JPH09500609A - 酸化窒素吸入の全身効果 - Google Patents
酸化窒素吸入の全身効果Info
- Publication number
- JPH09500609A JPH09500609A JP6522387A JP52238794A JPH09500609A JP H09500609 A JPH09500609 A JP H09500609A JP 6522387 A JP6522387 A JP 6522387A JP 52238794 A JP52238794 A JP 52238794A JP H09500609 A JPH09500609 A JP H09500609A
- Authority
- JP
- Japan
- Prior art keywords
- nitric oxide
- compound
- group
- administration
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 (1)酸化窒素および投与に際して治療に必要な有効量の酸化窒素を発生する化 合物との群から選択された化合物の治療に必要な有効量を、必要に応じ吸気経路 によって動物内に投与することにより、血小板の凝集または凝固を全身的に予防 または治療する方法。 (2)化合物が酸化窒素である請求の範囲第1項記載の方法。 (3)酸化窒素供与化合物が、S−ニトロソチオール、S−ニトロソタンパク質 、NONO硝酸塩、鉄ニトロシル、チオール酸リガンドを有する鉄ニトロシル類 、チオ亜硝酸塩、チオ硝酸塩、シドノニミン、フロクサン、ニトロソニウム塩、 有機硝酸塩および有機亜硝酸塩より成る群より選択されたものである請求の範囲 第1項記載の方法。 (4)酸化窒素および投与に際して治療に必要な有効量の酸化窒素を発生する化 合物との群から選択された化合物の治療に必要な有効量を、必要に応じて動物の 肺臓内に投与することにより、肺動脈の塞栓を予防または治療する方法。 (5)化合物が酸化窒素である請求の範囲第4項記載の方法。 (6)酸化窒素供与化合物が、S−ニトロソチオール、S−ニトロソタンパク質 、NONO硝酸塩、鉄ニトロシル、チオール酸リガンドを有する鉄ニトロシル類 、チオ亜硝酸塩、チオ硝酸塩、シドノニミン、フロクサン、ニトロソニウム塩、 有機硝酸塩および有機亜硝酸塩より成る群より選択されたものである請求の範囲 第4項記載の方法。 (7)酸化窒素および投与に際して治療に必要な有効量の酸化窒素を発生する化 合物との群から選択された化合物の治療に必要な有効量を、必要に応じ吸気経路 によって動物内に投与することにより、狭心症等の冠状動脈症候群を予防または 治療する方法。 (8)化合物が酸化窒素である請求の範囲第7項記載の方法。 (9)酸化窒素供与化合物が、S−ニトロソチオール、S−ニトロソタンパク質 、NONO硝酸塩、鉄ニトロシル、チオール酸リガンドを有する鉄ニトロシル類 、チオ亜硝酸塩、チオ硝酸塩、シドノニミン、フロクサン、ニトロソニウム塩、 有機硝酸塩および有機亜硝酸塩より成る群より選択されたものである請求の範囲 第7項記載の方法。 (10)酸化窒素および投与に際して治療に必要な有効量の酸化窒素を発生する 化合物との群から選択された化合物の治療に必要な有効量を、必要に応じ吸気経 路によって動物内に投与することにより、急性呼吸系の苦痛を伴う症候群を予防 または治療する方法。 (11)化合物が酸化窒素である請求の範囲第10項記載の方法。 (12)酸化窒素供与化合物が、S−ニトロソチオール、S−ニトロソタンパク 質、NONO硝酸塩、鉄ニトロシル、チオール酸リガンドを有する鉄ニトロシル 類、チオ亜硝酸塩、チオ硝酸塩、シドノニミン、フロクサン、ニトロソニウム塩 、有機硝酸塩および有機亜硝酸塩より成る群より選択されたものである請求の範 囲第10項記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/043,653 US5427797A (en) | 1993-04-06 | 1993-04-06 | Systemic effects of nitric oxide inhalation |
US08/043,653 | 1993-04-06 | ||
PCT/US1994/003561 WO1994022499A1 (en) | 1993-04-06 | 1994-03-31 | Systemic effects of nitric oxide inhalation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09500609A true JPH09500609A (ja) | 1997-01-21 |
JP3779726B2 JP3779726B2 (ja) | 2006-05-31 |
Family
ID=21928215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52238794A Expired - Lifetime JP3779726B2 (ja) | 1993-04-06 | 1994-03-31 | 薬剤組成物を製造するためのガス状酸化窒素の使用法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US5427797A (ja) |
EP (1) | EP0692984B2 (ja) |
JP (1) | JP3779726B2 (ja) |
CA (1) | CA2159915C (ja) |
DE (1) | DE69428351T3 (ja) |
WO (1) | WO1994022499A1 (ja) |
Families Citing this family (66)
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---|---|---|---|---|
DE10299002I1 (de) * | 1990-12-05 | 2012-07-05 | Gen Hospital Corp | Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion |
US5536241A (en) * | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
US5570683A (en) * | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
EP0676964B1 (en) * | 1991-11-14 | 2001-01-24 | Brigham And Women's Hospital | Nitrosylation of enzyme sh groups as a therapeutic modality |
US5910316A (en) * | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
ATE191560T1 (de) * | 1993-07-06 | 2000-04-15 | Aerocrine Ab | System zur feststellung von no-pegeln in ausgeatmeter luft und diagnostische verfahren für zu abnormalen no-pegeln in beziehung stehenden abweichungen |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US6911427B1 (en) | 1995-09-15 | 2005-06-28 | Duke University | No-modified hemoglobins and uses therefore |
