JPH09207959A - Container charged with liquid medicine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a unit dose type container charged with a liquid medicine, in which it can be completely capped again even when the welded part of the cap and the bottle mouth is broken and unsealed and addition of an anticorrosive agent is not required to prevent the pollution of the medicine or the secondary pollution. SOLUTION: A synthetic resin cap 2 is welded to seal a synthetic resin bottle body 1 with the bottle mouth 10. The bottle is opened by breaking the welded part 40 of the bottle body 1 and the cap 2. A reclosable means 3 hermetically sealing the bottle mouth 10 again when the mouth is covered with the cap 2 is formed at one of the bottle mouth 10 and the cap 2 or both of them. It is preferable that antibacterial zeolite is dispersed on a requied part or the whole part of the container to retain it.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention generally relates to a liquid agent filling container. More specifically, it is a synthetic resin bottle-shaped container filled with a liquid agent (including a viscous liquid agent) such as eye drops and other liquid medicines and health drinks, in which the cap is fusion-sealed at the mouth of the bottle, When using, by twisting or pressing the cap toward the bottle-shaped body,
The present invention relates to a so-called unit dose type liquid agent filling container which is used by breaking and opening the fused portion.

[0002]

2. Description of the Related Art A container filled with a liquid agent of this type is generally used as a disposable container for eye drops containing a small amount (usually one to several times) of eye drops. This type of container uses a synthetic resin compatible with the container to extrude a cylindrical parison, cut the parison, and form a bottle-shaped body by blow molding. It is manufactured by pouring and filling, and then molding the cap, and at the same time, fusing the cap to the mouth portion of the bottle-shaped body. Therefore, molding, filling, and capping and sealing are performed continuously, which is suitable for mass production, and is favorably used as the above-mentioned disposable container.

[0003]

However, the conventional unit dose type container has the following problems in the liquid agent filling container. First, it is difficult to cap the fusion-bonded portion of the cap once again after breaking and opening the cap, and even if the cap is re-capped, the cap easily comes off the bottle mouth portion.

Secondly, once opened, the liquid solution inside is easily contaminated by various bacteria, and when the filled liquid solution is used or drunk several times, it is necessary to prevent secondary contamination, and the liquid solution is preservative in advance. Must be blended. However, when the solution is an eye drop, for example, the use of the preservative is limited depending on the type of the solution to be filled in the container so that the preservative compounded may irritate the ocular mucosa. Further, since the antiseptic is easily adsorbed to the contact lens, a regular user of the contact lens cannot use the eye drop containing the antiseptic.

An object of the present invention is to provide a liquid agent filling container which can be capped again even after the fused portion between the cap and the bottle-shaped body is broken and the container is opened, which is convenient for multiple uses. To provide. Another object of the present invention is to provide a liquid agent filling container capable of preventing contamination or secondary contamination of the liquid agent after opening even if an antiseptic agent is not added to the liquid agent.

[0006]

In order to solve the above-mentioned problems, the liquid agent filling container according to the present invention has a synthetic resin cap 2 for a synthetic resin bottle-shaped main body 1 having a bottle mouth portion 10.
In the liquid agent filling container, which is fusion-sealed and is configured to be broken and opened at the fusion-bonded portion 40 between the bottle-shaped body 1 and the cap 2, the liquid-agent filled containers are configured as follows. That is, the liquid agent filling container according to claim 1 is a bottle mouth portion 10 of the bottle-shaped body 1 and a body portion of the cap 2 (a portion that covers an opening edge of the bottle mouth portion 10 before being first opened). One or both of the above are characterized in that the bottle mouth portion 10 has a resealing means 3 that is resealed by the cap 2.

A liquid agent filling container according to a second aspect is the liquid agent filling container according to the first aspect, wherein the cap 2 and the bottle mouth portion 1 are provided.
No. 0 is characterized in that when the cap 2 is resealed, the locking means 4 is lightly locked in the resealed state with respect to the pulling direction.

The liquid medicine filling container according to a third aspect is the liquid medicine filling container according to the first or second aspect, wherein when the resealing means 3 presses the cap 2 after opening to cover the bottle mouth portion 10. The small-diameter portion 21 is formed inside the cap 2 so as to be in close contact with the outer peripheral surface of the bottle mouth portion 10.

A liquid medicine filling container according to a fourth aspect is the liquid medicine filling container according to the first or second aspect, wherein when the resealing means 3 presses the opened cap 2 onto the bottle mouth portion 10, It is characterized in that it is a conical taper inner peripheral surface 23 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the upper outer peripheral portion of the bottle mouth portion 10.

A liquid medicine filling container according to a fifth aspect is the liquid medicine filling container according to the first or second aspect, in which the resealing means 3 is formed on the outer peripheral portion of the upper portion of the bottle mouth portion 10 and has a conical tapered surface 12. And a taper inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the taper surface 12 when the cap 2 after opening is pressed against the bottle mouth portion 10. It is characterized by being.

A liquid medicine filling container according to a sixth aspect is the liquid medicine filling container according to the first aspect, wherein the resealing means 3 is a male screw 13 formed on the outer peripheral surface of the bottle mouth portion 10, and the male screw 13.
And a female screw 25 formed on the inner peripheral surface of the cap 2 in a state of conforming to.

A liquid medicine filling container according to a seventh aspect is the liquid medicine filling container according to the first or second aspect, wherein when the resealing means 3 presses the cap 2 after opening so as to cover the bottle mouth portion 10, The inner plug 26 is formed on the inner upper surface of the cap 2 so as to be in close contact with at least the upper inner peripheral portion of the bottle mouth portion 10.

The liquid medicine filling container according to claim 8 is the liquid medicine filling container according to claim 1 or 2, wherein when the resealing means 3 presses the cap 2 after opening so as to cover the bottle mouth portion 10, It is characterized in that it is a ring-shaped convex portion 27 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the outer peripheral surface of the bottle mouth portion 10.

A liquid medicine filling container according to a ninth aspect is the liquid medicine filling container according to the first or second aspect, wherein when the resealing means 3 presses the cap 2 after opening so as to cover the bottle mouth portion 10, It is characterized in that it is a ring-shaped convex portion 17 formed on the outer peripheral surface of the bottle mouth portion 10 so as to be in close contact with the inner peripheral surface of the cap 2.

A liquid medicine filling container according to a tenth aspect is the liquid medicine filling container according to the first or second aspect, wherein when the resealing means 3 presses the cap 2 after opening so as to cover the bottle mouth portion 10, It is characterized in that the bottle neck portion 18 is formed on the base portion of the bottle mouth portion 10 so as to be in close contact with the inner peripheral surface of the skirt portion of the cap 2 and has an outer diameter larger than the outer diameter of the bottle mouth portion 10.

The liquid medicine filling container according to claim 11 is the liquid medicine filling container according to claim 1 or 2, wherein when the resealing means 3 presses the cap 2 after opening so as to cover the bottle mouth portion 10, It is characterized in that it is a tapered outer peripheral surface 15a of the bottle shoulder portion 15 which is continuously formed on the base portion of the bottle mouth portion 10 in a state of being in close contact with the inner peripheral surface of the skirt portion of the cap 2.

A liquid medicine filling container according to a twelfth aspect is the liquid medicine filling container according to the first aspect, wherein the resealing means 3 is a flange 19 formed on an outer periphery of an upper portion of the bottle mouth portion 10, and the cap 2 after opening. And an inward flange 29 formed on the inner peripheral surface of the skirt portion of the cap 2 so as to be tightly locked to the lower portion of the flange 19 when the bottle is pressed against the bottle mouth 10. It is characterized by being.

The liquid agent filling container according to claim 13 is the container according to claim 3,
In the liquid agent filling container of any one of 4, 5, 6, 8 to 12, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the bottle mouth is pressed against the inner upper surface of the cap 2. The small and medium plug 28 is formed in a state of closing the opening edge 10a of the portion 10.

According to the liquid agent filling container of claim 14, a plate-shaped holding piece 14 is formed at the bottom of the bottle-shaped body 1 along the length direction of the bottle-shaped body 1, and the holding piece 14 is formed. A cap-shaped resealing means 5 is provided in a part of
When the re-sealing means 5 is put on the bottle mouth portion 10 after opening, at least a part of the inner peripheral surface is in close contact with the outer peripheral surface of the bottle mouth portion 10. It is characterized in that it is configured to.

