JPH08309157A - Method and apparatus for manufacturing hollow fiber membrane type blood treatment apparatus - Google Patents

Abstract

PURPOSE: To enable mechanization and to manufacture a simple and stable treatment apparatus by a method in which a hollow fiber membrane bundle is inserted into a vacuum resistant packaging material, and the packaging material is deaerated, brought into close contact with the bundle, set in a cylindrical housing, and then extracted. CONSTITUTION: Both ends of a hollow fiber membrane bundle 101 are bound with tapes 102, 103, and the bundle 101 is gripped by a hollow fiber membrane bundle gripping part 104. Besides, a packaging material 108 such as polyethylene is set in packaging material supporting parts 107, 110 and inflated by introducing sterilized air. The gripping part 104 is moved, the bundle 101 is inserted into the packaging material 108, the gripping part 104 is moved upward, an insertion port lid 109 is closed, and a deaerator 116 is operated to reduce pressure. The packaging material 108 is brought into close contact with the bundle 101, and the membranes are also contacted closely with each other to tighten the bundle 101. The packaging material 108 is set in a cylindrical housing, cut off between the upper end of the bundle 101 and a supporting part, and then extracted.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method and an apparatus for manufacturing a hollow fiber membrane-type blood treatment apparatus such as artificial dialysis, plasma separation and artificial oxygen exchanger used for medical purposes. More specifically, the present invention relates to a method and apparatus for inserting a hollow fiber membrane used in a hollow fiber membrane blood processing apparatus into a cylindrical housing.

[0002]

2. Description of the Related Art A blood processing apparatus used for medical purposes is used for an artificial dialyzer used for treating renal failure patients, a plasma separator used for treating systemic lupus erythematosus, macroglobulinemia and the like, and used for open heart surgery. There is an artificial oxygen exchanger (artificial lung). The artificial dialyzer is used for removing urea and the like accumulated in blood, and is used by flowing blood into the hollow fiber membrane lumen and circulating the dialysate outside the hollow fiber membrane. A plasma separator is a treatment that causes blood to flow through the hollow fiber membrane lumen, separates plasma containing the etiological agent that passes through the hollow fiber membrane from blood, and replaces it with fresh frozen plasma to remove the etiological agent from the blood. Is the law. An oxygen-permeable hollow fiber membrane is used for the artificial lung, and blood is allowed to flow through the hollow fiber membrane lumen and a gas containing oxygen is allowed to flow outside the hollow fiber membrane. In either method, a large number of hollow fiber membranes are used in order to efficiently perform substance exchange, and only one of the hollow fiber membranes is damaged, and blood and the outer fluid of the hollow fiber membranes and the outside air come into contact with each other. , The function as a therapeutic tool is impaired.

Conventionally, in the manufacture of a hollow fiber membrane type blood processing apparatus, the hollow fiber membrane is loaded into a cylindrical housing by the following steps.

(1) A bundle forming step of collecting a predetermined number of hollow fiber membranes to form a bundle of hollow fiber membranes (2) A loading step of loading the hollow fiber membrane bundles into a cylindrical housing. Careful operation is required because it is necessary to densely load the hollow fiber membrane into the tubular housing without damaging or cutting the yarn.
Further, in order to improve the performance of blood treatment, it is required to densely fill the housing with a hollow fiber membrane. Several ideas have been reported for the purpose of improving the efficiency and stabilization of this process work in order to improve the productivity of products.

According to Japanese Patent Laid-Open No. 60-54711,
By hand, a sheet wider than the outer circumference of the hollow fiber membrane bundle is wound, the hollow fiber membrane is tightened in the radial direction, and it is loaded into the cylindrical housing as it is, and then the sheet sandwiched between the housing and the hollow fiber membrane is removed. Is disclosed.
Further, according to JP-A-60-80463, a hollow fiber membrane bundle is positioned at one end of a cylindrical housing without a hollow fiber membrane protective packaging material, sucked from the other end of the housing, and loaded into the cylindrical housing. The method of doing is proposed. In these methods, the hollow fiber membrane was highly likely to be deformed or damaged due to tightening or contact with the housing.

