JPH09262285A - Infusion device and bag for liquid medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide the device that is reduced in size and weight for excellent portability, that is structured at low cost and that is also capable of infusion with details set such as the quantity of a liquid medicine, duration of infusion and intervals of infusion, arbitrarily in accordance with the state (condition or symptom) of a patient. SOLUTION: A liquid medicine cartridge 31, which stores a liquid medicine bag 32 and which contains a pressure chamber to be connected to a pressurizing means 51, is joined to a passage 22, 25 which is provided with fine perforations 23a in the middle part for the purpose of flow control and which is also provided with an infusion needle at the end. Then the device is used with the flow rate controlled by a flow rate control means 12 and also measured by a flow rate measuring means 26, with an external programming means 41 connected for a control means 19 that is connected to a storage means 16, with a dosage schedule set and transmitted, and then with the external programming device removed.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid medicine injecting device and a liquid medicine bag, which is small and lightweight for injecting a liquid medicine contained in a container into epidural, arteriovenous blood vessel, subcutaneous, muscle, various organs, etc. Since it can be used as a portable device and can be used by arbitrarily setting the liquid injection amount, the injection period, the injection time interval, etc., it is particularly preferably applied to the liquid injection pump. It is about possible technology.

[0002]

2. Description of the Related Art Conventionally, various portable liquid injectors have been proposed for continuous microinjection of narcotics containing morphine hydrochloride for the purpose of pain relief, anticancer agents for cancer treatment, antibiotics and the like. . According to these portable liquid injectors, an electric pump using a power source such as a motor with electricity as an energy source is used, such as a battery-driven small syringe pump or a peristaltic pump.

According to this electric pump, it is possible to appropriately control so as to obtain an arbitrary injection amount by using an electric circuit, a control circuit by a microprocessor or the like, and therefore, fine drug administration management according to the condition of the patient is possible. It has the characteristic of being feasible.

On the other hand, as compared with such an electric pump, a liquid medicine injection device using a balloon made of an elastic material is known as a pump which is smaller and lighter in weight, can be constructed at a low price, and is easy to operate. For example, Japanese Patent Publication 6-83725
According to Japanese Patent Laid-Open No. 6-296688 and Japanese Patent Laid-Open No. 6-296688, a pump system is proposed in which a balloon is filled with a drug solution and the contraction force of the balloon is used to inject the drug solution. Further, according to Japanese Patent Publication No. 51-117489, the bellows are compressed by utilizing the vapor pressure of a gas enclosed in a metal bellows and a case that covers the metal bellows, and a chemical solution in the bellows is discharged. A pump system has also been proposed as a liquid medicine injection device configured to perform injection. Further, according to Japanese Patent Application Laid-Open No. 7-509, after filling a chemical solution in a cylindrical container, this is stored in a capsule and a plunger (presser) is attached, and this plunger is moved by a spring type constant force spring. There is also proposed a method of discharging a chemical solution in this manner.

Further, according to Japanese Patent Publication No. 6-32656, a medical container in which a liquid medicine is stored in advance and a pressure container are housed in a common pressure chamber, and an air pump is provided for the pressure container. By externally supplying pressure from a pressurizing unit consisting of, the above-mentioned drug solution is delivered to the outside of the medical container by reducing the volume by applying pressure from the outside to the above-mentioned medical container, A device has also been proposed in which a flow channel monitoring device provided downstream of the drip tube monitors air bubble inclusion, and an automatic clamp prevents an accident when a water bubble is generated.

[0006]

However, according to the chemical liquid injection device using the electric pump as described above, fine chemical liquid injection control is possible, but on the other hand, the mechanical parts and the power source attached to the electric pump can be used for the entire device. The external dimensions are large, and the weight is large, which results in poor portability. Further, it is pointed out that most of them have a structure in which an operating portion for setting the injection of the chemical liquid is integrally provided, so that the cost becomes high and the operation becomes complicated, too.

