JPH08511529A - 14-Substituted Marcfortine and Derivatives Useful as Antiparasitic Agents - Google Patents

Abstract

There are disclosed 14 alpha -hydroxymarcfortine derivatives of the natural products marcfortine A, B, C, and D useful in the treatment and prevention of helminth and arthropod infections of animals and plants. The synthetic derivatives are of Formula (I).

Description

Detailed Description of the Invention         14-Substituted Marcfortine and Derivatives Useful as Antiparasitic Agents                                 BACKGROUND OF THE INVENTION   Marcfortine is a known compound and is available from Journal of the Chemical Society of Chemicals (Journal of the Chemical Society Chemical Communications), 1980, pp. 601-602 (Marc Ho) Rutin A) and Tetrahedron Letters, 198. 1 year, Vol. 22, 1977-1980 (Marcfortine B and C) Disclosed by Polonsky et al. The compound is penicillium It is a fungal metabolite of Penicillium roqueforti. The markho Rutin is structurally similar to paraherkamide, another known compound . The paraherkamide is tetrahedron letters (Tetrahedron Letters) , 1981, 22: 135-136, Yamazaki et al. Therefore, the Journal of Antibiotics , 1991, Vol. 44, pages 492-497 (Blanchf lower) and others. U.S. Pat. Nos. 4,866,060 and 4, No. 923,867 is useful for treating and preventing parasitic diseases in animals. Discloses the use of Marcfortine A, B and C, and certain derivatives thereof. There is.   WO 92/22555 (published December 23, 1992) generally discloses that Marcfortine or paraherkamide derivatives (ie methyl or 14 at position 14 Discloses a partial formula (III) substituted with methyl and hydroxy. How to produce 14-methyl-14-hydroxymarcfortine compound Not listed at all.   Paraherkamide has the following structure:   Marcfortine A has the following structure:   Marcfortine B has the following structure:   Marcfortine C has the following structure:   Marcfortine D has the following structure:   WO 91/09961 (published on July 11, 1991) is Marc Hol Various derivatives of tin and paraherkamide, and their 12a-N-oxy groups And especially Penicillium sp. IMI33299 5 from VM29919 (paraherkamide) and VM55596 (paraherkamide) The preparation of the product of the amide 12a-N-oxide) is disclosed.   U.S. Pat. No. 4,873,247 discloses a derivative of paraherkamide and Penicillium charlessi M for quartamide production F5123 (ATCC 20841) is disclosed. U.S. Pat. No. 4,978,6 No. 56 (as well as EP 390532-A and EP 301742-A) , Various synthetic derivatives of paraherkamide, and Penicillium charlesi (Penicillium charlessi) Paraha from MF5123 (ATCC 20841) Disclosed is the production of quartamide.   International Publication Number WO 92/22555 (published December 23, 1992) At SmithKline Beecham, Inc. For the production of 4-α-hydroxy-marcfortine compounds and antiparasitic drugs Discloses the use of 14-hydroxy-14-methylmarcfortine compound It However, 14α-hydroxy-marcfortine or 14α-hydroxy Any means capable of producing a ss-14β-methyl-marcfortine compound is described. Not listed.                                 Summary of the invention   The present invention provides 14-substituted marcfortine A, B, C and D and their derivatives. It relates to the synthesis of conductors as well as the use of these compounds as antiparasitic agents. Scratch The object of the present invention is then to describe these marcfortine derivatives. A further object of the present invention is to describe the preparation of these compounds. Nasasa A further object is to embody the present invention as an antiparasitic agent in the treatment and prevention of parasitic diseases. To describe the use of compound. Still a further object is the novel compounds of the present invention. To describe a composition for treating parasitic diseases, which comprises as an active ingredient thereof. It Further objectives will become apparent upon reading the description below.                                 Description of the invention   The compounds of the present invention have the formula I: [In the formula,   m is 0 or 1;   Z is O or S;   Y is an oxygen atom (-O-) or a bond;   R₁Is hydrogen, C₁-C₇Alkyl, cyclo C₃-C₈Alkyl, benzyl, {desirably More, carboxy (-COOH), C₁-C₇Alkanoyl, carbo C₁-C₇Arco Xy (-C (O) OC₁-C₇Alkyl), -NR_FourR_Five, Aminocarbonyl (-C (O) N R_FourR_Five) May be substituted with} C₂-C₇Alkanoyl (-C (O) C₂-C₇Al Kill), C_Ten-C_{twenty four}Alkanoyl (-C (O) C_Ten-C_{twenty four}) Alkyl), {optionally R, carboxy, C₁-C₇Alkanoyl, carbo C₁-C₇Alkoxy, -NR_FourR_Five , Optionally substituted with aminocarbonyl} cycloC₃-C₈Alkanoyl, a Lucanoyloxymethylene (-CH₂OC (O) -C₂-C₇Alkyl), {if desired , Halogen, C₁-C_FourAlkyl, halo C₁-C₇Alkyl, nitro, cyano and C₁ -C₇Optionally substituted with 1 or 2 groups selected from alkoxy} Nzoyloxymethylene (-CH₂OC (O) phenyl), C_Ten-C_{twenty four}Alkenoyl (-C (O) C₉-C_{twenty three}Alkenyl), {optionally halogen, C₁-C_FourAlkyl, Halo C₁-C₇Alkyl, nitro, cyano and C₁-C₇Selected from alkoxy 1 or 2 groups may be substituted} benzenesulfonyl (-SO₂CH₂ Phenyl), C₁-C_FourAlkylaminocarbonyl (-C (O) N (C₁-C_FourAlkyl)₂ ), C₁-C_FourAlkylaminothiocarbonyl (-C (S) N (C₁-C_FourAlkyl)₂), C₁-C₇Alkoxycarbonyl, {optionally halogen, C₁-C_FourAlkyl, ha B C₁-C₇Alkyl, nitro, cyano and C₁-C₇1 selected from alkoxy Or optionally substituted with two groups} phenoxycarbonyl, -C (O) NR '_Four R '_Five, -P (= X) (R₂) (R₃),-SR₆, -SO₂NR_FourR_Five3rd or 4th place -CH₂NR_FourR_FiveBenzoyl substituted with or bicyclo C₈-C₁₂Arcanoi Le;   R_FourAnd R_FiveAre the same or different and are hydrogen, C₁-C₇Alkyl, {if desired , Halogen, C₁-C_FourAlkyl, halo C₁-C₇Alkyl, nitro, cyano and C₁ -C₇Optionally substituted with 1 or 2 groups selected from alkoxy} Phenyl, or together with N, forms a saturated or unsaturated heteroamine ring. To make;   R '_FourAnd R '_FiveAre the same or different, and C₁-C₇Alkyl, cyclo (C₃-C₈) A Rutile, {optionally halogen, C₁-C_FourAlkyl, halo C₁-C₇Alkyl, d Toro, Cyano and C₁-C₇Substituted with 1 or 2 groups selected from alkoxy Optionally combined with phenyl, or N, if desired, N, Containing 1 or 2 additional heteroatoms selected from O or S Form a saturated saturated amine ring;   X is O or S;   R₂And R₃Are the same or different, and C₁-C₇Alkyl, {optionally halo Gen, C₁-_FourAlkyl, halo C₁-C₇Alkyl, nitro, cyano and C₁-C₇A Optionally substituted with 1 or 2 groups selected from lucoxy} phenyl, C₁-C₇Alkoxy, thio (C₁-C₇) Alkoxy, phenoxy, thiophenoxy , -NR₇R₈{Here, R₇And R₈Are the same or different and are H, C₁-C₇Archi Selected from the group of R, or together with N to form a saturated heterocycle}, is Or together with P to form a 4- to 7-membered heterocycle;   R₆Is C₁-C₇Alkyl, halo C₁-C₇Alkyl, carbo C₁-C₇Alkoxy,- NR₉R_Ten{Here, R₉And R_TenAre the same or different, and C₁-C₇Alkyl Or (optionally halogen, lower alkyl, halo C₁-C₇Alkyl, nitro, Cyano, C₁-C₇Substituted by 1 or 2 groups selected from alkoxy Good) phenyl};   R_{twenty four}Is hydrogen, halogen or C₁-C₇Alkoxy;   R_{twenty five}Is hydrogen or halogen;   R_18aIs hydrogen, C₁-C₇Alkyl, C₂-C₈Alkoxyalkyl, C₂-C₈Arche Nil, C₂-C₈Alkynyl or benzyl;   R_14aIs hydroxyl, hydrogen, C₁-C₇Alkyl, C₂-C₈Alkoxy alkyl , Cyclo (C₃-C₈) Alkyl or (optionally halogen, lower alkyl, Halo C₁-C₇Alkyl, nitro, cyano, C₁-C₇1 selected from alkoxy Or optionally substituted with two groups) benzyl;   R_14bIs hydrogen, hydroxyl, C₁-C₇Alkoxy, cyclo (C₃-C₈) Al Kill or (optionally halogen, lower alkyl, halo C₁-C₇Alkyl, d Toro, Cyano, C₁-C₇Substituted by 1 or 2 groups selected from alkoxy Good) benzoxyl;   R_15aAnd R_15bAre both hydrogen, provided that R_14aOr R_14bOne of the is When it is sil, the other is hydrogen or methyl, and R_15aAnd R_15bIs hydrogen May be methyl;   The dashed line between carbons 24 and 25 represents a single or double bond; Then R_14aAnd R_14bAre not both hydrogen] Represented by   The compound of the present invention includes pharmaceutically acceptable salts thereof and 12a-N-oxy groups thereof. Are included.   In another aspect of the invention, formula IA: 14-substituted marcfortine A and B compounds are provided.   In another aspect of the invention, formula IB: 14-substituted thiomarkfortine A and B compounds are provided.   In another aspect of the invention, Formula II: 14-substituted marcfortine C and D compounds are provided.   In another aspect of the invention, Formula III: 14-substituted thiomarkfortine C and D compounds are provided.   The carbon content of various hydrocarbons containing groups is determined by the minimum and maximum number of carbon atoms in the group. Indicated by a prefix that represents. That is, the prefix C_i-C_jIs an integer "i" ~ integer Represents the carbon atom content of "j" carbon atoms. Therefore, C₁-C₃Alkyl is 1- Represents an alkyl of 3 carbon atoms, including methyl, ethyl, propyl and isop Includes Ropil.   Regarding the above, "C₁-C₇"Alkyl" means straight or branched 1 to 7 carbons. It is meant to include alkyl groups of elementary atoms. Examples of such lower alkyl groups are: Methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl , Pentyl, hexyl, heptyl and the like.   Cyclo (C₃-C₈) Alkyl is meant to include a 3-8 membered alkyl ring. To taste. Cyclo (C₃-C₈) Examples of alkyl groups are cyclopropyl, cyclobutyl , Cyclopentyl, cyclohexyl, cycloheptyl, bicyclo [2.2.1] Petit and so on.   C₁-C₈Alkoxy is a straight or branched chain alkoxy group of 1 to 8 carbon atoms. It is meant to include a Si group. Such C₁-C₈An example of an alkoxy group is methoxy , Ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, pentoxy And hexoxy, heptoxy and the like.   C₂-C₇Alkanoyl is a straight-chain or branched-chain alkanoyl of 2 to 7 carbon atoms. It is meant to include noyl groups. Such C₂-C₇As an example of an alkanoyl group Is acetyl, propionyl, isopropionyl, butyryl, pentanoyl, Xanoyl and the like are included.   C_Ten-C_{twenty four}Alkanoyl (-C (O) C₉-C_{twenty three}Alkyl) means straight or branched chain Is meant to include alkanoyl groups of 10 to 24 carbon atoms. Take C_Ten-C_{twenty four}Examples of the alkanoyl group include decanoyl [-C (O) (CH₂)₉CH₃] , Lauroyl [-C (O) (CH₂)_TenCH₃], Tridecanoyl [-C (O) (CH₂)₁₁ CH₃], Myristoyl [-C (O) (CH₂)₁₂CH₃], Pentadecanoyl [-C (O ) (CH₂)₁₃CH₃], Palmitoyl [-C (O) (CH₂) 14CH₃], Magaroyl [- C (O) (CH₂)_FifteenCH₃], Stearoyl [-C (O) (CH₂)₁₆CH₃], Arachid IL [-C (O) (CH₂)₁₈CH₃], Henicosanoyl [-C (O) (CH₂)₁₉CH₃] , Behenoyl [-C (O) (CH₂)₂₀CH₃], Tricosanoyl [-C (O) (CH₂)_{twenty one} CH₃], Tetracosanoyl [-C (O) (CH₂)_{twenty two}CH₃] Etc. are included.   C_Ten-C_{twenty four}Alkenoyl (-C (O) C₉-C_{twenty three}Alkenyl) means straight-chain or branched It is meant to include unsaturated groups of 10 to 24 carbon atoms in the chain. Such C_Ten -C_{twenty four}Examples of alkenoyl groups include: Undecylenoyl [-C (O) (CH₂)₇CH: CHCH₃], Oleoyl [-C (O) ( CH₂)₇CH: CH (CH₂)₇CH₃], Linoleyl [-C (O) (CH₂)₇CH: CH.C H₂.CH: CH (CH₂)_FourCH₃] Etc. are included.   "C₂-C₈The term "alkoxyalkyl" refers to a straight or branched chain of 2 to 8 carbons. A lower alkoxy group-substituted lower alkyl group containing an elementary atom and 1 to 3 oxygen atoms Means inclusion. Such C₂-C₈Examples of alkoxyalkyl groups are methoxy Cimethyl, methoxyethoxymethyl, methoxyethoxyethoxymethyl, etoki Includes ethyl and the like. C₁-C₈An example of alkoxymethyl is methoxymethyl , Ethoxymethyl, propoxymethyl, butoxymethyl, pentoxymethyl, Butoxymethyl, pentoxymethyl, hexoxymethyl and heptoxymethyl And their isomers.   The term alkanoyloxymethylene refers to a straight or branched chain 2 to 8 carbon atom. It is meant to include alkanoyloxy-substituted methylenes, including children. Such C₂ -C₈Examples of alkanoyloxymethylene groups include acetoxymethyl, tert-butane. It includes toxymethyl, n-propoxymethyl, valeroxymethyl and the like.   The term "substituted benzoyloxymethylene" refers to lower alkyl, trifluorome Chill, C₁-C₇Selected from alkoxy, nitro or cyano groups and halogen atoms A benzoyloxymethyl group in which the benzene ring is substituted with 0 to 3 substituents Means inclusion.   The term "substituted benzenesulfonyl" refers to lower alkyl, trifluoromethyl, C₁-C₇Selected from alkoxy, nitro or cyano groups and halogen atoms It includes a benzenesulfonyl group in which the benzene ring is substituted with 0 to 3 substituents. Means and.   The term "halogen" refers to the halogen atoms fluorine, chlorine, bromine and iodine. Is meant to include.   "Halo C₁-C₇The term "alkyl" refers to straight or branched chain 1 to 7 carbon atoms. And halogen-substituted C containing 1 to 3 halogen atoms₁-C₇Include alkyl Means that. Halo C₁-C₇Examples of alkyl include fluoromethyl, 2-brom Moethyl, 3-chloropropyl, 5-indopentyl, trifluoromethyl, etc. are included. Get caught   "C₂-C₈The term "alkenyl" contains one or two carbon-carbon double bonds. It is intended to include straight chain or branched lower alkyl groups containing 2 to 8 carbon atoms. means. Such C₂-C₈Examples of alkenyl groups include allyl, 3-butenyl, 2 , 4-pentadienyl, hexenyl and the like are included.   "C₂-C₈The term "alkynyl" contains one or two carbon-carbon triple bonds It is intended to include linear or branched alkynyl groups containing 1 to 8 carbon atoms. To taste. Such C₂-C₈Examples of alkynyl groups include propargyl, 2-butynyl 2,4-pentazinyl, 5-hexynyl and the like are included.   "Alkoxycarbonyl (-C (= O) O- (CH₂)_p-C₁-C₇Alkoxy) ”example Are ethoxycarbonyl, isopropoxycarbonyl, methoxycarbonyl And butoxycarbonyl, hexoxycarbonyl and the like. C₁-C₇Arca Noyl includes linear or branched alkyl groups of 1 to 7 carbon atoms. Means and. C₁-C₇Examples of alkanoyl include acetyl, propionyl, Iso-butyryl, valeryl, 5-methylhexanoyl and the like are included.   Aminocarbonyl (-C (= O) NR_FourR_Five) Is, for example, dimethylaminocarbo Nyl, propylmethylaminocarbonyl, dibutylaminocarbonyl, isopro Pyraminocarbonyl, hexylaminocarbonyl and the like are included.   Aminothiocarbonyl (-C (= S) NR_FourR_Five) Is an example of dimethylamino Ocarbonyl, propylmethylaminothiocarbonyl, dibutylaminothiocal Bonyl, isopentylaminothiocarbonyl, hexylaminothiocarbonyl, etc. Is included.   Group-P (= X) (R₂) (R₃), For example, diethylthiophosphoryl, phenyl Toxyphosphonyl, 2-thioxo-1,3,2-dioxaphosphoritinyl, N, N-di Methyl methoxyphosphoramidyl, diphenylphosphinyl and the like are included.   -SR₆Examples of are 2,4-dinitrobenzenesulfenyl, dimethylamino Sulfenyl, ethoxycarbonylsulfenyl, trichloromethylsulfenyl And 4-morpholino sulphenyl.   -SO₂NR_FourR_FiveExamples of are dimethylsulfamoyl, phenylmethylsulfate Famoyl, 4-morpholinosulfamoyl, piperidinylsulfamoyl, etc. included.   The term "phosphorus-containing heterocycle" refers to 1,3-dioxa-2-phosphorinane, 1-aza-3- Oxa-2-phosphorane, 1,3-diaza-2-phosphorane, 1-thia-3-oxa-2- It is meant to include phospholane and the like.   -NR_FourR_Five, -NR '_FourR '_FiveAnd-NR₇R₈Examples of heteroamine rings for :   4-morpholine,   4-phenyl-1-piperazine,   4- (2-pyridinyl) -1-piperazine,   2,6-dimethyl-4-morpholine,   1-pyrrolidine,   4-methyl-1-piperazine,   1-piperidine,   4-phenyl-1-piperidine,   Thiazolidine,   4-phenyl-1,2,3,6-tetrahydropyridine,   4-phenylpiperidine,   Ethyl proline,   Tetrahydrofurylamine,   3-pyrroline,   Thiazolidine-4-carboxylic acid,   Thiomorpholine,   Nipecotamide,   2-methylpiperidine,   3-methylpiperidine,   4-methylpiperidine,   N-methylpiperazine,   1-methylhomopiperazine,   1-acetylpiperazine,   It is N-carboethoxypiperazine.   A pharmaceutically acceptable salt means a salt useful for administering the compounds of the invention, Mesylate, hydrochloride, hydrobromide, hydroiodide, sulfate, phosphate, acetic acid Salt, propionate, lactate, maleate, malate, succinate, tartaric acid Salt and the like are included. These salts may be in the hydrated form.   Preferred compounds of the invention are (R_14aIs hydroxyl and hydrogen, R_14bIs hydrogen , Methyl and ethyl; R_{twenty four}And R_{twenty five}Is hydrogen; R_18aIs hydrogen, C₁-C_FourAlkyl , C₂-C_FourAlkoxyalkyl, C₂-C_FourAlkenyl or benzyl; charcoal The dashed line between elements 24 and 25 is a compound representing a double bond) Formulas IA and IB Is a compound of.   Examples of preferred compounds of the invention are as follows:   14β-methylmarcfortine A,   14β-ethylmarcfortine A, and   14α-hydroxy-14β-ethylmarcfortine A; more preferably   14α-hydroxy-14β-methylmarcfortine A;   14α-hydroxy-14β-methyl-15α-methylmarcfortine A; and Most preferably,   14α-hydroxymarcfortine A, and   14α-hydroxy-15α-methylmarcfortine A.   The following compounds (both of which are incorporated by reference and are considered part of this specification) (199 EP 0 354 615 A1 (published February 14, 2000) and (1 99 WO 93/10120 published May 27, 2013) PCT / US92 / 0 By using the method described in 9483, 14α-hydroxymarl Cufortine, 14α-hydroxy-14β-methyl Marcfortine, 14β-methyl Marcfortine, 14β-Ethylmarcfortine, or 14α-Hydroxy-1 4β-Ethylmarcfortine, 14α-Hydroxy-14β-methyl-15α-methyl From marcfortine and 14α-hydroxy-15α-methylmarcfortine Can be manufactured:   1-acetoxymethyl-14α-hydroxymarcfortine A;   1-diethoxyphosphoryl-14α-hydroxymarcfortine A;   1-dimethylsulfamoyl-14α-hydroxymarcfortine A;   1-cyclopropylcarbonyl-14α-hydroxymarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxymarcfortine A ;   1- (1-Piperidinyl) thiocarbonyl-14α-hydroxymarcfortine A ;   1-succinoyl-14α-hydroxymarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxymarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxymarkol Chin A;   24-propoxy-24,25-dihydro-14α-hydroxymarcfortine A;   1- (p-toluenesulfonyl) -14α-hydroxymarcfortine A;   1-acetyl-14α-hydroxymarcfortine A;   1-methyl-14α-hydroxymarcfortine A;   1-benzyl-14α-hydroxymarcfortine A;   1-dimethylcarbamoyl-14α-hydroxymarcfortine A;   1-methoxycarbonyl-14α-hydroxymarcfortine A;   14α-hydroxymarcfortine B;   24,25-dihydro-14α-hydroxymarcfortine B;   24-methoxy-24,25-dihydro-14α-hydroxymarcfortine B;   1- (p-toluenesulfonyl) -14α-hydroxymarcfortine B;   1-ethyl-14α-hydroxymarcfortine B;   1-benzyl-14α-hydroxymarcfortine B;   18a-ethyl-14α-hydroxymarcfortine B;   18a-benzyl-14α-hydroxymarcfortine B;   18a-methoxyethoxymethyl-14α-hydroxymarcfortine B;   18a-allyl-14α-hydroxymarcfortine B;   18a-propargyl-14α-hydroxymarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxymark Hortin B;   1,18a-bis-ethyl-14α-hydroxymarcfortine B;   1,18a-bis-benzyl-14α-hydroxymarcfortine B;   18a-ethyl-24-methoxy-14α-hydroxymarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-ethyl-24,25-dihydro-14α-hydroxymarcfortine B;   24,25-dihydro-14α-hydroxymarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-hydroxymarcfortine C;   1-propionyl-14α-hydroxymarcfortine C;   1-propyl-14α-hydroxymarcfortine C;   1-benzyl-14α-hydroxymarcfortine C;   18a-propyl-14α-hydroxymarcfortine C;   18a-benzyl-14α-hydroxymarcfortine C;   18a-methoxyethoxymethyl-14α-hydroxymarcfortine C;   18-allyl-14α-hydroxymarcfortine C;   18a-propargyl-14α-hydroxymarcfortine C;   1,18a-bis-propyl-14α-hydroxymarcfortine C;   1,18a-bis-benzyl-14α-hydroxymarcfortine C;   14α-hydroxymarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxymarcfortine A;   1-palmitoyl-14α-hydroxymarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxymarcfortine A;   1-palmitoyl-14α-hydroxymarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxymarcfortine D;   14α-hydroxymarcfortine D;   1-acetoxymethyl-14α-hydroxymarcfortine D;   1-diethoxyphosphoryl-14α-hydroxymarcfortine D;   1-dimethylsulfamoyl-14α-hydroxymarcfortine D;   1-cyclopropylcarbonyl-14α-hydroxymarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxymarcfortine D ;   1- (1-Piperidinyl) thiocarbonyl-14α-hydroxymarcfortine D ;   1-succinoyl-14α-hydroxymarcfortine D;   1- (4-morpholinosulfenyl) -14α-hydroxymarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxymarkol Chin D;   24-propoxy-24,25-dihydro-14α-hydroxymarcfortine D;   1- (p-toluenesulfonyl) -14α-hydroxymarcfortine D;   1-acetyl-14α-hydroxymarcfortine D;   1-methyl-14α-hydroxymarcfortine D;   1-benzyl-14α-hydroxymarcfortine D;   1-dimethylcarbamoyl-14α-hydroxymarcfortine D;   1-methoxycarbonyl-14α-hydroxymarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methylmarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methylmarcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methylmarkholch A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methylmarkol Chin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methylmer Lukhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methylmer Lukhortin A;   1-succinoyl-14α-hydroxy-14β-methylmarcfortine A;   1- (4-morpholine sulphenyl) -14α-hydroxy-14β-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tilmarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methylmarkol Chin A;   1-acetyl-14α-hydroxy-14β-methylmarcfortine A;   1-methyl-14α-hydroxy-14β-methylmarcfortine A;   1-benzyl-14α-hydroxy-14β-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methylmarcfortine A;   1-Methoxycarbonyl-14α-hydroxy-14β-methylmarcfortine A ;   14α-hydroxy-14β-methylmarcfortine B;   24,25-dihydro-14α-hydroxy-14β-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methylmarkol Chi B   1-ethyl-14α-hydroxy-14β-methylmarcfortine B;   1-benzyl-14α-hydroxy-14β-methylmarcfortine B;   18a-ethyl-14α-hydroxy-14β-methylmarcfortine B;   18a-benzyl-14α-hydroxy-14β-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methylmarkho Rutin B;   18a-allyl-14α-hydroxy-14β-methylmarcfortine B;   18a-propargyl-14α-hydroxy-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methylmarcfortine B;   1,18a-Bis-ethyl-14α-hydroxy-14β-methylmarcfortine B ;   1,18a-bis-benzyl-14α-hydroxy-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methylmarkol Chin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxy-14β-methylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methylmark Hortin B;   24,25-dihydro-14α-hydroxy-14β-methylmarcfortine C;   1- (p-Bromobenzenesulfonyl) -14α-hydroxy-14β-methylmar Kuhortin C;   1-propionyl-14α-hydroxy-14β-methylmarcfortine C;   1-propyl-14α-hydroxy-14β-methylmarcfortine C;   1-benzyl-14α-hydroxy-14β-methylmarcfortine C;   18a-propyl-14α-hydroxy-14β-methylmarcfortine C;   18a-benzyl-14α-hydroxy-14β-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methylmarkho Rutin C;   18-allyl-14α-hydroxy-14β-methylmarcfortine C;   18a-propargyl-14α-hydroxy-14β-methylmarcfortine C;   1,18a-Bis-propyl-14α-hydroxy-14β-methylmarcfortine C;   1,18a-bis-benzyl-14α-hydroxy-14β-methylmarcfortine C;   14α-hydroxy-14β-methylmarcfortine C;   1-palmitoyl-14α-hydroxy-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methylmarkho Rutin A;   1-palmitoyl-14α-hydroxy-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methylmarkho Rutin D;   14α-hydroxy-14β-methylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methylmarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methylmarkholch D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methylmarkol Chin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methylmer Lukhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methylmer Lukhortin D;   1-succinoyl-14α-hydroxy-14β-methylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tilmarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methylmarkol Chin D;   1-acetyl-14α-hydroxy-14β-methylmarcfortine D;   1-methyl-14α-hydroxy-14β-methylmarcfortine D;   1-benzyl-14α-hydroxy-14β-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-hydroxy-14β-ethylmarcfortine D;   1-methoxycarbonyl-14α-hydroxy-14β-ethylmarcfortine D ;   1-acetoxymethyl-14α-hydroxy-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-14β-ethylmarcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-ethylmarkholch A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-ethylmarkol Chin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-ethylmer Lukhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-ethylmer Lukhortin A;   1-succinoyl-14α-hydroxy-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-ethylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-E Tilmarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-ethylmal Kuhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-ethylmarkol Chin A;   1-acetyl-14α-hydroxy-14β-ethylmarcfortine A;   1-methyl-14α-hydroxy-14β-ethylmarcfortine A;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-ethylmarcfortine A;   1-Methoxycarbonyl-14α-hydroxy-14β-ethylmarcfortine A ;   14α-hydroxy-14β-ethylmarcfortine B;   24,25-dihydro-14α-hydroxy-14β-ethylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-ethylmark Hortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-ethylmarkho Rutin B;   1-ethyl-14α-hydroxy-14β-ethylmarcfortine B;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-ethyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-benzyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-ethylmarkho Rutin B;   18a-allyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-propargyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-ethylmarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-ethylmarcfortine B ;   1,18a-bis-benzyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-ethylmarkol Chin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxy-14β-ethylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-ethylmark Hortin B;   24,25-dihydro-14α-hydroxy-14β-ethylmarcfortine C;   1- (p-Bromobenzenesulfonyl) -14α-hydroxy-14β-ethylmal Kuhortin C;   1-propionyl-14α-hydroxy-14β-ethylmarcfortine C;   1-propyl-14α-hydroxy-14β-ethylmarcfortine C;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-propyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-benzyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-ethylmarkho Rutin C;   18-allyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-propargyl-14α-hydroxy-14β-ethylmarcfortine C;   1,18a-bis-propyl-14α-hydroxy-14β-ethylmarcfortine C;   1,18a-bis-benzyl-14α-hydroxy-14β-ethylmarcfortine C;   14α-hydroxy-14β-ethylmarcfortine C;   1-palmitoyl-14α-hydroxy-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-ethylmarkho Le Chin A;   1-palmitoyl-14α-hydroxy-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-ethylmarkho Rutin D;   14α-hydroxy-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-14β-ethylmarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-ethylmarkholch D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-ethylmarkol Chin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-ethylmer Lukhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-ethylmer Lukhortin D;   1-succinoyl-14α-hydroxy-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-ethylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-E Tilmarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-ethylmal Kuhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-ethylmarkol Chin D;   1-acetyl-14α-hydroxy-14β-ethylmarcfortine D;   1-methyl-14α-hydroxy-14β-ethylmarcfortine D;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine D;   1-acetoxymethyl-14β-methylmarcfortine A;   1-diethoxyphosphoryl-14β-methylmarcfortine A;   1-dimethylsulfamoyl-14β-methylmarcfortine A;   1-cyclopropylcarbonyl-14β-methylmarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14β-methylmarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14β-methylmarcfortine A;   1-succinoyl-14β-methylmarcfortine A;   1- (4-morpholinosulfenyl) -14β-methylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14β-methylmarcfortine A;   24-propoxy-24,25-dihydro-14β-methylmarcfortine A;   1- (p-toluenesulfonyl) -14β-methylmarcfortine A;   1-acetyl-14β-methylmarcfortine A;   1-methyl-14β-methylmarcfortine A;   1-benzyl-14β-methylmarcfortine A;   1-dimethylcarbamoyl-14β-methylmarcfortine A;   1-methoxycarbonyl-14β-methylmarcfortine A;   14β-methylmarcfortine B;   24,25-dihydro-14β-methylmarcfortine B;   24-methoxy-24,25-dihydro-14β-methylmarcfortine B;   1- (p-toluenesulfonyl) -14β-methylmarcfortine B;   1-ethyl-14β-methylmarcfortine B;   1-benzyl-14β-methylmarcfortine B;   18a-ethyl-14β-methylmarcfortine B;   18a-benzyl-14β-methylmarcfortine B;   18a-methoxyethoxymethyl-14β-methylmarcfortine B;   18a-allyl-14β-methylmarcfortine B;   18a-propargyl-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14β-methylmarkol Chin B;   1,18a-bis-ethyl-14β-methylmarcfortine B;   1,18a-bis-benzyl-14β-methylmarcfortine B;   18a-ethyl-24-methoxy-14β-methylmarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14β-methylmarcfortine B;   18a-ethyl-24,25-dihydro-14β-methylmarcfortine B;   24,25-dihydro-14β-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14β-methylmarcfortine C;   1-propionyl-14β-methylmarcfortine C;   1-propyl-14β-methylmarcfortine C;   1-benzyl-14β-methylmarcfortine C;   18a-propyl-14β-methylmarcfortine C;   18a-benzyl-14β-methylmarcfortine C;   18a-methoxyethoxymethyl-14β-methylmarcfortine C;   18-allyl-14β-methylmarcfortine C;   18a-propargyl-14β-methylmarcfortine C;   1,18a-bis-propyl-14β-methylmarcfortine C;   1,18a-bis-benzyl-14β-methylmarcfortine C;   14β-methylmarcfortine C;   1-palmitoyl-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14β-methylmarcfortine A;   1-palmitoyl-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14β-methylmarcfortine D;   14β-methylmarcfortine D;   1-acetoxymethyl-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14β-methylmarcfortine D;   1-dimethylsulfamoyl-14β-methylmarcfortine D;   1-cyclopropylcarbonyl-14β-methylmarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14β-methylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14β-methylmarcfortine D;   1-succinoyl-14β-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14β-methylmarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14β-methylmarcfortine D;   24-propoxy-24,25-dihydro-14β-methylmarcfortine D;   1- (p-toluenesulfonyl) -14β-methylmarcfortine D;   1-acetyl-14β-methylmarcfortine D;   1-methyl-14β-methylmarcfortine D;   1-benzyl-14β-methylmarcfortine D;   1-dimethylcarbamoyl-14β-methylmarcfortine D;   1-methoxycarbonyl-14β-methylmarcfortine D;   1-acetoxymethyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14β-ethylmarcfortine A;   1-dimethylsulfamoyl-14β-ethylmarcfortine A;   1-cyclopropylcarbonyl-14β-ethylmarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14β-ethylmarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14β-ethylmarcfortine A;   1-succinoyl-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14β-ethylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14β-ethylmarcfortine A;   24-propoxy-24,25-dihydro-14β-ethylmarcfortine A;   1- (p-toluenesulfonyl) -14β-ethylmarcfortine A;   1-acetyl-14β-ethylmarcfortine A;   1-methyl-14β-ethylmarcfortine A;   1-benzyl-14β-ethylmarcfortine A;   1-dimethylcarbamoyl-14β-ethylmarcfortine A;   1-methoxycarbonyl-14β-ethylmarcfortine A;   14β-ethylmarcfortine B;   24,25-dihydro-14β-ethylmarcfortine B;   24-methoxy-24,25-dihydro-14β-ethylmarcfortine B;   1- (p-toluenesulfonyl) -14β-ethylmarcfortine B;   1-ethyl-14β-ethylmarcfortine B;   1-benzyl-14β-ethylmarcfortine B;   18a-ethyl-14β-ethylmarcfortine B;   18a-benzyl-14β-ethylmarcfortine B;   18a-methoxyethoxymethyl-14β-ethylmarcfortine B;   18a-allyl-14β-ethylmarcfortine B;   18a-propargyl-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14β-ethylmarkol Chin B;   1,18a-bis-ethyl-14β-ethylmarcfortine B;   1,18a-bis-benzyl-14β-ethylmarcfortine B;   18a-ethyl-24-methoxy-14β-ethylmarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14β-ethylmarcfortine B;   18a-ethyl-24,25-dihydro-14β-ethylmarcfortine B;   24,25-dihydro-14β-ethylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14β-ethylmarcfortine C;   1-propionyl-14β-ethylmarcfortine C;   1-propyl-14β-ethylmarcfortine C;   1-benzyl-14β-ethylmarcfortine C;   18a-propyl-14β-ethylmarcfortine C;   18a-benzyl-14β-ethylmarcfortine C;   18a-methoxyethoxymethyl-14β-ethylmarcfortine C;   18-allyl-14β-ethylmarcfortine C;   18a-propargyl-14β-ethylmarcfortine C;   1,18a-bis-propyl-14β-ethylmarcfortine C;   1,18a-bis-benzyl-14β-ethylmarcfortine C;   14β-ethylmarcfortine C;   1-palmitoyl-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14β-ethylmarcfortine A;   1-palmitoyl-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14β-ethylmarcfortine D;   14β-ethylmarcfortine D;   1-acetoxymethyl-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14β-ethylmarcfortine D;   1-dimethylsulfamoyl-14β-ethylmarcfortine D;   1-cyclopropylcarbonyl-14β-ethylmarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14β-ethylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14β-ethylmarcfortine D;   1-succinoyl-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14β-ethylmarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14β-ethylmarcfortine D;   24-propoxy-24,25-dihydro-14β-ethylmarcfortine D;   1- (p-toluenesulfonyl) -14β-ethylmarcfortine D;   1-acetyl-14β-ethylmarcfortine D;   1-methyl-14β-ethylmarcfortine D;   1-benzyl-14β-ethylmarcfortine D;   1-dimethylcarbamoyl-14β-ethylmarcfortine D;   1-methoxycarbonyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14β-O-methylmarcfortine A;   14α-O-methylmarcfortine A;   14α-O-methyl-14β-methylmarcfortine A;   14α-O-methyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-O-methylmarcfortine A;   1-dimethylsulfamoyl-14α-O-methylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-methylmarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-methylmarcfortine A;   1- (1-Piperidinyl) thiocarbonyl-14α-O-methylmarcfortine A ;   1-succinoyl-14α-O-methylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-O-methylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methylmarkholch A;   24-propoxy-24,25-dihydro-14α-O-methylmarcfortine A;   1- (p-toluenesulfonyl) -14α-O-methylmarcfortine A;   1-acetyl-14α-O-methylmarcfortine A;   1-methyl-14α-O-methylmarcfortine A;   1-benzyl-14α-O-methylmarcfortine A;   1-dimethylcarbamoyl-14α-O-methylmarcfortine A;   1-methoxycarbonyl-14α-O-methylmarcfortine A;   14α-O-methylmarcfortine B;   24,25-dihydro-14α-O-methylmarcfortine B;   24-methoxy-24,25-dihydro-14α-O-methylmarcfortine B;   1- (p-toluenesulfonyl) -14α-O-methylmarcfortine B;   1-ethyl-14α-O-methylmarcfortine B;   1-benzyl-14α-O-methylmarcfortine B;   18a-ethyl-14α-O-methylmarcfortine B;   18a-benzyl-14α-O-methylmarcfortine B;   18a-methoxyethoxymethyl-14α-O-methylmarcfortine B;   18a-allyl-14α-O-methylmarcfortine B;   18a-propargyl-14α-O-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-methylmark Hortin B;   1,18a-bis-ethyl-14α-O-methylmarcfortine B;   1,18a-bis-benzyl-14α-O-methylmarcfortine B;   18a-ethyl-24-methoxy-14α-O-methylmarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-methylmarcfortine B;   18a-ethyl-24,25-dihydro-14α-O-methylmarcfortine B;   24,25-dihydro-14α-O-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-methylmarcfortine C;   1-propionyl-14α-O-methylmarcfortine C;   1-propyl-14α-O-methylmarcfortine C;   1-benzyl-14α-O-methylmarcfortine C;   18a-propyl-14α-O-methylmarcfortine C;   18a-benzyl-14α-O-methylmarcfortine C;   18a-methoxyethoxymethyl-14α-O-methylmarcfortine C;   18-allyl-14α-O-methylmarcfortine C;   18a-propargyl-14α-O-methylmarcfortine C;   1,18a-bis-propyl-14α-O-methylmarcfortine C;   1,18a-bis-benzyl-14α-O-methylmarcfortine C;   14α-O-methylmarcfortine C;   1-palmitoyl-14α-O-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-methylmarcfortine A;   1-palmitoyl-14α-O-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-methylmarcfortine D;   14α-O-methylmarcfortine D;   1-acetoxymethyl-14α-O-methylmarcfortine D;   1-diethoxyphosphoryl-14α-O-methylmarcfortine D;   1-dimethylsulfamoyl-14α-O-methylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-methylmarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-methylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-O-methylmarcfortine D ;   1-succinoyl-14α-O-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14α-O-methylmarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methylmarkholch D;   24-propoxy-24,25-dihydro-14α-O-methylmarcfortine D;   1- (p-toluenesulfonyl) -14α-O-methylmarcfortine D;   1-acetyl-14α-O-methylmarcfortine D;   1-methyl-14α-O-methylmarcfortine D;   1-benzyl-14α-O-methylmarcfortine D;   1-dimethylcarbamoyl-14α-O-methylmarcfortine D;   1-methoxycarbonyl-14α-O-methylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-methylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-methyl-14β-methylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-methylmarcfortine A;   1-Cyclopropylcarbonyl-14α-O-methyl-14β-methylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-methylmar Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-methylmer Lukhortin A;   1-succinoyl-14α-O-methyl-14β-methylmarcfortine A;   1- (4-morpholinosulfenyl) -14α-O-methyl-14β-methylmark E Rutin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-methyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-methylmarkol Chin A;   1-acetyl-14α-O-methyl-14β-methylmarcfortine A;   1-methyl-14α-O-methyl-14β-methylmarcfortine A;   1-benzyl-14α-O-methyl-14β-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-methyl-14β-methylmarcfortine A ;   1-methoxycarbonyl-14α-O-methyl-14β-methylmarcfortine A;   14α-O-methyl-14β-methylmarcfortine B;   24,25-dihydro-14α-O-methyl-14β-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-methyl-14β-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-methylmarkol Chin B;   1-ethyl-14α-O-methyl-14β-methylmarcfortine B;   1-benzyl-14α-O-methyl-14β-methylmarcfortine B;   18a-ethyl-14α-O-methyl-14β-methylmarcfortine B;   18a-benzyl-14α-O-methyl-14β-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-methylmarkol Chin B;   18a-allyl-14α-O-methyl-14β-methylmarcfortine B;   18a-propargyl-14α-O-methyl-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-methyl-14β -Methylmarcfortine B;   1,18a-bis-ethyl-14α-O-methyl-14β-methylmarcfortine B;   1,18a-bis-benzyl-14α-O-methyl-14β-methylmarcfortine B ;   18a-Ethyl-24-methoxy-14α-O-methyl-14β-methylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-methyl-14β-methylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-methyl-14β-methylmark Hortin B;   24,25-dihydro-14α-O-methyl-14β-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-methyl-14β-methylmar Kuhortin C;   1-propionyl-14α-O-methyl-14β-methylmarcfortine C;   1-propyl-14α-O-methyl-14β-methylmarcfortine C;   1-benzyl-14α-O-methyl-14β-methylmarcfortine C;   18a-propyl-14α-O-methyl-14β-methylmarcfortine C;   18a-benzyl-14α-O-methyl-14β-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-methylmarkol Chin C;   18-allyl-14α-O-methyl-14β-methylmarcfortine C;   18a-propargyl-14α-O-methyl-14β-methylmarcfortine C;   1,18a-bis-propyl-14α-O-methyl-14β-methylmarcfortine C ;   1,18a-bis-benzyl-14α-O-methyl-14β-methylmarcfortine C ;   14α-O-methyl-14β-methylmarcfortine C;   1-palmitoyl-14α-O-methyl-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-methylmarkho Rutin A;   1-palmitoyl-14α-O-methyl-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-methylmarkho Le Chin D;   14α-O-methyl-14β-methylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14α-O-methyl-14β-methylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-methylmarcfortine D;   1-Cyclopropylcarbonyl-14α-O-methyl-14β-methylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-methylmar Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-methylmer Lukhortin D;   1-succinoyl-14α-O-methyl-14β-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14α-O-methyl-14β-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-methyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-methylmarkol Chin D;   1-acetyl-14α-O-methyl-14β-methylmarcfortine D;   1-methyl-14α-O-methyl-14β-methylmarcfortine D;   1-benzyl-14α-O-methyl-14β-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-O-methyl-14β-ethylmarcfortine D ;   1-methoxycarbonyl-14α-O-methyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-ethylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-methyl-14β-ethylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-ethylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-methyl-14β-ethylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-ethylmal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-ethylmer Lukhortin A;   1-succinoyl-14α-O-methyl-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-O-methyl-14β-ethylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-ethyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-ethylmal Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-ethylmarkol Chin A;   1-acetyl-14α-O-methyl-14β-ethylmarcfortine A;   1-methyl-14α-O-methyl-14β-ethylmarcfortine A;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-methyl-14β-ethylmarcfortine A ;   1-methoxycarbonyl-14α-O-methyl-14β-ethylmarcfortine