JPH0873322A - Trichogenic hair-growing agent - Google Patents
Trichogenic hair-growing agentInfo
- Publication number
- JPH0873322A JPH0873322A JP23862694A JP23862694A JPH0873322A JP H0873322 A JPH0873322 A JP H0873322A JP 23862694 A JP23862694 A JP 23862694A JP 23862694 A JP23862694 A JP 23862694A JP H0873322 A JPH0873322 A JP H0873322A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- growth
- trichogenic
- carboxyl group
- growing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は発毛、育毛剤に関し、更
に詳しくは、抜け毛を防止し、顕著な発毛効果及び育毛
効果を有するポリアミノ酸からなる発毛、育毛剤に関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growth and hair-growth agent, and more particularly, to a hair-growth and hair-growth agent which prevents hair loss and comprises polyamino acids having remarkable hair-growth and hair-growth effects.
【０００２】[0002]
【従来の技術】従来から各種の薬効成分を配合した発
毛、育毛剤が提案され、販売されているが、確実な効果
を有するものは未だ開発されていない。稀に、産毛様の
毛が生える養毛剤もあり多少の効果を認めることはでき
るが、発毛した毛があまりにも細く短いため、外観上は
依然として禿頭であり、実質的効果を認めることはでき
ない。2. Description of the Related Art Conventionally, hair growth and hair growth agents containing various medicinal components have been proposed and sold, but those having a certain effect have not yet been developed. Rarely, there is a hair nourishing agent that produces nap-like hair, but some effect can be recognized, but since the hair that has grown is too thin and short, it is still bald in appearance and no substantial effect can be recognized.
【０００３】一方、アミノ酸の重合体であるポリアミノ
酸については従来から種々の応用分野が検討されてき
た。特に、繊維分野においては活発な研究開発が進めら
れ、種々の応用の可能性が考えられている。ポリアミノ
酸の応用形態として、ポリアミノ酸膜、球状ポリアミノ
酸等があり、膜化したものは高透湿性防水素材として実
用化されている。一方、球状のポリアミノ酸は高速液体
クロマトグラフィー用充填材、人工キャリヤー蛋白質、
免疫診断試薬、或いは化粧品担体などの応用が検討され
てきたが、未だ実用化されていない。On the other hand, various application fields have been studied for polyamino acids, which are polymers of amino acids. In particular, active research and development have been promoted in the field of textiles, and various application possibilities are considered. There are polyamino acid membranes, spherical polyamino acids, and the like as applied forms of polyamino acids, and the membrane-formed ones have been put to practical use as a highly moisture-permeable waterproof material. On the other hand, spherical polyamino acids are used as packing materials for high performance liquid chromatography, artificial carrier proteins,
The application of immunodiagnostic reagents or cosmetic carriers has been studied, but it has not been put to practical use.
【０００４】[0004]
【発明が解決しようとする課題】客観的に効果が認めら
れる発毛、育毛剤は、明らかな抜け毛防止効果を有し、
且つ発毛周期の自然なサイクルにより発毛させると共
に、発毛した毛を充分な太さと長さに成長させるもので
なければならない。かかる発毛、育毛剤は長く求められ
ていたにもかかわらず、現在まで客観的に実効のある発
毛、育毛剤は存在しなかった。Problems to be Solved by the Invention A hair-growth and hair-growth agent which is objectively recognized has a clear hair loss prevention effect,
In addition, it is necessary to grow hair by a natural cycle of the hair growth cycle and to grow the grown hair to a sufficient thickness and length. Despite the long-felt need for such hair growth and hair-growth agents, until now there has been no objectively effective hair growth and hair-growth agent.
【０００５】[0005]
【課題解決の手段】本発明は上記課題を解決することを
目的とし、その構成は、次式に示すＬ−アミノ酸からな
るポリアミノ酸The present invention is intended to solve the above-mentioned problems, and its constitution is a polyamino acid comprising an L-amino acid represented by the following formula.
【化２】 （但し、ｎは３０から５００の整数、Ｒ1 は炭素数１〜
１０のアルキル基、Ｒ2は水素または炭素数１〜３のア
ルキル基である。）を有効成分とすることを特徴とし、
更に上記化合物が球状であり、多孔性であることを特徴
とする。Embedded image (However, n is an integer of 30 to 500, R 1 is a carbon number of 1 to 1.
10 is an alkyl group, R 2 is hydrogen or an alkyl group having 1 to 3 carbon atoms. ) As an active ingredient,
Further, the above compound is characterized in that it is spherical and porous.