On the other hand, according to the chemical injection device using a balloon type pump which can be constructed at a low price and a pump which utilizes gas pressure, it is possible to construct a small size and a light weight, which is advantageous in portability. However, in these chemical liquid injectors, the pressure cannot be adjusted arbitrarily, and most of them control the flow rate with a single orifice (fluid resistor with fine holes), so one model has one flow rate. The drawback is that you can only set In addition, since the flow path for injecting the drug solution cannot be turned on / off arbitrarily and automatically, only continuous micro injection is possible, so it is not possible to administer a detailed drug solution according to the patient's condition. is there.

Further, according to Japanese Patent Publication No. 6-32656, the medical solution is delivered to the outside by reducing the volume of the container containing the medical solution by externally applying pressure to the medical container. The flow channel monitoring device provided downstream of the drip tube is configured to monitor air bubble mixing, but does not detect the flow rate of the chemical liquid and uses an electric air pump as a pressurizing device. Therefore, it cannot be configured as a portable type,
In particular, it cannot be configured at all as a portable chemical injection device.

Therefore, the present invention has been made in view of the above-mentioned conventional problems, and because it is small and lightweight, it is excellent in portability and can be constructed at a low price, and moreover, it can be adapted to a patient's condition (condition, symptom). Accordingly, it is an object of the present invention to provide a drug solution injecting device and a drug solution bag in which an injecting amount of a drug solution, an injecting period, an injecting time interval, etc. can be arbitrarily set and controlled in detail.

[0010]

In order to solve the above-mentioned problems and to achieve the object, according to the chemical liquid injector of the present invention,
A chemical liquid injection device for connecting a pressurizing means with a chemical liquid cartridge having a chemical liquid bag or detachably accommodating the chemical liquid bag and injecting the chemical liquid at a predetermined flow rate, the chemical liquid injection device being provided at a discharge port of the chemical liquid bag and having a flow rate restricting portion at an intermediate portion. A flow path that has micropores for use and that is provided with an injection needle at the end or is connectable to the injection needle, and a flow rate control means that controls the flow rate of the drug solution in the flow path, Flow rate measuring means for measuring the flow rate of the chemical solution, control means connected to the flow rate controlling means and the flow rate measuring means, and provided so as to be connectable to the control means for setting an administration schedule of the chemical solution In addition, it is characterized by comprising external programming means for transmitting the administration schedule to a storage means connected to the control means.

Further, a chemical solution bag for preventing air bubbles from being mixed and being filled with the chemical solution and discharging the chemical solution from the discharge port with a decrease in volume, and the chemical solution bag are housed and pressurized through a pressure hole. A liquid medicine cartridge having a pressurizing chamber detachably connected to the means, and detachably provided to the discharge port, having fine holes for restricting a flow rate at an intermediate portion, and an end portion. A flow path having an injection needle, a flow rate control means for controlling the flow rate of the drug solution by opening and closing the flow path, a flow rate measuring means for measuring the flow rate of the drug solution, the flow rate control means and the flow rate measurement A control means connected to the means, and a storage means that is provided so as to be connectable to the control means for setting the administration schedule of the drug solution and to the storage means connected to the control means. An external programming unit for transmitting a schedule is provided, and the control unit and the pressurizing unit are integrally configured as a control unit, and the flow passage, the action portion of the flow control unit, and the flow measuring unit are detected. It is characterized in that the chemical liquid cartridge, the control unit and the flow rate control device are used by being connected to each other by forming a unit with the flow rate control device.

[0012] The chemical solution bag is filled with the chemical solution by preventing bubbles from being mixed therein, and is attached to and detached from the pressurizing means via the pressurizing means and the chemical solution bag for ejecting the chemical solution from the discharge port as the volume decreases. It is characterized in that a pressure bag that is freely connected is integrally formed through a partition wall.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

First, FIG. 1 is an external perspective view showing the overall configuration of the chemical liquid injection pump 1 shown together with the state of attachment to a patient P.

In the figure, the liquid medicine injecting pump 1 has a shape so that it can be put in a chest pocket of a patient's clothing as shown in the drawing, and the display device 15 is directed upward so that the patient P can be kept at any time. A flow control unit 11 that can be seen and is configured such that the switch 18 is located on the front side, a flow control device 21 incorporated in the unit 11, and a detachable attachment / detachment to the flow control device 21 as described later. And the external programming device 41 such as a notebook computer connected to the connector C1 provided in the flow rate control unit 11 via the interface cable 20 (for example, RS232C cable for serial interface). Has been done.

