dimensional porous Graphene electrodes 4 and filamentary silver, and it is heated to 70 DEG C and makes elargol the most solid
Changing, three-dimensional porous Graphene electrodes 4 thickness is 0.5mm；
(2) being immersed in PDMS solution the coupling part of filamentary silver and three-dimensional porous Graphene electrodes 4, evacuation removes mixed
Closing the bubble in liquid, make PDMS solidify in 70 DEG C of insulation 6h, prepare protective substrate 6, thickness is 2mm；
(3) three-dimensional porous Graphene electrodes 4 and the Titanium electrode with protective substrate 6 is passed through filamentary silver and electric current respectively
Generating means 1 connects, and prepares nerve electrode.
Embodiment 2: the preparation of nerve electrode
Comprise the following steps:
(1) by elargol by bonding to three-dimensional porous Graphene electrodes 4 and copper wire, and it is heated to 50 DEG C and makes elargol the most solid
Changing, three-dimensional porous Graphene electrodes 4 thickness is 2mm；
(2) being immersed in PDMS solution the coupling part of copper wire and three-dimensional porous Graphene electrodes 4, evacuation removes mixed
Closing the bubble in liquid, make PDMS solidify in 100 DEG C of insulation 1h, prepare protective substrate 6, thickness is 0.5mm；Before PDMS solidifies,
One heart-shaped mould can be pressed in graphenic surface gently so that it is produce heart-shaped deformation, after PDMS is fully cured, obtain recessed
The electrode fallen into, preferably to fit with heart area；
(3) three-dimensional porous Graphene electrodes 4 and the metal foil electrodes with protective substrate 6 is passed through copper wire and electric current respectively
Generating means 1 connects, and prepares nerve electrode.
Embodiment 3: the preparation of nerve electrode
Comprise the following steps:
(1) by elargol by bonding to three-dimensional porous Graphene electrodes and filamentary silver, and it is heated to 60 DEG C and makes elargol be fully cured,
Three-dimensional porous Graphene electrodes 4 thickness is 1mm；
(2) by the coupling part rapid soaking of filamentary silver and three-dimensional porous Graphene electrodes 4 in polyurethane solutions, evacuation
Removing the bubble in mixed liquor, room temperature places 24h so that urethane cures, gained protective substrate 6 thickness about 1mm.
(3) three-dimensional porous Graphene electrodes 4 and the Aurum metallicum electrode with protective substrate 6 is passed through filamentary silver and electric current respectively
Generating means 1 connects, and prepares nerve electrode.
Embodiment 4: the preparation of nerve electrode
Comprise the following steps:
(1) by elargol, two three-dimensional porous Graphene electrodes are bonding with filamentary silver respectively, and be heated to 60 DEG C and make elargol
Being fully cured, three-dimensional porous Graphene electrodes 4 thickness is 1mm；
(2) coupling part of one of them filamentary silver and three-dimensional porous Graphene electrodes 4 is immersed in polyacrylic pre-polymerization
In liquid solution, evacuation removes the bubble in mixed liquor, irradiates 6h so that polyacrylic acid solidifies under ultraviolet light (10W), and gained is protected
Protect substrate 6 thickness about 1mm；
(3) by the three-dimensional porous Graphene electrodes 4 with protective substrate 6 with another three-dimensional porous Graphene electrodes respectively
It is connected with current generating apparatus 1 by filamentary silver, prepares nerve electrode.
The operation principle of the present invention is as follows:
Applying in cardiac pacemaker by prepared three-dimensional porous Graphene flexibility nerve electrode, three-dimensional porous Graphene is soft
One of them electrode of property nerve electrode is three-dimensional porous Graphene electrodes 4, and another electrode is Titanium electrode, and three-dimensional is many
It is interior for the electric pulse sent to heart that hole Graphene electrodes 4 implants human heart, and cardiac stimulus is beated；Wherein, Titanium electricity
Titanium in extremely is alternatively metal platinum or gold, and Titanium electrode can also be three-dimensional porous Graphene electrodes 4.
The three-dimensional porous Graphene flexibility nerve electrode prepared can also be wrapped on nerve use, and typically used as process is such as
Under: operation strips out nerve, then the three-dimensional porous Graphene electrodes 4 of strip is wound around gently on nerve, and operation is the softst
To avoid Graphene to crush, then sew up the tissue of incision.
After tested, the effect using three-dimensional porous Graphene flexibility nerve electrode is: unit are electric charge injection rate is to pass
3-100 times of system electrode；Surface cultured nerve cell, cell survival rate is higher than 90%；Graphene end face can crimp use；Warp
After 100 curlings, resistance variations is less than 50%；After implanting, in 3 months, change in resistance is less than 200%.
