JPH10158125A - Agent for preventing damage of hair and production of damaged model hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair damage-preventing agent containing a specific organic silicon compound. SOLUTION: This hair damage-preventing agent contains 0.01-10wt.% of one or more kinds of compounds selected from among a lower alkyl silanol of the formula: RnSi(OH)4-n [R is a 1-4C alkyl; (n) is 1 to 2] (e.g. dimethylsilanediol) and a lower alkyl silanol peptide derivative of the formula (the mol.wt. of the peptide portion is about 100-10,000), or the compound and 0.1-10wt.% of one or more kinds of polymeric compounds selected from among a cationic polymer compound (e.g. quaternary trimethylammonium derivative cellulose), an amphoteric polymer compound (e.g. Yukaformer-AM-75), a nonionic polymer compound (e.g. polyvinyl pyrrolidone) and a silicone polymer compound (e.g. an amino-modified silicone-graft copolymer). The hair damage-preventing agent can prevent the real fuzzing and cracking of hair.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair damage preventing agent which can effectively prevent hair damage troubles such as fluffing and cracking of hair, and a method of preparing damaged model hair.

[0002]

2. Description of the Related Art Due to an increase in fashionable consciousness, many adult women have been subjected to chemical treatments such as perm, hair bleach and hair coloring. As a reaction due to their use, loss of luster of hair, dryness,
It causes damage troubles such as split ends and broken hairs. Hair is a dead tissue and cannot be self-repaired.In addition, once damage begins, the progress of the damage is accelerated in daily life such as shampooing, brushing, and using a dryer. Is a serious problem.

[0003] Conventionally, as a method for preventing the generation of split ends, the surface of hair is coated with a film-forming substance such as a cationic activator, a high molecular compound, or a liquid oil to reduce the frictional force in the cuticle layer and to perform brushing. Attempts have been made to suppress the peeling damage and to reinforce the strength of the hair at the time (Japanese Patent Laid-Open No. 57-88).
111, JP-A-5-85921, JP-A-6-505
No. 973). Also, a method of penetrating and replenishing hair with a decomposition product and a derivative such as collagen and keratin similar to the hair component for the purpose of repairing the damaged part has been proposed (Japanese Patent Application Laid-Open No. 57-88109, Japanese Patent Application Laid-Open No. 2-53712). No.)
However, it is still not enough.

On the other hand, as a method of searching for an agent for preventing hair damage, for example, in the evaluation of the occurrence of split ends, a method using an automatic brushing device that matches the actual behavior has been proposed (Arai et al., Cosmetic Magazine, 29 (2) , 125 (199
5)), however, there are differences in the damage state between the hairs used and the degree of damage in the same hair, and the number of hairs is considerably large. However, there is also a problem with the variation in the evaluation, and the development of a simpler and more quantitative evaluation system has been demanded.

As described above, there has been a strong demand for the development of a simple and highly quantitative evaluation system for hair damage preventive agents, and the development of hair damage preventive agents excellent in hair damage preventing or repairing effects.

SUMMARY OF THE INVENTION The present invention has been made to meet the above-mentioned demand, and is intended to produce a damaged model hair in which crack damage is easily caused, and a hair damage preventive agent capable of preventing hair troubles such as hair fluffing and cracks. The purpose is to provide.

[0007]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, after collecting a predetermined amount of cortex protein species of hair,
It is found that, when the damaged model hair produced by the oxidation treatment is freeze-dried, cracks are frequently generated in the hair, and lower alkyl silanols represented by the following general formula [I] and / or those represented by the following general formula [II] Peptide derivatives,
Alternatively, by using a combination of these lower alkylsilanols and / or their peptide derivatives with a cationic polymer compound, an amphoteric polymer compound, a nonionic polymer compound and a silicone polymer compound, the above-mentioned damaged model hair preparation The present inventors have found that an excellent hair damage preventing effect can be obtained in an experimental system based on the method described above, and that the hair can be prevented from fluffing and cracking, and the present invention has been completed.