According to the liquid medicine filling container of the fifteenth aspect, a plate-shaped holding piece 14 is formed at the bottom of the bottle-shaped body 1 along the length direction of the bottle-shaped body 1, and the holding piece 14 is formed. A plug-like resealing means 5a is formed in a part of the container via a thin fusion-bonding part 51, and when the resealing means 5a is pushed into the bottle mouth portion 10 after opening. In addition, at least a part of the outer peripheral surface is configured to be in close contact with the inner peripheral surface of the bottle mouth portion 10.

According to the liquid agent filling container of the sixteenth aspect, a cap-shaped re-sealing means 5 is formed on the upper portion of the cap 2, and the re-sealing means 5 is opened after the re-sealing means 5 is opened.
When the bottle mouth portion 10 is covered with, at least a part of the inner peripheral surface is in close contact with the outer peripheral surface of the bottle mouth portion 10.

According to the liquid agent filling container of the seventeenth aspect, the cap-like re-sealing means 5a is formed on the upper part of the cap 2, and the re-sealing means 5a is opened after the re-sealing means 5a.
It is characterized in that, when a is pushed into the bottle mouth portion 10, at least a part of the outer peripheral surface is in close contact with the inner peripheral surface of the bottle mouth portion 10.

According to the liquid medicine filling container of claim 18, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and a cap-shaped resealing means 5b is formed on the upper portion of the cap 2. The resealing means 5b has an inward flange 54 on the inner peripheral portion so that the flange 19a is locked in a retaining manner when the resealing means 5b is put on the bottle mouth portion 10 after opening. In addition, the inner upper surface 55 is configured to be in close contact with the opening edge 10a of the bottle mouth portion 10.

According to the liquid medicine filling container of claim 19, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the upper end portion of the bottle mouth portion 10 is inserted into the upper portion of the cap 2. A cap-shaped resealing means 5c having a groove portion 57 of a size to be obtained is formed, and the groove portion 57 prevents the flange 19a from coming off when the upper end portion of the bottle mouth portion 10 is inserted into the groove portion 57 after opening. It is characterized in that it has an inward flange 54 that is locked in a circular shape at the inner peripheral portion, and that the inner upper surface 58 is in close contact with the opening edge 10a of the bottle mouth portion 10.

According to the liquid-filled container of claim 20, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the bottom portion of the bottle-shaped main body 1 extends in the longitudinal direction of the bottle-shaped main body 1. A plate-shaped holding piece 14 is formed along the
4, a cap-shaped re-sealing means 5b is formed via a thin fusion-bonding portion 51, and the re-sealing means 5b covers the bottle mouth portion 10 with the re-sealing means 5b after opening. In addition, the flange 19a is provided with an inwardly facing flange 54 on which the flange 19a is locked so as not to come off, and the inner upper surface 55 is in close contact with the opening edge 10a of the bottle mouth portion 10. Is characterized by.

According to the liquid medicine filling container of claim 21, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the bottom portion of the bottle-shaped main body 1 extends in the longitudinal direction of the bottle-shaped main body 1. A plate-shaped holding piece 14 is formed along the
4, a cap-shaped resealing means 5c having a groove portion 57 having a size into which the upper end portion of the bottle mouth portion 10 can be inserted is formed through a thin fusion-bonding portion 51, and the groove portion 57 is
When the upper end portion of the bottle mouth portion 10 is inserted into the groove portion 57 after opening, the flange 19a has an inward flange 54 that is locked in a retaining shape on the inner peripheral portion,
It is characterized in that the inner upper surface 58 is configured to be in close contact with the opening edge 10a of the bottle mouth portion 10.

The liquid agent filling container according to claim 22 is the container according to claim 1
The liquid medicine filling container according to any one of 21 is characterized in that the antibacterial zeolite is dispersed and held on the entire surface or a required portion.

The antibacterial zeolite is a synthetic zeolite, a natural zeolite or a mixture thereof, which contains ion exchangeable ions (eg sodium ion, calcium ion, potassium ion, magnesium ion and iron ion) such as silver, copper, It is substituted with zinc or other metal ions having antibacterial properties. As these metal ions having antibacterial properties, silver ions are preferably selected from the viewpoint of safety.

For the above-mentioned antibacterial zeolite, for example, a mixed aqueous solution of salts containing antibacterial metal ions is adjusted to a pH of about 5 to 7, and the zeolite is brought into contact with this aqueous solution at a required temperature for a predetermined period of time to obtain zeolite pores. It can be industrially obtained by substituting the above-mentioned ion-exchangeable ions contained therein with the above-mentioned metal ions having antibacterial properties. The bottle-shaped container in which the antibacterial zeolite is dispersed and held is manufactured by extruding a heat-melted resin in which powdered, granular or slurry antibacterial zeolite is mixed and kneaded into a cylindrical shape of a predetermined size to produce a parison. It can be produced by blow molding into a bottle shape by cutting it into a predetermined length.

Since this type of container is often thin, the zeolite has an average particle size of 6 μm or less and a maximum particle size of 1
It is preferably 0 μm or less. When the container is formed to have a relatively thick wall, it is preferable to disperse and hold the antibacterial zeolite only on the inner surface of the bottle-shaped body 1 and other necessary surfaces in consideration of economy. The liquid agent-filled container according to the twenty-second aspect has an antibacterial action, but its antibacterial activity naturally depends on the distribution density of the antibacterial metal ions. The necessary and sufficient mixing ratio of the antibacterial zeolite for sufficiently exhibiting the antibacterial activity varies depending on the liquid agent to be filled and other conditions, but for Escherichia coli, Staphylococcus aureus and other general bacteria and fungi existing in normal living environment. For the purpose of sterilization, an antibacterial zeolite containing an antibacterial metal in an ion concentration of 0.3 to 15 wt% is added to a synthetic resin which is a material for the bottle-shaped body.
The purpose can be achieved by mixing 1 to 7 wt%. In particular, when the liquid agent is an eye drop having almost no viscosity, 2 to 4 w of antibacterial zeolite containing 2.5 to 5 wt% of an antibacterial metal at an ion concentration with respect to the synthetic resin is used.
It is preferable to mix t%.

A liquid agent filling container according to a twenty-third aspect of the present invention is the container according to the first to third aspects.
The liquid agent filling container according to any one of No. 22 and 22, is characterized in that the container is an eye drop filling container.

In the liquid-filled container according to the present invention, the synthetic resin as the material of the container is appropriately selected depending on the type of liquid and other conditions. The steps of molding, filling, and cap fusion bonding of the liquid agent filling container according to the present invention are almost the same as those of the conventional container of this type, but the cap 2 is separately molded depending on the specific structure of the resealing means. The cap 2 is capped and fused onto the bottle-shaped main body 1 after being filled with the liquid agent.

[0033]

BEST MODE FOR CARRYING OUT THE INVENTION Preferred embodiments of a liquid agent filling container according to the present invention will be described in detail below with reference to the drawings. First Embodiment FIGS. 1 to 3 show an embodiment corresponding to claims 1 to 3, 22 and 23. The bottle-shaped main body 1 made of a relatively soft and transparent synthetic resin (for example, polyethylene) filled with the liquid medicine a that is an eye drop has a hollow plate-shaped holding piece 1 at the bottom.
4 and the bottle mouth portion 10 are integrally formed on the upper portion via the shoulder portion 15. A hollow knob portion 20 is integrally formed on the upper portion of a cap 2 made of the same material as the bottle-shaped body 1. The inner circumference of the hem portion of the cap 2 is a bottle mouth portion 10 (for example, an inner diameter of 1.5 to 2 mm). Is fused to the outer periphery of the upper end of the. In the inner peripheral inner portion of the main body portion of the cap 2 (the portion that covers the opening edge 10a of the bottle mouth portion 10 when the inner periphery of the hem portion of the cap 2 is fused to the bottle mouth portion 10), It is slightly smaller than the outer diameter of the bottle mouth portion 10 and the bottle mouth portion 1
0 so that it can be press-fitted to the outer peripheral portion of
Re-sealing means 3 is formed. An antibacterial zeolite (not shown) is dispersed and held on the entire surfaces of the bottle-shaped body 1 and the cap 2.

According to the container for filling eye drops of this embodiment, when the user holds the holding piece 14 with one hand, the other hand holds the knob 20 of the cap 2 to hold the cap 2 on the bottle mouth 10. By twisting in a direction, the fused portion 40 is broken and the bottle-shaped body 1 is opened. The container is used in such a manner that after opening the container in this manner, the bottle-shaped main body 1 is tilted upside down to bring the bottle mouth portion 10 close to the eye, and the main body 1 is pinched to push out the liquid agent a therein.

