JPH09136824A - Antiaging preparation for external use for skin, preparation for external use for skin capable of inhibiting cross-linking of collagen and antiultraviolet ray preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation for external use for skin capable of manifesting effects on the prevention of the aging of the skin and maintenance, etc., of the elasticity of the skin by using an extract from a specific plant having effects on the suppression of the cross-linking of collagen or further, as desired, using an ultraviolet ray protectant in combination. SOLUTION: This antiaging preparation for external use for skin is obtained by using an extract separated from a plant belonging to the genus Lavandula of the family Labiatae as an active ingredient. For example, the species lavandula, angustifolia, lavender and lavandin are cited as the plant belonging to the genus Lavandula of the family Labiatae. Among the plants, an extract derived from that of a floral part is preferably used. The blending ratio of the extract is preferably 0.0001-10.0wt.%, especially preferably 0.001-1.0wt.%, based on the whole preparation for external use for the skin and expressed in terms of a dry substance. Furthermore, 0.01-30wt.%, especially 0.1-20wt.% ultraviolet ray protectant (a long- wavelength ultraviolet ray protectant is especially preferred) is preferably blended in the system. 4-Methoxy-4-t-butyldibenzoylmethane, etc., are cited as the long-wavelength ultraviolet ray protectant.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an anti-aging skin external preparation for preventing skin aging, and mainly collagen for inhibiting collagen cross-linking in the dermis to maintain skin elasticity and prevent wrinkles and sagging. It belongs to the technical field relating to a cross-linking inhibitor external preparation for skin and an anti-ultraviolet external preparation for protecting the skin from the harmful effects of excessive ultraviolet rays in sunlight.

[0002]

2. Description of the Related Art It is known that the skin becomes thinner and its metabolism decreases with aging. As a cause of this skin aging, aging is an important factor from a macroscopic point of view, and the effects of dryness, oxidation, ultraviolet rays of sunlight, etc. are also considered as direct factors relating to skin aging.

Conventionally, various means have been adopted to prevent the above-mentioned aging of the skin. For example, a skin external preparation containing various moisturizers for preventing skin aging due to dryness, a skin external preparation containing antioxidants such as vitamin E for preventing skin aging due to oxidation, or UV exposure An external preparation for the skin, etc., containing an ultraviolet absorber for preventing skin aging has already been provided. However, these conventional means for preventing skin aging are all means focusing on factors that are related to skin aging as a result,
It cannot be denied that it is not possible to get out of the "coping therapy" area and to obtain a sufficient skin anti-aging effect. Therefore, there is a current need to establish a "radical therapy" means to stop the more direct phenomenon that progresses skin aging.

[0004]

As a more direct phenomenon of promoting skin aging, an increase in collagen crosslinks (hereinafter referred to as collagen crosslinks) in the dermis is known (Cutaneous AgingEdited by Albert M. Kligman a).
nd Yoshio Takasu University of Tokyo Pres, 263-27
4, 1988; Sugiyama T., Fujimoto D., Arai C. and H
asegawa M., Biomed Res 8, 349-351, 1987). That is, the various skin aging factors mentioned above, especially ultraviolet rays (especially,
With exposure to long-wavelength ultraviolet light (UVA) that easily reaches the dermis (for crosslinking of collagen by exposure to ultraviolet light, see “Fujimori E., FEBS Lett 235 (1-2), 98-102, 198).
8 ”), the proliferative activity of fibroblasts, which are the main cells in the dermis, and the synthesis / degradation function of collagen, etc. are reduced, and the turnover speed of this collagen, etc. is also slowed. It is presumed that these will undergo various modifications and denaturation, and the crosslinking of collagen in the skin will increase.

As this collagen crosslink increases,
The skin becomes less elastic, wrinkles and sagging increase, and the aging of the skin progresses. An object of the present invention is to establish a "root therapeutic" means for suppressing the progress of this collagen cross-linking, and to provide a skin external preparation that meets various industrial requirements including prevention of skin aging.

[0006]

The present inventor has conducted extensive studies in view of the above problems. As a result, the extract extracted from the Lamiaceae plant Lauandura has the effect of suppressing collagen cross-linking, by using these compounds as the active ingredient, or by combining these compounds with an ultraviolet protective agent, the active ingredient It was found that the above-mentioned problems can be solved by the following. That is, in the present application, the present inventor provides the following inventions.

The present invention provides an anti-aging skin external preparation characterized in that it comprises an extract extracted from a plant of the genus Lauandra in the Lamiaceae family as an active ingredient.

An anti-aging external preparation for skin according to claim 2, which comprises the extract extracted from the plant of the genus Lauandra of the Lamiaceae according to claim 1 and one or more UV protective agents. I will provide a.

The third aspect of the present invention provides the anti-aging skin external preparation according to the second aspect, wherein the ultraviolet protective agent contains at least one long-wavelength ultraviolet protective agent.

In Claim 4, the long-wavelength UV protector is a 4-methoxy- ^4' - tert -butyldibenzoylmethane, 2-hydroxy-4-methoxybenzophenone and / or 2-hydroxy-4-methoxybenzophenone derivative. The external preparation for anti-aging skin according to claim 3 is provided.

[0011] In claim 5, the extract extracted from a plant of the genus Lauandra, belonging to the Labiatae family, is contained in a range of 0.0001% by weight or more and 10.0% by weight or less of the total amount of the external preparation for skin. An anti-aging external preparation for skin according to any one of claims 1 to 4 is provided.

[0012] In claim 6, the extract extracted from a plant of the genus Lauandra, belonging to the Labiatae family, is contained in a range of 0.001% by weight or more and 1.0% by weight or less of the total skin external preparation in terms of dry matter. An anti-aging external preparation for skin according to any one of claims 1 to 4 is provided.

In claim 7, one or more kinds of UV protective agents are added in an amount of 0.01% by weight or more based on the total weight of the external preparation for skin.
The anti-aging skin external preparation according to any one of claims 2 to 6, characterized in that it is contained in an amount of 30% by weight or less.

In Claim 8, one or more kinds of ultraviolet protective agents are contained in the range of 0.1% by weight or more and 20% by weight or less of the total external preparation for skin. An anti-aging skin external preparation according to any one of claims 2 to 6 is provided.