Accordingly, the present invention provides a lower alkyl silanol represented by the following general formula [I] and a lower alkyl silanol represented by the following general formula [II]
One or more kinds of organosilicon compounds selected from peptide derivatives of lower alkylsilanols represented by, or this organosilicon compound and a cationic polymer compound,
An agent for preventing hair damage, comprising one or more polymer compounds selected from an amphoteric polymer compound, a nonionic polymer compound and a silicone polymer compound.

[0009]

Embedded image (In the formula, R is a linear or branched alkyl group having 1 to 4 carbon atoms, n is 1 or 2, and peptide is a peptide residue having a molecular weight of 100 to 10,000.)

Further, the present invention provides a hair cortex protein comprising one or more anionic surfactants selected from alkyl sulfates, alpha-olefin sulfonates and alkyl benzene sulfonates;
Preparation of damaged model hair characterized by eluting in a solution with one or more reducing agents selected from mercaptoethanol, dithiothreitol and thioglycolic acid, oxidizing, and then lyophilizing Provide the law.

Hereinafter, the present invention will be described in more detail.
The hair damage preventive agent of the present invention comprises one or more of lower alkyl silane triols or di-lower alkyl silane diols represented by the following general formula [I] or peptide derivatives thereof represented by the following general formula [II] As an active ingredient.

[0012]

Embedded image (In the formula, R is a linear or branched alkyl group having 1 to 4 carbon atoms, n is 1 or 2, and peptide is a peptide residue having a molecular weight of 100 to 10,000.)

Such a lower alkylsilane triol or di-lower alkylsilane diol hydrolyzes the corresponding alkoxysilane or hydrolyzes the corresponding chlorosilane and dissolves in a concentrated aqueous sodium hydroxide solution to form an acid or a cation. It can be easily prepared by a method such as neutralization with an ion exchange resin, for example, dimethylsilanediol, methylsilanetriol, diethylsilanediol, ethylsilanetriol, dipropylsilanediol, propylsilanetriol, diisopropylsilane Diol, isopropylsilanetriol, dibutylsilanediol, butylsilanetriol, diisobutylsilanediol, isobutylsilanetriol,
Examples thereof include di (sec-butyl) silanediol, sec-butylsilanetriol, di (tert-butyl) silanediol, and tert-butylsilanetriol. In addition, these peptide derivatives can be prepared by a general binding reaction with protein decomposed products such as collagen, elastin, keratin, silk, milk, soybean, and wheat prepared by various methods. It is a compound that is commercially available under a name such as (chemical formation) and can be easily obtained. The molecular weight of the peptide portion of the peptide derivative is about 100 to 10,000, especially about 1,000.
Those having 0 or less are preferable. In addition, it can be used in the form of amphoteric and cationized in accordance with the improvement of the adsorptivity, the product dosage form, the use form and the like.

The amount of the above-mentioned organosilicon compound (lower alkylsilanol of the formula [I] and its peptide derivative) is not particularly limited.
% (% By weight, the same applies hereinafter), and more preferably 0.05 to 5%.

The above-mentioned organosilicon compound may be used alone as an active ingredient. However, a cationic polymer compound, an amphoteric polymer compound, a nonionic polymer compound and a silicone polymer compound may be added to the organosilicon compound. It is preferable to use one or two or more polymer compounds selected from the above in combination, since the effect of preventing hair damage is high.

Examples of the cationic high molecular compound used in combination include quaternary trimethylammonium-derived cellulose, quaternary trimethylammonium-derived guar gum, and quaternary trimethylammonium-derived starch. It is a component that is commercially available under such a name and is easily available.

Examples of the amphoteric polymer compound include octylamide acrylate, hydroxypropyl acrylate,
Butylaminoethyl methacrylate copolymer, N-methacryloyloxyethyl N, N-dimethylammonium-
α-N-methylcarboxybetaine / alkyl methacrylate copolymer and the like are commercially available under the names of Unformer 28-4910 and Yuka Former AM-75, and are readily available components.

Examples of the nonionic polymer compound include polyvinylpyrrolidone, polyvinylpyrrolidone / vinyl acetate copolymer, etc., which are commercially available under the names of PVP and rubiscol and are readily available components.

As the silicone polymer compound, amino-modified, cationized and amphoteric silicone graft polymers can be used.