A;   14α-O-methyl-14β-ethylmarcfortine B;   24,25-dihydro-14α-O-methyl-14β-ethylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-methyl-14β-ethylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-ethylmarkol Chin B;   1-ethyl-14α-O-methyl-14β-ethylmarcfortine B;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-ethyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-benzyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-ethylmarkol Chin B;   18a-allyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-propargyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-methyl-14β -Ethylmarcfortine B;   1,18a-bis-ethyl-14α-O-methyl-14β-ethylmarcfortine B;   1,18a-bis-benzyl-14α-O-methyl-14β-ethylmarcfortine B ;   18a-ethyl-24-methoxy-14α-O-methyl-14β-ethylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-methyl-14β-ethylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-methyl-14β-ethylmark Hortin B;   24,25-dihydro-14α-O-methyl-14β-ethylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-methyl-14β-ethylmal Kuhortin C;   1-propionyl-14α-O-methyl-14β-ethylmarcfortine C;   1-propyl-14α-O-methyl-14β-ethylmarcfortine C;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-propyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-benzyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-ethylmarkol Chin C;   18-allyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-propargyl-14α-O-methyl-14β-ethylmarcfortine C;   1,18a-bis-propyl-14α-O-methyl-14β-ethylmarcfortine C ;   1,18a-bis-benzyl-14α-O-methyl-14β-ethylmarcfortine C ;   14α-O-methyl-14β-ethylmarcfortine C;   1-palmitoyl-14α-O-methyl-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-ethylmarkho Rutin A;   1-palmitoyl-14α-O-methyl-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-ethylmarkho Rutin D;   14α-O-methyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14α-O-methyl-14β-ethylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-ethylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-methyl-14β-ethylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-ethylmal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-ethylmer Lukhortin D;   1-succinoyl-14α-O-methyl-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-O-methyl-14β-ethylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-ethyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-ethylmal Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-ethylmarkol Chin D;   1-acetyl-14α-O-methyl-14β-ethylmarcfortine D;   1-methyl-14α-O-methyl-14β-ethylmarcfortine D;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-allyl marcfortine A;   14α-O-allyl marcfortine A;   14α-O-allyl-14β-methylmarcfortine A;   14α-O-allyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-O-allyl marcfortine A;   1-dimethylsulfamoyl-14α-O-allyl marcfortine A;   1-cyclopropylcarbonyl-14α-O-allyl marcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-allyl marcfortine A;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl marcfortine A ;   1-succinoyl-14α-O-allyl marcfortine A;   1- (4-morpholino sulphenyl) -14α-O-allyl marcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allylmarkholch A;   24-propoxy-24,25-dihydro-14α-O-allyl marcfortine A;   1- (p-toluenesulfonyl) -14α-O-allyl marcfortine A;   1-acetyl-14α-O-allyl marcfortine A;   1-methyl-14α-O-allyl marcfortine A;   1-benzyl-14α-O-allyl marcfortine A;   1-dimethylcarbamoyl-14α-O-allyl marcfortine A;   1-methoxycarbonyl-14α-O-allyl marcfortine A;   14α-O-allyl marcfortine B;   24,25-dihydro-14α-O-allyl marcfortine B;   24-methoxy-24,25-dihydro-14α-O-allyl marcfortine B;   1- (p-toluenesulfonyl) -14α-O-allyl marcfortine B;   1-ethyl-14α-O-allyl marcfortine B;   1-benzyl-14α-O-allyl marcfortine B;   18a-ethyl-14α-O-allyl marcfortine B;   18a-benzyl-14α-O-allyl marcfortine B;   18a-methoxyethoxymethyl-14α-O-allyl marcfortine B;   18a-allyl-14α-O-allyl marcfortine B;   18a-propargyl-14α-O-allylmarkottin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-allylmark Hortin B;   1,18a-bis-ethyl-14α-O-allyl marcfortine B;   1,18a-bis-benzyl-14α-O-allyl marcfortine B;   18a-Ethyl-24-methoxy-14α-O-allyl marcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-allyl marcfortine B;   18a-ethyl-24,25-dihydro-14α-O-allylmarkottin B;   24,25-dihydro-14α-O-allyl marcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-allyl marcfortine C;   1-propionyl-14α-O-allyl marcfortine C;   1-propyl-14α-O-allyl marcfortine C;   1-benzyl-14α-O-allyl marcfortine C;   18a-propyl-14α-O-allyl marcfortine C;   18a-benzyl-14α-O-allyl marcfortine C;   18a-methoxyethoxymethyl-14α-O-allyl marcfortine C;   18-allyl-14α-O-allyl marcfortine C;   18a-propargyl-14α-O-allyl marcfortine C;   1,18a-bis-propyl-14α-O-allyl marcfortine C;   1,18a-bis-benzyl-14α-O-allyl marcfortine C;   14α-O-allyl marcfortine C;   1-palmitoyl-14α-O-allyl marcfortine A;   1- (4-morpholinocarbonyl) -14α-O-allyl marcfortine A;   1-palmitoyl-14α-O-allyl marcfortine D;   1- (4-morpholinocarbonyl) -14α-O-allyl marcfortine D;   14α-O-allyl marcfortine D;   1-acetoxymethyl-14α-O-allyl marcfortine D;   1-diethoxyphosphoryl-14α-O-allyl marcfortine D;   1-dimethylsulfamoyl-14α-O-allylmarkottin D;   1-cyclopropylcarbonyl-14α-O-allyl marcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-allyl marcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl marcfortine D ;   1-succinoyl-14α-O-allyl marcfortine D;   1- (4-morpholinosulphenyl) -14α-O-allyl marcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allylmarkholch D;   24-propoxy-24,25-dihydro-14α-O-allyl marcfortine D;   1- (p-toluenesulfonyl) -14α-O-allyl marcfortine D;   1-acetyl-14α-O-allyl marcfortine D;   1-methyl-14α-O-allyl marcfortine D;   1-benzyl-14α-O-allyl marcfortine D;   1-dimethylcarbamoyl-14α-O-allyl marcfortine D;   1-methoxycarbonyl-14α-O-allyl marcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-methylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-allyl-14β-methylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-methylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-allyl-14β-methylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-methylmar Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-methylmer Lukhortin A;   1-succinoyl-14α-O-allyl-14β-methylmarcfortine A;   1- (4-morpholinosulfenyl) -14α-O-allyl-14β-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-methyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-methylmarkol Chin A;   1-acetyl-14α-O-allyl-14β-methylmarcfortine A;   1-methyl-14α-O-allyl-14β-methylmarcfortine A;   1-benzyl-14α-O-allyl-14β-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-allyl-14β-methylmarcfortine A ;   1-methoxycarbonyl-14α-O-allyl-14β-methylmarcfortine A;   14α-O-allyl-14β-methylmarcfortine B;   24,25-dihydro-14α-O-allyl-14β-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-allyl-14β-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-methylmarkol Chin B;   1-ethyl-14α-O-allyl-14β-methylmarcfortine B;   1-benzyl-14α-O-allyl-14β-methylmarcfortine B;   18a-ethyl-14α-O-allyl-14β-methylmarcfortine B;   18a-benzyl-14α-O-allyl-14β-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-methylmarkol Chin B;   18a-allyl-14α-O-allyl-14β-methylmarcfortine B;   18a-propargyl-14α-O-allyl-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-allyl-14β -Methylmarcfortine B;   1,18a-bis-ethyl-14α-O-allyl-14β-methylmarcfortine B;   1,18a-bis-benzyl-14α-O-allyl-14β-methylmarcfortine B ;   18a-Ethyl-24-methoxy-14α-O-allyl-14β-methylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-allyl-14β-methylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-allyl-14β-methylmark Hortin B;   24,25-dihydro-14α-O-allyl-14β-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-allyl-14β-methylmar Kuhortin C;   1-propionyl-14α-O-allyl-14β-methylmarcfortine C;   1-propyl-14α-O-allyl-14β-methylmarcfortine C;   1-benzyl-14α-O-allyl-14β-methylmarcfortine C;   18a-propyl-14α-O-allyl-14β-methylmarcfortine C;   18a-benzyl-14α-O-allyl-14β-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-methylmarkol Chin C;   18-allyl-14α-O-allyl-14β-methylmarcfortine C;   18a-propargyl-14α-O-allyl-14β-methylmarcfortine C;   1,18a-bis-propyl-14α-O-allyl-14β-methylmarcfortine C ;   1,18a-bis-benzyl-14α-O-allyl-14β-methylmarcfortine C ;   14α-O-allyl-14β-methylmarcfortine C;   1-palmitoyl-14α-O-allyl-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-methylmarkho Rutin A;   1-palmitoyl-14α-O-allyl-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-methylmarkho Rutin D;   14α-O-allyl-14β-methylmarcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14α-O-allyl-14β-methylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-methylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-allyl-14β-methylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-methylmar Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-methylmer Lukhortin D;   1-succinoyl-14α-O-allyl-14β-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14α-O-allyl-14β-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-methyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-methylmarkol Chi D;   1-acetyl-14α-O-allyl-14β-methylmarcfortine D;   1-methyl-14α-O-allyl-14β-methylmarcfortine D;   1-benzyl-14α-O-allyl-14β-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-O-allyl-14β-ethylmarcfortine D ;   1-methoxycarbonyl-14α-O-allyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-ethylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-allyl-14β-ethylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-ethylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-allyl-14β-ethylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-ethylmal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-ethylmer Lukhortin A;   1-succinoyl-14α-O-allyl-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-O-allyl-14β-ethylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-ethyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-ethylmal Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-ethylmarkol Chin A;   1-acetyl-14α-O-allyl-14β-ethylmarcfortine A;   1-methyl-14α-O-allyl-14β-ethylmarcfortine A;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-allyl-14β-ethylmarcfortine A ;   1-methoxycarbonyl-14α-O-allyl-14β-ethylmarcfortine A;   14α-O-allyl-14β-ethylmarcfortine B;   24,25-dihydro-14α-O-allyl-14β-ethylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-allyl-14β-ethylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-ethylmarkol Chin B;   1-ethyl-14α-O-allyl-14β-ethylmarcfortine B;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-ethyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-benzyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-ethylmarkol Chin B;   18a-allyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-propargyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-allyl-14β -Ethylmarcfortine B;   1,18a-bis-ethyl-14α-O-allyl-14β-ethylmarcfortine B;   1,18a-bis-benzyl-14α-O-allyl-14β-ethylmarcfortine;   18a-Ethyl-24-methoxy-14α-O-allyl-14β-ethylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-allyl-14β-ethylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-allyl-14β-ethylmark Hortin B;   24,25-dihydro-14α-O-allyl-14β-ethylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-allyl-14β-ethylmal Ku Hortin C;   1-propionyl-14α-O-allyl-14β-ethylmarcfortine C;   1-propyl-14α-O-allyl-14β-ethylmarcfortine C;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-propyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-benzyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-ethylmarkol Chin C;   18-allyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-propargyl-14α-O-allyl-14β-ethylmarcfortine C;   1,18a-Bis-propyl-14α-O-allyl-14β-ethylmarcfortine C ;   1,18a-bis-benzyl-14α-O-allyl-14β-ethylmarcfortine C ;   14α-O-allyl-14β-ethylmarcfortine C;   1-palmitoyl-14α-O-allyl-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-ethylmarkho Rutin A;   1-palmitoyl-14α-O-allyl-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-ethylmarkho Rutin D;   14α-O-allyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-ethylmanorecfortine D;   1-diethoxyphosphoryl-14α-O-allyl-14β-ethylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-ethylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-allyl-14β-ethylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-ethylmal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-ethylmer Lukhortin D;   1-succinoyl-14α-O-allyl-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-O-allyl-14β-ethylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-ethyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-ethylmal Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-ethylmarkol Chin D;   1-acetyl-14α-O-allyl-14β-ethylmarcfortine D;   1-methyl-14α-O-allyl-14β-ethylmarcfortine D;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine D;   14α-hydroxy-14β-methyl-15α-methylmarcfortine A;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Rumarkfortin A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Tilmarkfortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methylmarcfortine A;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methylmarcfortine A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Tilmarkfortin A;   1-Acetyl-14α-hydroxy-14β-methyl-15α-methylmarkholch A;   1-Methyl-14α-hydroxy-14β-methyl-15α-methylmarcfortine A;   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine A;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methylmer Lukhortin A;   14α-hydroxy-14β-methyl-15α-methylmarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methylmark Hortin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methylmarcfortine B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Tilmarkfortin B;   1-Ethyl-14α-hydroxy-14β-methyl-15α-methylmarcfortine B;   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch B   18a-Ethyl-14α-hydroxy-14β-methyl-15α-methylmarkol Chin B;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl marcfortine B;   18a-allyl-14α-hydroxy-14β-methyl-15α-methylmarkol Chin B;   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methyl-15α-methylmarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-methyl-15α-methylmer Lukhortin B;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methyl-15α-me Tilmarkfortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methylmarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methylmark Hortin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-14β-methyl-1 5α-methylmarcfortine C;   1-propionyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin C;   1-Propyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   18a-Propyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin C;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl marcfortine C;   18-allyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin C;   1,18a-Bis-propyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine C;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine C;   14α-hydroxy-14β-methyl-15α-methylmarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-14 α-hydroxy-14β-methyl-15α-methylmarcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl marcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl marcfortine D;   14α-hydroxy-14β-methyl-15α-methylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Lemarc Hortin D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Tilmarkfortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methylmarcfortine D;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methyl marcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methylmarcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Tilmarkfortin D;   1-Acetyl-14α-hydroxy-14β-methyl-15α-methylmarkholch D;   1-Methyl-14α-hydroxy-14β-methyl-15α-methylmarcfortine D;   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch D;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine D;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methylmer Lukhortin D;   14α-hydroxy-15α-methylmarcfortine A;   1-acetoxymethyl-14α-hydroxy-15α-methylmarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-15α-methylxymarkol Chin A;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methylmarkholch A;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methylmarkol Chin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methylmer Lukhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methylmer Lukhortin A;   1-succinoyl-14α-hydroxy-15α-methylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Tilmarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methylmarkol Chi A;   1-acetyl-14α-hydroxy-15α-methylmarcfortine A;   1-methyl-14α-hydroxy-15α-methylmarcfortine A;   1-benzyl-14α-hydroxy-15α-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methylmarcfortine A;   1-Methoxycarbonyl-14α-hydroxy-15α-methylmarcfortine A ;   14α-hydroxy-15α-methylmarcfortine B;   24,25-dihydro-14α-hydroxy-15α-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-15α-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methylmarkol Chin B;   1-ethyl-14α-hydroxy-15α-methylmarcfortine B;   1-benzyl-14α-hydroxy-15α-methylmarcfortine B;   18a-ethyl-14α-hydroxy-15α-methylmarcfortine B;   18a-benzyl-14α-hydroxy-15α-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methylmarkho Rutin B;   18a-allyl-14α-hydroxy-15α-methylmarcfortine B;   18a-propargyl-14α-hydroxy-15α-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-15 α-methylmarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-15α-methylmarcfortine B ;   1,18a-Bis-benzyl-14α-hydroxy-15α-methylmarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-15α-methylmarkol Chin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-15α-methylmark Hortin B;   24,25-dihydro-14α-hydroxy-15α-methylmarcfortine C;   1- (p-Bromobenzenesulfonyl) -14α-hydroxy-15α-methylmar Kuhortin C;   1-propionyl-14α-hydroxy-15α-methylmarcfortine C;   1-propyl-14α-hydroxy-15α-methylmarcfortine C;   1-benzyl-14α-hydroxy-15α-methylmarcfortine C;   18a-propyl-14α-hydroxy-15α-methylmarcfortine C;   18a-benzyl-14α-hydroxy-15α-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methylmarkho Rutin C;   18-allyl-14α-hydroxy-15α-methylmarcfortine C;   18a-propargyl-14α-hydroxy-15α-methylmarcfortine C;   1,18a-Bis-propyl-14α-hydroxy-15α-methylmarcfortine C;   1,18a-Bis-benzyl-14α-hydroxy-15α-methylmarcfortine C;   14α-hydroxy-15α-methylmarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-15α-methylmarcfortine A;   1-palmitoyl-14α-hydroxy-15α-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methylmarkho Rutin A;   1-palmitoyl-14α-hydroxy-15α-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methylmark Hol Chin D;   14α-hydroxy-15α-methylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-15α-methylmarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-15α-methylmarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methylmarkholch D;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methylmarkol Chin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methylmer Lukhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methylmer Lukhortin D;   1-succinoyl-14α-hydroxy-15α-methylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Tilmarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methylmarkol Chin D;   1-acetyl-14α-hydroxy-15α-methylmarcfortine D;   1-methyl-14α-hydroxy-15α-methylmarcfortine D;   1-benzyl-14α-hydroxy-15α-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methylmarcfortine D;   1-methoxycarbonyl-14α-hydroxy-15α-methylmarcfortine D .   The novel compounds of the present invention are, for example, 14α-hydroxymarcfortine A (formula 10, chart A), 14α-hydroxy-14β-methylmarcfortine A (formula 15, chart C), 14β-hydroxymarcfortine A (formula 17, chart) D), 14α-hydroxymarcfortine A N-oxide (Formula 18, Chart D ), 14α-hydroxy-14β-ethylmarcfortine A (Formula 19, Chart D ), 14β-Methylmarcfortine A, 14α-hydroxy-14β-methyl-15 α-Methylmarcfortine A, 14α-Hydroxy-15α-methylmarcfortine The following chemical reactions applicable to the production of A and their precursors (Charts AG) Manufacture according to   The novel compounds of this invention are made by the following methods:   Surprisingly, marcfortine A, B, C and D, or their suitable Substituted C-24, C-25, N-1 and N-18a derivatives with cyanogen iodide Then, a means for producing the compound of the present invention illustrated in Chart A may be provided. found.   Another aspect of the invention is the novel intermediates prepared according to Charts AG. And includes the following:   16-iodo-17-cyanomarcfortine A;   1-acetoxymethyl-16-iodo-17-cyanomarcfortine A;   1-diethoxyphosphoryl-16-iodo-17-cyanomarcfortine A;   1-dimethylsulfamoyl-16-iodo-17-cyanomarcfortine A;   1-cyclopropylcarbonyl-16-iodo-17-cyanomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-16-iodo-17-cyanomarkol Chin A;   1- (1-piperidinyl) thiocarbonyl-16-iodo-17-cyanomarkol Chin A;   1-succinoyl-16-iodo-17-cyanomarcfortine A;   1- (4-morpholinosulphenyl) -16-iodo-17-cyanomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -16-iodo-17-cyanomal Ku Hortin A;   24-propoxy-24,25-dihydro-16-iodo-17-cyanomarkholch A;   1- (p-toluenesulfonyl) -16-iodo-17-cyanomarcfortine A;   1-acetyl-16-iodo-17-cyanomarcfortine A;   1-methyl-16-iodo-17-cyanomarcfortine A;   1-benzyl-16-iodo-17-cyanomarcfortine A;   1-dimethylcarbamoyl-16-iodo-17-cyanomarcfortine A;   1-methoxycarbonyl-16-iodo-17-cyanomarcfortine A;   16-iodo-17-cyanomarcfortine B;   24,25-dihydro-16-iodo-17-cyanomarcfortine B;   24-Methoxy-24,25-dihydro-16-iodo-17-cyanomarcfortine B;   1- (p-toluenesulfonyl) -16-iodo-17-cyanomarcfortine B;   1-ethyl-16-iodo-17-cyanomarcfortine B;   1-benzyl-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-16-iodo-17-cyanomarcfortine B;   18a-benzyl-16-iodo-17-cyanomarcfortine B;   18a-Methoxyethoxymethyl-16-iodo-17-cyanomarcfortine B ;   18a-allyl-16-iodo-17-cyanomarcfortine B;   18a-propargyl-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-16-iodo-17-cyano Marcfortine B;   1,18a-bis-ethyl-16-iodo-17-cyanomarcfortine B;   1,18a-bis-benzyl-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-24-methoxy-16-iodo-17-cyanomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-24,25-dihydro-16-iodo-17-cyanomarcfortine B;   24,25-dihydro-16-iodo-17-cyanomarcfortine C;   1- (p-bromobenzenesulfonyl) -16-iodo-17-cyanomarcforty C   1-propionyl-16-iodo-17-cyanomarcfortine C;   1-propyl-16-iodo-17-cyanomarcfortine C;   1-benzyl-16-iodo-17-cyanomarcfortine C;   18a-Propyl-16-iodo-17-cyanomarcfortine C;   18a-benzyl-16-iodo-17-cyanomarcfortine C;   18a-Methoxyethoxymethyl-16-iodo-17-cyanomarcfortine C ;   18-allyl-16-iodo-17-cyanomarcfortine C;   18a-propargyl-16-iodo-17-cyanomarcfortine C;   1,18a-bis-propyl-16-iodo-17-cyanomarcfortine C;   1,18a-bis-benzyl-16-iodo-17-cyanomarcfortine C;   16-iodo-17-cyanomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-16- Iodo-17-cyanomarcfortine A;   1-palmitoyl-16-iodo-17-cyanomarcfortine A;   1- (4-morpholinocarbonyl) -16-iodo-17-cyanomarcfortine A ;   1-palmitoyl-16-iodo-17-cyanomarcfortine D;   1- (4-morpholinocarbonyl) -16-iodo-17-cyanomarcfortine D ;   16-iodo-17-cyanomarcfortine D;   1-acetoxymethyl-16-iodo-17-cyanomarcfortine D;   1-diethoxyphosphoryl-16-iodo-17-cyanomarcfortine D;   1-dimethylsulfamoyl-16-iodo-17-cyanomarcfortine D;   1-cyclopropylcarbonyl-16-iodo-17-cyanomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-16-iodo-17-cyanomarkol Chi D;   1- (1-piperidinyl) thiocarbonyl-16-iodo-17-cyanomarkol Chin D;   1-succinoyl-16-iodo-17-cyanomarcfortine D;   1- (4-morpholinosulphenyl) -16-iodo-17-cyanomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -16-iodo-17-cyanomal Kuhortin D;   24-propoxy-24,25-dihydro-16-iodo-17-cyanomarkholch D;   1- (p-toluenesulfonyl) -16-iodo 17-cyanomarcfortine D;   1-acetyl-16-iodo-17-cyanomarcfortine D;   1-methyl-16-iodo-17-cyanomarcfortine D;   1-benzyl-16-iodo-17-cyanomarcfortine D;   1-dimethylcarbamoyl-16-iodo-17-cyanomarcfortine D;   1-methoxycarbonyl-16-iodo-17-cyanomarcfortine D;   16,17-dehydro-17-cyanomarcfortine A;   1-acetoxymethyl-16,17-dehydro-17-cyanomarcfortine A;   1-diethoxyphosphoryl-16,17-dehydro-17-cyanomarcfortine A ;   1-Dimethylsulfamoyl-16,17-dehydro-17-cyanomarcfortine A;   1-cyclopropylcarbonyl-16,17-dehydro-17-cyanomarcforty A;   2-bicyclo [2. 2. 1] Heptanoyl-16,17-dehydro-17-cyanomal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-16,17-dehydro-17-cyanomer Lukhortin A;   1-succinoyl-16,17-dehydro-17-cyanomarcfortine A;   1- (4-morpholinosulphenyl) -16,17-dehydro-17-cyanomark E Rutin A;   1- (2,4-dinitrobenzenesulfenyl) -16,17-dehydro-17-sia Nomarc Hortin A;   24-propoxy-24,25-dihydro-16,17-dehydro-17-cyanomal Kuhortin A;   1- (p-toluenesulfonyl) -16,17-dehydro-17-cyanomarkol Chin A;   1-acetyl-16,17-dehydro-17-cyanomarcfortine A;   1-methyl-16,17-dehydro-17-cyanomarcfortine A;   1-benzyl-16,17-dehydro-17-cyanomarcfortine A;   1-dimethylcarbonyl-16,17-dehydro-17-cyanomarcfortine A;   1-methoxycarbonyl-16,17-dehydro-17-cyanomarcfortine A;   16,17-dehydro-17-cyanomarcfortine B;   24,25-dihydro-16,17-dehydro-17-cyanomarcfortine B;   24-Methoxy-24,25-dihydro-16,17-dehydro-17-cyanomark Hortin B;   1- (p-toluenesulfonyl) -16,17-dehydro-17-cyanomarkol Chin B;   1-ethyl-16,17-dehydro-17-cyanomarcfortine B;   1-benzyl-16,17-dehydro-cyanomarcfortine B;   18a-Ethyl-16,17-dehydro-17-cyanomarcfortine B;   18a-benzyl-16,17-dehydro-17-cyanomarcfortine B;   18a-methoxyethoxymethyl-16,17-dehydro-17-cyanomarkol Chin B;   18a-allyl-16,17-dehydro-17-cyanomarcfortine B;   18a-propargyl-16,17-dehydro-17-cyanomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-16,17-dehydro-17 -Cyanomarcfortine B;   1,18a-bis-ethyl-16,17-dehydro-17-cyanomarcfortine B;   1,18a-Bis-benzyl-16,17-dehydro-17-cyanomarcfortine B ;   18a-Ethyl-24-methoxy-16,17-dehydro-17-cyanomarcforty B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-16,17-dehydro-17-cyanomarcfortine B;   18a-Ethyl-24,25-dihydro-16,17-dehydro-17-cyanomark Hortin B;   24,25-dihydro-16,17-dehydro-17-cyanomarcfortine C;   1- (p-bromobenzenesulfonyl) -16,17-dehydro-17-cyanomal Kuhortin C;   1-propionyl-16,17-dehydro-17-cyanomarcfortine C;   1-propyl-16,17-dehydro-17-cyanomarcfortine C;   1-benzyl-16,17-dehydro-17-cyanomarcfortine C;   18a-propyl-16,17-dehydro-17-cyanomarcfortine C;   18a-benzyl-16,17-dehydro-17-cyanomarcfortine C;   18a-methoxyethoxymethyl-16,17-dehydro-17-cyanomarkol Chin C;   18-allyl-16,17-dehydro-17-cyanomarcfortine C;   18a-propargyl-16,17-dehydro-17-cyanomarcfortine C;   1,18a-bis-propyl-16,17-dehydro-17-cyanomarcfortine C ;   1,18a-Bis-benzyl-16,17-dehydro-17-cyanomarcfortine C ;   16,17-dehydro-17-cyanomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-16, 17-dehydro-17-cyanomarcfortine A;   1-palmitoyl-16,17-dehydro-17-cyanomarcfortine A;   1- (4-morpholinocarbonyl) -16,17-dehydro-17-cyanomarkho Rutin A;   1-palmitoyl-16,17-dehydro-17-cyanomarcfortine D;   1- (4-morpholinocarbonyl) -16,17-dehydro-17-cyanomarkho Rutin D;   16,17-dehydro-17-cyanomarcfortine D;   1-acetoxymethyl-16,17-dehydro-17-cyanomarcfortine D;   1-diethoxyphosphoryl-16,17-dehydro-17-cyanomarcfortine D ;   1-Dimethylsulfamoyl-16,17-dehydro-17-cyanomarcfortine D;   1-cyclopropylcarbonyl-16,17-dehydro-17-cyanomarcforty D;   2-bicyclo [2. 2. 1] Heptanoyl-16,17-dehydro-17-cyanomal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-16,17-dehydro-17-cyanomer Lukhortin D;   1-succinoyl-16,17-dehydro-17-cyanomarcfortine D;   1- (4-morpholinosulphenyl) -16,17-dehydro-17-cyanomark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -16,17-dehydro-17-sia Nomarc Hortin D;   24-propoxy-24,25-dihydro-16,17-dehydro-17-cyanomal Kuhortin D;   1- (p-toluenesulfonyl) -16,17-dehydro-17-cyanomarkol Chin D;   1-acetyl-16,17-dehydro-17-cyanomarcfortine D;   1-methyl-16,17-dehydro-17-cyanomarcfortine D;   1-benzyl-16,17-dehydro-17-cyanomarcfortine D;   1-Dimethylcarbamoyl-16,17-dehydro-17-cyanomarcfortine D ;   1-methoxycarbonyl-16,17-dehydro-17-cyanomarcfortine D;   17-ketomarkhortin A;   1-acetoxymethyl-17-ketomarcfortine A;   1-diethoxyphosphoryl-17-ketoxoxymarkottin A;   1-dimethylsulfamoyl-17-ketomarkfortin A;   1-cyclopropylcarbonyl-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-17-ketomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-17-ketomarcfortine A;   1-succinoyl-17-ketomarkfortin A;   1- (4-morpholinosulphenyl) -17-ketomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -17-ketomarcfortine A;   24-propoxy-24,25-dihydro-17-ketomarcfortine A;   1- (p-toluenesulfonyl) -17-ketomarcfortine A;   1-acetyl-17-ketomarcfortine A;   1-methyl-17-ketomarcfortine A;   1-benzyl-17-ketomarcfortine A;   1-dimethylcarbamoyl-17-ketomarcfortine A;   1-methoxycarbonyl-17-ketomarcfortine A;   17-ketomarkhortin B;   24,25-dihydro-17-ketomarcfortine B;   24-methoxy-24,25-dihydro-17-ketomarcfortine B;   1- (p-toluenesulfonyl) -17-ketomarcfortine B;   1-ethyl-17-ketomarcfortine B;   1-benzyl-17-ketomarcfortine B;   18a-ethyl-17-ketomarcfortine B;   18a-benzyl-17-ketomarcfortine B;   18a-methoxyethoxymethyl-17-ketomarcfortine B;   18a-allyl-17-ketomarcfortine B;   18a-propargyl-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-17-ketomarcfortine B;   1,18a-bis-ethyl-17-ketomarcfortine B;   1,18a-bis-benzyl-17-ketomarcfortine B;   18a-ethyl-24-methoxy-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-ethyl-24,25-dihydro-17-ketomarcfortine B;   24,25-dihydro-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -17-ketomarcfortine C;   1-propionyl-17-ketomarcfortine C;   1-propyl-17-ketomarcfortine C;   1-benzyl-17-ketomarcfortine C;   18a-propyl-17-ketomarcfortine C;   18a-benzyl-17-ketomarcfortine C;   18a-methoxyethoxymethyl-17-ketomarcfortine C;   18-allyl-17-ketomarcfortine C;   18a-propargyl-17-ketomarcfortine C;   1,18a-bis-propyl-17-ketomarcfortine C;   1,18a-bis-benzyl-17-ketomarcfortine C;   17-ketomarkhortin C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-17- Ketomarkhortin A;   1-palmitoyl-17-ketomarcfortine A;   1- (4-morpholinocarbonyl) -17-ketomarcfortine A;   1-palmitoyl-17-ketomarcfortine D;   1- (4-morpholinocarbonyl) -17-ketomarcfortine D;   17-ketodroxymarcfortine D;   1-acetoxymethyl-17-ketomarcfortine D;   1-diethoxyphosphoryl-17-ketomarcfortine D;   1-dimethylsulfamoyl-17-ketomarcfortine D;   1-cyclopropylcarbonyl-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-17-ketomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-17-ketomarcfortine D;   1-succinoyl-17-ketomarkfortin D;   1- (4-morpholinosulphenyl) -17-ketomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -17-ketomarcfortine D;   24-propoxy-24,25-dihydro-17-ketomarcfortine D;   1- (p-toluenesulfonyl) -17-ketomarcfortine D;   1-acetyl-17-ketomarcfortine D;   1-methyl-17-ketomarcfortine D;   1-benzyl-17-ketomarcfortine D;   1-dimethylcarbamoyl-17-ketomarcfortine D;   1-methoxycarbonyl-17-ketomarcfortine D;   15,16-dehydro-17-ketomarcfortine A;   1-acetoxymethyl-15,16-dehydro-17-ketomarcfortine A;   1-diethoxyphosphoryl-15,16-dehydro-17-ketomarcfortine A;   1-Dimethylsulfamoyl-15,16-dehydro-17-ketomarcfortine A ;   1-cyclopropylcarbonyl-15,16-dehydro-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-17-ketomark Hortin A;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-17-ketomal Kuhortin A;   1-succinoyl-15,16-dehydro-17-ketomarcfortine A;   1- (4-morpholinosulfenyl) -15,16-dehydro-17-ketomarcho Le Chin A;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-17-keto Marcfortine A;   24-propoxy-24,25-dihydro-15,16-dehydro-17-ketomark Hortin A;   1- (p-toluenesulfonyl) -15,16-dehydro-17-ketomarkholch A;   1-acetyl-15,16-dehydro-17-ketomarcfortine A;   1-methyl-15,16-dehydro-17-ketomarcfortine A;   1-benzyl-15,16-dehydro-17-ketomarcfortine A;   1-dimethylcarbamoyl-15,16-dehydro-17-ketomarcfortine A;   1-methoxycarbonyl-15,16-dehydro-17-ketomarcfortine A;   15,16-dehydro-17-ketomarcfortine B;   24,25-dihydro-15,16-dehydro-17-ketomarcfortine B;   24-Methoxy-24,25-dihydro-15,16-dehydro-17-ketomarcho Rutin B;   1- (p-toluenesulfonyl) -15,16-dehydro-17-ketomarkholch B   1-ethyl-15,16-dehydro-17-ketomarcfortine B;   1-benzyl-15,16-dehydro-ketomarcfortine B;   18a-Ethyl-15,16-dehydro-17-ketomarcfortine B;   18a-benzyl-15,16-dehydro-17-ketomarcfortine B;   18a-Methoxyethoxymethyl-15,16-dehydro-17-ketomarkholch B   18a-allyl-15,16-dehydro-17-ketomarcfortine B;   18a-propargyl-15,16-dehydro-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-15,16-dehydro-17 -Ketmarkhortin B;   1,18a-bis-ethyl-15,16-dehydro-17-ketomarcfortine B;   1,18a-bis-benzyl-15,16-dehydro-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-15,16-dehydro-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-15,16-dehydro-17-ketomarcho Rutin B;   24,25-dihydro-15,16-dehydro-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -15,16-dehydro-17-ketomark Hortin C;   1-propionyl-15,16-dehydro-17-ketomarcfortine C;   1-propyl-15,16-dehydro-17-ketomarcfortine C;   1-benzyl-15,16-dehydro-17-ketomarcfortine C;   18a-Propyl-15,16-dehydro-17-ketomarcfortine C;   18a-benzyl-15,16-dehydro-17-ketomarcfortine C;   18a-Methoxyethoxymethyl-15,16-dehydro-17-ketomarkholch C   18-allyl-15,16-dehydro-17-ketomarcfortine C;   18a-propargyl-15,16-dehydro-17-ketomarcfortine C;   1,18a-bis-propyl-15,16-dehydro-17-ketomarcfortine C;   1,18a-bis-benzyl-15,16-dehydro-17-ketomarcfortine C;   15,16-dehydro-17-ketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-15, 16-dehydro-17-ketomarcfortine A;   1-palmitoyl-15,16-dehydro-17-ketomarcfortine A;   1- (4-morpholinocarbonyl) -15,16-dehydro-17-ketomarkol Chin A;   1-palmitoyl-15,16-dehydro-17-ketomarcfortine D;   1- (4-morpholinocarbonyl) -15,16-dehydro-17-ketomarkol Chin D;   15,16-dehydro-17-ketomarcfortine D;   1-acetoxymethyl-15,16-dehydro-17-ketomarcfortine D;   1-diethoxyphosphoryl-15,16-dehydro-17-ketomarcfortine D;   1-dimethylsulfamoyl-15,16-dehydro-17-ketomarcfortine D ;   1-cyclopropylcarbonyl-15,16-dehydro-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-17-ketomark Hortin D;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-17-ketomal Kuhortin D;   1-succinoyl-15,16-dehydro-17-ketomarcfortine D;   1- (4-morpholinosulfenyl) -15,16-dehydro-17-ketomarcho Rutin D;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-17-keto Marcfortine D;   24-propoxy-24,25-dihydro-15,16-dehydro-17-ketomark Hortin D;   1- (p-toluenesulfonyl) -15,16-dehydro-17-ketomarkholch D;   1-acetyl-15,16-dehydro-17-ketomarcfortine D;   1-methyl-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-15,16-dehydro-17-ketomarcfortine D;   1-dimethylcarbamoyl-15,16-dehydro-17-ketomarcfortine D;   1-methoxycarbonyl-15,16-dehydro-17-ketomarcfortine D;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin A;   1-diethoxyphosphoryl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-15,16-dehydro-17-ke Tomarkfortin A;   1-cyclopropylcarbonyl-14α-hydroxy-15,16-dehydro-17- Ketomarkhortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15,16-dehi Doro-17-ketomarkhortin A;   1-succinoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinosulphenyl) -14α-hydroxy-15,16-dehydro- 17-ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15,16- Dehydro-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-15,16-dehydro-17 -Ketmarkhortin A;   1-Acetyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch A;   1-Methyl-14α-hydroxy-15,16-dehydro-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch A;   1-Dimethylcarbamoyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine A;   1-Methoxycarbonyl-14α-hydroxy-15,16-dehydro-17-ketomer Lukhortin A;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine B;   24,25-dihydro-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-15,16-dehydro- 17-ketomarkhortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-15,16-dehydro-17 -Ketmarkhortin B;   1-Ethyl-14α-hydroxy-15,16-dehydro-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch B   18a-Ethyl-14α-hydroxy-15,16-dehydro-17-ketomarkol Chin B;   18a-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkho Rutin B;   18a-Methoxyethoxymethyl-14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin B;   18a-allyl-14α-hydroxy-15,16-dehydro-17-ketomarkol Chin B;   18a-Propargyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin B;   18a-ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-15, 16-dehydro-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-15,16-dehydro-17-ketomer Lukhortin B;   1,18a-bis-benzyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-15,16-dehydro-17- Ketomarkhortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-15,16-dehydro- 17-ketomarkhortin B;   24,25-dihydro-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin C;   1-propionyl-14α-hydroxy-15,16-dehydro-17-ketomarkouf Rutin C;   1-propyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch C   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch C   18a-Propyl-14α-hydroxy-15,16-dehydro-17-ketomarkho Rutin C;   18a-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkho Rutin C;   18a-Methoxyethoxymethyl-14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin C;   18-allyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch C   18a-Propargyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin C;   1,18a-bis-propyl-14α-hydroxy-15,16-dehydro-17-ke Tomarkfortin C;   1,18a-bis-benzyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine C;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-15,16-dehydro-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin A;   1-palmitoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin D;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin D;   1-diethoxyphosphoryl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-15,16-dehydro-17-ke Tomarkfortin D;   1-cyclopropylcarbonyl-14α-hydroxy-15,16-dehydro-17- Ketomarkhortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15,16-dehi Do Ro-17-ketomarkhortin D;   1-succinoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinosulphenyl) -14α-hydroxy-15,16-dehydro- 17-ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15,16- Dehydro-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-15,16-dehydro-17 -Ketmarkhortin D;   1-Acetyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch D;   1-Methyl-14α-hydroxy-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch D;   1-Dimethylcarbamoyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine D;   1-Methoxycarbonyl-14α-hydroxy-15,16-dehydro-17-ketomer Lukhortin D;   14α-hydroxy-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-17-ketomarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-17-ketoxymarkfortin A;   1-Dimethylsulfamoyl-14α-hydroxy-17-ketomarcfortine A ;   1-Cyclopropylcarbonyl-14α-hydroxy-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-17-ketomark Hortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-17-ketomark Hortin A;   1-succinoyl-14α-hydroxy-17-ketomarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-17-ketomarkol Chin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-17-keto Marcfortine A;   24-propoxy-24,25-dihydro-14α-hydroxy-17-ketomarcho Rutin A;   1- (p-toluenesulfonyl) -14α-hydroxy-17-ketomarcfortine A;   1-acetyl-14α-hydroxy-17-ketomarcfortine A;   1-methyl-14α-hydroxy-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-17-ketomarcfortine A;   1-dimethylcarbamoyl-14α-hydroxy-17-ketomarcfortine A;   1-methoxycarbonyl-14α-hydroxy-17-ketomarcfortine A;   14α-hydroxy-17-ketomarcfortine B;   24,25-dihydro-14α-hydroxy-17-ketomarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-17-ketomarkol Chin B;   1- (p-toluenesulfonyl) -14α-hydroxy-17-ketomarcfortine B;   1-ethyl-14α-hydroxy-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-17-ketomarcfortine B;   18a-ethyl-14α-hydroxy-17-ketomarcfortine B;   18a-benzyl-14α-hydroxy-17-ketomarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-17-ketomarkholchti B   18a-allyl-14α-hydroxy-17-ketomarcfortine B;   18a-propargyl-14α-hydroxy-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-17- Ketomarkhortin B;   1,18a-bis-ethyl-14α-hydroxy-17-ketomarcfortine B;   1,18a-bis-benzyl-14α-hydroxy-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-17-ketomarkol Chin B;   24,25-dihydro-14α-hydroxy-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-17-ketomarkho Rutin C;   1-propionyl-14α-hydroxy-17-ketomarcfortine C;   1-propyl-14α-hydroxy-17-ketomarcfortine C;   1-benzyl-14α-hydroxy-17-ketomarcfortine C;   18a-propyl-14α-hydroxy-17-ketomarcfortine C;   18a-benzyl-14α-hydroxy-17-ketomarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-17-ketomarkholchti C   18-allyl-14α-hydroxy-17-ketomarcfortine C;   18a-propargyl-14α-hydroxy-17-ketomarcfortine C;   