JPH10151176A - Infusion container for instillation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an infusion container for communicating a drug container and a dissolving fluid container to each other in a single operation. SOLUTION: The upper part of a container body 1 with a liquid delivery means 4 containing a dissolving fluid and an elastic plug 3 on a lower end for allowing a puncture with an infusion needle and an air supply needle, is provided with a first separation means 5 having the whole of both side areas inscribed to the inner surface of the container body 1 and thermally fused thereto, and formed to be broken upon exposure to external pressure or the like. Furthermore, the container body 1 with a dissolved fluid chamber of large capacity is laid under the first separation means, together with a holder 9 connected to the upper part of the container body 1 and formed to have an opening at a lower end and an intermediate separation part 1e made of an upper movable holder 9a and a lower fixed holder 9b, and an inverted vial 10 housed in the holder 9, jointed to the upper movable holder 9a as part of the holder 9 and formed to be capable of removing the second separation means 11 fitted to a mouth 10a on the vertical motion of the upper movable holder 9a for communication to the container body 1.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention belongs to the technical field of an infusion container for infusion.

[0002]

2. Description of the Related Art Conventionally, as an infusion container for infusion of this kind, a flexible container having a liquid passage portion containing a dissolving solution or a diluent therein and having a closed film at the uppermost end, A connected capsule, a medicine container whose mouth is sealed with a pierceable stopper, and held in the capsule; and a communication means for communicating between the inside of the flexible container and the inside of the medicine container. The communicating means comprises a hollow puncture needle having a hub in the middle and having a cutting edge at both ends, and after the stopper of the drug container is pierced by one of the puncture needles, the other blade of the puncture needle And a braking means for controlling the order of communication so that the closing membrane of the flexible container is pierced by the device. (See, for example, Japanese Patent Application Laid-Open No. 2-1277.) In such a conventional technique, since the means for communicating the inside of the flexible container with the inside of the medicine container is a hollow puncture needle, The amount of liquid flowing in and out is small, the dissolution rate of the drug is slow, and much time is required, and the structure is complicated, the cost is increased, and it is uneconomical.

Further, a container body made of a flexible resin film material is provided by a weak heat seal or the like, having a suspending means at an upper end, an elastic stopper at a lower end through which a drip needle and a ventilation needle can be pierced. The partitioning means is divided into a plurality of chambers by the partitioning means having easy peelability, and the partitioning means is easily formed by pressing the container body from outside at the time of use or pulling the resin film constituting the container body in the separating direction. There is known an infusion container for intravenous drip injection, which is peeled off to allow communication between the two chambers to dissolve the drug. (For example, Japanese Patent Publication No. 6-265
No. 63, JP-A-1-240469, JP-A-2-24069
-4671, JP-A-4-364850, JP-A-4-364851, and JP-A-6-14975. In such a conventional infusion container for drip injection, the container body is easily peeled off. The chamber is divided into a plurality of chambers such as a medicine chamber and a solution chamber by a partitioning means having a property. The partition means constituting this compartment is constituted by a heat-sealing portion which is weaker than other heat-sealing portions by changing the heat-sealing temperature of the resin films. In general, resin films have thickness variations, and when multiple layers are used, the thickness of each layer varies.Therefore, the welding temperature conditions in the weak heat sealing state resulting from these variations vary from resin film lot to lot. However, even in the same lot, these thickness variations occur in the portion of the wound resin film material. Also, in order to allow the partitioning means having easy peelability to communicate with a certain pressing force, the partitioning means, in particular, the welding pressure and temperature management of the weak heat seal portion become very complicated, and the medicine and the solution It is extremely unstable as a means of processing containers that guarantees long-term stable storage of the container. As described above, the formation of the partition means, that is, the weak heat seal portion, is very delicate, and when the weak heat seal portion has strong adhesion, it is not easily peeled off by a pressing or separating operation during use, and If the adhesion is weak, it may be unintentionally peeled off, which may lead to an accident that the infusion container becomes unusable.