【０００６】すなわち、本発明に係る発毛、育毛剤の有
効成分はγ−カルボキシル基がエステル化されたグルタ
ミン酸の縮重合体であり、末端カルボキシル基がアミン
で封鎖されている化合物である。場合によってはγ−カ
ルボキシル基はエステル化されている必要はない。That is, the active ingredient of the hair-growth and hair-growth agent according to the present invention is a condensation polymer of glutamic acid in which the γ-carboxyl group is esterified, and the terminal carboxyl group is a compound capped with an amine. In some cases, the γ-carboxyl group need not be esterified.
【０００７】本発明ポリアミノ酸はＬ−アミノ酸の縮重
合体であり、平均重合度は３０から５００、好ましくは
６０〜４００、より好ましくは１５０〜３５０である。
平均重合度が３０より小さいと人体に吸収されて抗体を
形成するおそれがあり、５００より大きいと粘度が上が
り、好ましい効果も得られない。The polyamino acid of the present invention is a polycondensation product of L-amino acid and has an average degree of polymerization of 30 to 500, preferably 60 to 400, more preferably 150 to 350.
If the average degree of polymerization is less than 30, it may be absorbed by the human body to form an antibody, and if it is more than 500, the viscosity is increased, and a preferable effect cannot be obtained.
【０００８】Ｌ−グルタミン酸のγ位のカルボキシル基
はアルキルエステル化する。γ−カルボキシル基をエス
テル化するアルキル基としてはメチル基、エチル基、ｎ
−プロピル基、ｉ−プロピル基などの炭素数１〜３のア
ルキル基が挙げられ、好ましくはメチル基である。アル
キル基の炭素数が増加するに従って養毛効果が減少する
傾向がある。The carboxyl group at the γ-position of L-glutamic acid is converted into an alkyl ester. As the alkyl group for esterifying the γ-carboxyl group, a methyl group, an ethyl group, n
Examples thereof include an alkyl group having 1 to 3 carbon atoms such as -propyl group and i-propyl group, and a methyl group is preferable. The hair-feeding effect tends to decrease as the number of carbon atoms in the alkyl group increases.
【０００９】重合度を調整するために末端カルボキシル
基はアミンで封鎖する。使用するアミンはアルキルアミ
ンが好ましいが、アルケニルアミンであってもよい。ア
ルキル基としては炭素数１〜１０のアルキル基が好まし
く、直鎖アルキル基に限らず分枝したアルキルアミンや
脂環族アルキルアミンも使用され、また１級アミンに限
定せず、２級及び３級アミンも使用できる。例えば、メ
チルアミン、エチルアミン、ｎ−及びｉ−プロピルアミ
ン、ｎ−及びｉ−ブチラミン、ｔ−メチル−メチラミ
ン、ｎ−及びｉ−ペンタミン、ｎ−、ｉ−及びシクロ−
ヘキサミン等を例示することができる。本発明に係る物
質を重合するにあたり、アミンの添加量を増加すると重
合体の分子量が減少し、アミンの添加量を減らすと重合
体の分子量が増加する。The terminal carboxyl group is blocked with an amine in order to adjust the degree of polymerization. The amine used is preferably an alkylamine, but may be an alkenylamine. As the alkyl group, an alkyl group having 1 to 10 carbon atoms is preferable, not only a linear alkyl group but also a branched alkylamine or an alicyclic alkylamine is used, and the secondary amine is not limited to a primary amine. Primary amines can also be used. For example, methylamine, ethylamine, n- and i-propylamine, n- and i-butyramine, t-methyl-methylamine, n- and i-pentamine, n-, i- and cyclo-.
Hexamine and the like can be exemplified. In polymerizing the substance according to the present invention, the molecular weight of the polymer is decreased by increasing the addition amount of the amine, and the molecular weight of the polymer is increased by decreasing the addition amount of the amine.
【００１０】本発明に係る化合物は粉末状、ペースト
状、シート状（破砕して使用する）などがあるが球状が
好ましい。粒径は５〜５００μｍ、好ましくは１０〜１
００μｍである。５μｍ未満では人体に吸収されるおそ
れがあり、１００μｍを越えると頭皮に塗布する薬剤と
して製剤するにあたっての分散性を失う。球状にするに
あたっては、本発明化合物と反応しない揮発性有機溶媒
に溶解し、例えば、部分ケン化ポリビニルアルコールな
どの親水性高分子化合物水溶液に懸濁させる。そのまま
撹拌し続けることにより生成した液滴は有機溶媒の蒸発
によって収縮し、球状のまま凝縮、固化する。The compound according to the present invention may be in the form of powder, paste, sheet (crushed and used) or the like, but spherical is preferred. The particle size is 5 to 500 μm, preferably 10 to 1
It is 00 μm. If it is less than 5 μm, it may be absorbed by the human body, and if it exceeds 100 μm, the dispersibility in formulation as a drug to be applied to the scalp is lost. To make the particles spherical, they are dissolved in a volatile organic solvent that does not react with the compound of the present invention, and suspended in an aqueous solution of a hydrophilic polymer compound such as partially saponified polyvinyl alcohol. The droplets generated by continuing stirring as it is are contracted by evaporation of the organic solvent, and are condensed and solidified in a spherical shape.