[0015] In claim 9, the anti-aging skin external preparation is a collagen cross-linking inhibition external preparation for external use, and the anti-aging skin external preparation according to any one of claims 1 to 8 is provided. To do.

[0016] In the tenth aspect, the anti-aging skin external preparation is an anti-UV skin external preparation, and the anti-aging skin external preparation according to any one of claims 1 to 8 is provided. .

[0017]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below. The present anti-aging skin external preparation, the collagen cross-linking inhibition skin external preparation, and the anti-ultraviolet skin external preparation (hereinafter,
Unless otherwise specified, it is referred to as the external preparation for skin of the present invention) with an extract extracted from the genus Lauandura of the Lamiaceae family.

About 20 kinds of plants of the genus Lauandra are used in the present invention. Some examples thereof include Rawandura, Angustifolia, Lavender, Lauandra Angustifolia Pyreneika, Spike Lavender, Lavandin and the like. In the present invention, the origin of the extract of Lavandula plant belonging to Lamiaceae, which is contained in the external preparation for skin of the present invention as an active ingredient, is not particularly limited, and examples thereof include flowers, stems, fruits and seeds of Lauandura plant belonging to Lamiaceae described above. Extracts extracted from roots, whole plants, etc. can be incorporated into the external preparation for skin of the present invention. In addition, in the present invention, it is preferable to use an extract derived from the flower part extract of the plant of the genus Lauandura genus.

The method for extracting these extracts is not particularly limited, and examples thereof include hydrophilic organic solvents such as water and alcohol, mixed liquids of water and these hydrophilic organic solvents, glycerin and 1,3-. Polyhydric alcohols such as butylene glycol, a mixture of water and these polyhydric alcohols and the like are extracted and provided by a generally known method as a solvent for extraction. It can be used as an active ingredient.

By incorporating an extract extracted from these Lamiaceae plants of the Labiatae family into the skin external preparation of the present invention, it contributes greatly to the expression of the desired effect in the skin external preparation of the present invention through the action of suppressing collagen cross-linking. can do. That is, in the collagen cross-linking inhibitor external preparation for skin of the present invention, by suppressing the collagen cross-linking, it becomes possible to maintain the elasticity of the skin and prevent the formation of wrinkles and sagging, and to maintain a beautiful skin to that extent. It becomes possible to do.

In addition, the anti-ultraviolet skin external preparation of the present invention can suppress so-called photoaging due to collagen cross-linking due to exposure to long-wavelength ultraviolet rays, and the skin can be protected from the viewpoint of specific action of ultraviolet rays on the skin. It becomes possible to protect.

Furthermore, in the anti-aging skin external preparation of the present invention, by suppressing collagen cross-linking, the elasticity of the skin due to aging of the skin including not only the above-mentioned photoaging but also the suppression of the progress of aging due to aging. It is possible to prevent the deterioration of the skin and the occurrence of wrinkles and sagging.

The amount of the extract extracted from the plant of the genus Lauandura belonging to the Labiatae family in the external preparation for skin of the present invention is the purpose of the external preparation for skin of the present invention, the type or amount of other components to be added to the external preparation for skin of the present invention, etc. It should be changed appropriately according to the present invention, and should not be specified unconditionally.
It is mixed in the range of 001% by weight or more and 10.0% by weight or less. When the compounding amount of the extract extracted from the Lamiaceae plant of the Labiatae family in the external preparation for skin of the present invention is less than 0.0001% by weight of the entire external preparation for skin of the present invention in terms of dry matter, through the collagen crosslinking inhibitory action, It is difficult to exert desired effects in the external preparation for skin of the present invention, which is not preferable. Further, even if it is blended in an amount of more than 10.0% by weight of the total skin external preparation of the present invention in terms of dry matter, the above-mentioned respective effects corresponding to the increase in the blending amount are no longer observed, which is not preferable.

From the balance between the expression strength of each effect and the blending amount, the extract extracted from the plant of the genus Lauandura in the skin external preparation of the present invention is almost the entire skin external preparation of the present invention in terms of dry matter. It is preferable that the content is 0.001% by weight or more and 1.0% by weight or less.

The total amount of the external preparation for skin of the present invention of 0.
When the blending amount is about 0001% by weight or more and less than 0.001% by weight, the effect of suppressing collagen cross-linking is often not sufficient only by blending the extract extracted from Lavandula spp. However, it tends to be necessary to increase the amount of other auxiliary components and the like to be blended.

[0026] Further, when the amount of the dry agent is more than 1.0% by weight and not more than 10.0% by weight of the total external preparation for skin of the present invention, the extract extracted from the plant of the genus Lauandura genus is in the Lamiaceae family. The enhancement of the desired effect with respect to the increase of the blending amount becomes slow, and rather the active formulation of the other external ingredient tends to exert the excellent effect as a result of positive blending of other auxiliary components.

The external preparation for skin of the present invention may further contain an ultraviolet protective agent. Where "UV protectant"
The concept is a concept that includes both an "ultraviolet absorber" that is a substance that physically absorbs ultraviolet rays and an "ultraviolet blocking agent" that is a substance that scatters and reflects ultraviolet rays by a physical action.

By incorporating an ultraviolet protective agent into the external preparation for skin of the present invention, the desired effects in the external preparation for skin of the present invention can be synergistically exhibited. That is, in the collagen cross-linking inhibitor external preparation for skin of the present invention, the amount of ultraviolet rays that are very deeply involved in collagen cross-linking reaching the skin is reduced, collagen cross-linking is synergistically inhibited, and the skin elasticity is further maintained, and wrinkles are reduced. It is possible to prevent the occurrence of sagging, and as a result, it is possible to provide a collagen cross-linking inhibitor external preparation for skin that is capable of more effectively maintaining beautiful skin.

Further, it is needless to say that the crosslinking of collagen can be synergistically inhibited as described above by incorporating an ultraviolet protective agent into the anti-ultraviolet external preparation of the present invention to reduce the amount of ultraviolet light reaching the skin. However, it is possible to reduce various adverse effects on the living body by exposure to ultraviolet rays other than collagen crosslinking. In other words, by incorporating an ultraviolet protective agent and an extract extracted from the genus Lauandra from the Lamiaceae family as an active ingredient into the anti-ultraviolet external preparation of the present invention, the serious effect of collagen crosslinking, which is enhanced by ultraviolet exposure, is individually By suppressing the above, it is possible to provide an anti-ultraviolet skin external preparation that exhibits a superior anti-ultraviolet effect than an anti-ultraviolet skin external preparation containing an ultraviolet protective agent as an active ingredient alone.