The filling container of this embodiment includes a bottle mouth portion 10
On the outer peripheral part of the convex portion 11 is formed so as to be continuous or interrupted in the circumferential direction below the fusion-bonding portion 40, and on the other hand, when the fusion-bonding portion 40 is broken as described above, the cap is formed. A rupture mark remains on the inner circumference of the skirt portion of No. 2, and a convex portion 22 continuous to the rupture mark in the circumferential direction is formed as shown in FIG. When the cap 2 is resealed, the convex portion 22 and the convex portion 11 constitute a locking unit 4 that is lightly locked in the resealing state in the pulling direction.

This liquid-filled container is used for molding the bottle-shaped main body 1,
The filling and capping of the liquid agent a are performed in the following series of lines. In the following description, neither the manufacturing equipment nor the molded product in the manufacturing process is shown. First, an antibacterial metal (silver ion in this example) is added to the heat-melted polyethylene at an ion concentration of 2.5 to 5
The antibacterial zeolite containing wt% is kneaded in a ratio of 2 to 4 wt% and extruded by an extruder between two sets of blow mold dies to manufacture a tubular parison of a predetermined size. When the parison is extruded for a predetermined length, the main body molding dies of the mold set are united to fuse and seal the lower end of the parison, and the parison is cut at a predetermined length position. Next, the mold set is moved to another place, compressed air filtered by a nozzle is supplied to the inside of the parison, and the parison is expanded toward the inner wall side of the surrounding main body molding mold, and the bottle mouth 10 The bottle-shaped body 1 except for is molded. After the bottle-shaped main body 1 is molded, the liquid agent a is charged into the inside of the bottle-shaped main body 1 by, for example, 0.
About 6 to 1.8 ml is filled, the mold set is moved to another place, and the other mold set above the main body molding mold is combined to mold the bottle mouth 10. While the bottle mouth portion 10 is in a heated state, the separately molded cap 2 is covered on the bottle mouth portion 10 and the hem portion is fused to a required portion on the outer periphery of the bottle mouth portion 10, and then the whole is cooled. Let

Through the above manufacturing steps, the antibacterial zeolite is dispersed and held on the entire surface, the re-sealing means 3 (small diameter portion 22) and the locking means 4 as described above are provided, and the inside thereof is filled with the eye drops. Bottle-shaped containers are manufactured. Although a single container is shown in this embodiment, it is usually manufactured integrally as a plurality of bottle-shaped bodies 1 arranged side by side through a thin connecting portion 16 on the side of the bottle-shaped body 1. It is configured to be separated one by one from the connecting portion 16 at the time of use.

According to the liquid agent filling container of this embodiment, even if the fusion bonding portion 40 between the cap 2 and the bottle mouth portion 10 is broken as described above and the bottle mouth portion 10 is opened, the cap 2 is opened. Part 1
When it is pressed against the bottle mouth portion 10 in such a manner that it is covered with 0, the bottle mouth portion 1 is inserted into the small diameter portion 21 of the cap 2 constituting the resealing means 3.
The upper part of 0 is lightly pressed in. by this,
As shown in FIG. 3, the small-diameter portion 21 adheres to the outer peripheral surface of the upper portion of the bottle mouth portion 10 to recap the bottle mouth portion 10 in a hermetically closed state, and at the same time, the cap 2 which is a trace of breakage of the fusion-bonded portion 40. The convex portion 22 rides over the convex portion 11 formed on the bottle mouth portion 10, and the cap 2 and the bottle mouth portion 10 are locked so as not to come off. Therefore, the cap 2 does not come off from the bottle mouth portion 10 during normal storage and handling. When the cap 2 is pulled from the bottle mouth portion 10 along the direction of pulling out to some extent strongly, the convex portion 22 rides over the other convex portion 11 and comes off, and the bottle mouth portion 10 comes out of the cap 2. Reopened.

Test Example-1 First, according to the following formulation, an eye drop was prepared by a conventional method. Next, to the heat-melted polyethylene, 0 wt%, 2 wt% and 3 wt% of antibacterial zeolite powder having an average particle size of 6 μm and containing 2.5% of silver in an ion concentration were added and kneaded uniformly, and these polyethylenes were mixed. Use,
Each sample having the same configuration as the container of the first embodiment filled with 1.0 ml of the eye drop prepared as described above was manufactured.
These specimens were opened, the required bacteria were inoculated into the eye drops filled therein, and the antibacterial activity test was conducted according to the USP. The results are shown in Table-1, and each sample with the antibacterial zeolite dispersed and held,
It could be confirmed that it had a sufficient antibacterial activity.

[0040]

[Table 1]

Test Example 2 3 wt% of an antibacterial zeolite powder containing 2.5% of silver at an ion concentration and having an average particle size of 6 μm was uniformly kneaded into polyethylene which was heated and melted, and this polyethylene was used to A sample of an empty container having the same structure as the container of the embodiment and not filled with the liquid agent was molded. The safety of these containers was evaluated in accordance with “Standards and Test Methods for Plastic Containers for Eye Drops” of Ministry of Health, Labor and Welfare Notification No. 958. The test method was to inject a finely chopped strip into a saline solution and cottonseed oil at 70 ° C. for 24 hours, and extract the saline solution into the vein of the mouse.
The extract obtained from cottonseed oil was intraperitoneally administered to male mice once, and the general condition of these mice was observed and the body weight was measured over time. Further, the same test was performed for each blank test solution (contracted saline solution itself and cottonseed oil itself). As a result, as shown in FIG. 40, no decrease in the body weight of the mouse over time was observed, and no change was observed in the general condition observation. Furthermore, to each of 3 rabbits, 0.2 ml of each of the above-mentioned container strip extracts was administered to the right eye and each blank test solution was administered to the left eye once, and the eye irritation was evaluated by the Draize method. The results are shown in Table 2, and no eye irritation was observed in any of the extracts.
It was confirmed that the safety of the empty container sample was high.

[0042]

[Table 2]

As described above, the liquid agent filling container of the first embodiment is highly safe, and since the zeolite carrying antibacterial metal ions is dispersed and held on the entire surface, the liquid agent a filled in the container is Sterilized by antibacterial metal ions in the zeolite. The peripheral portion of the opening 10a of the bottle mouth 10 which is easily contaminated by miscellaneous bacteria during use is also always sterilized. Therefore, it is not necessary to add a preservative to the liquid agent a in order to prevent contamination by secondary bacteria and secondary contamination. Further, the liquid agent filling container of the first embodiment is very convenient for carrying it and repeatedly using the filled liquid agent a in several times. The filling amount of the liquid medicine a which is an eye drop is 2
Corresponding to the usage amount of about 6 times, regular users of eye drops do not need to carry a large-capacity bottle-shaped container, and compared to conventional unit-dose type containers that are used once and discarded.
Cheaper and more economical.

Second Embodiment FIG. 4 and FIG. 5 show an embodiment corresponding to the liquid agent filling container of claim 4. In this embodiment, another mode of the resealing means 3 is shown, and the resealing means 3 is constituted by a conical tapered inner peripheral surface 23 formed on the inner peripheral portion of the cap 2. According to the container of this embodiment, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the tapered inner peripheral surface 23 strongly adheres to the upper outer periphery of the bottle mouth portion 10 as shown in FIG. At the same time, the locking means 4 composed of the convex portion 11 on the outer peripheral portion of the bottle mouth portion 10 and the convex portion 22 on the inner peripheral portion of the skirt portion of the cap 2 is lightly locked in a retaining shape. Other configurations, operations, and effects in this embodiment are almost the same as those of the liquid agent filling container of the first embodiment, and therefore their description is omitted.

Third Embodiment FIG. 6 and FIG. 7 show an embodiment corresponding to the liquid agent filling container of claim 5. In this embodiment, yet another aspect of the resealing means 3 is shown.
Is formed by a conical tapered inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 and a conical tapered surface 12 formed on the outer peripheral portion of the bottle mouth 10. According to the container of this embodiment, when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening, the tapered inner peripheral surface 24 becomes the tapered surface 1 of the bottle mouth portion 10 as shown in FIG. 7.
While sticking to the state of being pressed against 2, the bottle mouth part 1
No. 0 outer ridge 11 and cap 2 hem inner ridge 2
The locking means 4 composed of 2 and 3 is lightly locked in a retaining shape. Other configurations, actions, and effects of the container of this embodiment are almost the same as those of the liquid agent filling container of the first embodiment, and therefore their explanations are omitted.

