JPH08336549A - Container for artificial organs using apatite - Google Patents

Abstract

PURPOSE: To easily treat the organs of the lesion part by using a material having a function to reproduce autotissues. CONSTITUTION: At least the inside walls of this container for artificial organs are composed of the material consisting essentially of apatite. A material compounded with an org. material, such as collagen, under a condition of >=30wt.% of the apatite content is also usable as the material for the inside walls of the vessel. As a result, the container is used as the container for the artificial organs for freshly generating the organ tissues which are the autotissues in the treatment of the disease caused by the lesion of the organ tissues.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a container for artificial organ used as an implant material to be embedded in the human body or animal body.

[0002]

2. Description of the Related Art With the development of treatment technology, various treatment instruments and equipment have been developed and used. For example, when the liver, adrenal gland, spleen, and other internal organs that control detoxification and endocrine of body fluid become dysfunctional due to lesions, a substitute that can replace the internal organs is required. Attempts have been made to use various kinds of plastics, metals, glass, etc. as a material forming the inner wall of the container with which these tissues come into direct contact when a part of the organ tissues is transplanted or proliferated. Further, in order to improve biocompatibility, it is also considered to apply chemical employment to the material surface. Recently, it has been reported that when the inner wall of the container is coated with collagen, the tissue is easily activated.

[0003]

As described above, various materials have been developed as materials for internal organs, but they are far from practical use and are still at the basic research stage. Therefore, it is the current situation that most of them have to rely on organ transplantation among individuals with matched blood types. However, in organ transplants between individuals,
Compatibility issues are unavoidable, and finding the person to donate an organ is not easy. The present invention has been devised to solve such a problem, and by using apatite as a material capable of accommodating and proliferating organ tissues, the treatment of diseases caused by malfunction of internal organs. The purpose is to facilitate.

[0004]

In order to achieve the object, the container for artificial organs of the present invention is a container for containing the tissue of an organ, and at least the inner wall of the container is made of a material whose main component is apatite. It is characterized by A material in which an organic substance such as collagen is mixed under the condition that the apatite content is 30% by weight or more can be used as the material of the inner wall of the container.

[0005]

The present inventors have conducted various investigations and researches on materials that can be used as implant materials. In the process,
It was found that apatite expresses a unique function.
That is, a part of the tissues such as liver, adrenal gland, spleen, etc. is cut out from the experimental animal, placed in a small container made of hydroxyapatite, and the small container is connected to the blood vessel of the experimental animal so that blood flow will wash the tissue in the container , And investigated and studied the effect of apatite. As a result, it was observed that each tissue was growing. As a result of repeated experiments based on this finding, it was found that it is important to grow a visceral tissue by using a molded body containing apatite as the main component on the inner wall that directly contacts the visceral tissue. It is speculated that this phenomenon is derived from the fact that undifferentiated cells newly create organ tissue in the environment inside the apatite porous body in the process of healing the tissue damaged by implant surgery.

When an inner wall containing an organic substance such as collagen in addition to apatite was used, each visceral tissue was well grown. This indicates that the growth of the visceral tissue by an organic substance such as collagen is promoted by apatite. However, it was difficult for the tissue to grow on the inner wall made of a material without apatite. The action of such apatite is effective when forming the inner wall of the container with a material containing 30% by weight or more of apatite. It is a necessary condition for tissue growth to connect a blood vessel to the container containing the visceral tissue and fill the container with a rich blood flow. In this respect, an apatite porous body having a through hole of about 2 mm corresponding to the diameter of a medium-sized stem blood vessel and 10 μm or more corresponding to the pore diameter of a capillary is preferable. When these conditions are satisfied, the organ tissue piece actively activates and proliferates in the bloodstream and grows to fill the space inside the container.

[0007]

[Examples] A calcium hydroxide suspension was stirred at room temperature, and an aqueous phosphoric acid solution was injected thereinto to synthesize stoichiometric apatite powder. The crystal grain size was 100 nm in length and 20 nm in thickness. This powder was sealed in a metal sealed tube and evacuated. By holding this sealed tube at 700 ° C. and 600 MPa for 2 hours, an apatite sintered body was manufactured. The average crystal grain size of the obtained sintered body was about 30 nm. Thus, a rectangular hydroxyapatite sintered body having a length of 50 mm, a width of 40 mm and a thickness of 8 mm was obtained. A comb-shaped flow channel having an inner diameter of 2 to 5 mm was formed inside the apatite sintered body, and a metal titanium tube was fixed to the end of the flow channel to serve as a blood flow outlet and an inlet. A small cavity was provided in a part of the flow path, and a rice grain-sized liver piece extracted from an adult dog was planted. The hydroxyapatite sintered body container thus configured was fixed to the thigh of the adult dog used for extracting the liver piece. Then, incisions of the blood vessels obtained by cutting the femoral artery were connected to both ends of each metallic titanium tube so that blood flow was maintained in the liver tissue pieces in the container. After closing the wound on the adult dog, the dog was kept in a healthy condition. After the lapse of 8 weeks, the contents were extracted and the inside of the container was inspected. As a result of microscopic observation, it was confirmed that the entire flow path in the container was filled with liver tissue, and the regenerated vascular tissue penetrated therein.

[0008]

As described above, the container for artificial organs of the present invention utilizes the function of apatite for producing and growing organ tissues and is a self-organized tissue for treating diseases caused by lesions of organ tissues. Used as an implant material for artificial organs that newly generate organ tissues. Therefore, it is possible to avoid the difficult work of finding a blood type matching person in order to transplant an organ of a different individual, thereby facilitating disease treatment.

Claims (2)

[Claims] 1. A container for accommodating tissue of an organ, wherein at least the inner wall of the container is made of a material whose main component is apatite. 2. A container for artificial organs, wherein the inner wall of the container according to claim 1 is made of apatite mixed with an organic substance such as collagen, and the apatite content is 30% by weight or more.