JPH10158607A - Sheet for medical container - Google Patents
Sheet for medical containerInfo
- Publication number
- JPH10158607A JPH10158607A JP8325389A JP32538996A JPH10158607A JP H10158607 A JPH10158607 A JP H10158607A JP 8325389 A JP8325389 A JP 8325389A JP 32538996 A JP32538996 A JP 32538996A JP H10158607 A JPH10158607 A JP H10158607A
- Authority
- JP
- Japan
- Prior art keywords
- sheet
- heat
- sensitive adhesive
- copolymer resin
- vinyl chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、医療容器用シート
に関するものである。更に詳しくは、血液バック、輸液
バック等に貼着使用される感熱性接着シートに関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical container sheet. More specifically, the present invention relates to a heat-sensitive adhesive sheet to be adhered to a blood bag, an infusion bag and the like.
【０００２】[0002]
【従来の技術】従来、血液バックや輸液バック等の可と
う性容器に直接ラベルを貼る場合、感圧接着性ラベルが
用いられていた。感圧接着性ラベルは常温で粘着性を示
すため簡便に貼ることができるが、その一方で粘着力が
弱く、経時により粘着力の低下が見られるなどの欠点を
有していた。粘着力の低下は、血液バックが低温または
高温に曝された場合に剥がれ落ちたり、誤って貼り替え
られるなどの極めて重大な事故を起こしかねない。2. Description of the Related Art Conventionally, when a label is directly applied to a flexible container such as a blood bag or an infusion bag, a pressure-sensitive adhesive label has been used. The pressure-sensitive adhesive label can be easily applied because it shows adhesiveness at room temperature, but on the other hand, has a disadvantage that the adhesive strength is weak and the adhesive strength is reduced with time. Decreased adhesion can cause grave accidents such as peeling off or accidental replacement of blood bags when exposed to low or high temperatures.
【０００３】そこで感圧接着性ラベルに代わり、血液バ
ックと強固に接着し、経時による粘着力の低下もほとん
ど無い感熱性接着シートが開発されてきたが、血液バッ
クのような表面に凸凹のある医療用容器には、十分満足
するにいたるラベルは見いだされなかった。[0003] Therefore, instead of a pressure-sensitive adhesive label, a heat-sensitive adhesive sheet has been developed which firmly adheres to a blood bag and hardly loses the adhesive force with the lapse of time. No satisfactory label was found on the medical container.
【０００４】[0004]
【発明が解決しようとする課題】この問題を解決するた
めに特公平５−１８４３３号公報の構成ではメチルメタ
クリレート（ＭＭＡ）−ブチルメタクリレート（ＢＭ
Ａ）共重合体とアルキルまたはシクロアルキルのフタル
酸エステル類または脂肪酸エステル類である可塑剤を含
有することによって、血液バックから剥離する心配のな
い感熱性接着シートを提案している。しかしながらこの
構成では、シートを血液バックに貼った後、高圧蒸気滅
菌処理をするとシートと血液バックの間に気泡が入り、
シートが剥がれたり、破れたりするという課題があっ
た。In order to solve this problem, Japanese Patent Publication No. 18433/1993 discloses a configuration of methyl methacrylate (MMA) -butyl methacrylate (BM).
A) A heat-sensitive adhesive sheet is proposed which contains a copolymer and a plasticizer which is a phthalic acid ester or a fatty acid ester of an alkyl or cycloalkyl so that there is no fear of peeling from a blood bag. However, in this configuration, after applying the sheet to the blood bag and then performing high-pressure steam sterilization, air bubbles enter between the sheet and the blood bag,
There was a problem that the sheet was peeled or torn.