An object of the present invention is to provide one-touch operation for communication between a drug container and a dissolving solution container, a large exchange of liquid between the two chambers, rapid dissolution of the drug, and an improvement in infusion efficiency. It is to provide an infusion container which can achieve the above.

[0005]

The object of the present invention is to provide a flexible resin in which a dissolving solution is accommodated inside and a discharge means having an elastic stopper at the lower end through which a drip injection needle and a ventilation needle can be pierced. On the upper part of the container body made of the material, the entire area of both side plate surfaces in contact with the inner surface of the flexible resin material constituting the container body is heat-welded,
A first isolating means which is destroyed by external pressure or the like, and a container body having a large-volume solution chamber formed below the first isolating means; And a holder longer than the vial composed of an upper movable holder and a lower fixed holder whose middle part is connected with a liquid-tight structure that can be compressed and deformed, and an upper movable part that is housed in the holder and constitutes this holder Achieved by the fact that the upper movable holder is connected to the holder, and the upper isolation holder is removed from the second isolation means attached to the bottle opening, so that the upper movable holder can communicate with the container body. Is done. The object of the present invention is to provide a method as set forth in claim 1, wherein the second isolating means is temporarily supported on the upper surface of a projection formed on the inner surface of the lower fixing holder, while the peripheral edge of the rubber inner plug which can be plugged into the bottle opening is lowered. Sometimes the periphery of the rubber plug corresponds to the underside of the projection,
This is achieved by the configuration in which the peripheral edge of the rubber inner plug engages with the lower surface of the projection and is removed from the bottle opening when the upper movable holder returns to the ascending position, so that the vial and the container body can communicate with each other. The object of the present invention is to provide a method as set forth in claim 1, wherein the second isolating means is provided on the upper surface of the projection formed on the inner surface of the lower fixed holder, the periphery of the cap fitted to the bottle opening is temporarily supported, and the lower limit of lowering of the upper movable holder is reduced. Occasionally, the peripheral edge of the cap corresponds to the lower surface of the protrusion, and when the upper movable holder rises and returns, the peripheral edge of the cap engages with the lower surface of the protrusion and is removed from the bottle opening so that the vial and the container body can communicate with each other. It is achieved by doing. The object of the present invention is to provide a method as set forth in claim 1, wherein the second isolating means is provided with a rubber stopper inserted into the vial, the periphery of the bottle opening being temporarily supported on the projection upper surface formed on the inner surface of the lower fixing holder. This is achieved by providing a pushing body for pushing up and pushing down on the lower bottom portion of the lower fixed holder so that the vial and the container body can communicate with each other by pushing in the rubber stopper. The above object is achieved by providing, in any one of claims 1 to 4, a filtering means for removing foreign substances above the elastic plug constituting the liquid discharging means.

[0006]

Embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a partially cutaway front view showing a first embodiment of the infusion container of the present invention, FIG. 2 is a partially cutaway enlarged front view showing a non-communicating posture of a vial, and FIG. 3 is a partially cutout enlarged view showing a vial communicating posture. FIG. 4 is a perspective view showing an example of the first isolating means, FIG. 5 is a longitudinal sectional side view of the partitioned state of the first isolating means, and FIG. 6 is a partially cutaway view showing a second embodiment of the infusion container. Front view, FIG. 7 is a partially cut-away enlarged front view showing a vial unconnected position, FIG. 8 is a partially cut-out enlarged front view showing a vial connected position, and FIG. 9 is a partial view showing a third embodiment of an infusion container. FIG. 10 is a partially cutaway enlarged front view showing a non-communicating posture of the vial, and FIG. 11 is a partially cutout enlarged front view showing a vial communicating posture.

The first embodiment of the present invention will be described in detail with reference to FIGS. A is an infusion container main body for drip injection. The infusion container main body A is composed of a container main body 1 in which a solution is stored and a medicine container 2 in which a vial connected to an upper portion thereof is stored. ing.

