JPH09174687A - Chemical liquid vessel and manufacture thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To facilitate the piercing operation of a needle while holding the stable strength of drape by fusion bonding the end face of the lower part of te port of a vessel to the wall surface of the upper part of a vessel body, orienting the wall surface of the upper part of the body in contact with the space inside the port into the space, and fusion bonding it to the inner wall surface and partition wall of the port. SOLUTION: A partition wall 7 formed with a hole 7a is formed in the port 2 of the vessel. The lower part end face 4 and the inner wall surface 4a of the port 1 as well as the wall surface 5 of the upper part of a vessel body 3 in which chemical liquid is filled are heated to be melted, and the face 4 and the surface 5 are pressed to be fusion bonded. An adapter 8 is, for example, mounted in the opening 6 of the port 2, a suction device 10 is connected thereto via a tube 9, and the spaces S, S2 in the port 2 are sucked to be pressure- reduced. The upper part wall surface 5a in contact with the space S2 communicating with the space S is sucked toward the space S, oriented, and fusion bonded to the inner wall surface 5a and wall 7 in, the port 2. The partition wall 7 suppresses that the face 5a in contact with the space S2 is sucked more than necessary to be oriented.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a chemical solution container made of synthetic resin and a method for producing the same, and a chemical solution container having a diaphragm formed on the upper wall surface of the container body after heat-welding the mouth and the container body and the same. The present invention relates to a manufacturing method.

[0002]

2. Description of the Related Art A chemical solution container is usually manufactured by heat welding by sandwiching a hard mouth formed by injection molding between two flexible synthetic resin sheets. Has been done. Since the shape of the mouth is formed in a cylindrical shape, when sandwiched between the sheets and sealed,
The liquid sometimes leaked from the periphery of the welded portion of the mouth to the sheet. It is also proposed that the mouth sheet welded part is formed in a boat shape to prevent liquid leakage, but the hardness of the material of the mouth part and the sheet is different, and the seat is completely welded even in the boat type. It was not possible to completely eliminate the liquid leakage due to the difficulty. In addition, the applicant of the 1994 patent application No. 194751 welds the lower end face of the mouth portion to the upper wall surface of the container body and extends the upper wall surface of the container body in contact with the space inside the mouth portion into the space to form a diaphragm. We proposed a chemical solution container and a manufacturing method thereof. However, when the upper wall surface of the container body is extended into the space of the mouth, it extends too deep into the space of the mouth and penetrates deeply, the wall thickness becomes thin and the waist becomes weak, making it difficult for the needle to pierce when puncturing the needle. There was a problem of becoming.

[0003]

[Means for Solving the Problems]

[1] The present invention provides a method for manufacturing a drug solution container, which comprises the following steps. (1) A step of heating and melting the lower end face of the mouth portion and an upper wall surface of the container body, (2) a step of pressing and welding the lower end face of the mouth portion and an upper wall surface of the container body, (3) an opening portion of the mouth portion The suction device attached to the suction part sucks the inside of the mouth to a reduced pressure, the upper wall surface of the container body is stretched, and the inner wall surface of the mouth part and the partition wall are welded. (4) The rubber plug is attached to the mouth part The process of capping the

[2] The present invention provides a method for manufacturing a chemical liquid container, which comprises the following steps. (1) A step of extruding a heating and melting tube from an extrusion die,
(2) A step of welding a mouth portion whose lower end face is heated and melted to a heating / melting tube, (3) a suction device attached to the opening portion of the mouth portion sucks the inside of the mouth portion to a reduced pressure to stretch the upper wall surface of the container body. The step of welding to the inner wall surface of the mouth and the partition wall,
(4) A step of fusing (or fusing at the same time as sealing) after sealing the tube to a predetermined length, (5) a step of attaching a rubber stopper to the mouth and capping the rubber stopper with a cap,

[3] The present invention provides a method for manufacturing a chemical liquid container, which comprises the following steps. (1) heating and melting the lower end surface of the mouth and the upper wall surface of the container body, respectively (2) pressing and welding the lower end surface of the mouth and the upper wall surface of the container body, (3) from the inside of the container body A step of pressing the upper wall surface of the container main body with a pressing jig to extend it, and welding it to the inner wall surface of the mouth and the partition wall;
(4) A step of attaching a rubber stopper to the mouth and capping the rubber stopper, (5) A step of filling a chemical solution from the bottom of the container body, and then sealing.

