JPH0881307A - Noxious insect repellent - Google Patents

Abstract

PURPOSE: To obtain a noxious insect repellent excellent in initial activity and also in durability. CONSTITUTION: This noxious insect repellent contains a carane-3,4-diol (e.g. 1S,3S,4S,6R-carane-3,4-diol) and a silicone oil having a viscosity of h5000 cSt at 25 deg.C (e.g. a straight silicone oil such as octamethyltrisiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, methylpolysiloxane, dimethylpolysiloxane, methylpolycyclosiloxane, trimethylsiloxysilicic acid or octamethylcyclotetrasiloxane-silicon polyether copolymer, or its copolymer with a polyoxyalkylene).

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a pest repellent.

[0002]

2. Description of the Related Art Conventionally, various pest repellents have been used to repel pests such as mosquitoes, but those currently mainly used are merely effective ingredients. Many of them were only dissolved in alcoholic solvents, and their residual efficacy tended to decrease due to the outflow of the active ingredient due to perspiration during summer use. In addition, although it is possible to prevent the outflow of the active ingredient due to perspiration by using the one in which the active ingredient is simply dissolved in a fat-soluble solvent, not only is the feeling of use not good when the pest repellent is applied to the skin, but also the active ingredient. Since the volatilization effect of the above was not good, the pest repellent effect, especially the initial effect, tended to be inferior.

[0003]

Means for Solving the Problems The present invention has been made through extensive studies to develop a pest repellent excellent in initial effect and durability of efficacy, and is described in US Pat. No. 5,130,136. Karan-3,4-diol, which is an active ingredient for pest repellent, and a specific silicone oil, that is, the viscosity is 25 ° C.
At 5000 cSt or less, preferably 3000 cS
The present invention provides a pest repellent containing a silicone oil of t or less.

The silicone oil used in the present invention is a polymer having a siloxane bond, such as octamethyltrisiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane. , Methylpolysiloxane, dimethylpolysiloxane, methylpolycyclosiloxane, trimethylsiloxysilicic acid, octamethylcyclotetrasiloxane, straight silicone oils such as silicon polyether copolymers, copolymers with polyoxyalkylenes (specific examples are dimethylsiloxane -Methyl (polyoxyethylene) siloxane copolymer, dimethyl siloxane-methyl (polyoxyethylene polyoxypropylene) siloxane copolymer] Etc. can be mentioned, can also be used as a mixture of two or more silicone oils, viscosity at 25 ° C. In that case, even mixed silicone oil is 500
It may be 0 cSt or less. The amount of these silicone oils used is 0.02 to 10 parts by weight, preferably 0.1 to 3 parts by weight, relative to 1 part by weight of curane-3,4-diol.

Karan-3,4 used in the present invention
-The diol has various stereoisomers, and any active isomer or a mixture thereof can be used, but 1S, 3S,
4S, 6R-carane-3,4-diol, 1S, 3R,
4R, 6R-carane-3,4-diol or a carane-3,4-diol mixture having an increased mixing ratio thereof is preferred because of high activity, and particularly 1S, 3S, 4S,
The use of 6R-calane-3,4-diol is preferred.

The pest repellent of the present invention further includes other pests.
A repellent active ingredient can also be added, and as the active ingredient
Is N, N-diethyl-m-toluamide, dimethylphthalate
Rate, 2-ethyl-1,3-hexanediol, N-
Octyl bicycloheptane dicarboximide, p-me
Ethane-3,8-diol, 2,3,4,5-bis (△
²-Butylene) tetrahydrofurfural, di-n-p
Ropylisocin comeronate, di-n-butyl succine
, Diethylmandelic acid amide, 2-hydroxyethyl
Luoctyl sulfide, empentrin, etc.
It

The pest repellent of the present invention is Anopheles a lbiman.
Anopheles such as us (Anopheles sp.), Aedes aegypti, Aedes such as Aedes albopictus (Aedes sp.), Culex pipiens, Culex such as Culex (Culex sp.)
Blood-sucking insects such as mosquitoes, black flies, sand flies, sand flies, nukaka, Amblyomma, Rhipicephalus, Dermacentor
, Ixodes, Haemaphysalis, Boophilus, and other arthropods.

The pest repellent of the present invention is usually used by preparing it in various forms such as a lotion, a solution such as an aerosol, a cream, etc., which is held in an appropriate carrier. Examples of the carrier used include water, alcohol solvents (for example, monohydric alcohols such as ethyl alcohol, propyl alcohol, butyl alcohol, stearyl alcohol, cetyl alcohol, propylene glycol, dipropylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol). Such as glycols, glycerin), hydrocarbons (eg pentane, liquid paraffin, petrolatum), esters (eg ethyl acetate, isopropyl palmitate, isopropyl myristate,
Diisopropyl adipate, beeswax, lanolin), animal and vegetable oils (eg castor oil, olive oil, corn oil) and the like can be mentioned. Further, the pest repellent of the present invention, an emulsifier, a dispersant, a spreading agent, a wetting agent, a suspending agent, a preservative, a film forming agent,
It is also possible to add formulation aids such as propellants and solid powders. Furthermore, it can be used after being microencapsulated or ribosomeized and then formulated.