The container body 1 is formed by heat-sealing two flexible single-layer or composite resin films 1a. A drip injection needle (not shown) and a vent are provided at the lower end of the container body 1. Rubber stopper 3 through which needle (not shown) can be inserted
Is liquid-tightly heat-sealed 1c.

The entire width region inside the upper portion of the container body 1 is thermally welded 5a to both surfaces in contact with the inner surface of the resin film 1a constituting the container body 1, and is broken by external pressing force, impact force, or the like. In addition, the isolation member is isolated by a communication member 5 constituting a first isolation means, and a small-capacity empty chamber 6 is provided above the communication member 5, and a dissolving solution adapted to the amount of drug is provided below the communication member 5. Is formed in a dissolving solution chamber 7 for enclosing.

At the upper end of the discharge liquid 4, a filter member 8 is provided for removing foreign matter such as debris generated when the communication member 5 breaks and communicates. The filter member 8 can be provided with a sterilizing or sterilizing function by filtering bacteria or the like.

An example of the structure of the communication member 5 will be described with reference to FIGS. The communication member 5 must be made of a resin material that can be relatively easily broken by hand without using tools, and a material that does not damage the resin film 1a of the container body 1 due to debris at the time of breaking must be selected. There is. For this reason, in order to consolidate the destruction part in the center, the cross-sectional shape of the communication member 5 is M-shaped, N-shaped, or a piece of shogi piece. It is desirable to have a box shape in which the portion 5b is present and the bent easily destructible portion 5c is provided between the plate portions 5b. Further, a heat welding 5 is provided at both ends of the communication member 5.
In order to establish a, an inclined surface 5d having both ends in a knife edge shape is formed. The shape and structure of the communication member 5 are not limited to the illustrated embodiment, since the shape and structure of the communication member 5 can be easily broken even if they are not shown.

The medicine container 2 connected to the upper side of the container body 1 is connected to the medicine container 2 by a heat seal 1b of the resin film 1a, and has an upper movable holder 9a having a cylindrical cap structure and a lower fixed holder. 9b is accommodated. Upper movable holder 9a
And the outer periphery of the lower fixed holder 9b are thermally welded 1d to the resin film 1a, respectively. Upper movable holder 9
a and the inner diameter of the upper half of the lower fixing holder 9b are substantially the same as the diameter of the vial 10 accommodated therein, and the lower half of the lower fixing holder 9b is slightly larger than the diameter of the vial 10a of the vial 10. Vial intervention cylinder 9c with open lower end
To form In addition, the vial 10a of the vial 10 is capped with a rubber stopper 11 that is integrally formed with a flange 11a that is removable and has a slightly larger outer diameter than the vial 10a and a diameter slightly smaller than the vial intervention cylinder 9c. ing. Reference numeral 9d denotes a ring-shaped ridge formed on the inner surface of the upper movable holder 9a. The ridge 10d is engaged with a concave groove 10b formed in the vial 10. In the figure, 12 is a suspension ring, 1e is a resin film 1a.
Is a compressively deformable portion formed by

The vial intervention cylinder 9 constituting the holder 9
c, the inner peripheral surface of the flange 11a of the rubber plug 11 is engaged with the inner surface of the intermediate portion to temporarily support the vial 10 and the rubber plug 1
A projection 13 having an action of withdrawing the vial 1 from the bottle opening 10a is provided, and furthermore, the removed rubber plug 11 is prevented from intervening in the container body 1 around the lower end opening of the vial intervention cylinder 9c. A flange 9e is provided.

Upper movable holder 9 constituting holder 9
The length of the compression interval between the lower end of a and the upper surface of the lower fixed holder 9b, more specifically, the length of the compressively deformable portion 1e, is slightly larger than the distance between the projection 13 provided on the vial intervention cylinder 9c and the flange 9e. At the same time, the distance between the projection 13 and the flange 9e is formed larger than the thickness of the flange 11a of the rubber plug 11, so that the rubber plug 11 moves and the solution can easily flow.