【００１１】また、粒子を多孔性にしたい場合には、第
三成分として球状化工程で蒸発せず、ポリアミノ酸と相
溶性を有しない希釈剤を加えて、上記球状化工程を行
う。その後、第三成分を溶解する溶媒で希釈剤を洗浄、
除去することにより多孔性の球状体が得られる。得られ
た多孔性球状体は連続気泡性であり、空隙率は１０〜６
０％、好ましくは２０〜４０％である。希釈材として
は、例えば、デカヒドロナフタレン、ジエチルベンゼ
ン、ジエチルヘキシルフタレート、ドデカン酸メチル及
びオレイン酸等を挙げることができる。When it is desired to make the particles porous, the above spheroidizing step is carried out by adding a diluent which does not evaporate in the sphering step and is not compatible with the polyamino acid as the third component. After that, wash the diluent with a solvent that dissolves the third component,
By removing it, a porous spherical body is obtained. The obtained porous spheres were open-celled and had a porosity of 10 to 6
It is 0%, preferably 20 to 40%. Examples of the diluent include decahydronaphthalene, diethylbenzene, diethylhexylphthalate, methyl dodecanoate and oleic acid.
【００１２】本発明に係る化合物を発毛、育毛剤として
使用する場合には、塗布できるものであればその剤型に
限定はなく、他の基剤を加えて有効成分の含有量を１〜
５０重量％、好ましくは５〜２０重量％のクリーム、乳
液等として使用できる。When the compound according to the present invention is used as a hair-growth and hair-growth agent, the dosage form is not limited as long as it can be applied, and other bases may be added to adjust the content of the active ingredient to 1 to 1.
It can be used as a cream, emulsion or the like in an amount of 50% by weight, preferably 5 to 20% by weight.
【００１３】[0013]
【作用】本発明者は、年齢と共に頭髪が薄くなる現象
は、皮脂腺中に育毛抑制物質が分泌されるか、或いは蓄
積されるとの仮説の下に、この抑制物質と結合し、抑制
物質の作用を発現させない物質を検討してきた。その結
果、ポリアミノ酸、中でも（１）式の化合物が発毛及び
育毛に顕著な効果を有することを見出して完成したもの
である。特に、ポリ−γ−メチル−Ｌ−グルタメートの
球状体は顕著な効果を有する。本発明のポリ−Ｌ−グル
タメート誘導体は、体内に吸収されない程度の分子量で
あり、頭髪にすり込むことにより皮脂腺と接触し、皮脂
腺から分泌した抑制物質と反応し、その作用を発現させ
ないものと推量する。The present inventor combined with this inhibitor under the hypothesis that the phenomenon of thinning hair with age is secreted or accumulated in the sebaceous glands, We have investigated substances that do not exert their effects. As a result, they have completed the finding that polyamino acids, particularly the compound of formula (1), have a remarkable effect on hair growth and hair growth. In particular, poly-γ-methyl-L-glutamate spheroids have a significant effect. The poly-L-glutamate derivative of the present invention has such a molecular weight that it is not absorbed into the body, and when it is rubbed into the hair, it comes into contact with the sebaceous gland, reacts with the inhibitory substance secreted from the sebaceous gland, and it is presumed that it does not exert its action. .
【００１４】また、球状化し、更に多孔性とした本発明
に係るポリアミノ酸は上記抑制物質との化学的親和性も
さることながら、粒子表面に存在する連続気泡の空孔に
よる吸着機構が関与しているとも考えられる。更に、ポ
リ−Ｌ−グルタメートを含めてその誘導体は、人工皮膚
としての用途も検討されているもので、皮膚に対する刺
激は全くなく、その安全性は確認されていると共に皮膚
から吸収されることはない。Further, the polyamino acid according to the present invention, which is made spherical and more porous, is involved in the adsorption mechanism by the pores of the open cells existing on the particle surface, in addition to the chemical affinity with the inhibitor. It is also possible that Further, its derivatives, including poly-L-glutamate, are also being studied for use as artificial skin, have no irritation to the skin, and their safety has been confirmed and that they will not be absorbed from the skin. Absent.
【００１５】[0015]
【実施例】実施例１ ポリ−γ−メチル−Ｌ−グルタメートの多孔質球状粒子（平均粒径１００μｍ 、商標名：アジコート、味の素（株）製） １０重量％ 白色ワセリン ４５重量％ 流動パラフィン ４５重量％ をよく混合してクリームタイプの発毛、育毛剤を製造し
た。 Example 1 Porous spherical particles of poly-γ-methyl-L-glutamate (average particle size 100 μm, trade name: Ajikot, manufactured by Ajinomoto Co., Inc.) 10% by weight White petrolatum 45% by weight Liquid paraffin 45% by weight % Was mixed well to produce a cream type hair growth and hair growth agent.