Examples of emulsifiers and dispersants include soaps, polyoxyethylene fatty acid alcohol ethers such as polyoxyethylene oleyl ether, polyoxyethylene alkylaryl ethers such as polyoxyethylene nonylphenyl ether, polyoxyethylene fatty acid esters, and the like. Examples thereof include fatty acid glycerides, sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, sulfuric acid esters of higher alcohols, alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, lecithins such as egg yolk lecithin and soybean lecithin.

Examples of the film-forming agent include cellulose derivatives such as nitrocellulose, acetylcellulose, acetylbutyrylcellulose, ethylcellulose, methylcellulose and hydroxypropylcellulose, polyvinyl acetate, sodium polyacrylate, polymethyl methacrylate, polyvinyl. Examples thereof include alcohols, vinyl resins such as polyvinylpyrrolidone, and polysaccharides such as pullulan, starch, and dextrin.

Examples of the propellant include dimethyl ether, LPG, chlorofluorocarbon, carbon dioxide gas, nitrogen and air.

The solid powder includes, for example, silicon compounds such as talc, kaolin, bentonite and silica, oxides such as titanium oxide, magnesium oxide, aluminum oxide and zinc oxide, carbonates such as magnesium carbonate, calcium carbonate and sodium carbonate. , Sulfate such as zinc sulfate, zinc chloride,
Hydrochlorides such as iron chloride and aluminum chloride, nylon resin powder, polyethylene resin powder and the like can be mentioned.

The pest repellent of the present invention may further contain a synergist, a fragrance, a lubricant, a bactericide, a storage stabilizer, a dye, an ultraviolet absorber, an ultraviolet blocking agent and the like.

[0014]

EXAMPLES The present invention will be described more specifically below with reference to production examples and test examples. In the production examples, parts represent parts by weight. Production Example 1 1S, 3S, 4S, 6R-carane-3,4-diol 5
Parts and dimethyl siloxane-methyl (polyoxyethylene) siloxane copolymer [viscosity at 25 ° C 400c
St] 5 parts and dissolved in ethanol to make 60 parts as a whole, and filled in an aerosol container. Next, a valve is attached to the aerosol container, and the LPG 40 is passed through the valve portion.
The parts are pressure filled to obtain an aerosol.

Production Example 2 6 parts of stearic acid, 0.5 part of lanolin and Tween 60
(ICI American polyoxyethylene sorbitan monostearate) A mixture of 6 parts was heated to 80 ° C., and this was added to a mixture of 75 parts of water heated to 60 ° C. and 2.5 parts of salicylic acid, and stirred for 1S. , 3S, 4S, 6R-
A lotion is obtained by adding 5 parts of curane-3,4-diol and 5 parts of dimethylpolysiloxane [viscosity 5 cSt at 25 ° C.].

Production Example 3 1S, 3S, 4S, 6R-carane-3,4-diol 5
Part, a mixture of 3 parts of trimethylsiloxysilicic acid and 2 parts of methylpolysiloxane [viscosity at 25 ° C. 10 cSt],
Add 10 parts of stearic acid, 2 parts of cetyl alcohol, 1 part of lanolin, 2 parts of liquid paraffin and 60 parts of water and heat to mix. 13 parts of heated glycerin is added to this and well stirred to obtain a cream.

Test Example 1S, 3S, 4S, 6R-carane-3,4-diol 1
To 1 part by weight, 1 part by weight of each silicone oil shown in Table 1 below is added, and ethanol is added to add 1S, 3
3.33 w / v of S, 4S, 6R-carane-3,4-diol
% Solution. Removes hair from the abdomen of chicks, 1S, 3S, 4
The coating amount of S, 6R-carane-3,4-diol is 3 g /
treated to about m ² and about 300 female mosquitoes (Aedes Ae
The abdomen of the chick was placed on a cage containing gypti), and the number of attracted animals was examined 2 minutes later. As a control, we also investigated the number of mosquitoes that were similarly attracted using untreated chicks. The same attraction test was conducted after 1 and 2 hours. Table 2 shows the results. The repellent rate (%) in the table is calculated by the following formula

[0018]

[Equation 1] Determined by

[0019]

[Table 1] ^* 7: 3 (w / w) mixture of methyl polysiloxane of Experiment No. 1 and methyl polysiloxane of Comparative Experiment 1.

[0020]

[Table 2]

[0021]

INDUSTRIAL APPLICABILITY The pest repellent of the present invention is a composition excellent in initial effect and durability.

Claims (2)

[Claims] 1. A calan-3,4-diol and a viscosity of 25 ° C.
And a silicone oil of 5000 cSt or less are included. 2. Caran-3,4-diol is 1S, 3
The pest repellent according to claim 1, which is S, 4S, 6R-carane-3,4-diol.