Here, as an adverse effect on the living body due to exposure to ultraviolet rays, for example, in addition to the above-mentioned collagen crosslinking, "delayed blackening" mainly caused by medium wavelength ultraviolet rays; mainly caused by long wavelength ultraviolet rays. "Instant blackening";"Inactivation of enzyme activity" related to skin metabolism, etc .; D
Examples thereof include "promotion of skin cancer" caused by damage of NA; "short-term action of decreasing immune function" which causes the development of herpes simplex; "onset of photosensitivity". In the anti-ultraviolet skin external preparation of the present invention, the compounding amount and combination of the active ingredients can be appropriately determined according to each specific purpose.

By adding an ultraviolet protective agent to the anti-aging skin external preparation of the present invention, it becomes possible to more effectively suppress the collagen cross-linking which progresses steadily with skin aging, and in addition, it is possible to expose to ultraviolet rays. As a result, it becomes possible to suppress other effects that promote the aging of the skin, and an anti-aging external preparation for external use that more effectively suppresses the progress of the aging of the skin can be provided.

In the present invention, the type of UV protective agent that can be provided can be physicochemically incorporated into the external preparation for skin of the present invention, and the above synergistic effect can be exerted in the external preparation for skin of the present invention. Is not particularly limited as much as possible. Therefore, the UV protective agents will be listed below, but it goes without saying that the UV protective agents that can be incorporated into the external preparation for skin of the present invention are not limited to these UV protective agents.

That is, as a long wavelength ultraviolet (UVA) absorber, methylanthranilate, homomenthyl-N-
Anthranilic acid type UV absorbers such as acetylanthranilate; 2,4-dihydroxybenzophenone, 2, 2
^' -Dihydroxy-4-methoxybenzophenone, 2,
2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone,
2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2
-Ethylhexyl-4'-phenyl-benzophenone-
Benzophenone-based UV absorbers such as 2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone;
2, 2'-hydroxy-5-methylphenyl benzotriazole, 2- (2 ^'- hydroxy-5'-tert - octylphenyl) benzotriazole, 2- ^(2' - hydroxy-5'-methylphenyl) benzotriazole And a benzotriazole-based ultraviolet absorber, such as dianisoylmethane and 4-methoxy- ^4′ - tert -butyldibenzoylmethane (parsol A).

Among these long-wavelength ultraviolet absorbers, 4
-Methoxy- ^4' - tert -butyldibenzoylmethane,
2-Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone derivative, such as 2-hydroxy-4-methoxybenzophenone-5-sulfonate, is a long-wavelength ultraviolet absorber excellent in safety and efficacy. .

Further, as a medium wavelength ultraviolet (UVB) absorber, para-aminobenzoic acid (hereinafter referred to as PABA), P
ABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA
Ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N,
Benzoic acid-based UV absorbers such as N-dimethyl PABA amyl ester; dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, p. -Salicylic acid-based UV absorbers such as isopropanol phenyl salicylate; octyl cinnamate,
Ethyl-4-isopropyl cinnamate, methyl-2,
5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, Octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, octyl methoxycinnamate, 3,4,5-trimethoxycinnamate-3-methyl -4- [methylbis (tri Chirushirokishi) silyl] butyl, cinnamic acid UV absorbers such as p- dimethoxy cinnamate monoethyl ester; 3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene -d,
Camphor derivatives such as 1-camphor and 5- (3,3-dimethyl-2-norbornylidene) -3-penten-2-one; urocanic acid, urocanic acid ethyl ester,
2-phenyl-5-methylbenzoxazole, dibenzalazine, etc. can be mentioned.

Further, as an ultraviolet blocking agent, titanium oxide (TiO ₂ ), talc (MgSiO ₂ ), carmine (F)
eO ₂ ), bentonite, kaolin, zinc oxide (Zn)
O) and the like.

These UV protective agents can be incorporated in the skin external preparation of the present invention in an appropriate combination according to the specific purpose and dosage form of the skin external preparation of the present invention to be prepared. However, collagen cross-linking is known to be a phenomenon mainly in the dermal layer of the skin. Therefore, when a UV protective agent is incorporated in the external preparation for skin of the present invention for the purpose of directly exerting a synergistic effect on the inhibition of collagen cross-linking, it is easier to reach the dermis layer than the medium-wavelength UV (280 to 320 nm) absorber. Long-wavelength ultraviolet light (UVA: 3)
(20-400 nm) It is preferable to positively incorporate an absorber.

Particularly, in the collagen cross-linking inhibitor of the present invention, it is preferable to positively incorporate a long-wavelength ultraviolet absorber for the purpose of directly attempting a synergistic effect of inhibiting collagen cross-linking.

Here, the medium-wavelength ultraviolet absorber and the long-wavelength ultraviolet absorber do not necessarily mean that only the medium-wavelength ultraviolet ray or the long-wavelength ultraviolet ray can be absorbed, but at least the ultraviolet ray having the wavelength can be absorbed. It means that you can. For example, long wavelength ultraviolet (UVA: 3)
The benzophenone-based UV absorber mentioned as the absorber (20 to 400 nm) can absorb not only long-wavelength UV but also medium-wavelength UV.

The compounding amount of the UV protective agent can be appropriately changed depending on the properties to be imparted to the skin external preparation of the present invention, but is usually 0.01% by weight based on the whole skin external preparation of the present invention. As described above, the content is 30% by weight or less, preferably 0.1% by weight or more and 20% by weight or less. If the blending amount is less than 0.01% by weight with respect to the entire skin external preparation of the present invention, there is a tendency that the synergistic effect due to the blending of the ultraviolet protective agent is not sufficiently exhibited. Further, even if the amount exceeds 30% by weight of the total external preparation for skin of the present invention, the synergistic effect commensurate with the increase in the amount added tends not to be seen.

As described above, the external preparation for skin of the present invention containing the above-mentioned active ingredients can sufficiently exert its intended effects of inhibiting collagen cross-linking, removing adverse effects of exposure to ultraviolet rays, and suppressing skin aging. . However,
By blending other medicinal components as necessary, for the purpose of imparting the effect that the external skin preparation will generally exhibit, blending this other medicinal component in the skin external preparation of the present invention is It is possible within a range that does not impair the intended effect of the present invention.