Further, Japanese Patent Application Laid-Open No. 5-305220 proposes a method of squeezing a hollow fiber membrane bundle from the outside through a hollow fiber membrane protective packaging material by a thin plate interlocking with a wire and pushing it into a tubular housing. ing. With this, it is possible to automate the work, but since the compressive force in the radial direction of the hollow fiber membrane still acts from the outside,
The problem of deformation of the hollow fiber membrane remained.

If even one of many hollow fiber membranes is broken or damaged, the membrane-type blood processing apparatus cannot be used. Therefore, the step of loading the housing is an important step, and this step is efficient. Stabilization and stabilization greatly affect the cost of the product.

On the other hand, in the artificial dialysis device which is one of the blood treatment devices, hollow fiber membranes made of regenerated cellulose have hitherto been often used, but in recent years, polymethyl methacrylate, polysulfone, etc. have been used for the purpose of improving dialysis performance. A hollow fiber membrane type artificial dialyzer using the above synthetic polymer has been developed. These synthetic polymers have a problem that they have lower strength than regenerated cellulose hollow fiber membranes.

[0009]

[Problems to be Solved by the Invention] Artificial dialysis, plasma separation,
Hollow fiber membranes used in hollow fiber membrane blood processing apparatuses such as artificial oxygen exchangers have low breaking strength and are easily damaged. This property is particularly remarkable in synthetic polymer membranes as compared with regenerated cellulose.

Several methods as described above have been proposed in order to stably load these hollow fiber membranes at a high density without breaking them. There are such problems.

・ Running costs are high.

The hollow fiber membrane is easily damaged.

It is difficult to insert at a high filling rate.

Further, a method of inserting the hollow fiber membrane into an outer cylinder by squeezing the bundle of hollow fiber membranes in a protective wrapping material and a net in a radial direction (JP-A-61-86906 and JP-A-5-305220). ,
Actual public Sho 61-25843) is available. However, even if the hollow fiber membrane is wrapped in the protective packaging material and the net, the hollow fiber membrane bundle is squeezed in the radial direction in order to hug and tightly wind the hollow fiber membrane with the protective packaging material and the net. Disturbed by the material and the net, and the hollow fiber membranes near the outer periphery of the hollow fiber membrane bundle are preferentially aggregated and pressed, so if the volume is narrowed down more strongly than the outer periphery in order to increase the packing density, it will be close to the outer periphery. The hollow fiber membrane located is deformed, and the passage through which blood flows may be deformed and blocked.

The present invention relates to the production of a hollow fiber membrane-type blood treatment device having the above-mentioned characteristics of low breaking strength and easy damage, and it is a machine-automatable, simpler and more stable hollow fiber membrane-type blood instrument. It is an object of the invention to provide a method of manufacturing a processing device.

[0016]

In order to achieve such an object, the present invention comprises the following method and apparatus for manufacturing a hollow fiber membrane blood processing apparatus.

That is, the method for manufacturing a hollow fiber membrane-type blood treatment device in which a plurality of hollow fiber membranes are provided in a cylindrical housing is characterized by including the following steps.

(A) A bundle forming step of forming a hollow fiber membrane into a bundle (b) A packaging step of inserting the hollow fiber membrane bundle into a packaging material having vacuum resistance (c) A space in the packaging material is deaerated. A deaeration step of bringing the packaging material into close contact with the hollow fiber membrane and densely assembling the hollow fiber membrane (d) a loading step of loading the densely assembled hollow fiber membrane and the packaging material into a tubular housing (e ) Step of extracting the wrapping material between the housing and the hollow fiber membrane Further, the method is characterized by having an expanding step of expanding the wrapping material between the bundle forming step and the wrapping step in the above steps.