Fourth Embodiment FIG. 8 shows an embodiment corresponding to the liquid agent filling container of claim 6. In this embodiment, another mode of the resealing means 3 is shown. The resealing means 3 is adapted to the male screw 13 formed on the outer peripheral portion of the bottle mouth portion 10 and the male screw 13. And a female screw 25 formed on the inner peripheral portion of the cap 2. According to the container of this embodiment, when the cap 2 after opening is screwed in the tightening direction while covering the bottle mouth portion 10, the upper end portion of the bottle mouth portion 10 and the inner top surface of the cap 2 are pressed. At the same time, the cap 2 is capped in a hermetically sealed state and at the same time, the cap 2 does not come off from the bottle mouth 10. Other configurations, operations, and effects of the container of this embodiment are substantially the same as those of the container of the first embodiment, and therefore their description is omitted.

Fifth Embodiment FIG. 9 shows an embodiment corresponding to the liquid agent filling container of claim 7. In this embodiment, another mode of the resealing means 3 is shown, and the resealing means 3 is constituted by an inner plug 26 formed at the center of the inner upper portion of the cap 2. According to the container of this embodiment, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the inner plug 26 is pressed against the inner edge of the opening 10a and adheres to the bottle mouth portion 10 again. While in the hermetically closed state, the locking means 4 consisting of the convex portion 11 on the outer peripheral portion of the bottle mouth portion 10 and the convex portion 22 on the inner peripheral portion of the skirt portion of the cap 2 is lightly locked in a retaining manner. Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the container of the first embodiment, and therefore their explanations are omitted.

Sixth Embodiment FIGS. 10 to 14 show an embodiment corresponding to the liquid agent filling container according to claims 8 and 13. In this embodiment, yet another aspect of the resealing means 3 is shown. The resealing means 3 is composed of a ring-shaped convex portion 27 formed on the inner peripheral portion of the cap 2, and as a supplementary resealing means, a small / medium-sized plug 28 is provided on the inner upper surface of the cap 2. Has been formed. According to the container of this embodiment,
As shown in FIG. 12, when the cap 2 after opening is pressed to cover the bottle mouth portion 10, the ring-shaped convex portion 27 adheres to the outer peripheral surface of the bottle mouth portion 10 in a pressed state, and the bottle mouth portion 10 is Resealed. At this time, the small and medium plug 28 is pressed against the inner edge of the opening 10a, so that the bottle mouth 10 is more completely sealed. Further, the cap 2 cannot be removed from the bottle mouth 10 unless it is pulled out with a certain amount of force. FIG.
The ring-shaped convex portion 27 shown in FIGS.
Since the wall thickness is formed to be recessed inward as a whole and is pressed against the outer periphery of the bottle mouth portion 10 by the soft elasticity during the recapping, a more preferable resealed state can be obtained. In the container of this embodiment, the convex portion 27 has the cap 2 as shown in FIGS. 13 and 14.
It can be carried out even in the shape in which only the inner wall surface of the above is projected in the inner circumferential direction, or it can be carried out even if a plurality of them are formed. Other configurations and operations of the container of this embodiment
Since the effects are almost the same as those of the container in the first embodiment, their explanations are omitted.

Seventh Embodiment FIGS. 15 and 16 show an embodiment corresponding to the liquid agent filling container of claim 9. In this embodiment, yet another mode of the resealing means 3 is shown, and the resealing means 3 is constituted by a ring-shaped convex portion 17 formed on the outer peripheral portion of the bottle mouth portion 10, Further, a small-medium-sized plug 28 is formed on the inner upper surface of the cap 2 as an auxiliary resealing means. According to the container of this embodiment, FIG.
When the cap 2 after opening is pressed so as to cover the bottle mouth portion 10 as described above, the ring-shaped convex portion 17 formed on the outer periphery of the bottle mouth portion 10 adheres to the inner peripheral surface of the cap 2 in a compressed state. Therefore, the bottle mouth 10 is in a resealed state. The ring-shaped convex portion 17 is formed such that the wall thickness of the bottle mouth portion 10 bulges toward the outside as a whole, and is pressed against the outer periphery of the bottle mouth portion 10 by soft elasticity during the recapping. Therefore, a more preferable resealed state can be obtained. In the container of this embodiment, the convex portion 17 is the bottle mouth portion 10.
It can be carried out even in the shape in which only the outer wall surface of the above is projected in the outer peripheral direction, or can be carried out even if a plurality of them are formed. Other configurations and operations of the container of this embodiment
Since the effects are almost the same as those of the container in the sixth embodiment, their description will be omitted.

Eighth Embodiment FIG. 17 and FIG. 18 show an embodiment corresponding to the liquid agent filling container of claim 10. In this embodiment, yet another mode of the resealing means 3 is shown, which is formed on the base of the bottle mouth portion 10 and has a size larger than the outer diameter of the bottle mouth portion 10 and the cap 2. The bottle neck portion 18 has an outer diameter slightly larger than the inner diameter of the bottle. According to the container of this embodiment, as shown in FIG. 18, when the cap 2 after opening is pressed to cover the bottle mouth portion 10, the outer peripheral surface of the bottle neck portion 18 formed at the base portion of the bottle mouth portion 10 is Since the cap 2 comes into close contact with the inner peripheral surface of the bottom of the cap 2 in a compressed state, the bottle mouth 10 is in a resealed state. Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the container of the sixth embodiment, and therefore their explanations are omitted.

Ninth Embodiment FIGS. 19 and 20 show an embodiment corresponding to the liquid agent filling container of claim 11. In this embodiment, still another mode of the re-sealing means 3 is shown, and the re-sealing means 3 of the cap 2 is pushed when the cap 2 after opening is pressed to cover the bottle mouth portion 10. It is constituted by a tapered outer peripheral surface 15a of the bottle shoulder portion 15 which is continuously formed on the base portion of the bottle mouth portion 10 so as to be in close contact with the inner peripheral surface of the hem portion. According to the container of this embodiment, FIG.
As described above, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the inner peripheral surface of the hem portion of the cap 2 is brought into close contact with the tapered outer peripheral surface 15a of the bottle shoulder portion 15 in a compressed state. The mouth 10 is resealed. Other configurations, operations, and effects of the container of this embodiment are almost the same as those of the container of the sixth embodiment, and therefore their explanations are omitted.

Tenth Embodiment FIGS. 21 and 22 show an embodiment corresponding to the liquid agent filling container of claim 12. In this embodiment, another mode of the resealing means 3 is shown. The resealing means 3 is formed on the flange 19 formed on the upper outer periphery of the bottle mouth portion 10 and on the inner peripheral surface of the skirt portion of the cap 2. And an inwardly facing flange 29 that is formed. The inward flange 29 is formed so as to incline slightly upward in the cross section, and the fusion bonding portion 40 between the cap 2 and the bottle mouth portion 10 is formed.
Is formed at the interface between the tip of the inward flange 29 and the lower surface of the flange 19. According to the container of this embodiment, when the cap 2 is pushed toward the bottle mouth 10 and twisted, the fusion-bonded portion 40 is broken, and the cap 2 is closed.
When pulled in a direction away from, the inward flange 29 gets over the flange 19, so that the bottle-shaped main body 1 is opened. Then, the cap 2 after opening is attached to the bottle mouth portion 10
When it is pressed so as to cover it, the inward flange 29 gets over the flange 19 and is tightly locked to the lower portion of the flange 19, so that the bottle mouth portion 10 is resealed. Other configurations, operations and effects of the container in this embodiment are
Since the container is almost the same as that of the first embodiment, the description thereof is omitted.

In FIG. 23 and below, the resealing means is the cap 2
An embodiment provided in a portion other than the main body and the bottle mouth portion 10 is shown. Eleventh Embodiment FIGS. 23 to 26 show an embodiment corresponding to the liquid agent filling container of claim 14. In this embodiment, a cap-shaped resealing means 5 having a ring-shaped convex portion 50 on the inner peripheral surface is provided in a part of the hollow plate-shaped holding piece 14 integrally formed on the bottom of the bottle-shaped main body 1. Are formed through the thin fusion-bonded portion 51. Since the holding piece 14 has a hollow plate shape, the cap-shaped re-sealing means 5 is formed as described above. Groove-shaped recessed portions 52, 52 are formed in a continuous state with the attachment portion 51, and the recessed portions 52, 52 on both surfaces of the holding piece 14 are separated by a partition wall 52a.