[4] The present invention provides a method for manufacturing a chemical liquid container, which comprises the following steps. (1) A step of extruding a heating and melting tube from an extrusion die,
(2) A step of welding a mouth portion whose lower end face is heated and melted to the heat melting tube, (3) an upper wall surface of the tube is pressed and stretched from the inside of the tube by a pressing jig, and an inner wall surface and a partition wall of the mouth portion And (4) sealing the tube to a predetermined length and then fusing (or fusing at the same time as the sealing), (5) attaching a rubber stopper to the mouth, and capping the rubber stopper. Process,

[5] The present invention provides a method for manufacturing a chemical liquid container comprising the following steps. (1) A step of extruding a heating and melting tube from an extrusion die,
(2) Cooling and folding the heating and melting tube,
(3) heating and melting the lower end face of the mouth and the upper wall surface of the container body, respectively (4) pressing and welding the lower end face of the mouth and the upper wall surface of the container body, (5) opening of the mouth The suction device attached to the step of suctioning the inside of the mouth to a reduced pressure, extending the upper wall surface of the container body and welding to the inner wall surface of the mouth part and the partition wall, (6) attaching a rubber stopper to the mouth portion, A step of capping the cap, (7) a step of filling the tube with a chemical solution, (8) a step of sealing the tube to a predetermined length and then fusing (or fusing at the same time as the sealing),

[6] According to the present invention, the lower end face of the mouth portion is welded to the upper wall surface of the container body, and the upper wall surface of the container body that is in contact with the space inside the mouth portion is extended into the space so that Provided is a drug solution container welded to a wall surface and a partition wall.

[7] According to the present invention, the lower end face of the mouth is welded to the upper wall surface of the container body, and the upper wall surface of the container body that is in contact with the space inside the mouth is extended into the space so that the inside of the mouth Welded to the wall and partition wall, the mouth part has a hole and the partition wall curved upward is integrally formed on the upper part and the inner wall surface is tapered, and a rubber stopper is attached to the opening part of the mouth part. Then, a chemical solution container is provided in which the bottom portion of the rubber stopper is close to the partition wall.

[0010]

1 is a schematic view of a chemical liquid container 1 (see FIG. 2).
1 is a view taken in the direction of arrow A in FIG. 1). In the chemical solution container 1, a lower end face 4 of a cylindrical mouth portion 2 made of a hard or semi-hard synthetic resin is attached to an upper wall surface 5 of a flexible synthetic resin bag-shaped container body 3. It is composed by welding. Next, an example of a method of manufacturing the chemical liquid container 1 will be described. As shown in FIG. 3, a partition 7 having a hole 7a is formed in the mouth 2. First, the lower end surface 4 and the inner wall surface 4a of the mouth portion 2 and the upper wall surface 5 of the container body 3 filled with the chemical solution are respectively heated and melted, and the lower end surface 4 and the upper wall surface 5 are pressed and welded. The opening 6 of the mouth 2 as shown in FIG.
For example, an adapter 8 (a rubber stopper having a slit may be used, or the one whose slit is closed after the tube 9 is removed) is attached to the suction device 1 through the tube 9.
0 is connected and the spaces S and S2 in the mouth portion 2 are sucked to a reduced pressure. The upper wall surface 5a, which is in contact with the space S2 communicating with the space S through the partition wall 7 of the container body 3, is sucked and extended in the direction of the space S2 and welded to the inner wall surface 4a of the opening 2 and the partition wall 7.
The partition wall 7 suppresses the end surface 5a in contact with the space S2 from being sucked into the space S more than necessary and extending.

