JPH09136992A - Antifungal composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antifungal compsn. capable of preventing discoloration of a fabricated product, high in antifungal power, long in period of persistence of antifungal properties, and capable of securing an deodorant effect for the odor of an additive component itself by adding a specific component to chitosan. SOLUTION: This antifungal compsn. comprises chitosan and hinokitiol as the main components. The concn. of a chitosan soln. to be used is pref. 0.01 to 10%. A hinokitiol concn. of at least 0.01% will suffice. Further addn. of an antifungal metal salt to this compsn. is pref. The antifungal metal salt is pref. selected from among water-soluble salts, examples of which include silver salts such as silver nitrate, silver lactate, silver acetate, silver surfate, and silver perchlorate. The amt. of the antifungal metal salt that may be added ranges from at least 0.2ppm based on the chitosan soln., which is such an amt. that it can exhibit antifungal properties, to 100% based on chitosan, which is the maximum amt. in which it can be contained in chitosan.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention is based on hinokitiol or chitosan containing hinokitiol and a metal salt as a base material, and for the purpose of antibacterial and fungicidal treatment, cosmetics, quasi drugs,
The present invention relates to an antibacterial agent composition that can be effectively used in applications such as spraying.

[0002]

2. Description of the Related Art Since chitosan has an antibacterial property by itself, it is added to fibers, cosmetics and the like as a solution or powder and used to impart an antibacterial property. However, its antibacterial property is weak, and it must be used in a large amount in order to impart sufficient antibacterial property to the product. On the other hand, the antibacterial metal salt has a strong antibacterial property and an effect can be obtained by using a small amount thereof, but a ceramic is often used as a carrier and cannot be used as a solution. Further, in the case of the bactericidal sheet material of chitosan disclosed in Japanese Patent Application No. 54-31598, the elution of silver is limited to the surface of chitosan, and the sustainability of antibacterial property is very short. Ion-chitosan bond Chelate bond causes significant discoloration of the sheet due to silver, which is a quality problem for antibacterial products. Furthermore, there are solution-type silver antibacterial agents in which silver ions are dispersed in amino acids and the like, but they tend to discolor odor, and their application is because they dissolve in water again even if they are applied to a processed product (for example, cloth) and then dried. Limited. Further, an antibacterial agent using hinokitiol has a strong odor of hinokitiol itself, is sublimable, and cannot maintain its antibacterial property for a long period of time.

[0003]

As described above, chitosan can be used as a base material in a solution form, a film form, or a powder form, and can be applied to a wide range of applications, but it is desired to utilize its antibacterial property. In this case, since the antibacterial property of itself is weak, it must be used in a large amount, which may affect the quality required for the product. Even if quality problems do not occur, chitosan is expensive and cannot be used in any product. On the other hand, antibacterial agents using hinokitiol also have a problem with odor, persistence of antibacterial property, etc. as described above.

[0004]

The present invention uses chitosan as a base material, and by adding hinokitiol to the base material, discoloration of processed products can be prevented, antibacterial activity is high, and antibacterial duration is extended. An antibacterial composition having a stronger antibacterial activity can be provided by obtaining an effect of deodorizing its own odor and further adding a small amount of antibacterial metal. The solution concentration of chitosan used is 0.01 to 10%, preferably 0.1 to 5%. Although the concentration of hinokitiol varies depending on the method of using the antibacterial solution, it may be 0.01% or more, and considering the concentration of the chitosan solution, it is preferably 0.02 to 0.1%. Further, the antibacterial metal salt is preferably selected from water-soluble salts. For example, the silver metal salt is silver nitrate, silver lactate, silver acetate, silver sulfate, silver perchlorate, and the like, and other metal salts may be the same water-soluble metal salts. The amount of the antibacterial metal salt added is 0.2 ppm or more based on the chitosan solution, which is an amount exhibiting antibacterial properties, and 100% based on the maximum amount of chitosan that can be contained in chitosan, and preferably a chitosan solution. To 1
Above ppm, 20% is better than chitosan.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION

The present invention will be described below in detail with reference to examples. Example 1 Chitosan 1 in 100 ml of 1% malonic acid solution
After dissolving g, add 800 ppm of hinokitiol and stir well. (Example 2) In 100 ml of water-soluble chitosan having a concentration of 4%,
Add 800 ppm of hinokitiol and stir well. (Example 3) After dissolving 0.2 g of chitosan in 100 ml of 0.5% L-malic acid solution, 1,000 ppm of hinokitiol
Add and stir well. Example 4 Chitosan 3 in 100 ml of 5% citric acid solution
After dissolving g, add 600 ppm of hinokitiol and stir well. (Example 5) After dissolving 3 g of chitosan in 100 ml of 0.3% malonic acid solution, 300 ppm of hinokitiol was added,
Further, add 0.55 g of silver lactate and stir well. Example 6 0.1 g of chitosan was dissolved in 100 ml of 1% L-glutamic acid solution, and then 100 ppm of hinokitiol was added.
And then add 0.03 g of silver nitrate and stir well. Example 7 Chitosan 5 in 100 ml of 3% citric acid solution
After dissolving g, 250 ppm of hinokitiol was added, and 1.55 g of silver acetate was added, and the mixture was stirred well. Example 8 Chitosan 2 in 100 ml of 1% malonic acid solution
After dissolving g, 200 ppm of hinokitiol was added, and 0.0001 g of silver sulfate was further added, followed by thorough stirring. (Example 9) 1 g of chitosan in 100 ml of 0.5% lactic acid solution
After dissolving the above, 300 ppm of hinokitiol is added, and 0.1 g of silver perchlorate is further added, followed by thorough stirring. Comparative Example 1 Chitosan was added to 100 ml of a 0.5% malonic acid solution.
Dissolve 0.3 g and stir well. (Comparative Example 2) 1,000 ppm of hinokitiol was dissolved in water and stirred well. (Comparative Example 3) 600 ppm of hinokitiol is dissolved in water and well stirred. Comparative Example 4 Chitosan 2 in 100 ml of 1% malonic acid solution
After dissolving g, 0.0001 g of silver sulfate was added and stirred well.

(Example 10) Deodorization test Each sample solution of Examples and Comparative Examples was put in a glass bottle, and the smell immediately after the lid was opened was checked by 20 testers to check the strength of the smell. Judgment was made according to the following criteria, and the result is shown in (1) of Table-1. No hinokitiol odor-Slight hinokitiol odor ± Strong hinokitiol odor +

Example 11 Discoloration Test After each sample of the example and the comparative example was attached to a cloth,
A color change test by exposure to light was carried out, and the test result after one week is shown in (2) of Table-1.

[0008]

[Table 1]

(Example 12) An antibacterial test was conducted and the result (M
Table 2 shows the IC value).

[0010]

[Table 2]

From the above test results, the addition of hinokitiol to the chitosan solution reduces the odor of hinokitiol,
It was observed that discoloration was prevented and the antibacterial activity was increased, and that the antibacterial activity was further increased by adding a metal salt.

[0012]

The antibacterial agent composition based on hinokitiol or chitosan to which hinokitiol and a metal salt are added is economical without causing quality problems in a wide range of fields for antibacterial and antifungal purposes. In addition, a product having excellent antibacterial activity and no odor of hinokitiol can be obtained.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A01N 65/00 A01N 65/00 A C08K 3/10 C08K 3/10 5/04 5/04 5 / 098 5/098

Claims (3)

[Claims] 1. An antibacterial agent composition containing chitosan and hinokitiol as main components. 2. An antibacterial composition comprising chitosan, hinokitiol and an antibacterial metal salt. 3. The antibacterial agent according to claim 2, wherein the antibacterial metal salt is at least one selected from the group consisting of silver nitrate, silver lactate, silver acetate, silver formate, and silver perchlorate. Composition.