【０００５】[0005]
【課題を解決するための手段】本発明者等は、このよう
な課題を解決すべく鋭意研究を重ねた結果、特定の配合
からなる感熱性接着剤層を設けることにより課題を解決
できることを見いだしたのである。本発明は、紙基材の
片面に、アクリル系共重合樹脂と塩化ビニル／酢酸ビニ
ル系共重合樹脂を主成分とする感熱性接着剤を塗工した
ことを特徴とする医療容器用シートである。また、アク
リル系共重合樹脂と塩化ビニル／酢酸ビニル系共重合樹
脂から成る感熱性接着剤に５〜１５重量％の可塑剤を加
える医療容器用シートである。Means for Solving the Problems The present inventors have conducted intensive studies to solve such problems and found that the problems can be solved by providing a heat-sensitive adhesive layer having a specific composition. It was. The present invention is a sheet for a medical container, characterized in that a heat-sensitive adhesive mainly composed of an acrylic copolymer resin and a vinyl chloride / vinyl acetate copolymer resin is applied to one surface of a paper substrate. . Further, it is a sheet for a medical container in which 5 to 15% by weight of a plasticizer is added to a heat-sensitive adhesive comprising an acrylic copolymer resin and a vinyl chloride / vinyl acetate copolymer resin.
【０００６】[0006]
【発明の実施の形態】本発明の医療容器用シートは、血
液バック、輸液バック等に貼り付けるものであり、一度
貼り付けたシートは二度と剥がれることが無く、無理に
剥がそうとすると紙破れを起こすシートに関するもので
ある。BEST MODE FOR CARRYING OUT THE INVENTION The sheet for medical containers of the present invention is to be adhered to a blood bag, an infusion bag or the like, and the sheet once adhered will not be peeled off again. It is about the wake-up sheet.
【０００７】本発明の紙基材は、基材の片面が水性また
は油性のサインペン、マジックなどで筆記ができ、さら
にメーカー名、製造番号等が鮮明に印刷できればよい。
従って特に限定されるものではないが、例えば血液バッ
クは極端な低温、温水解凍等、対冷凍性、耐水性を要求
される厳しい環境に曝されることが多いため、アクリル
酸エステル、尿素−ホルムアルデヒド樹脂、メラミン−
ホルムアルデヒド樹脂、ポリアミド−ポリアミン−エピ
クロールヒドリン樹脂等の耐水性樹脂を含浸させた含浸
紙が好ましい。[0007] The paper substrate of the present invention may be such that one side of the substrate can be written with an aqueous or oily felt-tip pen, magic, or the like, and the maker name, serial number, etc. can be clearly printed.
Therefore, although not particularly limited, for example, blood bags are often exposed to severe environments requiring freezing and water resistance, such as extremely low temperature, hot water thawing, etc., so that acrylic esters, urea-formaldehyde, etc. Resin, melamine-
An impregnated paper impregnated with a water-resistant resin such as a formaldehyde resin or a polyamide-polyamine-epichlorhydrin resin is preferred.
【０００８】更にこれらの含浸紙の片面に印刷適性向上
のため、重質炭酸カルシウム、軽質炭酸カルシウム、カ
オリン、クレー、亜硫酸カルシウム、硫酸バリウム、水
酸化アルミニウム、石膏、二酸化チタン、サチンホワイ
ト、タルク、酸化亜鉛等の無機顔料やプラスチックピグ
メント、ポリスチレン微粒子、尿素ホルマリン樹脂微粒
子、微小中空微粒子等の有機顔料の塗工層を設けた含浸
塗工紙であればさらに好ましい。なお、感熱性接着剤層
を設ける面に、顔料塗工層を有する含浸両面塗工紙を用
いてもよい。Further, in order to improve the printability on one side of these impregnated papers, heavy calcium carbonate, light calcium carbonate, kaolin, clay, calcium sulfite, barium sulfate, aluminum hydroxide, gypsum, titanium dioxide, satin white, talc, An impregnated coated paper provided with a coating layer of an organic pigment such as an inorganic pigment such as zinc oxide, plastic pigment, polystyrene fine particles, urea formalin resin fine particles, and fine hollow fine particles is more preferable. Note that impregnated double-coated paper having a pigment coating layer on the surface on which the heat-sensitive adhesive layer is provided may be used.