1,18a-bis-propyl-14α-hydroxy-17-ketomarcfortine C;   1,18a-bis-benzyl-14α-hydroxy-17-ketomarcfortine C;   14α-hydroxy-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α - Hydroxy-17-ketomarkfortin A;   1-palmitoyl-14α-hydroxy-17-ketomarkfortin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-17-ketomarcholch A;   1-palmitoyl-14α-hydroxy-17-ketomarkfortin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-17-ketomarcholch D;   14α-hydroxy-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-17-ketomarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-17-ketomarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-17-ketomarcfortine D ;   1-Cyclopropylcarbonyl-14α-hydroxy-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-17-ketomark Hortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-17-ketomark Hortin D;   1-succinoyl-14α-hydroxy-17-ketomarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-17-ketomarkol Chin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-17-keto Marcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-17-ketomarcho Rutin D;   1- (p-toluenesulfonyl) -14α-hydroxy-17-ketomarcfortine D;   1-acetyl-14α-hydroxy-17-ketomarcfortine D;   1-methyl-14α-hydroxy-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-17-ketomarcfortine D;   1-dimethylcarbamoyl-14α-hydroxy-17-ketomarcfortine D;   1-methoxycarbonyl-14α-hydroxy-17-ketomarcfortine D;   14,17-diketomarkottin A;   1-acetoxymethyl-14,17-diketomarkfortin A;   1-diethoxyphosphoryl-14,17-diketoxymarcfortine A;   1-dimethylsulfamoyl-14,17-diketomarkfortin A;   1-cyclopropylcarbonyl-14,17-diketomarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14,17-diketomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-14,17-diketomarcfortine A ;   1-succinoyl-14,17-diketomarkfortin A;   1- (4-morpholinosulphenyl) -14,17-diketomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14,17-diketomarkholch A;   24-propoxy-24,25-dihydro-14,17-diketomarcfortine A;   1- (p-toluenesulfonyl) -14,17-diketomarcfortine A;   1-acetyl-14,17-diketomarkfortin A;   1-methyl-14,17-diketomarcfortine A;   1-benzyl-14,17-diketomarcfortine A;   1-dimethylcarbamoyl-14,17-diketomarkfortin A;   1-methoxycarbonyl-14,17-diketomarcfortine A;   14,17-diketomarkfortin B;   24,25-dihydro-14,17-diketomarkfortin B;   24-methoxy-24,25-dihydro-14,17-diketomarcfortine B;   1- (p-toluenesulfonyl) -14,17-diketomarcfortine B;   1-ethyl-14,17-diketomarcfortine B;   1-benzyl-14,17-diketomarcfortine B;   18a-ethyl-14,17-diketomarkfortin B;   18a-benzyl-14,17-diketomarkfortin B;   18a-methoxyethoxymethyl-14,17-diketomarcfortine B;   18a-allyl-14,17-diketomarcfortine B;   18a-propargyl-14,17-diketomarkfortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14,17-diketomark Hortin B;   1,18a-bis-ethyl-14,17-diketomarcfortine B;   1,18a-bis-benzyl-14,17-diketomarcfortine B;   18a-Ethyl-24-methoxy-14,17-diketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14,17-diketomarcfortine B;   24,25-dihydro-14,17-diketomarcfortine C;   1- (p-bromobenzenesulfonyl) -14,17-diketomarcfortine C;   1-propionyl-14,17-diketomarkfortin C;   1-propyl-14,17-diketomarkfortin C;   1-benzyl-14,17-diketomarcfortine C;   18a-propyl-14,17-diketomarcfortine C;   18a-benzyl-14,17-diketomarkfortin C:   18a-methoxyethoxymethyl-14,17-diketomarcfortine C;   18-allyl-14,17-diketomarcfortine C;   18a-propargyl-14,17-diketomarkfortin C;   1,18a-bis-propyl-14,17-diketomarkfortin C;   1,18a-bis-benzyl-14,17-diketomarkfortin C;   14,17-Diketomarkfortin C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14, 17-diketomarkfortin A;   1-palmitoyl-14,17-diketomarkfortin A;   1- (4-morpholinocarbonyl) -14,17-diketomarcfortine A;   1-palmitoyl-14,17-diketomarkfortin D;   1- (4-morpholinocarbonyl) -14,17-diketomarkfortin D;   14,17-Diketomarkfortin D;   1-acetoxymethyl-14,17-diketomarcfortine D;   1-diethoxyphosphoryl-14,17-diketomarcfortine D;   1-dimethylsulfamoyl-14,17-diketomarkfortin D;   1-cyclopropylcarbonyl-14,17-diketomarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14,17-diketomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-14,17-diketomarcfortine D ;   1-succinoyl-14,17-diketomarkfortin D;   1- (4-morpholinosulphenyl) -14,17-diketomarkfortin D;   1- (2,4-dinitrobenzenesulfenyl) -14,17-diketomarkholch D;   24-propoxy-24,25-dihydro-14,17-diketomarkfortin D;   1- (p-toluenesulfonyl) -14,17-diketomarcfortine D;   1-acetyl-14,17-diketomarcfortine D;   1-methyl-14,17-diketomarcfortine D;   1-benzyl-14,17-diketomarkfortin D;   1-dimethylcarbamoyl-14,17-diketomarkfortin D;   1-methoxycarbonyl-14,17-diketomarcfortine D;   15,16-dehydro-14,17-diketomarcfortine A;   1-acetoxymethyl-15,16-dehydro-14,17-diketomarcfortine A;   1-diethoxyphosphoryl-15,16-dehydro-14,17-diketoxymark Hortin A;   1-Dimethylsulfamoyl-15,16-dehydro-14,17-diketomarko Rutin A;   1-cyclopropylcarbonyl-15,16-dehydro-14,17-diketomark Hortin A;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-14,17-dike Tomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-14,17-dike Tomarkfortin A;   1-succinoyl-15,16-dehydro-14,17-diketomarcfortine A;   1- (4-morpholinosulfenyl) -15,16-dehydro-14,17-diketomas Lukhortin A;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-14,17 -Diketmarkfortin A;   24-propoxy-24,25-dihydro-15,16-dehydro-14,17-diketo Marcfortine A;   1- (p-toluenesulfonyl) -15,16-dehydro-14,17-diketomark Hortin A;   1-acetyl-15,16-dehydro-14,17-diketomarcfortine A;   1-methyl-15,16-dehydro-14,17-diketomarcfortine A;   1-benzyl-15,16-dehydro-14,17-diketomarcfortine A;   1-Dimethylcarbamoyl-15,16-dehydro-14,17-diketomarkol Chin A;   1-methoxycarbonyl-15,16-dehydro-14,17-diketomarkholch A;   15,16-dehydro-14,17-diketomarkfortin B;   24,25-dihydro-15,16-dehydro-14,17-diketomarcfortine B ;   24-Methoxy-24,25-dihydro-15,16-dehydro-14,17-diketomers Lukhortin B;   1- (p-toluenesulfonyl) -15,16-dehydro-14,17-diketomark Hortin B;   1-ethyl-15,16-dehydro-14,17-diketomarcfortine B;   1-benzyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-Ethyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-benzyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-Methoxyethoxymethyl-15,16-dehydro-14,17-diketomal Kuhortin B;   18a-allyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-propargyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-15,16-dehydro-14 , 17-Diketomarkfortin B;   1,18a-bis-ethyl-15,16-dehydro-14,17-diketomarkholch B   1,18a-bis-benzyl-15,16-dehydro-14,17-diketomarkol Chin B;   18a-Ethyl-24-methoxy-15,16-dehydro-14,17-diketomark Hortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-15,16-dehydro-14,17-diketomas Lukhortin B;   24,25-dihydro-15,16-dehydro-14,17-diketomarcfortine C ;   1- (p-bromobenzenesulfonyl) -15,16-dehydro-14,17-diketo Marcfortine C;   1-propionyl-15,16-dehydro-14,17-diketomarcfortine C;   1-propyl-15,16-dehydro-14,17-diketomarcfortine C;   1-benzyl-15,16-dehydro-14,17-diketomarkfortin C;   18a-propyl-15,16-dehydro-14,17-diketomarcfortine C;   18a-benzyl-15,16-dehydro-14,17-diketomarcfortine C;   18a-Methoxyethoxymethyl-15,16-dehydro-14,17-diketomal Kuhortin C;   18-allyl-15,16-dehydro-14,17-diketomarcfortine C;   18a-propargyl-15,16-dehydro-14,17-diketomarcfortine C;   1,18a-bis-propyl-15,16-dehydro-14,17-diketomarkol Chin C;   1,18a-bis-benzyl-15,16-dehydro-14,17-diketomarkol Chin C;   15,16-dehydro-14,17-diketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-15, 16-dehydro-14,17-diketomarkfortin A;   1-palmitoyl-15,16-dehydro-14,17-diketomarcfortine A;   1- (4-morpholinocarbonyl) -15,16-dehydro-14,17-diketomal Kuhortin A;   1-palmitoyl-15,16-dehydro-14,17-diketomarcfortine D;   1- (4-morpholinocarbonyl) -15,16-dehydro-14,17-diketomal Kuhortin D;   15,16-dehydro-14,17-diketomarkfortin D;   1-acetoxymethyl-15,16-dehydro-14,17-diketomarcfortine D;   1-diethoxyphosphoryl-15,16-dehydro-14,17-diketomarkol Chin D;   1-Dimethylsulfamoyl-15,16-dehydro-14,17-diketomarko Rutin D;   1-cyclopropylcarbonyl-15,16-dehydro-14,17-diketomark Hortin D;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-14,17-dike Tomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-14,17-dike Tomarkfortin D;   1-succinoyl-15,16-dehydro-14,17-diketomarcfortine D;   1- (4-morpholinosulfenyl) -15,16-dehydro-14,17-diketomas Lukhortin D;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-14,17 -Diketmarkfortin D;   24-propoxy-24,25-dihydro-15,16-dehydro-14,17-diketo Marcfortine D;   1- (p-toluenesulfonyl) -15,16-dehydro-14,17-diketomark Hortin D;   1-acetyl-15,16-dehydro-14,17-diketomarcfortine D;   1-methyl-15,16-dehydro-14,17-diketomarcfortine D;   1-benzyl-15,16-dehydro-14,17-diketomarcfortine D;   1-Dimethylcarbamoyl-15,16-dehydro-14,17-diketomarkol Chin D;   1-methoxycarbonyl-15,16-dehydro-14,17-diketomarkholch D;   14α-hydroxy-14β-methyl-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-14β-methyl-17-ketomarcho Rutin A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-17-ketoxy Marcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-17-ketomer Lukhortin A;   1-cyclopropylcarbonyl-14α-hydroxy-14β-methyl-17-keto Marcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 7-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 17-ketomarkhortin A;   1-succinoyl-14α-hydroxy-14β-methyl-17-ketomarkholch A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-17- Ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Chill-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 7-ketomarkhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-17-keto Marcfortine A;   1-Acetyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A ;   1-methyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A ;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin A;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-17-ketomark Hortin A;   14α-hydroxy-14β-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-17-ketomarkol Chin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methyl-17 -Ketmarkhortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-17-keto Marcfortine B;   1-ethyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B ;   18a-Ethyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B;   18a-benzyl-14α-hydroxy-14β-methyl-17-ketomarkholch B   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-17-ke Tomarkfortin B;   18a-allyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B;   18a-Propargyl-14α-hydroxy-14β-methyl-17-ketomarkho Rutin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methyl-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-methyl-17-ketomark Hortin B;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methyl-17-keto Marcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methyl-17- Ketomarkhortin B;   24,25-Dihydro-14α-hydroxy-14β-methyl-17-ketomarkol Chin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-14β-methyl-1 7-ketomarkhortin C;   1-propionyl-14α-hydroxy-14β-methyl-17-ketomarkholch C   1-Propyl-14α-hydroxy-14β-methyl-17-ketomarcfortine C ;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine C ;   18a-Propyl-14α-hydroxy-14β-methyl-17-ketomarkholch C   18a-benzyl-14α-hydroxy-14β-methyl-17-ketomarkholch C   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-17-ke Tomarkfortin C;   18-allyl-14α-hydroxy-14β-methyl-17-ketomarcfortine C ;   18a-Propargyl-14α-hydroxy-14β-methyl-17-ketomarkho Rutin C;   1,18a-Bis-propyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin C;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin C;   14α-hydroxy-14β-methyl-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-14β-methyl-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-17-ketomarcholch A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-17- Ketomarkhortin A;   1-palmitoyl-14α-hydroxy-14β-methyl-17-ketomarcholch D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-17-ke Tomarkfortin D;   14α-hydroxy-14β-methyl-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methyl-17-ketomarcho Rutin D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-17-ketomer Lukhortin D;   1-cyclopropylcarbonyl-14α-hydroxy-14β-methyl-17-keto Marcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 7-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 17-ketomarkhortin D;   1-succinoyl-14α-hydroxy-14β-methyl-17-ketomarkholch D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-17- Ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Chill-17-ketomarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 7-ketomarkhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-17-keto Marcfortine D;   1-Acetyl-14α-hydroxy-14β-methyl-17-ketomarcfortine D ;   1-methyl-14α-hydroxy-14β-methyl-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine D ;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin D;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-17-ketomark Hortin D;   14-ketomarkhortin A;   1-acetoxymethyl-14-ketomarcfortine A;   1-diethoxyphosphoryl-14-ketomarcfortine A;   1-dimethylsulfamoyl-14-ketomarkfortin A;   1-cyclopropylcarbonyl-14-ketomarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14-ketomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-14-ketomarcfortine A;   1-succinoyl-14-ketomarkfortin A;   1- (4-morpholinosulphenyl) -14-ketomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14-ketomarcfortine A;   24-propoxy-24,25-dihydro-14-ketomarcfortine A;   1- (p-toluenesulfonyl) -14-ketomarcfortine A;   1-acetyl-14-ketomarcfortine A;   1-methyl-14-ketomarcfortine A;   1-benzyl-14-ketomarcfortine A;   1-dimethylcarbamoyl-14-ketomarcfortine A;   1-methoxycarbonyl-14-ketomarcfortine A;   14-ketomarkhortin B;   24,25-dihydro-14-ketomarcfortine B;   24-methoxy-24,25-dihydro-14-ketomarcfortine B;   1- (p-toluenesulfonyl) -14-ketomarcfortine B;   1-ethyl-14-ketomarcfortine B;   1-benzyl-14-ketomarcfortine B;   18a-ethyl-14-ketomarcfortine B;   18a-benzyl-14-ketomarcfortine B;   18a-methoxyethoxymethyl-14-ketomarcfortine B;   18a-allyl-14-ketomarcfortine B;   18a-propargyl-14-ketomarkhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14-ketomarcfortine B;   1,18a-bis-ethyl-14-ketomarcfortine B;   1,18a-bis-benzyl-14-ketomarcfortine B;   18a-Ethyl-24-methoxy-14-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-ethyl-24,25-dihydro-14-ketomarcfortine B;   24,25-dihydro-14-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -14-ketomarcfortine C;   1-propionyl-14-ketomarcfortine C;   1-propyl-14-ketomarcfortine C;   1-benzyl-14-ketomarcfortine C;   18a-propyl-14-ketomarcfortine C;   18a-benzyl-14-ketomarcfortine C;   18a-methoxyethoxymethyl-14-ketomarcfortine C;   18-allyl-14-ketomarcfortine C;   18a-propargyl-14-ketomarcfortine C;   1,18a-bis-propyl-14-ketomarcfortine C;   1,18a-bis-benzyl-14-ketomarcfortine C;   14-ketomarkhortin C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14- Ketomarkhortin A;   1-palmitoyl-14-ketomarkfortin A;   1- (4-morpholinocarbonyl) -14-ketomarcfortine A;   1-palmitoyl-14-ketomarkfortin D;   1- (4-morpholinocarbonyl) -14-ketomarkfortin D;   14-ketomarkhortin D;   1-acetoxymethyl-14-ketomarcfortine D;   1-diethoxyphosphoryl-14-ketomarcfortine D;   1-dimethylsulfamoyl-14-ketomarkfortin D;   1-Cyclopropylcarbonyl-14-ketomarcfortine D:   2-bicyclo [2. 2. 1] heptanoyl-14-ketomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-14-ketomarcfortine D;   1-succinoyl-14-ketomarkfortin D;   1- (4-morpholinosulfenyl) -14-ketomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14-ketomarcfortine D;   24-propoxy-24,25-dihydro-14-ketomarcfortine D;   1- (p-toluenesulfonyl) -14-ketomarcfortine D;   1-acetyl-14-ketomarcfortine D;   1-methyl-14-ketomarcfortine D;   1-benzyl-14-ketomarcfortine D;   1-dimethylcarbamoyl-14-ketomarcfortine D;   1-methoxycarbonyl-14-ketomarcfortine D;   16-dithio-17-ketomarcfortine A;   1-acetoxymethyl-16-dithio-17-ketomarcfortine A;   1-diethoxyphosphoryl-16-dithio-17-ketoxymarkfortin A;   1-dimethylsulfamoyl-16-dithio-17-ketomarcfortine A;   1-cyclopropylcarbonyl-16-dithio-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-16-dithio-17-ketomarkholch A;   1- (1-piperidinyl) thiocarbonyl-16-dithio-17-ketomarkholch The A;   1-succinoyl-16-dithio-17-ketomarcfortine A;   1- (4-morpholinosulphenyl) -16-dithio-17-ketomarcfortine A ;   1- (2,4-dinitrobenzenesulfenyl) -16-dithio-17-ketomark Hortin A;   24-propoxy-24,25-dihydro-16-dithio-17-ketomarcfortine A;   1- (p-toluenesulfonyl) -16-dithio-17-ketomarcfortine A;   1-acetyl-16-dithio-17-ketomarcfortine A;   1-methyl-16-dithio-17-ketomarcfortine A;   1-benzyl-16-dithio-17-ketomarcfortine A;   1-dimethylcarbamoyl-16-dithio-17-ketomarcfortine A;   1-methoxycarbonyl-16-dithio-17-ketomarcfortine A;   16-dithio-17-ketomarcfortine B;   24,25-dihydro-16-dithio-17-ketomarcfortine B;   24-Methoxy-24,25-dihydro-16-dithio-17-ketomarcfortine B ;   1- (p-toluenesulfonyl) -16-dithio-17-ketomarcfortine B;   1-ethyl-16-dithio-17-ketomarcfortine B;   1-benzyl-16-dithio-17-ketomarcfortine B;   18a-ethyl-16-dithio-17-ketomarcfortine B;   18a-benzyl-16-dithio-17-ketomarcfortine B;   18a-methoxyethoxymethyl-16-dithio-17-ketomarcfortine B;   18a-allyl-16-dithio-17-ketomarcfortine B;   18a-propargyl-16-dithio-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-16-dithio-17-ketomer Lukhortin B;   1,18a-bis-ethyl-16-dithio-17-ketomarcfortine B;   1,18a-bis-benzyl-16-dithio-17-ketomarcfortine B;   18a-ethyl-24-methoxy-16-dithio-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-16-dithio-17-ketomarcfortine B ;   24,25-dihydro-16-dithio-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -16-dithio-17-ketomarcfortine C;   1-propionyl-16-dithio-17-ketomarcfortine C;   1-propyl-16-dithio-17-ketomarcfortine C;   1-benzyl-16-dithio-17-ketomarcfortine C;   18a-propyl-16-dithio-17-ketomarcfortine C;   18a-benzyl-16-dithio-17-ketomarcfortine C;   18a-methoxyethoxymethyl-16-dithio-17-ketomarcfortine C;   18-allyl-16-dithio-17-ketomarcfortine C;   18a-propargyl-16-dithio-17-ketomarcfortine C;   1,18a-bis-propyl-16-dithio-17-ketomarcfortine C;   1,18a-bis-benzyl-16-dithio-17-ketomarcfortine C;   16-dithio-17-ketomarcfortine C;   1- (4-Carboethoxy-1,3-thiazolidinin-1,3-yl) carbonyl-1 6-dithio-17-ketomarcfortine A;   1-palmitoyl-16-dithio-17-ketomarcfortine A;   1- (4-morpholinocarbonyl) -16-dithio-17-ketomarcfortine A;   1-palmitoyl-16-dithio-17-ketomarcfortine D;   1- (4-morpholinocarbonyl) -16-dithio-17-ketomarcfortine D;   16-dithio-17-ketodroxymarcfortine D;   1-acetoxymethyl-16-dithio-17-ketomarcfortine D;   1-diethoxyphosphoryl-16-dithio-17-ketomarcfortine D;   1-dimethylsulfamoyl-16-dithio-17-ketomarcfortine D;   1-cyclopropylcarbonyl-16-dithio-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-16-dithio-17-ketomarkholch D;   1- (1-piperidinyl) thiocarbonyl-16-dithio-17-ketomarkholch D;   1-succinoyl-16-dithio-17-ketomarcfortine D;   1- (4-morpholinosulphenyl) -16-dithio-17-ketomarcfortine D ;   1- (2,4-dinitrobenzenesulfenyl) -16-dithio-17-ketomark Hortin D;   24-propoxy-24,25-dihydro-16-dithio-17-ketomarcfortine D;   1- (p-toluenesulfonyl) -16-dithio-17-ketomarcfortine D;   1-acetyl-16-dithio-17-ketomarcfortine D;   1-methyl-16-dithio-17-ketomarcfortine D;   1-benzyl-16-dithio-17-ketomarcfortine D;   1-dimethylcarbamoyl-16-dithio-17-ketomarcfortine D; or   1-Methoxycarbonyl-16-dithio-17-ketomarcfortine D.   16-thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-acetoxymethyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin A;   1-diethoxyphosphoryl-16-thiophenyl-15,16-dehydro-17-keto Ximarkfortin A;   1-dimethylsulfamoyl-16-thiophenyl-15,16-dehydro-17-ke Tomarkfortin A;   1-cyclopropylcarbonyl-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin A;   2-bicyclo [2. 2. 1] Heptanoyl-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-16-thiophenyl-15,16-dehi Doro-17-ketomarkhortin A;   1-succinoyl-16-thiophenyl-15,16-dehydro-17-ketomarkouf Rutin A;   1- (4-morpholinosulphenyl) -16-thiophenyl-15,16-dehydro- 17-ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -16-thiophenyl-15,16- Dehydro-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin A;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 -Ketmarkhortin A;   1-acetyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch A;   1-methyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch A;   1-dimethylcarbamoyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine A;   1-methoxycarbonyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin A;   16-thiophenyl-15,16-dehydro-17-ketomarcfortine B;   24,25-dihydro-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin B;   24-Methoxy-24,25-dihydro-16-thiophenyl-15,16-dehydro- 17-ketomarkhortin B;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 - Ketomarkhortin B;   1-Ethyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine B;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch B   18a-Ethyl-16-thiophenyl-15,16-dehydro-17-ketomarkol Chin B;   18a-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin B;   18a-Methoxyethoxymethyl-16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin B;   18a-allyl-16-thiophenyl-15,16-dehydro-17-ketomarkol Chin B;   18a-Propargyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-16-thiophenyl-15, 16-dehydro-17-ketomarcfortine B;   1,18a-bis-ethyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin B;   1,18a-bis-benzyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine B;   18a-Ethyl-24-methoxy-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-16-thiophenyl-15,16-dehydro- 17-ketomarkhortin B;   24,25-dihydro-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin C;   1- (p-bromobenzenesulfonyl) -16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin C;   1-propionyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin C;   1-Propyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   18a-Propyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin C;   18a-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin C;   18a-Methoxyethoxymethyl-16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin C;   18-allyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   18a-Propargyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin C;   1,18a-bis-propyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine C;   1,18a-bis-benzyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine C;   16-thiophenyl-15,16-dehydro-17-ketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-16- Thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-palmitoyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinocarbonyl) -16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin A;   1-palmitoyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinocarbonyl) -16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin D;   16-thiophenyl-15,16-dehydro-17-ketodroxymarcfortine D ;   1-acetoxymethyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin D;   1-diethoxyphosphoryl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine D;   1-dimethylsulfamoyl-16-thiophenyl-15,16-dehydro-17-ke Tomarkfortin D;   1-cyclopropylcarbonyl-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin D;   2-bicyclo [2. 2. 1] Heptanoyl-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-16-thiophenyl-15,16-dehi Doro-17-ketomarkhortin D;   1-succinoyl-16-thiophenyl-15,16-dehydro-17-ketomarkouf Rutin D;   1- (4-morpholinosulphenyl) -16-thiophenyl-15,16-dehydro- 17-ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -16-thiophenyl-15,16- Dehydro-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin D;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 -Ketmarkhortin D;   1-acetyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch D;   1-methyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch D;   1-dimethylcarbamoyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine D; or   1-methoxycarbonyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin D.   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkhortin A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl- 17-Ketoxymarkfortin A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Le-17-ketomarkhortin A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methyl-17-ketomarcfortine A;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarkfortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methyl-17-ketomarcfortine A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin A;   1-acetyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin A;   1-methyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomal Kuhortin A;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin A;   1-methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methyl-1 7-ketomarkhortin A;   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methyl-17- Ketomarkhortin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarcfortine B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin B;   1-Ethyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomal Kuhortin B;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin B;   18a-Ethyl-14α-hydroxy-14β-methyl-15α-methyl-17-keto Marcfortine B;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarcfortine B;   18a-allyl-14α-hydroxy-14β-methyl-15α-methyl-17-keto Marcfortine B;   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methyl-15α-methyl-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-methyl-15α-methyl-1 7-ketomarkhortin B;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methyl-17- Ketomarkhortin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine C;   1-propionyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin C;   1-Propyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomer Lukhortin C;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin C;   18a-Propyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin C;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarcfortine C;   18-allyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin C;   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkfortin C;   1,18a-bis-propyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin C;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin C;   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarkfortin A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarkfortin D;   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkhortin D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Le-17-ketomarkhortin D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methyl-17-ketomarcfortine D;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methyl-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin D;   1-acetyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin D;   1-methyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomal Kuhortin D;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin D;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin D;   1-methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methyl-1 7-ketomarkhortin D;   14α-hydroxy-15α-methyl-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin A;   1-diethoxyphosphoryl-14α-hydroxy-15α-methyl-17-ketoxy Marcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methyl-17-ketomer Lukhortin A;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methyl-17-keto Marcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methyl-1 7-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methyl- 17-ketomarkhortin A;   1-succinoyl-14α-hydroxy-15α-methyl-17-ketomarcholch A;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methyl-17- Ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Chi Le-17-ketomarkhortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methyl-1 7-ketomarkhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methyl-17-keto Marcfortine A;   1-Acetyl-14α-hydroxy-15α-methyl-17-ketomarcfortine A ;   1-methyl-14α-hydroxy-15α-methyl-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine A ;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin A;   1-methoxycarbonyl-14α-hydroxy-15α-methyl-17-ketomark Hortin A;   14α-hydroxy-15α-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-15α-methyl-17-ketomarkol Chin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-15α-methyl-17 -Ketmarkhortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methyl-17-keto Marcfortine B;   1-ethyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B ;   18a-Ethyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B;   18a-benzyl-14α-hydroxy-15α-methyl-17-ketomarkholch B   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methyl-17-ke Tomarkfortin B;   18a-allyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B;   18a-Propargyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-15 α-methyl-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-15α-methyl-17-ketomark Hortin B;   1,18a-bis-benzyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin B;   18a-Ethyl-24-methoxy-14α-hydroxy-15α-methyl-17-keto Marcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-15α-methyl-17- Ketomarkhortin B;   24,25-Dihydro-14α-hydroxy-15α-methyl-17-ketomarkol Chin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-15α-methyl-1 7-ketomarkhortin C;   1-propionyl-14α-hydroxy-15α-methyl-17-ketomarcholch C   1-Propyl-14α-hydroxy-15α-methyl-17-ketomarcfortine C ;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine C ;   18a-Propyl-14α-hydroxy-15α-methyl-17-ketomarkholch C   18a-benzyl-14α-hydroxy-15α-methyl-17-ketomarkholch C   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methyl-17-ke Tomarkfortin C;   18-allyl-14α-hydroxy-15α-methyl-17-ketomarcfortine C ;   18a-Propargyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin C;   1,18a-Bis-propyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin C;   1,18a-bis-benzyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin C;   14α-hydroxy-15α-methyl-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-15α-methyl-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-15α-methyl-17-ketomarkholch A;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methyl-17-ke Tomarkfortin A;   1-palmitoyl-14α-hydroxy-15α-methyl-17-ketomarkholch D;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methyl-17-ke Tomarkfortin D;   14α-hydroxy-15α-methyl-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin D;   1-diethoxyphosphoryl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin D;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methyl-17-ketomer Lukhortin D;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methyl-17-keto Marcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methyl-1 7-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methyl- 17-ketomarkhortin D;   1-succinoyl-14α-hydroxy-15α-methyl-17-ketomarcholch D;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methyl-17- Ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Chill-17-ketomarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methyl-1 7-ketomarkhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methyl-17-keto Marcfortine D;   1-acetyl-14α-hydroxy-15α-methyl-17-ketomarcfortine D ;   1-methyl-14α-hydroxy-15α-methyl-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine D ;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin D;   1-methoxycarbonyl-14α-hydroxy-15α-methyl-17-ketomark Hortin D;   15α-methyl-14,17-diketomarkfortin A;   1-acetoxymethyl-15α-methyl-14,17-diketomarkfortin A;   1-diethoxyphosphoryl-15α-methyl-14,17-diketoxymarkholch A;   1-Dimethylsulfamoyl-15α-methyl-14,17-diketomarcfortine A;   1-Cyclopropylcarbonyl-15α-methyl-14,17-diketomarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-15α-methyl-14,17-diketomal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-15α-methyl-14,17-diketomer Lukhortin A;   1-succinoyl-15α-methyl-14,17-diketomarkfortin A;   1- (4-morpholinosulphenyl) -15α-methyl-14,17-diketomark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -15α-methyl-14,17-dike Tomarkfortin A;   24-propoxy-24,25-dihydro-15α-methyl-14,17-diketomal Kuhortin A;   1- (p-toluenesulfonyl) -15α-methyl-14,17-diketomarkol Chin A;   1-acetyl-15α-methyl-14,17-diketomarcfortine A;   1-methyl-15α-methyl-14,17-diketomarcfortine A;   1-benzyl-15α-methyl-14,17-diketomarcfortine A;   1-Dimethylcarbamoyl-15α-methyl-14,17-diketomarcfortine A ;   1-methoxycarbonyl-15α-methyl-14,17-diketomarcfortine A;   15α-methyl-14,17-diketomarcfortine B;   24,25-dihydro-15α-methyl-14,17-diketomarcfortine B;   24-Methoxy-24,25-dihydro-15α-methyl-14,17-diketomark Hortin B;   1- (p-toluenesulfonyl) -15α-methyl-14,17-diketomarkol Chin B;   1-ethyl-15α-methyl-14,17-diketomarcfortine B;   1-benzyl-15α-methyl-14,17-diketomarcfortine B;   18a-Ethyl-15α-methyl-14,17-diketomarcfortine B;   18a-benzyl-15α-methyl-14,17-diketomarcfortine B;   18a-Methoxyethoxymethyl-15α-methyl-14,17-diketomarkol Chin B;   18a-allyl-15α-methyl-14,17-diketomarcfortine B;   18a-propargyl-15α-methyl-14,17-diketomarkfortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-15α-methyl-14,17 -Diketmarkfortin B;   1,18a-bis-ethyl-15α-methyl-14,17-diketomarcfortine B;   1,18a-bis-benzyl-15α-methyl-14,17-diketomarcfortine B ;   18a-Ethyl-24-methoxy-15α-methyl-14,17-diketomarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-15α-methyl-14,17-diketomark Hortin B;   24,25-dihydro-15α-methyl-14,17-diketomarcfortine C;   1- (p-bromobenzenesulfonyl) -15α-methyl-14,17-diketomal Kuhortin C;   1-propionyl-15α-methyl-14,17-diketomarcfortine C;   1-propyl-15α-methyl-14,17-diketomarkfortin C;   1-benzyl-15α-methyl-14,17-diketomarcfortine C;   18a-Propyl-15α-methyl-14,17-diketomarcfortine C;   18a-benzyl-15α-methyl-14,17-diketomarcfortine C;   18a-Methoxyethoxymethyl-15α-methyl-14,17-diketomarkol Chin C;   18-allyl-15α-methyl-14,17-diketomarcfortine C;   18a-propargyl-15α-methyl-14,17-diketomarcfortine C;   1,18a-bis-propyl-15α-methyl-14,17-diketomarcfortine C ;   1,18a-bis-benzyl-15α-methyl-14,17-diketomarcfortine C ;   15α-methyl-14,17-diketomarkfortin C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-15α -Methyl-14,17-diketomarcfortine A;   1-palmitoyl-15α-methyl-14,17-diketomarkfortin A;   1- (4-morpholinocarbonyl) -15α-methyl-14,17-diketomarko Rutin A;   1-palmitoyl-15α-methyl-14,17-diketomarkfortin D;   1- (4-morpholinocarbonyl) -15α-methyl-14,17-diketomarko Rutin D;   15α-methyl-14,17-diketomarcfortine D;   1-acetoxymethyl-15α-methyl-14,17-diketomarkfortin D;   1-diethoxyphosphoryl-15α-methyl-14,17-diketomarcfortine D ;   1-Dimethylsulfamoyl-15α-methyl-14,17-diketomarcfortine D;   1-Cyclopropylcarbonyl-15α-methyl-14,17-diketomarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-15α-methyl-14,17-diketomal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-15α-methyl-14,17-diketomer Lukhortin D;   1-succinoyl-15α-methyl-14,17-diketomarkfortin D;   1- (4-morpholinosulphenyl) -15α-methyl-14,17-diketomark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -15α-methyl-14,17-dike Tomarkfortin D;   24-propoxy-24,25-dihydro-15α-methyl-14,17-diketomal Kuhortin D;   1- (p-toluenesulfonyl) -15α-methyl-14,17-diketomarkol Chin D;   1-acetyl-15α-methyl-14,17-diketomarcfortine D;   1-methyl-15α-methyl-14,17-diketomarcfortine D;   1-benzyl-15α-methyl-14,17-diketomarcfortine D;   1-Dimethylcarbamoyl-15α-methyl-14,17-diketomarkfortin D ;   1-methoxycarbonyl-15α-methyl-14,17-diketomarcfortine D;   14,15-dehydro-16,17-diketomarcfortine A;   1-acetoxymethyl-14,15-dehydro-16,17-diketomarcfortine A;   1-diethoxyphosphoryl-14,15-dehydro-16,17-diketoxymark Hortin A;   1-Dimethylsulfamoyl-14,15-dehydro-16,17-diketomarko Rutin A;   1-cyclopropylcarbonyl-14,15-dehydro-16,17-diketomark Hortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14,15-dehydro-16,17-dike Tomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-14,15-dehydro-16,17-dike Tomarkfortin A;   1-succinoyl-14,15-dehydro-16,17-diketomarcfortine A;   1- (4-morpholinosulfenyl) -14,15-dehydro-16,17-diketomas Lukhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14,15-dehydro-16,17 -Diketmarkfortin A;   24-propoxy-24,25-dihydro-14,15-dehydro-16,17-diketo Marcfortine A;   1- (p-toluenesulfonyl) -14,15-dehydro-16,17-diketomark Hortin A;   1-acetyl-14,15-dehydro-16,17-diketomarcfortine A;   1-methyl-14,15-dehydro-16,17-diketomarcfortine A;   1-benzyl-14,15-dehydro-diketomarcfortine A;   1-dimethylcarbamoyl-14,15-dehydro-16,17-diketomarkol Chin A;   1-Methoxycarbonyl-14,15-dehydro-16,17-diketomarkholch A;   14,15-dehydro-16,17-diketomarcfortine B;   24,25-dihydro-14,15-dehydro-16,17-diketomarcfortine B ;   24-methoxy-24,25-dihydro-14,15-dehydro-16,17-diketomers Lukhortin B;   1- (p-toluenesulfonyl) -14,15-dehydro-16,17-diketomark Hortin B;   1-ethyl-14,15-dehydro-16,17-diketomarcfortine B;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Ethyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-benzyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Methoxyethoxymethyl-14,15-dehydro-16,17-diketomal Kuhortin B;   18a-allyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Propargyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14,15-dehydro-16 , 17-diketomarkfortin B;   1,18a-bis-ethyl-14,15-dehydro-16,17-diketomarkholch B   1,18a-bis-benzyl-14,15-dehydro-16,17-diketomarkol Chin B;   18a-Ethyl-24-methoxy-14,15-dehydro-16,17-diketomark Hortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14,15-dehydro-16,17-diketomas Lukhortin B;   24,25-dihydro-14,15-dehydro-16,17-diketomarcfortine C ;   1- (p-bromobenzenesulfonyl) -14,15-dehydro-16,17-diketo Marcfortine C;   1-propionyl-14,15-dehydro-16,17-diketomarcfortine C;   1-propyl-14,15-dehydro-16,17-diketomarcfortine C;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-propyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-benzyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-Methoxyethoxymethyl-14,15-dehydro-16,17-diketomal Kuhortin C;   18-allyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-Propargyl-14,15-dehydro-16,17-diketomarcfortine C;   1,18a-bis-propyl-14,15-dehydro-16,17-diketomarkol Chin C;   1,18a-bis-benzyl-14,15-dehydro-16,17-diketomarkol Chin C;   14,15-dehydro-16,17-diketomarkfortin C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14, 15-dehydro-16,17-diketomarcfortine A;   1-palmitoyl-14,15-dehydro-16,17-diketomarcfortine A;   1- (4-morpholinocarbonyl) -14,15-dehydro-16,17-diketomal Kuhortin A;   1-palmitoyl-14,15-dehydro-16,17-diketomarcfortine D;   1- (4-morpholinocarbonyl) -14,15-dehydro-16,17-diketomal Kuhortin D;   14,15-dehydro-16,17-diketomarkfortin D;   1-acetoxymethyl-14,15-dehydro-16,17-diketomarcfortine D;   1-diethoxyphosphoryl-14,15-dehydro-16,17-diketomarkol Chin D;   1-Dimethylsulfamoyl-14,15-dehydro-16,17-diketomarko Rutin D;   1-cyclopropylcarbonyl-14,15-dehydro-16,17-diketomark Hortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14,15-dehydro-16,17-dike Tomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-14,15-dehydro-16,17-dike Tomarkfortin D;   1-succinoyl-14,15-dehydro-16,17-diketomarcfortine D;   1- (4-morpholinosulfenyl) -14,15-dehydro-16,17-diketomas Lukhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14,15-dehydro-16,17 -Diketmarkfortin D;   24-propoxy-24,25-dihydro-14,15-dehydro-16,17-diketo Marcfortine D;   1- (p-toluenesulfonyl) -14,15-dehydro-16,17-diketomark Hortin D;   1-acetyl-14,15-dehydro-16,17-diketomarcfortine D;   1-methyl-14,15-dehydro-16,17-diketomarcfortine D;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine D;   1-dimethylcarbamoyl-14,15-dehydro-16,17-diketomarkol Chin D; and   1-Methoxycarbonyl-14,15-dehydro-16,17-diketomarkholch D.   A general method for producing heteroaromatic ring N-oxides was the academic preparatory method in 1971. (Organic Chemistry-Monograph Series (ORG Volume 19 of ANICCHEMISTRY-A Series of Monographs) "Heterocycle N-Oki Chemistry of the Heterocyclic N-Oxides Ritsuky (A. R. Katrizky) and Jay M. Lagowski (J. M. Lagowski) Can be found in Chapter II of. Typically, the N-oxide is a suitable solvent Formed by reaction with the percarboxylic acid therein. Most suitably, usually at room temperature Aromatic peracids in non-polar solvents are used because they can be reacted. Suitable aromatic Peracids include perbenzoic acid, chloroperbenzoic acid and perphthalic acid.                               Production of starting materials   N-18a substituted marcfortines B and C, and C24-C25 modified marc Hortin is described in US Pat. No. 4,923,8 (which is hereby incorporated by reference). It can be easily produced by the method described in No. 67.   Marcfortine A, B, and C were penniesed using standard fermentation and isolation techniques. As a bacterial metabolite of Penicillium roqueforti, It is isolated together with the well-known Roquefortine. Isolation and analysis of Marcfortine A And structural features are described in Polonsky et al., Journal of the Chemi Cal Society Chemical Communications (Journal of the Che mical Society Chemical Communications), 1980, p.601-602. It is described in detail. Isolation of Marcfortine B and C, and analytical and Structural features are described in Polonsky et al., Tetredron Letters (Tetr). ahedron Letters), 1981, Vol. 22, 1977-1980. Have been.   