The above is only the preferred embodiment of the present invention, is not limited to the present invention, it is noted that for this skill
For the those of ordinary skill in art field, on the premise of without departing from the technology of the present invention principle, it is also possible to make some improvement and
Modification, these improve and modification also should be regarded as protection scope of the present invention.
Claims (10)
1. a nerve electrode, including current generating apparatus, the first electrode and the second electrode, described current generating apparatus leads to respectively
Cross conductive wire to be connected with described first electrode and the second electrode, it is characterised in that: described first electrode and the second electrode
In at least one is Graphene electrodes.
Nerve electrode the most according to claim 1, it is characterised in that: described Graphene electrodes is three-dimensional porous Graphene electricity
Pole.
Nerve electrode the most according to claim 1, it is characterised in that: described conductive wire is externally provided with the protection of insulation
Set.
Nerve electrode the most according to claim 3, it is characterised in that: described protection set material is silica gel or polyurethane.
Nerve electrode the most according to claim 1, it is characterised in that: described conductive wire is filamentary silver or copper wire.
Nerve electrode the most according to claim 2, it is characterised in that: described conductive wire is many by conducting resinl and three-dimensional
Hole Graphene electrodes connects.
7. according to the nerve electrode described in claim 2 or 6, it is characterised in that: described three-dimensional porous Graphene electrodes be provided with by
The protective substrate that polymeric material is constituted.
Nerve electrode the most according to claim 7, it is characterised in that: the thickness of described protective substrate is 0.1-2mm.
Nerve electrode the most according to claim 7, it is characterised in that: described three-dimensional porous Graphene electrodes and described protection
The thickness of substrate is than for 1:0.25-4.
10. the preparation method of the nerve electrode as described in claim 1-9 is arbitrary, it is characterised in that comprise the following steps:
(1) three-dimensional porous Graphene electrodes is bonding by conducting resinl and conductive wire；
(2) coupling part of conductive wire and three-dimensional porous Graphene electrodes is soaked in a polymer solution, make polymer
Solidification, prepares protective substrate；
(3) three-dimensional porous Graphene electrodes and another electrode with protective substrate is sent out with electric current by conductive wire respectively
Generating apparatus connects, and prepares nerve electrode.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610598554.5A CN106139388B (en) | 2016-07-28 | 2016-07-28 | Nerve electrode |
| PCT/CN2017/083737 WO2017219776A1 (en) | 2016-06-22 | 2017-05-10 | Neural electrode based on three-dimensional porous graphene material and applications of three-dimensional porous graphene material in preparation of bone defect filler |
| US16/320,141 US11145850B2 (en) | 2016-06-22 | 2017-05-10 | Soft neural electrode based on three-dimensional porous graphene foam material and use of three-dimensional porous graphene foam material to prepare bone defect filler |
| US17/378,630 US11862786B2 (en) | 2016-06-22 | 2021-07-16 | Three-dimensional porous graphene foam material to prepare bone defect filler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610598554.5A CN106139388B (en) | 2016-07-28 | 2016-07-28 | Nerve electrode |
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| Publication Number | Publication Date |
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| CN106139388A true CN106139388A (en) | 2016-11-23 |
| CN106139388B CN106139388B (en) | 2018-09-25 |
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| CN201610598554.5A Active CN106139388B (en) | 2016-06-22 | 2016-07-28 | Nerve electrode |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441619A (en) * | 2017-08-17 | 2017-12-08 | 成都三乙医疗科技有限公司 | A kind of thermal conducting piece for electrotherapy |
| WO2017219776A1 (en) * | 2016-06-22 | 2017-12-28 | 苏州大学 | Neural electrode based on three-dimensional porous graphene material and applications of three-dimensional porous graphene material in preparation of bone defect filler |
| CN108187147A (en) * | 2018-02-06 | 2018-06-22 | 广东泰宝医疗器械技术研究院有限公司 | A kind of CO2 laser weld stent and preparation method thereof |
| CN110467738A (en) * | 2019-08-02 | 2019-11-19 | 温州医科大学 | A kind of preparation method of flexible nano electrode and its promoting the application in the growth of eye trigeminal neuralgia cell |
| CN112933406A (en) * | 2021-01-22 | 2021-06-11 | 北京工业大学 | Brain micro device and manufacturing method thereof |
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| CN104078248A (en) * | 2014-06-10 | 2014-10-01 | 北京大学深圳研究生院 | Flexible electrode and preparation method thereof |
| CN206228767U (en) * | 2016-07-28 | 2017-06-09 | 苏州大学 | Nerve electrode and preparation method thereof |
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