【０００９】本発明で使用する感熱性接着剤としては、
アクリル系共重合体と塩化ビニル／酢酸ビニル系共重合
体を主成分としたものを使用する。アクリル系共重合体
としては、そのモノマー組成は血液バック等の軟質塩化
ビニル製の容器を被着体とする場合には、該軟質塩化ビ
ニル製の容器との接着性の良好なメチルメタクリレート
を主体とすることが好ましく、エチルメタクリレート、
ブチルメタクリレート、イソブチルメタクリレート、ヘ
キシルメタクリレート、２−エチルヘキシルメタクリレ
ート等との共重合せしめることにより、可とう性容器に
ある程度追従できる皮膜を得られる。メチルメタクリレ
ートと他の成分との共重合比率（モル）は特に限定され
るものではないが、メチルメタクリレートの比率（モ
ル）は５０％以上有することが望ましい。The heat-sensitive adhesive used in the present invention includes:
Use is made mainly of an acrylic copolymer and a vinyl chloride / vinyl acetate copolymer. When the acrylic copolymer is to be adhered to a container made of soft vinyl chloride such as a blood bag, the monomer composition is mainly composed of methyl methacrylate having good adhesion to the container made of soft vinyl chloride. Preferably, ethyl methacrylate,
By copolymerizing with butyl methacrylate, isobutyl methacrylate, hexyl methacrylate, 2-ethylhexyl methacrylate, etc., it is possible to obtain a film which can follow a flexible container to some extent. The copolymerization ratio (mol) of methyl methacrylate and other components is not particularly limited, but the methyl methacrylate ratio (mol) is desirably 50% or more.
【００１０】さらに、上記アクリル系共重合体に塩化ビ
ニル／酢酸ビニル系共重合体を比率（モル）９０：１０
〜５０：５０でブレンドすることにより熱可塑流動性が
増加し、適性加工温度範囲が広がり、従って低温加工が
容易になるため血液バック等にシートを貼り付ける際に
非常に効果的である。また、紙基材に対する接着性も良
好である。アクリル系共重合体が９０％を越えると皮膜
が硬く、可とう性容器に十分追従できない。また５０％
未満であると被着体に対する接着が不十分となる。Further, a vinyl chloride / vinyl acetate copolymer is added to the acrylic copolymer at a ratio (mol) of 90:10.
Blending at ~ 50: 50 increases the thermoplastic fluidity, broadens the suitable processing temperature range, and thus facilitates low-temperature processing, which is very effective when attaching a sheet to a blood bag or the like. Further, the adhesiveness to the paper substrate is also good. If the content of the acrylic copolymer exceeds 90%, the film is hard and cannot sufficiently follow a flexible container. Also 50%
If it is less than 3, adhesion to the adherend becomes insufficient.
【００１１】本発明において、感熱性接着剤に更に可塑
剤を加えることが好ましい。可塑剤としては、オキシ酸
エステル系、二価アルコールエステル系、リン酸エステ
ル系、フタル酸エステル系、脂肪族一塩基酸エステル
系、脂肪族二塩基酸エステル系などから選ばれる少なく
とも１種のものが用いらる。上記重合体に５〜１５重量
％ブレンドすることにより、血液バック等の可とう性容
器との接着温度を低下させることができ、また軟質塩化
ビニル系の容器に多量に含まれる可塑剤の移行を抑える
役割を果たす。因みに５％未満では可とう性容器に含ま
れる可塑剤の移行が起こりやすくなり、１５％を越える
と接着力が若干劣る傾向になる。In the present invention, it is preferable to further add a plasticizer to the heat-sensitive adhesive. The plasticizer is at least one selected from oxyacid esters, dihydric alcohol esters, phosphate esters, phthalate esters, aliphatic monobasic acid esters, aliphatic dibasic acid esters, and the like. Is used. By blending the polymer with 5 to 15% by weight, the adhesive temperature with a flexible container such as a blood bag can be reduced, and the transfer of a large amount of a plasticizer contained in a soft vinyl chloride container can be prevented. It plays a role in suppressing. By the way, if it is less than 5%, the migration of the plasticizer contained in the flexible container tends to occur, and if it exceeds 15%, the adhesive strength tends to be slightly inferior.
【００１２】本発明の医療容器用シートを被着体に貼り
付ける場合、被着体の材質によっても差はあるが、通常
７５〜１１５℃の温度で、０．５〜５．５ｋｇ／ｃｍ2
の圧力をかけ、１〜４秒間圧接する。この条件によりシ
ートと被着体が強固に接着される。When the sheet for a medical container of the present invention is adhered to an adherend, there is a difference depending on the material of the adherend, but usually at a temperature of 75 to 115 ° C. and 0.5 to 5.5 kg / cm 2.