[0015]

[Explanation of Handling] When injecting a drip into a patient, the container main body 1 is appropriately placed on a table, and the isolation of the first isolation means is released in this state. That is, when the palm of the hand is pressed against the communication member 5 attached to the container body 1 and pressed, the easily breakable portion 5c of the communication member 5 is destroyed, and the empty chamber 6 and the solution chamber 7 are separated.
Becomes a communication state. Next, the isolation of the second isolation means is released. That is, for example, when the lower fixed holder 9b is gripped by the left hand and the lowering operation is applied to the upper movable holder 9a by the right hand, the rubber plug 1 plugged into the vial 10a of the vial 10 is moved.
At the same time as 1 gets over the projection 13, the vial 10 descends until the lower surface of the rubber plug 11 comes into contact with the flange 9 e of the vial intervention cylinder 9 c. When the upper movable holder 9a is raised in this state, the protrusion 13
The peripheral edge of the portion 1a is locked, the rubber stopper 11 is prevented from returning upward, and the rubber stopper 11 is completely pulled out at the upper return limit of the vial 10, that is, at the position where it returns to the original position, as shown in FIG. After being removed, the inside of the vial 10 and the inside of the solution chamber 7 of the container body 1 are in communication with each other. The solution in the solution chamber 7 formed in the container body 1 flows into the vial 10, the drug is dissolved by the solution, and the obtained drug solution is instilled by a conventional method. At this time, foreign matter such as debris generated by destruction of the communication member 5, sliding down of the rubber plug 11, and withdrawal action from the bottle opening 10a are removed by the filter member 8
, And only the active drug component is instilled into a human body or the like.

The details of the second embodiment of the present invention will be described with reference to FIGS. The second embodiment is different from the first embodiment only in the cap structure applied to the vial opening of the vial, and the other structures are the same. A more detailed description will be omitted.

The vial intervention cylinder 9 constituting the holder 9
c, a projection 21 is provided on the upper part of the inner wall surface.
Cap 23 for inserting rubber stopper 22 into bottle opening 10a
And the outer peripheral edge of the top wall of the cap 23 is temporarily supported on the upper surface of the projection 21. In the figure, reference numeral 23a denotes a liquid passage, and 24 denotes a liquid passage formed between the outer periphery of the cap 43 and the wall surface of the vial intervention cylinder 9c.
In the second embodiment shown in FIGS. 6 to 8, the outer peripheral edge of the top wall of the cap 23 is temporarily supported on the upper surface of the projection 21. ) Is formed, and this step surface is temporarily supported by the projections 21.
Since the lowering and raising strokes of the vial 10 can be reduced, the temporary support portion of the cap 23 with respect to the projection 21 is not limited to that of the illustrated embodiment.

[0018]

[Explanation of Handling] When injecting a drip into a patient, the container main body 1 is appropriately placed on a table, and the isolation of the first isolation means is released in this state. That is, when the palm of the hand is pressed against the communication member 5 attached to the container body 1 and pressed, the easily breakable portion 5c of the communication member 5 is destroyed, and the empty chamber 6 and the solution chamber 7 are separated.
Becomes a communication state. Next, the isolation of the second isolation means is released. That is, for example, when the lower fixed holder 9b is grasped with the left hand and the lower movable holder 9a is lowered with the right hand, the cap 2 covering the vial 10a of the vial 10 is moved.
At the same time as the peripheral edge of 3
The vial 10 descends until the lower surface of 3 contacts the flange 9e of the vial intervention cylinder 9c. When the upper movable holder 9a is raised in this state, the cap 23
And the cap 23 is prevented from rising and returning, and the rubber stopper 22 and the cap 23 are completely closed as shown in FIG. Then, the inside of the vial 10 and the inside of the solution chamber 7 of the container body 1 are in communication with each other. The solution in the solution chamber 7 formed in the container body 1 is filled with the vial 10
Then, the drug is dissolved by the dissolving solution, and the obtained drug solution is instilled by an ordinary method. At this time, foreign matter such as debris generated by destruction of the communication member 5, sliding down of the cap 23, and withdrawal from the bottle opening 10a is completely removed by the filter member 8, and only the effective drug component is removed from the human body. Intravenous injection is given.