The content of these high molecular compounds is not particularly limited, but is usually selected in the range of 0.1 to 10%, preferably 0.5 to 5% in the damage inhibitor.

The hair damage preventive of the present invention may contain, as required, various additives commonly used in conventional hair cosmetics, in addition to the above-mentioned essential components, as long as the object of the present invention is not impaired. be able to.

The additional components include, for example, cationic surfactants, anionic surfactants, nonionic surfactants, amphoteric surfactants, organic acids such as citric acid and succinic acid and salts thereof, and sterilizers. Agents, UV absorbers, antioxidants, higher alcohols, hydrocarbons, ester oils, fatty acids, colorants, fragrances, solubilizers such as ethyl carbitol, isoprene glycol, penetration enhancers such as benzyl alcohol, ethylene glycol, propylene Examples include humectants such as glycol, sorbitol, glycerin and amino acids, and solvents such as ethanol and water.

The hair damage preventing agent of the present invention can be widely used in many product forms such as, for example, liquid, foam, spray, gel and cream.

Here, a method for evaluating the effect of the hair damage inhibitor of the present invention will be described. According to the study of the present inventors, hair cortex protein species can be converted into alkyl sulfate, alpha-olefin sulfonate and Elution in a solution of one or more anionic surfactants selected from alkylbenzene sulfonates and one or two or more reducing agents selected from 2-mercaptoethanol, dithiothreitol and thioglycolic acid After that, by performing an oxidation treatment, and then freeze-dried,
A damaged model hair with many cracks is produced, and in this case, the hair after the oxidation treatment is treated with a damage inhibitor and then freeze-dried to reduce some of the cracks generated by the damaged model hair. It has been found that the degree of the effect of the hair damage inhibitor can be easily and reliably evaluated by comparing with a crack.

The damaged model hair prepared by collecting a predetermined amount of cortex protein species of the hair and subjecting it to oxidation treatment is
The reason why the hair often cracked when freeze-dried is to analyze the history of hair, such as perm, hair bleach, and hair color treatment, and clarify the relationship between damage troubles and damaged parts (cosmetics (The 38th Annual Meeting of the Engineers' Meeting, the 38th Annual Meeting of the Society of Biochemistry, Japan), modeled those damaged parts and reproduced the damaged state close to the tip of the hair damaged by actual perm treatment. It is considered that many cracks were easily formed by freeze-drying as in the case of damaged hair.

In the following, this point will be described in more detail. In the preparation of a damaged model hair in which cracks frequently occur in the above-mentioned freeze-dried hair, an anionic active agent having a protein denaturing effect used for eluting hair cortex protein species. For example, alkyl sulfate (AS), alpha-olefin sulfonate (AOS), alkylbenzene sulfonate (LAS) and the like are suitable.

These anionic activators having a protein denaturing action can be used alone or in combination of two or more. The amount of the anionic activator in the treatment solution is 0.3 to 3%, especially 0.5 to 3%. A range of 2% is preferred.

Next, as the reducing agent, thioalcohols such as thioglycolic acid, 2-mercaptoethanol and dithiothreitol are preferably used. These reducing agents can be used alone or in combination of two or more. The content of the reducing agent in the treatment solution at the time of collecting the hair cortex protein species depends on the solubility of the reducing agent used, but is 0.01 to 40%, particularly 0.05 to 40%.
The treatment is preferably carried out in the range of 30%, especially in the range of 0.8 to 15% for thioglycolic acid, 1 to 10% for 2-mercaptoethanol, and 0.05 to 10% for dithiothreitol. Is preferred. If the content of these reducing agents is less than the above range, the reduction of the S--S bond of the hair keratin protein species may be insufficient and the intended purpose may be difficult to achieve, while the content of the reducing agent is above the above range. If it exceeds the range, the collection efficiency may be lowered, which is considered to be due to poor solubility of the microfibril protein in the hair cortex.

The amount of the hair cortex protein species collected in a solution containing an anionic activator having a protein denaturing action and a reducing agent is in the range of 0.01 to 10% (based on hair weight). In order to cause crack generation by freeze-drying quantitatively, extraction treatment is performed for 3 to 4 hours, and an extraction range of 4 to 6% of hair weight is particularly preferable.