US6855691B1 (en) | 1995-09-15 | 2005-02-15 | Duke University | Methods for producing and using S-nitrosohemoglobins |
US6197745B1 (en) | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
US6153186A (en) | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6627738B2 (en) * | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
US6916471B2 (en) * | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
ATE209922T1 (de) * | 1995-10-20 | 2001-12-15 | Air Liquide | Pharmazeutische zusammensetzung von stickstoffmonoxid |
US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
SE506778C2 (sv) * | 1996-08-12 | 1998-02-09 | Siemens Elema Ab | Förfarande vid blandning av gaser och en anordning för blandning av gaser |
US6057367A (en) | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
CA2225013C (en) | 1997-04-04 | 2006-06-06 | Institut Du N.O. Inc. | Injection system for delivery of a gaseous substance |
FR2762992B1 (fr) * | 1997-05-07 | 2000-08-25 | Air Liquide | Transporteurs de no a base de complexes polyazamacrocycles de fer et de cobalt |
US6656452B1 (en) | 1997-10-21 | 2003-12-02 | The General Hospital Corporation | Use of inhaled NO as anti-inflammatory agent |
US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
CA2254645A1 (en) * | 1998-11-23 | 2000-05-23 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
US6589759B1 (en) | 1999-03-30 | 2003-07-08 | Trustees Of Boston University | Compositions and methods for producing platelets and/or proplatelets from megakaryocytes |
US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
US6601580B1 (en) | 2000-06-28 | 2003-08-05 | The General Hospital Corporation | Enhancing therapeutic effectiveness of nitric oxide inhalation |
BRPI0113085B1 (pt) | 2000-08-11 | 2017-09-19 | R. Whitlock David | Preparation to be applied to a surface of an individual understanding ammonia oxidizing bacteria that metabolize transparation, and clothing article |
US7335181B2 (en) * | 2000-12-26 | 2008-02-26 | Pulmonox Technologies Corporation | Nitric oxide decontamination of the upper respiratory tract |
US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US7122018B2 (en) * | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
US6749834B2 (en) * | 2001-06-19 | 2004-06-15 | World Precision Instruments, Inc. | Methods and apparatus for therapeutic treatment of respiratory, cardiac and other pathologies |
US6676855B2 (en) * | 2001-08-02 | 2004-01-13 | Duke University | Use of a blood-flow decrease preventing agent in conjunction with insufflating gas |
US20040225275A1 (en) * | 2001-08-02 | 2004-11-11 | Reynolds James Dixon | Fetal physiology during maternal surgery or diagnosis |
AU2002326573B2 (en) * | 2001-08-20 | 2008-10-02 | University Of Louisville Research Foundation, Inc. | Use of S-nitrosothiol signaling to treat disordered control of breathing |
GB0125222D0 (en) * | 2001-10-19 | 2001-12-12 | Barts & London Nhs Trust | Composition for the treatment of microbial infections |
KR20040086267A (ko) * | 2002-01-11 | 2004-10-08 | 데이비드 알. 휘트록 | 암모니아 산화 박테리아를 포함하는 조성물 및 그를사용하는 방법 |
EP1514103A4 (en) * | 2002-05-29 | 2006-05-24 | Univ Duke | MEASUREMENT OF NITROGEN MONOXIDE IN HEMOTOXIC GASES, AND TREATMENT BASED ON THIS MEASURE |
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JP5564158B2 (ja) * | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