Alternatively, and more preferably, marcfortine A, C and D are The Up John Company, Kalamazoo, MI Upjohn Culture, Inc.  Stock No. UC77790) Penicillium spp.  sp. ) It can be isolated from UC7780. This strain was collected in Illinois Isolated from isolated soil samples, Yues, Peoria, IL, Illinois ・ Department of Agriculture Patent Culture Collection Deposited with the deposit number NRRL18887. Further characterize the fungus For the I John Pitt (I. John Pitt's "The Genus  Penicillium ”, Academic Press, London (Academic Press, Londo Classification experiments were performed according to the methods and materials described by n). Spores and The surface of the hyphae is from Dietz, A. ) And Matthews, The ws, J. ), Applied Microbiology, Volume 18; 6 Scan with a scanning electron microscope according to the method of pages 94-696 (1969). It was The intact conidiophore was visualized by light microscopy after slide culture was prepared. Turn into [A.H.S.Onions (A. H. S. Onions) et al., “Smith Industry Smith's Introduction to Industrial Mycology ”, John Wa John Wiley and Sons, New York k) 301-302 (1979)]: Glass Petri dish containing glass beads, microscopic Sterilize microscope slides and coverslips. Potato dext Place a small block of loin agar on the glass slide and inoculate the four corners with the bacterial culture. . Cover the inoculated agar block with a cover glass and add sterile water to add water. Keep the minute. The chamber is incubated at 24 ° C for 6 days. The power Remove the bargrass and stain it with a drop of lactophenol cotton blue Prepare a glass slide by pouring the liquid.   The characteristics of Penicillium sp. UC7780 (NRRL 18887) are as follows:   Morphology-Multi-axis bifurcated penicillus (two bifurcation points between conidia and peduncle) These Branch (metre) supports the structurally responsible phialides or conidia . Conidia peduncle (about 35 μm) are 2-5 (10-14 μm) metre circles It ended in. Phialides are 2-5 (7 μm) ring organisms (Ancient Greek It was an ampoule shape (like a wine jar). Conidia are typically long It was smooth and oblong (2 μm) like a cylinder. The patterned wall was smooth.   Each of the cultures had a diameter of 6 cm, and each of the cultures was malt extract agar medium (MEA). And 25% glycerin nitrate agar (G25N), three Czapek yeast agars Inoculation was performed on a Heaven Medium (CYA) Petri dish. The inoculum was a semi-solid suspension (0. 05% Tsui 0 including 80. 2% agar 0. 5 ml). Loop conidia for inoculation Added to test tube and mixed. Loop-shaped suspension with a pattern of 3 sites per plate Was inoculated at. A 6 cm dish was punctured with a needle. Incubation mode Is: one CYA dish + MEA and G25N dish at 24 ° C, one at 37 ° C The CYA dish was a 6 cm CYA dish at 5 ° C. Colony diameter, color after 7 days , And other characteristics are recorded and are listed in Table I. Potato dextro On agar agar (PDA, Difco), the bottom or back is deep Red colonies are formed.   No sexual generation was recognized. This result in culture (NRRL 18887) Fruit is a key in the Penicillium Search Table divided into subgenus . Within the Penicillium Lookup Table, species are located by Penicillus type only. The subgenus to be performed is determined. This species has a vivar, even if its penicillus is biaxially branched. -It has several features that distinguish it from the subgenus Ticillium. The seed is 7 days Consistently forms colonies over 10 mm in diameter on glycerol nitrate agar between To do. Its metre is longer than the phialide and appears to be in 2-5 ringed organisms Ah It Due to these characteristics, this penicillium species (NRRL 18887) It is located in the subgenus Furcatum.   The above description can be used for the production of marcfortine and its derivatives 1 is an example of a Penicillium sp. UC7780 (NRRL 18887) strain. But However, the present invention also includes mutants of the aforementioned microorganisms. For example, natural Mutants obtained by culturing, ionizing radiation such as UV irradiation, or Produced by mutagens, including chemical mutagens such as treatment with trosoguanidine Are also included within the scope of the present invention.   This description includes, for example, conjugation, transition and genes. Created by genetic techniques well known to those skilled in the art, such as engineering techniques It is intended and meant to include interspecific and intraspecific genetic recombinants as well. It   Penicillium sp. UC7780 (NRRL 18887) is a Penicillium spp. It can be grown under aerobic conditions similar to those commonly used in known culture techniques. It   Use any of the well-known nutrients for penicillium as media components. You can For example, anabolic carbon sources include glucose, glycerin, malto Sugar, dextrin, starch, lactose, sucrose, molasses, soybean oil, cotton Seed oil and the like, preferably glucose and glycerin, can be used, Soybean meal, peanut meal, cottonseed meal, fish meal , Corn steep liquor, peptone, rice, bran, meat extract, yeast, yeast Use extracts, sodium nitrate, ammonium nitrate, ammonium sulfate, etc. Can be. In addition, inorganic salts such as sodium chloride, phosphate, calcium carbonate, etc. Can also be added to the culture medium. If necessary, trace amounts of metal salts can be added. it can. Further, if necessary, a trace amount of heavy metal can be added.   Especially, in the culture of the Penicillium species (NRRL 18887) under aerobic conditions, Aerobic conditions such as solid culture, culture under aeration and agitation, and shaking culture. A culture method can be preferably used.   When culturing while supplying air and stirring, for example, silicone oil, vegetable oil , An antifoaming agent such as a surfactant can be appropriately used.   The pH of the medium is usually within the range of 3-9, preferably within or near the neutral range. The culturing temperature can be usually 20 ° C. to 30 ° C. C is especially preferred.   Culturing is usually performed at 20 hours until marcfortin A is substantially accumulated in the culture medium. For between ~ 240 hours, preferably 48-168 hours, and cultured Later, Marcfortine A was cultured by combining various methods appropriately. It can be isolated from ross and recovered. For example, ether, ethyl acetate or chloroform Extracted with an organic solvent such as; for example, highly polar such as acetone or alcohol Soluble in solvents; low polar solvents, eg petroleum ether or hexane, active Removal of impurities by adsorption chromatography with charcoal or silica gel; (US, Pharmacia Co., Ltd. , Ltd. Get from) Gel filtration through a "sephadex" column (possible); and so on Can be   Unexpectedly, the compounds of the present invention find that internal and ectoparasites, especially human parasites. Latents against helminths and arthropods that cause a great deal of parasitic disease on animals, plants and animals. It is a potential antiparasitic agent.   Parasitism can be caused by either endoparasites or ectoparasites . Endoparasites are found in tissues (such as the stomach, lungs, heart, intestines) or simply under the skin. It is a parasite that lives in either host body. Ectoparasites are on the outer surface of the host It is a parasite that inhabits, but still pumps nutrients from its host.   An endoparasitic disease, commonly referred to as helminthic disease, is a parasite infestation known as helminth Caused by the main infection. Helminth diseases include pigs, sheep, horses, cows, goats, dogs, An epidemic and significant global cause of infection of livestock animals such as cats and poultry Economic problems. Many of these infections are caused by various movements that are widespread throughout the world. Caused by a group of helminths described as nematodes that cause disease in species . These diseases are often severe, and the infected animal may die. In the above The most common genus of nematodes that infect the indicated animals is Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris ), Bunostomum (Bunostomum), Esophagostomum (Oesophagostomum), Chabertia, Trichuris, Strongilas ( Strongylus, Triconema, Dityocaulu s), Capillaria, Heterakis, Toxocara Toxocara), Ascaridia, Oxyuris, Ancillo Stoma (Ancylostoma), Uncinaria, Toxa squirrel (Toxa) scaris) and Parascaris. Many parasites Species-specific) (mostly transmitted only), and most of them are It has a good part. Thus, Haemoncus and Ostertagia are mainly Infects the stomach, whereas Nematogius and Coupelia mostly attack the intestine To do. While some parasites prefer to live in the heart, eyes, lungs, blood vessels, etc. The thing is a subcutaneous parasite. Helminth disease is frailty, weight loss, anemia, intestinal disorders, nutritional disorders. It can lead to harm and damage to other organs. If you leave these diseases untreated, The animal may die.   Such as ticks, mites, lice, sand flies, horn flies, blow flies, fleas, etc. Infection by ectoparasite arthropod insects is also a serious problem. Infection by these parasites It causes blood loss, skin spots, interferes with normal eating habits, and thus causes weight loss. It can happen. These infections can result in deadly encephalitis, anaplasmosis, swinepox and It can also be the transmission of serious illnesses such as other illnesses.   Infection with one parasite weakens the animal, which can cause sensations from a second parasite species. Infects animals with several parasites at the same time, making them more susceptible to staining Sometimes Thus, it has a broad spectrum of activity for the treatment of these diseases The compounds are particularly advantageous. Unexpectedly, the compounds of the present invention are It has a high activity on the body, and in addition, Dirofilari (Dirofilari) in dogs. a), Nematospiroides and Sifaci in rodents (Syphacia), Hypoderma sp. ) Gastrophilus in bite and migratory diptera insect larvae and horses (Gastrophilus) is also active.   The compounds of the present invention also act on endo- and ectoparasites that cause parasitic diseases in humans. Also useful. Examples of such endoparasites that infect humans include ancilost Ancylostoma, Necator, Ascaris, Stro Strongyloides, Trichinella, Capillary ( Capillaria, Trichuris, Enterobius, etc. Gastrointestinal parasites of. Other endoparasites that infect humans are blood or other organs. Found in the government. An example of such a parasite is the filamentous insect Wucheria. , Brugia, Onchocerca, etc., and intestinal helminth strikes Extraintestinal stages of Longylides and Trichinella Is. Ectoparasites that parasitize humans include ticks, fleas, mites, lice, etc. For livestock that contain arthropod insects and are infected by these parasites, It can also cause the spread of disease that can lead to death and even death. The compounds of the present invention are Mouth bites that are active against these endo- and ectoparasites and further bother humans It is also active against sex insects and other dipterous pests. Orally or parenterally In some cases, the compound of the present invention is Administered at a dose rate of 05-20 mg / kg animal body weight It   The compound of the present invention is a compound of Blatella sp. ) (Roaches), Cineola species ( Tineola sp. ) (Squid), Attagenus sp. ) (Katsuobushimushi) , Musca domestica (housefly) and Solenopsis ・ Responding to common household pests such as Invicta (Solenopsis Invicta) Even useful.   Further, the compound is aphid (Acyrthiosiphon sp. ) ), Grasshoppers and Mexican boll weevil, and Tribori Tribolium sp. Pests that attack stored grains, such as It is also useful for the immature stage of insects that inhabit. The compound is agriculturally important Also useful as a nematicide to control potential soil nematodes .   For use as an antiparasitic agent in animals, the compounds of the present invention are administered orally or Is administered internally by either injection or as a liquid drench or shampoo. It can be administered locally.   For oral administration, the compound is administered in capsule, tablet or pill form Or, alternatively, they can be mixed with animal feed. The Capsules, tablets and pills include starch, talc, magnesium stearate Alternatively, the active ingredient may be combined with a suitable carrier, such as dicalcium phosphate. It These unit dosage forms are formulated so that a homogeneous mixture or suspension is obtained. , Active ingredients and diluents, fillers, disintegrants, suspending agents and / or binders It is prepared by intimately mixing with a suitable finely divided inert ingredient. Not An active ingredient is one which will not react with the compounds of the invention, which is It is non-toxic to animals that should be treated. Suitable inactive ingredients include starch, lactose Such as soot, talc, magnesium stearate, vegetable gum and vegetable oil. By size and type of animal species to be treated and type and degree of infection Depending on enormous factors, these formulations contain widely varying amounts of active ingredient and And inactive ingredients may be included. The active ingredient simply comprises the compound as a food ingredient. Additives to the bait by mixing or applying the compound to the surface of the bait Can also be administered as. Alternatively, the active ingredient is mixed with an inert carrier. It is also possible to mix the resulting composition with food or to feed directly to the animal. You can also Suitable inert carriers include corn meal, citrus meal, fermentation residues, soy sauce. Includes coarse oil powder and dried grains. The active ingredient has a final composition of 0. 001-5. 0 layer By grinding, stirring, crushing or disintegrating so as to contain a quantity% of active ingredient Mix well with these inert carriers.   The compound may alternatively be formulated as an active ingredient dissolved in an inert liquid carrier. It can also be administered parenterally via inoculation. Inoculation should be intramuscular, intraruminal ( intraruminal), intrathecal or subcutaneous. The inoculation formula should be It consists of the active ingredient mixed with an active liquid carrier. Acceptable liquid carriers include peanut oil , Vegetable oils such as cottonseed oil and sesame oil, as well as solketal and glycerol Includes organic solvents such as Marl. Alternatively, use an aqueous injection formulation Can be. The vegetable oil is the preferred liquid carrier. The final prescription is 0. 00 5- Dissolving or suspending the active ingredient in a liquid carrier so as to contain 20% by weight of the active ingredient To be prepared.   Topical application of the compounds of this invention involves the compound of this invention as an aqueous solution or suspension. This is possible through the use of liquid drinks or shampoos that contain it. These prescriptions are , Generally contains a suspending agent such as bentonite and usually also a defoamer Will be out. 0. Formulations containing 005 to 20% by weight of active ingredient are acceptable. The preferred formulation is 0. It contains from 5 to 5% by weight of the compound of the invention.   The compounds of the present invention are suitable for cows, sheep, horses, dogs, cats, goats, pigs and domestic animals. Antiparasitics for the treatment and / or prevention of helminthic disease in domestic animals such as poultry It is mainly useful as an agent. In addition, these are external materials such as ticks, lice, fleas, etc. It is also useful in the prevention and treatment of parasite infections of these animals by partial parasites. this Have also been effective in treating parasitic infections in humans. In the treatment of such infectious diseases Thus, the compounds of the invention may be used individually or in association with each other antiparasitic agent or other relationship. It can be used in combination with other antiparasitic agents. Best results of the invention required The dose of the compound depends on the species and size of the animal, the type and degree of infection, the mode of administration. It depends on several factors such as the method and the compound used. Single dose or how many At a dose of 0. This was initiated every several days at a dose level of 005 to 50 mg / kg animal body weight. Oral administration of the light compounds generally gives good results. One of the invention A single dose of the compound usually gives the best control, however, reinfection Repeated doses to combat or for unusually persistent parasite species You can also Techniques for administering these compounds to animals are known to those of skill in the veterinary arts. ing.   The compounds of the present invention control agricultural pests that attack crops in the field or in storage Can also be used for The compound is either a growing plant or a harvested grain Applicable when used as a spray, powder, emulsion, etc. These in this manner Techniques for applying the compounds are known to those skilled in the agricultural arts.   The following examples are provided so that the invention might be more fully understood; The present invention is not limited to any case.   Method No. 1; Production and isolation of Marcfortine A   Seed fermentation process:   Seed fermentation is performed by isolating the isolate Penicillium sp. ) U Inoculate with agar plug of C7780 (NRRL 18887). Thaw 3 stoppers Used as an inoculum. GS-7 contains glucose and (Men, Tennessee, USA Memphis, TN, U. S. A. ), Traders Protein Proctor Ann De Gamble Oilseed Products Corporation (Traders Prot ein, Procter & Gamble Oilseed Products Co. ) Pharma Pharma (P harmamedia) ”sold under the registered trademark) consisting of cottonseed flour. Supplement anything Water the medium components with tap water,_FourAdjust to pH 7.2 with OH To adjust. The medium was placed in an amber-full closed flask, 3 per 1000 ml flask. Dispense 00 mL and sterilize by autoclaving at 121 ° C for 30 minutes To do. Each closed flask containing 300 ml of GS-7 medium was placed in penicillium. With 3 agar plugs of the seed (Penicillium sp.) UC 7780 (NRRL 18887) Inoculate and shake on a rotary shaker at 250 rpm at 22 ° C. for 36 hours.   Secondary seed fermentation process:   The mature seed culture is used as an inoculum for the secondary medium at a 0.3% seed ratio. two The following medium was used for each liter of reverse osmotic grade water (CyPyCy Internal Registered as Cerelose by C.P.C.International. 25 g of glucose monohydrate (sold as standard), ("Pharmamedia") 25g cotton seed flour (sold under a registered trademark), MgCl₂・ 6H₂O329.8mg , MnSO_Four・ H₂O11.4mg, FeSO_Four・ 7H₂O3.2mg, Na₂MoO_Four ・ 2H₂O1.8mg, CaCl₂・ 2H₂O367.6mg, NaCl84.2mg , KCl 5.8mg, ZnSO_Four・ 7H₂O0.1mg, CoCl₂・ 6H₂O 0.1 mg, CuSO_Four・ 5H₂O3.1 mg and (SAG-471 antiform (An tifoam) sold under the registered trademark) silicone antifoam 0.5 ml . Sufficient medium components in 200 liters of secondary seed medium are hydrolyzed in reverse osmotic grade water, 2 50 L-Approximately 190 l capacity in fermentor. After the formulation, the pH of the medium was adjusted to N H_FourPH with OH Adjust to 7.2, then sterilize the medium for 30 minutes at 121 ° C. Mature primary-species Two closed flasks of culture are used as inoculum at 0.3% seed ratio. Secondary seed culture was aerated to 125 slm, 5 psig back pressure, 250 rpm, 22 ° C. And incubate for 36 hours.   Production fermentation process:   The production medium is beet molas per liter of reverse osmotic grade water. s) 50g, (Menhaden Select Fish Meal  16g of fish meal (sold under the trademark Fish Meal), (Fidco dco) sold under the registered trademark) Yeast extract 10 g, MgCl₂・ 6H₂O 329.8 mg, MnSO_Four・ H₂O11.4mg, FeSO_Four・ 7H₂O3.29m g, Na₂MoO_Four・ 2H₂O1.8mg, CaCl₂・ 2H₂O367.6mg, N aCl84.2mg, KCl5.8mg, ZnSO_Four・ 7H₂O0.1mg, CoC l₂・ 6H₂O0.1mg, CuSO_Four・ 5H₂O3.1 mg and (SAG-471 Silicone defoamer sold under the registered trademark Antiform) Consists of 0.5 ml.   Add enough medium components to 5,000 liters of medium with reverse osmotic grade water to obtain 5.0 Approximately 4,700 l capacity in a 00 L fermentor. After formulation, adjust the pH of the medium to K The pH is adjusted to 7.0 with OH and the medium is then sterilized at 123 ° C. for 30 minutes. Success The mature secondary-seed culture is used as an inoculum at a 1.0% seed ratio. 2 the culture Ink, 500 slm aeration, 5 psig back pressure, 250 rpm, 22 ° C for 96 hours To incubate.   Isolation of Marcfortine A:   Collect 4900 L fermentation volume into a collection container by passing through a high shear mixer . After transfer, add 4% weight / volume diatomaceous earth and 1/2 volume methylene chloride It Then, the collected solution is filtered using a pressure filter. 10% volume of filter cake Wash twice with methylene chloride.   The resulting filtrate is decanted to remove the water (aqueous) phase. Then the remaining raw The product-rich methylene chloride phase is concentrated to 44 L volume. Then 20% concentrated Reduction Make up the concentrate with a volume (9 L) of methylene chloride and diatomaceous earth on the filter. Raise.   53 L of the finished concentrate was subjected to silica gel chromatography and crystallization. Then, it is further purified from other components to isolate Marcfortine A.   Four approximately equal aliquots of the finished concentrate prior to chromatography Divide into Use 25 Kg of dry silica gel (bed volume 59 L) for each aliquot Chromatography on a freshly packed 9 '' diameter column separated from the column. negative Collect the loaded column as a 20 L fraction with 30 and 40% eluate. 120L 10% acetone in methylene, 120% acetone 120% in methylene chloride L, 30% acetone in methylene chloride 120 L, 40% aceto in methylene chloride Elute with 160 L of acetone and 130 L of acetone. For example, 6 in methylene chloride Using a solvent system consisting of% isopropanol and 0.3% ammonium hydroxide By TLC deploying Whatman LK6DF silica gel plate Monitor the eluate. (Contains a small amount of marcfortine D The fraction of Marcfortine A is crystallized from acetone. Suitable picture Minutes (40-100 L) are concentrated under reduced pressure to a volume of about 5 L. Then, the solution ( Or a light slurry) is transferred to a rotary evaporator and concentrated under reduced pressure. Continue. During the concentration process until the methylene chloride is completely replaced, a few L parts of Add the seton. Refrigerate the resulting acetone slurry (of about 1 L capacity) overnight, Crystals of Marcfortine A were collected, washed with some small portions of cold acetone and vacuumed. To dry. Such concentrates may be contaminated with a few percent of Marcfortine D. It From methylene chloride / acetone (replacing methylene chloride as described above) Pure Marcfortine A is obtained by repeated recrystallization.   Isolation of Marcfortine D:   Collect 4900 L of fermentation volume into a collection container by passing through a high shear mixer To do. After transfer, 4% weight / volume diatomaceous earth and 1/2 volume methylene chloride Added. The harvested solution is then filtered using a pressure filter. 10% filter cake Wash twice with volume of methylene chloride.   The resulting filtrate is decanted to remove the water (aqueous) phase. Then the remaining raw The product-rich methylene chloride phase is concentrated to 44 L volume. Then 20% concentrated The concentrate using a reduced volume (9 L) of methylene chloride and diatomaceous earth on the filter. To finish.   53 L of the finished concentrate was subjected to silica gel chromatography and crystallization. It is further purified to separate marcfortine A from other components.   Prior to chromatography, the finished concentrate is divided into four approximately equal aliquots. Divide. Each aliquot from 25 Kg of dry silica gel (bed volume 59 L) Chromatography on prepared fresh packed 9 '' diameter column. load The collected column was collected with 30 and 40% eluate as 20 L fractions. 120 L of 10% acetone in Tylene, 120 L of 20% acetone in methylene chloride , 120% 30% acetone in methylene chloride, 40% acetone in methylene chloride Elute with 160 L and 130 L of acetone. For example, 6% in methylene chloride A solvent system consisting of isopropanol and 0.3% ammonium hydroxide was used to process the wax. The eluate was collected by TLC on a Tutman LK6DF silica gel plate. To monitor. The fraction of Marcfortine A containing Marcfortine D is concentrated. This 1 g of the above substance is dissolved in formic acid (20 mL, 93%) and left at room temperature for 16 hours. After removing volatile components under reduced pressure, the residue was subjected to silica gel chromatography ( 1:20 MeOH: CH₂Cl₂) And add Marcfortine D (100 mg) to white Obtained as a colored solid. The structure of the product was confirmed by NMR spectrum and mass spectrometry. Can be confirmed. Elemental analysis C₂₈H₃₅N₃O₃+ H, HRMS (FAB) M / Z [M + H]: Calculated value 462.2756; Measured value: 462.2739   Method 1A  Production and isolation of marcfortine A and C   Primary seed fermentation process:   Seed fermentation is an isolate of Penicillium sp. Stored on liquid nitrogen. Inoculate with an agar plug of UC7780 (NRRL 18887). 3 agar plugs Is thawed and used as an inoculum for 100 ml of GS-7 seed medium. (US Tennessee -State, Memphis, TN, U.S.A., Traders Protein, Proctor A Gambling Oilseed Products Corporation (Traders Pr otein, Procter & Gamble Oilseed Products Co.) (Pharmamedia) GS-7 is a solid material sold under the registered trademark "Pharmamedia". It consists of lucose and cottonseed flour. After formulating, NH_FourAdjust the pH to 7. Adjust to 2. A 100 ml volume of the 500 ml Amberflu fermentation flask Autoclave the medium for 30 minutes. Inoculate with sterile GS-7 as above This is shaken at 250 rpm and 23 ° C. for 35-58 hours.   Production fermentation process (shaking flask):   The mature seed culture is used as an inoculum for the production medium at a 1% seed ratio. The production The medium was used per liter of tap water (Norwich, N.Y., New York, USA). U.S.A.) by Sheffield Products Pontonized Milk Nutrient ” 25 g of enzymatically degraded casein (sold under the registered trademark), DE, Minnesota Detroit, MI to Difco Laboratories From "BACTO Yeast Extract Code: 0127 127) "sold under the registered trademark)) yeast extract 2.5 g. After fermentation First, the pH of the production medium is adjusted to 7.0 with potassium hydroxide. Then this Add 100 ml of medium to a 500 ml baffle fermentation flask and autoclave for 30 minutes. Put it in the oven. Sterile production medium was injected as above and at 250 rpm, 21 ° C. Shake for 7-14 days.   Production fermentation process (Labraferm tank):   Use mature seed culture as an inoculum for sterile production medium at 0.5% seed ratio . The production medium is as described above. After adjusting the pH to 7.0 with KOH , (New Brunsvik Scientific Corporation, Inn Corporate (New Brunswick Scientific Co., Inc.) Labrafers Autoclave 90 liters of this medium for 90 minutes. The tank is 0.5 % Seed ratio and stir at 500 rpm, 20 ° C. for 5-9 days. Ventilation rate Is Maintain between 10-15 L / min.   Isolation of Marcfortine A and C:   Whole fermentation broth (35 l) in a large commercial Waring Blende Dissociate slowly in r) and then blend with an equal volume of methylene chloride. this The mixture is stored under refrigeration overnight and then centrifuged to break the emulsion. Got The clear methylene chloride phase which has formed is pulled up and evaporated under reduced pressure. In methylene chloride A concentrated solution of the residue (37.4 g) in silica gel packed in methylene chloride (1K g) Apply to the slurry column. The column is loaded with increasing concentrations of acetate in methylene chloride. Elute with Cetone (10%, 20%, 30%, 40% and 50% acetone). Fractions were monitored by TLC, appropriate fractions were evaporated and crystallized from acetone. To give Marcfortine A and Marcfortine C.   Method 1B  Production and isolation of marcfortine A and C   Seed fermentation process:   Seed fermentation is an isolate of Penicillium sp. Stored on liquid nitrogen. Inoculate with an agar plug of the UC7780 (NRRL 18887) isolate. Three Thaw the agar plug and use as an inoculum for 100 ml of GS-7 seed medium. GS-7 And glucose added at a tap water concentration of 25 g / L each (Tennessee, USA, Memphis, TN, U.S.A., Traders Protein, Proctor A Gambling Oilseed Products Corporation (Traders Pr otein, Procter & Gamble Oilseed Products Co.) (Pharmamedia) "is a solid material sold under the registered trademark)] From cotton seed flour Become. After formulation, adjust the pH of GS-7 to NH_FourAdjust to 7.2 with OH. Fifty The medium was turned on for 30 minutes in a volume of 100 ml placed in a 0 ml Amberful fermentation flask. Put it in the autoclave. Sterile GS-7 was inoculated as above and this was 250 r Shake at pm, 23 ° C. for 35-58 hours.   Production fermentation process (shaking flask):   The mature seed culture is used as an inoculum for the production medium at a 1% seed ratio. Production culture The ground is 20 g glucose per liter of tap water, 15 ml glycerol, (US C State, Memphis, TN, U.S.A., Traders Protein, Proctor And Gamble Oilseed Products Corporation (Trader s Protein, Procter & Gamble Oilseed Products Co.) 20g cotton seed flour, sold under the registered trademark "Pharmamedia", soybean Meal 10g and K₂HPO_FourIt consists of 3 g. After formulating, add potassium hydroxide Use to adjust the pH of the production medium to 6.8. Then, this medium is l Autoclave for 30 minutes at the volume of 100 ml contained in the baffle fermentation flask Hang on. Inoculate aseptic production medium as described above and at 250 rpm, 21 ° C for 7 -Shake for 14 days.   Production fermentation process (Labrafarm tank):   Use mature seed culture as an inoculum for sterile production medium at 0.5% seed ratio . The production medium is as described above. After adjusting the pH to 7.0 with KOH, 10 L of this medium (12 L of New Brunswick Scientific ・ Corporation, Incorporated (New Brunswick Scientific Co., In c.) Company) Put in a labra farm tank and autoclave for 90 minutes. 0. Inoculate at 5% seed ratio and stir at 500 rpm at 20 ° C for 5-9 days. Ventilation speed Maintain the rate between 10-15 L / min.   Isolation of Marcfortine A and C:   Whole fermentation broth (35 l) at low speed in a large commercial Waring blender Dissociate and then blend with an equal volume of methylene chloride. Place the mixture under refrigeration Stored overnight and then centrifuged to break the emulsion. Obtained transparent The methylene chloride phase is pulled up and evaporated under reduced pressure. Residue in methylene chloride (3 Silica gel (1 Kg) slurry filled with methylene chloride. Column. The column was loaded with increasing concentrations of acetone (methylene chloride Elute with 10%, 20%, 30%, 40% and 50% acetone). Fraction is Monitor by TLC and evaporate the appropriate fractions and crystallize from acetone to give a solid. Lukfortin A and Marcfortine C are obtained.   Synthesis of 14-Substituted Marcfortine   Marcfortine A (Formula 1a, Chart A) was treated with cyanogen iodide to give 16α -Iodo-17β-cyanomarcfortine A and 16β-iodo-17α-cyanomer A mixture of Lucfortine A (Formula 5) was obtained, which was subjected to silica gel chromatography. Can be separated by Deiodination of this mixture with potassium hydroxide in methanol Hydrogenation gave 16,17-dehydro-17-cyanomarcfortine A (formula 6) And oxidize it to 17-ketomarcfortine A (formula 7) with serine dioxide It The introduction of the double bond between C15 and C16 introduces a selenidation (chlorination) at the 16-position. Phenylselenyl and LDA) followed by oxidation of the selenium intermediate with hydrogen peroxide. Will be achieved. After that, the phenyl selenic acid was removed to give 15,16-dehydro- 17-ketomarcfortine A (Formula 8) is obtained. This compound is 14α-hydroxy It is a key intermediate in the synthesis of Marcfortine A (Formula 10), which involves two different synthetic routes. Can be converted to the 14α-hydroxymarcfortine A by any of the   In the first route, potassium bis (trimethylsilyl) amide and 16- Use 2-phenylsulfonyl-3-phenyloxaziridine with position oxidation The 14-position of allyl group of the above compound gives the required 14α-hydroxy-15,16 -Dehydro-17-ketomarcfortine A (formula 9a) and 14,15-dehydro-1 A mixture of 6-hydroxy-17-ketomarcfortine A (Formula 9b) is obtained. these The two products of are separated by silica gel chromatography. Of formula 9a The compound was prepared according to the present disclosure by lithium aluminum hydride in THF. Compound 14 α-Hydroxymarcfortine A (formula 10) is reduced. Alternatively , A compound of formula 8 (Chart B) was oxidized with serine dioxide in dioxane to give 14α -Hydroxy-15,16-dehydro-17-ketomarcfortine A (formula 9a) and 2,16 mixture of 15,16-dehydro-14,17-diketomarcfortine A (formula 11) Get the compound. These are separated by silica gel chromatography. this Each of these compounds independently represents 14α-hydroxy-17-ketomarcfortine A (formula 12a) converted to: 15,16-double bond with triethyllithium borohydride Compound of Formula 9a by reduction of carbonyl; carbonyl at 14-position with lithium borohydride A compound of formula 11 by reduction of In the latter case, an equal amount of 14β-hydroxy Shi-17-ke Tomarcfortine A (formula 12b) is also produced, which is chromatographically Can be removed more. The compound of formula 12a is a borane tetrahydrofuran (THF) complex. Reduction with the body gives 14α-hydroxymarcfortine A (formula 10).   14α-Hydroxy-15,16-dehydro-17-ketomarcfortine A (formula 9a , Chart C) shows triethyllithium borohydride, 14α-hydroxy-17- Reduce to ketomarkfortin A (Formula 12a). This is oxalyl chloride and 14,17-diketomark by Swern oxidation with DMSO Convert to Hortin A (Equation 13). Methyl bromide in Grignard reaction Treated with sium, 14α-hydroxy-14β-methyl-17-ketomarcfortine A (formula 14a) and 14β-hydroxy-14α-methyl-17-ketomarkol A mixture of Chin A (formula 14b) is produced which is chromatographed on silica gel. Therefore, it separates. The ratio of the products depends on the solvent used: methylene chloride, respectively. Gives a ratio of 6: 1, whereas THF gives a ratio of> 50: 1. Of Equation 13a Reduction of the compound with lithium aluminum hydride gives 14α-hydroxy-14β -Methylmarcfortine A (Formula 15) is obtained.   14α-Hydroxymarcfortine A (Formula 10, Chart D) Swellic Acid 14-ketomarcfortine A (formula 16) was obtained by Reduction to 14-β-hydroxymarcfortine A (Formula 17) with thorium. 14- Ketomarcfortine A (formula 16) was treated with ethylmagnesium bromide in a Grignard reaction. When treated with sium, 14α-hydroxy-14-ethylmarcfortine A (formula 1 9) is generated. 14α-Hydroxymarcfortine A (formula 10) was added to m-chlorope When treated with luoxybenzoic acid, 14α-hydroxymarcfortine A N-oxy Generate the side (Formula 18). 14β-Methylmarcfortine A can be dehydrogenated Thus, it can be produced from 14α-hydroxy-14β-methylmarcfortine A. Scratch Then, in the presence of a base, 14α-hydroxy-14β-methylmarcfortine A was added to Treat with phenylchlorothionoformate. 14α-hydroxy-14β-meth This thionoformate derivative of rumarcfortine A is tri-n-butyltin hydride When reduced with, 14β-methylmarcfortine A is produced.   Alternatively, 14α-hydroxymarcfortine A is derived from marcfortine A It can also be synthesized (Chart E). Marcfortine A as an aqueous tetrahydrophobic Treatment with sodium bicarbonate and iodine in orchids produces 17-ketomarkholch A (formula 7), which is obtained by using LDA and phenyl disulfide. And then disulfenylated to 16-dithiophenyl-17-ketomarcfortine A (Formula 20, Chart E) can be obtained from Marcfortine A in 60% yield . When oxidized with m-chloroperoxybenzoic acid, 16-phenyl-16-sulfoxy Phenyl-17-ketomarcfortine A (formula 21) is produced, which is refluxed with toluene. 15,16-dehydro-16-thiophenyl-17-ketomarkholch A (formula 22) is obtained. Subsequent treatment with m-chloroperoxybenzoic acid gives 1 5,16-dehydro-16-sulfoxyphenyl-17-ketomarcfortine A (formula 2 3) which is rearranged by using diethylamine in methanol Then, 15,16-dehydro-14α-hydroxy-17-ketomarcfortine A ( Generate equation 9a).   14α-Hydroxy-15α-methylmarcfortine A (Formula 35, Chart G) Is 15,16-dehydro-14α-hydroxy-17-ketomarcfortine A (formula 9 a, chart G). Thus, 15,16-dehydro-14α-hydride Roxy-17-ketomarkfortin A (formula 9a) was replaced with methylmagnesium bromide or When treated with either dimethyl copper lithium, 15α-methyl-14α-hydroxy Si-17-ketomarcfortine A (formula 34) is produced and is prepared using borane-dimethyls 15α-Methyl-14α-hydroxymarcfortine A when reduced with a rufide complex (Equation 35) is generated. Swell acidification with oxalyl chloride and DMSO According to 15α-methyl-14α-hydroxy-17-ketomarcfortine A (formula 34) is converted to 15α-methyl-14,17-diketomarcfortine A (formula 36) It When treated with methylmagnesium bromide in the Grignard reaction, 15α- Methyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A (Formula 37 ) Is produced and reduced with borane-dimethyl sulfide complex to give 15α-methyl This produces -14α-hydroxy-14β-methylmarcfortine A (Formula 38).   Using these previously described methods, 14-substituted marcfortine B, C and D derivatives A conductor can be created.16-iodo-17-cyanomarcfortine A (as a mixture of diastereomers Preparation of formula 5)   Solid cyanogen iodide (11.7 g, 76.5 mmol) was added to CHCl.₃(150 mL) To the solution of Marcfortine A (10.5 g, 22 mmol) in Is heated to reflux until all Marcfortine A is consumed (about 5 hours). Got Cool the black solution to room temperature, CH₂Cl₂Diluted with (100 mL) and saturated NaHCO 3.₃ Washed with, then Na₂SO₃Wash with solution. The organic phase is separated and_FourAbove Dry and concentrate to dryness. The resulting crude solid is chromatographed on silica gel. (3: 2-EtOAc: hexane), 16-iodo-17-cyanomarcfortine A (12.5 g, 90%) is obtained as a white powdery solid. The structure of the product is the nucleus It can be confirmed by magnetic resonance spectrum and mass spectrometry.Preparation of 16,17-dehydro-17-cyanomarcfortine A (Formula 6)   16-iodo-17-cyanomarcfortine A (9.5 g, 15 mmol) in Me Dissolve in OH (150 mL) and add aqueous KOH (45%, 3 mL). reaction The mixture is stirred at room temperature for 2 hours. Water was added and the resulting precipitate was filtered off. It was collected, washed with water and dried under vacuum overnight to give 16,17-dehydro-17-cyanomer. Lucfortine A (6.6 g, 75%) is obtained as a white powder. The structure of the product is It can be confirmed by nuclear magnetic resonance spectrum and mass spectrometry. MS (FAB) M / Z [M + H]: 501Preparation of 17-ketomarkfortin A (Formula 7)   Selenium dioxide (2.9 g, 26 mmol) in 95% EtOH (100 mL) 16,17-dehydro-17-cyanomarcfortine A (6.0 g, 10 mmol ) Solution and the reaction mixture is stirred at room temperature for 2 hours. Saturated NaHCO₃(1 The reaction is quenched by the addition of 00 mL). The resulting mixture is CH₂ Cl₂Extract with (2 x 200 mL). Combine the extracts and dry (MgSO_Four), Concentrate to give 7 g of crude product. Silica gel chromatography ( EtOAc) 17-ketomarkfortin A (3.6 g, 75%) as a white solid. Get as. The structure of the product was confirmed by nuclear magnetic resonance spectroscopy and mass spectrometry. I can accept it. Elemental analysis C₂₈H₃₃N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 492.2498; Found: 492.2478.   Alternatively, and more preferably, by using p-toluenesulfonic acid Thus, the title compound can also be synthesized. Thus, p-toluenesulfonic acid The hydrate (1 g) was added to 16,17-dehydro-17-sihine in 95% MeOH (50 mL). Add to the solution of Anomarkfortin A (10 g) and let the reaction mixture at room temperature for 1 hour. Stir. Triethylamine is added to the mixture and the solvent is evaporated. 