Since the fusion-bonding portion 51 is thin, if a part of the holding piece 14 and the other portion where the resealing means 5 is formed are separated with a certain amount of force, the fusion-bonding portion 51 is formed. And the partition wall 52a are ruptured, and the resealing means 5 holds the holding piece 14
Disconnected from Therefore, when the bottle-shaped body 1 is opened, the resealing means 5 is separated from the holding piece 14 in advance, and the resealing means 5 is opened after opening the bottle mouth portion 10.
When pressed so as to cover the bottle-shaped main body 1, the ring-shaped convex portion 50 of the resealing means 5 comes into close contact with the outer peripheral surface of the bottle mouth portion 10 in a pressed state, and the bottle-shaped body 1 is resealed. Ring-shaped protrusion 50
As described above, the cap-like re-sealing means 5 cannot be removed unless it is pulled out from the bottle mouth portion 10, because it comes into close contact with the outer peripheral surface of the bottle mouth portion 10 while being pressed. In this embodiment, the ring-shaped convex portion 50 is formed on the inner peripheral portion of the cap-shaped resealing means 5 as described above in order to make the structure highly elastic. The entire inner peripheral surface of the cap-shaped resealing means 5 can be configured to be in close contact with the outer peripheral surface of the bottle mouth 10. Other configurations, actions, and effects of the container in this embodiment are almost the same as those of the container in the first embodiment, and therefore the description thereof will be omitted.

Twelfth Embodiment FIGS. 27 to 29 show an embodiment corresponding to the liquid agent filling container according to claim 15. In this embodiment,
In a part of the holding piece 14 formed integrally with the bottle-shaped body 1,
The plug-like re-sealing means 5a is integrally formed via the thin fusion-bonding part 51, and when the re-sealing means 5a is pushed into the bottle mouth part 10 after opening, the outer peripheral surface thereof is It is configured to be in close contact with the inner peripheral surface of the bottle mouth portion 10.
Since the holding piece 14 has a hollow plate shape, the plug-shaped resealing means 5a is formed. Therefore, the fusion-bonded portions 51 are continuously formed on both sides of the periphery of the resealing means 5 except the base portion. is there. Since the fusion-bonding part 51 is thin, if a part of the holding piece 14 and another part where the re-sealing means 5a is formed are separated, the fusion-bonding part 51 is broken and the re-sealing means 5a is The formed portion can be easily separated from the holding piece 14. Therefore, when the bottle-shaped main body 1 is opened, the resealing means 5a is separated from a part of the holding piece 14 in advance, and after the opening, the resealing means 5a is opened as shown in FIG.
When a is pushed into the bottle mouth portion 10, the outer peripheral surface of the re-sealing means 5a comes into close contact with the inner peripheral surface of the bottle mouth portion 10 in a compressed state, and the bottle-shaped main body 1
Is resealed. Since the resealing means 5a is in close contact with the inner peripheral surface of the bottle mouth portion 10 in a pressed state, the bottle mouth portion 1 must be pulled out with some force from the bottle mouth portion 1
It never goes off. In the container of this embodiment, the entire outer peripheral surface of the portion of the resealing means 5a inserted into the bottle mouth portion 10 is configured to be in close contact with the inner peripheral surface of the bottle mouth portion 10. It can also be carried out by forming a part of the surface so as to be in close contact with the inner peripheral surface of the bottle mouth portion 10. Other configurations and operations of the container in this embodiment
Since the effects are almost the same as those of the container of the first embodiment, their explanations are omitted.

Thirteenth Embodiment FIGS. 30 and 31 show an embodiment corresponding to the liquid agent filling container of claim 16. In this embodiment, a cap-shaped re-sealing means 5 having a ring-shaped convex portion 50 which can be brought into close contact with the outer peripheral surface of the bottle mouth portion 10 on the inner peripheral surface is integrated with the knob portion 20 on the upper portion of the cap 2. Is formed in. The liquid agent filling container of this embodiment is different from the container of the eleventh embodiment only in that the cap-shaped resealing means 5 is formed not on the holding piece 14 but on the knob portion 20 of the cap 2. is there. Therefore, the resealing procedure (FIG. 31), the action, the effect, the fact that the entire inner peripheral surface of the resealing means 5 is in close contact with the outer peripheral surface of the bottle mouth portion 10 can be carried out, and other configurations. Is the eleventh
Since the container is almost the same as that of the embodiment, the description thereof is omitted. Also in this embodiment, the resealing means 5 can be formed on the knob portion 20 through a thin fusion-bonding portion (not shown).

Fourteenth Embodiment FIGS. 32 to 33 show an embodiment corresponding to the liquid agent filling container of claim 17. In this embodiment,
A stopper-like resealing means 5a is integrally formed on the knob portion 20 on the upper portion of the cap 2 so that the outer peripheral surface thereof closely adheres to the inner peripheral surface of the bottle mouth portion 10 when pushed into the opened bottle mouth portion 10. Has been done. The liquid agent filling container of this embodiment is different from the container of the twelfth embodiment only in that the plug-like resealing means 5a is formed not on the holding piece 14 but on the knob portion 20 of the cap 2. is there. Therefore, the resealing procedure (FIG. 33), the action, the effect, and the fact that a part of the outer peripheral surface of the resealing means 5a is configured to be in close contact with the inner peripheral surface of the bottle mouth portion 10, can be implemented. Other configurations are the first
Since it is almost the same as the container of the second embodiment, the description thereof will be omitted. Also in this embodiment, the resealing means 5a can be formed on the knob portion 20 via the thin fusion-bonded portion.

Fifteenth Embodiment FIGS. 34 and 35 show an embodiment corresponding to the liquid agent filling container of claim 18. In this embodiment, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the inner peripheral portion of the skirt portion of the cap 2 is fused to the lower surface of the flange 19a. On one surface of the hollow plate-shaped knob portion 20 formed on the upper portion of the cap 2, a hole 53 having a size capable of pushing the upper end of the bottle mouth portion 10 is formed, and an inner peripheral edge portion of the hole 53 is formed. Is formed with an inward flange 54. The knob portion 20 constitutes a cap-shaped resealing means 5b as a whole, the inner upper surface 55 (FIG. 35) of the hole 53 is smooth, and the inner peripheral portion of the hole 53 is similar to a groove. The recessed portion 56 is formed. According to the liquid agent filling container of this embodiment, when the fusion-bonding portion 40 between the cap 2 and the bottle mouth portion 10 is broken and opened, the resealing means 5b is pressed against the bottle mouth portion 10 to cover the bottle, The mouth portion 10 is pushed into the hole 53. At this time, as shown in FIG. 35, the flange 19a is locked to the inward flange 54 so as not to come off, and the opening edge 1 of the bottle mouth 10 is closed.
The bottle-shaped main body 1 is resealed because 0a comes into close contact with the inner upper surface 55 of the hole 53. When the bottle mouth portion 10 is pulled out from the cap-like resealing means 5b, the flange 19a passes through the inward flange 54 and comes out of the hole 53, and the bottle mouth portion 10 is resealed. Other configurations, actions, and effects of the container in this embodiment are almost the same as those of the container in the first embodiment, and therefore the description thereof will be omitted.

Sixteenth Embodiment FIGS. 36 and 37 show an embodiment corresponding to the liquid agent filling container of claim 19. In this embodiment, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and the inner peripheral portion of the skirt portion of the cap 2 is fused to the lower surface of the flange 19a. On one surface of the hollow plate-shaped knob portion 20 formed on the upper portion of the cap 2, a groove portion 57 having a size into which the upper end portion of the bottle mouth portion 10 can be inserted is formed.
An inward flange 54 is formed on the inner peripheral edge of the. The entire knob portion 20 constitutes a cap-shaped resealing means 5c, and the inner upper surface 58 of the groove portion 57 is formed.
(FIG. 37) is smooth, and a recess 56 similar to a dovetail groove is formed around the inside of the groove 57. After the fusion-bonding portion 40 between the cap 2 and the bottle mouth portion 10 is broken and opened, the upper end portion of the bottle mouth portion 10 is slid into the groove portion 57 and inserted, as shown in FIG. The opening edge 10a of the bottle mouth portion 10 is locked to the facing flange 54 in a retaining manner, and the inner upper surface 5 of the groove portion 57 is formed.
The bottle-shaped main body 1 is re-sealed because it closely contacts with 8. When the bottle mouth portion 10 is slid with respect to the groove portion 57 and the cap-shaped resealing means 5c is removed from the bottle mouth portion 10, the bottle mouth portion 10 is resealed. Other configurations, actions, and effects of the container in this embodiment are almost the same as those of the container in the fifteenth embodiment, and therefore their description will be omitted.