And press in for 1-4 seconds. Under these conditions, the sheet and the adherend are firmly bonded.
【００１３】また、このシートが血液バックなどに用い
られる場合、高圧蒸気滅菌処理が行われるが、本発明の
構成によりシートと血液バックが強固に接着されている
ため、この工程によって血液バック中に浸透した水分の
蒸散による血液バックとシート間の気泡の発生は起こら
ない。When this sheet is used for a blood bag or the like, high-pressure steam sterilization is performed. However, since the sheet and the blood bag are firmly adhered by the structure of the present invention, this step causes No air bubbles are generated between the blood bag and the sheet due to evaporation of the permeated water.
【００１４】[0014]
【実施例】以下、実施例により本発明を具体的に説明す
るが、もちろん本発明はこれによって限定されるもので
はない。EXAMPLES The present invention will be described below in more detail with reference to Examples, but it should be understood that the present invention is by no means restricted thereto.
【００１５】実施例１ 〔感熱性接着剤の製造〕メチルメタクリレート６０モル
％、イソブチルメタクリレート４０モル％を十分に窒素
置換したセパラブルフラスコに仕込み、重合開始剤のア
ゾビスイソブチロニトリル（ＡＩＢＮ）０．１重量部を
攪拌しながら徐々に加え、窒素置換しながら６０℃、２
時間加熱して反応終了とする。これとは別に準備した塩
化ビニル／酢酸ビニル共重合体を２５モル％ブレンド
し、得られた重合物にオキシ酸エステルを１２重量％加
え、感熱性接着剤を得た。Example 1 [Production of heat-sensitive adhesive] A separable flask in which 60 mol% of methyl methacrylate and 40 mol% of isobutyl methacrylate were sufficiently substituted with nitrogen was charged, and azobisisobutyronitrile (AIBN) as a polymerization initiator was charged. 0.1 parts by weight were gradually added with stirring, and at 60 ° C.,
Heat for a period of time to complete the reaction. Separately, 25 mol% of a vinyl chloride / vinyl acetate copolymer prepared was blended, and 12% by weight of an oxyacid ester was added to the obtained polymer to obtain a heat-sensitive adhesive.
【００１６】〔医療容器用シート〕紙基材として、アク
リル酸エステルを含浸させた含浸紙の片面に軽質炭酸カ
ルシウム、カオリンを塗工した含浸塗工紙（印刷用含浸
塗工紙，８５．０ｇ／ｍ2安倍川製紙製）を用いた。こ
の含浸塗工紙の軽質炭酸カルシウム、カオリンを塗工し
ていない面に、得られた感熱性接着剤を乾燥重量で２０
ｇ／ｍ2 となるように塗工し、医療容器用シートを得
た。[Sheet for medical container] As a paper base material, impregnated paper coated with light calcium carbonate and kaolin on one side of an impregnated paper impregnated with an acrylate ester (impregnated coated paper for printing, 85.0 g) / M 2 made by Abekawa Paper). The resulting heat-sensitive adhesive was applied on a surface of the impregnated coated paper not coated with light calcium carbonate and kaolin in a dry weight of 20%.
g / m 2 to obtain a sheet for a medical container.
【００１７】実施例２ 〔感熱性接着剤の製造〕メチルメタクリレート７５モル
％、２−エチルヘキシルメタクリレート２５モル％を十
分に窒素置換したセパラブルフラスコに仕込み、重合開
始剤の過酸化ラウロイルパーオキサイド０．１重量部を
攪拌しながら徐々に加え、窒素置換しながら６０℃、２
時間加熱して反応終了とする。これとは別に準備した塩
化ビニル／酢酸ビニル共重合体を３２モル％ブレンド
し、得られた重合物にオキシ酸エステルを２０重量％加
え、感熱性接着剤を得た。Example 2 [Production of a heat-sensitive adhesive] A separable flask was charged with 75 mol% of methyl methacrylate and 25 mol% of 2-ethylhexyl methacrylate in a nitrogen atmosphere, and lauroyl peroxide as a polymerization initiator was added. 1 part by weight was gradually added with stirring, and at 60 ° C.