Further, the flow rate control unit 11, the flow rate control device 21, and the chemical liquid cartridge 31 are configured so as to be detachable from each other in the directions of arrows D1 and D2 in the figure, and as shown in the lower left usage state diagram. After being set so as to be integrated by, for example, snap-fitting, it does not easily come off due to the action of an external force.

Further, when integrally set as shown in the figure, while the connector C2 of the flow control device 21 is in a state of being connected to the flow control unit 11, the pressurization provided on the upper part of the chemical liquid cartridge 31 is set. The hole 34 is automatically connected to the pressure generating unit 51 provided on the flow control device 21 side, and in the connected state, the automatic valve 3
By opening 4a, the gas from the gas cylinder provided in the pressure generating part 51 is automatically supplied to the chemical liquid cartridge 31.

On the other hand, a predetermined amount of the liquid medicine M is filled in the liquid medicine bag 32 housed in the liquid medicine cartridge 31 in advance by a vacuum pack so as not to mix air bubbles, and also to prevent air bubbles from being mixed in during operation. It is configured. The chemical liquid cartridge 31 is made of a transparent or semi-transparent hard polymer material having a predetermined mechanical strength so that the consumption state of the chemical liquid can be seen from the outside. A partition wall 33, which acts as a partitioning member between the chemical liquid cartridge 31 and an inner wall of the chemical liquid cartridge 31 and which is made of an elastic body and can seal the introduced gas without leakage, is provided as will be described later.

The partition 33 is constructed such that when a gas is introduced into the partition 33 through the pressurizing hole 34, the space portion shielded by the partition 33 expands and moves to the chemical solution bag 32 side to apply pressure. , The liquid medicine bag 32 by this moving operation
The basic operating principle is to send the internal chemical liquid M to the flow rate control device 21 by contracting the inside of the cartridge.

Here, examples of the material of the chemical liquid cartridge 31 include polymer resin materials such as polycarbonate, acryl and polystyrene, which are excellent in mechanical strength and light transmission. Further, as the material of the drug solution bag 32, there is a resin material such as polyethylene, polyurethane, vinyl chloride, or polypropylene, which is excellent in flexibility and light transmittance. Further, as the material of the partition wall 33, polyethylene,
Polyurethane, polypropylene, vinyl chloride, silicone rubber, urethane rubber, fluorine rubber, isoprene rubber,
Examples of such materials include butadiene rubber and natural rubber, which are highly flexible and durable. Further, when the partition wall 33 and the cartridge 31 are integrally molded, the same kind of material is used, but the so-called two-color molding technique may be used by using different resin materials only in the partition wall.

Subsequently, referring to the block diagram of FIG. 2 in FIG. 1, first, the pressure for moving the partition 33 is applied by the pressure generating unit 51 including a gas cylinder provided in the control unit 11. The pressure in 33 is applied so as to be constant. Although an electric pump that is small and consumes less power can be used as this pressure generator, an ultra-compact gas cylinder filled with liquefied carbon dioxide that has recently been allowed to be sold to the general public for repairing flat tires. By using, it becomes possible to form a very small size.

The pressure generating unit 51 is provided with a pressure adjusting unit 52 connected to, for example, a gas cylinder, and the generated pressure is adjusted to a constant value by a pressure adjusting valve, and the pressure generating unit 51 is surrounded by a partition 33 in the chemical liquid cartridge 31. The pressure gas is introduced into the space through the pressure hole 34 that is automatically connected as described above. As the gas filled in such a gas cylinder, there are helium, nitrogen, alternative CFC gas, etc. in addition to the above carbon dioxide, and the generated pressure is 26 to 66 kPa (about 200 to about 500 mm).
It is desirable to adjust to the range of Hg). On the other hand, in the drug solution bag 32 in the drug solution cartridge 31, the connection pipe 22 provided in the flow rate control device 21 is provided with the arrow D2 as described above.
By moving in the direction, it is automatically inserted and the communication is established. The chemical solution M passing through the connecting pipe 22 passes through the fluid resistor 23 having the fine holes 23a (orifices), and the inner diameter of the fine holes 23a is preferably 10 to 500 μm, and is arbitrarily selected within the range of the target flow rate. Will be done.