For example, imparting a moisturizing effect is useful for the purpose of preventing aging due to dry skin. In this case, for example, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, hexylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxy. Moisturizers such as stearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adducts, Izayoba rose extract, Astragalus membranaceus extract, melilot extract, etc. It is possible to mix with the external preparation for skin of the present invention.

The application of a whitening effect is useful for the purpose of alleviating the adverse effects of ultraviolet rays on the skin. In this case, a whitening agent such as a placenta extract, glutathione, and Yukinoshita extract can be added to the external skin preparation of the present invention.

The addition of the anti-inflammatory effect is useful for the purpose of alleviating the adverse effects of ultraviolet rays on the skin, as in the above. In this case, an anti-inflammatory agent such as a glycyrrhizic acid derivative, a glycyrrhetinic acid derivative, a salicylic acid derivative, hinokitiol, zinc oxide, and allantoin can be added to the external skin preparation of the present invention.

Similarly, activators such as royal jelly, photosensitizer, cholesterol derivative, calf blood extract and the like; nonyl acid warenylamide, nicotine for the purpose of alleviating the adverse effects of ultraviolet rays on the skin and suppressing the aging of the skin. Acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharis tincture, ictamol, caffeine, tannic acid, α-borneol, nicotinic acid tocopherol, inositol hexanicotinate, cyclanderate, cinnarizine, tolazoline, acetylcholine , Verapamil, cepharanthin,
Blood circulation promoters such as γ-oryzanol; antiseborrheic agents such as sulfur and thiantol can be added to the external preparation for skin of the present invention.

In addition, for various purposes, oyster extract component, laurel extract component, shikon extract component, peony extract component, assembly extract component, birch extract component, sage extract component, loquat extract component, carrot extract component, aloe extract component, Mallow extract component, iris extract component, grape extract component, Yokuinin extract component, loofah extract component, lily extract component, saffron extract component, senkyu extract component, ginger extract component, Hypericum extract component, Ononis extract component, rosemary extract component, Garlic extract ingredient,
It is also possible to mix a pepper extract component, botanical extracts such as chimpi, touki etc. in the skin external preparation of the present invention.

Further, in order to further impart a unique effect of each vitamin, for example, an effect of suppressing skin aging, to the external preparation for skin of the present invention, vitamin A oils such as vitamin A oil, retinol and retinol acetate; riboflavin; riboflavin butyrate, vitamin B ₂ such as flavin adenine nucleotide; pyridoxine hydrochloride, vitamin B ₆ such as pyridoxine dioctanoate; L-ascorbic acid, L
-Vitamin C such as ascorbic acid dipalmitate, L-ascorbic acid-2-sodium sulfate, L-ascorbic acid phosphate, DL-α-tocopherol-L-ascorbic acid diester dipotassium
Pantothenic acids such as calcium pantothenate, D-pantoenyl alcohol, pantoenyl ethyl ether and acetyl pantothenyl ethyl ether; Vitamin Ds such as ergocalciferol and cholecalciferol;
Nicotinic acid, nicotinic acid amide, nicotinic acid benzyl, and other nicotinic acids; α-tocopherol, tocopherol acetate, nicotinic acid DL-α-tocopherol, succinate DL-α-tocopherol, and other vitamin Es; vitamin P, biotin, and other vitamins The above vitamins can be incorporated into the external preparation for skin of the present invention.

The above-mentioned medicinal components are not limited to the other medicinal components which can be incorporated into the external preparation for skin of the present invention. In addition, the medicinal effects corresponding to the other medicinal components listed above are not limited to the above. For example, vitamin Cs can be used as a whitening component and also as an antioxidant aid. Further, the other medicinal ingredients listed above may be blended alone in the external preparation for skin of the present invention, or two or more medicinal ingredients may be blended in an appropriate combination according to the purpose. .

INDUSTRIAL APPLICABILITY The present invention can be widely applied to cosmetics, pharmaceuticals, quasi-drugs and the like applied to the outer skin, and its dosage form is also an aqueous solution type, a solubilizing type, an emulsifying type, a powder type, an oil type. A wide variety of dosage forms such as liquid type, gel type, ointment type, aerosol type, water-oil two-layer type, water-oil-powder three-layer type can be adopted. That is, basic cosmetics can be widely applied to the above-mentioned various dosage forms in the form of facial cleanser, lotion, milky lotion, cream, gel, essence (cosmetic), pack mask and the like. Further, makeup cosmetics can be widely applied to forms such as foundations. Furthermore, if it is a medicine or a quasi-drug, it can be widely applied to various ointments and the like. And, in these dosage forms and forms,
The form that the external preparation for skin of the present invention can take is not limited.

In the external preparation for skin of the present invention, generally known base components are blended widely depending on the above-mentioned desired dosage form and form within the range in which the intended effect of the present invention is not impaired. You can