The upper wall surface 5a in contact with the space S2 is a diaphragm 11
Therefore, it is necessary that the puncture resistance of the needle be reduced and that the container be strong enough to maintain liquid tightness. The stretching area of the upper wall surface 5a in contact with the space S2 is preferably 2 to 6 times, and the thickness after stretching is preferably 100 to 200 μm. If the wall thickness of the container body 3 before stretching (300 to 600 μm) is too thick, it is difficult to break through with a needle, and if it is stretched too much and the wall thickness is 100 μm or less, it easily breaks and acts as the diaphragm 11. Because you can't. The inner diameter of the mouth 2 is 10 to 50.
It is desirable to form it in mm. Space S below 10 mm
The volume of 2 is small, and it is difficult to generate a negative pressure to the extent that the upper wall surface 5a in contact with the space S2 can be stretched. If it is 50 mm or more, the draw ratio of the upper wall surface 5a in contact with the space S2 becomes large and the wall thickness becomes thin, so that the strength of the diaphragm 11 cannot be maintained. Finally, the adapter 8 and the suction device 10 are removed from the mouth 2, the rubber plug 12 is attached to the opening 6 as shown in FIG. 5, and the rubber plug 12 is capped with the cap 13.

FIG. 6 is a schematic view showing an embodiment of another manufacturing method of the chemical liquid container 1. The manufacturing method of FIG.
This is a method of welding the mouth portion 2 obtained by heating and melting the lower end surface 4 while pushing out the heating and melting tube 23 that constitutes the container body 3 from 0. Further, as in Japanese Patent Publication No. 10825/1992, the chemical liquid injection line 24 is arranged so as to penetrate the extrusion die 20, and the chemical liquid is filled from this.

The mouth portion 2 is attached to the tip of the vacuum tube 22 of the suction device 10, and the heat-melted lower end surface 4 of the mouth portion 2 is pressed against the heat-melting tube 23 so that the inside of the heat-melting tube 23 outlet of the extrusion die 20 is pressed. The lower end face 4 of the mouth 2 is heated and melted by welding both the pressure bonding plate 21 provided and the vacuum tube 22 of the suction device 10.
3 can be welded. Subsequently, the inside of the mouth portion 2 is sucked by the suction device 10 to reduce the pressure, and the upper wall surface 25a of the heating and melting tube 23 that comes into contact with the space S2 of the mouth portion 2 is stretched to form the inner wall surface 4a of the mouth portion 2 and the partition wall 7. Weld. Subsequently, as shown in FIG. 7, after the heating and melting tube 23 is sealed in a predetermined shape by the sealing mold 25, it is melted by the melting mold 26 (or melted at the same time as the sealing), and the container main body 3
Shape. Finally, as in FIG. 5, the rubber stopper 12 is attached to the opening 6 of the mouth portion 2, and the cap 13 is attached to the rubber stopper 12.

FIGS. 8 and 9 are schematic views showing another embodiment of the method for manufacturing the chemical liquid container 1. 3 to 5, in place of vacuum suction of the spaces S and S2 of the mouth portion 2, the upper wall surface 5a of the container body 3 is pressed and extended from the inside of the container body 3 by the pressing jig 27 to extend the upper wall surface 5a and the mouth. This is a method of welding the inner wall surface 4a in the portion 2 and the partition wall 7. After the rubber stopper 12 and the cap 13 are capped as shown in FIG. 5, a chemical solution is filled and sealed from the bottom of the container body 3 (others are substantially the same as those in FIGS. 3 to 5, so detailed description will be omitted). Omitted). FIG. 10 is a schematic view showing an embodiment of another manufacturing method of the chemical liquid container. 6 to 7, instead of welding both the pressure bonding plate 21 provided inside the outlet of the heating and melting tube 23 of the extrusion die 20 and the vacuum tube 22 of the suction device 10, the inside of the outlet of the heating and melting tube 23 of the extrusion die 20 is welded. Both the pressing jig 28 (which is attached to the jig fixture 29 and is movable in the direction of the arrow (the direction of the mouth 2)) and the jig 22a that clamps the mouth 2 are pressed against the heating and melting tube. As shown in FIGS. 8 and 9, the upper wall surface 25a of the heating and melting tube 23 is pressed by the pressing jig 28 to extend from the inside of 23, and the upper wall surface 25a is welded to the inner wall surface 24a in the mouth 2 and the partition wall 7. In addition, the mouth portion 2 is welded to the heating and melting tube 23 (others are substantially the same as those in FIGS. 6 to 7, and detailed description thereof is omitted). Further, in the present invention, the heating and melting tube 23 extruded from the extrusion die 20 is once cooled and folded, and then the mouth 2 can be welded by the means shown in FIGS. 3 to 5. Finally, after filling the chemical solution into the heating and melting tube 23, it can be sealed in a predetermined shape and melted (or melted at the same time as sealing) as in FIG. 7 to form the container body 3.