On the other hand, the oxidizing agent to be used is not particularly limited as long as it can cause oxidative deterioration of the cuticle layer, but it is usually hydrogen peroxide used in the bleaching process or bromine used in the permanent 2 liquid. An appropriate amount of sodium acid is used. Freeze-drying can be adequately performed with general equipment and conditions.

[0031]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to examples, but the present invention is not limited to the following examples.

[Example 1] No chemical treatment 27
After the hair of 10 cm from the root of the old woman was defatted (chloroform: methanol = 2: 1), 1 mL of 25 mM Tris-glycine buffer (pH 8.3) was added to 10 mg of hair, and then 1% in final concentration. SDS to become
To a further 2.3% dithiothreitol (D
TT) was added, and an elution treatment was arbitrarily performed at 37 ° C. for 1 hour to 4 hours. After washing with water, 1 mL of 2% sodium bromate
Oxidation treatment was performed at room temperature for 5 minutes, frozen at -80 ° C for 2 hours, and further dried for 16 hours with a vacuum pump. The frequency of cracks generated at that time was observed by SEM electron microscope for about 20 hairs.
Table 1 shows the results. From this result, it was found that those subjected to the elution treatment for 3 to 4 hours had a high crack generation frequency, and could quantitatively prepare a crack damage model hair.

[0033]

[Table 1]

Example 2 Hair which had been subjected to an extraction treatment for 4 hours in the same manner as in Example 1 was oxidized and then immersed in a sample in which a compound shown in Table 2 was dissolved in a 20% ethanol solution.
C. for 15 minutes and then freeze-dried to evaluate the frequency of cracks. The fluff after the treatment was evaluated according to the following criteria. Table 2 shows the results. In addition, in the following examples, silanol was prepared by the following method.

Evaluation criteria for fluff ○: Little fluff is observed. Δ: Some fluffing is observed. ×: Remarkable fluffing is observed.

As an example of the preparation of silanol, a case where methylsilanetriol is prepared from methyltriethoxysilane will be described. 94.7 g of methyltriethoxysilane was weighed into a 2 L beaker, and 4 g of hydrochloric acid and ion-exchanged water were added to make a total of 1 kg. The mixture was stirred at room temperature for 6 hours at a stirring speed of 200 rpm using a stirring rod equipped with a 7 cm half-moon Teflon stirring blade. Initially, the mixture was separated into two layers when allowed to stand, but after the reaction was completed, a homogeneous aqueous solution was obtained.

From the results shown in Table 2, it was found that the combination of the lower alkylsilanols of the present invention and their peptide derivatives and high-molecular compounds markedly suppressed cracking and fluffing during freeze-drying.

[0038]

[Table 2]

[0039]

Industrial Applicability The hair damage inhibitor of the present invention effectively prevents hair damage troubles such as hair fluffing and cracks.

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Keiji Takeuchi 1-3-7, Honjo, Sumida-ku, Tokyo Inside Lion Corporation

Claims (2)

[Claims] 1. The following general formula [I] R_nSi (O H)_4-n [I] (wherein, R is a linear or branched alkyl having 1 to 4 carbon atoms)
The group, n, is 1 or 2. Lower alkyls represented by)
Lanol and the following general formula [II](Where R and n are the same as above, and peptide is
It is a peptide residue having a molecular weight of 100 to 10,000. )
A peptide derivative of lower alkylsilanol represented by
One or more organosilicon compounds selected from
Is the organic silicon compound and a cationic polymer compound,
Amphoteric polymer, nonionic polymer and silico
Or two or more high-molecular compounds selected from
Damage prevention for hair characterized by containing a molecular compound
Stopper. 2. The hair cortex protein species is one or two selected from alkyl sulfates, alpha-olefin sulfonates and alkyl benzene sulfonates.
After elution in a solution of one or more anionic surfactants and one or two or more reducing agents selected from 2-mercaptoethanol, dithiothreitol and thioglycolic acid, an oxidation treatment is performed, and then A method for producing damaged model hair, characterized by lyophilizing.