Seventeenth Embodiment FIG. 38 shows an embodiment corresponding to the liquid agent filling container according to claim 20. In the container of this embodiment,
Similar to the container of the fifteenth embodiment, the flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and a part of the holding piece 14 formed integrally with the bottom portion of the bottle-shaped main body 1 has a part of the fifteenth embodiment. The re-sealing means 5b in the shape of a cap, which is almost the same as the container in the form,
It is formed via a thin fusion-bonded portion 51. According to the container of this embodiment, when the fusion-bonding portion 40 is broken to open the bottle mouth portion 10, the fusion-bonding portion 51 is broken in advance and the resealing means 5b is separated from the holding piece 14,
After opening, the bottle mouth part 1 is processed in the same manner as the container of the fifteenth embodiment.
0 can be resealed. Other configurations, actions, and effects of the container in this embodiment are almost the same as those of the container in the fifteenth embodiment, and therefore their description will be omitted.

18th Embodiment FIG. 39 shows an embodiment corresponding to the liquid agent filling container according to claim 21. In the container of this embodiment,
Similar to the container of the sixteenth embodiment, a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10, and a part of the holding piece 14 integrally formed on the bottom portion of the bottle-shaped main body 1 is provided with the sixteenth embodiment. The cap-like re-sealing means 5c, which is almost the same as the container of
It is formed via a thin fusion-bonded portion 51. According to the container of this embodiment, when the fusion-bonding portion 40 is broken to open the bottle mouth portion 10, the fusion-bonding portion 51 is broken in advance and the resealing means 5b is separated from the holding piece 14,
After opening, the bottle mouth part 1 is processed in the same manner as the container of the 16th embodiment.
0 can be resealed. Other configurations, actions, and effects of the container in this embodiment are almost the same as those of the container in the sixteenth embodiment, and therefore their description will be omitted.

In the liquid agent filling containers of the first to fourth embodiments, the small and medium plugs 28 can be formed on the inner upper surface of the cap 2 in substantially the same manner as the containers of the sixth to ninth embodiments.

[0063]

According to the liquid agent filling container of the first aspect, the resealing means 3 is provided in either or both of the bottle mouth portion 10 of the bottle-shaped body 1 and the body portion of the cap 2.
Even if the cap 2 is once broken and opened from the fusion bonding portion 40, the cap 2 can be recapped in the bottle mouth portion 10 in a hermetically sealed state. Therefore, especially in a unit-dose type container, it is very convenient to fill the liquid agent for several times and carry it repeatedly as needed, and at the same time, it is economical to use in a unit-dose type container. The efficiency can be increased.

According to the liquid medicine filling container of the second aspect, when the cap 2 is resealed, the cap 2 and the bottle mouth portion 10 are lightly locked to each other in the pulling direction in the resealed state. Since it is provided with the locking means 4 for
This is particularly effective when the cap 2 has a structure in which it can be easily removed from the bottle mouth 10. If the locking means 4 is composed of a convex portion formed on the outer peripheral portion of the bottle mouth portion 10 and a convex portion formed on the inner peripheral portion of the cap 2, the cap is When sealed, the convex portions are locked to each other in the direction in which the cap 2 is prevented from coming off, so that the existence of the locking means 4 and the operating procedure can be easily recognized.

According to the liquid medicine filling container of claim 3, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the small-diameter portion 21 formed on the inner peripheral portion of the cap 2 becomes the bottle mouth portion 10. And the bottle-shaped body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped body 1 is resealed. Therefore, the resealing and resealing operations are very simple.

According to the liquid medicine filling container of claim 4, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the tapered inner peripheral surface 23 of the conical surface formed on the inner peripheral portion of the cap 2 is formed. Comes into close contact with the upper outer peripheral edge of the bottle mouth portion 10, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped body 1 is resealed. Therefore, the resealing and resealing operations are very simple.

According to the liquid agent filling container of claim 5, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the conical tapered surface 12 formed on the upper outer peripheral portion of the bottle mouth portion 10 is pressed. And the taper inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 come into close contact with each other, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of claim 6, when the cap 2 is screwed to the bottle mouth 10 after opening, the bottle-shaped main body 1
Is resealed, and it is reopened when screwed back in the loosening direction. Therefore, resealing and resealing are very easy. Also,
In the liquid agent filling container of this aspect, the cap 2 does not easily come off from the bottle mouth portion 10 in the resealed state even without the locking means 4.

According to the liquid agent filling container of the seventh aspect, when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening, the inner plug 26 formed on the inner upper surface of the cap 2 is inside the upper portion 10 of the bottle mouth portion. The bottle-shaped main body 1 is resealed by closely contacting the peripheral portion. When the cap 2 is pulled out from the mouth of the bottle, the bottle-shaped body 1
Will be reopened. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of the eighth aspect, when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening, the ring-shaped convex portion 27 of the inner peripheral portion of the cap 2 becomes the outer periphery of the bottle mouth portion 10. The bottle-shaped main body 1 is resealed by closely adhering to the surface. When the cap 2 is pulled out from the bottle mouth portion 10, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid-filled container of claim 9, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the ring-shaped convex portion formed on the outer peripheral surface of the bottle mouth portion 10 becomes 17 Comes into close contact with the inner peripheral surface of the cap, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2,
The bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid medicine filling container of claim 10, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the outer peripheral surface of the large diameter bottle neck portion formed at the base portion of the bottle mouth portion 10 is removed. The bottle-shaped main body 1 is resealed by closely contacting the inner peripheral surface of the hem of the cap 2. When the bottle mouth 10 is pulled out from the cap 2,
The bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of claim 11, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, the tapered outer peripheral surface 15a of the bottle shoulder portion 15 and the inner peripheral surface of the skirt portion of the cap 2 are formed. And the bottle-shaped body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid medicine filling container of claim 12, when the cap 2 after opening is pressed so as to cover the bottle mouth portion 10, to the lower portion of the flange 19 formed on the outer periphery of the upper portion of the bottle mouth portion 10, The inward flange 29 formed on the inner peripheral surface of the skirt portion of the cap 2 is tightly locked, and the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the cap 2, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of claim 13, in the container according to any one of claims 3, 4, 5, 6, 8 to 12, the cap 2 after opening is bottled on the upper inner surface of the cap 2. When pressed so as to cover the mouth portion 10, the small and medium plug 28 is formed so as to close the opening of the bottle mouth portion 10, so that the bottle-shaped main body 1 is completely resealed.

According to the liquid medicine filling container of claim 14, before opening the bottle-shaped main body 1, the cap-shaped resealing means 5 is previously separated from the holding piece 14 by the thin fusion portion 51, and after the opening, When the resealing means 5 is pressed against the bottle mouth portion 10, the inner peripheral surface of the cap-shaped resealing means 5 is brought into close contact with the outer peripheral surface of the bottle mouth portion 10, and the bottle-shaped body 1 is resealed. When the bottle mouth 10 is pulled out from the resealing means 5, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of the fifteenth aspect, before the bottle-shaped main body 1 is opened, the plug-like resealing means 5a is previously separated from the holding piece 14 by the thin fusion portion 51, and the resealing is performed. Pushing the means into the bottle mouth reseals the bottle body. When the resealing means is pulled away from the mouth of the bottle, it is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of the sixteenth and eighteenth aspects, when the cap-shaped resealing means 5 or 5b formed on the upper portion of the cap 2 is pressed against the bottle mouth portion 10 after opening, The bottle-shaped body 1 is resealed. When the resealing means 5 or 5b is separated from the bottle mouth portion 10, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid medicine filling container of the seventeenth aspect, when the stopper-like resealing means 5a formed on the upper portion of the cap 2 is pushed into the bottle mouth portion 10 after opening, the bottle-shaped main body 1 is resealed. It When the resealing means 5a is pulled out from the bottle mouth portion, the bottle-shaped main body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of the nineteenth aspect, the bottle mouth part 1 after opening in the groove part 57 of the cap-like resealing means 5c.
When the upper end of 0 is slid and inserted, the bottle-shaped body 1 is resealed. Slide the bottle mouth part 10 to make the groove part 5
When removed from 7, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of claim 20, before opening the bottle-shaped main body 1, the cap-like resealing means 5b is previously separated from the holding piece 14 by the thin fusion-bonding portion 51, and after opening the container, When the resealing means 5b is pressed against the bottle mouth portion 10 after opening, the bottle-shaped main body 1 is resealed. When the bottle mouth 10 is pulled out from the resealing means 5b,
The bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of claim 21, before opening the bottle-shaped main body 1, the cap-shaped resealing means 5c is previously separated from the holding piece 14 by the thin fusing portion 51, and the resealing is performed. When the bottle mouth 10 after opening is slid and inserted into the groove 57 of the means 5c, the bottle-shaped main body 1 is resealed. Slide the bottle mouth portion 10 into the groove portion 5
When 7 is pulled out, the bottle-shaped body 1 is resealed. Therefore, resealing and resealing are very easy.