1 residue Triturate with 0% aqueous sodium carbonate (100 mL) and filter solids. And dry to give the title compound as a solid (90% yield). The structure of the product is It can be confirmed by nuclear magnetic resonance spectrum and mass spectrometry.Preparation of 15,16-dehydro-17-ketomarcfortine A (Formula 8)   Hexane (1.6 M, 9.9 mL, 15.4 mmol) and diisopropyl acetate Lithium from a solution of n-butyllithium in min (2.2 mL, 15.7 mmol). A solution of mudiisopropylamide is prepared. This is anhydrous tetrahydrofuran (T HF, 20 mL) and cooled to -78 ° C. In anhydrous THF (20 mL) A solution of 17-ketomarcfortine A (2.0 g, 4.1 mmol) was added dropwise to the reaction. The mixture is warmed to -40 ° C for 1 hour. The mixture was cooled again to -78 ° C and treated with fe-chloride. Treat with nitselene (19 mg, 5.2 mmol) dropwise. After 5 minutes, Saturated NaHCO₃Quench with CH₂Cl₂Extracted with and dried (MgSO_Four) And concentrate To give a yellow solid, which can be used without further purification. This substance Is dissolved in THF (150 mL), and H is added at 0 ° C.₂O₂(30%, 1.5mL) Make sense. The cold bath is removed and the reaction mixture is stirred at room temperature for 30 minutes. NaOH (1 The reaction is quenched by adding N, 100 mL). CH the mixture₂ Cl₂Extract with (2 x 200 mL). Combine the extracts and dry (MgSO_Four), Concentrate to give the crude product. This material was chromatographed on silica gel (EtOAc) Purified by Ac), 15,16-dehydro-17-ketomarcfortine A (1.3 g, 65%) was added as a white solid. Obtain as a shape. Confirm product structure by nuclear magnetic resonance and mass spectrometry . Elemental analysis C₂₈H₃₁N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 490.2342; Found 490.2345.14α-Hydroxy-15,16-dehydro-17-keto using oxazolidine chemistry Preparation of Marcfortine A (Formula 9a)   A solution of potassium bis (trimethylsilyl) amide in toluene (0.5M, 1 mL, 0.5 mmol) was added to 15,16-dehydro in THF (2 mL) at -78 ° C. Add dropwise to a solution of -17-ketomarkfortin A (66 mg, 0.14 mmol) . The resulting yellow thick solution is warmed to -40 ° C for 1 hour. The reaction mixture is -78 ° Cool to room temperature, stir for 15 minutes, then 2-phenylsulfoni A solution of le-3-phenyloxaziridine (42 mg, 0.16 mmol) is added dropwise. Process by doing. NaHCO₃Quench the reaction by adding After that, the mixture is stirred for 5 minutes. CH the mixture₂Cl₂Extract with (2 × 25 mL). Combine the extracts and dry (MgSO_Four) And concentrate to give the crude material. this Was purified by preparative thin layer chromatography (silica gel, EtOAc) to give 1 4α-hydroxy-15,16-dehydro-17-ketomarcfortine A (8 mg, 1 2%) as a white solid. Structure, nuclear magnetic resonance spectrum and mass spectrometry Can be confirmed by Elemental analysis C₂₈H₃₁N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated: 506.2291; Found: 506.2280 14,15-dehydro-16-hydroxy-17-ketomarcfortine A was also obtained from the layer (12 mg, 20%). Its structure can be confirmed by nuclear magnetic resonance spectroscopy. It14α-Hydroxy-15,16-dehydro-17-ketomark using selenium dioxide Hortin A (Formula 9a), 15,16-dehydro-14,17-diketomarkfortin A (formula 11) and 14,15-dehydro-16,17-diketomarcfortine A ( Preparation of formula 24)   15,16-dehydro-17-ketomarcfortine A (1.29 g, 2.6 mmol ) Was dissolved in p-dioxane (30 mL) and treated with selenium dioxide (390 mg). To do. The mixture is refluxed for 1 hour and the solvent evaporated under vacuum. The residue was converted into methylene chloride (3 Triturate with 0 mL) and filter. The filtrate is concentrated and the residue is washed with silica gel. 14α-Hydroxy-subjected to matography (1:20 MeOH: EtOAc) Solidified 15,16-dehydro-17-ketomarcfortine A (430 mg, 32%) Get as a thing. 15,16-dehydro-14,17-diketomarcfortine A (formula 1 1,212 mg, 16%) is also obtained by chromatography. 14,15-Dehi Doro-16,17-diketomarcfortine A (formula 24, 106 mg, 8%) Get from Matography. The structures of these products are the nuclear magnetic resonance spectra and And mass spectrometry.14α-Hydroxy-15,16-dehydro-17-ketomarcfortine A (formula 9a) Of 15 to 16-dehydro-14,17-diketomarcfortine A (formula 11)   14α-Hydroxy-15,16-dehydro-17-ketomarcfortine A (60 m g, formula 9a) was dissolved in methylene chloride (10 mL) and manganese dioxide (60 mg ). The mixture is stirred at room temperature for 1 hour and concentrated. Of the residue on silica gel 1 by preparative thin layer chromatography (50% methylene chloride in EtOAc) 5,16-dehydro-14,17-diketomarcfortine A (Formula 11, 35 mg, 6 0%). The structures of these products are determined by nuclear magnetic resonance spectroscopy and mass spectrometry. Can be confirmed byExample 1.14 Preparation of α-hydroxymarcfortine A (Formula 10)   14α-Hydroxy-15,16-dehydro-17-ketomarcfortine A (20 m g, 0.040 mmol) in THF (5 mL) and hydrogenated in THF at 0 ° C. Treat with a solution of lithium aluminum (1M, 0.11 mL, 0.11 mmol) It NaHCO₃After adding (10%) solution, the mixture is left at 0 ° C. for 0.5 hours. Stir. CH the mixture₂Cl₂Extract with (2 x 10 mL). Combine the extracts, Dry (MgSO_Four) And evaporate the solvent. Thin layer chromatography for preparative separation of residue on silica gel 14α-Hydroxymatrix was subjected to a matography (10% MeOH in EtOAc). Lucfortine A (3 mg, 15%) is obtained as a white solid. The structure of the product is It can be confirmed by nuclear magnetic resonance spectrum and mass spectrometry. Elemental analysis C₂₈H₃₅N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 4942655; Found: 4942655.14α-Hydroxy-15,16-dehydro-17-ketomarcfortine A (formula 9a) Of 14α-hydroxy-17-ketomarcfortine A (formula 12a) from   14α-Hydroxy-15,16-dehydro-17-ketomarcfortine A (50 m g, 0.1 mmol) in THF (5 mL) and hydrated with water at -78 ° in THF. Treat with a solution of triethyllithium iodide (1M, 0.7 mL). Mix -78 Stir at 0.5 for 0.5 hours. The reaction was added by adding MeOH (1 mL). Quench and concentrate the mixture. The obtained solid is subjected to silica gel chromatography. -(1:20 MeOH: CH₂Cl₂), 14α-hydroxy-17-ketomal Cufortin A (43 mg, 86%) is obtained as a white solid. The structure of the product is It can be confirmed by NMR spectrum and mass spectrometry. Elemental analysis C₂₈H₃₃N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated: 508.2447; Found: 508.243714 from 15,16-dehydro-14,17-diketomarcfortine A (formula 11) Preparation of α-hydroxy-17-ketomarcfortine A (formula 12a)   15,16-dehydro-14,17-diketomarcfortine A (470 mg, 0.9 (3 mmol) in THF and dissolved in lithium borohydride in THF at room temperature. Treat with liquid (1M, 2 mL). NaHCO₃Mix after adding the solution (10%) Stir for 2 hours. CH the mixture₂Cl₂Extract with (2 x 20 mL). Extract And dry (MgSO_Four) And evaporate the solvent. The residue consists of two epimers A mixture was included, which was subjected to silica gel chromatography (1:20 Me. Easily separable by OH: ETAc): 14α-hydroxy-17-ketomal Kfortin A (90 mg, 19%) and 14β-hydroxy-17-ketomark Hortin A (94 mg, 20%). The structures of both products are NMR spectra and It can be confirmed by mass spectrometry.14α-Hydroxy-17-ketomarcfortine A 14α-Hydride from Formula (12a) Preparation of Roximarkfortin A (Formula 10)   14α-Hydroxy-17-ketomarcfortine A (413 mg, 0.81 millimolar Is dissolved in THF (20 mL) and the boron-THF complex in THF is dissolved at 0 °. Treat with solution (1M, 2.43 mL). The mixture is stirred for 2.25 hours. MeO After adding H (3 mL), the mixture is stirred for 0.5 h. The solvent was evaporated Afterwards, the residue was chromatographed on silica gel (1:16 MeOH: EtOAc). 14α-hydroxymarcfortine A (250 mg, recovered starting material) 92% yield) and 14α-hydroxy-17-ketomarcfortine A (Starting material, 140 mg, 34%) is obtained.Preparation of 14,17-diketomarkfortin A (Formula 13)   Anhydrous CCl₂Add a solution of oxalyl chloride (40 μL) in (5 mL) to -78 ° With dimethyl sulfoxide (45 μL). Mix the mixture at -78 ° for 1 hour Stir for a while. CH₂Cl₂14α-Hydroxy-17-ketomarkol in (2 mL) A solution of Chin A (27 mg) is added dropwise. Stir reaction mixture at -78 ° for 20 minutes To do. Triethylamine (0.3 mL) was added to the reaction mixture which was warmed to room temperature for 20 minutes. Add Mixture with 10% Na₂CO₃(10 mL) and CH₂Cl₂(10 mL) Distribute between. Dry the organic layer (MgSO_Four) And concentrate. Silica gel residue Chromatography (1:20 MeOH: CH₂Cl₂) Attached to 14,17-diketo Marcfortine A (22 mg, 80%) is obtained as a white solid. Product structure Is the NMR spectrum And mass spectrometry. Elemental analysis C₂₈H₃₁N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated: 506.2291; Found: 506.2280Of 14α-hydroxy-14β-methyl-17-ketomarcfortine A (formula 14a) Preparation   -78 ° CH₂Cl₂Solution of 14,17-diketomarkfortin A in (5 mL) (16 mg, 0.032 mmol) at -78 ° C in Et.₂Methyl bromide in O Treat with a solution of sium (3M, 0.16 mL, 0.48 mmol). The resulting mixture The mixture is stirred at -78 ° for 0.5 hours. 10% Na₂CO₃Add (a few drops) Quench the reaction. CH the mixture₂Cl₂Dilute with (10 mL) And dry (MgSO_Four) And concentrate. The residue was chromatographed on silica gel (1 : 20 MeOH: CH₂Cl₂), 14α-hydroxy-14β-methyl-17 -Ketomarkfortin A (8mg, 50%, R_f= 0.25) as a white solid obtain. The structure of the product can be confirmed by NMR spectrum and mass spectroscopy. Elemental analysis C₂₉H₃₅N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated: 522.2604; Found: 522.2620 Further, from the layer, 14β-hydroxy-14α-methyl-17-ketomarcfortine A ( 1.2 mg, 7%, R_f= 0.4) is also obtained as a white solid. The structure of the product is N It can be confirmed by MR spectrum and mass spectrometry. Elemental analysis C₂₉H₃₅N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated: 522.2604; Found 522.2630 The product thus obtained in a ratio of 6: 1 is CH₂Cl₂THF as the solvent instead of In the case of the above, the ratio is increased to over 50: 1 and the yield is increased to 80%.Example 2: Preparation of 14α-hydroxy-14β-methylmarcfortine A (Formula 15) Made   14α-Hydroxy-14β-methyl-17-keto-markho in THF (5 mL) A solution of rutin A (5 mg, 0.01 mmol) was added to the hydrogenated alkane in THF at 0 °. Treat with a solution of lithium minium (1M, 0.03 mL, 0.03 mmol). NaHCO₃After adding the solution (10%), the mixture is stirred at 0 ° C. for 0.5. Mixed CH₂Cl₂Extract with (2 x 5 mL). Combine the extracts and dry (MgSO_Four ) And evaporate the solvent. Preparative thin layer chromatography of the residue on silica gel. (1:20 MeOH: CH₂Cl₂), 14α-hydroxy-14β-methylmer Lucfortine A (2 mg, 40%) is obtained. The structure of the product is NMR spectrum And can be confirmed by mass spectrometry. Elemental analysis C₂₉H₃₇N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 508.2811; Found: 508.2816Preparation of 14-ketomarkfortin A (Formula 16)   Anhydrous CH₂Cl₂Add a solution of oxalyl chloride (150 μL) in (20 mL) to -7 Treat with 8 ° DMSO (170 μL). The mixture is stirred at -78 ° for 1 hour It CH₂Cl₂14α-Hydroxymarcfortine A (110 mg) in (5 mL) ) Is added dropwise. The reaction mixture is stirred at -78 ° for 20 minutes. In 20 minutes Triethylamine (1 mL) is added to the reaction mixture warmed to room temperature. 1 mixture 0% Na₂CO₃(20 mL) and CH₂Cl₂Distribute between (20 mL). Dry the organic layer (MgSO_Four) And concentrate. The residue is chromatographed on silica gel. -(1:25 MeOH: CH₂Cl₂), 14-ketomarkhortin A (8 2 mg, 75%) as a white solid. The structure of the product is NMR spectrum And can be confirmed by mass spectrometry. Elemental analysis C₂₈H₃₃N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 4922.498; Found 4922510.Example 3: Preparation of 14β-Hydroxymarcfortine A (Formula 17)   A solution of 14-ketomarkfortin A (10 mg) in MeOH (2 mL) was added to 0 Treat with sodium borohydride (5 mg). NaHCO₃Solution (10%) After the addition, the mixture is stirred at 0 ° for 0.5 hours. CH the mixture₂Cl₂Extracted with (2 x 10 mL). Combine the extracts and dry (MgSO_Four) And evaporate the solvent It Preparative thin layer chromatography of the residue on silica gel (1:16 MeOH: ETAc) to obtain 14β-hydroxymarcfortine A (5 mg, 50%) obtain. The structure of the product can be confirmed by NMR spectrum and mass spectroscopy. Elemental analysis C₂₈H₃₅N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 4942655; Found: 4942655.Example 4: Preparation of 14α-hydroxymarcfortine A N-oxide (Formula 18)   CH₂Cl₂Of 14α-hydroxymarcfortine A (15 mg) in (3 mL) The solution is treated with m-chloroperoxybenzoic acid (15 mg) at 0 °. mixture Was stirred at 0 ° for 0.5 hours, then treated with triethylamine (30 μL) and concentrated. Contract. Preparative thin layer chromatography of the residue on silica gel (1: 8 MeOH : CH₂Cl₂), 14α-hydroxymarcfortine A N-oxide (12 mg, 80%). The structure of the product can be confirmed by mass spectrometry. Elemental analysis C₂₈H₃₅N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated value: 510.2644; Measured value: 510.2615Example 5: Preparation of 14α-hydroxy-14β-ethylmarcfortine A (Formula 19) Made   A solution of 14-ketomarkfortin A in THF (5 mL) at -78 ° (25 mg , 0.05 mmol), Et at −78 °₂A solution of ethylmagnesium bromide in O ( 3M, 0.15 mL, 0.45 mmol). The resulting mixture is -78 ° C Stir at 0.5 hour. The reaction mixture is warmed to room temperature for 20 minutes. 10% Na₂ CO₃Quench the reaction by adding (a few drops). CH the mixture₂C l₂Dilute (10 mL) and dry (MgSO_Four) And concentrate. The residue is washed with silica gel. Romanography (1:20 MeOH: CH₂Cl₂), 14α-hydroxy Ci-14β-ethylmarcfortine A (10 mg, 45%) was obtained as a white solid. It The structure of the product can be confirmed by NMR spectrum and mass spectroscopy. Elemental analysis C₃₀H₃₉N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 522.2968; Measured: 522.298314α-Hydroxy-14β-methylmarcfortine A-14β-methylmark from A Preparation of Hortin A   A solution of potassium bis (trimethylsilyl) amide in toluene (0.5M, 1 mL, 0.5 mmol) was added to 14α-hydroxy- in THF (2 mL) at -78 °. Add dropwise to a solution of 14β-methylmarcfortine A (66 mg, 0.14 mmol). It The resulting pale yellow thick solution is warmed to -40 ° for 1 hour. The reaction mixture is -78 ° Cooled to room temperature, stirred for 15 minutes, then phenylchlorothiono in THF (2 mL). Worked by adding a solution of formate (0.094 mL, 0.7 mmol) dropwise. To do. Remove the dry ice bath after 10 minutes. After reacting for another 3 hours, N aHCO₃The reaction is quenched by the addition of. CH the mixture₂Cl₂so Extract (2 x 25 mL). Combine the extracts and dry (MgSO_Four) And concentrate to a crude Obtain the manufactured substance. By preparative thin layer chromatography (silica gel, EtOAc) It was then purified to give 14α-O-phenoxythiocarbonyl-14β-methylmarkho Get Rutin A.   14α-O-phenoxythiocarbonyl-14β-methyl in toluene (5 mL) To a solution of Marcfortine A (64 mg, 0.1 mmol), AIBN (3.3 mg ) Then tributyltin hydride (54 μL, 0.2 mmol) is added. mixture Reflux the product for 3 hours. After evaporating the solvent, preparative thin layer chromatography ( The residue was purified by silica gel, EtOAc, 14β-methylmarcfortine Get A. The structure can be confirmed by nuclear magnetic resonance spectrum and mass spectrometry.Alternative Synthesis of 17-Ketomarcfortine A (Formula 7, Chart E)   Methanol in refluxed tetrahydrofuran (THF, 2 L) and water (1.25 L). Lukfortin A (65 g, 0.136 mol) and sodium bicarbonate (137 g 1.63 mol), iodine (206 g, 0.81 mol) in THF (1.25 l) ) For more than 1 hour (alternatively, the mixture should be stirred at room temperature for 16 hours). Can be done). After allowing to cool slowly to room temperature (2.5 hours), the reaction was saturated with water. Sodium sulphate (Na₂S₂O₃Quench with 1.5 L) and extract with ethyl acetate (2 × 1 L). Wash the combined organic layers with saturated sodium thiosulfate (1 L), Dry (MgSO_Four), Filter and evaporate overnight in a vacuum oven (65 ° C) to dryness. And 62 g of crude 17-ketomarkfortin A (Formula 7) are obtained as a yellow solid. .¹ 1 H NMR (300 MHz, CDCl₃); δ 7.68 (s, 1H), 6.80 (d, 1H), 6.70 (d, 1H), 6.32 (d, 1H), 4.90 (d, 1H), 3.75 (q, 2H), 3. 23 (t, 1H), 3.09 (s, 3H), 2.80 (d, 1H), 2.65 (d, 1H), 2.49-2.21 (m, 2H), 2.08 (d, 1H), 1.98-1.45 (m, 5H), 1.4 6 (s, 3H), 1.44 (.s, 3H), 1.09 (s, 3H), 0.90 (s, 3H)   Alternatively, ICI can be used instead of iodine.Synthesis of 16-dithiophenyl-17-ketomarcfortine A (formula 20)   The crude 17-ketomarkfortin A (5 g, 10.2 mmol) was added to T at -78 °. N-BuLi (1.6M, 24.8m) via cannula in HF (150mL) L, 0.04 mol) diisopropylamine (0 mL) in THF (100 mL) at 0 ° C. 5.7 mL) 0.041 mol) added dropwise to the prepared LDA solution To do. The reaction mixture is slowly warmed to -50 ° C over 1 hour. Then obtained Treat the thick red-brown mixture with phenyl disulfide (4.4 g, 0.02 mol). It Quench the reaction immediately with saturated sodium bicarbonate solution (100 mL) and wash with sodium chloride. Chilen (CH₂Cl₂, 300 mL). Dry the organic layer (MgSO_Four) And ( Concentrated to 8 g) and chromatographed on silica gel (120 g, eluent) 60% ethyl acetate / hexane) to give the title compound as an off-white solid. Obtained (4.4 g, 61% from Marcfortine A). FAB-MS 708 (M⁺+ H);¹1 H NMR (300 MHz, CDCl₃) δ 7.74 ( s, 1H), 7.71 (d, 2H), 7.64 (d, 2H), 7.45-7.30 (m, 6H), 6. 81 (d, 1H), 6.72 (d, 1H), 6.32 (d, 1H), 4.91 (d, 1H), 3.70 (q, 2H), 3.16 (t, 1H), 3.01 (s, 3H), 2.75 (d, 1H), 2.53 (d t, 1H), 2.35 (dt, 1H), 2.15-1.50 (m, 5H), 1.47 (s, 3H), 1 .45 (s, 3H), 1.06 (s, 3H), 0.82 (s, 3H)16-thiophenyl-16-sulfoxyphenyl-17-ketomarcfortine A (formula 21) Synthesis   CH at -78 ℃₂Cl₂16-dithiophenyl-17-ketomal in (250 mL) In addition to CHFORtin A (10 g, 14 mmol) under a nitrogen atmosphere, CH₂Cl₂(2 M-chloroperoxybenzoic acid (m-CPBA, 64%, 4.2 g in 00 mL) , 15.5 mmol) is added dropwise over 15 minutes. Saturated sodium thiosulfate (200 (mL) immediately quenched the reaction with saturated NaHCO.₃Diluted with (200 mL), CH₂Cl₂ Extract to (200 mL). Dry (MgSO_Four) Followed by concentration under reduced pressure, 1 1 g of crude 16-thiophenyl-16-sulfoxyphenyl-17-ketomarkol Obtain Chin A (Formula 21).¹ 1 H NMR (300 MHz, CDCl₃) δ 8.0-7.29 (m, 11H), 6.80 (d, 1H), 6.70 (d, 1H), 6.31 (d, 1H), 4.90 (d, 1H), 3.68 (d, 1H) ), 3.41 (d, 1H), 3.14 (t, 1H), 3.07 (s, 3H), 2.82 (dt, 1H), 2.80-2.65 (m, 2H), 2.16 (dt, 1H), 2.05-1. 1 (m, 4H), 1.4 7 (s, 3H), 1.43 (s, 3H), 0.96 (s, 3H), 0.83 (s, 3H)16-thiophenyl-15,16-dehydro-17-ketomarcfortine A (formula 22) Synthesis of   Crude 16-thiophenyl-16-sulfoxyphenyl-17-ketomarcfortine Reflux A (formula 21, 11 g) in toluene (250 mL) for 45 minutes and cool to room temperature. Then dilute with saturated sodium bicarbonate (300 mL) and wash with EtOAc (300 mL). Extract with. Dry the organic layer (MgSO_Four) And concentrated to give 10.6 g of crude 16-thio. Phenyl-15,16-dehydro-17-ketomarcfortine A (Formula 22) is obtained. FAB-MS 598 (M⁺+ H); HRMS M / Z (M⁺+ H, C₃₄H₃₅N₃O_FiveS + H₁ ), Calculated value 598.2376, measured value 598.2387.¹ 1 H NMR (300 MHz, CDCl₃) 8.18 (s, 1H), 7.55-7.45 (m, 2) H), 7.29-7.45 (m, 3H), 6.83 (d, 1H), 6.70 (d, 1H), 6.34 ( d, 1H), 5.92 (dt, 1H), 4.91 (d, 1H), 3.87 (q, 2H), 3.30 (d d, 1H), 3.21 (t, 1H), 3.08 (s, 3H), 2.80 (d, 1H), 2.35 (dd , 1H), 2.10 (d, 1H), 2.03 (dd, 1H), 1.78 (dd, 1H), 1.46 (s , 3H), 1.44 (s, 3H), 1.11 (s, 3H), 0.88 (s, 3H)16-Sulfoxyphenyl-15,16-dehydro-17-ketomarcfortine A (formula 23) Synthesis   Crude 16-thiophenyl-15,16 in methylene chloride (300 mL) at -78 ° C -Dehydro-17-ketomarcfortine A (formula 22, 10.6 g) with CH₂Cl₂ Add m-CPBA (64%, 2.8 g) in (125 mL) dropwise. Saturate the reaction Quench with sodium thiosulfate (300 mL) and saturated sodium bicarbonate, Then extract into methylene chloride (300 mL). Dry the organic layer (MgSO_Four) , Filtered and concentrated to 13 g of crude 16-sulfoxyphenyl-15,16-dehydro -17-Ketomarcfortine A (formula 23) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) 7.75-7.3 (m, 5H), 6.81 (s, 1H ), 6.75-6.6 (m, 2H), 6.31 (d, 1H), 4.90 (d, 1H), 3.78-3.5 8 (m, 2H), 3.22 (t, 1H), 2.98 (s, 3H), 2.88-2.45 (m, 2H), 2.12-1.55 (m, 5H), 1.46 (s, 3H), 1.44 (s, 3H), 1.12 (s, 3 H), 0.88 (s, 3H) 16-Sulfoxyphenyl-15,16-dehydro-17-ketomarcfortine A (formula 23) 14α-hydroxy-15,16-dehydro-17-ketomarcfortine fromSynthesis of A (Formula 9a)   Crude 16-sulfoxyphenyl-1 in aqueous MeOH (10/1, 300 mL) 5,16-dehydro-17-ketomarcfortine A (formula 23, 13g), diethyl Add amine (15 mL). After refluxing for 0.5 hour, the reaction mixture was cooled to room temperature. Discard, dilute with water (450 mL), CH₂Cl₂Extract into (500 mL). Dry Dry (MgSO_Four), Followed by concentration and silica gel chromatography (130 g, 30% acetone / CH as eluent₂Cl₂), 14α-hydroxy-15, 16-dehydro-17-marcfortine A (formula 9a, 3.6g, 16-dithiophene 50% yield from le-17-ketomarkfortin A) as a white solid.Example 6.14 α-Hydroxy-N (1) -morpholinocarbonyl marcfortine Synthesis of A (Formula 25)   Potassium hydride (50% oil dispersion 70 mg) was added to 3 mL of dry tetrahydro. Add to a solution of 14α-hydroxymarcfortine A (30 mg) in furan . The solution was stirred at room temperature for 1 hour, then morpholinocarbonyl chloride (30 μL) Is added. The mixture was stirred at room temperature for 1 hour, then 5% aqueous sodium bicarbonate solution. Partition between liquid (3 mL) and methylene chloride (3 mL). Separate the layers, Aqueous layer Is extracted with methylene chloride (3 mL). Dry the combined extracts over magnesium sulfate. Dry, filter and evaporate under vacuum. Preparative layer for residue on silica gel plate Chromatography (eluted with 5% methanol in methylene chloride), 14α -Hydroxy-N (1) -morpholinocarbonyl marcfortine A (15 mg) obtain. Elemental analysis C₃₃H₄₂N_FourO₇+ H, HRMS (FAB) M / Z [M + H] Calculated: 607.3132; Found: 607.3153Example 7.14 Synthesis of α-acetoxymarcfortine A (Formula 26)   14α-Hydroxymarcfortine A (50 mg) was added to acetonitrile / methyl chloride. Dissolve in ren (4 mL / 2 mL). This solution was added to acetic anhydride (50 μL) Treat with ethylamine (50 μL) and 4-dimethylaminopyridine (20 mg). Make sense. The mixture is refluxed for 1 hour and cooled to room temperature. Stir it for 16 hours at room temperature. Stir, then 5% aqueous sodium bicarbonate (3 mL) and methylene chloride (3 m Distribute during L). Separate the layers and extract the aqueous layer with methylene chloride (3 mL). To do. The combined extracts were dried over magnesium sulfate, filtered, and then under vacuum. Evaporate. Preparative layer chromatography of the residue on a silica gel plate (chloride Eluted with 2.5% methanol in methylene) and added 14α-acetoxymarkol. Chin A (30 mg) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) 8.70 (s, NH), 6.80 (d, J = 8.1) Hz, C_Four-H), 6.68 (d, J = 8.1Hz, C_Five-H), 6.37 (d, J = 7.7 Hz, C_{twenty four}-H), 5.44 (t, J = 2.5Hz, C₁₄-H), 4.92 (d, J = 7.7Hz, C_{twenty five} -H), 3.75 (d, J = 11.8Hz, 1C₁₂-H), 3.12 (s, 3H, N-Me), 3. 04 (t, J = 10.2Hz, C₂₀-H), 2.6-2.8 (m, 2H), 2.5-2.1 (m, 3) H), 2.16 (s, 3H, O-acetyl), 2.0-1.5 (m, 4H), 1.44 (s, 6H, C₂₇ -H & C₂₈-H), 1.12 (s, 3H), 0.88 (s, 3H)Example 8.14 α-O-ethoxycarbonylaminocarbonylmarcfortine A ( Synthesis of formula 27)   14α-Hydroxymarcfortine A (33 mg) was added to acetonitrile / methyl chloride. Les Dissolve in water (2 mL / 1 mL). Add this solution to ethoxycarbonyl isocyanate. Solution (30 μL). The mixture is stirred at room temperature for 1 hour and then concentrated. Preparative layer chromatography of the residue on a silica gel plate (in methylene chloride Elution with 5% methanol), 14α-ethoxycarbonylaminocarbonyl Marcfortine A (25 mg) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) 8.80 (br, 1H, NH), 7.50 (s, N H), 6.80 (d, J = 8.1Hz, C_Four-H), 6.68 (d, J = 8.1Hz, C_Five-H), 6 .37 (d, J = 7.7Hz, C_{twenty four}-H), 5.42 (t, J = 2.5Hz, C₁₄-H), 4.9 2 (d, J = 7.7Hz, C_{twenty five}-H), 4.24 (q, 2H, J = 7.1Hz, O-CH₂), 3. 72 (d, J = 11.8Hz, 1C₁₂-H), 3.13 (s, 3H, N-Me), 3.08 (t, J = 10.2Hz, C₂₀-H), 2.6-2.8 (m, 2H), 2.5-2.1 (m, 5H), 2.0 -1.5 (m, 5H), 1.44 (s, 6H, C₂₇-H & C₂₈-H), 1.28 (t, 3H, J = 7 .1z, OCH₂-CH₃), 1.12 (s, 3H), 0.88 (s, 3H)Example 9.14 α-Hydroxy-N (1) -acetylmarcfortine A (Formula 28) Synthesis of   Potassium hydride (50% oil dispersion 70 mg) was added to 3 mL of dry tetrahydrofuran. Add to solution of 14α-hydroxymarcfortine A (40 mg) in orchid. The solution is stirred at room temperature for 1 hour, then acid anhydride (50 μL) is added. mixture The mixture was stirred at room temperature for 1 hour, then 5% aqueous sodium bicarbonate (3 mL) and Partition between methylene chloride (3 mL). Separate the layers and separate the aqueous layer with methyl chloride. Solution (3 mL). The combined extracts were dried over magnesium sulfate, filtered and , Evaporated under vacuum. Preparative layer chromatograph for residue on silica gel plate Phi (eluted with 5% methanol in methylene chloride), 14α-hydroxy- N (1) -acetylmarcfortine A (10 mg) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) δ 6.88 (q, J = 8.1Hz, C_Four-H & C_Five -H), 6.37 (d, J = 7.7Hz, C_{twenty four}-H), 4.09 (br, C₁₄-H), 4.86 (d, J = 7.7Hz, C_{twenty five}-H), 3.23 (d, J = 11.3Hz, 1C₁₂-H), 3.11 (s, 3H, N-Me), 3.0-1.5 (m, 12H), 2.61 (s, 3H, N-acetyl), 1 .44 & 1.46 (2s, 6H, C₂₇-H & C₂₈-H), 1.08 (s, 3H), 0.82 (s, 3H)Example 10.14 α-O- (10-Undecenoyl) Marcfortine A (Formula 29) Synthesis of   14α-Hydroxymarcfortine A (33 mg) was added to acetonitrile / methyl chloride. Dissolve in ren (4 mL / 2 mL). This solution was added to 10-undecenoyl chloride ( 40 μL), triethylamine (40 μL) and 4-dimethylaminopyridine Treat with (18 mg). The mixture is refluxed for 16 hours and cooled to room temperature. Then It was treated with 5% aqueous sodium bicarbonate (3 mL) and methylene chloride (3 mL). Distribute between. Separate the layers and extract the aqueous layer with methylene chloride (3 mL). The combined extracts are dried over magnesium sulphate, filtered and evaporated under vacuum. Preparative layer chromatography of the residue on a silica gel plate (in methylene chloride Elution with 5% methanol), 14α-O- (10-undecenoyl) markho Rutin A (7 mg) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) δ8.42 (s, NH), 6.80 (d, J = 8. 1Hz, C_Four-H), 6.68 (d, J = 8.1z, C_Five-H), 6.35 (d, J = 7.7 Hz, C_{twenty four}-H), 5.78 (m, 1H), 5.44 (br, C₁₄-H), 4.89-5.0 (m, 3H), 3.74 (d, J = 11.8Hz, 1C₁₂-H), 3.12 (s, 3H, N-Me), 3.05 ( t, J = 10.2Hz, C₂₀-H), 2.6-2.8 (m, 2H), 2.9-1.2 (m, 28H), 1.44 (s, 6H, C₂₇-H & C₂₈-H), 1.11 (s, 3H), 0.82 (s, 3H)Example 11.14 of α-hydroxy-14β-vinylmarcfortine A (Formula 30) Preparation   14-Ketomarcfortine A (200 mg, 0 in -78 ° THF (5 mL) Solution of vinylmagnesium bromide (1M, 4.0 mL, 4 mmol) solution. The resulting mixture is at -78 ° for 2 hours. Allow to stir and warm to room temperature. It is stirred at room temperature for 2 hours. 10% NaHCO₃ Quench the reaction by adding (3 mL). CH the mixture₂Cl₂ Dilute with (30 mL), wash with saturated ammonium chloride solution and dry (MgSO_Four) And concentrate. The residue was chromatographed on silica gel (6: 4 hexane: acetate). 14α-hydroxy-14β-vinylmarcfortine A (120 tons) mg, 60%, R_f= 0.45) as a white solid.¹ 1 H NMR (300 Hz, CDCl₃) δ 7.86 (s, NH), 6.78 & 6.67 (d, J = 8.1Hz, C_Four-H & C_Five-H), 6.32 (d, J = 7.7Hz, C_{twenty four}-H), 6.58 ( dd, J = 17.4,10.9Hz, 1H, vinyl), 5.43 (d, J = 17.4Hz, 1 H, vinyl), 5.18 (d, J = 10.9 Hz, 1H, vinyl), 4.89 (d, J = 7.7) Hz, C_{twenty five}-H), 3.7 (br, 1H), 3.11 (s, 3H, N-Me), 2.95 (t, 1H, C₂₀-H), 2.8-1.5 (m, 12H), 1.44 (s, 6H, C₂₇-H & C₂₈-H), 1.0 8 (s, 3H), 0.82 (s, 3H) MS (FAB) M / Z [M + H]: 520Example 12.14 α-O-morpholinocarbonyl-N (1) -morpholinocarbonyl Synthesis of Marcfortine A (Formula 31)   Potassium hydride (50% oil dispersion 50 mg) was added to 3 mL of dry tetrahydro. Add to a solution of 14α-hydroxymarcfortine A (25 mg) in furan . The solution was stirred at room temperature for 1 hour, then actic anhydride (30μ L) is added. The mixture was stirred at room temperature for 3 hours, then 5% sodium bicarbonate Partition between aqueous solution (3 mL) and methylene chloride (3 mL). Separated layers The aqueous layer is extracted with methylene chloride (3 mL). Combine the extracts with magnesium sulfate. Dry with sium, filter and evaporate under vacuum. Residue on silica gel plate Preparative layer chromatography (eluted with 5% methanol in methylene chloride) , 14α-O-morpholinocarbonyl-N (1) -morpholinocarbonyl marcufo Rutin A (17 mg) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) δ6.84 (q, J = 8.1Hz, C_Four-H & C_Five -H), 6.41 (d, J = 7.7z, C_{twenty four}-H), 3.8-3.2 (m, 17H), 2.98 (s, 3H, N-Me), 3.0-1.5 (m, 13H), 1.45 (s, 6H, C₂₇-H & C₂₈-H), 1.41 (s, 3H, C₁₄-Me), 1.18 (s, 3H), 0.83 (s, 3H) Example. 13:14 α-hydroxy-14β-methylmarcfortine A N-oxy Preparation of formula (Formula 32)   CH₂Cl₂Add a solution of 14α-hydroxymarcfortine A in (3 mL) to 0 ° Of m-chloroperoxybenzoic acid (20 mg). The mixture is stirred for 0.5 hours. After stirring, then add 5% aqueous sodium bicarbonate solution (10 mL) and methyl chloride. Partition (20 mL). The layers were separated and the aqueous layer was washed with methylene chloride (10 mL). The combined extracts were dried over magnesium sulfate, filtered, 0 ° Evaporated under vacuum, treated with triethylamine (30 μL), concentrated and The compound is produced as a solid (20 mg).¹ 1 H NMR (300 MHz, CD₃OD) δ 6.91 & 6.70 (d, J = 8.1 Hz, C_Four-H & C_Five-H), 6.36 (d, J = 7.7Hz, C_{twenty four}-H), 4.91 (d, J = 7.7) Hz, C_{twenty five}-H), 4.08 & 3.76 (AB q, J = 12.9Hz, 2H, C₁₂-H), 3.5 -3.1 (m, 4H), 3.12 (s, 3H, N-Me), 2.8-1.6 (m, 7H), 1.46 & 1.44 (2s, 6H, C₂₇-H & C₂₈-H), 1.50 (s, 3H, C₁₄-Me), 1.20 ( s, 3H), 0.93 (s, 3H)Example 14.14 α-Hydroxy-14β-methyl-N (1) -acetylmarkol Synthesis of Chin A (Formula 33)   Potassium hydride (50% oil dispersion 50 mg) was added to 3 mL of dry tetrahydro. Of 14α-hydroxy-14β-methylmarcfortine A (25mg) in furan Add to solution. The solution was stirred at room temperature for 1 hour and then actic Anhydrous (50 μL) is added. The mixture was stirred at room temperature for 1 hour, then 5% Partition between aqueous sodium bicarbonate (3 mL) and methylene chloride (3 mL). Let Separate the layers and extract the aqueous layer with methylene chloride (3 mL). Combined extraction The output is dried over magnesium sulphate, filtered and evaporated under vacuum. silica gel Preparative layer chromatography of the residue on the plate (5% methanol in methylene chloride). Elution) with 14α-hydroxy-14β-methyl-N (1) -acetylmer. Lucfortine A (20 mg) is obtained.¹ 1 H NMR (300 MHz, CDCl₃) δ 6.88 (q, J = 8.1Hz, C_Four-H & C_Five-H), 6.37 (d, J = 7.7Hz, C_{twenty four}-H), 4.86 (d, J = 7.7Hz, C_{twenty five}- H), 3.68 (d, 1C₁₂-H), 3.11 (s, 3H, N-Me), 2.9-2.7 (m, 2H), 2.61 (s, 3H, N-acetyl), 2.5-1.5 (m, 10H), 1.47 & 1.46 (2 s, 6H, C₂₇-H & C₂₈-H), 1.50 (s, 3H, C₁₄-Me), 1.08 (s, 3H) 0. 82 (s, 3H)Preparation of 14α-hydroxy-15α-methyl-17-ketomarcfortine A (Formula 34) Made   14α-Hydroxy-15,16-dehydro-17-ketomer in THF (12 mL) A solution of Lukfortine A (formula 9a, 300 mg) was added to room temperature methylmagnesium bromide. Solution (3M, 1.0 mL, 5 eq). 1.5 hours for the resulting mixture Reflux and then cool to room temperature. The reaction was charged with saturated ammonium chloride (3 mL) Quench by adding. CH the mixture₂Cl₂Diluted with (30 mL) , Washed with saturated ammonium chloride solution and dried (MgSO_Four) And concentrate. The residue, Subject to silica gel chromatography (eluting with 1:20 MeOH: methylene chloride). , 14α-hydroxy-15α-methylmarcfortine A (90mg, 30%) As a white solid.¹ 1 H NMR (300 MHz, CDCl₃) δ 7.90 (s, NH), 6.80 & 6.70 ( d, J = 8.1Hz, C_Four-H & C_Five-H), 6.32 (d, J = 7.7Hz, C_{twenty four}-H), 4.8 9 (d, J = 7.7Hz, C_{twenty five}-H), 4.36 (br, 1H, C₁₄-H), 3.74 (br, 2 H, C₁₂-H), 3.20 (t, 1H, C₂₀-H), 3.06 (s, 3H, N-Me), 2.78 & 2.10 (d, 2H, J = 15.8Hz, C_Ten-H), 2.5-1.8 (m, 5H), 1.46 & 1.44 (2s, 6H, C₂₇-H & C₂₈-H), 1.13 (d, 3H, C_Fifteen-Me), 1.12 ( s, 3H), 0.88 (s, 3H)   Alternatively, the title compound is the use of a lithium dimethylcopperate reagent. Therefore, it can be prepared. To copper iodide (0.4 g, 0.002 mol) in THF at 0 ° C. , Methyllithium (1.4 M, 9 mL, 0.013 mol) is added dropwise. Obtained light The yellow mixture was stirred for 15 minutes, then 14α-in THF (12 mL) at 0 ° C. Hydroxy-15,16-dehydro-17-ketomarcfortine A (Formula 9a, 0.5 g , 0.001 mol). After 15 minutes of stirring, saturate the thick orange mixture. Ammo chloride Quench with Ni (25 mL) and extract with EtOAc (30 mL). Orange extraction Dried (MgSO_Four), Filtered and concentrated to give the crude material which is (4mm plate, 4% MeOH / CH₂Cl₂) Purified the product (0.23 g) , 44%) as a white solid.Example 15.14 of α-Hydroxy-15α-methylmarcfortine A (Formula 35) Preparation   14α-hydroxy-15α-methyl-17-ketomarcfortine A (90 mg, 0.18 mmol) was dissolved in THF (10 mL) and the borane dimethylsulfate at 0 ° was added. Treat with fido complex (12M, 0.18 mL). Stir the mixture at 0 ° for 2 hours And then add MeOH (0.4 mL) and stir an additional 1 h. Steam solvent After evaporation, the residue was chromatographed on silica gel (acetone: salt 30:70). Methylene chloride), and 14α-hydroxy-15α-methylmarcfortine A (2 0 mg) as a solid.¹ 1 H NMR (300 MHz, CDCl₃) δ 8.39 (s, NH), 6.79 & 6.70 (d , J = 8.1Hz, C_Four-H & C_Five-H), 6.36 (d, J = 7.7Hz, C_{twenty four}-H), 4.91 (d, J = 7.7Hz, C_{twenty five}-H), 3.81 (br, 1H, C₁₄-H), 3.67 (d, 1H, J = 11.7 Hz, C₁₂-H), 3.03 (t, 1H, C₂₀-H), 3.11 (s, 3H, N-Me) , 2.68 & 1.86 (d, 2H, J = 15.7Hz, C_Ten-H), 2.7-1.2 (m, 8H), 1.44 (2s, 6H, C₂₇-H & C₂₈-H), 1.02 (d, 3H, J = 6.8Hz, C_Fifteen- Me), 1.11 (s, 3H), 0.85 (s, 3H) Elemental analysis C₂₉H₃₇N₃O_Five+ H, HRMS (FAB) M / Z [M + H] Calculated: 508.2811; Found: 508.2840Preparation of 14,17-Diketo-15α-methylmarcfortine A (Formula 36)   Anhydrous CH₂Cl₂Add a solution of oxalyl chloride (40 μL) in (5 mL) to -78 ° DMSO (45 μL). The mixture is stirred at -78 ° for 1 hour. C H₂Cl₂14α-hydroxy-15α-methyl-17-ketomarkol in (2 mL) A solution of Chin A (27 mg) is added dropwise. Stir reaction mixture at -78 ° for 20 minutes To do. Triethylamine (0.3 mL) was added to the reaction mixture which was added for 20 minutes. Warm to room temperature Meru. Mix the mixture with 10% Na₂CO₃(10 mL) and CH₂Cl₂(10 mL) Distribute between. Dry the organic layer (MgSO_Four) And concentrate. The residue is treated with silica gel. Chromatography (1:20 MeOH: CH₂Cl₂), 14,17- Diketomarcfortine A (22 mg, 80%) is obtained as a white solid. Product The structure of can be confirmed by NMR spectrum and mass spectrometry. Elemental analysis C₂₈H₃₁N₃O₆+ H, HRMS (FAB) M / Z [M + H] Calculated: 506.2291; Found: 506.228014α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine A Preparation of (Formula 37)   -78 ° CH₂Cl₂14,17-Diketo-15α-methylmarkho in 5 mL A solution of rutin A (25 mg, 0.05 mmol) was added at -78 ° Et.₂Bromide in O Treat with a solution of tilmagnesium (3M, 0.2 mL, 0.6 mmol). Got The resulting mixture is stirred at -78 ° for 0.5 hours. 10% Na₂CO₃Add (a few drops) The reaction is quenched by addition. CH the mixture₂Cl₂(10 mL) Dilute and dry (MgSO_Four) And concentrate. The residue is chromatographed on silica gel. -(1:25 MeOH: CH₂Cl₂) Attached to 14α-hydroxy-14β-meth Le-15α-methyl-17-ketomarcfortine A (16 mg, 62%) as a white solid Get as a thing.¹ 1 H NMR (300 MHz, CDCl₃) δ 8.13 (s, 1H), 6.78 (d, 1H), 6 .70 (d, 1H), 6.33 (d, 1H), 4.91 (d, 1H), 3.75 (q, 2H), 3.1 6 (t, 1H), 3.05 (s, 3H), 2.78 (d, 1H), 2.68-2.57 (m, 1H), 2.42-2.0 (m, 6H), 1.64 (s, 3H), 1.45 (s, 3H), 1.44 (s, 3H ), 1.11 (s, 3H), 1.04 (d, 3H), 0.92 (d, 3H)Example 16. 14α-Hydroxy-14β-methyl-15α-methylmarcfortine Preparation of A (Formula 38)   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine A (15 mg, 0.028 mmol) was dissolved in THF (10 mL) and the solution was added to a 0 ° solution. Treat with landimethyl sulfide complex (10 M, 0.02 mL). Mixture 0 Stir at 0 ° C for 2 hours, then add MeOH (0.4 mL) and stir for another 1 hour. Stir. Melting After evaporation of the medium, the residue is chromatographed on silica gel (acetate 30; 70). Ton: methylene chloride), 14α-hydroxy-14β-methyl-15α-methyl Lumarcfortine A (4 mg, 29%) is obtained as a solid.¹ 1 H NMR (300 MHz, CDCl₃) δ 7.82 (s, 1H), 6.79 (d, 1H), 6 .67 (d, 1H), 6.33 (d, 1H), 4.90 (d, 1H), 3.65 (d, 1H), 3.0 9 (s, 3H), 2.98 (t, 1H), 2.69 (d, 1H), 2.60-2.22 (m, 7H), 2.06 (dd, 1H), 1.87 (d, 1H), 1.85-1.75 (m, 1H), 1.44 (s, 6H), 1.43 (s, 3H), 1.10 (s, 3H), 0.94 (d, 3H), 0.86 (s, 3H )   Suitable C-24, C-25, N-1 and starting materials for the starting materials in the above series of reactions And N-18a substituted marcfortine A, B, C and D derivatives are described in US Pat. It can be easily prepared by the method described in No. 23,867. Reaction is 10 Pyridine, collidine, (preferably at a temperature of ° to 180 °, preferably 80 to 140 °) Suitable is toluene, xylene, dioxane, tetrahydrofuran, etc. Perform in the appropriate inert solvent.   Alternatively, the C-24, C-25 and N-1 derivatives are prepared from marcfortine. It can also be manufactured. For example, the vast series of Marcfortine analogs are It can be prepared by alkylation of N-1 of -18a substituted marcfortine. these Derivatives have aprotic properties such as tetrahydrofuran, ether, benzene, etc. Marcfortine A, N-18a-substituted Marcfortine B or N-18 in organic solvent a-substituted marcfortine C is (preferably) potassium hydride, sodium hydride Butyl lithium, potassium tert-butoxide, etc. And a suitable alkylating agent at 0 ° C to 50 ° C for 0.25 to 48 hours. It can be easily prepared. Suitable alkylating agents include alkyl bromide, io Alkyl bromide, alkyl sulfonate, alkenyl iodide, alkynyl bromide, chloride Alkoxyalkyl and the like are included.   A further series of derivatives is C25-C2 of marcfortine A, B and C. It can be generated by modification of 5 double bonds. 24,25-dihydroanaroc is Alcohol such as methanol, ethanol, propanol in the presence of hydrogen gas A solution of the appropriate marcfortine in a polar solvent is added to palladium, platinum, tris (trif (Phenylphosphine) -chlorophodium, etc. It can be easily prepared. Product, ie 24,25-dihydromarcfortine analogue Can be separated and purified by using techniques known to those skilled in the art. Marcho For the modification of other parts of the rutin structure, the above reaction was also carried out using 24,25-dihydromark. Can be applied to fortin analogs to prepare corresponding 24,25-dihydro analogs It should be noted that. Additional G-ring modified analogs of marcfortine are Markho in halogenated solvents such as loromethane, chloroform, carbon tetrachloride, etc. A solution of rutin is added with 1 molar equivalent of bromine at a temperature range of -20 to 25 ° C. Can be prepared via 24,25-bromide which can be easily prepared by treating for 8 hours Wear. This process allows the corresponding 24,25-dibromo 24,25-dihydromer A lucfortine derivative is obtained, which uses techniques known to those skilled in the art. Can be isolated and purified by. The 24,25-dichloro analog was added to the process described above. It should be noted that it can be prepared by replacing bromine with chlorine in . The 24,25-dibromo-24,25-dihydro-marcfortine analog described above is , A useful intermediate for the preparation of further derivatives. Thus, methanol, ethanol A solution of the dibromide in an alcoholic solvent such as knoll, propanol, etc. With a strong base such as 8,8-diazabicyclo [5.4.0] undec-7-ene (DBU) When treated at a temperature range of 0 ° C to 30 ° C for 0.25 to 24 hours, 24-alkoxy- A 25-bromo-24,25-dihydro-marcfortine analog is obtained, which is It can be isolated and purified by using a technique known to those skilled in the art. These 24-al Coxy and 25-bromo derivatives are like azobis-isobutyronitrile (AIBN). When adding or not adding a starting radical agent, benzene, toluene, hexane, etc. A solution of the compound in an aprotic organic solvent such as tributyltin hydride, hydrogen A tin hydride reducing agent such as triphenyl tin halide at 25 ° C to 120 ° C. Debromination can be performed by treating for 5 to 48 hours. This process helps 24-alkoxy-marcfortine derivative (R_{twenty four}= Lower Alkoki of the general formula Is obtained and is isolated and purified by using techniques known to those skilled in the art. it can.   Haemonchus contortus / Trico Stonilla Trichostrongylus colubriformis / Jird Essay:   This in vivo assay uses two important target parasites in ruminants, h. H.contortus and T.colubriformis ) Infected jird (for anthelmintic drug-sensitive or -resistant helminths) Can be). G.A.Conder et al., Journal of B. Parasitol., Vol. 76, pp. 168-170 (1990). First, only active against H. contortus, as described in However, in the supplementary examination, G.A.Conder et al., Journal ・ J. Parasitol., 77, 621-623 (19) Test activity against parasites of both species using techniques outlined in (1991). It 14α-Hydroxymarcfortine A, 14α-hydroxy-14β-methylmark Hortin A, 14β-Hydroxymarc Hortin A, 14α-Hydroxymarkho The activities of rutin A N-oxide and marcfortine D are listed in Table I.