Next, referring to FIG. 9 to FIG.
The details of the embodiment will be described. In the third embodiment, unlike the first and second embodiments, the rubber stopper of the vial is pushed into the vial only by the lowering operation of the vial without removing and removing the rubber stopper or the cap. Since the other configuration is the same as that of each of the above-described embodiments, except that the configuration is different, that is, only the configuration of the second isolating means is different, detailed description is given by assigning the same reference numerals to the same structural portions. Omitted.

The vial intervention cylinder 9 constituting the holder 9
In the upper portion of the inner wall surface of the vial 10, a projection 31 is provided for temporarily supporting the periphery of the vial 10a of the vial 10. On the other hand, a rubber inner plug 32 which can be pushed into the vial 10a of the vial 10 is plugged, and the vial 10a is closed. A pusher 33 having a cylindrical structure smaller in diameter than the caliber is erected on the bottom wall of the vial intervention cylinder 9c. In the drawing, 9 f and 9 g are liquid passage holes formed inside and outside the pushing body 33.

[0021]

[Explanation of Handling] When injecting a drip into a patient, the container main body 1 is appropriately placed on a table, and the isolation of the first isolation means is released in this state. That is, when the palm of the hand is pressed against the communication member 5 attached to the container body 1 and pressed, the easily breakable portion 5c of the communication member 5 is destroyed, and the empty chamber 6 and the solution chamber 7 are separated.
Becomes a communication state. Next, the isolation of the second isolation means is released. That is, for example, when the lower fixed holder 9b is grasped with the left hand and the lower movable holder 9a is lowered with the right hand, the peripheral edge of the vial 10a of the vial 10 goes over the projection 31 and the center of the lower surface of the rubber plug 32 is Push body 3
3, the rubber inner plug 32 is pushed into the vial 10 by this action, and the vial 10 descends until the lower surface of the bottle opening 10a contacts the flange 9e of the vial intervention cylinder 9c. In this state, the inside of the vial 10 and the inside of the solution chamber 7 of the container body 1 are in communication. The solution in the solution chamber 7 formed in the container body 1 flows into the vial 10, and the drug is dissolved by the solution,
The obtained drug solution is instilled by a conventional method. At this time,
Foreign matter such as debris generated by the destruction of the communication member 5 and the pushing action of the rubber plug 32 is completely removed by the filter member 8, and only the effective drug component is injected by instillation into a human body or the like.

[0022]

According to the configuration of the present invention as described above,
The following effects can be obtained. (A) As long as the first and second isolation means are not simultaneously released, the drug and the solution do not interact with each other, so that the long-term storage effect of the drug and the solution can be reliably ensured by a simple configuration. (B) Foreign matter such as debris generated by the release of the first and second isolation means can be completely removed by the filter member, and there is no fear that the foreign matter is injected into the body.

[Brief description of the drawings]

FIG. 1 is a partially cutaway front view showing a first embodiment of the infusion container of the present invention.

FIG. 2 is a partially cutaway enlarged front view showing a non-communicating posture of a vial.

FIG. 3 is a partially cutaway enlarged front view showing a communicating posture of a vial.

FIG. 4 is a perspective view illustrating an example of a first isolation unit.

FIG. 5 is a vertical sectional side view of a partitioning state of the first isolating means.

FIG. 6 is a partially cutaway front view showing a second embodiment of the infusion container.

FIG. 7 is a partially cutaway enlarged front view showing a non-communicating posture of the vial.