The chemical solution M thus passing through the fluid resistor 23.
Is controlled to be a substantially constant flow rate by being on / off controlled by a fluid control valve 24 that has an action of opening and closing the flow path. Therefore, the fluid control valve 24 prevents the flexible tube 25, which is the flow path, from flowing. By a pressing action of the movable shaft 12a of the solenoid of the valve drive mechanism 12 which is a flow rate control valve provided in the flow rate control unit 11, the flexible tube 25 itself is directly crushed as shown in the figure to close the flow path. However, it goes without saying that other known valve mechanisms can also be used. Therefore, when the valve drive mechanism 12 is off and the fluid control valve 24 is open, the chemical liquid bag 3
The gas pressure applied to 2 and the flow path resistor 23
A constant flow rate of the medicinal solution M determined by the fluid resistance due to is injected into the patient. In addition, this valve drive mechanism 2
By controlling the flow rate in a time-division manner using 4, it is possible to obtain an arbitrary time flow rate value with the maximum time flow rate value when the flow path is opened. Therefore, flow rate control suitable for each administration mode described later can be performed. It will be possible.

On the other hand, the flow rate control device 21 is further provided with a flow rate sensor 26 for measuring the flow rate of the chemical liquid in the downstream portion of the valve mechanism 24, and is attached to and detached from the control unit 11 via the connector C2. Connected possible. That is, as shown in FIG. 1, the pump assembly is connected to the control unit 11 so as to detect the flow rate, and is connected to the CPU 19 via the flow rate sensor driver 13 and the flow rate signal amplifier 14. Has been done. The flow sensor 26 is preferably a thermal type flow meter including a heater and a thermistor, but may be a positive displacement type flow meter, a differential pressure type flow meter, an ultrasonic flow meter, an electromagnetic flow meter, or the like.
Further, the control unit 11 is connected to the CPU 19 mounted on the mounting board by the respective elements shown in the figure. Specifically, the control unit 11 is connected to the valve drive mechanism 12 via a gate array, a driver element 105, etc. The display section 15 including an 8-segment liquid crystal display element, a memory 16 including an EPROM element capable of retaining stored contents even when the power is off, and the operation switch 17 are turned on when both are pressed at the same time. Chemical solution injection switch 18a, 1 connected with an AND circuit
8b, an external interface element 101 connected to a personal computer as an external programming device 41 via a connector C1, an alarm buzzer 102, and a replaceable dry battery 103. The overall operation of the liquid medicine injection device configured as described above is controlled by using software installed in the external programming device 41, and the liquid medicine injection amount, the injection time, and the PCA (Pat) called manual injection are required.
The information necessary for the pump operation such as ient controlled anesthesia) amount is input by a doctor or a qualified person, and the information is input through the external interface 101 of the control unit 11 using the external interface of the external programming device 41. External programming device 4 at this point
1 and the control unit 11 are separated.

The control unit 11 includes the flow control device 2
By combining 1 with the chemical liquid cartridge 31, it will function as a chemical liquid injection pump. Therefore, when these are combined, when the operation switch 17 of the control unit 11 is turned on, according to the input pump operation information,
The chemical solution injection is started after the priming operation.