─────────────────────────────────────────────────── ─── Continued front page    (81) Designated countries EP (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, M C, NL, PT, SE), OA (BF, BJ, CF, CG , CI, CM, GA, GN, ML, MR, NE, SN, TD, TG), AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, G B, GE, HU, JP, KG, KP, KR, KZ, LK , LU, LV, MD, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SI, S K, TJ, TT, UA, US, UZ, VN

Claims (1)

[Claims] 1. Formula I: [In the formula,   m is 0 or 1;   Z is O or S;   Y is an oxygen atom (-O-) or a bond;   R₁Is hydrogen, C₁-C₇Alkyl, cyclo C₃-C₈Alkyl, benzyl, {desirably More, carboxy (-COOH), C₁-C₇Alkanoyl, carbo C₁-C₇Arco Xy (-C (O) OC₁-C₇Alkyl), -NR_FourR_Five, Aminocarbonyl (-C (O) N R_FourR_Five) May be substituted with} C₂-C₇Alkanoyl (-C (O) C₂-C₇Al Kill), C_Ten-C_{twenty four}Alkanoyl (-C (O)) C_Ten-C_{twenty four}Alkyl), {if desired R, carboxy, C₁-C₇Alkanoyl, carbo C₁-C₇Alkoxy, -NR_FourR_Five , Optionally substituted with aminocarbonyl} cycloC₃-C₈Alkanoyl, a Lucanoyloxymethylene (-CH₂OC (O) -C₂-C₇Alkyl), {if desired , Halogen, C₁-C_FourAlkyl, halo C₁-C₇Alkyl, nitro, cyano and C₁ -C₇Optionally substituted with 1 or 2 groups selected from alkoxy} Nzoyloxymethylene (-CH₂OC (O) phenyl), C_Ten-C_{twenty four}Alkenoyl (-C (O) C₉-C_{twenty three}Alkenyl), {optionally halogen, C₁-C_FourAlkyl, Halo C₁-C₇Alkyl, nitro, cyano and C₁-C₇Selected from alkoxy 1 or 2 groups may be substituted} benzenesulfonyl (-SO₂CH₂ Phenyl), C₁-C_FourAl Killaminocarbonyl (-C (O) N (C₁-C_FourAlkyl)₂), C₁-C_FourAlkylami Nothiocarbonyl (-C (S) N (C₁-C_FourAlkyl)₂), C₁-C₇Alkoxy carbo Nil, {optionally halogen, C₁-C_FourAlkyl, halo C₁-C₇Alkyl, nit B, cyano and C₁-C₇Substituted with 1 or 2 groups selected from alkoxy May be present} phenoxycarbonyl, -C (O) NR '_FourR '_Five, -P (= X) (R₂) ( R₃),-SR₆, -SO₂NR_FourR_Five3rd or 4th place is -CH₂NR_FourR_FiveReplaced by Benzoyl or bicyclo C₈-C₁₂Alkanoyl;   R_FourAnd R_FiveAre the same or different and are hydrogen, C₁-C₇Alkyl, {if desired , Halogen, C_1-4Alkyl, halo C₁-C₇Alkyl, nitro, cyano and C₁- C₇Optionally substituted with 1 or 2 groups selected from alkoxy} When combined with Nil or N, forms a saturated or unsaturated heteroamine ring Do;   R '_FourAnd R '_FiveAre the same or different, and C₁-C₇Alkyl, cyclo (C₃-C₈) Alkyl, {optionally halogen, C_1-4Alkyl, halo C₁-C₇Alkyl, d Toro, Cyano and C₁-C₇Substituted with 1 or 2 groups selected from alkoxy Optionally combined with phenyl, or when combined with N, optionally with N , 1 or 2 further heteroatoms selected from O or S Form a good saturated heteroamine ring;   X is O or S;   R₂And R₃Are the same or different, and C₁-C₇Alkyl, {optionally halo Gen, C_1-4Alkyl, halo C₁-C₇Alkyl, nitro, cyano and C₁-C₇A Optionally substituted with 1 or 2 groups selected from lucoxy} phenyl, C₁-C₇Alkoxy, thio (C₁-C₇) Alkoxy, phenoxy, thiophenoxy , -NR₇R₈{Niko ni, R₇And R₈Are the same or different and are H, C₁-C₇Archi Selected from the formulas, or together with N, forms a saturated heterocycle} Or together with P to form a 4- to 7-membered heterocycle;   R₆Is C₁-C₇Alkyl, halo C₁-C₇Alkyl, carbo C₁-C₇Alkoxy,- NR₉R_TenThen R here₉And R_TenAre the same or different, and C₁-C₇Alkyl Or (optionally halogen, lower alkyl, halo C₁-C₇Alkyl, nitro, Cyano, C₁-C₇Substituted by 1 or 2 groups selected from alkoxy Good) phenyl;   R_{twenty four}Is hydrogen, halogen or C₁-C₇Alkoxy;   R_{twenty five}Is hydrogen or halogen;   R_18aIs hydrogen, C₁-C₇Alkyl, C₂-C₈Alkoxyalkyl, C₂-C₈Arche Nil, C₂-C₈Alkynyl or benzyl;   R_14aIs hydroxyl, hydrogen, C₁-C₇Alkyl, C₂-C₈Alkoxy alkyl , Cyclo (C₃-C₈) Alkyl or (optionally halogen, lower alkyl, Halo C₁-C₇Alkyl, nitro, cyano, C₁-C₇1 selected from alkoxy Or optionally substituted with two groups) benzyl;   R_14bIs hydroxyl, hydrogen, C₁-C₇Alkoxy, cyclo (C₃-C₈) Archi Or (optionally halogen, lower alkyl, halo C₁-C₇Alkyl, d Toro, cyano, C₁-C₇Substituted with 1 or 2 groups selected from alkoxy Benzoxyl;   R_15aAnd R_15bAre both hydrogen, but R_14aOr R_14bOne of them is hydro R, when xyl is the other hydrogen or methyl_15aAnd R_15bIs hydrogen Or may be methyl; the dashed line between carbons 24 and 25 is a single bond or double Indicates a bond; provided that R as a whole_14aAnd R_14bDo not become hydrogen together] Or a pharmaceutically acceptable salt or 12α-N-oxide thereof. 2. The compound according to claim 1, wherein m is 0. 3. R_{twenty four}And R_{twenty five}Is hydrogen; R_18aIs hydrogen, C₁-C₇Alkyl, C₁-C₈Arcoki Cimethyl, C₂-C₈Alkenyl or benzyl; Y is -O-; dashed line is carbon The compound of claim 2 which exhibits a double bond between 24 and 25. 4. The compound according to claim 1, wherein Z is an oxygen atom. 5. R_{twenty four}And R_{twenty five}Is hydrogen; R_18aIs hydrogen, C₁-C₇Alkyl, C₁-C₈Arcoki Cimethyl, C₂-C₈Alkenyl or benzyl; Y is -O-; dashed line is carbon A compound according to claim 4 which exhibits a double bond between 24 and 25. 6. The compound according to claim 1, wherein Z is a sulfur atom. 7. R_{twenty four}And R_{twenty five}Is hydrogen; R_18aIs hydrogen, C₁-C₇Alkyl, C₁-C₈Arcoki Cimethyl, C₂-C₈Alkenyl or benzyl; Y is -O-; dashed line is carbon A compound according to claim 5 which exhibits a double bond between 24 and 25. 8. 1-acetoxymethyl-14α-hydroxymarcfortine A;   1-diethoxyphosphoryl-14α-hydroxymarcfortine A;   1-dimethylsulfamoyl-14α-hydroxymarcfortine A;   1-cyclopropylcarbonyl-14α-hydroxymarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxymarcfortine A ;   1- (1-Piperidinyl) thiocarbonyl-14α-hydroxymarcfortine A ;   1-succinoyl-14α-hydroxymarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxymarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxymarkol Chin A;   24-propoxy-24,25-dihydro-14α-hydroxymarcfortine A;   1- (p-toluenesulfonyl) -14α-hydroxymarcfortine A;   1-acetyl-14α-hydroxymarcfortine A;   1-methyl-14α-hydroxymarcfortine A;   1-benzyl-14α-hydroxymarcfortine A;   1-dimethylcarbamoyl-14α-hydroxymarcfortine A;   1-methoxycarbonyl-14α-hydroxymarcfortine A;   14α-hydroxymarcfortine B;   24,25-dihydro-14α-hydroxymarcfortine B;   24-methoxy-24,25-dihydro-14α-hydroxymarcfortine B;   1- (p-toluenesulfonyl) -14α-hydroxymarcfortine B;   1-ethyl-14α-hydroxymarcfortine B;   1-benzyl-14α-hydroxymarcfortine B;   18a-ethyl-14α-hydroxymarcfortine B;   18a-benzyl-14α-hydroxymarcfortine B;   18a-methoxyethoxymethyl-14α-hydroxymarcfortine B;   18a-allyl-14α-hydroxymarcfortine B;   18a-propargyl-14α-hydroxymarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxymark Hortin B;   1,18a-bis-ethyl-14α-hydroxymarcfortine B;   1,18a-bis-benzyl-14α-hydroxymarcfortine B;   18a-ethyl-24-methoxy-14α-hydroxymarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-ethyl-24,25-dihydro-14α-hydroxymarcfortine B;   24,25-dihydro-14α-hydroxymarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-hydroxymarcfortine C;   1-propionyl-14α-hydroxymarcfortine C;   1-propyl-14α-hydroxymarcfortine C;   1-benzyl-14α-hydroxymarcfortine C;   18a-propyl-14α-hydroxymarcfortine C;   18a-benzyl-14α-hydroxymarcfortine C;   18a-methoxyethoxymethyl-14α-hydroxymarcfortine C;   18-allyl-14α-hydroxymarcfortine C;   18a-propargyl-14α-hydroxymarcfortine C;   1,18a-bis-propyl-14α-hydroxymarcfortine C;   1,18a-bis-benzyl-14α-hydroxymarcfortine C;   14α-hydroxymarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxymarcfortine A;   1-palmitoyl-14α-hydroxymarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxymarcfortine A;   1-palmitoyl-14α-hydroxymarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxymarcfortine D;   14α-hydroxymarcfortine D;   1-acetoxymethyl-14α-hydroxymarcfortine D;   1-diethoxyphosphoryl-14α-hydroxymarcfortine D;   1-dimethylsulfamoyl-14α-hydroxymarcfortine D;   1-cyclopropylcarbonyl-14α-hydroxymarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxymarcfortine D ;   1- (1-Piperidinyl) thiocarbonyl-14α-hydroxymarcfortine D ;   1-succinoyl-14α-hydroxymarcfortine D;   1- (4-morpholinosulfenyl) -14α-hydroxymarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxymarkol Chin D;   24-propoxy-24,25-dihydro-14α-hydroxymarcfortine D;   1- (p-toluenesulfonyl) -14α-hydroxymarcfortine D;   1-acetyl-14α-hydroxymarcfortine D;   1-methyl-14α-hydroxymarcfortine D;   1-benzyl-14α-hydroxymarcfortine D;   1-dimethylcarbamoyl-14α-hydroxymarcfortine D;   1-methoxycarbonyl-14α-hydroxymarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methylmarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methylmarcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methylmarkholch A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methylmarkol Chin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methylmer Lukhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methylmer Lukhortin A;   1-succinoyl-14α-hydroxy-14β-methylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tilmarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methylmarkol Chin A;   1-acetyl-14α-hydroxy-14β-methylmarcfortine A;   1-methyl-14α-hydroxy-14β-methylmarcfortine A;   1-benzyl-14α-hydroxy-14β-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methylmarcfortine A;   1-Methoxycarbonyl-14α-hydroxy-14β-methylmarcfortine A ;   14α-hydroxy-14β-methylmarcfortine B;   24,25-dihydro-14α-hydroxy-14β-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methylmarkol Chin B;   1-ethyl-14α-hydroxy-14β-methylmarcfortine B;   1-benzyl-14α-hydroxy-14β-methylmarcfortine B;   18a-ethyl-14α-hydroxy-14β-methylmarcfortine B;   18a-benzyl-14α-hydroxy-14β-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methylmarkho Rutin B;   18a-allyl-14α-hydroxy-14β-methylmarcfortine B;   18a-propargyl-14α-hydroxy-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methylmarcfortine B;   1,18a-Bis-ethyl-14α-hydroxy-14β-methylmarcfortine B ;   1,18a-bis-benzyl-14α-hydroxy-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methylmarkol Chin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxy-14β-methylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methylmark Hortin B;   24,25-dihydro-14α-hydroxy-14β-methylmarcfortine C;   1- (p-Bromobenzenesulfonyl) -14α-hydroxy-14β-methylmar Kuhortin C;   1-propionyl-14α-hydroxy-14β-methylmarcfortine C;   1-propyl-14α-hydroxy-14β-methylmarcfortine C;   1-benzyl-14α-hydroxy-14β-methylmarcfortine C;   18a-propyl-14α-hydroxy-14β-methylmarcfortine C;   18a-benzyl-14α-hydroxy-14β-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methylmarkho Rutin C;   18-allyl-14α-hydroxy-14β-methylmarcfortine C;   18a-propargyl-14α-hydroxy-14β-methylmarcfortine C;   1,18a-Bis-propyl-14α-hydroxy-14β-methylmarcfortine C;   1,18a-bis-benzyl-14α-hydroxy-14β-methylmarcfortine C;   14α-hydroxy-14β-methylmarcfortine C;   1-palmitoyl-14α-hydroxy-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methylmarkho Rutin A;   1-palmitoyl-14α-hydroxy-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methylmarkho Rutin D;   14α-hydroxy-14β-methylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methylmarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methylmarkholch D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methylmarkol Chin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methylmer Lukhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methylmer Lukhortin D;   1-succinoyl-14α-hydroxy-14β-methylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tilmarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methylmarkol Chin D;   1-acetyl-14α-hydroxy-14β-methylmarcfortine D;   1-methyl-14α-hydroxy-14β-methylmarcfortine D;   1-benzyl-14α-hydroxy-14β-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-hydroxy-14β-ethylmarcfortine D;   1-methoxycarbonyl-14α-hydroxy-14β-ethylmarcfortine D ;   1-acetoxymethyl-14α-hydroxy-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-14β-ethylmarcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-ethylmarkholch A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-ethylmarkol Chin A:   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-ethylmer Lukhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-ethylmer Lukhortin A;   1-succinoyl-14α-hydroxy-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-ethylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-E Tilmarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-ethylmal Kuhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-ethylmarkol Chin A;   1-acetyl-14α-hydroxy-14β-ethylmarcfortine A;   1-methyl-14α-hydroxy-14β-ethylmarcfortine A;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-ethylmarcfortine A;   1-Methoxycarbonyl-14α-hydroxy-14β-ethylmarcfortine A ;   14α-hydroxy-14β-ethylmarcfortine B;   24,25-dihydro-14α-hydroxy-14β-ethylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-ethylmark Hortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-ethylmarkol Chin B;   1-ethyl-14α-hydroxy-14β-ethylmarcfortine B;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-ethyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-benzyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-ethylmarkho Rutin B;   18a-allyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-propargyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-ethylmarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-ethylmarcfortine B ;   1,18a-bis-benzyl-14α-hydroxy-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-ethylmarkol Chin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxy-14β-ethylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-ethylmark Hortin B;   24,25-dihydro-14α-hydroxy-14β-ethylmarcfortine C;   1- (p-Bromobenzenesulfonyl) -14α-hydroxy-14β-ethylmal Kuhortin C;   1-propionyl-14α-hydroxy-14β-ethylmarcfortine C;   1-propyl-14α-hydroxy-14β-ethylmarcfortine C;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-propyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-benzyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-ethylmarkho Rutin C;   18-allyl-14α-hydroxy-14β-ethylmarcfortine C;   18a-propargyl-14α-hydroxy-14β-ethylmarcfortine C;   1,18a-bis-propyl-14α-hydroxy-14β-ethylmarcfortine C;   1,18a-bis-benzyl-14α-hydroxy-14β-ethylmarcfortine C;   14α-hydroxy-14β-ethylmarcfortine C;   1-palmitoyl-14α-hydroxy-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-ethylmarkho Rutin A;   1-palmitoyl-14α-hydroxy-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-ethylmarkho Rutin D;   14α-hydroxy-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-14β-ethylmarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-ethylmarkholch D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-ethylmarkol Chin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-ethylmer Lukhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-ethylmer Lukhortin D;   1-succinoyl-14α-hydroxy-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-ethylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-E Tilmarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-ethylmal Kuhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-ethylmarkol Chin D;   1-acetyl-14α-hydroxy-14β-ethylmarcfortine D;   1-methyl-14α-hydroxy-14β-ethylmarcfortine D;   1-benzyl-14α-hydroxy-14β-ethylmarcfortine D;   1-acetoxymethyl-14β-methylmarcfortine A;   1-diethoxyphosphoryl-14β-methylmarcfortine A;   1-dimethylsulfamoyl-14β-methylmarcfortine A;   1-cyclopropylcarbonyl-14β-methylmarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14β-methylmarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14β-methylmarcfortine A;   1-succinoyl-14β-methylmarcfortine A;   1- (4-morpholinosulfenyl) -14β-methylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14β-methylmarcfortine A;   24-propoxy-24,25-dihydro-14β-methylmarcfortine A;   1- (p-toluenesulfonyl) -14β-methylmarcfortine A;   1-acetyl-14β-methylmarcfortine A:   1-methyl-14β-methylmarcfortine A;   1-benzyl-14β-methylmarcfortine A;   1-dimethylcarbamoyl-14β-methylmarcfortine A;   1-methoxycarbonyl-14β-methylmarcfortine A;   14β-methylmarcfortine B;   24,25-dihydro-14β-methylmarcfortine B;   24-methoxy-24,25-dihydro-14β-methylmarcfortine B;   1- (p-toluenesulfonyl) -14β-methylmarcfortine B;   1-ethyl-14β-methylmarcfortine B;   1-benzyl-14β-methylmarcfortine B;   18a-ethyl-14β-methylmarcfortine B;   18a-benzyl-14β-methylmarcfortine B;   18a-methoxyethoxymethyl-14β-methylmarcfortine B;   18a-allyl-14β-methylmarcfortine B;   18a-propargyl-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14β-methylmarkol Chin B;   1,18a-bis-ethyl-14β-methylmarcfortine B;   1,18a-bis-benzyl-14β-methylmarcfortine B;   18a-ethyl-24-methoxy-14β-methylmarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14β-methylmarcfortine B;   18a-ethyl-24,25-dihydro-14β-methylmarcfortine B;   24,25-dihydro-14β-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14β-methylmarcfortine C;   1-propionyl-14β-methylmarcfortine C;   1-propyl-14β-methylmarcfortine C;   1-benzyl-14β-methylmarcfortine C;   18a-propyl-14β-methylmarcfortine C;   18a-benzyl-14β-methylmarcfortine C;   18a-methoxyethoxymethyl-14β-methylmarcfortine C;   18-allyl-14β-methylmarcfortine C;   18a-propargyl-14β-methylmarcfortine C;   1,18a-bis-propyl-14β-methylmarcfortine C;   1,18a-bis-benzyl-14β-methylmarcfortine C;   14β-methylmarcfortine C;   1-palmitoyl-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14β-methylmarcfortine A;   1-palmitoyl-14β-methylmarcfortine D;   1- (4-morphoninocarbonyl) -14β-methylmarcfortine D;   14β-methylmarcfortine D;   1-acetoxymethyl-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14β-methylmarcfortine D;   1-dimethylsulfamoyl-14β-methylmarcfortine D;   1-cyclopropylcarbonyl-14β-methylmarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14β-methylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14β-methylmarcfortine D;   1-succinoyl-14β-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14β-methylmarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14β-methylmarcfortine D;   24-propoxy-24,25-dihydro-14β-methylmarcfortine D;   1- (p-toluenesulfonyl) -14β-methylmarcfortine D;   1-acetyl-14β-methylmarcfortine D;   1-methyl-14β-methylmarcfortine D;   1-benzyl-14β-methylmarcfortine D;   1-dimethylcarbamoyl-14β-methylmarcfortine D;   1-methoxycarbonyl-14β-methylmarcfortine D;   1-acetoxymethyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14β-ethylmarcfortine A;   1-dimethylsulfamoyl-14β-ethylmarcfortine A;   1-cyclopropylcarbonyl-14β-ethylmarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14β-ethylmarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14β-ethylmarcfortine A;   1-succinoyl-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14β-ethylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14β-ethylmarcfortine A;   24-propoxy-24,25-dihydro-14β-ethylmarcfortine A;   1- (p-toluenesulfonyl) -14β-ethylmarcfortine A;   1-acetyl-14β-ethylmarcfortine A;   1-methyl-14β-ethylmarcfortine A;   1-benzyl-14β-ethylmarcfortine A;   1-dimethylcarbamoyl-14β-ethylmarcfortine A;   1-methoxycarbonyl-14β-ethylmarcfortine A;   14β-ethylmarcfortine B;   24,25-dihydro-14β-ethylmarcfortine B;   24-methoxy-24,25-dihydro-14β-ethylmarcfortine B;   1- (p-toluenesulfonyl) -14β-ethylmarcfortine B;   1-ethyl-14β-ethylmarcfortine B;   1-benzyl-14β-ethylmarcfortine B;   18a-ethyl-14β-ethylmarcfortine B;   18a-benzyl-14β-ethylmarcfortine B;   18a-methoxyethoxymethyl-14β-ethylmarcfortine B;   18a-allyl-14β-ethylmarcfortine B;   18a-propargyl-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14β-ethylmarkol Chin B;   1,18a-bis-ethyl-14β-ethylmarcfortine B;   1,18a-bis-benzyl-14β-ethylmarcfortine B;   18a-ethyl-24-methoxy-14β-ethylmarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14β-ethylmarcfortine B;   18a-ethyl-24,25-dihydro-14β-ethylmarcfortine B;   24,25-dihydro-14β-ethylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14β-ethylmarcfortine C;   1-propionyl-14β-ethylmarcfortine C;   1-propyl-14β-ethylmarcfortine C;   1-benzyl-14β-ethylmarcfortine C;   18a-propyl-14β-ethylmarcfortine C;   18a-benzyl-14β-ethylmarcfortine C;   18a-methoxyethoxymethyl-14β-ethylmarcfortine C;   18-allyl-14β-ethylmarcfortine C;   18a-propargyl-14β-ethylmarcfortine C;   1,18a-bis-propyl-14β-ethylmarcfortine C;   1,18a-bis-benzyl-14β-ethylmarcfortine C;   14β-ethylmarcfortine C;   1-palmitoyl-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14β-ethylmarcfortine A;   1-palmitoyl-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14β-ethylmarcfortine D;   14β-ethylmarcfortine D;   1-acetoxymethyl-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14β-ethylmarcfortine D;   1-dimethylsulfamoyl-14β-ethylmarcfortine D;   1-cyclopropylcarbonyl-14β-ethylmarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14β-ethylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14β-ethylmarcfortine D;   1-succinoyl-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14β-ethylmarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14β-ethylmarcfortine D;   24-propoxy-24,25-dihydro-14β-ethylmarcfortine D;   1- (p-toluenesulfonyl) -14β-ethylmarcfortine D;   1-acetyl-14β-ethylmarcfortine D;   1-methyl-14β-ethylmarcfortine D;   1-benzyl-14β-ethylmarcfortine D;   1-dimethylcarbamoyl-14β-ethylmarcfortine D;   1-methoxycarbonyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-methylmarcfortine A;   14α-O-methylmarcfortine A;   14α-O-methyl-14β-methylmarcfortine A;   14α-O-methyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-O-methylmarcfortine A;   1-dimethylsulfamoyl-14α-O-methylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-methylmarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-methylmarcfortine A;   1- (1-Piperidinyl) thiocarbonyl-14α-O-methylmarcfortine A ;   1-succinoyl-14α-O-methylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-O-methylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methylmarkholch A;   24-propoxy-24,25-dihydro-14α-O-methylmarcfortine A;   1- (p-toluenesulfonyl) -14α-O-methylmarcfortine A;   1-acetyl-14α-O-methylmarcfortine A;   1-methyl-14α-O-methylmarcfortine A;   1-benzyl-14α-O-methylmarcfortine A;   1-dimethylcarbamoyl-14α-O-methylmarcfortine A;   1-methoxycarbonyl-14α-O-methylmarcfortine A;   14α-O-methylmarcfortine B;   24,25-dihydro-14α-O-methylmarcfortine B;   24-methoxy-24,25-dihydro-14α-O-methylmarcfortine B;   1- (p-toluenesulfonyl) -14α-O-methylmarcfortine B;   1-ethyl-14α-O-methylmarcfortine B;   1-benzyl-14α-O-methylmarcfortine B;   18a-ethyl-14α-O-methylmarcfortine B;   18a-benzyl-14α-O-methylmarcfortine B;   18a-methoxyethoxymethyl-14α-O-methylmarcfortine B;   18a-allyl-14α-O-methylmarcfortine B;   18a-propargyl-14α-O-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-methylmark Hortin B;   1,18a-bis-ethyl-14α-O-methylmarcfortine B;   1,18a-bis-benzyl-14α-O-methylmarcfortine B;   18a-ethyl-24-methoxy-14α-O-methylmarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-methylmarcfortine B;   18a-ethyl-24,25-dihydro-14α-O-methylmarcfortine B;   24,25-dihydro-14α-O-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-methylmarcfortine C;   1-propionyl-14α-O-methylmarcfortine C;   1-propyl-14α-O-methylmarcfortine C;   1-benzyl-14α-O-methylmarcfortine C;   18a-propyl-14α-O-methylmarcfortine C;   18a-benzyl-14α-O-methylmarcfortine C;   18a-methoxyethoxymethyl-14α-O-methylmarcfortine C;   18-allyl-14α-O-methylmarcfortine C;   18a-propargyl-14α-O-methylmarcfortine C;   1,18a-bis-propyl-14α-O-methylmarcfortine C;   1,18a-bis-benzyl-14α-O-methylmarcfortine C;   14α-O-methylmarcfortine C;   1-palmitoyl-14α-O-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-methylmarcfortine A;   1-palmitoyl-14α-O-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-methylmarcfortine D;   14α-O-methylmarcfortine D;   1-acetoxymethyl-14α-O-methylmarcfortine D;   1-diethoxyphosphoryl-14α-O-methylmarcfortine D;   1-dimethylsulfamoyl-14α-O-methylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-methylmarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-methylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-O-methylmarcfortine D ;   1-succinoyl-14α-O-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14α-O-methylmarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methylmarkholch D;   24-propoxy-24,25-dihydro-14α-O-methylmarcfortine D;   1- (p-toluenesulfonyl) -14α-O-methylmarcfortine D;   1-acetyl-14α-O-methylmarcfortine D;   1-methyl-14α-O-methylmarcfortine D;   1-benzyl-14α-O-methylmarcfortine D;   1-dimethylcarbamoyl-14α-O-methylmarcfortine D;   1-methoxycarbonyl-14α-O-methylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-methylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-methyl-14β-methylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-methylmarcfortine A;   1-Cyclopropylcarbonyl-14α-O-methyl-14β-methylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-methylmar Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-methylmer Lukhortin A;   1-succinoyl-14α-O-methyl-14β-methylmarcfortine A;   1- (4-morpholinosulfenyl) -14α-O-methyl-14β-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-methyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-methylmarkol Chin A;   1-acetyl-14α-O-methyl-14β-methylmarcfortine A;   1-methyl-14α-O-methyl-14β-methylmarcfortine A;   1-benzyl-14α-O-methyl-14β-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-methyl-14β-methylmarcfortine A ;   1-methoxycarbonyl-14α-O-methyl-14β-methylmarcfortine A;   14α-O-methyl-14β-methylmarcfortine B;   24,25-dihydro-14α-O-methyl-14β-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-methyl-14β-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-methylmarkol Chin B;   1-ethyl-14α-O-methyl-14β-methylmarcfortine B;   1-benzyl-14α-O-methyl-14β-methylmarcfortine B;   18a-ethyl-14α-O-methyl-14β-methylmarcfortine B;   18a-benzyl-14α-O-methyl-14β-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-methylmarkol Chin B;   18a-allyl-14α-O-methyl-14β-methylmarcfortine B;   18a-propargyl-14α-O-methyl-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-methyl-14β -Methylmarcfortine B;   1,18a-bis-ethyl-14α-O-methyl-14β-methylmarcfortine B;   1,18a-bis-benzyl-14α-O-methyl-14β-methylmarcfortine B ;   18a-Ethyl-24-methoxy-14α-O-methyl-14β-methylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-methyl-14β-methylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-methyl-14β-methylmark Hortin B;   24,25-dihydro-14α-O-methyl-14β-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-methyl-14β-methylmar Kuhortin C;   1-propionyl-14α-O-methyl-14β-methylmarcfortine C;   1-propyl-14α-O-methyl-14β-methylmarcfortine C;   1-benzyl-14α-O-methyl-14β-methylmarcfortine C;   18a-propyl-14α-O-methyl-14β-methylmarcfortine C;   18a-benzyl-14α-O-methyl-14β-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-methylmarkol Chin C;   18-allyl-14α-O-methyl-14β-methylmarcfortine C;   18a-propargyl-14α-O-methyl-14β-methylmarcfortine C;   1,18a-bis-propyl-14α-O-methyl-14β-methylmarcfortine C ;   1,18a-bis-benzyl-14α-O-methyl-14β-methylmarcfortine C ;   14α-O-methyl-14β-methylmarcfortine C;   1-palmitoyl-14α-O-methyl-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-methylmarkho Rutin A;   1-palmitoyl-14α-O-methyl-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-methylmarkho Rutin D;   14α-O-methyl-14β-methylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14α-O-methyl-14β-methylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-methylmarcfortine D;   1-Cyclopropylcarbonyl-14α-O-methyl-14β-methylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-methylmar Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-methylmer Lukhortin D;   1-succinoyl-14α-O-methyl-14β-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14α-O-methyl-14β-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-methyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-methylmarkol Chin D;   1-acetyl-14α-O-methyl-14β-methylmarcfortine D;   1-methyl-14α-O-methyl-14β-methylmarcfortine D;   1-benzyl-14α-O-methyl-14β-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-O-methyl-14β-ethylmarcfortine D ;   1-methoxycarbonyl-14α-O-methyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-O-methyl-14β-ethylmarcfortine A;   1-Dimethylsulfamoyl-14α-O-methyl-14β-ethylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-methyl-14β-ethylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-ethylmal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-ethylmer Lukhortin A;   1-succinoyl-14α-O-methyl-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-O-methyl-14β-ethylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-ethyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-ethylmal Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-ethylmarkol Chin A;   1-acetyl-14α-O-methyl-14β-ethylmarcfortine A;   1-methyl-14α-O-methyl-14β-ethylmarcfortine A;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-methyl-14β-ethylmarcfortine A ;   1-methoxycarbonyl-14α-O-methyl-14β-ethylmarcfortine A;   14α-O-methyl-14β-ethylmarcfortine B;   24,25-dihydro-14α-O-methyl-14β-ethylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-methyl-14β-ethylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-ethylmarkol Chin B;   1-ethyl-14α-O-methyl-14β-ethylmarcfortine B;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-ethyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-benzyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-ethylmarkol Chin B;   18a-allyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-propargyl-14α-O-methyl-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-methyl-14β -Ethylmarcfortine B;   1,18a-bis-ethyl-14α-O-methyl-14β-ethylmarcfortine B;   1,18a-bis-benzyl-14α-O-methyl-14β-ethylmarcfortine B ;   18a-ethyl-24-methoxy-14α-O-methyl-14β-ethylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-methyl-14β-ethylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-methyl-14β-ethylmark Hortin B;   24,25-dihydro-14α-O-methyl-14β-ethylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-methyl-14β-ethylmal Kuhortin C;   1-propionyl-14α-O-methyl-14β-ethylmarcfortine C;   1-propyl-14α-O-methyl-14β-ethylmarcfortine C;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-propyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-benzyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-methyl-14β-ethylmarkol Chin C;   18-allyl-14α-O-methyl-14β-ethylmarcfortine C;   18a-propargyl-14α-O-methyl-14β-ethylmarcfortine C;   1,18a-bis-propyl-14α-O-methyl-14β-ethylmarcfortine C ;   1,18a-bis-benzyl-14α-O-methyl-14β-ethylmarcfortine C ;   14α-O-methyl-14β-ethylmarcfortine C;   1-palmitoyl-14α-O-methyl-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-ethylmarkho Rutin A;   1-palmitoyl-14α-O-methyl-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-methyl-14β-ethylmarkho Rutin D;   14α-O-methyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-methyl-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14α-O-methyl-14β-ethylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-methyl-14β-ethylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-methyl-14β-ethylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-methyl-14β-ethylmal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-methyl-14β-ethylmer Lukhortin D;   1-succinoyl-14α-O-methyl-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-O-methyl-14β-ethylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-methyl-14β-ethyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-methyl-14β-ethylmal Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-methyl-14β-ethylmarkol Chin D;   1-acetyl-14α-O-methyl-14β-ethylmarcfortine D;   1-methyl-14α-O-methyl-14β-ethylmarcfortine D;   1-benzyl-14α-O-methyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-allyl marcfortine A;   14α-O-allyl marcfortine A;   14α-O-allyl-14β-methylmarcfortine A;   14α-O-allyl-14β-ethylmarcfortine A;   1-diethoxyphosphoryl-14α-O-allyl marcfortine A;   1-dimethylsulfamoyl-14α-O-allyl marcfortine A;   1-cyclopropylcarbonyl-14α-O-allyl marcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-allyl marcfortine A;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl marcfortine A ;   1-succinoyl-14α-O-allyl marcfortine A;   1- (4-morpholino sulphenyl) -14α-O-allyl marcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allylmarkholch A;   24-propoxy-24,25-dihydro-14α-O-allyl marcfortine A;   1- (p-toluenesulfonyl) -14α-O-allyl marcfortine A;   1-acetyl-14α-O-allyl marcfortine A;   1-methyl-14α-O-allyl marcfortine A;   1-benzyl-14α-O-allyl marcfortine A;   1-dimethylcarbamoyl-14α-O-allyl marcfortine A;   1-methoxycarbonyl-14α-O-allyl marcfortine A;   14α-O-allyl marcfortine B;   24,25-dihydro-14α-O-allyl marcfortine B;   24-methoxy-24,25-dihydro-14α-O-allyl marcfortine B;   1- (p-toluenesulfonyl) -14α-O-allyl marcfortine B;   1-ethyl-14α-O-allyl marcfortine B;   1-benzyl-14α-O-allyl marcfortine B;   18a-ethyl-14α-O-allyl marcfortine B;   18a-benzyl-14α-O-allyl marcfortine B;   18a-methoxyethoxymethyl-14α-O-allyl marcfortine B;   18a-allyl-14α-O-allyl marcfortine B;   18a-propargyl-14α-O-allylmarkottin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-allylmark Hortin B;   1,18a-bis-ethyl-14α-O-allyl marcfortine B;   1,18a-bis-benzyl-14α-O-allyl marcfortine B;   18a-Ethyl-24-methoxy-14α-O-allyl marcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-allyl marcfortine B;   18a-ethyl-24,25-dihydro-14α-O-allylmarkottin B;   24,25-dihydro-14α-O-allyl marcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-allyl marcfortine C;   1-propionyl-14α-O-allyl marcfortine C;   1-propyl-14α-O-allyl marcfortine C;   1-benzyl-14α-O-allyl marcfortine C;   18a-propyl-14α-O-allyl marcfortine C;   18a-benzyl-14α-O-allyl marcfortine C;   18a-methoxyethoxymethyl-14α-O-allyl marcfortine C;   18-allyl-14α-O-allyl marcfortine C;   18a-propargyl-14α-O-allyl marcfortine C;   1,18a-bis-propyl-14α-O-allyl marcfortine C;   1,18a-bis-benzyl-14α-O-allyl marcfortine C;   14α-O-allyl marcfortine C;   1-palmitoyl-14α-O-allyl marcfortine A;   1- (4-morpholinocarbonyl) -14α-O-allyl marcfortine A;   1-palmitoyl-14α-O-allyl marcfortine D;   1- (4-morpholinocarbonyl) -14α-O-allyl marcfortine D;   14α-O-allyl marcfortine D;   1-acetoxymethyl-14α-O-allyl marcfortine D;   1-diethoxyphosphoryl-14α-O-allyl marcfortine D;   1-dimethylsulfamoyl-14α-O-allylmarkottin D;   1-cyclopropylcarbonyl-14α-O-allyl marcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14α-O-allyl marcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl marcfortine D ;   1-succinoyl-14α-O-allyl marcfortine D;   1- (4-morpholinosulphenyl) -14α-O-allyl marcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allylmarkholch D;   24-propoxy-24,25-dihydro-14α-O-allyl marcfortine D;   1- (p-toluenesulfonyl) -14α-O-allyl marcfortine D;   1-acetyl-14α-O-allyl marcfortine D;   1-methyl-14α-O-allyl marcfortine D;   1-benzyl-14α-O-allyl marcfortine D;   1-dimethylcarbamoyl-14α-O-allyl marcfortine D;   1-methoxycarbonyl-14α-O-allyl marcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-methylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-allyl-14β-methylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-methylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-allyl-14β-methylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-methylmar Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-methylmer Lukhortin A;   1-succinoyl-14α-O-allyl-14β-methylmarcfortine A;   1- (4-morpholinosulfenyl) -14α-O-allyl-14β-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-methyl Rumarkfortin A;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-methylmarkol Chin A;   1-acetyl-14α-O-allyl-14β-methylmarcfortine A;   1-methyl-14α-O-allyl-14β-methylmarcfortine A;   1-benzyl-14α-O-allyl-14β-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-allyl-14β-methylmarcfortine A ;   1-methoxycarbonyl-14α-O-allyl-14β-methylmarcfortine A;   14α-O-allyl-14β-methylmarcfortine B;   24,25-dihydro-14α-O-allyl-14β-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-allyl-14β-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-methylmarkol Chin B;   1-ethyl-14α-O-allyl-14β-methylmarcfortine B;   1-benzyl-14α-O-allyl-14β-methylmarcfortine B;   18a-ethyl-14α-O-allyl-14β-methylmarcfortine B;   18a-benzyl-14α-O-allyl-14β-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-methylmarkol Chin B;   18a-allyl-14α-O-allyl-14β-methylmarcfortine B;   18a-propargyl-14α-O-allyl-14β-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-allyl-14β -Methylmarcfortine B;   1,18a-bis-ethyl-14α-O-allyl-14β-methylmarcfortine B;   1,18a-Bis-benzyl-14α-O-allyl-14β-methylmarcfortine B ;   18a-Ethyl-24-methoxy-14α-O-allyl-14β-methylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-allyl-14β-methylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-allyl-14β-methylmark Hortin B;   24,25-dihydro-14α-O-allyl-14β-methylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-allyl-14β-methylmar Kuhortin C;   1-propionyl-14α-O-allyl-14β-methylmarcfortine C;   1-propyl-14α-O-allyl-14β-methylmarcfortine C;   1-benzyl-14α-O-allyl-14β-methylmarcfortine C;   18a-propyl-14α-O-allyl-14β-methylmarcfortine C;   18a-benzyl-14α-O-allyl-14β-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-methylmarkol Chin C;   18-allyl-14α-O-allyl-14β-methylmarcfortine C;   18a-propargyl-14α-O-allyl-14β-methylmarcfortine C;   1,18a-bis-propyl-14α-O-allyl-14β-methylmarcfortine C ;   1,18a-bis-benzyl-14α-O-allyl-14β-methylmarcfortine C ;   14α-O-allyl-14β-methylmarcfortine C;   1-palmitoyl-14α-O-allyl-14β-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-methylmarkho Rutin A;   1-palmitoyl-14α-O-allyl-14β-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-methylmarkho Rutin D;   14α-O-allyl-14β-methylmarcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-methylmarcfortine D;   1-diethoxyphosphoryl-14α-O-allyl-14β-methylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-methylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-allyl-14β-methylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-methylmar Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-methylmer Lukhortin D;   1-succinoyl-14α-O-allyl-14β-methylmarcfortine D;   1- (4-morpholinosulfenyl) -14α-O-allyl-14β-methylmark E Rutin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-methyl Lemarc Hortin D;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-methylmarkol Chin D;   1-acetyl-14α-O-allyl-14β-methylmarcfortine D;   1-methyl-14α-O-allyl-14β-methylmarcfortine D;   1-benzyl-14α-O-allyl-14β-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-O-allyl-14β-ethylmarcfortine D ;   1-methoxycarbonyl-14α-O-allyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-ethylmarcfortine