Furthermore, a hollow fiber membrane-type blood processing apparatus manufacturing apparatus in which a plurality of hollow fiber membranes are provided in a cylindrical housing is characterized by having the following respective elements.

(A) Hollow fiber membrane bundle gripping portion for gripping and moving the hollow fiber membrane bundle (b) Packaging material support portion for supporting at least two opposing points of the packaging material having vacuum resistance (c) Hollow fiber membrane Degassing means for degassing from the packaging material containing the bundle (d) Loading means for loading the densely gathered hollow fiber membranes and the packaging material into a cylindrical housing (e) Between the housing and the hollow fiber membranes Extraction means for extracting the packaging material Further, the above-mentioned manufacturing apparatus is characterized by having a blowing means for blowing gas into the empty packaging material.

[0021]

The operation of the present invention will be described in detail below.

The hollow fiber membrane may be made of any material and spun by any method, and it is necessary to align the required number of hollow fiber membranes in the required length and to bundle them. This gathering process is called a bundle forming process. In order to form the bundle, the both ends of the bundled hollow fiber membranes are bundled with appropriate strings, tapes or the like, but a method of gathering with a rubber band, an adhesive, a resin or the like may be used. The hollow fiber membrane bundle thus formed is gripped by the hollow fiber membrane bundle gripping unit of the manufacturing apparatus of the present invention.

The hollow fiber membrane bundle gripping portion is located at the end of the support shaft with the control motor, and the position can be changed.

On the other hand, the packaging material provided in the manufacturing apparatus is set in the packaging material supporting portion of the apparatus. This packaging material is basically one that has vacuum resistance without being damaged or vented by decompression operation. The first packaging material support portion is connected to the open end of the packaging material and the deaerator, and has an insertion port for the hollow fiber membrane bundle and an insertion port lid. The second packaging material support portion is connected to the packaging material whose end facing the first packaging material support portion is sealed, or the end of the packaging material facing the first packaging material support portion is not sealed. The first packaging material supporting portion seals an unsealed end facing the first packaging material supporting portion, and the extension of the second packaging material supporting portion passes through the inside of the tubular housing and is provided in the manufacturing apparatus casing. It is the end of the support shaft with the control motor,
You can change the position.

In the packaging step, the hollow fiber membrane bundle gripping portion is inserted into the packaging material from the opening end of the first packaging material support portion by the movement of the support shaft, and the hollow fiber membrane bundle gripping portion is inserted from the hollow fiber membrane bundle gripping portion. The membrane bundle is cut off, and the hollow fiber membrane bundle gripping unit ends by being separated from the packaging material and the first packaging material supporting unit by the movement of the support shaft.

The deaeration step is performed by closing the insertion port lid of the first packaging material support portion, starting the deaeration device, and extracting gas from the space between the packaging material and the first packaging material support portion.

By this degassing step, the packaging material is brought into close contact with the hollow fiber membranes, and by further degassing strongly, the hollow fiber membranes are brought into close contact with each other and the hollow fiber membranes are bundled at a high density. Then, the cross-sectional diameter of the hollow fiber membrane bundle is made smaller than the minimum diameter of the tubular housing.

After that, the tubular housing moves in the longitudinal direction, and the deaerated and bundled packaging material and the hollow fiber membrane are loaded into the tubular housing without mechanical damage. (Loading Step) The extracting step is performed as follows.

One end of the packaging material is opened, the packaging material moves relative to the tubular housing and the hollow fiber membrane, and the packaging material between the tubular housing and the hollow fiber membrane is pulled out. That is, the packaging material may move, or the tubular housing and the hollow fiber membrane may move at the same time. For example, the first hollow fiber membrane
Between the end on the packaging material support portion side and the first support portion, a sharp blade,
The packaging material is separated by a separating means such as a heating wire.

Next, open the opening cover of the first packaging material supporting portion,
The hollow fiber membrane bundle gripper is moved to grip only the end of the hollow fiber membrane bundle loaded in the tubular housing.