That is, avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern oil, castor oil, linseed oil. Oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Liquid fats and oils such as glycerin trioctanoate and glycerin triisopalmitate; cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel oil,
Solid fats and oils such as pork fat, beef bone fat, mokuro kernel oil, hydrogenated oil, beef leg oil, mokuro, hydrogenated castor oil; beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivotaro, whale wax, montan wax, nukarou, lanolin,
Kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin,
Shellac wax, POE lanolin alcohol ether, P
Waxes such as OE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether; oils such as liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, etc. Hydrocarbon oils; lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-
Hydroxystearic acid, undecylenic acid, tallic acid,
Isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DH
Higher fatty acids such as A); lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol,
Linear alcohols such as myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterols, hexyldecanol, isostearyl alcohol, octyldodecanol, etc. Branched alcohols such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate,
Hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearylate, ethylene glycol di-2-ethylhexylate. , Dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, tri-2-ethylhexyl trimethylolpropane, triisostearate tri Methylol propane, tetra-2-ethylhexyl pentane erythritol, tri-2-ethylhexyl glycerin, triisostearate Trimethylol propane, cetyl-2
Ethyl hexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol,
Acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-
Glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate,
Di-2-ethylhexyl sebacate, myristic acid 2-
Hexyldecyl, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, synthetic ester oils such as ethyl acetate, butyl acetate, amyl acetate, triethyl citrate; dimethylpolysiloxane, methyl Chain polysiloxanes such as phenylpolysiloxane and methylhydrogenpolysiloxane, cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane, and silicone resins that form a three-dimensional network structure. , Silicones such as silicone rubber; base for soap, fatty acid soap such as sodium laurate, sodium palmitate, etc., higher alkyl sulfate ester salt such as sodium lauryl sulfate, K lauryl sulfate, P E triethanolamine lauryl sulfate, alkyl ether sulfate salts such as POE sodium lauryl sulfate, sodium lauroyl sarcosinate, etc. N- acyl sarcosinates, N- myristoyl -N-
Methyl taurine sodium, coconut oil fatty acid methyl tauride sodium, lauryl methyl tauride sodium and other higher fatty acid amide sulfonates, POE oleyl ether phosphate sodium, POE stearyl ether phosphate and other phosphate ester salts, di-2-ethylhexyl Sodium sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sulfosuccinates such as sodium lauryl polypropylene glycol sulfosuccinate, sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonic acid, etc. Alkylbenzene sulfonate, N-
Monosodium lauroyl glutamate, disodium N-stearoyl glutamate, N-myristoyl-L
N-acyl glutamates such as monosodium glutamate, higher fatty acid ester sulfates such as hydrogenated coconut fatty acid sodium glycerin sulfate, sulfated oils such as funnel oil, POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate, sodium lauroyl monoethanolamide succinate, N-palmitoyl aspartate ditriethanolamine, sodium caseinate, etc. Anionic surfactants: alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium chloride Alkylpyridinium salts such as kilsilyldimethylammonium salt, poly (N, N'-dimethyl-3,5-methylenepiperidinium) chloride, cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, Cationic surfactants such as norinium salts, dialkyl morphonium salts, POE alkylamines, alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride and benzethonium chloride;
Imidazoline amphoteric interfaces such as 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imitazolinium hydroxide-1-carboxyethyloxy disodium salt Surfactants, amphoteric surfactants such as betaine-based surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetate betaine, alkylbetaine, amidobetaine and sulfobetaine; sorbitan; Monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate,
Sorbitan fatty acid esters such as sorbitan trioleate, diglycerol penta-2-ethylhexylate sorbitan, diglycerol sorbitan tetra-2-ethylhexylate, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α glycerin polyglycerin fatty acids such as glycerin pyroglutamate oleate, α'-oleate, glyceryl monostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ether, polyoxyethylene. Lipophilic nonionic surfactants such as methylpolysiloxane copolymer; PO
E sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, PO
POE sorbitan fatty acid esters such as E-sorbitan tetraoleate, POE sorbitan monolaurate, POE sorbitan monooleate, POE sorbitan pentaoleate, POE sorbitan monostearate, etc .; POE
POE glycerin fatty acid esters such as E-glycerin monostearate, POE-glycerin monoisostearate, POE-glycerin triisostearate;
POE fatty acid esters such as OE monooleate, POE distearate, POE monodioleate, ethylene glycol cysteate, POE lauryl ether,
POE oleyl ether, POE stearyl ether,
POE alkyl ethers such as POE behenyl ether, POE2-octyldodecyl ether, POE cholestanol ether, POE octyl phenyl ether,
POE alkyl phenyl ethers such as POE nonyl phenyl ether and POE dinonyl phenyl ether, pluronics such as bruronic, POE POP cetyl ether, POE POP 2-decyl tetradecyl ether, POE POP monobutyl ether, POE
-POH hydrogenated lanolin, POE / POP alkyl ethers such as POE / POP glycerin ether, tetra-POE / tetra-POP ethylenediamine condensates such as tetronic, POE castor oil, POE castor oil, POE
E-hardened castor oil monoisostearate, POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearate diester, PO
POE castor oil derivatives such as E-cured castor oil maleic acid, cured castor oil derivatives, POE beeswax lanolin derivatives such as POE sorbitol beeswax, coconut oil fatty acid diethanolamide, alkanolamides such as lauric acid monoethanolamide, fatty acid isopropanolamide, POE propylene glycol Fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, PO
E Nonylphenyl formaldehyde condensates, hydrophilic nonionic surfactants such as alkylethoxydimethylamine oxide, trioleylphosphoric acid, etc .; preservatives such as methylparaben, ethylparaben, butylparaben, etc .; sequestration of sodium edetate, EDTA, etc. Agents: High plant system such as araavia gum, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algae colloid (cassius extract), starch (rice, corn, potato, wheat), glycyrrhizic acid Natural water-soluble polymers such as molecules, microbial polymers such as xanthan gum, dextran, succinoglucan, and bullan, and animal polymers such as collagen, casein, albumin, and gelatin; Starch-based polymers such as dimethyl starch and methyl hydroxypropyl starch Methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose (CMC), crystalline cellulose, cellulose powder, etc. Semi-synthetic water-soluble polymers such as cellulosic polymers, sodium alginate, and alginic acid polymers such as propylene glycol alginate; polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer (carbopol), alkyl-modified carboxy Vinyl polymers such as vinyl polymers, polyethylene glycol 2000, 4000, 60 0 polyoxyethylene-based polymer, polyoxyethylene-polyoxypropylene copolymer copolymer-based polymer, sodium polyacrylate, polyethyl acrylate, polyacrylamide and other acrylic-based polymers, polyethyleneimine, cationic polymers, etc. Synthetic water-soluble polymer; bentonite,
Inorganic water-soluble polymers such as silicate A1Mg (veegum), laponite, hectorite, and silicic acid anhydride; gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein,
Dextrin, gelatin, sodium pectate, sodium alginate, methyl cellulose, ethyl cellulose, CMC, hydroxyethyl cellulose, hydroxypropyl cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethyl. Thickeners such as ammonium sulfate cellulose, xanthan gum, magnesium aluminum silicate, bentonite, hectorite; talc, carion, mica, sericite, muscovite, phlogopite, synthetic mica, phlogopite, biotite, lithia Mica, permiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salt, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate, (calculated gypsum), calcium phosphate , Fluorapatite, Hydroxyapatite, Ceramic powder, Metal soap (Zinc myristate, Calcium palmitate, Aluminum stearate), Inorganic powder such as boron nitride, Polyamide resin powder (Nylon powder), Polyethylene powder, Polymethylmethacrylate powder, Powder components such as polystyrene powder, styrene / acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder and other organic powders; titanium dioxide, nitrous oxide Inorganic white pigments such as iron oxide (red iron oxide), iron titanate and other inorganic red pigments, γ-iron oxide and other inorganic brown pigments, yellow iron oxide, yellow clay and other inorganic yellow pigments black iron oxide, carbon black , Inorganic black pigments such as low order titanium oxide, inorganic purple pigments such as mango violet and cobalt violet, inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate, inorganic blue pigments such as ultramarine blue and navy blue. , Titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, metal powder pigments such as aluminum powder, copper powder, red 201, Red No. 202, Red No. 204, Red No. 205
No., Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow 205
No., Yellow No. 401, Blue No. 404 and other organic pigments, Red No. 3, Red No. 104, Red No. 106, Red No. 227,
Red 230, Red 401, Red 505, Orange 20
No. 5, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203
No. 3, Green No. 3, Blue No. 1, etc., organic pigments such as zirconium, barium or aluminum lake, chlorophyll,
Natural pigments such as β-caroline and the like, coloring agents such as titanium yellow, cursamine, safflower red and the like; and fragrances, water, alcohols and the like can be appropriately incorporated into the external preparation for skin of the present invention as necessary. The specific formulation of the external preparation for skin of the present invention will be described in Examples described later.