Heat for a period of time to complete the reaction. Separately, 32 mol% of a vinyl chloride / vinyl acetate copolymer was blended, and 20% by weight of an oxyacid ester was added to the obtained polymer to obtain a heat-sensitive adhesive.
【００１８】〔医療容器用シート〕紙基材として、アク
リル酸エステルを含浸させた含浸紙の片面に軽質炭酸カ
ルシウム、水酸化アルミニウム、二酸化チタンを塗工し
た含浸塗工紙を用いる。この含浸塗工紙の軽質炭酸カル
シウム、水酸化アルミニウム、二酸化チタンを塗工して
いない面に、得られた感熱性接着剤を乾燥重量で２０ｇ
／ｍ2 となるように塗工し、医療容器用シートを得た。[Medical Container Sheet] As a paper substrate, an impregnated paper in which light calcium carbonate, aluminum hydroxide and titanium dioxide are coated on one side of an impregnated paper impregnated with an acrylate ester is used. On a surface of this impregnated coated paper not coated with light calcium carbonate, aluminum hydroxide and titanium dioxide, the obtained heat-sensitive adhesive was applied in an amount of 20 g by dry weight.
/ M 2 to obtain a sheet for a medical container.
【００１９】実施例３ 〔感熱性接着剤の製造〕メチルメタクリレート７５モル
％、２−エチルヘキシルメタクリレート２５モル％を十
分に窒素置換したセパラブルフラスコに仕込み、重合開
始剤の過酸化ラウロイルパーオキサイド０．１重量部を
攪拌しながら徐々に加え、窒素置換しながら６０℃、２
時間加熱して反応終了とする。これとは別に準備した塩
化ビニル／酢酸ビニル共重合体を３２モル％ブレンド
し、得られた重合物にオキシ酸エステルを２重量％加
え、感熱性接着剤を得た。Example 3 [Production of a heat-sensitive adhesive] A separable flask was charged with 75 mol% of methyl methacrylate and 25 mol% of 2-ethylhexyl methacrylate in which nitrogen was sufficiently substituted, and a polymerization initiator, lauroyl peroxide, was added. 1 part by weight was gradually added with stirring, and at 60 ° C.
Heat for a period of time to complete the reaction. 32 mol% of a separately prepared vinyl chloride / vinyl acetate copolymer was blended, and 2% by weight of an oxyacid ester was added to the obtained polymer to obtain a heat-sensitive adhesive.
【００２０】〔医療容器用シート〕紙基材として、アク
リル酸エステルを含浸させた含浸紙の片面に軽質炭酸カ
ルシウム、水酸化アルミニウム、二酸化チタンを塗工し
た含浸塗工紙を用いる。この含浸塗工紙の軽質炭酸カル
シウム、水酸化アルミニウム、二酸化チタンを塗工して
いない面に、得られた感熱性接着剤を乾燥重量で２０ｇ
／ｍ2 となるように塗工し、医療容器用シートを得た。[Medical Container Sheet] As a paper base material, an impregnated paper in which light calcium carbonate, aluminum hydroxide, and titanium dioxide are applied on one side of an impregnated paper impregnated with an acrylate ester is used. On a surface of this impregnated coated paper not coated with light calcium carbonate, aluminum hydroxide, and titanium dioxide, the obtained heat-sensitive adhesive was dried in an amount of 20 g.
/ M 2 to obtain a sheet for a medical container.
【００２１】比較例１ 〔感熱性接着剤の製造〕メチルメタクリレート６０モル
％、イソブチルメタクリレート４０モル％を十分に窒素
置換したセパラブルフラスコに仕込み、重合開始剤のア
ゾビスイソブチロニトリル（ＡＩＢＮ）０．１重量部を
攪拌しながら徐々に加え、窒素置換しながら６０℃、２
時間加熱して反応終了とする。得られた重合体にオキシ
酸エステル１２重量％加え、感熱性接着剤を得た。Comparative Example 1 [Production of heat-sensitive adhesive] A separable flask in which 60 mol% of methyl methacrylate and 40 mol% of isobutyl methacrylate were sufficiently substituted with nitrogen was charged, and azobisisobutyronitrile (AIBN) as a polymerization initiator was charged. 0.1 parts by weight were gradually added with stirring, and at 60 ° C.,
Heat for a period of time to complete the reaction. 12% by weight of oxyacid ester was added to the obtained polymer to obtain a heat-sensitive adhesive.