The flow rate control is performed by sending a signal from the CPU 19 to the valve drive mechanism 12 for flow rate control as described above. Therefore, the flow rate signal from the flow rate sensor 26 is sent to the CPU 19 through the flow rate signal amplifier 14 and monitored. This flow rate signal is fed back to the valve drive mechanism 12 based on the difference between the flow rate from the pump and the measured value to perform on / off control, thereby performing flow rate control based on each administration mode described later. I have to. Also,
The flow rate signal from the flow rate sensor 26 is also used to generate an alarm from the buzzer 102 when an abnormality such that flow rate detection cannot be executed is detected. Further, when the patient P using the drug solution infusion pump 1 is, for example, a terminal cancer patient and cannot bear severe pain by any means, the above-mentioned PC for optionally injecting a drug solution such as morphine hydrochloride
Inject switches 18a, 18b to achieve A injection
When both are simultaneously pressed, a preset amount of PCA of morphine hydrochloride is infused into the patient, and care is taken to alleviate the patient's pain. Such usage status is optionally stored in the built-in memory 19, and by connecting to the external programming device 41, the usage information can be read out, which is useful for creating the next administration schedule.
It is designed to be used as a reference for preparing the next prescription.

FIG. 3 is a flow chart showing the above-mentioned actual use state, showing a program at the time of initial setting.

In the figure, first, in step S1, a doctor or a qualified person loads or calls an administration program after the external programming device 41 such as a notebook computer is turned on. Then, in step S2, the interface cable 20 (for example, RS232C cable for serial interface) is connected to the main body of the control unit 11 via the connector C1.

Then, in step S3, a personal identification number corresponding to the patient chart is input from the device 41,
Check the medical condition and liquid medicine. When the content of the patient chart is displayed on the display screen of the device 41 in this way, the administration schedule is determined in step S4, and the type of drug solution,
Enter the injection amount, the injection period, the injection time interval, and the set value of the above-mentioned conditions for PCA injection when the drug solution is morphine hydrochloride, for example.

Since the control conditions for administration have been determined as described above, subsequently, in step S5, the power of the control unit 11 is turned on, the control condition data is transmitted and stored in the RAM 16 which is a storage unit. It Further, before and after this operation, the patient's prescription written on the drug solution cartridge 31 filled with the desired drug solution is printed out from the printing device connected to the external programming device 41. This completes the work of the doctor or qualified person. It is to be noted that the drug solution cartridge 31 for a maximum of two weeks can be prepared at the pharmacy by one prescription, so that the small gas cylinder and the flow rate control device 21 are provided accordingly.

Subsequently, in step S6, the connecting pipe 22 of the flow control device 21 is set in the liquid medicine cartridge 31 so as to penetrate the liquid medicine bag 32, and then set in the control unit 11 to set the valve mechanism 12. While it is in an operable state, the connector C2 brings it into an electrically connected state. In the case of a model that does not use an electric pump in the pressure generating unit 51 on the control unit 11 side, a small gas cylinder is set so that the generated pressure can be introduced into the chemical solution cartridge 31 via the pressurizing hole 34. Next, in step S7, the initial operation program is started based on the instruction from the external programming device 41, and the function check program, which will be described later, for checking the priming and the functions of the respective parts is started.

As described above, the operation with the external programming device 41 connected is completed, and the process proceeds to step S8 in which the interface cable 20 is removed at the connector C1 and the injection needle 25a connected to the distal end of the tube 25a is placed on the patient side in advance. The embedded cap PC is in a state of being punched. After this, in step S9, step S4
The automatic administration program is started based on the administration program set in. Further, when the drug solution is morphine hydrochloride for pain relief, the above program for PCA injection is started.

As described above, the patient can receive the medical treatment and pain relief, and the administration history of the device is stored in the storage unit 19 in step S10 during the administration for a predetermined period. In step S11, the administration is continued until the remaining amount of the liquid medicine becomes small, and when the remaining amount becomes small, the administration ends.

FIG. 4 is a flow chart showing a specific example of the administration schedule in step S4 of FIG. In this figure, in step S20, the doctor confirms the medical condition and medical history of the patient, and in step S21, selects and determines either (a) continuous administration, (b) intermittent administration, or (c) continuous / intermittent administration pattern. Then, input from the external programming device 41. Then, step S
At 22, the flow rate setting, the administration time interval (H1, H2), the dose for PCA infusion, and the refractory period for prohibiting this PCA infusion are input based on the determined administration pattern. Then, in step S23, the PCA permission period is input, and in step S24, the maximum daily dose is input.