[0052]

EXAMPLES Next, the present invention will be described more specifically by way of examples. However, this does not limit the technical scope of the present invention. [Test Example] Effect of Preventing Collagen Crosslinking by Ultraviolet Rays (1) First, a method for obtaining the ratio of collagen crosslinkage by ultraviolet rays will be described. Collagen was extracted from human placenta by pepsin treatment and purified by salting out (Nishihara T. and Miyata T., Collagen Synposium.
3 , 66-93, 1962). And electrophoresis (Hayahi T. a
nd Nagai Y., J Biochem, 86 ( 2), 453-459, 1962
), The purity of this collagen was measured to be 94%.
Met. Next, the extracted and purified collagen (final concentration: 1 mg / ml) was kept at 37 ° C. in a phosphate buffer of pH 7.4 to form collagen fibers, and various samples described later were allowed to coexist with collagen. Irradiation with ultraviolet rays (TOSHIBA FL20S / BLB lamp, UVA region, peak 365 nm) having an energy of 0.0 J / cm ² (UVA intensity: 1.4).
mW / cm ² , irradiation time: 90 minutes). The collagen after irradiation was analyzed by an electrophoresis method and a densitometer (fluorescent densitometer F-808 manufactured by Cosmo Co., Ltd.), and the proportion of collagen crosslinked by the above-mentioned ultraviolet irradiation was measured.

Then, the inhibition rate of collagen cross-linking by the addition of various samples described below was calculated from the following equation.

(Equation 1)

(2) Next, Table 1 shows the test results for examining the collagen crosslink formation inhibitory action of lavender extract, which is one embodiment of the extract extracted from the plant of the genus Lauandra, belonging to the Lamiaceae family. All% in the table mean% by weight (excluding the inhibition rate).

[0055]

[Table 1]

From the results shown in Table 1, it was revealed that the coexistence of the lavender extract with collagen markedly suppressed the formation of collagen cross-links, which is extremely deeply related to skin aging, as described above. That is, this lavender extract is the above-mentioned anti-aging skin external preparation of the present invention,
It was revealed that they are extremely useful as active ingredients for the collagen cross-linking inhibitor external preparation for skin and the anti-UV external preparation for skin of the present invention.

In order to reliably achieve a collagen crosslink formation inhibition rate of 50% or more by adding the lavender extract, 0.000 of the total amount of the test system components in terms of dry matter was calculated.
Test Example 7 revealed that it was necessary to add 1% by weight or more of the lavender extract to the system.

Furthermore, if the amount of lavender extract added to the system is less than 0.0001% by weight of the total amount of test system components in terms of dry matter, it will be difficult to effectively suppress collagen crosslinking. Example 8 revealed. Conversely, if the amount of lavender extract added to the system exceeds 10.0% by weight of the total test system components in terms of dry matter, further inhibition of collagen cross-link formation will be achieved even with additional addition. It was also revealed in Test Example 1 that the above cannot be expected.

(3) Examination of Synergistic Effect by Combined Use with Ultraviolet Absorber Sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, which is one of long-wavelength ultraviolet (UVA) absorbers, is used as the lavender. Table 2 shows the test results for examining the synergistic effect on the collagen cross-linking inhibitory effect when used in combination with the extract. In addition,% in the table
All mean% by weight (excluding the inhibition rate).

[0060]

[Table 2]

According to Table 2, a test system in which sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, which is one of long-wavelength ultraviolet (UVA) absorbers, and lavender extract described above were added together. It was revealed that a synergistic effect on the inhibition of collagen cross-linking formation was observed. Ie, this lavender extract and 2
-Hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt is used as an active ingredient in combination with the anti-aging skin external preparation of the present invention, the collagen cross-linking inhibitor external preparation for external use and the anti-UV skin external preparation of the present invention. It became clear that it is a very useful prescription for a drug.

In the present system in which 0.1% by weight of the lavender extract was added to the whole test system components, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate was added in an amount of 0.1% by weight or more. , 20.0% by weight
It became clear that it was necessary to add: That is, when the amount of sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate added was less than 0.01% by weight of the whole test system components, a synergistic effect with the lavender extract was hardly observed (Test Example 17). And Test Example 18), conversely, the synergistic effect of the collagen cross-linking inhibitory effect was not improved even if the content was more than 30% by weight (Test Example 9 and Test Example 10).

By the way, in this test example, the ultraviolet absorber is one of long-wavelength ultraviolet (UVA) absorbers, 2
-Hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt is used, but this UV absorber mainly inhibits the long-wavelength UV light from reaching the collagen, so that the synergistic effect shown in Table 2 is obtained. It is highly estimated that it will be demonstrated. In view of this, since other ultraviolet absorbers, particularly collagen in the living body, are mainly present in the dermis rather than the epidermis, by incorporating the long-wavelength ultraviolet absorber in the external preparation for skin of the present invention, a similar synergistic effect can be obtained. It is clear that it will be demonstrated.