According to the liquid agent filling container of the twenty-second aspect, since the antibacterial zeolite is dispersed and held on the entire surface or a required portion, for example, as shown in Test Example-1, the liquid agent filled inside is , Is sterilized by the antibacterial metal ions retained in the antibacterial zeolite. Therefore, it is not necessary to mix an antiseptic with the liquid agent in advance in order to prevent contamination or secondary contamination of the liquid agent due to various bacteria. Further, for example, as shown in Test Example-2, since the container itself is completely safe, a liquid-filled container which does not contain a preservative and can be used repeatedly and which has high safety is provided. .

According to the liquid medicine filling container of the twenty-third aspect, it is very convenient because it is not necessary to fill the container having a large capacity with the eye drops and carry it.

[Brief description of drawings]

FIG. 1 is a partial cross-sectional view showing a first embodiment of a liquid agent filling container according to the present invention.

2 is a perspective view showing the entire container of FIG. 1. FIG.

FIG. 3 is a partial cross-sectional view of the container of FIG. 1 in a state where the bottle mouth portion is resealed.

FIG. 4 is a partial cross-sectional view showing a second embodiment of the liquid agent filling container according to the present invention.

5 is a partial cross-sectional view of the container of FIG. 4 in a state where the bottle mouth portion is resealed.

FIG. 6 is a partial cross-sectional view showing a third embodiment of the liquid agent filling container according to the present invention.

7 is a partial cross-sectional view of the container of FIG. 6 in a state where the bottle mouth portion is resealed.

FIG. 8 is a partial cross-sectional view showing a fourth embodiment of a liquid agent filling container according to the present invention.

FIG. 9 is a partial cross-sectional view showing a fifth embodiment of the liquid agent filling container according to the present invention.

FIG. 10 is a partial cross-sectional view showing a sixth embodiment of the liquid agent filling container according to the present invention.

FIG. 11 is a perspective view showing the entire container of FIG.

12 is a partial cross-sectional view of the container of FIG. 10 in a state where the bottle mouth portion is resealed.

13 is a partial cross-sectional view showing a modified example of the container of FIG.

FIG. 14 is a partial cross-sectional view of the container of FIG. 13 in a state where the bottle mouth portion is resealed.

FIG. 15 is a partial cross-sectional view showing a seventh embodiment of the liquid agent filling container according to the present invention.

16 is a partial cross-sectional view of the container of FIG. 15 in a state where the bottle mouth portion is resealed.

FIG. 17 is a partial sectional view showing an eighth embodiment of the liquid agent filling container according to the present invention.

FIG. 18 is a partial cross-sectional view of the container of FIG. 17 in a state where the bottle mouth portion is resealed.

FIG. 19 is a partial sectional view showing a ninth embodiment of the liquid agent filling container according to the present invention.

20 is a partial cross-sectional view of the container of FIG. 19 in a state where the bottle mouth portion is resealed.

FIG. 21 is a partial cross-sectional view showing a tenth embodiment of the liquid agent filling container according to the present invention.

22 is a partial cross-sectional view of the container of FIG. 21 in a state where the bottle mouth portion is resealed.

FIG. 23 is a partial sectional view showing an eleventh embodiment of a liquid agent filling container according to the present invention.

24 is a sectional view of the container of FIG. 23 taken along the arrow AA.

25 is a cross-sectional view of the container of FIG. 23 taken along the arrow BB.

FIG. 26 is a partial cross-sectional view of the container of FIG. 23 in a state where the bottle mouth portion is resealed.

FIG. 27 is a partial cross-sectional view showing a twelfth embodiment of the liquid agent filling container according to the present invention.

28 is a cross-sectional view of the container of FIG. 27 taken along arrow CC.

29 is a partial cross-sectional view of the container of FIG. 27 in a state where the bottle mouth portion is resealed.

FIG. 30 is a partial sectional view showing a thirteenth embodiment of a liquid agent filling container according to the present invention.

31 is a partial cross-sectional view of the container of FIG. 30 in a state where the bottle mouth portion is resealed.

FIG. 32 is a partial cross-sectional view showing a fourteenth embodiment of a liquid agent filling container according to the present invention.

FIG. 33 is a partial cross-sectional view of the container of FIG. 32 in a state where the bottle mouth portion is resealed.

FIG. 34 is a partial sectional view showing a fifteenth embodiment of a liquid agent filling container according to the present invention.

FIG. 35 is a partial cross-sectional view of the container of FIG. 34 in a state where the bottle mouth portion is resealed.

FIG. 36 is a partial sectional view showing a sixteenth embodiment of a liquid agent filling container according to the present invention.

37 is a partial cross-sectional view of the container of FIG. 36 in a state where the bottle mouth portion is resealed.

FIG. 38 is a partial cross-sectional view showing a seventeenth embodiment of a liquid agent filling container according to the present invention.

FIG. 39 is a partial sectional view showing an eighteenth embodiment of the liquid agent filling container according to the present invention.

FIG. 40 is a graph showing changes in body weight of male mice after the solution-filled container manufactured according to the embodiment of FIG. 1 was extracted with physiological saline and cottonseed oil and the extracts were administered.

[Explanation of symbols]

 a liquid agent 1 bottle-shaped main body 10 bottle mouth portion 10a opening 11,22 convex portion 12 tapered surface 13 male screw 14 holding piece 15 bottle shoulder portion 15a tapered surface 16 connection portion 17 ring-shaped convex portion 18 bottle neck portion 19, 19a flange 2 Cap 20 Knob part 21 Small diameter part 23 Tapered inner peripheral surface 24 Tapered inner peripheral surface 25 Female screw 26 Inner plug 27 Ring-shaped convex portion 28 Small and medium plug 29 Inward flange 3 Resealing means 4 Locking means 40 Fusion part 5 , 5a, 5b, 5c Re-sealing means 50 Ring-shaped convex portion 51 Thin fusion-bonded portion 52 Groove-shaped concave portion 52a Partition wall 53 Hole 54 Inward flange 55 Inner upper surface of hole 53 56 Groove-like concave portion 57 Groove portion 58 Inner upper surface of groove 57

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Tomohiro Otsuki 3-24-1 Takada, Toshima-ku, Tokyo Within Taisho Pharmaceutical Co., Ltd. (72) Inori Takanori Kodangi 3-24-1 Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Muneyoshi Kato 3-24-1 Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd.

Claims (23)