FIG. 5 is a flowchart showing a specific example of the initial operation program in step S7 of FIG. In the figure, when both the switches 18a and 18b are pressed at the same time in step S30, this program is started, and the liquid medicine is discharged from the liquid medicine bag in the pressurized state (step S31), and the valve is opened. The solenoid of the mechanism 12 is turned off (step S3
2) In step S33, it is determined whether or not a predetermined flow rate is detected by the flow rate sensor 26, and if there is no flow rate detection, it is determined that some abnormality has occurred, and the flow proceeds to step S37 to determine an abnormality. By setting a generation flag, processing following this step is prohibited, and step S3
In step 8, the buzzer 102 is continuously energized to notify an abnormal state, and the process is forcibly ended in step S39.

On the other hand, when the predetermined flow rate is detected in step S33, the priming is completed by confirming the discharge of the liquid medicine from the injection needle 25a in step S34, and the valve mechanism is turned on in step S35 to prohibit the discharge. Then, in step S36, the administration sequence ends.

FIG. 6 shows the second and subsequent administration programs, in which the administration schedule according to the flowchart shown in FIG. 3 is changed. When it is necessary to make such a change, in step S40, the doctor or qualified person uses the external programming device 4 such as a notebook computer.
After the power is turned on, the administration program is loaded or called. Then, in step S41, the interface cable 20 is connected to the main body of the control unit 11 via the connector C1.

Subsequently, in step S42, a personal identification number that matches the patient chart is input from the device 41, and the medical condition and the medical solution are rechecked. In this way the device 4
The content of the patient chart is displayed on the first display screen.

Next, in step S43, the administration history stored in the storage unit 19 of the control unit is downloaded to the device 41 side via the interface cable 20 and displayed on the screen of the device 41. The doctor sees the activation administration schedule again to determine the optimal administration pattern, and again inputs the drug solution type, the injection amount, the injection period, and the injection time interval (step S44).

Thereafter, in step S45, the power of the control unit 11 is turned on, the transmission of the control condition data is executed, the data is stored in the RAM 16 which is the storage unit, and the chemical liquid cartridge 31 filled with the desired chemical liquid is filled in. The patient's prescription is printed out from a printing device connected to the external programming device 41. After this, the above steps S6 to S11 (step S46) are executed, and thereafter steps S40 to S46 are executed until the patient is completely cured.

Next, FIG. 7 is an operation principle diagram (a) and a waveform diagram (b) when the flow rate sensor 26 provided in the flow rate control device 21 is constituted by a thermal type flow meter. In the figure, the tube 25 has the same cross-sectional area S in the longitudinal direction, and a heater 26h is provided on the upstream side which is a flow path of the chemical liquid.
It is connected to the CPU 19 via. Further, a thermistor 26t for temperature detection is disposed downstream of the heater 26h by a distance L.

In the above configuration, the heater heating signal H as shown in FIG. 7B is applied to the chemical liquid M flowing downstream in the direction of the arrow at the required flow velocity at time t1 to energize the heater 26h. The temperature of the chemical solution is raised. In this way, the peak value of the temperature rise is detected at time t2 by the thermistor 26t which is arranged downstream of the temperature rise by the distance L and is connected to the CPU via the flow rate signal amplifier 14. The thermistor output signal T having such a waveform is obtained.

From the above, the time difference Δt = t1-t2 is obtained by the built-in timer, the distance L is divided by the obtained time difference Δt to obtain the flow velocity of the chemical liquid, and the flow velocity V obtained by multiplying this flow velocity by the cross-sectional area S is obtained. obtain. Flow rate V thus obtained
Based on the above, administration of the administration will be divided into time divisions as described above.

Finally, FIG. 8 is an external perspective view showing another example of the structure. When the description is omitted by giving the same reference numerals to the already described structures, the chemical solution M is an elastic balloon 132 in the chemical solution cartridge 131. It is filled inside. The chemical liquid cartridge 131 is made of a transparent or semi-transparent hard polymer material, and the contracted state due to the contractive force of the elastic balloon 132 itself can be seen from the outside. Examples of the material of the chemical liquid cartridge 131 include polymer materials such as polycarbonate, acryl and polystyrene. Further, examples of the material of the elastic balloon 132 include silicon rubber, natural rubber, butadiene rubber, isoprene rubber and the like.