FIG. 11 is a schematic view of a mouth portion 32 showing another embodiment of the present invention. There is a hole 37 at the top of the mouth 32
A partition wall 37 that forms a and is curved upward is formed. On the other hand, the lower end surface 34 of the mouth portion 32 is expanded in a brim shape, and the inner wall surface 34a is formed in a taper shape tapering upward. Instead of the mouth portion 2, the mouth portion 32 is welded to the upper wall surface of the container body of the liquid medicine container in the same manner as in FIGS. 3 to 5, 6 to 7, 8 to 9, and 10 described above. You can As shown in FIG. 12, the rubber plug 4 is provided in the opening 36.
2 and the rubber presser 43 are attached. The bottom of the rubber stopper 42 is close to the partition wall 37. By forming the mouth portion 32 into the shape described above, when the upper wall surface of the container body is extended into the space S2, it can be easily extended along the taper and into the partition wall 37 and the inner wall surface 34a of the upper wall surface. The contact area can be increased and the welding strength can be improved. Further, since the partition wall 37 of the mouth portion 32 is closer to the bottom portion of the rubber stopper 42 than the partition wall 7 of the mouth portion 2, it is easier to puncture the needle. Further, since the lower end surface 34 of the mouth portion 32 is expanded in a brim shape, it can be firmly welded to the upper wall surface of the container body.

[0016]

Effects of the Invention

(1) Since the upper end wall surface 5a of the container body 3 is welded to the lower end surface 4 of the mouth portion 2, the inner wall surface 4a, and the partition wall 7, liquid tightness is enhanced. (2) Since the diaphragm 11 can be formed thin, the puncture resistance of the needle of the infusion set can be reduced (50 to 150).
g / cm ² ). (3) The mouth portion 2 can be easily welded to the container body 3, and expensive conventional sealing equipment is unnecessary. (4) Since it is not necessary to provide a liquid contact cap in the space of the mouth portion 2 communicating with the rubber stopper 12 and the container body 3 and the rubber stopper 12 need not be laminated, the number of parts can be saved. Therefore, the cost can be significantly reduced by the synergistic effect with the above (3). (5) The upper wall surface of the container body is always restrained and welded by the partition wall when it is drawn into the space of the mouth. For this reason, it is possible to maintain a stable waist strength without excessively extending into the space and entering deeply, so that the needle puncturing operation can be easily performed.

[Brief description of the drawings]

FIG. 1 is a schematic view of a liquid medicine container.

FIG. 2 is a view taken in the direction of arrow A in FIG. 1;

FIG. 3 is a schematic view of a connection process of the mouth portion.

FIG. 4 is a schematic view of a connection process of the mouth portion.

FIG. 5 is a schematic view of a connection process of the mouth portion.

FIG. 6 is a schematic view showing another embodiment of the connection process of the mouth portion.

FIG. 7 is a schematic view showing another embodiment of the connection process of the mouth portion.

FIG. 8 is a schematic view showing another embodiment of the connection process of the mouth portion.

FIG. 9 is a schematic view showing another embodiment of the connection process of the mouth portion.

FIG. 10 is a schematic view showing another embodiment of the connection process of the mouth portion.

FIG. 11 is a schematic view showing another embodiment of the mouth portion.

FIG. 12 is a schematic view showing another embodiment of the mouth portion.