[Claims] 1. A synthetic resin bottle-shaped body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fused portion 40 between the bottle-shaped body 1 and the cap 2 is broken. The bottle mouth portion 10 and the main body portion of the cap 2 are resealed when the cap 2 is put on the bottle mouth portion 10. Resealing means 3
A liquid agent filling container, wherein the liquid agent filling container is formed. 2. The cap 2 and the bottle mouth portion 10 are provided with locking means 4 which are lightly locked with respect to the pulling direction in the resealed state when the cap 2 is resealed.
The liquid agent filling container according to claim 1, which comprises: 3. The resealing means 3 is in a state in which when the cap 2 is pressed to cover the bottle mouth portion 10 after opening, the resealing means 3 is brought into close contact with the outer peripheral surface of the bottle mouth portion 10.
The small diameter portion 21 formed on the inner side of the groove,
The liquid agent filling container according to [4]. 4. The resealing means 3 of the cap 2 is brought into close contact with the upper outer peripheral edge portion of the bottle mouth portion 10 when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening. The liquid agent filling container according to claim 1 or 2, wherein the tapered inner peripheral surface 23 is a conical surface formed on the inner peripheral portion. 5. The resealing means 3 presses the conical tapered surface 12 formed on the outer periphery of the upper portion of the bottle mouth portion 10 and the cap 2 so as to cover the bottle mouth portion 10 after opening. 3. The liquid agent filling container according to claim 1 or 2, which further comprises a tapered inner peripheral surface 24 formed on the inner peripheral portion of the cap 2 so as to be in close contact with the tapered surface 12. 6. The resealing means 3 has a male screw 13 formed on the outer peripheral surface of the bottle mouth portion 10 and a female screw formed on the inner peripheral surface of the cap 2 in a state of being fitted to the male screw 13. 25. The liquid agent filling container according to claim 1, which is configured with 25. 7. The resealing means 3 is in a state of being in close contact with at least an upper inner peripheral edge of the bottle mouth portion 10 when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening. Stopper 2 formed on the inner upper surface of the
The liquid agent filling container according to claim 1 or 2, which is 6. 8. The re-sealing means 3 is configured such that, when the cap 2 is pressed to cover the bottle mouth portion 10 after opening, the inner circumference of the cap 2 is brought into close contact with the outer peripheral surface of the bottle mouth portion 10. The liquid agent filling container according to claim 1, which is a ring-shaped convex portion 27 formed on the portion. 9. The resealing means 3, when the cap 2 is pressed to cover the bottle mouth 10 after opening, the outer circumference of the bottle mouth 10 is brought into close contact with the inner peripheral surface of the cap 2. The liquid agent filling container according to claim 1, which is a ring-shaped convex portion 17 formed on the surface. 10. The resealing means 3 of the bottle mouth portion 10 is brought into close contact with the inner peripheral surface of the hem portion of the cap 2 when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening. The liquid agent filling container according to claim 1 or 2, which is a bottle neck portion 18 formed on the base portion and having an outer diameter larger than the outer diameter of the bottle mouth portion 10 and slightly smaller than the inner diameter of the cap 2. 11. The resealing means 3 of the bottle mouth portion 10 is in a state of being in close contact with the inner peripheral surface of the skirt portion of the cap 2 when the cap 2 is pressed so as to cover the bottle mouth portion 10 after opening. The liquid agent filling container according to claim 1 or 2, which is the tapered outer peripheral surface 15a of the bottle shoulder portion 15 formed continuously to the base portion. 12. The resealing means 3 includes the bottle mouth portion 10.
The flange 19 formed on the outer circumference of the upper part of the cap 2 and the hem of the cap 2 are tightly locked to the lower part of the flange 19 when the cap 2 is pressed to cover the bottle mouth part 10 after opening. The liquid agent filling container according to claim 1, which is configured with an inward flange 29 formed on an inner peripheral surface of the portion. 13. The inside / outside plug 28 is attached to the upper inner surface of the cap 2 so as to close the opening edge 10a of the bottle mouth portion 10 when the cap 2 is pressed to cover the bottle mouth portion 10 after opening. Are formed,
The liquid agent filling container according to any one of 6, 8 to 12. 14. A synthetic resin bottle-shaped main body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fused portion 40 between the bottle-shaped main body 1 and the cap 2 is broken. Then, a plate-shaped holding piece 14 is formed along the lengthwise direction of the bottle-shaped main body 1 at the bottom of the bottle-shaped main body 1, and a part of the holding piece 14 is formed. , Cap-shaped resealing means 5
Is formed through a thin fusion-bonded portion 51, and when the resealing means 5 covers the bottle mouth portion 10 with the resealing means 5 after opening, at least part of the inner peripheral surface is the bottle mouth. A liquid agent filling container, which is configured to be in close contact with the outer peripheral surface of the portion 10. 15. A synthetic resin bottle-shaped body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fused portion 40 between the bottle-shaped body 1 and the cap 2 is broken. Then, a plate-shaped holding piece 14 is formed along the lengthwise direction of the bottle-shaped main body 1 at the bottom of the bottle-shaped main body 1, and a part of the holding piece 14 is formed. The plug-like resealing means 5a is formed via the thin-walled fusion-bonding part 51, and the resealing means 5a has an outer peripheral surface when the resealing means 5a is pushed into the bottle mouth 10 after opening. A liquid agent filling container, characterized in that at least a part thereof is configured to come into close contact with the inner peripheral surface of the bottle mouth portion 10. 16. A synthetic resin bottle-shaped body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fused portion 40 between the bottle-shaped body 1 and the cap 2 is broken. Then, a cap-shaped resealing means 5 is formed on the upper portion of the cap 2, and the resealing means 5 covers the bottle mouth portion 10 with the resealing means 5 after opening. At the same time, at least a part of the inner peripheral surface is configured to be in close contact with the outer peripheral surface of the bottle mouth portion 10, wherein the liquid medicine filling container. 17. A synthetic resin bottle-shaped body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fusion-bonded portion 40 between the bottle-shaped body 1 and the cap 2 is broken. And a cap-shaped re-sealing means 5a is formed on the upper portion of the cap 2, and when the re-sealing means 5a is pushed into the bottle mouth portion 10 after opening. In addition, the liquid agent filling container, wherein at least a part of the outer peripheral surface is configured to be in close contact with the inner peripheral surface of the bottle mouth portion 10. 18. A synthetic resin bottle-shaped body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fusion-bonded portion 40 between the bottle-shaped body 1 and the cap 2 is broken. The bottle mouth 10 is formed with a flange 19a on the outer periphery of the upper end thereof, and the cap 2 has a cap-like resealing means 5b.
The re-sealing means 5b is directed inward toward the inner peripheral portion so that the flange 19a is locked in a retaining manner when the re-sealing means 5b is put on the bottle mouth portion 10 after opening. A liquid medicine filling container, which has a flange 54, and is configured such that the inner upper surface 55 is in close contact with the opening edge 10a of the bottle mouth portion 10. 19. A synthetic resin bottle-shaped body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fused portion 40 between the bottle-shaped body 1 and the cap 2 is broken. And a flange 19a is formed on the outer peripheral portion of the upper end of the bottle mouth portion 10 of the bottle-shaped main body 1, and the upper end portion of the bottle mouth portion 10 is inserted into the upper portion of the cap 2. A cap-shaped re-sealing means 5c having a groove portion 57 of a size to be obtained is formed, and the groove portion 57 prevents the flange 19a from coming off when the upper end portion of the bottle mouth portion 10 is inserted into the groove portion 57 after opening. A liquid medicine filling container, characterized in that it has an inward flange 54 that is locked in a circular shape at its inner peripheral portion, and is configured such that the inner upper surface 58 is in close contact with the opening edge 10a of the bottle mouth portion 10. 20. A synthetic resin bottle-shaped main body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fusion-bonded portion 40 between the bottle-shaped main body 1 and the cap 2 is broken. The bottle mouth 10 is formed with a flange 19a on the outer periphery at the upper end thereof, and the bottom of the bottle-shaped body 1 has a plate shape along the length direction of the bottle-shaped body 1. Holding piece 14 is formed, a plate-like holding piece 14 is formed on the bottom of the bottle-shaped main body 1 along the length direction of the bottle-shaped main body 1, and a cap-shaped holding piece 14 is formed on a part of the holding piece 14. Resealing means 5b
Is formed through a thin fusion-bonding portion 51, and the resealing means 5b is locked so that the flange 19a does not come off when the resealing means 5b is put on the bottle mouth 10 after opening. Has an inwardly facing flange 54 on the inner periphery, and the inner upper surface 55 has an opening edge 10 of the bottle mouth 10.
A liquid agent filling container, which is configured to be in close contact with a. 21. A synthetic resin bottle-shaped main body 1 having a bottle mouth portion 10 is fusion-sealed with a synthetic resin cap 2, and the fusion-bonded portion 40 between the bottle-shaped main body 1 and the cap 2 is broken. The bottle mouth 10 is formed with a flange 19a on the outer periphery at the upper end thereof, and the bottom of the bottle-shaped body 1 has a plate shape along the length direction of the bottle-shaped body 1. The holding piece 14 is formed, and a cap-shaped resealing means 5c having a groove portion 57 having a size into which the upper end portion of the bottle mouth portion 10 can be inserted is formed in a part of the holding piece 14. The groove portion 57 is formed by inserting the inwardly facing flange 54 into which the flange 19a is locked so as not to come off when the upper end portion of the bottle mouth portion 10 is inserted into the groove portion 57 after opening. The inner upper surface 58 is provided at the peripheral portion and the inner upper surface 58 has the opening edge 1 of the bottle mouth portion 10. Characterized in that it is constructed in a state of close contact to a, liquid-filled container. 22. The liquid agent filling container according to claim 1, wherein the antibacterial zeolite is dispersed and held on the entire surface or a required portion. 23. The liquid agent filling container according to claim 1, wherein the container is an eye drop filling container.