The chemical solution M is applied with a constant pressure by the contraction force of the elastic balloon 132 and is sent to the flow rate control device 21 in the flow rate control unit 11 through the pressure hole 34. The flow rate control unit 11 can be configured by removing the pressurizing unit 51 from the control unit 11 described above, and can perform the chemical injection as described above in cooperation with the flow rate control device 21. Instead of the elastic balloon 132, it is also possible to use the vapor pressure of the gas enclosed in the metal bellows and the case that covers the metal bellows. According to the configuration described above, a mechanism for applying pressure to a flexible bag filled with a drug solution or filling a balloon having elasticity with a drug solution and utilizing the contracting force of the balloon to discharge the drug solution from these containers and inject it into a patient. have. Therefore, it is possible to realize a small-sized, lightweight and inexpensive pump as compared with the conventional electric pump. Furthermore, the flow rate of the injected chemical solution is controlled by a flow rate control unit connected to these chemical solution containers, and the flow rate control is configured by a fluid resistor having a fine hole and a flow path valve mechanism, and is programmed in advance by an external device. By operating based on the administration schedule, it becomes possible to realize drug injection at an arbitrary set amount and set time, which cannot be realized by the conventional portable balloon type pump.

Finally, FIG. 10 is a cross-sectional view of an essential part showing the structure of the chemical solution bag. In the figure, the container has a plurality of independent chambers, and each chamber is a container 131 formed by a flexible diaphragm, and the adjacent diaphragms have the same surface area. With the above configuration, it is possible to eliminate the remaining amount when the side of the chemical solution bag is contracted by supplying gas to the gas chamber (bag). Further, since it can be made compact by being integrated with a gas bag which is a pressure bag, space saving and cost reduction are possible.

In order to configure as described above, three resin sheets formed into a flat surface are stacked, a tube of an appropriate length is sandwiched between the respective sheets, and the outsides of the sheets are fused together. . At that time, each tube is fused to the sheets on both sides with its lumen secured, so that 2
A closed bag having two identical shapes and having a superposed shape is formed, and each tube serves as a unique port (inlet / outlet) in each bag (bag).

One of the thus obtained chemical solution bags is filled with the chemical solution. In this state, if a gas with a predetermined gas pressure is injected into the bag of another method, the diaphragm is pushed toward the drug solution by the gas pressure, so the same pressure is generated in the bag filled with the drug solution, and the port on the drug solution bag side Can be extracted from.

Further, since the diaphragm is pushed by the gas pressure until the diaphragm is completely adhered to the drug solution bag, the remaining amount can be made substantially zero, which is ideal.

FIG. 11 is a schematic view of the manufacturing process showing another embodiment of the chemical liquid bag. In this figure, a drug solution bag having the same two chambers as the drug solution bag described above except that the diaphragm 132 has a two-layer structure by stacking and fusing two preformed bags in the shape as shown. 1
31 can be molded.

Further, in the schematic view of the manufacturing process showing another embodiment of the liquid medicine bag, the outer sheet is made of a hard material and only the diaphragm is made of a flexible material, and the original shape is retained. By adopting a three-dimensional shape that can be formed, it becomes possible to reduce the pressure loss caused by the deformation of the drug solution bag.

As a sheet for forming the above-mentioned chemical solution bag, an olefin type (PP, PE), PET, soft vinyl chloride, and a composite material having a steam barrier and a gas barrier property are used.

As described above, according to the present invention, since it can be constructed in a small size and a light weight, it is excellent in portability, and the number of disposable parts can be minimized to reduce the cost, and the condition of the patient (mode, It is possible to provide a drug solution injecting device and a drug solution bag (injection container) capable of managing administration by finely setting an injecting amount of a drug solution, an injecting period, an injecting time interval and the like in accordance with symptom).

[0053]

[Brief description of drawings]

FIG. 1 is an external perspective view showing the overall configuration of a drug solution injection pump 1 shown together with a state of attachment to a patient P.