WO2005077005A2 (en) * | 2004-02-04 | 2005-08-25 | The General Hospital Corporation | Enhancing the effectiveness of an inhaled therapeutic gas |
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US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
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US20080193566A1 (en) * | 2007-02-09 | 2008-08-14 | Miller Christopher C | Use of high dose concentrations of gaseous nitric oxide |
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US9649467B2 (en) | 2008-01-31 | 2017-05-16 | Syk Technologies, Llc | Nitric oxide reactor and distributor apparatus and method |
US8434475B2 (en) | 2008-01-31 | 2013-05-07 | Genosys, Inc. | Nitric oxide reactor and distributor apparatus and method |
US8720436B2 (en) * | 2008-01-31 | 2014-05-13 | Genosys, Inc. | Nitric oxide gel apparatus and method |
US8501090B2 (en) * | 2008-03-24 | 2013-08-06 | Christian S. Minton | Anti-microbial gas apparatus and method |
JP6058888B2 (ja) * | 2008-07-24 | 2017-01-11 | ゲノ エルエルシー | 患者における心臓の病気の診断及び治療方法 |
US8685467B2 (en) | 2010-08-03 | 2014-04-01 | J. W. Randolph Miller | Nitric oxide generation, dilution, and topical application apparatus and method |
WO2013132499A1 (en) * | 2012-03-07 | 2013-09-12 | Advanced Inhilation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
US20160008394A1 (en) | 2013-02-28 | 2016-01-14 | Aires Pharmaceuticals, Inc. | Inorganic nitrite to improve cardiopulmonary hemodynamics |
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US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
EP4219679A3 (en) | 2014-04-15 | 2023-08-09 | Aobiome LLC | Ammonia-oxidizing nitrosomonas eutropha strain d23 |
WO2017132275A1 (en) | 2016-01-27 | 2017-08-03 | Syk Technologies, Llc | Nitric oxide topical application apparatus and methods |
US20180325908A1 (en) | 2017-01-10 | 2018-11-15 | United Therapeutics Corporation | Methods and compositions for treating pulmonary hypertension |
AU2020204681A1 (en) * | 2019-01-04 | 2021-08-05 | Bellerophon Therapeutics | Use of inhaled nitric oxide (INO) for improving activity levels in patients with lung-related conditions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10299002I1 (de) * | 1990-12-05 | 2012-07-05 | Gen Hospital Corp | Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion |
-
1993
- 1993-04-06 US US08/043,653 patent/US5427797A/en not_active Expired - Lifetime
-
1994
- 1994-03-31 JP JP52238794A patent/JP3779726B2/ja not_active Expired - Lifetime
- 1994-03-31 DE DE69428351T patent/DE69428351T3/de not_active Expired - Lifetime
- 1994-03-31 WO PCT/US1994/003561 patent/WO1994022499A1/en active IP Right Grant
- 1994-03-31 CA CA002159915A patent/CA2159915C/en not_active Expired - Lifetime
- 1994-03-31 EP EP94912377A patent/EP0692984B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5427797A (en) | 1995-06-27 |
CA2159915A1 (en) | 1994-10-13 |
DE69428351T3 (de) | 2012-03-15 |
EP0692984B1 (en) | 2001-09-19 |
CA2159915C (en) | 2002-01-08 |
DE69428351T2 (de) | 2002-04-18 |
EP0692984A1 (en) | 1996-01-24 |
EP0692984A4 (en) | 1998-07-01 |
EP0692984B2 (en) | 2011-08-24 |
WO1994022499A1 (en) | 1994-10-13 |
AU6496894A (en) | 1994-10-24 |
DE69428351D1 (de) | 2001-10-25 |
JP3779726B2 (ja) | 2006-05-31 |
AU690109B2 (en) | 1998-04-23 |
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