A;   1-Diethoxyphosphoryl-14α-O-allyl-14β-ethylmarcfortine A ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-ethylmarcfortine A;   1-cyclopropylcarbonyl-14α-O-allyl-14β-ethylmarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-ethylmal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-ethylmer Lukhortin A;   1-succinoyl-14α-O-allyl-14β-ethylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-O-allyl-14β-ethylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-ethyl Le Marcfortine A;   24-propoxy-24,25-dihydro-14α-O-allyl-14β-ethylmal Kuhortin A;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-ethylmarkol Chin A;   1-acetyl-14α-O-allyl-14β-ethylmarcfortine A;   1-methyl-14α-O-allyl-14β-ethylmarcfortine A;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine A;   1-Dimethylcarbamoyl-14α-O-allyl-14β-ethylmarcfortine A ;   1-methoxycarbonyl-14α-O-allyl-14β-ethylmarcfortine A;   14α-O-allyl-14β-ethylmarcfortine B;   24,25-dihydro-14α-O-allyl-14β-ethylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-O-allyl-14β-ethylmark Hortin B;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-ethylmarkol Chin B;   1-ethyl-14α-O-allyl-14β-ethylmarcfortine B;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-ethyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-benzyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-ethylmarkol Chin B;   18a-allyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-propargyl-14α-O-allyl-14β-ethylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-O-allyl-14β -Ethylmarcfortine B;   1,18a-bis-ethyl-14α-O-allyl-14β-ethylmarcfortine B;   1,18a-bis-benzyl-14α-O-allyl-14β-ethylmarcfortine B ;   18a-Ethyl-24-methoxy-14α-O-allyl-14β-ethylmarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-O-allyl-14β-ethylmarcfortine B;   18a-Ethyl-24,25-dihydro-14α-O-allyl-14β-ethylmark Hortin B;   24,25-dihydro-14α-O-allyl-14β-ethylmarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-O-allyl-14β-ethylmal Kuhortin C;   1-propionyl-14α-O-allyl-14β-ethylmarcfortine C;   1-propyl-14α-O-allyl-14β-ethylmarcfortine C;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-propyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-benzyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-Methoxyethoxymethyl-14α-O-allyl-14β-ethylmarkol Chin C;   18-allyl-14α-O-allyl-14β-ethylmarcfortine C;   18a-propargyl-14α-O-allyl-14β-ethylmarcfortine C;   1,18a-Bis-propyl-14α-O-allyl-14β-ethylmarcfortine C ;   1,18a-bis-benzyl-14α-O-allyl-14β-ethylmarcfortine C ;   14α-O-allyl-14β-ethylmarcfortine C;   1-palmitoyl-14α-O-allyl-14β-ethylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-ethylmarkho Rutin A;   1-palmitoyl-14α-O-allyl-14β-ethylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-O-allyl-14β-ethylmarkho Rutin D;   14α-O-allyl-14β-ethylmarcfortine D;   1-acetoxymethyl-14α-O-allyl-14β-ethylmarcfortine D;   1-diethoxyphosphoryl-14α-O-allyl-14β-ethylmarcfortine D ;   1-Dimethylsulfamoyl-14α-O-allyl-14β-ethylmarcfortine D;   1-cyclopropylcarbonyl-14α-O-allyl-14β-ethylmarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-O-allyl-14β-ethylmal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-O-allyl-14β-ethylmer Lukhortin D;   1-succinoyl-14α-O-allyl-14β-ethylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-O-allyl-14β-ethylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-O-allyl-14β-ethyl Lemarc Hortin D; 24-propoxy-24,25-dihydro-14α-O-allyl-14β-ethylmark Hortin D;   1- (p-toluenesulfonyl) -14α-O-allyl-14β-ethylmarkol Chin D;   1-acetyl-14α-O-allyl-14β-ethylmarcfortine D;   1-methyl-14α-O-allyl-14β-ethylmarcfortine D;   1-benzyl-14α-O-allyl-14β-ethylmarcfortine D;   14α-hydroxy-14β-methyl-15α-methylmarcfortine A;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl Ximarkfortin A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Rumarkfortin A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Tilmarkfortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methylmarcfortine A;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methylmarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methylmarcfortine A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Tilmarkfortin A;   1-Acetyl-14α-hydroxy-14β-methyl-15α-methylmarkholch A;   1-Methyl-14α-hydroxy-14β-methyl-15α-methylmarcfortine A;   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine A;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methylmer Lukhortin A;   14α-hydroxy-14β-methyl-15α-methylmarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methylmark Hortin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methylmarcfortine B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Tilmarkfortin B;   1-Ethyl-14α-hydroxy-14β-methyl-15α-methylmarcfortine B;   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch B   18a-Ethyl-14α-hydroxy-14β-methyl-15α-methylmarkol Chin B;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl marcfortine B;   18a-allyl-14α-hydroxy-14β-methyl-15α-methylmarkol Chin B;   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methyl-15α-methylmarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-methyl-15α-methylmer Lukhortin B;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methyl-15α-me Tilmarkfortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methylmarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methylmark Hortin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-14β-methyl-1 5α-methylmarcfortine C;   1-propionyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin C;   1-Propyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   18a-Propyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin C;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl marcfortine C;   18-allyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin C;   18-allyl-14α-hydroxy-14β-methyl-15α-methylmarkholch C   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin C;   1,18a-Bis-propyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine C;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl- Marcfortine C;   14α-hydroxy-14β-methyl-15α-methylmarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-14β-methyl-15α-methylmarcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl marcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl marcfortine D;   14α-hydroxy-14β-methyl-15α-methylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methylmar Kuhortin D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Lemarc Hortin D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Tilmarkfortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methylmarcfortine D;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methylmarkho Rutin D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methyl marcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methylmarcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methylmarcfortine D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Tilmarkfortin D;   1-Acetyl-14α-hydroxy-14β-methyl-15α-methylmarkholch D;   1-Methyl-14α-hydroxy-14β-methyl-15α-methylmarcfortine D;   1-benzyl-14α-hydroxy-14β-methyl-15α-methylmarkholch D;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl Marcfortine D;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methylmer Lukhortin D;   14α-hydroxy-15α-methylmarcfortine A;   1-acetoxymethyl-14α-hydroxy-15α-methylmarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-15α-methylxymarkol Chin A;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methylmarkholch A;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methylmarkol Chin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methylmer Lukhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methylmer Lukhortin A;   1-succinoyl-14α-hydroxy-15α-methylmarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methylmark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Tilmarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methylmar Kuhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methylmarkol Chin A;   1-acetyl-14α-hydroxy-15α-methylmarcfortine A;   1-methyl-14α-hydroxy-15α-methylmarcfortine A;   1-benzyl-14α-hydroxy-15α-methylmarcfortine A;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methylmarcfortine A;   1-Methoxycarbonyl-14α-hydroxy-15α-methylmarcfortine A ;   14α-hydroxy-15α-methylmarcfortine B;   24,25-dihydro-14α-hydroxy-15α-methylmarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-15α-methylmark Hortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methylmarkol Chin B;   1-ethyl-14α-hydroxy-15α-methylmarcfortine B;   1-benzyl-14α-hydroxy-15α-methylmarcfortine B;   18a-ethyl-14α-hydroxy-15α-methylmarcfortine B;   18a-benzyl-14α-hydroxy-15α-methylmarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methylmarkho Rutin B;   18a-allyl-14α-hydroxy-15α-methylmarcfortine B;   18a-propargyl-14α-hydroxy-15α-methylmarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-15 α-methylmarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-15α-methylmarcfortine B ;   1,18a-Bis-benzyl-14α-hydroxy-15α-methylmarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-15α-methylmarkol Chin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-15α-methylmark Hortin B;   24,25-dihydro-14α-hydroxy-15α-methylmarcfortine C;   1- (p-Bromobenzenesulfonyl) -14α-hydroxy-15α-methylmar Kuhortin C;   1-propionyl-14α-hydroxy-15α-methylmarcfortine C;   1-propyl-14α-hydroxy-15α-methylmarcfortine C;   1-benzyl-14α-hydroxy-15α-methylmarcfortine C;   18a-propyl-14α-hydroxy-15α-methylmarcfortine C;   18a-benzyl-14α-hydroxy-15α-methylmarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methylmarkho Rutin C;   18-allyl-14α-hydroxy-15α-methylmarcfortine C;   18a-propargyl-14α-hydroxy-15α-methylmarcfortine C;   1,18a-Bis-propyl-14α-hydroxy-15α-methylmarcfortine C;   1,18a-Bis-benzyl-14α-hydroxy-15α-methylmarcfortine C;   14α-hydroxy-15α-methylmarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-15α-methylmarcfortine A;   1-palmitoyl-14α-hydroxy-15α-methylmarcfortine A;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methylmarkho Rutin A;   1-palmitoyl-14α-hydroxy-15α-methylmarcfortine D;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methylmarkho Rutin D;   14α-hydroxy-15α-methylmarcfortine D;   1-acetoxymethyl-14α-hydroxy-15α-methylmarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-15α-methylmarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methylmarkholch D;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methylmarkol Chin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methylmer Lukhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methylmer Lukhortin D;   1-succinoyl-14α-hydroxy-15α-methylmarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methylmark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Tilmarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methylmar Kuhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methylmarkol Chin D;   1-acetyl-14α-hydroxy-15α-methylmarcfortine D;   1-methyl-14α-hydroxy-15α-methylmarcfortine D;   1-benzyl-14α-hydroxy-15α-methylmarcfortine D;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methylmarcfortine D; or   1-methoxycarbonyl-14α-hydroxy-15α-methylmarcfortine D The compound of claim 1 selected from the group consisting of: 9. 14β-methylmarcfortine A;   14β-ethylmarcfortine A;   14α-hydroxy-14β-ethylmarcfortine A;   14α-hydroxy-14β-methylmarcfortine A; or   Consists of 14α-hydroxy-14β-methyl-15α-methylmarcfortine A A compound according to claim 1 selected from the group. 10. The compound according to claim 1, which is 14α-hydroxymarcfortine A. 11. 14. It is 14α-hydroxy-15α-methylmarcfortine A. Compound of. 12. Is the treatment of livestock animals with an effective amount of the compound of claim 1? A method for treating or preventing helminth or arthropod insect infection in a slaughtered animal. 13. Treating a plant or soil in which it grows with an effective amount of the compound of claim 1. A method for treating a pest of the plant or a nematode pest. 14. Livestock helminths or arthropods comprising an inert carrier and the compound of claim 1. Compositions useful for the treatment and prevention of insect infections. 15. Plant insects and centigrades consisting of an inert carrier and a compound according to claim 1. A composition useful for the prevention and treatment of Pests. 16.   16-iodo-17-cyanomarcfortine A;   1-acetoxymethyl-16-iodo-17-cyanomarcfortine A;   1-diethoxyphosphoryl-16-iodo-17-cyanomarcfortine A;   1-dimethylsulfamoyl-16-iodo-17-cyanomarcfortine A;   1-cyclopropylcarbonyl-16-iodo-17-cyanomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-16-iodo-17-cyanomarkol Chin A;   1- (1-piperidinyl) thiocarbonyl-16-iodo-17-cyanomarkol Chin A;   1-succinoyl-16-iodo-17-cyanomarcfortine A;   1- (4-morpholinosulphenyl) -16-iodo-17-cyanomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -16-iodo-17-cyanomal Kuhortin A;   24-propoxy-24,25-dihydro-16-iodo-17-cyanomarkholch A;   1- (p-toluenesulfonyl) -16-iodo-17-cyanomarcfortine A;   1-acetyl-16-iodo-17-cyanomarcfortine A;   1-methyl-16-iodo-17-cyanomarcfortine A;   1-benzyl-16-iodo-17-cyanomarcfortine A;   1-dimethylcarmoyl-16-iodo-17-cyanomarcfortine A;   1-methoxycarbonyl-16-iodo-17-cyanomarcfortine A;   16-iodo-17-cyanomarcfortine B;   24,25-dihydro-16-iodo-17-cyanomarcfortine B;   24-Methoxy-24,25-dihydro-16-iodo-17-cyanomarcfortine B;   1- (p-toluenesulfonyl) -16-iodo-17-cyanomarcfortine B;   1-ethyl-16-iodo-17-cyanomarcfortine B;   1-benzyl-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-16-iodo-17-cyanomarcfortine B;   18a-benzyl-16-iodo-17-cyanomarcfortine B;   18a-Methoxyethoxymethyl-16-iodo-17-cyanomarcfortine B ;   18a-allyl-16-iodo-17-cyanomarcfortine B;   18a-propargyl-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-16-iodo-17-cyano Marcfortine B;   1,18a-bis-ethyl-16-iodo-17-cyanomarcfortine B;   1,18a-bis-benzyl-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-24-methoxy-16-iodo-17-cyanomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-16-iodo-17-cyanomarcfortine B;   18a-Ethyl-24,25-dihydro-16-iodo-17-cyanomarcfortine B;   24,25-dihydro-16-iodo-17-cyanomarcfortine C;   1- (p-bromobenzenesulfonyl) -16-iodo-17-cyanomarcforty C   1-propionyl-16-iodo-17-cyanomarcfortine C;   1-propyl-16-iodo-17-cyanomarcfortine C;   1-benzyl-16-iodo-17-cyanomarcfortine C;   18a-Propyl-16-iodo-17-cyanomarcfortine C;   18a-benzyl-16-iodo-17-cyanomarcfortine C;   18a-Methoxyethoxymethyl-16-iodo-17-cyanomarcfortine C ;   18-allyl-16-iodo-17-cyanomarcfortine C;   18a-propargyl-16-iodo-17-cyanomarcfortine C;   1,18a-bis-propyl-16-iodo-17-cyanomarcfortine C;   1,18a-bis-benzyl-16-iodo-17-cyanomarcfortine C;   16-iodo-17-cyanomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-16- Iodo-17-cyanomarcfortine A;   1-palmitoyl-16-iodo-17-cyanomarcfortine A;   1- (4-morpholinocarbonyl) -16-iodo-17-cyanomarcfortine A ;   1-palmitoyl-16-iodo-17-cyanomarcfortine D;   1- (4-morpholinocarbonyl) -16-iodo-17-cyanomarcfortine D ;   16-iodo-17-cyanomarcfortine D;   1-acetoxymethyl-16-iodo-17-cyanomarcfortine D;   1-diethoxyphosphoryl-16-iodo-17-cyanomarcfortine D;   1-dimethylsulfamoyl-16-iodo-17-cyanomarcfortine D;   1-cyclopropylcarbonyl-16-iodo-17-cyanomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-16-iodo-17-cyanomarkol Chin D;   1- (1-piperidinyl) thiocarbonyl-16-iodo-17-cyanomarkol Chin D;   1-succinoyl-16-iodo-17-cyanomarcfortine D;   1- (4-morpholinosulphenyl) -16-iodo-17-cyanomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -16-iodo-17-cyanomal Kuhortin D;   24-propoxy-24,25-dihydro-16-iodo-17-cyanomarkholch D;   1- (p-toluenesulfonyl) -16-iodo-17-cyanomarcfortine D;   1-acetyl-16-iodo-17-cyanomarcfortine D;   1-methyl-16-iodo-17-cyanomarcfortine D;   1-benzyl-16-iodo-17-cyanomarcfortine D;   1-dimethylcarbamoyl-16-iodo-17-cyanomarcfortine D;   1-methoxycarbonyl-16-iodo-17-cyanomarcfortine D;   16,17-dehydro-17-cyanomarcfortine A;   1-acetoxymethyl-16,17-dehydro-17-cyanomarcfortine A;   1-diethoxyphosphoryl-16,17-dehydro-17-cyanomarcfortine A ;   1-Dimethylsulfamoyl-16,17-dehydro-17-cyanomarcfortine A;   1-cyclopropylcarbonyl-16,17-dehydro-17-cyanomarcforty A;   2-bicyclo [2. 2. 1] Heptanoyl-16,17-dehydro-17-cyanomal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-16,17-dehydro-17-cyanomer Lukhortin A;   1-succinoyl-16,17-dehydro-17-cyanomarcfortine A;   1- (4-morpholinosulphenyl) -16,17-dehydro-17-cyanomark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -16,17-dehydro-17-sia Nomarc Hortin A;   24-propoxy-24,25-dihydro-16,17-dehydro-17-cyanomal Kuhortin A;   1- (p-toluenesulfonyl) -16,17-dehydro-17-cyanomarkol Chin A;   1-acetyl-16,17-dehydro-17-cyanomarcfortine A;   1-methyl-16,17-dehydro-17-cyanomarcfortine A;   1-benzyl-16,17-dehydro-17-cyanomarcfortine A;   1-Dimethylcarbamoyl-16,17-dehydro-17-cyanomarcfortine A ;   1-methoxycarbonyl-16,17-dehydro-17-cyanomarcfortine A;   16,17-dehydro-17-cyanomarcfortine B;   24,25-dihydro-16,17-dehydro-17-cyanomarcfortine B;   24-Methoxy-24,25-dihydro-16,17-dehydro-17-cyanomark Hortin B;   1- (p-toluenesulfonyl) -16,17-dehydro-17-cyanomarkol Chin B;   1-ethyl-16,17-dehydro-17-cyanomarcfortine B;   1-benzyl-16,17-dehydro-17-cyanomarcfortine B;   18a-Ethyl-16,17-dehydro-17-cyanomarcfortine B;   18a-benzyl-16,17-dehydro-17-cyanomarcfortine B;   18a-methoxyethoxymethyl-16,17-dehydro-17-cyanomarkol Chin B;   18a-allyl-16,17-dehydro-17-cyanomarcfortine B;   18a-propargyl-16,17-dehydro-17-cyanomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-16,17-dehydro-17 -Cyanomarcfortine B;   1,18a-bis-ethyl-16,17-dehydro-17-cyanomarcfortine B;   1,18a-Bis-benzyl-16,17-dehydro-17-cyanomarcfortine B ;   18a-Ethyl-24-methoxy-16,17-dehydro-17-cyanomarcforty B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-16,17-dehydro-17-cyanomarcfortine B;   18a-Ethyl-24,25-dihydro-16,17-dehydro-17-cyanomark Hortin B;   24,25-dihydro-16,17-dehydro-17-cyanomarcfortine C;   1- (p-bromobenzenesulfonyl) -16,17-dehydro-17-cyanomal Kuhortin C;   1-propionyl-16,17-dehydro-17-cyanomarcfortine C;   1-propyl-16,17-dehydro-17-cyanomarcfortine C;   1-benzyl-16,17-dehydro-17-cyanomarcfortine C;   18a-propyl-16,17-dehydro-17-cyanomarcfortine C;   18a-benzyl-16,17-dehydro-17-cyanomarcfortine C;   18a-methoxyethoxymethyl-16,17-dehydro-17-cyanomarkol Chin C;   18-allyl-16,17-dehydro-17-cyanomarcfortine C;   18a-propargyl-16,17-dehydro-17-cyanomarcfortine C;   1,18a-bis-propyl-16,17-dehydro-17-cyanomarcfortine C ;   1,18a-Bis-benzyl-16,17-dehydro-17-cyanomarcfortine C ;   16,17-dehydro-17-cyanomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-16, 17-dehydro-17-cyanomarcfortine A;   1-palmitoyl-16,17-dehydro-17-cyanomarcfortine A;   1- (4-morpholinocarbonyl) -16,17-dehydro-17-cyanomarkho Rutin A;   1-palmitoyl-16,17-dehydro-17-cyanomarcfortine D;   1- (4-morpholinocarbonyl) -16,17-dehydro-17-cyanomarkho Rutin D;   16,17-dehydro-17-cyanomarcfortine D;   1-acetoxymethyl-16,17-dehydro-17-cyanomarcfortine D;   1-diethoxyphosphoryl-16,17-dehydro-17-cyanomarcfortine D;   1-Dimethylsulfamoyl-16,17-dehydro-17-cyanomarcfortine D;   1-cyclopropylcarbonyl-16,17-dehydro-17-cyanomarcforty D;   2-bicyclo [2. 2. 1] Heptanoyl-16,17-dehydro-17-cyanomal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-16,17-dehydro-17-cyanomer Lukhortin D;   1-succinoyl-16,17-dehydro-17-cyanomarcfortine D;   1- (4-morpholinosulphenyl) -16,17-dehydro-17-cyanomark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -16,17-dehydro-17-sia Nomarc Hortin D;   24-propoxy-24,25-dihydro-16,17-dehydro-17-cyanomal Kuhortin D;   1- (p-toluenesulfonyl) -16,17-dehydro-17-cyanomarkol Chin D;   1-acetyl-16,17-dehydro-17-cyanomarcfortine D;   1-methyl-16,17-dehydro-17-cyanomarcfortine D;   1-benzyl-16,17-dehydro-17-cyanomarcfortine D;   1-Dimethylcarbamoyl-16,17-dehydro-17-cyanomarcfortine D ;   1-methoxycarbonyl-16,17-dehydro-17-cyanomarcfortine D;   17-ketomarkhortin A;   1-acetoxymethyl-17-ketomarcfortine A;   1-diethoxyphosphoryl-17-ketoxoxymarkottin A;   1-dimethylsulfamoyl-17-ketomarkfortin A;   1-cyclopropylcarbonyl-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-17-ketomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-17-ketomarcfortine A;   1-succinoyl-17-ketomarkfortin A;   1- (4-morpholinosulphenyl) -17-ketomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -17-ketomarcfortine A;   24-propoxy-24,25-dihydro-17-ketomarcfortine A;   1- (p-toluenesulfonyl) -17-ketomarcfortine A;   1-acetyl-17-ketomarcfortine A;   1-methyl-17-ketomarcfortine A;   1-benzyl-17-ketomarcfortine A;   1-dimethylcarbamoyl-17-ketomarcfortine A;   1-methoxycarbonyl-17-ketomarcfortine A;   17-ketomarkhortin B;   24,25-dihydro-17-ketomarcfortine B;   24-methoxy-24,25-dihydro-17-ketomarcfortine B;   1- (p-toluenesulfonyl) -17-ketomarcfortine B;   1-ethyl-17-ketomarcfortine B;   1-benzyl-17-ketomarcfortine B;   18a-ethyl-17-ketomarcfortine B;   18a-benzyl-17-ketomarcfortine B;   18a-methoxyethoxymethyl-17-ketomarcfortine B;   18a-allyl-17-ketomarcfortine B;   18a-propargyl-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-17-ketomarcfortine B;   1,18a-bis-ethyl-17-ketomarcfortine B;   1,18a-bis-benzyl-17-ketomarcfortine B;   18a-ethyl-24-methoxy-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-ethyl-24,25-dihydro-17-ketomarcfortine B;   24,25-dihydro-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -17-ketomarcfortine C;   1-propionyl-17-ketomarcfortine C;   1-propyl-17-ketomarcfortine C;   1-benzyl-17-ketomarcfortine C;   18a-propyl-17-ketomarcfortine C;   18a-benzyl-17-ketomarcfortine C;   18a-methoxyethoxymethyl-17-ketomarcfortine C;   18-allyl-17-ketomarcfortine C;   18a-propargyl-17-ketomarcfortine C;   1,18a-bis-propyl-17-ketomarcfortine C;   1,18a-bis-benzyl-17-ketomarcfortine C;   17-ketomarkhortin C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-17- Ketomarkhortin A;   1-palmitoyl-17-ketomarcfortine A;   1- (4-morpholinocarbonyl) -17-ketomarcfortine A;   1-palmitoyl-17-ketomarcfortine D;   1- (4-morpholinocarbonyl) -17-ketomarcfortine D;   17-ketodroxymarcfortine D;   1-acetoxymethyl-17-ketomarcfortine D;   1-diethoxyphosphoryl-17-ketomarcfortine D;   1-dimethylsulfamoyl-17-ketomarcfortine D;   1-cyclopropylcarbonyl-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-17-ketomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-17-ketomarcfortine D;   1-succinoyl-17-ketomarkfortin D;   1- (4-morpholinosulphenyl) -17-ketomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -17-ketomarcfortine D;   24-propoxy-24,25-dihydro-17-ketomarcfortine D;   1- (p-toluenesulfonyl) -17-ketomarcfortine D;   1-acetyl-17-ketomarcfortine D;   1-methyl-17-ketomarcfortine D;   1-benzyl-17-ketomarcfortine D;   1-dimethylcarbamoyl-17-ketomarcfortine D;   1-methoxycarbonyl-17-ketomarcfortine D;   15,16-dehydro-17-ketomarcfortine A;   1-acetoxymethyl-15,16-dehydro-17-ketomarcfortine A;   1-diethoxyphosphoryl-15,16-dehydro-17-ketoxymarkfortin A;   1-Dimethylsulfamoyl-15,16-dehydro-17-ketomarcfortine A ;   1-cyclopropylcarbonyl-15,16-dehydro-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-17-ketomark Hortin A;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-17-ketomal Kuhortin A;   1-succinoyl-15,16-dehydro-17-ketomarcfortine A;   1- (4-morpholinosulfenyl) -15,16-dehydro-17-ketomarcho Rutin A;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-17-keto Ma Lukhortin A;   24-propoxy-24,25-dihydro-15,16-dehydro-17-ketomark Hortin A;   1- (p-toluenesulfonyl) -15,16-dehydro-17-ketomarkholch A;   1-acetyl-15,16-dehydro-17-ketomarcfortine A;   1-methyl-15,16-dehydro-17-ketomarcfortine A;   1-benzyl-15,16-dehydro-17-ketomarcfortine A;   1-dimethylcarbamoyl-15,16-dehydro-17-ketomarcfortine A;   1-methoxycarbonyl-15,16-dehydro-17-ketomarcfortine A;   15,16-dehydro-17-ketomarcfortine B;   24,25-dihydro-15,16-dehydro-17-ketomarcfortine B;   24-Methoxy-24,25-dihydro-15,16-dehydro-17-ketomarcho Rutin B;   1- (p-toluenesulfonyl) -15,16-dehydro-17-ketomarkholch B   1-ethyl-15,16-dehydro-17-ketomarcfortine B;   1-benzyl-15,16-dehydro-17-ketomarcfortine B;   18a-Ethyl-15,16-dehydro-17-ketomarcfortine B;   18a-benzyl-15,16-dehydro-17-ketomarcfortine B;   18a-Methoxyethoxymethyl-15,16-dehydro-17-ketomarkholch B   18a-allyl-15,16-dehydro-17-ketomarcfortine B;   18a-propargyl-15,16-dehydro-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-15,16-dehydro-17 -Ketmarkhortin B;   1,18a-bis-ethyl-15,16-dehydro-17-ketomarcfortine B;   1,18a-bis-benzyl-15,16-dehydro-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-15,16-dehydro-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-15,16-dehydro-17-ketomarcho Rutin B;   24,25-dihydro-15,16-dehydro-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -15,16-dehydro-17-ketomark Hortin C;   1-propionyl-15,16-dehydro-17-ketomarcfortine C;   1-propyl-15,16-dehydro-17-ketomarcfortine C;   1-benzyl-15,16-dehydro-17-ketomarcfortine C;   18a-Propyl-15,16-dehydro-17-ketomarcfortine C;   18a-benzyl-15,16-dehydro-17-ketomarcfortine C;   18a-Methoxyethoxymethyl-15,16-dehydro-17-ketomarkholch C   18-allyl-15,16-dehydro-17-ketomarcfortine C;   18a-propargyl-15,16-dehydro-17-ketomarcfortine C;   1,18a-bis-propyl-15,16-dehydro-17-ketomarcfortine C;   1,18a-bis-benzyl-15,16-dehydro-17-ketomarcfortine C;   15,16-dehydro-17-ketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-15, 16-dehydro-17-ketomarcfortine A;   1-palmitoyl-15,16-dehydro-17-ketomarcfortine A;   1- (4-morpholinocarbonyl) -15,16-dehydro-17-ketomarkol Chin A;   1-palmitoyl-15,16-dehydro-17-ketomarcfortine D;   1- (4-morpholinocarbonyl) -15,16-dehydro-17-ketomarkol Chi D;   15,16-dehydro-17-ketomarcfortine D;   1-acetoxymethyl-15,16-dehydro-17-ketomarcfortine D;   1-diethoxyphosphoryl-15,16-dehydro-17-ketomarcfortine D;   1-dimethylsulfamoyl-15,16-dehydro-17-ketomarcfortine D ;   1-cyclopropylcarbonyl-15,16-dehydro-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-17-ketomark Hortin D;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-17-ketomal Kuhortin D;   1-succinoyl-15,16-dehydro-17-ketomarcfortine D;   1- (4-morpholinosulfenyl) -15,16-dehydro-17-ketomarcho Rutin D;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-17-keto Marcfortine D;   24-propoxy-24,25-dihydro-15,16-dehydro-17-ketomark Hortin D;   1- (p-toluenesulfonyl) -15,16-dehydro-17-ketomarkholch D;   1-acetyl-15,16-dehydro-17-ketomarcfortine D;   1-methyl-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-15,16-dehydro-17-ketomarcfortine D;   1-dimethylcarbamoyl-15,16-dehydro-17-ketomarcfortine D;   1-methoxycarbonyl-15,16-dehydro-17-ketomarcfortine D;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin A;   1-diethoxyphosphoryl-14α-hydroxy-15,16-dehydro-17-keto Ximarkfortin A;   1-Dimethylsulfamoyl-14α-hydroxy-15,16-dehydro-17-ke Tomarkfortin A;   1-cyclopropylcarbonyl-14α-hydroxy-15,16-dehydro-17- Ketomarkhortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15,16-dehi Doro-17-ketomarkhortin A;   1-succinoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinosulphenyl) -14α-hydroxy-15,16-dehydro- 17-ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15,16- Dehydro-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-15,16-dehydro-17 -Ketmarkhortin A;   1-Acetyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch A;   1-Methyl-14α-hydroxy-15,16-dehydro-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch A;   1-Dimethylcarbamoyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine A;   1-Methoxycarbonyl-14α-hydroxy-15,16-dehydro-17-ketomer Lukhortin A;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine B;   24,25-dihydro-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-15,16-dehydro- 17-ketomarkhortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-15,16-dehydro-17 -Ketmarkhortin B;   1-Ethyl-14α-hydroxy-15,16-dehydro-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch B   18a-Ethyl-14α-hydroxy-15,16-dehydro-17-ketomarkol Chin B;   18a-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkho Rutin B;   18a-Methoxyethoxymethyl-14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin B;   18a-allyl-14α-hydroxy-15,16-dehydro-17-ketomarkol Chin B;   18a-Propargyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin B;   18a-ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-15, 16-dehydro-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-15,16-dehydro-17-ketomer Lukhortin B;   1,18a-bis-benzyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-15,16-dehydro-17- Ketomarkhortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-15,16-dehydro- 17-ketomarkhortin B;   24,25-dihydro-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin C;   1-propionyl-14α-hydroxy-15,16-dehydro-17-ketomarkouf Rutin C;   1-propyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch C   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch C   18a-Propyl-14α-hydroxy-15,16-dehydro-17-ketomarkho Rutin C;   18a-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkho Rutin C;   18a-Methoxyethoxymethyl-14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin C;   18-allyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch C   18a-Propargyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin C;   1,18a-bis-propyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine C;   1,18a-bis-benzyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine C;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-15,16-dehydro-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin A;   1-palmitoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-15,16-dehydro-1 7-ketomarkhortin D;   14α-hydroxy-15,16-dehydro-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-15,16-dehydro-17-ketomal Kuhortin D;   1-diethoxyphosphoryl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-15,16-dehydro-17-ke Tomarkfortin D;   1-cyclopropylcarbonyl-14α-hydroxy-15,16-dehydro-17- Ketomarkhortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15,16-dehi Doro-17-ketomarkhortin D;   1-succinoyl-14α-hydroxy-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinosulphenyl) -14α-hydroxy-15,16-dehydro- 17-ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15,16- Dehydro-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-15,16-dehyde Ro-17-ketomarkhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-15,16-dehydro-17 -Ketmarkhortin D;   1-Acetyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch D;   1-Methyl-14α-hydroxy-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-15,16-dehydro-17-ketomarkholch D;   1-Dimethylcarbamoyl-14α-hydroxy-15,16-dehydro-17-keto Marcfortine D;   1-Methoxycarbonyl-14α-hydroxy-15,16-dehydro-17-ketomer Lukhortin D;   14α-hydroxy-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-17-ketomarcfortine A;   1-diethoxyphosphoryl-14α-hydroxy-17-ketoxymarkfortin A;   1-Dimethylsulfamoyl-14α-hydroxy-17-ketomarcfortine A ;   1-Cyclopropylcarbonyl-14α-hydroxy-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-17-ketomark Hortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-17-ketomark Hortin A;   1-succinoyl-14α-hydroxy-17-ketomarcfortine A;   1- (4-morpholinosulphenyl) -14α-hydroxy-17-ketomarkol Chin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-17-keto Marcfortine A;   24-propoxy-24,25-dihydro-14α-hydroxy-17-ketomarcho Rutin A;   1 (p-toluenesulfonyl) -14α-hydroxy-17-ketomarcfortine A;   1-acetyl-14α-hydroxy-17-ketomarcfortine A;   1-methyl-14α-hydroxy-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-17-ketomarcfortine A;   1-dimethylcarbamoyl-14α-hydroxy-17-ketomarcfortine A;   1-methoxycarbonyl-14α-hydroxy-17-ketomarcfortine A;   14α-hydroxy-17-ketomarcfortine B;   24,25-dihydro-14α-hydroxy-17-ketomarcfortine B;   24-Methoxy-24,25-dihydro-14α-hydroxy-17-ketomarkol Chin B;   1- (p-toluenesulfonyl) -14α-hydroxy-17-ketomarcfortine B;   1-ethyl-14α-hydroxy-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-17-ketomarcfortine B;   18a-ethyl-14α-hydroxy-17-ketomarcfortine B;   18a-benzyl-14α-hydroxy-17-ketomarcfortine B;   18a-Methoxyethoxymethyl-14α-hydroxy-17-ketomarkholchti B   18a-allyl-14α-hydroxy-17-ketomarcfortine B;   18a-propargyl-14α-hydroxy-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-17- Ketomarkhortin B;   1,18a-bis-ethyl-14α-hydroxy-17-ketomarcfortine B;   1,18a-bis-benzyl-14α-hydroxy-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-14α-hydroxy-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-17-ketomarkol Chin B;   24,25-dihydro-14α-hydroxy-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-17-ketomarkho Rutin C;   1-propionyl-14α-hydroxy-17-ketomarcfortine C;   1-propyl-14α-hydroxy-17-ketomarcfortine C;   1-benzyl-14α-hydroxy-17-ketomarcfortine C;   18a-propyl-14α-hydroxy-17-ketomarcfortine C;   18a-benzyl-14α-hydroxy-17-ketomarcfortine C;   18a-Methoxyethoxymethyl-14α-hydroxy-17-ketomarkholchti C   18-allyl-14α-hydroxy-17-ketomarcfortine C;   18a-propargyl-14α-hydroxy-17-ketomarcfortine C;   1,18a-bis-propyl-14α-hydroxy-17-ketomarcfortine C;   1,18a-bis-benzyl-14α-hydroxy-17-ketomarcfortine C;   14α-hydroxy-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3yl) carbonyl-14α- Hi Droxy-17-ketomarkfortin A;   1-palmitoyl-14α-hydroxy-17-ketomarkfortin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-17-ketomarcholch A;   1-palmitoyl-14α-hydroxy-17-ketomarkfortin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-17-ketomarcholch D;   14α-hydroxy-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-17-ketomarcfortine D;   1-diethoxyphosphoryl-14α-hydroxy-17-ketomarcfortine D;   1-Dimethylsulfamoyl-14α-hydroxy-17-ketomarcfortine D ;   1-Cyclopropylcarbonyl-14α-hydroxy-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-17-ketomark Hortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-17-ketomark Hortin D;   1-succinoyl-14α-hydroxy-17-ketomarcfortine D;   1- (4-morpholinosulphenyl) -14α-hydroxy-17-ketomarkol Chin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-17-keto Marcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-17-ketomarcho Rutin D;   1- (p-toluenesulfonyl) -14α-hydroxy-17-ketomarcfortine D;   1-acetyl-14α-hydroxy-17-ketomarcfortine D;   1-methyl-14α-hydroxy-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-17-ketomarcfortine D;   1-dimethylcarbamoyl-14α-hydroxy-17-ketomarcfortine D;   1-methoxycarbonyl-14α-hydroxy-17-ketomarcfortine D;   14,17-diketomarkottin A;   1-acetoxymethyl-14,17-diketomarkfortin A;   1-diethoxyphosphoryl-14,17-diketoxymarcfortine A;   1-dimethylsulfamoyl-14,17-diketomarkfortin A;   1-cyclopropylcarbonyl-14,17-diketomarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14,17-diketomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-14,17-diketomarcfortine A ;   1-succinoyl-14,17-diketomarkfortin A;   1- (4-morpholinosulphenyl) -14,17-diketomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14,17-diketomarkholch A;   24-propoxy-24,25-dihydro-14,17-diketomarcfortine A;   1- (p-toluenesulfonyl) -14,17-diketomarcfortine A;   1-acetyl-14,17-diketomarkfortin A;   1-methyl-14,17-diketomarcfortine A;   1-benzyl-14,17-diketomarcfortine A;   1-dimethylcarbamoyl-14,17-diketomarkfortin A;   1-methoxycarbonyl-14,17-diketomarcfortine A;   14,17-diketomarkfortin B;   24,25-dihydro-14,17-diketomarkfortin B;   24-methoxy-24,25-dihydro-14,17-diketomarcfortine B;   1- (p-toluenesulfonyl) -14,17-diketomarcfortine B;   1-ethyl-14,17-diketomarcfortine B;   1-benzyl-14,17-diketomarcfortine B;   18a-ethyl-14,17-diketomarkfortin B;   18a-benzyl-14,17-diketomarkfortin B;   18a-methoxyethoxymethyl-14,17-diketomarcfortine B;   18a-allyl-14,17-diketomarcfortine B;   18a-propargyl-14,17-diketomarkfortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14,17-diketomark Hortin B;   1,18a-bis-ethyl-14,17-diketomarcfortine B;   1,18a-bis-benzyl-14,17-diketomarcfortine B;   18a-Ethyl-24-methoxy-14,17-diketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14,17-diketomarcfortine B;   24,25-dihydro-14,17-diketomarcfortine C;   1- (p-bromobenzenesulfonyl) -14,17-diketomarcfortine C;   1-propionyl-14,17-diketomarkfortin C;   1-propyl-14,17-diketomarkfortin C;   1-benzyl-14,17-diketomarcfortine C;   18a-propyl-14,17-diketomarcfortine C;   18a-benzyl-14,17-diketomarkfortin C;   18a-methoxyethoxymethyl-14,17-diketomarcfortine C;   18-allyl-14,17-diketomarcfortine C;   18a-propargyl-14,17-diketomarkfortin C;   1,18a-bis-propyl-14,17-diketomarkfortin C;   1,18a-bis-benzyl-14,17-diketomarkfortin C;   14,17-Diketomarkfortin C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-14,1 7-diketomarkfortin A;   1-palmitoyl-14,17-diketomarkfortin A;   1- (4-morpholinocarbonyl) -14,17-diketomarcfortine A;   1-palmitoyl-14,17-diketomarkfortin D;   1- (4-morpholinocarbonyl) -14,17-diketomarkfortin D;   14,17-Diketomarkfortin D;   1-acetoxymethyl-14,17-diketomarcfortine D;   1-diethoxyphosphoryl-14,17-diketomarcfortine D;   1-dimethylsulfamoyl-14,17-diketomarkfortin D;   1-cyclopropylcarbonyl-14,17-diketomarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14,17-diketomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-14,17-diketomarcfortine D ;   1-succinoyl-14,17-diketomarkfortin D;   1- (4-morpholinosulphenyl) -14,17-diketomarkfortin D;   1- (2,4-dinitrobenzenesulfenyl) -14,17-diketomarkholch D;   24-propoxy-24,25-dihydro-14,17-diketomarkfortin D;   1- (p-toluenesulfonyl) -14,17-diketomarcfortine D;   1-acetyl-14,17-diketomarcfortine D;   1-methyl-14,17-diketomarcfortine D;   1-benzyl-14,17-diketomarkfortin D;   1-dimethylcarbamoyl-14,17-diketomarkfortin D;   1-methoxycarbonyl-14,17-diketomarcfortine D;   15,16-dehydro-14,17-diketomarcfortine A;   1-acetoxymethyl-15,16-dehydro-14,17-diketomarcfortine A;   1-diethoxyphosphoryl-15,16-dehydro-14,17-diketoxymark Hortin A;   1-Dimethylsulfamoyl-15,16-dehydro-14,17-diketomarko Rutin A;   1-cyclopropylcarbonyl-15,16-dehydro-14,17-diketomark Hortin A;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-14,17-dike Tomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-14,17-dike Tomarkfortin A;   1-succinoyl-15,16-dehydro-14,17-diketomarcfortine A;   1- (4-morpholinosulfenyl) -15,16-dehydro-14,17-diketomas Lukhortin A;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-14,17 -Diketmarkfortin A;   24-propoxy-24,25-dihydro-15,16-dehydro-14,17-diketo Marcfortine A;   1- (p-toluenesulfonyl) -15,16-dehydro-14,17-diketomark Hortin A;   1-acetyl-15,16-dehydro-14,17-diketomarcfortine A;   1-methyl-15,16-dehydro-14,17-diketomarcfortine A;   1-benzyl-15,16-dehydro-14,17-diketomarcfortine A;   1-Dimethylcarbamoyl-15,16-dehydro-14,17-diketomarkol Chin A;   1-methoxycarbonyl-15,16-dehydro-14,17-diketomarkholch A;   15,16-dehydro-14,17-diketomarkfortin B;   24,25-dihydro-15,16-dehydro-14,17-diketomarcfortine B ;   24-Methoxy-24,25-dihydro-15,16-dehydro-14,17-diketomers Lukhortin B;   1- (p-toluenesulfonyl) -15,16-dehydro-14,17-diketomark E Rutin B;   1-ethyl-15,16-dehydro-14,17-diketomarcfortine B;   1-benzyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-Ethyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-benzyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-Methoxyethoxymethyl-15,16-dehydro-14,17-diketomal Kuhortin B;   18a-allyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-propargyl-15,16-dehydro-14,17-diketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-15,16-dehydro-14 , 17-Diketomarkfortin B;   1,18a-bis-ethyl-15,16-dehydro-14,17-diketomarkholch B   1,18a-bis-benzyl-15,16-dehydro-14,17-diketomarkol Chin B;   18a-Ethyl-24-methoxy-15,16-dehydro-14,17-diketomark Hortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-15,16-dehydro-14,17-diketomas Lukhortin B;   24,25-dihydro-15,16-dehydro-14,17-diketomarcfortine C ;   1- (p-bromobenzenesulfonyl) -15,16-dehydro-14,17-diketo Marcfortine C;   1-propionyl-15,16-dehydro-14,17-diketomarcfortine C;   1-propyl-15,16-dehydro-14,17-diketomarcfortine C;   1-benzyl-15,16-dehydro-14,17-diketomarkfortin C;   18a-propyl-15,16-dehydro-14,17-diketomarcfortine C;   18a-benzyl-15,16-dehydro-14,17-diketomarcfortine C;   18a-Methoxyethoxymethyl-15,16-dehydro-14,17-diketomal Kuhortin C;   18-allyl-15,16-dehydro-14,17-diketomarcfortine C;   18a-propargyl-15,16-dehydro-14,17-diketomarcfortine C;   1,18a-bis-propyl-15,16-dehydro-14,17-diketomarkol Chin C;   1,18a-bis-benzyl-15,16-dehydro-14,17-diketomarkol Chin C;   15,16-dehydro-14,17-diketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-15,1 6-dehydro-14,17-diketomarcfortine A;   1-palmitoyl-15,16-dehydro-14,17-diketomarcfortine A;   1- (4-morpholinocarbonyl) -15,16-dehydro-14,17-diketomal Kuhortin A;   1-palmitoyl-15,16-dehydro-14,17-diketomarcfortine D;   1- (4-morpholinocarbonyl) -15,16-dehydro-14,17-diketomal Kuhortin D;   15,16-dehydro-14,17-diketomarkfortin D;   1-acetoxymethyl-15,16-dehydro-14,17-diketomarcfortine D;   1-diethoxyphosphoryl-15,16-dehydro-14,17-diketomarkol Chin D;   1-Dimethylsulfamoyl-15,16-dehydro-14,17-diketomarko Rutin D;   1-cyclopropylcarbonyl-15,16-dehydro-14,17-diketomark Hortin D;   2-bicyclo [2. 