【００２２】〔医療容器用シート〕紙基材として、アク
リル酸エステルを含浸させた含浸紙の片面に軽質炭酸カ
ルシウム、カオリンを塗工した含浸塗工紙を用いる。こ
の含浸塗工紙の軽質炭酸カルシウム、カオリンを塗工し
ていない面に、得られた感熱性接着剤を乾燥重量で２０
ｇ／ｍ2 となるように塗工し、医療容器用シートを得
た。[Sheet for Medical Container] As a paper substrate, an impregnated paper in which light calcium carbonate and kaolin are coated on one side of an impregnated paper impregnated with an acrylate ester is used. The obtained heat-sensitive adhesive was applied on a surface of the impregnated coated paper not coated with light calcium carbonate and kaolin in a dry weight of 20%.
g / m 2 to obtain a sheet for a medical container.
【００２３】比較例２ 〔感熱性接着剤の製造〕メチルメタクリレート５０モル
％、塩化ビニル５０モル％を十分に窒素置換したセパラ
ブルフラスコに仕込み、重合開始剤のアゾビスイソブチ
ロニトリル（ＡＩＢＮ）０．１重量部を攪拌しながら徐
々に加え、窒素置換しながら５０℃、４時間加熱して反
応終了とする。得られた重合体にオキシ酸エステル１２
重量％加え、感熱性接着剤を得た。Comparative Example 2 [Production of a heat-sensitive adhesive] A separable flask was charged with 50 mol% of methyl methacrylate and 50 mol% of vinyl chloride in which nitrogen was sufficiently substituted, and azobisisobutyronitrile (AIBN) as a polymerization initiator was charged. 0.1 parts by weight was gradually added with stirring, and the reaction was completed by heating at 50 ° C. for 4 hours while replacing with nitrogen. Oxyacid ester 12 was added to the obtained polymer.
By weight, a heat-sensitive adhesive was obtained.
【００２４】〔医療容器用シート〕紙基材として、アク
リル酸エステルを含浸させた含浸紙の片面に軽質炭酸カ
ルシウム、カオリンを塗工した含浸塗工紙を用いる。こ
の含浸塗工紙の軽質炭酸カルシウム、カオリンを塗工し
ていない面に、得られた感熱性接着剤を乾燥重量で２０
ｇ／ｍ2 となるように塗工し、医療容器用シートを得
た。[Sheet for Medical Container] As a paper substrate, an impregnated paper in which light calcium carbonate and kaolin are coated on one side of an impregnated paper impregnated with an acrylate ester is used. The resulting heat-sensitive adhesive was applied on a surface of the impregnated coated paper not coated with light calcium carbonate and kaolin in a dry weight of 20%.
g / m 2 to obtain a sheet for a medical container.
【００２５】比較例３ 〔感熱性接着剤の製造〕塩化ビニル／酢酸ビニル共重合
体（モル比率９０：１０）のみを用いた。これにリン酸
エステル１５重量％加え、感熱性接着剤を得た。 〔医療容器用シート〕紙基材として、アクリル酸エステ
ルを含浸させた含浸紙の片面に軽質炭酸カルシウム、水
酸化アルミニウム、二酸化チタンを塗工した含浸塗工紙
を用いる。この含浸塗工紙の軽質炭酸カルシウム、カオ
リンを塗工していない面に、得られた感熱性接着剤を乾
燥重量で２０ｇ／ｍ2 となるように塗工し、医療容器用
シートを得た。Comparative Example 3 [Production of heat-sensitive adhesive] Only a vinyl chloride / vinyl acetate copolymer (molar ratio: 90:10) was used. To this was added 15% by weight of a phosphoric ester to obtain a heat-sensitive adhesive. [Medical container sheet] As a paper base material, an impregnated paper in which light calcium carbonate, aluminum hydroxide, and titanium dioxide are coated on one surface of an impregnated paper impregnated with an acrylate ester is used. The resulting heat-sensitive adhesive was applied to a surface of the impregnated coated paper not coated with light calcium carbonate and kaolin so that the dry weight became 20 g / m 2 to obtain a sheet for a medical container. .