The second wrapping material support portion descends due to the movement of the support shaft, and at this time, between the tubular housing and the hollow fiber membrane,
The packaging material is removed.

By the steps and apparatus described above, the hollow fiber membrane is automatically loaded into the tubular housing without damaging the hollow fiber membrane.

In the above steps, before packaging the hollow fiber membrane bundle, a gas is blown into the packaging material connected to the first packaging material supporting portion by a blowing means for blowing sterile air, sterile nitrogen, etc. Since the packaging material can clearly form a space, the hollow fiber membrane bundle can be stably packaged.

The hollow fiber membrane bundle is put into the packaging material, and the inside of the packaging material is evacuated so that the diameter of the hollow fiber membrane bundle is minimized (the inner diameter of the hollow fiber membrane bundle is smaller than the inner diameter of the outer cylinder). It is easy to insert into the cylindrical housing, and after cutting one end of the packaging material protruding from both ends of the tubular housing in which the hollow fiber membrane is inserted, it is impossible to fix the hollow fiber membrane and pull the packaging material to remove it. It's easy.

The method of driving the components of the apparatus for manufacturing a hollow fiber membrane blood processing apparatus of the present invention is not limited to the control motor used in the description, but a generally used driving method such as an air cylinder or electromagnetic driving can be used. Needless to say.

The deaeration step is not limited to the method used in the description, but after the hollow fiber membrane bundle is packaged, the deaeration pipe communicating with the deaeration pump is inserted into the packaging material from the upper part thereof to support the first packaging material. The packing material can be degassed by sealing it with a heat sealer or a high-frequency sealer between the hollow section and the upper part of the hollow fiber membrane bundle. Good.

In the loading process, in the above description, the hollow fiber membrane was loaded into the tubular housing by ascending the tubular housing.
The same effect can be obtained by lowering the second packaging material supporting portion together with the packaging material supporting portion and the hollow fiber membrane bundle / packaging material and loading the hollow fiber membrane into the cylindrical housing.

In the conventional method for mechanically suppressing the expansion of the hollow fiber membrane bundle diameter by an external force, compression or expansion is prevented in the direction perpendicular to the fiber axis, whereas in the present invention, the inside of the packaging material is evacuated. Since the diameter of the hollow fiber membrane bundle is reduced by doing so, the hollow fiber membrane is compressed almost uniformly and is adjusted to the minimum without damaging the hollow fiber membrane, so that the hollow fiber membrane can be easily loaded, It can be loaded even with a high filling rate (65%).

Any packaging material may be used as long as it has vacuum resistance.
Nylon resin, polyamide resin, polyester resin, polyacrylic acid resin, polyolefin resin, silicone resin, vinyl chloride resin, polyvinyl resin, etc. can be used. Furthermore, when using heat sealing,
The thickness of the packaging material in which at least two materials having different melting points are laminated and the above materials can be used has a thickness of 5
-100 μm is preferred. If the thickness is less than 5 μm, the packaging material tends to be damaged, and if the thickness is more than 100 μm, it is difficult to remove the packaging material from the tubular housing.
Even more preferably, it is 10 to 30 μm.

The term "vacuum resistance" means that the internal pressure change is 1 when the packaging material is sealed after a predetermined reduced pressure state.
It shall be within 0% / hour. Hollow fiber membrane is about 250t
Since the hollow fiber membrane may be deformed when the pressure is less than orrr, there is no problem if the vacuum resistance is approximately 250 torr or less.

The hollow fiber membrane may be any hollow fiber membrane, for example, polysulfone, polyacrylonitrile, polyamide, polyimide, polymethylmethacrylate, polyether nylon, polyethylene vinyl alcohol, silicone, polyester-based polymer alloy, polyolefin-based, regenerated cellulose. , Cellulose derivatives and the like can be used.

After inserting the hollow fiber membrane into the cylindrical housing, the hollow fiber membrane is cut with a rotary blade or the like to seal the end portions of the hollow fiber membrane. Polyurethane adhesive, silicone resin, polyolefin resin, polyethylene
-Vinyl acetate resin can be used.

