JPH09103275A - Tablet confection containing galenical extract-compounded microcapsule - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject tablet containing a galenical extract whose medicinal effect can be expected, excellent in portability, capable of being always eaten, useful for maintaining health, and good in flavor by adding galenical extract-compounded microcapsules to a food raw material and subsequently tableting the mixture. SOLUTION: Panax ginseng extract, Ginko biloba leaf extract, Crataegus cuneata extract, Glycyrrhiza glabra extract, Euphoria longana extract, etc., as a galenical extract is mixed with gelatin, xanthane gum, locust bean gum, etc., in water. The mixture is further mixed with sugar, etc., and dissolved at 70 deg.C. The solution is transferred to a particle-forming tower with a metering pump, and sprayed in air from the overhead of the tower with a rotary disk type atomizer to produce 700-1000μm liquid drops, which are cooled to a material temperature. The solidified products are dried to obtain the galenical extract-containing microcapsules. The microcapsules are mixed with a food raw material and subsequently tableted to obtain the objective tablets excellent in portability, capable of being always eaten, and useful as a health food, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a tablet confectionery containing a microcapsule containing a crude drug extract and having a good flavor.

[0002]

2. Description of the Related Art Conventionally, various kinds of drinks containing various crude drugs, their extracts and vitamins and pursuing nourishing tonic and recovery from fatigue have been commercially available. However, it is difficult to take these drinks easily because they are beverages (liquids) during a tired meeting or while traveling on a commuter train. In addition, it is inferior in portability, and it is inevitable that it will be difficult to drink unless it is cooled, which makes it difficult to drink. In addition, although a medicinal herb extract mixed in a microcapsule is commercially available due to its simplicity, it is expected to prevent bad breath and feel refreshed, and is not expected to be delicious as a food. A tablet confection containing a crude drug extract that is expected to have a medicinal effect, excellent portability, and a flavor that can be eaten at any time has not yet been marketed.

[0003]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a tablet confection containing a herbal medicine extract, which is expected to have a medicinal effect, as a microcapsule, which has excellent portability and can be eaten at any time. To do.

[0004]

The above objects of the present invention are as follows.
1. 1. Tablet confectionery containing microcapsules containing a crude drug extract. 2. The tablet confectionery according to claim 1, wherein the microcapsule content in the tablet confectionery is 2 to 30% by weight. The content of the crude drug extract in the microcapsules is 2 to 75% by weight.
Alternatively, it is achieved by the tablet confectionery described in 2.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Generally, many herbal extracts have unique odors and bitterness, and even those which are said to have various medicinal effects, the odors and bitterness are likely to remain in the final product, so that they are used as food ingredients. The use of may be restricted.

[0006] For example, ginkgo biloba extract is said to be effective in the prevention and treatment of hypertension, arteriosclerosis, senile dementia and the like, and has been used for a long time to maintain health in Europe and has been used as a drug in Germany. . Ginkgo biloba extract has a strong bitterness because it contains a large amount of flavone glycosides and terpenes, which limits its application to foods.

Similarly, valerian camphor has an excellent sedative effect, but it is difficult to apply it to foods because of its strong peculiar odor.

In order to improve such bitterness and odor,
It is possible to enclose a crude drug extract in microcapsules, but the improvement of odor is not sufficient with just this processing, and even if a sweetener or an acidulant is blended, it is aimed to improve bitterness. The taste is not good enough.

Therefore, the present inventors have found that the taste is remarkably corrected by tableting the microcapsules containing the crude drug extract together with other food materials to form a tablet confectionery, and thus the present invention has been accomplished.

The food materials to be tabletted together with the microcapsule containing crude drug extract used in the present invention are sugar, lactose, starch syrup, reduced starch syrup, glucose, sorbitol, maltitol, palatinose, erythritol, mannitol, lactitol, trehalose, trehalulose, Examples thereof include xylitol, starch, and cellulose, which may be used alone or in combination of two or more, but are not limited thereto.

The crude drug extract used in the present invention includes:
Panax ginseng, eleuthero, pearl millet, kokushi, ginkgo, mugwort, longan garlic, licorice, prince,
Examples thereof include, but are not limited to, one or a combination of two or more selected from hawthorn nin, taisan, hawthorn, valerian, princese, chamomile, guarana, deer, hawthorn.