(3) Examination of Synergistic Effect when Each Active Ingredient is Combined and Combined With the above-mentioned lavender extract, the above-mentioned 2-hydroxy-4 is added.
In addition to sodium methoxybenzophenone-5-sulfonate, Table 3 shows the test results of the case where octyl methoxycinnamate which is a medium wavelength ultraviolet (UVB) absorber was added in combination to the test system. All% in the table mean% by weight (excluding the inhibition rate).

[0065]

[Table 3]

According to Test Example 22, when two kinds of ultraviolet absorbers were further combined with the lavender extract,
It was revealed that the inhibition of collagen cross-linking can be performed most efficiently.

Hereinafter, examples of blending the external preparation for skin of the present invention in various dosage forms will be described as examples. In addition, each external preparation for skin exhibited excellent anti-aging effect, collagen cross-linking inhibitory effect and anti-ultraviolet effect.

[Example 1] Skin toner% by weight (1) Lavender extract 0.05 (2) 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt 0.1 (3) Tocopherol acetate 0.01 ( 4) glycerin 4.0 (5) 1,3-butylene glycol 4.0 (6) ethanol 8.0 (7) polyoxyethylene (60) hydrogenated castor oil 0.5 (8) methylparaben 0.2 (9) Citric acid 0.05 (10) Sodium citrate 0.1 (11) Perfume 0.05 (12) Purified water Residual

<Production Method> Lavender extract (1), sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate (2), citric acid (9), sodium citrate (10), and purified water (12) were added. Glycerin (4),
The 1,3-butylene glycol (5) was dissolved. Separately, polyoxyethylene (60) hydrogenated castor oil (7), tocopherol acetate (3), perfume (11), and methylparaben (8) were dissolved in ethanol and added to the above-mentioned purified aqueous solution to solubilize and filter. To obtain the desired lotion.

Example 2 Cream Weight% (1) Cetostearyl Alcohol 3.5 (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced Lanolin 5.0 (5) Ethylparaben 0.3 (6) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) stearic monoglyceride 2.0 (8) sodium N-stearoyl glutamate 0.5 (9) 4-methoxy- ^4' - tert -butyl Dibenzoylmethane 1.0 (10) Octyl methoxycinnamate 10.0 (11) Retinol acetate 2.0 (12) Evening primrose oil 0.05 (13) Perfume 0.03 (14) Lauandra extract 0.1 ( 15) 1,3-Butylene glycol 5.0 (16) Polyethylene glycol 1500 5.0 (17) Purified water Residual

<Production Method> Cetostearyl alcohol (1), squalane (2), beeswax (3), reduced lanolin (4), ethylparaben (5), polyoxyethylene (20) sorbitan monopalmitate (6), Stearic acid monoglyceride (7), sodium N-stearoyl glutamate (8), 4-methoxy- ^4' - tert -butyldibenzoylmethane (9), octyl methoxycinnamate (10), retinol acetate (1)
1), evening primrose oil (12) and fragrance (13) are dissolved by heating (oil phase), and purified water (17) is used to extract Lauandura extract (1).
4) 1,3-butylene glycol (15) and polyethylene glycol 1500 (16) were dissolved and kept at 70 ° C (aqueous phase). Then, the oil phase was added to this aqueous phase while stirring. Then, the mixture was treated with a homomixer to make the emulsified particles fine, and then rapidly cooled with stirring to obtain a desired cream.

Example 3 Emulsion weight% (1) 2-Ethylhexyl paradimethylaminobenzoate 0.1 (2) Mono-2-ethylhexyl diparamethoxycinnamic acid 0.2 (3) Stearic acid 1.5 (4) Cetyl alcohol 0.5 (5) Beeswax 2.0 (6) Polyoxyethylene (10) Monooleate 2.0 (7) L-arginine 0.3 (8) L-sodium glutamate 0.02 (9) PCA-Na 0.05 (10) Spike lavender extract 0.2 (11) Angustifolia extract 0.01 (12) Propylene glycol 5.0 (13) Glycerin 3.0 (14) Ethanol 3.0 (15) Ethylparaben 0.3 (16) Perfume 0.03 (17) Carboxyvinyl polymer 0.12 (18) Purified water Residual

<Production Method> Spike lavender extract (10), angustifolia extract (11), L-arginine (7), sodium L-glutamate (8), PCA-Na (9) in purified water (18). ), Propylene glycol (12), glycerin (13), ethanol (1
4) and carboxyvinyl polymer (17) were added and dissolved by heating and kept at 70 ° C (aqueous phase). Next, other components were mixed, dissolved by heating, and kept at 70 ° C. (oil phase). Then, this oil phase was added to the aqueous phase for preliminary emulsification, and the mixture was uniformly emulsified with a homomixer. Then, it was rapidly cooled with stirring to obtain a desired emulsion.

Example 4 Foam Mask Weight% (1) Lavandin Extract 1.0 (2) 2-Hydroxy-4-methoxybenzophenone 0.1 (3) Stearic Acid 1.0 (4) Behenic Acid 1. 0 (5) Self-emulsifying glyceryl monostearate 1.5 (6) Polyoxyethylene monostearate (5) Glycerin 2.5 (7) Batyl alcohol 1.5 (8) Perfume 0.05 (9) Glycerin 5 0.0 (10) 1,3-butylene glycol 5.0 (11) Polyethylene glycol 1500 3.0 (12) Methylparaben 0.1 (13) Potassium hydroxide 0.15 (14) Purified water Residual (15) Liquefied petroleum Gas 6.0 (16) Dimethyl ether 2.0

<Production Method> Lavandin extract (1), glycerin (9), 1,3-butylene glycol (10) and polyethylene glycol 1500 (1) in purified water (14).
1), methylparaben (12), potassium hydroxide (1
3) was added and dissolved by heating at 70 ° C. (aqueous phase). Next, other components were mixed, heated and dissolved, and then maintained at 70 ° C. (oil phase). This oil phase was added to the above aqueous phase, and the mixture was uniformly mixed and cooled. Then, this uniformly mixed mixture was filled in a container. Finally, liquefied gas and dimethyl ether were added as propellants to obtain the desired foam mask.

