JPH09248288A - Blood taking equipment for umbilical cord - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide blood taking equipment for umbilical cord which is possible to preserve recovered blood in a good condition without invasion of bacteria. SOLUTION: This blood taking equipment for umbilical cord consists of a connecting part 1 to umbilical cord and placenta of fetus or newborn infant, a drug vessel 2, a blood vessel 3 and a connecting pipe 5 to connect the connecting part 1 and the blood vessel 3. The drug vessel 2 is attached to the blood vessel 3, or may be attached to the connecting pipe 5.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a collection device for collecting umbilical cord / placental blood from human fetal or neonatal umbilical cord and placenta.

[0002]

Umbilical cord / placental blood collected from the umbilical cord and placenta of a human fetus or newborn is rich in hematopoietic stem cells and progenitor cells, and therefore gene therapy, bone marrow transplantation therapy, autologous blood transfusion, cultured blood. It is recognized that the drug product has a remarkable therapeutic effect. Umbilical cord / placental blood is easy to collect unlike bone marrow fluid, less likely to be infected with bacteria and viruses, and transplanted cells attack the patient's tissue compared to adult immune cells in bone marrow fluid. It has the advantage that complications such as one-versus-host disease (GVHD) are unlikely to occur.

Conventional umbilical cord / placental blood collection is performed by cutting the umbilical cord and collecting it by using uterine contraction, or by introducing a needle or insertion tube into the umbilical cord blood vessel or placenta blood vessel and using gravity to make use of the drop. It was collected in the container by dropping or by the suction force of a syringe or the like. A blood preservative solution is injected to preserve the blood in a good condition. However, the amount of blood preservative solution collected varies depending on the individual umbilical cord / placenta blood, so the amount of blood preservative solution is different for each collected blood volume. The calculated and quantified blood preservation solution had to be injected into the blood collection container, and the operation was very complicated. In addition, there is a risk that bacteria may be mixed when the blood preservation solution is injected.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and by injecting a blood preservation solution according to the amount of blood collected in a blood collecting container into the blood collecting container, It is an object of the present invention to provide an umbilical cord blood sampling instrument that can store recovered blood in a good condition without the risk of contamination.

[0005]

DISCLOSURE OF THE INVENTION The present invention is directed to a connecting portion of a human fetus or newborn to an umbilical cord or placenta, a drug container, a blood sampling container, and a communication tube connecting the connecting portion and the blood sampling container. And a cord blood collecting instrument in which the drug storage container is provided in a blood collecting container or a communication tube.

[0006] Here, it is preferable that the medicine container is a graduated cylinder, bag, or the like in which the injection amount of the medicine can be visually confirmed. Such a drug container may be directly connected to the blood collection container or may be branched from the connecting pipe. The blood preservation solution to be filled in the drug container is any one of anticoagulants, antibiotics, culture solution, etc., or a combination thereof, and only the necessary amount is required at a known ratio according to the collected blood volume. It can be injected into a blood collection container.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a plan view showing one embodiment of the present invention. FIG. 2 is a plan view showing another embodiment of the present invention.
As shown in FIGS. 1 and 2, the cord blood collecting device 1, 1 of the present invention
Reference numeral 0 denotes connection parts 2 and 20 capable of puncturing the umbilical cord or placenta, blood collection containers 3 and 30 for collecting umbilical cord / placenta blood, drug storage containers 4 and 40 prefilled with a blood preservation solution, and connection part 2 , 20 and blood collection containers 3, 30 for connecting communication tubes 5, 5
It consists of 0. The drug storage containers 4 and 40 may be attached to the blood collection container 3 as shown in FIG. 1 or may be attached to the communication pipe 50 in a branched manner as shown in FIG. FIG.
As shown in FIG. 6, the selection means 6 for selectively communicating the communication tube 50 and the blood collection container 30 with the drug container 40.
0 and 61 may be provided. Puncture the collected umbilical cord or placenta with the connection parts 2 and 20, and connect the cord / placental blood to the communication tube 5,
Blood is collected through the blood collection container 3 or 30 through 50, and a prefilled blood preservative can be injected from the drug container 4 or 40 according to the amount of the collected umbilical cord / placental blood.

Next, each part will be described in more detail with reference to FIG. The connecting portion 2 is preferably one that can be easily connected to the umbilical cord or placenta and can reliably collect umbilical cord / placental blood. A metal or resin-made blood collection needle is preferably used as such a connection portion 2. The blood collection container 3 is an airtight container, and a soft synthetic resin is desirable as a forming material. For example, soft vinyl chloride resin / ethylene-
Examples thereof include vinyl acetate copolymer, polyurethane resin, polyethylene resin, ethylene-α-olefin copolymer, polyfluorocarbon and polyimide. The communication tube 5 that connects the connection part 2 and the blood collection container 3 is preferably formed of a synthetic resin having a certain degree of transparency and flexibility, and for example, vinyl chloride resin, silicone rubber, polyurethane resin, polyethylene. Resin / ethylene-vinyl acetate copolymer, ethylene-α-olefin copolymer and the like can be mentioned. The drug container 4 may be a container that is hermetically sealed and has a certain degree of transparency so that a required amount of drug solution can be injected into the blood sampling container 3. As such a material, a cylinder or bag with a graduated scale is used so that the amount of the chemical liquid injected can be visually recognized. Resin etc. are mentioned. CP is used as the anticoagulant to be filled in the medicine container 4.
Liquid D, ACD liquid, EDTA liquid, heparin, etc. are adopted. RPMI1640 medium or AIM
-V or the like is adopted. As the antibiotic, penicillin, streptomycin, etc. are adopted.

Next, the embodiment shown in FIG. 2 will be described.
In this umbilical cord blood sampling instrument 10, the drug container 40 has a communication tube 5
It is the same as the first embodiment except that it is provided at one end branched from 0 and the medicine container 40 is a bag. Connection part 2
0, the blood collection container 30, and the drug container 40 are provided with selecting means 60, 61 at the communication tube 50 and its branch so as to selectively communicate with each other. Such selection means 6
Examples of 0 and 61 include a clamp, a check valve, a bent rod, and a stopcock.

[0010]

EFFECTS OF THE INVENTION According to the present invention, a blood preservation solution according to the amount of collected umbilical cord / placental blood can be quantitatively injected by a simple operation, so that the recovery work can be performed efficiently in a short time. In addition, since the cord / placental blood can be collected and stored by the closed system, there is no risk of bacterial contamination.

[Brief description of drawings]

FIG. 1 is a plan view showing an example of a cord blood collecting instrument adopted in the present invention.

FIG. 2 is a plan view showing another example of an umbilical cord blood sampling instrument adopted in the present invention.

[Explanation of symbols]

 1, 10 Umbilical cord blood sampling device 2, 20 Connection part 3, 30 Blood sampling container 4, 40 Drug storage container 5, 50 Communication tube 60, 61 Selection means

Claims (2)

[Claims] 1. A human fetus or neonatal umbilical cord or placenta connection part, a drug container, a blood collection container, and a communication tube connecting the connection part and the blood collection container,
An umbilical cord blood sampling instrument in which the drug container is provided in a blood sampling container or a communication tube. 2. The umbilical cord blood sampling instrument according to claim 1, wherein the medicine container is provided with a scale so that the injection amount of the medicine can be visually confirmed.