【００２６】「評価」上記の方法で得られた医療容器用
シートの感熱性接着剤面を軟質塩ビ製血液バック（ＫＢ
Ｑ−４００ＡＭ７１，川澄化学工業（株）製）に圧接
（１１０℃×２ｋｇ／ｃｍ2 ×２秒）し、直後接着力、
１ヶ月後接着力、耐冷凍性、耐温水解凍性、高圧蒸気滅
菌処理後のラベルの外観を評価した。[Evaluation] The surface of the heat-sensitive adhesive of the sheet for medical container obtained by the above-mentioned method was applied to a soft PVC blood bag (KB).
Q-400AM71, manufactured by Kawasumi Chemical Industry Co., Ltd. (110 ° C. × 2 kg / cm 2 × 2 sec.)
After one month, the adhesive strength, freezing resistance, hot water thawing resistance, and appearance of the label after high-pressure steam sterilization were evaluated.
【００２７】〔直後接着力〕圧接後２２℃／６５％ＲＨ
雰囲気中に２時間放置し、強固な接着力を持たせた。接
着力の測定はテンシロン万能試験機（ＲＴＣ−１２１
０，（株）ＯＲＩＥＮＴＥＣ製）を用い、３００ｍｍ／
ｍｉｎの速さで１８０゜剥離力を測定し、接着力を評価
した。[Adhesive force immediately after] 22 ° C / 65% RH after pressure welding
It was left in the atmosphere for 2 hours to give a strong adhesive force. The measurement of the adhesive force was performed using a Tensilon universal tester (RTC-121).
0, manufactured by ORIENTEC) at 300 mm /
The 180 ° peel force was measured at a speed of min, and the adhesive force was evaluated.
【００２８】〔１ヶ月後接着力〕同様に圧接した後、１
ヶ月間／２２℃６５％ＲＨの条件で放置した。その後、
直後接着力の方法と同様にして、１８０゜剥離力を測定
し、接着力を評価した。[Adhesive strength after one month]
It was left under conditions of months / 22 ° C. and 65% RH. afterwards,
Immediately after, 180 ° peeling force was measured in the same manner as in the method of adhesive force, and the adhesive force was evaluated.
【００２９】〔耐冷凍性〕血液バックに圧接したシート
を−３０℃で１週間冷凍保存した後のラベルの貼着性を
目視評価した。[Freezing resistance] After the sheet pressed against the blood bag was frozen and stored at -30 ° C for one week, the sticking property of the label was visually evaluated.
【００３０】〔耐温水解凍性〕また冷凍後、３７℃の温
水で１０分間解凍した後のラベルの貼着性を同様に目視
評価した。[Temperature resistance to warm water thawing] Further, after freezing, the sticking property of the label after thawing in warm water of 37 ° C for 10 minutes was similarly visually evaluated.
【００３１】〔高圧蒸気滅菌処理後の気泡の有無〕ま
た、高圧蒸気滅菌処理後、２２℃／６５％ＲＨ雰囲気中
に２時間放置し、シート端部の剥がれ、血液バックとシ
ートの間の気泡の有無を目視評価した。[Presence or absence of air bubbles after high-pressure steam sterilization] After high-pressure steam sterilization, the sheet was left in an atmosphere of 22 ° C./65% RH for 2 hours to peel off the end of the sheet and to remove air bubbles between the blood bag and the sheet. Was visually evaluated.