FIG. 2 is a block diagram showing a state after the flow rate control device 11, the control unit 21, and the chemical liquid cartridge are connected.

FIG. 3 is a flowchart of setting an administration schedule.

FIG. 4 is a flowchart showing a specific example of step S4 in FIG.

FIG. 5 is a flowchart of an initial operation.

FIG. 6 is a flow chart of second and subsequent administration schedule setting.

FIG. 7 is an explanatory diagram of flow rate measurement.

FIG. 8 is an external perspective view showing the overall configuration of the chemical liquid injection pump 1.

FIG. 9 is a cross-sectional view of a main part of a drug solution bag.

FIG. 10 is a schematic diagram showing a manufacturing process of a chemical solution bag.

[Explanation of symbols]

 11 Flow Control Unit 12 Valve Mechanism 13 Flow Sensor Driver 14 Flow Signal Amplifier 15 Display 16 Memory 17 Operation Switch 18 Chemical Injection Switch 19 CPU 20 Interface Cable 21 Flow Control Device 22 Connection Pipe 23 Fluid Resistor 24 Fluid Control Valve 25 Softness Tube 26 Flow sensor 31 Chemical cartridge 32 Chemical bag 33 Partition wall 34 Pressurizing hole 41 External programming device 51 Pressure generating part 52 Pressure adjusting part 52 Pressure adjusting part

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display location A61M 5/14 481

Claims (6)

[Claims] 1. A drug solution injector for injecting a drug solution at a predetermined flow rate by connecting a drug solution cartridge, which has a drug solution bag or is detachably accommodated, to a pressurizing means, wherein the drug solution injection device is provided at a discharge port of the drug solution bag. A flow path that has micropores for restricting the flow rate at a site and is equipped with an injection needle at the end or is connectable to the injection needle, and a flow rate that controls the flow rate of the drug solution in the flow path. Control means, flow rate measuring means for measuring the flow rate of the drug solution, control unit connected to the flow rate controlling means and the flow rate measuring means, and for setting the administration schedule of the drug solution, with respect to the unit means External programming means that is connectably provided and that sends the dosing schedule to a storage means that is connected to the unit means. Liquid injection device. 2. A chemical solution bag which prevents air bubbles from being mixed and is filled with the chemical solution, and discharges the chemical solution from a discharge port as the volume decreases, and the chemical solution bag is housed and pressed through a pressure hole. A liquid medicine cartridge having a pressurizing chamber removably connected to the means, and detachably provided to the discharge port, having fine holes for restricting a flow rate at an intermediate portion, and having an end portion. A flow path provided with an injection needle, a flow rate control means for controlling the flow rate of the drug solution by opening and closing the flow path, a flow rate measuring means for measuring the flow rate of the drug solution, the flow rate control means and the flow rate measurement A control means connected to the control means, and a storage means that is provided so as to be connectable to the control means in order to set a dosing schedule of the drug solution, and to the storage means connected to the control means. An external programming unit for transmitting a schedule is provided, and the control unit and the pressurizing unit are integrally configured as a control unit, and the flow passage, the action portion of the flow rate control unit, and the flow rate measuring unit are detected. A chemical injection device characterized in that the chemical solution cartridge, the control unit and the flow rate control device are used by being connected to each other by forming a flow rate control device integrally configured with a section. 3. The chemical liquid injector according to claim 1, wherein the control unit is provided with an operation unit for injecting a predetermined amount of chemical liquid by operating a chemical liquid injection switch. 4. The chemical injection device according to claim 1, wherein a small gas cylinder connected to a pressure adjusting unit is used as the pressurizing means. 5. The drug solution injector according to claim 1, wherein the soft bag filled with the drug solution is an elastic balloon, and the contraction force of the elastic balloon is used to discharge the drug solution. 6. A liquid medicine bag for preventing air bubbles from being mixed and filling the liquid medicine, and discharging the liquid medicine from a discharge port with a decrease in volume, and detachably connected to a pressure means via a pressure hole. A pressure-sensitive bag that is integrally formed through a partition wall.