The microcapsule content contained in the tablet confectionery in the present invention is 2 to 30% by weight, preferably 5 to 15% by weight. If it is more than 30% by weight, the confectionery becomes brittle and unsuitable as a product. If it is less than 2% by weight, no medicinal effect can be expected.

The content of the crude drug extract in the microcapsules contained in the tablet confectionery of the present invention is 2 to 75% by weight.
If it exceeds 5% by weight, it is difficult to produce good microcapsules, and if it is less than 2% by weight, it is necessary to put a large amount of microcapsules in the tablet confection, and the tablet confection tends to become brittle. It is also disadvantageous in terms of product cost.

In addition, flavors, pigments, lubricants and the like generally added to tablet confectionery can be used in the present invention, and fruit juice or the like may be added for the purpose of seasoning. Further, the present invention may be combined with an oligosaccharide, various vitamins, minerals and the like to prepare a tablet confection.

Next, the microcapsules will be described. Microencapsulation methods generally include (1) chemical techniques, (2) physicochemical techniques, (3) physical techniques,
(4) Others, etc. Among them, chemical techniques include interfacial polymerization and in-liquid curing coating, and physicochemical techniques include separation from aqueous systems, phase separation from organic solvent systems, and in-liquid drying. The physical technique is classified into an air suspension coating method, a vacuum vapor deposition coating method, a spray drying method and the like.

Among them, the microcapsule production method using an edible gelling agent such as gelatin is a combination method such as in-liquid hardening method applying the gelling temperature, spray drying method with gel solution, powder bed method, etc. There is.

The following techniques can be mentioned as preferred embodiments of the microcapsules used in the present invention. That is, after spraying and atomizing a paste solution containing an edible gelling agent such as gelatin, the product temperature is lowered from the gelation point to the freezing point in a cooling atmosphere, and after collection and low-temperature drying, excellent surface gloss is obtained. Microcapsules with good stability and taste can be easily obtained.

The microcapsules used in the present invention are preferably granular substances wrapped with an edible gelling agent. Further, the edible gelling agent referred to in the present invention includes polysaccharides and proteins having a high molecular structure, for example, pectin, agar, carrageenan, gellan gum, furceleran, alginic acid, gelatin,
Examples thereof include enzyme-decomposed lecithin and casein, but the types thereof are not limited at all.

The powder bed method referred to in the present invention means that a paste solution containing an edible gelling agent is atomized and sprayed and then collected during powdering to prevent the particles from adhering and agglomerating, and then being separated into microcapsules. Is the way to get.

The spray drying method in the present invention is a commonly used drying method and is a method in which a paste solution containing an edible gelling agent is atomized and sprayed in hot air and the particles are dried to obtain microcapsules. .

The submerged curing method referred to in the present invention is a method of obtaining microcapsules by collecting and curing fine particles of a paste liquid containing an edible gelling agent in a dispersion medium such as oil and fat, and then separating and removing the dispersion medium. is there. Further, the in-liquid agitation hardening method is a method in which a paste solution containing an edible gelling agent is poured into a dispersion medium, stirred and dispersed to be finely divided and hardened, and then the dispersion medium is separated and removed to obtain microcapsules.

The term "drying" as used in the present invention means a method in which cold air below the gelling temperature of the collected microcapsules is aerated to dry the air. The drying device is not limited to the fluidized drying device, although the temperature is maintained below the oxidization temperature.

The temperature range referred to in the present invention is an ambient temperature above the gelation temperature of the target substance, and the cold region is an ambient temperature below the gelation temperature. To provide this atmosphere in the tower, a warm air generator is provided at the top of the tower, a cool air generator is provided at the bottom of the tower, and an exhaust hole is provided at the side surface of the tower. It becomes a cold area.

[0024]

EXAMPLES Examples will be shown below, but the present invention is not limited to these examples.

