JPH10120695A - Production of sesame lignan - Google Patents

Abstract

PROBLEM TO BE SOLVED: To efficiently produce a sesame lignan, having various physiological activities such as lowering actions on cholesterol and preventing actions on drunken sickness, useful as a healthy food, etc., and having high safety at a high concentration by carrying out the direct molecular distillation of a sesame oil. SOLUTION: Various sesame oils such as roasted oil, roasted and refined oil and raw pressed and refined oil are used as a raw material sesame oil and the direct molecular distillation thereof is carried out by using a falling film type molecular distilling machine at 150-270 deg.C temperature at <=0.1Torr vacuum degree to thereby efficiently afford the objective sesame lignan, having >3wt.% sesamin content, various physiological activities such as lowering actions on cholesterol and preventing actions on drunken sickness, capable of greatly expecting usefulness as a healthy food, etc., and used by crystallization and tableting with a suitable excipient, carrier or additive or formation into a granule and formulating in confectioneries, bread, sprinklings, paste products or edible oils, dressings, mayonnaise, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an efficient method for producing sesame lignan.

[0002]

2. Description of the Related Art Various kinds of sesame lignans are present in sesame seeds, and usually contain about 0.3 to 0.5% by weight of d-sesamin, as well as sesamol, sesamolin, It is known that sesaminol and the like are contained. Unrefined sesame oil squeezed from sesame seeds contains 0.5-0.5% of d-sesamin as sesame lignan.
It also contains about 1.0% by weight. Furthermore, unrefined sesame oil treated with a mineral acid such as sulfuric acid, activated clay, and the like contains episesmin, which is an optical rearrangement product of d-sesamin, as sesamin, in addition to d-sesamin. These sesame lignans, which are mainly composed of sesamin compounds, are known to have various physiological activities such as a cholesterol-lowering effect and a sickness-preventing effect, and are expected to be useful as health foods. Conventionally, as a method for producing sesame lignan, a method has been proposed in which sesame oil is extracted using an alcohol such as methanol, an organic solvent such as acetone, petroleum ether and acetonitrile, or a mixed solvent of these and water. However, this conventional method has the following problems.
1) The extract contains a considerable amount of glycerides other than sesamin, etc., and the sesamin content in the final product is low (about 1%
2) requires a large amount of organic solvent: 3) requires a large energy cost for distilling off the organic solvent; 4) is unsuitable for food hygiene and edible due to the residual solvent; Low.

[0003]

SUMMARY OF THE INVENTION The present invention provides a method for producing sesame lignan, which comprises subjecting sesame oil to molecular distillation. According to the method of the present invention, sesame oil can be efficiently obtained only by direct molecular distillation of sesame oil. In addition, it is possible to avoid contamination with glyceride or the like which is soluble in a solvent due to extraction with an organic solvent and to obtain a highly safe product, so that the problems of the conventional method can be completely solved.

[0004] In the method of the present invention, sesame oil obtained by a known method such as squeezing and pressing of sesame seeds can be used. The molecular distillation may be performed using a known molecular distillation machine. Specific examples include a falling film molecular distillation machine and a centrifugal molecular distillation machine. The conditions for the molecular distillation are arbitrary as long as the conditions are suitable for the distillation of sesame lignan from sesame oil, but the oil temperature is preferably 150 to 270 ° C., more preferably 18 to 270 ° C.
When the temperature is 0 to 250 ° C. and the degree of vacuum is 0.1 torr or less, more preferably 0.008 torr or less, the recovery of sesamin is improved to 80% or more, and the sesamin content is 3%.
It is possible to efficiently obtain a fraction containing sesame lignan containing a high concentration of sesamin, which is not less than about 10% by weight and reaches about 10% by weight. The fraction obtained in this way is
Alternatively, edible oil such as safflower oil may be blended into soft capsules to be used for health foods. It can also be used in general foods such as dressings and mayonnaise as sesamin-rich oil. Further, the above fraction may be purified by crystallization from an appropriate solvent such as ethanol, if desired. The crystals thus obtained can be tableted or formed into granules together with suitable excipients, carriers and additives, and used as health foods. In particular, the crystalline form of sesame lignan is suitable for blending into confectionery such as cookies and candies, bread, sprinkles, and paste products.

[0005]

The present invention will be described in more detail with reference to the following Examples, which do not limit the present invention. Example 1 Various sesame oils of roasted oil (1) (196.4 g), refined roasted oil (2) (163.4 g) and refined raw pressed oil (3) (181.2 g) were used as raw material sesame oil. . Using a falling film molecular distillation machine, the feed amount is 0.5 to 0.7 g /
The fraction was subjected to molecular distillation at an oil temperature of 230 ° C. and a degree of vacuum of 0.01 torr or less to obtain a fraction 1. Further, the feed amount was the same, the oil temperature was set to 250 ° C., and molecular distillation was performed at a degree of vacuum of 0.01 torr or less to obtain a fraction 2. The content of sesamin in the fraction 1, the fraction 2 and the residue was measured using high performance liquid chromatography under the following conditions. Column: ZOLBA x SIL 4.6 mmφ x
250 mm mobile phase: n-hexane: IPA: acetic acid = 99: 0.5:
0.5 Flow rate: 2.0 ml / min Detector: Spectral fluorescence spectro monitor Measurement wavelength: Ex (excitation wavelength) 295 nm Em (fluorescence wavelength) 330 nm. Table 1 shows the results. In addition, sesamin was calculated by the total of sesamin and episesamin.

[0006]

[Table 1] From the results in Table 1, the sesamin content of fractions 1 and 2 (%)
Is as low as 10% or less, but the sesamin
It turns out that it is 0% or more. In the present embodiment, the molecular distillation was performed twice at 230 ° C. and 250 ° C. However, in the case of industrialization, the distillation may be performed once at around 250 ° C. Also,
These fractions 1 and 2 also contain a large amount of sesamol and sesamolin, and the method of the present invention is a very efficient method for producing sesame lignan.

Example 2 A fraction 1 obtained by molecular distillation of the raw material (3) used in Example 1 under the same conditions is further subjected to direct molecular distillation under the same conditions, and the obtained fraction is reduced to about 2 It was dissolved in twice the volume of ethyl alcohol and left in a freezer at -20 ° C overnight. Then the crystals were filtered off and dried. Table 2 shows the results.

[Table 2] Similarly, by crystallizing other fractions, the sesamin content can be increased to 90% or more.

Claims (4)

[Claims] 1. A method for producing sesame lignan, comprising subjecting sesame oil to molecular distillation. 2. The method according to claim 1, wherein the molecular distillation is performed at a temperature of 150 to 270 ° C. and a degree of vacuum of 0.1 torr or less. 3. The process according to claim 1, wherein the sesame lignan has a sesamin content of 3% by weight or more. 4. Sesame lignan produced by the method according to claim 1.