2. 1] Heptanoyl-15,16-dehydro-14,17-dike Tomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-15,16-dehydro-14,17-dike Tomarkfortin D;   1-succinoyl-15,16-dehydro-14,17-diketomarcfortine D;   1- (4-morpholinosulfenyl) -15,16-dehydro-14,17-diketomas Lukhortin D;   1- (2,4-dinitrobenzenesulfenyl) -15,16-dehydro-14,17 -Diketmarkfortin D;   24-propoxy-24,25-dihydro-15,16-dehydro-14,17-diketo Marcfortine D;   1- (p-toluenesulfonyl) -15,16-dehydro-14,17-diketomark Hortin D;   1-acetyl-15,16-dehydro-14,17-diketomarcfortine D;   1-methyl-15,16-dehydro-14,17-diketomarcfortine D;   1-benzyl-15,16-dehydro-14,17-diketomarcfortine D;   1-Dimethylcarbamoyl-15,16-dehydro-14,17-diketomarkol Chin D;   1-methoxycarbonyl-15,16-dehydro-14,17-diketomarkholch D;   14α-hydroxy-14β-methyl-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-14β-methyl-17-ketomarcho Rutin A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-17-ketoxy Marcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-17-ketomer Lukhortin A;   1-cyclopropylcarbonyl-14α-hydroxy-14β-methyl-17-keto Marcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 7-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 17-ketomarkhortin A;   1-succinoyl-14α-hydroxy-14β-methyl-17-ketomarkholch A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-17- Ketomarkhortin A;   1- (2,4-dinitrobenzylsulfenyl) -14α-hydroxy-14β-me Chill-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 7-ketomarkhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-17-keto Marcfortine A;   1-Acetyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A ;   1-methyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine A ;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin A;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-17-ketomark Hortin A;   14α-hydroxy-14β-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-17-ketomarkol Chin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methyl-17- Ketomarkhortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-17-keto Marcfortine B;   1-ethyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B ;   18a-Ethyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B;   18a-benzyl-14α-hydroxy-14β-methyl-17-ketomarkholch B   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-17-ke Tomarkfortin B;   18a-allyl-14α-hydroxy-14β-methyl-17-ketomarcfortine B;   18a-Propargyl-14α-hydroxy-14β-methyl-17-ketomarkho Rutin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methyl-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-methyl-17-ketomark Hortin B;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methyl-17-keto Marcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methyl-17- Ketomarkhortin B;   24,25-Dihydro-14α-hydroxy-14β-methyl-17-ketomarkol Chin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-14β-methyl-1 7-ketomarkhortin C;   1-propionyl-14α-hydroxy-14β-methyl-17-ketomarkholch C   1-Propyl-14α-hydroxy-14β-methyl-17-ketomarcfortine C ;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine C ;   18a-Propyl-14α-hydroxy-14β-methyl-17-ketomarkholch C   18a-benzyl-14α-hydroxy-14β-methyl-17-ketomarkholch C   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-17-ke Tomarkfortin C;   18-allyl-14α-hydroxy-14β-methyl-17-ketomarcfortine C ;   18a-Propargyl-14α-hydroxy-14β-methyl-17-ketomarkho Rutin C;   1,18a-Bis-propyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin C;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin C;   14α-hydroxy-14β-methyl-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α - Hydroxy-14β-methyl-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-17-ketomarcholch A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-17-ke Tomarkfortin A;   1-palmitoyl-14α-hydroxy-14β-methyl-17-ketomarcholch D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-17-ke Tomarkfortin D;   14α-hydroxy-14β-methyl-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methyl-17-ketomarcho Rutin D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-17-ketomer Lukhortin D;   1-cyclopropylcarbonyl-14α-hydroxy-14β-methyl-17-keto Marcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 7-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 17-ketomarkhortin D;   1-succinoyl-14α-hydroxy-14β-methyl-17-ketomarkholch D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-17- Ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Chill-17-ketomarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 7-ketomarkhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-17-keto Marcfortine D;   1-Acetyl-14α-hydroxy-14β-methyl-17-ketomarcfortine D ;   1-methyl-14α-hydroxy-14β-methyl-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-14β-methyl-17-ketomarcfortine D ;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-17-ketomal Kuhortin D;   1-Methoxycarbonyl-14α-hydroxy-14β-methyl-17-ketomark Hortin D;   14-ketomarkhortin A;   1-acetoxymethyl-14-ketomarcfortine A;   1-diethoxyphosphoryl-14-ketoxoxymarkfortin A;   1-dimethylsulfamoyl-14-ketomarkfortin A;   1-cyclopropylcarbonyl-14-ketomarcfortine A;   2-bicyclo [2. 2. 1] heptanoyl-14-ketomarkfortin A;   1- (1-pyridinyl) thiocarbonyl-14-ketomarcfortine A;   1-succinoyl-14-ketomarkfortin A;   1- (4-morpholinosulphenyl) -14-ketomarcfortine A;   1- (2,4-dinitrobenzenesulfenyl) -14-ketomarcfortine A;   24-propoxy-24,25-dihydro-14-ketomarcfortine A;   1- (p-toluenesulfonyl) -14-ketomarcfortine A;   1-acetyl-14-ketomarcfortine A;   1-methyl-14-ketomarcfortine A;   1-benzyl-14-ketomarcfortine A;   1-dimethylcarbamoyl-14-ketomarcfortine A;   1-methoxycarbonyl-14-ketomarcfortine A;   14-ketomarkhortin B;   24,25-dihydro-14-ketomarcfortine B;   24-methoxy-24,25-dihydro-14-ketomarcfortine B;   1- (p-toluenesulfonyl) -14-ketomarcfortine B;   1-ethyl-14-ketomarcfortine B;   1-benzyl-14-ketomarcfortine B;   18a-ethyl-14-ketomarcfortine B;   18a-benzyl-14-ketomarcfortine B;   18a-methoxyethoxymethyl-14-ketomarcfortine B;   18a-allyl-14-ketomarcfortine B;   18a-propargyl-14-ketomarkhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14-ketomarcfortine B;   1,18a-bis-ethyl-14-ketomarcfortine B;   1,18a-bis-benzyl-14-ketomarcfortine B;   18a-Ethyl-24-methoxy-14-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-ethyl-24,25-dihydro-14-ketomarcfortine B;   24,25-dihydro-14-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -14-ketomarcfortine C;   1-propionyl-14-ketomarcfortine C;   1-propyl-14-ketomarcfortine C;   1-benzyl-14-ketomarcfortine C;   18a-propyl-14-ketomarcfortine C;   18a-benzyl-14-ketomarcfortine C;   18a-methoxyethoxymethyl-14-ketomarcfortine C;   18-allyl-14-ketomarcfortine C;   18a-propargyl-14-ketomarcfortine C;   1,18a-bis-propyl-14-ketomarcfortine C;   1,18a-bis-benzyl-14-ketomarcfortine C;   14-ketomarkhortin C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14- Ketomarkhortin A;   1-palmitoyl-14-ketomarkfortin A;   1- (4-morpholinocarbonyl) -14-ketomarcfortine A;   1-palmitoyl-14-ketomarkfortin D;   1- (4-morpholinocarbonyl) -14-ketomarkfortin D;   14-ketodroxymarcfortine D;   1-acetoxymethyl-14-ketomarcfortine D;   1-diethoxyphosphoryl-14-ketomarcfortine D;   1-dimethylsulfamoyl-14-ketomarkfortin D;   1-cyclopropylcarbonyl-14-ketomarcfortine D;   2-bicyclo [2. 2. 1] heptanoyl-14-ketomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-14-ketomarcfortine D;   1-succinoyl-14-ketomarkfortin D;   1- (4-morpholinosulfenyl) -14-ketomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14-ketomarcfortine D;   24-propoxy-24,25-dihydro-14-ketomarcfortine D;   1- (p-toluenesulfonyl) -14-ketomarcfortine D;   1-acetyl-14-ketomarcfortine D;   1-methyl-14-ketomarcfortine D;   1-benzyl-14-ketomarcfortine D;   1-dimethylcarbamoyl-14-ketomarcfortine D; or   1-Methoxycarbonyl-14-ketomarcfortine D.   16-dithio-17-ketomarcfortine A;   1-acetoxymethyl-16-dithio-17-ketomarcfortine A;   1-diethoxyphosphoryl-16-dithio-17-ketoxymarkfortin A;   1-dimethylsulfamoyl-16-dithio-17-ketomarcfortine A;   1-cyclopropylcarbonyl-16-dithio-17-ketomarcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-16-dithio-17-ketomarkholch A;   1- (1-piperidinyl) thiocarbonyl-16-dithio-17-ketomarkholch A;   1-succinoyl-16-dithio-17-ketomarcfortine A;   1- (4-morpholinosulphenyl) -16-dithio-17-ketomarcfortine A ;   1- (2,4-dinitrobenzenesulfenyl) -16-dithio-17-ketomark Hortin A;   24-propoxy-24,25-dihydro-16-dithio-17-ketomarcfortine A;   1- (p-toluenesulfonyl) -16-dithio-17-ketomarcfortine A;   1-acetyl-16-dithio-17-ketomarcfortine A;   1-methyl-16-dithio-17-ketomarcfortine A;   1-benzyl-16-dithio-17-ketomarcfortine A;   1-dimethylcarbamoyl-16-dithio-17-ketomarcfortine A;   1-methoxycarbonyl-16-dithio-17-ketomarcfortine A;   16-dithio-17-ketomarcfortine B;   24,25-dihydro-16-dithio-17-ketomarcfortine B;   24-Methoxy-24,25-dihydro-16-dithio-17-ketomarcfortine B ;   1- (p-toluenesulfonyl) -16-dithio-17-ketomarcfortine B;   1-ethyl-16-dithio-17-ketomarcfortine B;   1-benzyl-16-dithio-17-ketomarcfortine B;   18a-ethyl-16-dithio-17-ketomarcfortine B;   18a-benzyl-16-dithio-17-ketomarcfortine B;   18a-methoxyethoxymethyl-16-dithio-17-ketomarcfortine B;   18a-allyl-16-dithio-17-ketomarcfortine B;   18a-propargyl-16-dithio-17-ketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-16-dithio-17-ketomer Lukhortin B;   1,18a-bis-ethyl-16-dithio-17-ketomarcfortine B;   1,18a-bis-benzyl-16-dithio-17-ketomarcfortine B;   18a-ethyl-24-methoxy-16-dithio-17-ketomarcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-16-dithio-17-ketomarcfortine B ;   24,25-dihydro-16-dithio-17-ketomarcfortine C;   1- (p-bromobenzenesulfonyl) -16-dithio-17-ketomarcfortine C;   1-propionyl-16-dithio-17-ketomarcfortine C;   1-propyl-16-dithio-17-ketomarcfortine C;   1-benzyl-16-dithio-17-ketomarcfortine C;   18a-propyl-16-dithio-17-ketomarcfortine C;   18a-benzyl-16-dithio-17-ketomarcfortine C;   18a-methoxyethoxymethyl-16-dithio-17-ketomarcfortine C;   18-allyl-16-dithio-17-ketomarcfortine C;   18a-propargyl-16-dithio-17-ketomarcfortine C;   1,18a-bis-propyl-16-dithio-17-ketomarcfortine C;   1,18a-bis-benzyl-16-dithio-17-ketomarcfortine C;   16-dithio-17-ketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-16- Dithio-17-ketomarcfortine A;   1-palmitoyl-16-dithio-17-ketomarcfortine A;   1- (4-morpholinocarbonyl) -16-dithio-17-ketomarcfortine A;   1-palmitoyl-16-dithio-17-ketomarcfortine D;   1- (4-morpholinocarbonyl) -16-dithio-17-ketomarcfortine D;   16-dithio-17-ketodroxymarcfortine D;   1-acetoxymethyl-16-dithio-17-ketomarcfortine D;   1-diethoxyphosphoryl-16-dithio-17-ketomarcfortine D;   1-dimethylsulfamoyl-16-dithio-17-ketomarcfortine D;   1-cyclopropylcarbonyl-16-dithio-17-ketomarcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-16-dithio-17-ketomarkholch D;   1- (1-piperidinyl) thiocarbonyl-16-dithio-17-ketomarkholch D;   1-succinoyl-16-dithio-17-ketomarcfortine D;   1- (4-morpholinosulphenyl) -16-dithio-17-ketomarcfortine D ;   1- (2,4-dinitrobenzenesulfenyl) -16-dithio-17-ketomark Hortin D;   24-propoxy-24,25-dihydro-16-dithio-17-ketomarcfortine D;   1- (p-toluenesulfonyl) -16-dithio-17-ketomarcfortine D;   1-acetyl-16-dithio-17-ketomarcfortine D;   1-methyl-16-dithio-17-ketomarcfortine D;   1-benzyl-16-dithio-17-ketomarcfortine D;   1-dimethylcarbamoyl-16-dithio-17-ketomarcfortine D; or   1-Methoxycarbonyl-16-dithio-17-ketomarcfortine D.   16-thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-acetoxymethyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin A;   1-diethoxyphosphoryl-16-thiophenyl-15,16-dehydro-17-keto Ximarkfortin A;   1-dimethylsulfamoyl-16-thiophenyl-15,16-dehydro-17-ke Tomarkfortin A;   1-cyclopropylcarbonyl-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin A;   2-bicyclo [2. 2. 1] Heptanoyl-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-16-thiophenyl-15,16-dehi Doro-17-ketomarkhortin A;   1-succinoyl-16-thiophenyl-15,16-dehydro-17-ketomarkouf Rutin A;   1- (4-morpholinosulphenyl) -16-thiophenyl-15,16-dehydro- 17-ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -16-thiophenyl-15,16- Dehydro-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin A;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 -Ketmarkhortin A;   1-acetyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch A;   1-methyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch A;   1-dimethylcarbamoyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine A;   1-methoxycarbonyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin A;   16-thiophenyl-15,16-dehydro-17-ketomarcfortine B;   24,25-dihydro-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin B;   24-Methoxy-24,25-dihydro-16-thiophenyl-15,16-dehydro- 17-ketomarkhortin B;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 -Ketmarkhortin B;   1-Ethyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine B;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch B   18a-Ethyl-16-thiophenyl-15,16-dehydro-17-ketomarkol Chin B;   18a-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin B;   18a-Methoxyethoxymethyl-16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin B;   18a-allyl-16-thiophenyl-15,16-dehydro-17-ketomarkol Chin B;   18a-Propargyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-16-thiophenyl-15, 16-dehydro-17-ketomarcfortine B;   1,18a-bis-ethyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin B;   1,18a-bis-benzyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine B;   18a-Ethyl-24-methoxy-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-16-thiophenyl-15,16-dehydro- 17-ketomarkhortin B;   24,25-dihydro-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin C;   1- (p-bromobenzenesulfonyl) -16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin C;   1-propionyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin C;   1-Propyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   18a-Propyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin C;   18a-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin C;   18a-Methoxyethoxymethyl-16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin C;   18-allyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   18a-Propargyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin C;   1,18a-bis-propyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine C;   1,18a-bis-benzyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine C;   16-thiophenyl-15,16-dehydro-17-ketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-16- Thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-palmitoyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinocarbonyl) -16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin A;   1-palmitoyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinocarbonyl) -16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin D;   16-thiophenyl-15,16-dehydro-17-ketodroxymarcfortine D ;   1-acetoxymethyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin D;   1-diethoxyphosphoryl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine D;   1-dimethylsulfamoyl-16-thiophenyl-15,16-dehydro-17-ke Tomarkfortin D;   1-cyclopropylcarbonyl-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin D;   2-bicyclo [2. 2. 1] Heptanoyl-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-16-thiophenyl-15,16-dehi Doro-17-ketomarkhortin D;   1-succinoyl-16-thiophenyl-15,16-dehydro-17-ketomarkouf Rutin D;   1- (4-morpholinosulphenyl) -16-thiophenyl-15,16-dehydro- 17-ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -16-thiophenyl-15,16- Dehydro-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin D;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 -Ketmarkhortin D;   1-acetyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch D;   1-methyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch D;   1-dimethylcarbamoyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine D; or   1-methoxycarbonyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin D.   24,25-dihydro-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin C;   1- (p-bromobenzenesulfonyl) -16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin C;   1-propionyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin C;   1-Propyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   18a-Propyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin C;   18a-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkho Rutin C;   18a-Methoxyethoxymethyl-16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin C;   18-allyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch C   18a-Propargyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin C;   1,18a-bis-propyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine C;   1,18a-bis-benzyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine C;   16-thiophenyl-15,16-dehydro-17-ketomarcfortine C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-16- Thiophenyl-15,16-dehydro-17-ketomarcfortine A;   1-palmitoyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin A;   1- (4-morpholinocarbonyl) -16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin A;   1-palmitoyl-16-thiophenyl-15,16-dehydro-17-ketomarcho Rutin D;   1- (4-morpholinocarbonyl) -16-thiophenyl-15,16-dehydro-1 7-ketomarkhortin D;   16-thiophenyl-15,16-dehydro-17-ketodroxymarcfortine D ;   1-acetoxymethyl-16-thiophenyl-15,16-dehydro-17-ketomal Kuhortin D;   1-diethoxyphosphoryl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine D;   1-dimethylsulfamoyl-16-thiophenyl-15,16-dehydro-17-ke Tomarkfortin D;   1-cyclopropylcarbonyl-16-thiophenyl-15,16-dehydro-17- Ketomarkhortin D;   2-bicyclo [2. 2. 1] Heptanoyl-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-16-thiophenyl-15,16-dehi Doro-17-ketomarkhortin D;   1-succinoyl-16-thiophenyl-15,16-dehydro-17-ketomarkouf Rutin D;   1- (4-morpholinosulphenyl) -16-thiophenyl-15,16-dehydro- 17-ketomarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -16-thiophenyl-15,16- Dehydro-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-16-thiophenyl-15,16-dehyde Ro-17-ketomarkhortin D;   1- (p-toluenesulfonyl) -16-thiophenyl-15,16-dehydro-17 -Ketmarkhortin D;   1-acetyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch D;   1-methyl-16-thiophenyl-15,16-dehydro-17-ketomarcfortine D;   1-benzyl-16-thiophenyl-15,16-dehydro-17-ketomarkholch D;   1-dimethylcarbamoyl-16-thiophenyl-15,16-dehydro-17-keto Marcfortine D; or   1-methoxycarbonyl-16-thiophenyl-15,16-dehydro-17-ketoma Lukhortin D.   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkhortin A;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl- 17-Ketoxymarkfortin A;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Le-17-ketomarkhortin A;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methyl-17-ketomarcfortine A;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin A;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarkfortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methyl-17-ketomarcfortine A;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl- 15α-methyl-17-ketomarcfortine A;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin A;   1-acetyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin A;   1-methyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomal Kuhortin A;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin A;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin A;   1-methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methyl-1 7-ketomarkhortin A;   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methyl-17- Ketomarkhortin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarcfortine B;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin B;   1-Ethyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomal Kuhortin B;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin B;   18a-Ethyl-14α-hydroxy-14β-methyl-15α-methyl-17-keto Marcfortine B;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin B;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarcfortine B;   18a-allyl-14α-hydroxy-14β-methyl-15α-methyl-17-keto Marcfortine B;   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkhortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-14 β-methyl-15α-methyl-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-14β-methyl-15α-methyl-1 7-ketomarkhortin B;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin B;   18a-Ethyl-24-methoxy-14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-14β-methyl-15α-methyl-17- Ketomarkhortin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine C;   1-propionyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin C;   1-Propyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomer Lukhortin C;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin C;   18a-Propyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin C;   18a-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin C;   18a-Methoxyethoxymethyl-14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarcfortine C;   18-allyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin C;   18a-Propargyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkfortin C;   1,18a-bis-propyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin C;   1,18a-bis-benzyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin C;   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin A;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarkfortin A;   1-palmitoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin D;   1- (4-morpholinocarbonyl) -14α-hydroxy-14β-methyl-15α- Methyl-17-ketomarkfortin D;   14α-hydroxy-14β-methyl-15α-methyl-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-14β-methyl-15α-methyl-17 -Ketmarkhortin D;   1-diethoxyphosphoryl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin D;   1-Dimethylsulfamoyl-14α-hydroxy-14β-methyl-15α-meth Le-17-ketomarkhortin D;   1-Cyclopropylcarbonyl-14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-14β-methyl- 15α-methyl-17-ketomarcfortine D;   1-succinoyl-14α-hydroxy-14β-methyl-15α-methyl-17-ke Tomarkfortin D;   1- (4-morpholinosulphenyl) -14α-hydroxy-14β-methyl-15 α-methyl-17-ketomarcfortine D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-14β-me Tyl-15α-methyl-17-ketomarcfortine D;   24-propoxy-24,25-dihydro-14α-hydroxy-14β-methyl-1 5α-methyl-17-ketomarcfortine D;   1- (p-toluenesulfonyl) -14α-hydroxy-14β-methyl-15α-me Chill-17-ketomarkfortin D;   1-acetyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin D;   1-methyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketomal Kuhortin D;   1-benzyl-14α-hydroxy-14β-methyl-15α-methyl-17-ketom Lukhortin D;   1-Dimethylcarbamoyl-14α-hydroxy-14β-methyl-15α-methyl- 17-ketomarkhortin D;   1-methoxycarbonyl-14α-hydroxy-14β-methyl-15α-methyl-1 7-ketomarkhortin D;   14α-hydroxy-15α-methyl-17-ketomarcfortine A;   1-acetoxymethyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin A;   1-diethoxyphosphoryl-14α-hydroxy-15α-methyl-17-ketoxy Marcfortine A;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methyl-17-ketomer Lukhortin A;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methyl-17-keto Marcfortine A;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methyl-1 7-ketomarkhortin A;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methyl- 17-ketomarkhortin A;   1-succinoyl-14α-hydroxy-15α-methyl-17-ketomarcholch A;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methyl-17- Ketomarkhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Chill-17-ketomarkfortin A;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methyl-1 7-ketomarkhortin A;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methyl-17-keto Marcfortine A;   1-Acetyl-14α-hydroxy-15α-methyl-17-ketomarcfortine A ;   1-methyl-14α-hydroxy-15α-methyl-17-ketomarcfortine A;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine A ;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin A;   1-methoxycarbonyl-14α-hydroxy-15α-methyl-17-ketomark Hortin A;   14α-hydroxy-15α-methyl-17-ketomarcfortine B;   24,25-Dihydro-14α-hydroxy-15α-methyl-17-ketomarkol Chin B;   24-Methoxy-24,25-dihydro-14α-hydroxy-15α-methyl-17- Ketomarkhortin B;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methyl-17-keto Marcfortine B;   1-ethyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B ;   18a-Ethyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B;   18a-benzyl-14α-hydroxy-15α-methyl-17-ketomarkholch B   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methyl-17-ke Tomarkfortin B;   18a-allyl-14α-hydroxy-15α-methyl-17-ketomarcfortine B;   18a-Propargyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin B;   18a-Ethyl-24-methoxy-24,25-dihydro-14α-hydroxy-15 α-methyl-17-ketomarcfortine B;   1,18a-bis-ethyl-14α-hydroxy-15α-methyl-17-ketomark Hortin B;   1,18a-bis-benzyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin B;   18a-Ethyl-24-methoxy-14α-hydroxy-15α-methyl-17-keto Marcfortine B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14α-hydroxy-15α-methyl-17- Ketomarkhortin B;   24,25-Dihydro-14α-hydroxy-15α-methyl-17-ketomarkol Chin C;   1- (p-bromobenzenesulfonyl) -14α-hydroxy-15α-methyl-1 7-ketomarkhortin C;   1-propionyl-14α-hydroxy-15α-methyl-17-ketomarcholch C   1-Propyl-14α-hydroxy-15α-methyl-17-ketomarcfortine C ;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine C ;   18a-Propyl-14α-hydroxy-15α-methyl-17-ketomarkholch C   18a-Propyl-14α-hydroxy-15α-methyl-17-ketomarkholch C   18a-benzyl-14α-hydroxy-15α-methyl-17-ketomarkholch C   18a-Methoxyethoxymethyl-14α-hydroxy-15α-methyl-17-ke Tomarkfortin C;   18-allyl-14α-hydroxy-15α-methyl-17-ketomarcfortine C ;   18a-Propargyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin C;   1,18a-Bis-propyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin C;   1,18a-bis-benzyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin C;   14α-hydroxy-15α-methyl-17-ketomarcfortine C;   1- (4-carboethoxy-1,3-thiazolidinin-3-yl) carbonyl-14α -Hydroxy-15α-methyl-17-ketomarcfortine A;   1-palmitoyl-14α-hydroxy-15α-methyl-17-ketomarkholch A;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methyl-17-ke Tomarkfortin A;   1-palmitoyl-14α-hydroxy-15α-methyl-17-ketomarkholch D;   1- (4-morpholinocarbonyl) -14α-hydroxy-15α-methyl-17-ke Tomarkfortin D;   14α-hydroxy-15α-methyl-17-ketomarcfortine D;   1-acetoxymethyl-14α-hydroxy-15α-methyl-17-ketomarcho Rutin D;   1-diethoxyphosphoryl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin D;   1-Dimethylsulfamoyl-14α-hydroxy-15α-methyl-17-ketomer Lukhortin D;   1-Cyclopropylcarbonyl-14α-hydroxy-15α-methyl-17-keto Marcfortine D;   2-bicyclo [2. 2. 1] Heptanoyl-14α-hydroxy-15α-methyl- 17-ketomarkhortin D;   1- (1-piperidinyl) thiocarbonyl-14α-hydroxy-15α-methyl- 17-ketomarkhortin D;   1-succinoyl-14α-hydroxy-15α-methyl-17-ketomarcholch D;   1- (4-morpholinosulphenyl) -14α-hydroxy-15α-methyl-17 -Ketmarkhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14α-hydroxy-15α-me Chill-17-ketomarkfortin D;   24-propoxy-24,25-dihydro-14α-hydroxy-15α-methyl-1 7-ketomarkhortin D;   1- (p-toluenesulfonyl) -14α-hydroxy-15α-methyl-17-keto Marcfortine D;   1-acetyl-14α-hydroxy-15α-methyl-17-ketomarcfortine D ;   1-methyl-14α-hydroxy-15α-methyl-17-ketomarcfortine D;   1-benzyl-14α-hydroxy-15α-methyl-17-ketomarcfortine D ;   1-Dimethylcarbamoyl-14α-hydroxy-15α-methyl-17-ketomal Kuhortin D;   1-methoxycarbonyl-14α-hydroxy-15α-methyl-17-ketomark Hortin D;   15α-methyl-14,17-diketomarkfortin A;   1-acetoxymethyl-15α-methyl-14,17-diketomarkfortin A;   1-diethoxyphosphoryl-15α-methyl-14,17-diketoxymarkholch A;   1-Dimethylsulfamoyl-15α-methyl-14,17-diketomarcfortine A;   1-Cyclopropylcarbonyl-15α-methyl-14,17-diketomarkholch A;   2-bicyclo [2. 2. 1] Heptanoyl-15α-methyl-14,17-diketomal Kuhortin A;   1- (1-piperidinyl) thiocarbonyl-15α-methyl-14,17-diketomer Lukhortin A;   1-succinoyl-15α-methyl-14,17-diketomarkfortin A;   1- (4-morpholinosulfenyl) -15α-methyl-14,17-diketomark Hortin A;   1- (2,4-dinitrobenzenesulfenyl) -15α-methyl-14,17-dike Tomarkfortin A;   24-propoxy-24,25-dihydro-15α-methyl-14,17-diketomal Kuhortin A;   1- (p-toluenesulfonyl) -15α-methyl-14,17-diketomarkol Chin A;   1-acetyl-15α-methyl-14,17-diketomarcfortine A;   1-methyl-15α-methyl-14,17-diketomarcfortine A;   1-benzyl-15α-methyl-14,17-diketomarcfortine A;   1-Dimethylcarbamoyl-15α-methyl-14,17-diketomarcfortine A ;   1-methoxycarbonyl-15α-methyl-14,17-diketomarcfortine A;   15α-methyl-14,17-diketomarcfortine B;   24,25-dihydro-15α-methyl-14,17-diketomarcfortine B;   24-Methoxy-24,25-dihydro-15α-methyl-14,17-diketomark Hortin B;   1- (p-toluenesulfonyl) -15α-methyl-14,17-diketomarkol Chin B;   1-ethyl-15α-methyl-14,17-diketomarcfortine B;   1-benzyl-15α-methyl-14,17-diketomarcfortine B;   18a-Ethyl-15α-methyl-14,17-diketomarcfortine B;   18a-benzyl-15α-methyl-14,17-diketomarcfortine B;   18a-Methoxyethoxymethyl-15α-methyl-14,17-diketomarkol Chin B;   18a-allyl-15α-methyl-14,17-diketomarcfortine B;   18a-propargyl-15α-methyl-14,17-diketomarkfortin B;   18a-Ethyl-24-methoxy-24,25-dihydro-15α-methyl-14,17 -Diketmarkfortin B;   1,18a-bis-ethyl-15α-methyl-14,17-diketomarcfortine B;   1,18a-bis-benzyl-15α-methyl-14,17-diketomarcfortine B ;   18a-Ethyl-24-methoxy-15α-methyl-14,17-diketomarkholch B   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-15α-methyl-14,17-diketomark Hortin B;   24,25-dihydro-15α-methyl-14,17-diketomarcfortine C;   1- (p-bromobenzenesulfonyl) -15α-methyl-14,17-diketomal Kuhortin C;   1-propionyl-15α-methyl-14,17-diketomarcfortine C;   1-propyl-15α-methyl-14,17-diketomarkfortin C;   1-benzyl-15α-methyl-14,17-diketomarcfortine C;   18a-Propyl-15α-methyl-14,17-diketomarcfortine C;   18a-benzyl-15α-methyl-14,17-diketomarcfortine C;   18a-Methoxyethoxymethyl-15α-methyl-14,17-diketomarkol Chin C;   18-allyl-15α-methyl-14,17-diketomarcfortine C;   18a-propargyl-15α-methyl-14,17-diketomarcfortine C;   1,18a-bis-propyl-15α-methyl-14,17-diketomarcfortine C ;   1,18a-bis-benzyl-15α-methyl-14,17-diketomarcfortine C ;   15α-methyl-14,17-diketomarkfortin C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-15 α-methyl-14,17-diketomarcfortine A;   1-palmitoyl-15α-methyl-14,17-diketomarkfortin A;   1- (4-morpholinocarbonyl) -15α-methyl-14,17-diketomarko Rutin A;   1-palmitoyl-15α-methyl-14,17-diketomarkfortin D;   1- (4-morpholinocarbonyl) -15α-methyl-14,17-diketomarko Rutin D;   15α-methyl-14,17-diketomarcfortine D;   1-acetoxymethyl-15α-methyl-14,17-diketomarkfortin D;   1-diethoxyphosphoryl-15α-methyl-14,17-diketomarcfortine D ;   1-Dimethylsulfamoyl-15α-methyl-14,17-diketomarcfortine D;   1-Cyclopropylcarbonyl-15α-methyl-14,17-diketomarkholch D;   2-bicyclo [2. 2. 1] Heptanoyl-15α-methyl-14,17-diketomal Kuhortin D;   1- (1-piperidinyl) thiocarbonyl-15α-methyl-14,17-diketomer Lukhortin D;   1-succinoyl-15α-methyl-14,17-diketomarkfortin D;   1- (4-morpholinosulphenyl) -15α-methyl-14,17-diketomark Hortin D;   1- (2,4-dinitrobenzenesulfenyl) -15α-methyl-14,17-dike To Marcfortine D;   24-propoxy-24,25-dihydro-15α-methyl-14,17-diketomal Kuhortin D;   1- (p-toluenesulfonyl) -15α-methyl-14,17-diketomarkol Chin D;   1-acetyl-15α-methyl-14,17-diketomarcfortine D;   1-methyl-15α-methyl-14,17-diketomarcfortine D;   1-benzyl-15α-methyl-14,17-diketomarcfortine D;   1-Dimethylcarbamoyl-15α-methyl-14,17-diketomarkfortin D ;   1-methoxycarbonyl-15α-methyl-14,17-diketomarcfortine D;   14,15-dehydro-16,17-diketomarcfortine A;   1-acetoxymethyl-14,15-dehydro-16,17-diketomarcfortine A;   1-diethoxyphosphoryl-14,15-dehydro-16,17-diketoxymark Hortin A;   1-Dimethylsulfamoyl-14,15-dehydro-16,17-diketomarko Rutin A;   1-cyclopropylcarbonyl-14,15-dehydro-16,17-diketomark Hortin A;   2-bicyclo [2. 2. 1] Heptanoyl-14,15-dehydro-16,17-dike Tomarkfortin A;   1- (1-piperidinyl) thiocarbonyl-14,15-dehydro-16,17-dike Tomarkfortin A;   1-succinoyl-14,15-dehydro-16,17-diketomarcfortine A;   1- (4-morpholinosulfenyl) -14,15-dehydro-16,17-diketomas Lukhortin A;   1- (2,4-dinitrobenzenesulfenyl) -14,15-dehydro-16,17 - Diketmarkfortin A;   24-propoxy-24,25-dihydro-14,15-dehydro-16,17-diketo Marcfortine A;   1- (p-toluenesulfonyl) -14,15-dehydro-16,17-diketomark Hortin A;   1-acetyl-14,15-dehydro-16,17-diketomarcfortine A;   1-methyl-14,15-dehydro-16,17-diketomarcfortine A;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine A;   1-dimethylcarbamoyl-14,15-dehydro-16,17-diketomarkol Chin A;   1-Methoxycarbonyl-14,15-dehydro-16,17-diketomarkholch A;   14,15α-dehydro-16,17-diketomarcfortine B;   24,25-dihydro-14,15-dehydro-16,17-diketomarcfortine B ;   24-methoxy-24,25-dihydro-14,15-dehydro-16,17-diketomers Lukhortin B;   1- (p-toluenesulfonyl) -14,15-dehydro-16,17-diketomark Hortin B;   1-ethyl-14,15-dehydro-16,17-diketomarcfortine B;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Ethyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-benzyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Methoxyethoxymethyl-14,15-dehydro-16,17-diketomal Kuhortin B;   18a-allyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Propargyl-14,15-dehydro-16,17-diketomarcfortine B;   18a-Ethyl-24-methoxy-24,25-dihydro-14,15-dehydro-16 , 17-Diketomarkfortin B;   1,18a-bis-ethyl-14,15-dehydro-16,17-diketomarkholch B   1,18a-bis-benzyl-14,15-dehydro-16,17-diketomarkol Chin B;   18a-Ethyl-24-methoxy-14,15-dehydro-16,17-diketomark Hortin B;   1- (2,4-dinitrobenzenesulfonyl) -18a-ethyl-24-methoxy-2 4,25-dihydro-14α-hydroxymarcfortine B;   18a-Ethyl-24,25-dihydro-14,15-dehydro-16,17-diketomas Lukhortin B;   24,25-dihydro-14,15-dehydro-16,17-diketomarcfortine C ;   1- (p-bromobenzenesulfonyl) -14,15-dehydro-16,17-diketo Marcfortine C;   1-propionyl-14,15-dehydro-16,17-diketomarcfortine C;   1-propyl-14,15-dehydro-16,17-diketomarcfortine C;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-propyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-benzyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-Methoxyethoxymethyl-14,15-dehydro-16,17-diketomal Kuhortin C;   18-allyl-14,15-dehydro-16,17-diketomarcfortine C;   18a-Propargyl-14,15-dehydro-16,17-diketomarcfortine C;   1,18a-bis-propyl-14,15-dehydro-16,17-diketomarkol Chin C;   1,18a-bis-benzyl-14,15-dehydro-16,17-diketomarkol Chin C;   14,15-dehydro-16,17-diketomarkfortin C;   1- (4-carbethoxy-1,3-thiazolidinin-3-yl) carbonyl-14, 15-dehydro-16,17-diketomarcfortine A;   1-palmitoyl-14,15-dehydro-16,17-diketomarcfortine A;   1- (4-morpholinocarbonyl) -14,15-dehydro-16,17-diketomal Kuhortin A;   1-palmitoyl-14,15-dehydro-16,17-diketomarcfortine D;   1- (4-morpholinocarbonyl) -14,15-dehydro-16,17-diketomal Kuhortin D;   14,15-dehydro-16,17-diketomarkfortin D;   1-acetoxymethyl-14,15-dehydro-16,17-diketomarcfortine D;   1-diethoxyphosphoryl-14,15-dehydro-16,17-diketomarkol Chin D;   1-Dimethylsulfamoyl-14,15-dehydro-16,17-diketomarko Rutin D;   1-cyclopropylcarbonyl-14,15-dehydro-16,17-diketomark Hortin D;   2-bicyclo [2. 2. 1] Heptanoyl-14,15-dehydro-16,17-dike Tomarkfortin D;   1- (1-piperidinyl) thiocarbonyl-14,15-dehydro-16,17-dike Tomarkfortin D;   1-succinoyl-14,15-dehydro-16,17-diketomarcfortine D;   1- (4-morpholinosulfenyl) -14,15-dehydro-16,17-diketomas Lukhortin D;   1- (2,4-dinitrobenzenesulfenyl) -14,15-dehydro-16,17 - Diketmarkfortin D;   24-propoxy-24,25-dihydro-14,15-dehydro-16,17-diketo Marcfortine D;   1- (p-toluenesulfonyl) -14,15-dehydro-16,17-diketomark Hortin D;   1-acetyl-14,15-dehydro-16,17-diketomarcfortine D;   1-methyl-14,15-dehydro-16,17-diketomarcfortine D;   1-benzyl-14,15-dehydro-16,17-diketomarcfortine D;   1-dimethylcarbamoyl-14,15-dehydro-16,17-diketomarkol Chin D;   1-Methoxycarbonyl-14,15-dehydro-16,17-diketomarkholch D A compound selected from the group consisting of: 17． The compound according to claim 1, wherein Z is an oxygen atom. 18. R_{twenty four}And R_{twenty five}Is hydrogen; R_18aIs hydrogen, C₁-C₇Alkyl, C₁-C₈Arco Xymethyl, C₂-C₈Alkenyl or benzyl; Y is a bond; dashed line is charcoal 18. A compound according to claim 17, which represents a double bond between elements 24 and 25. 19. The compound according to claim 1, wherein Z is a sulfur atom. 20. R_{twenty four}And R_{twenty five}Is hydrogen; R_18aIs hydrogen, C₁-C₇Alkyl, C₁-C₈Arco Xymethyl, C₂-C₈Alkenyl or benzyl; Y is a bond; dashed line is charcoal 20. A compound according to claim 19 which represents the double bond between elements 24 and 25.