Example 5 Ointment wt% (1) Angustifolia pyrenica extract 0.1 (2) Lavender extract 10.0 (3) 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt 0.5 (4) Octyl paradimethylaminobenzoate 4.0 (5) Butylmethoxybenzoylmethane 1.0 (6) Tocopherol acetate 0.5 (7) Retinol palmitate 1.0 (8) Stearyl alcohol 18.0 (9) Mokurou 20.0 (10) Polyoxyethylene (10) Monooleate 0.25 (11) Glycerin monostearate 0.3 (12) Vaseline 32.0 (13) Purified water Residue

<Production Method> Angustifolia pyrenica extract (1), lavender extract (2) and sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate (3) were dissolved in purified water (13). It was kept at 70 ° C (aqueous phase). Then, other components were mixed and dissolved at 70 ° C. (oil phase). This oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain a desired ointment.

Example 6 Sunscreen Emulsion Weight% (1) Stearic Acid 2.0 (2) Cetyl Alcohol 0.5 (3) Liquid Paraffin 10.0 (4) Polyoxyethylene (10) Oleate 1 .0 (5) sorbitan trioleate 1.0 (6) 2-hydroxy-4-methoxybenzophenone 3.0 (7) 2,2'-hydroxy-5-methylphenylbenzotriazole 1.0 (8) glyceryl mono- 2-Ethylhexanoyl-diparamethoxycinnamate 1.0 (9) Octyl methoxycinnamate 7.0 (10) Ethylparaben 0.3 (11) Perfume 0.2 (12) 1,3-Butylene glycol 5 0.0 (13) Dipropylene glycol 3.0 (14) Angustifolia extract 0.0001 (15) Lavandin extract 1.0 (16) Carboxyvinyl polymer 0.15 (17) Trisodium edetate 0.05 (18) Triethanolamine 0.4 (19) Silica 2.0 (20) Talc 2.0 (21) Titanium oxide 3.0 (22) Zinc oxide 3.0 (23) Purified water Residual

<Production Method> 1,3-butylene glycol (12) to triethanolamine (18) in purified water (23).
After the above component was added and dissolved, silica (19) to zinc oxide (22) were dispersed and kept at 70 ° C (aqueous phase). On the other hand, stearic acid (1) to fragrance (11) were heated, mixed and dissolved, and added to this aqueous phase. After the addition, this was uniformly emulsified with a homomixer and then rapidly cooled with stirring to obtain a desired sunscreen emulsion.

Example 7 Sunblock Cream Weight% (1) Decamethylcyclopentasiloxane 30.0 (2) Liquid Paraffin 5.0 (3) Polyoxyalkylene Modified Organopolysiloxane 1.5 (4) Distearyl Dimethylammonium chloride 0.6 (5) Octyl methoxycinnamate 12.0 (6) 4- tert -butyl-4′-methoxydibenzoylmethane 0.1 (7) Glyceryl mono-2-ethylhexanoyl-dipara Methoxycinnamate 0.1 (8) Ethylparaben 0.2 (9) Perfume 0.3 (10) Titanium oxide 10.0 (11) Zinc oxide 5.0 (12) Talc 2.0 (13) Glycerin 5. 0 (14) Rauandula angustifolia extract 0.5 (15) Spike lavender extract 0.1 (16 Smecton 1.0 (17) Purified water Balance

<Production Method> Decamethylcyclopentasiloxane (1) to fragrance (9) were heated and mixed at 70 ° C. to dissolve them (oil phase). Next, titanium oxide (10) to talc (12) were added to this oil phase, and this was dispersed and mixed with a disper. On the other hand, glycerin (13) to smecton (16) were mixed with purified water (17) and dissolved / dispersed to maintain 70 ° C. (aqueous phase), which was gradually added to the oil phase while stirring with a disper. . This was stirred sufficiently uniformly and then cooled to obtain the desired sunscreen cream.

[0082]

According to the present invention, an anti-aging skin external preparation for preventing skin aging (claims 1 to 8), which mainly inhibits collagen cross-linking in the dermis to maintain skin elasticity,
A collagen cross-linking inhibitor external preparation for skin (claim 9) that prevents wrinkles and sagging, and an anti-ultraviolet external skin preparation (claim 10) that protects the skin from the adverse effects of excessive ultraviolet rays in sunlight.

Continuation of front page (51) Int.Cl. ⁶ Identification code Office reference number FI Technical display area A61K 35/78 ADT A61K 35/78 ADTQ

Claims (10)

[Claims] 1. An anti-aging external preparation for skin, which comprises an extract extracted from a plant of the genus Lauandura of the Lamiaceae family as an active ingredient. 2. An external anti-aging skin preparation comprising an extract extracted from the plant of the genus Lauandura of the Lamiaceae according to claim 1 and one or more UV protective agents. 3. The anti-aging skin external preparation according to claim 2, wherein the UV protective agent contains at least one kind of long-wavelength UV protective agent. 4. A long-wavelength ultraviolet protective agent is 4-methoxy-4.
^'- tert - butyl dibenzoylmethane, anti-aging external preparation for skin according to claim 3, characterized in that the 2-hydroxy-4-methoxybenzophenone and / or 2-hydroxy-4-methoxybenzophenone derivatives. 5. An extract extracted from a plant of the genus Lauandra, belonging to the Labiatae family, is added to 0.000 of the total amount of the skin external preparation as a dry matter.
The anti-aging skin external preparation according to any one of claims 1 to 4, which is contained in a range of 1% by weight or more and 10.0% by weight or less. 6. An extract extracted from a plant of the genus Lauandra, belonging to the Labiatae family, in an amount of 0.001 of the total amount of the skin external preparation as a dry matter.
The anti-aging skin external preparation according to any one of claims 1 to 4, wherein the external anti-aging agent is contained in the range of 1% by weight or more and 1.0% by weight or less. 7. The method according to claim 2, wherein the UV protective agent is contained in an amount of 0.01% by weight or more and 30% by weight or less based on the total weight of the external preparation for skin. Item 7. The external anti-aging agent for skin according to any one of items 6. 8. The method according to claim 2, wherein the UV protective agent is contained in an amount of 0.1% by weight or more and 20% by weight or less based on the whole skin external preparation. Item 6
The anti-aging skin external preparation according to any one of claims 1 to 4. 9. The external anti-aging agent for skin is a collagen cross-linking inhibitor external agent for skin.
The anti-aging skin external preparation according to any one of claims 1 to 4. 10. The external preparation for anti-aging skin according to any one of claims 1 to 8, wherein the external preparation for anti-aging skin is an external preparation for anti-aging skin.