JPH08317948A - Skin burn healing poultice - Google Patents

Abstract

PURPOSE: To provide a skin burn healing poultice which exhibits excellent effect in initial treatment of skin burn by enclosing a heat insulating agent in a supporting body and making a glass transition temperature of the adhesive agent to a prescribed temperature range. CONSTITUTION: An adhesive agent layer composed of an adhesive agent and medicine is disposed on one side of supporting body, an heat insulating agent is enclosed in the supporting body, and the glass transition temperature of the adhesive agent is made to be -60 to -100 deg.C. The supporting body uses materials having strength, flexibility and adhesiveness sufficient to contain the heat insulating agent, including such resin film as soft polyvinyl chloride film for example. Methods to enclose the heat insulating agent in the supporting body may include a method to wrap the heat insulating material into a supporting body formed in the shape of a bag. The heat insulating agent has no special limitation as long as it has softness or fluidity suitable for affixing onto skin, and may include oil gel. Adhesive agents with a glass transition temperature in a range of -60 to -100 deg.C would include adhesiveness doner resin, such as natural coumarone-indene resin.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a patch for treating burns.

[0002]

2. Description of the Related Art Generally, in the treatment of burns, cooling with running water is frequently performed as an initial treatment.
By such treatment, necrosis and edema of the skin tissue can be minimized, and the occurrence of keloids and the like afterwards can be suppressed. However, the cooling of the affected area by running water requires immersion in running water or contact with running water, which poses a problem that the behavior and activities of the human body are disturbed. In addition, the method of cooling the affected area with ice or an ice sac also has a problem that the behavior and activity of the human body are disturbed, as in the case of cooling with water.

[0003]

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and an object thereof is to provide a patch for the treatment of burns which exhibits an excellent effect in the initial treatment of burns. is there.

[0004]

Means for Solving the Problems The patch for treating burns of the present invention is provided with a pressure-sensitive adhesive layer comprising a pressure-sensitive adhesive and a drug on one surface of a support, and a cold-retaining agent is enclosed in the support, The pressure-sensitive adhesive has a glass transition point of −60 to −100 ° C.

As the support used in the present invention, a material having sufficient strength, flexibility and adhesiveness for enclosing a cold insulating agent described later is used, and examples thereof include soft vinyl chloride resin and polyurethane. A resin film may be used. A cooling agent is enclosed in the support, and examples of the method for enclosing the cooling agent include a method of wrapping the cooling agent in a support formed in a bag shape.

The cold-retaining agent is not particularly limited as long as it has flexibility and fluidity suitable for application to the skin, and examples thereof include oily gel. As a cooling agent using such an oily gel, for example, "Aqua U Ace" manufactured by Sekisui Plastics Co., Ltd. is preferably used.
The amount of the cold-retaining agent enclosed in the support is insufficient to provide sufficient cooling performance as the treatment effect becomes insufficient, and the application site is limited due to lack of flexibility as the thickness increases,
It is preferable to enclose the support so that the thickness of the support is 0.5 to 3 mm.

When the glass transition point of the pressure-sensitive adhesive used in the present invention is low, the cohesive force is insufficient and adhesive residue easily occurs,
If it becomes higher, sufficient adhesive force cannot be obtained and peeling easily occurs.

As the pressure-sensitive adhesive having the above glass transition point range,
For example, natural rubber includes tackifier resins such as coumarone / indene resin; polyterpene resin such as piccolite and YS resin.

Additives may be added in order to adjust the adhesive strength of the adhesive layer and increase the transdermal absorption of the drug. Examples of such additives include N-lauroyl sarcosine, lauric acid diethanolamide,
Surfactants such as sodium polyoxyethylene lauryl ether phosphate; fatty acid esters such as isopropyl myristate and isopropyl palmitate; organic acids such as lactic acid and oleic acid.

The pressure-sensitive adhesive layer may contain a drug usually used for burn treatment. Examples of the drug include antibiotics for preventing purulence; corticosteroids for anti-inflammatory; vitamin C for assisting skin function activation,
Examples thereof include vitamins such as vitamin E, and shikon extract which is said to have a tissue activating function.

The patch for treating burns of the present invention is applied to the affected area after cooling in a refrigerator or the like before use.

[0012]

Embodiments of the present invention will be described below. [Preparation of rubber-based pressure-sensitive adhesive] 85 parts by weight of natural rubber, 15 parts by weight of YS resin ("P-100" manufactured by Yasuhara Yushi Co., Ltd.), and tetrahydrofuran were placed in a separable flask so that the solid concentration was 15% by weight. The mixture was stirred all day and night to prepare a rubber adhesive. The glass transition point of this rubber-based pressure-sensitive adhesive was -70 ° C when measured by viscoelastic spectrum.

Example 1 The above-mentioned rubber-based pressure-sensitive adhesive solution was applied onto a silicon-treated polyethylene terephthalate film having a thickness of 35 μm and dried, and the thickness after drying was 63 μm.
m adhesive layer was provided. Next, this pressure-sensitive adhesive layer is laminated on a soft vinyl chloride resin film (“Esmedica” manufactured by Sekisui Chemical Co., Ltd.) support having a thickness of 2 mm × 10 cm × 10 cm and a cold-retaining agent enclosed, and applied for burn treatment. I got an agent.

[Preparation of acrylic pressure-sensitive adhesive] 10 mol% of dodecyl methacrylate, 10 mol% of 2-ethylhexyl acrylate, and 2-ethylhexyl methacrylate 8
0 mol% was charged into a separable flask, and ethyl acetate was gradually added so that the solid content concentration at the end of the polymerization was 50% by weight. This solution was heated to 70 ° C. under a nitrogen atmosphere,
Polymerization was carried out for 40 hours while adding ethyl acetate solution of lauroyl peroxide, which is a polymerization initiator, little by little every 2 hours to obtain an acrylic pressure-sensitive adhesive solution. The glass transition point of this acrylic pressure-sensitive adhesive was 15 ° C. when measured by viscoelastic spectrum.

Comparative Example 1 A patch for treating burns was obtained in the same manner as in Example 1 except that the above acrylic adhesive was used instead of the rubber adhesive.

With respect to the patches for treating burns obtained in the above Examples and Comparative Examples, the healing effect of burns was evaluated by the following method. Rats (Wister strain) are shaved and have an inner diameter of 1
After pressing a glass cell containing 0 mm of 90 ° C hot water for 10 seconds, the patch for burn treatment cooled in a refrigerator was immediately applied for 1 hour, and the healing effect after 1 week was judged according to the following criteria. The results are shown in Table 1. 4 points: Almost no burn scar was observed. 3 points: A very slight burn scar that was barely discernible was recognized. 2 points: Clearly a burn scar was observed. 1 point: Tissue necrosis was observed. 0 points: Died from burns. The same evaluation is repeated 10 times and the total score is 10
The values divided by are shown in the table.

[0017]

[0018]

EFFECTS OF THE INVENTION The composition of the patch for treating burns of the present invention is as described above, and is excellent in adhesiveness and excellent in treatment of burns due to the cooling effect of the cooling agent enclosed in the support. It does not interfere with the behavior and activities of the human body.

Claims (1)

[Claims] 1. A patch having a pressure-sensitive adhesive layer comprising a pressure-sensitive adhesive and a drug on one surface of a support, wherein a cold-retaining agent is enclosed in the support, and the glass transition point of the pressure-sensitive adhesive is -60 to. -1
A patch for treating burns, characterized in that the temperature is 00 ° C.