【００１６】上記発毛、育毛剤を４０才前後の禿頭及び
うす毛の男性６人をパネラーとして試験を行った。試験
方法は７日間連続して１日１回洗髪し、１回の洗髪時の
抜け毛の本数を数え、１日の抜け毛数の平均値を「使用
前」として表１に記入した。次いで、実施例１で製造し
た発毛、育毛剤を、４週間にわたり１日１回頭皮に塗布
し続けた。その後、７日間連続して１日１回洗髪し、１
回の洗髪時の抜け毛本数を数えて１日の抜け毛数を「使
用後」として表１に併記した。The above hair-growth and hair-growth agents were tested by using 6 males with bald and thin hair around the age of 40 as panelists. The test method was to wash the hair once a day for seven consecutive days, count the number of hair loss during each hair wash, and enter the average value of the number of hair loss per day as "before use" in Table 1. Then, the hair growth and hair-growth agent produced in Example 1 was continuously applied to the scalp once a day for 4 weeks. After that, wash your hair once a day for 7 consecutive days.
The number of hair loss at the time of washing the hair once was counted, and the number of hair loss per day was recorded as "after use" in Table 1.
【００１７】[0017]
【表１】 [Table 1]
【００１８】実施例２ ３８才の円形脱毛症の男性に実施例１の発毛、育毛剤を
使用した。このパネラーは数年来持続している難治性の
円形脱毛症であったが、本発明発毛、育毛剤塗布３週間
後から産毛が生え始め、約８週間後には外観上治癒とい
える状態にまで改善された。 Example 2 The hair-growth and hair-growth agent of Example 1 was used for a 38 year old male with alopecia areata. This panelist had a refractory alopecia areata that has been persisting for several years, but after 3 weeks from the application of the hair growth and hair-growth agent of the present invention, hair regrowth began, and after about 8 weeks, the hair appeared to be cured. Improved.
【００１９】実施例３ ４３才のうす毛の女性に実施例１の発毛、育毛剤を使用
した。２ケ月の使用後、客観的に毛髪の膨らみ感が確認
された。本実施例に関してはなお継続試験中である。 Example 3 The hair-growth and hair-growth agent of Example 1 was used for a 43-year-old woman with thin hair. After using for 2 months, the bulging feeling of the hair was objectively confirmed. Continuing testing is still underway for this example.
【００２０】[0020]
【発明の効果】本発明により、人体に無害で、安全な実
効のある発毛、育毛剤を提供することに成功した。The present invention succeeded in providing a safe and effective hair growth and hair-growing agent that is harmless to the human body.
【化３】 [Chemical 3]
Claims (2)
ノ酸 【化１】 （但し、ｎは３０から５００の整数、Ｒ1 は炭素数１〜
１０のアルキル基、Ｒ2は水素または炭素数１〜３のア
ルキル基である。）を有効成分とする発毛、育毛剤。1. A polyamino acid consisting of an L-amino acid represented by the following formula: (However, n is an integer of 30 to 500, R 1 is a carbon number of 1 to 1.
10 is an alkyl group, R 2 is hydrogen or an alkyl group having 1 to 3 carbon atoms. ) Is a hair growth and hair growth agent.
とを特徴とする請求項第１項記載の発毛、育毛剤。2. The hair-growing and hair-growing agent according to claim 1, wherein the polyamino acid is spherical and porous.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23862694A JPH0873322A (en) | 1994-09-07 | 1994-09-07 | Trichogenic hair-growing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23862694A JPH0873322A (en) | 1994-09-07 | 1994-09-07 | Trichogenic hair-growing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0873322A true JPH0873322A (en) | 1996-03-19 |
Family
ID=17032946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23862694A Pending JPH0873322A (en) | 1994-09-07 | 1994-09-07 | Trichogenic hair-growing agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0873322A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9554979B2 (en) | 2011-10-03 | 2017-01-31 | The Procter & Gamble Company | Hair care compositions and methods of use |
| US10123966B2 (en) | 2013-05-16 | 2018-11-13 | The Procter And Gamble Company | Hair thickening compositions and methods of use |
-
1994
- 1994-09-07 JP JP23862694A patent/JPH0873322A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9554979B2 (en) | 2011-10-03 | 2017-01-31 | The Procter & Gamble Company | Hair care compositions and methods of use |
| US10123966B2 (en) | 2013-05-16 | 2018-11-13 | The Procter And Gamble Company | Hair thickening compositions and methods of use |
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