Example 1 Table 1 Formulation of microcapsules Gelatin 490 g Xanthan gum 5 g Locust bean gum 5 g Sugar 250 g Panax ginseng extract 50 g Ginkgo biloba extract 20 g Hawthorn extract 50 g Licorice extract 80 g Longan garlic extract 50 g Water 1500 g In the mixing ratio shown in Table 1, 70 After dissolution at ℃, this solution was sent to the atomization tower by a metering pump, and sprayed into the air from the top of the tower by a rotary disk atomizer to 700-100
A droplet of 0 μm is generated, and the product temperature is 0 ° C while the droplet is falling.
Cool to solidify. The cooled particles were collected and dried by a fluidized drying device to obtain 800 g of microcapsule containing crude drug extract.

Table 2 Formulation of Test Group 1 Powdered sugar 50 g Glucose 38 g Crude drug capsule (Table 1) 10 g Powdered flavor 1 g Lubricating agent 1 g Table 3 Control group 1 combination Powdered sugar 52.5 g Glucose 38 g Panax ginseng extract 500 mg Ginkgo biloba extract 200 mg Hawthorn extract 500 mg Licorice extract 800 mg Longan garlic 500 mg Gelatin 5 g Powdered fragrance 1 g Lubricants 1 g Table 2 Test section 1 and Table 3 Control section 1 tableted using a tableting machine And The obtained product was eaten by 20 panelists and evaluated according to Table 4. Table 5 shows the results.

[0027]

[Table 4]

[0028]

[Table 5] Example 2 Table 6 Formulation of microcapsules Gelatin 430 g Gellan gum 10 g Xanthan gum 10 g Stevia 50 g Citric acid 50 g Eleuthero extract 50 g Thai soybean extract 80 g Kukoshi extract 80 g Ginseng extract 80 g Panax ginseng extract 80 g Vitamin B ₁ 6 g Vitamin B _{6 A} 10 g vitamin B ₂ 10 g Vitamin B ₂ 10 g 1,500 g of water By the same procedure as in the production of microcapsules of Example 1, 820 g of microcapsules containing crude drug and vitamins were obtained.

Table 7 Formulation of test group 2 Sorbitol 80 g Erythritol 13 g Crude drug / vitamin capsule (Table 6) 5 g Powdered flavor 1 g Lubricating agent 1 g Table 8 Formulation 2 of control group 2 Sorbitol 80 g Erythritol 13 g Eleuthero extract 250 mg Thai soybean extract 400 mg Ginger extract 400 mg 400 mg Panax ginseng extract 400 mg Vitamin B ₁ 30 mg Vitamin B ₂ 50 mg Vitamin B ₆ 50 mg Niacin 170 mg Caffeine 100 mg Stevia 250 mg Citric acid 250 mg Gelatin 2.25 g Powdered fragrance 1 g Lubricants 1 g Control group 2 in Table 7 and Table 8 The composition (parts by weight) shown in Table 1 was tableted using a tableting machine to give a product. The obtained product was eaten by 18 panelists and evaluated according to Table 4. Table 9 shows the results.

[0030]

[Table 9] The tablet confectionery obtained in Example 2 was divided into two groups of 18 panelists and fed 10 g (1 g × 10 pieces) daily for 7 days, and then interviewed for the following symptoms. The degree of improvement was evaluated by the test subjects as shown in Table 10, and the effect of improving symptoms such as fatigue was evaluated based on the average score.

(Amelioration of symptoms) (a) Fatigue, (b) shortness of breath, (c) headache, (d)
Energy enhancement, (e) stiffness, (f) eye fatigue, (g) irritability, (h) tinnitus, (i) appetite, (j) numbness,
(K) complexion, (l) dizziness, (m) insomnia

[0032]

[Table 10] The results of the above interviews are summarized in Table 11. It was demonstrated that the test section 2 of the microcapsule-containing tablet confectionery of Example 2 according to the present invention has an effect of improving symptoms such as fatigue like the control section 2 in which the crude drug extract was directly blended.

[0033]

[Table 11]

[0034]

As described above, the present invention has succeeded in developing a tablet confectionery containing microcapsules containing a crude drug extract, having a good flavor and a desired effect.

Claims (3)

[Claims] 1. A tablet confectionery containing microcapsules containing a crude drug extract. 2. The content of microcapsules in the tablet confectionery is 2 to 30.
The tablet confectionery according to claim 1, which is a weight%. 3. The tablet confectionery according to claim 1 or 2, wherein the content of the crude drug extract in the microcapsules is 2 to 75% by weight.