FIG. 8 is a partially cutaway enlarged front view showing a communicating posture of the vial.

FIG. 9 is a partially cutaway front view showing a third embodiment of the infusion container.

FIG. 10 is a partially cutaway enlarged front view showing a non-communicating posture of the vial.

FIG. 11 is a partially cutaway enlarged front view showing a communicating posture of the vial.

[Explanation of symbols]

 A Infusion container main body 1 Container main body 1a Single layer or composite resin film 1b Heat seal 1c Heat welding 1d Heat welding 1e Compressible deformable part 2 Drug container 3 Rubber stopper 4 Discharge liquid 5 Communication member 5a Heat welding 5b Plate part 5c Fragility Part 5d Inclined surface 6 Vacancy 6a Bottle mouth 7 Dissolution liquid chamber 7a Flange 8 Filter member 9 Holder 9a Upper movable holder 9b Lower fixed holder 9c Vial intervention cylinder 9d Ring-shaped protrusion 9e Flange 9f Liquid passage 9g Liquid passage DESCRIPTION OF SYMBOLS 10 Vial 10a Bottle opening 11 Rubber stopper 11a Flange 12 Suspension ring 13 Projection 21 Projection 22 Rubber stopper 23 Cap 24 Liquid passage 31 Projection 32 Rubber stopper 33 Push body 43 Cap

Claims (5)

[Claims] 1. An upper portion of a container body made of a flexible resin material, in which a dissolving solution is accommodated and a discharging means having an elastic stopper body through which a drip injection needle and a ventilation needle can be pierced is provided at a lower end. ,
A first isolating means which is entirely welded to the inner surfaces of the flexible resin material constituting the container body and which is thermally welded and is destroyed by external pressure or the like is provided, and a first isolating means is provided below the first isolating means. An upper movable holder and a lower fixed holder that are connected to the upper part of the container body and have an opening at the lower end, and the middle part is connected with a liquid-tight structure that can be compressed and deformed. A holder which is longer than the vial to be constituted, and which is accommodated in the holder, is connected to the upper movable holder which constitutes the holder, and is provided with a second isolating means attached to the bottle opening for vertically moving the upper movable holder. An infusion container for drip injection, comprising: an inverted vial that is removed and can communicate with the container body. 2. The method according to claim 1, wherein the second isolating means comprises:
The periphery of the rubber plug that can be plugged into the bottle mouth is temporarily supported on the upper surface of the projection formed on the inner surface of the lower fixed holder, and the lower edge of the upper holder corresponds to the lower edge of the rubber plug at the lower limit of the upper holder, allowing the upper part to move At the time of return of the holder, the peripheral edge of the rubber inner plug engages with the lower surface of the projection and is removed from the bottle opening and removed.
An infusion container for drip injection, characterized in that the vial and the container main body can communicate with each other. 3. The method according to claim 1, wherein the second isolating means comprises:
On the upper surface of the projection formed on the inner surface of the lower fixed holder, the periphery of the cap fitted to the bottle opening is temporarily supported, and at the lower limit of the lowering of the upper movable holder, the periphery of the cap corresponds to the lower surface of the projection, An infusion container for drip injection, wherein the peripheral edge of the cap is engaged with the lower surface of the projection to be pulled out and removed from the vial at the time of returning to elevation, so that the vial and the container body can communicate with each other. 4. The method according to claim 1, wherein the second isolating means comprises:
On the upper surface of the projection formed on the inner surface of the lower fixing holder, the periphery of the bottle opening is temporarily supported, and a pusher that pushes up and pushes the rubber inner plug plugged into the bottle opening into the vial is provided at the lower bottom of the lower fixing holder, An infusion container for drip injection, characterized in that the vial and the container body can communicate with each other by pushing the inner stopper. 5. In any one of claims 1 to 4,
An infusion container for drip injection, characterized in that a filtering means for removing foreign substances is provided above the elastic stopper constituting the liquid discharging means.