【００３２】[0032]
【表１】 [Table 1]
【００３３】このように、各実施例で得られたシート
は、医療容器用シートとして優れた性質を有するもので
あった。一方、比較例１は、１ヶ月後の接着力が不足
し、血液バックとシートの間で剥離が起こった。また耐
冷凍性、温水解凍性が不十分であり、シート端部に剥が
れを生じた。更に高圧蒸気滅菌後シートと血液バックの
間に気泡が入り込み外観が悪かった。比較例２は、１ヶ
月後の接着力が不足し、血液バックとシートの間で剥離
が起こった。また耐冷凍性、温水解凍性が不十分であ
り、シート端部に剥がれが生じた。更に高圧蒸気滅菌後
シートと血液バックの間に気泡が入り込み外観が悪かっ
た。比較例３は、直後、１ヶ月後の接着力が不足し、血
液バックとシートの間で剥離が起こった。また、耐冷凍
性、温水解凍性が不十分であり、シート端部に剥がれが
生じた。Thus, the sheets obtained in each of the examples had excellent properties as sheets for medical containers. On the other hand, in Comparative Example 1, the adhesive strength after one month was insufficient, and peeling occurred between the blood bag and the sheet. In addition, the freezing resistance and the hot water thawing property were insufficient, and the sheet edge peeled off. Further, air bubbles entered between the sheet and the blood bag after high-pressure steam sterilization, and the appearance was poor. In Comparative Example 2, the adhesive strength after one month was insufficient, and peeling occurred between the blood bag and the sheet. Further, freezing resistance and hot water thawing property were insufficient, and peeling occurred at the sheet edge. Further, air bubbles entered between the sheet and the blood bag after high-pressure steam sterilization, and the appearance was poor. In Comparative Example 3, immediately after one month, the adhesive strength was insufficient, and peeling occurred between the blood bag and the sheet. In addition, the freezing resistance and the hot water thawing property were insufficient, and the sheet edge peeled off.
【００３４】[0034]
【発明の効果】このように、アクリル系共重合樹脂と塩
化ビニル／酢酸ビニル共重合樹脂を主成分とする感熱性
接着剤を用いることにより、血液バックなどの可とう性
容器に対しても経時による接着力の低下がなく、さらに
高圧蒸気滅菌処理後にシートと血液バックの間に気泡が
入らなく、強固に接着させることができる医療容器用シ
ートを提供することができる。As described above, the use of a heat-sensitive adhesive mainly composed of an acrylic copolymer resin and a vinyl chloride / vinyl acetate copolymer resin enables the passage of time to a flexible container such as a blood bag. Thus, it is possible to provide a sheet for a medical container that can be firmly adhered without causing a decrease in adhesive force due to the above and without bubbles entering between the sheet and the blood bag after the high-pressure steam sterilization treatment.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ Ｇ０９Ｆ 3/02 Ｇ０９Ｆ 3/10 Ｃ 3/10 Ａ６１Ｊ 1/00 ３９０Ｑ ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification code FI G09F 3/02 G09F 3/10 C 3/10 A61J 1/00 390Q
Claims (2)
塩化ビニル／酢酸ビニル系共重合樹脂を主成分とする感
熱性接着剤を塗工したことを特徴とする医療容器用シー
ト。1. A sheet for a medical container, wherein a heat-sensitive adhesive mainly composed of an acrylic copolymer resin and a vinyl chloride / vinyl acetate copolymer resin is applied to one surface of a paper base material.
ビニル系共重合樹脂から成る感熱性接着剤に５〜１５重
量％の可塑剤を加えた請求項１記載の医療容器用シー
ト。2. The medical container sheet according to claim 1, wherein 5 to 15% by weight of a plasticizer is added to a heat-sensitive adhesive comprising an acrylic copolymer resin and a vinyl chloride / vinyl acetate copolymer resin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8325389A JPH10158607A (en) | 1996-12-05 | 1996-12-05 | Sheet for medical container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8325389A JPH10158607A (en) | 1996-12-05 | 1996-12-05 | Sheet for medical container |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH10158607A true JPH10158607A (en) | 1998-06-16 |
Family
ID=18176296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8325389A Pending JPH10158607A (en) | 1996-12-05 | 1996-12-05 | Sheet for medical container |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH10158607A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100452559B1 (en) * | 2001-12-06 | 2004-10-14 | 주식회사 엘지화학 | Adhesive composition for Aluminum Plate |
-
1996
- 1996-12-05 JP JP8325389A patent/JPH10158607A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100452559B1 (en) * | 2001-12-06 | 2004-10-14 | 주식회사 엘지화학 | Adhesive composition for Aluminum Plate |
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