[Explanation of symbols]

1 chemical container 2, 32 mouth part 3 container body 4, 34 mouth end face 4a, 34a mouth inner wall surface 5 container body upper wall surface 5a mouth space upper wall surface 25a of container body 25a mouth part Upper wall surface of the tube in contact with the space S2 6,36 Opening of mouth 7,37 Partition walls 7a, 37a Hole 8 Adapter 9 Tube 10 Suction device 11 Septum 12, 42 Rubber stopper 13, 43 Cap 20 Extrusion die 21 Crimping plate 22 Vacuum tube 22a Jig 23 Heating / melting tube 24 Chemical injection line 25 Sealing mold 26 Fusing dies 27, 28 Pressing jig 29 Jig fixture

Claims (7)

[Claims] 1. A method for manufacturing a chemicals container, which comprises the following steps. (1) A step of heating and melting the lower end face of the mouth portion and an upper wall surface of the container body, (2) a step of pressing and welding the lower end face of the mouth portion and an upper wall surface of the container body, (3) an opening portion of the mouth portion The suction device attached to the suction part sucks the inside of the mouth to a reduced pressure, the upper wall surface of the container body is stretched, and the inner wall surface of the mouth part and the partition wall are welded. (4) The rubber plug is attached to the mouth part The process of capping the 2. A method for manufacturing a chemicals container, which comprises the following steps. (1) A step of extruding a heating and melting tube from an extrusion die,
(2) A step of welding a mouth portion whose lower end face is heated and melted to a heating / melting tube, (3) a suction device attached to the opening portion of the mouth portion sucks the inside of the mouth portion to a reduced pressure to stretch the upper wall surface of the container body. The step of welding to the inner wall surface of the mouth and the partition wall,
(4) A step of fusing (or fusing at the same time as sealing) after sealing the tube to a predetermined length, (5) a step of attaching a rubber stopper to the mouth and capping the rubber stopper with a cap, 3. A method for manufacturing a chemicals container, which comprises the following steps. (1) heating and melting the lower end surface of the mouth and the upper wall surface of the container body, respectively (2) pressing and welding the lower end surface of the mouth and the upper wall surface of the container body, (3) from the inside of the container body A step of pressing the upper wall surface of the container main body with a pressing jig to extend it, and welding it to the inner wall surface of the mouth and the partition wall;
(4) A step of attaching a rubber stopper to the mouth and capping the rubber stopper, (5) A step of filling a chemical solution from the bottom of the container body, and then sealing. 4. A method for manufacturing a liquid medicine container, which comprises the following steps. (1) A step of extruding a heating and melting tube from an extrusion die,
(2) A step of welding a mouth portion whose lower end face is heated and melted to the heat melting tube, (3) an upper wall surface of the tube is pressed and stretched from the inside of the tube by a pressing jig, and an inner wall surface and a partition wall of the mouth portion And (4) sealing the tube to a predetermined length and then fusing (or fusing at the same time as the sealing), (5) attaching a rubber stopper to the mouth, and capping the rubber stopper. Process, 5. A method of manufacturing a chemical liquid container, comprising the following steps. (1) A step of extruding a heating and melting tube from an extrusion die,
(2) Cooling and folding the heating and melting tube,
(3) heating and melting the lower end face of the mouth and the upper wall surface of the container body, respectively (4) pressing and welding the lower end face of the mouth and the upper wall surface of the container body, (5) opening of the mouth The suction device attached to the inside of the mouth sucks the inside of the mouth to a reduced pressure, the upper wall surface of the container body is stretched, and the inner wall surface of the mouth portion and the partition wall are welded. (6) A rubber stopper is attached to the mouth portion, and a rubber stopper is attached. A step of capping the cap, (7) a step of filling the tube with a chemical solution, (8) a step of sealing the tube to a predetermined length and then fusing (or fusing at the same time as the sealing), 6. The lower end face of the mouth portion is welded to the upper wall surface of the container body, and the upper wall surface of the container body in contact with the space inside the mouth portion is extended into the space to be welded to the inner wall surface and the partition wall of the mouth portion. A liquid medicine container characterized by the above. 7. The lower end face of the mouth portion is welded to the upper wall surface of the container body, and the upper wall surface of the container body that is in contact with the space inside the mouth portion is extended into the space and welded to the inner wall surface and the partition wall of the mouth portion. Then, the mouth part is formed with a partition wall that forms a hole and is curved upward, and the inner wall surface is formed in a tapered shape, and a rubber stopper is attached to the opening part of the mouth part. A drug solution container characterized in that a bottom portion is close to the partition wall.