As described in detail above, the present invention relates to the manufacture of a hollow fiber membrane blood processing apparatus having the above-mentioned features of low breaking strength and easy damage, which can be automated by a machine and is simpler and more stable. It has become possible to provide a method for manufacturing the hollow fiber membrane blood treatment apparatus.

[0044]

【Example】

[Embodiment 1] FIG. 1 is a schematic view of an embodiment in which a hollow fiber membrane bundle and a packaging material are arranged in a manufacturing apparatus of a hollow fiber membrane-type blood processing apparatus of the present invention.

Tape both ends of the hollow fiber membrane bundle 101 (5000 polyacrylonitrile hollow fiber membranes for artificial dialysis (filling rate into the cylindrical housing calculated from the hollow fiber membrane cross-sectional area and cross-sectional shape is 65%)). Collected by 102 and 103, the hollow fiber membrane bundle gripping portion 104 of the manufacturing apparatus gripped the bundle.
The hollow fiber membrane bundle gripping portion 104 is located at the end of the support shaft 105 with the control motor 106 and can be vertically moved.

On the other hand, a polyethylene wrapping material 108 (thickness 10 μm) was set on the wrapping material supporting portions 107 and 110 of the apparatus, and sterilized air was blown into the wrapping material 108 to inflate it. The first packaging material support portion 107 is connected to the open end of the packaging material 108 and the deaerating devices 116 and 117,
It has an insertion port for the hollow fiber membrane bundle 102 and an insertion port lid 109.
The second packaging material support portion 110 is connected to the other end of the packaging material 108 that faces the opening end of the packaging material 108, and is connected to the second packaging material support portion 110.
The extension extends through the inside of the cylindrical housing 111 to the end of the support shaft 112 with the control motor 113 provided in the manufacturing apparatus housing 115, and the position can be changed.

The hollow fiber membrane bundle gripping portion 104 is moved, the hollow fiber membrane bundle 101 is inserted into the packaging material from the opening end of the first packaging material supporting portion, and the hollow fiber membrane bundle gripping portion 104 is inserted.
I cut it off. The hollow fiber membrane bundle gripping portion 104 was moved upward and separated from the packaging material 108 and the first packaging material supporting portion 107.

Next, the insertion port lid 109 of the first packaging material support 107 is closed, the deaeration device 116 is started, and the packaging material 108 is started.
And the space of the first packaging material support portion 107 is 300 torr.
The pressure was reduced to.

FIG. 2 is a schematic view from the end of the degassing process to the loading process.

The packaging material 208 was in close contact with the hollow fiber membrane bundle 201, the hollow fiber membranes were in close contact with each other, and the hollow fiber membranes were bundled at a high density. The cross-sectional diameter of the hollow fiber membrane bundle was 26.8 mm, which was smaller than the minimum diameter (28.7 mm) of the tubular housing 211.

After that, the cylindrical housing 211 is moved upward to degas and bundle the packaging material 208 and the hollow fiber membrane bundle 20.
1 was loaded into the cylindrical housing 219 without mechanical damage.

The packaging material was separated by the blade 220 of the cutter knife between the upper end 202 of the hollow fiber membrane bundle 201 and the first supporting portion 207.

Next, the opening cover 209 of the first packaging material support portion was opened, the hollow fiber membrane bundle gripping portion 204 was lowered, and only the hollow fiber membrane bundle end 202 loaded in the tubular housing 202 was gripped.

The second packaging material support portion 210 was lowered by the movement of the support shaft 212. Then, the tubular housing 219
The packaging material 208 separated from the space between the hollow fiber membrane bundle 201 and the hollow fiber membrane bundle 201.
I pulled it out.

The cylindrical housing 219 of the hollow fiber membrane bundle 201
After cutting the both ends protruding further, the cut surface of the hollow fiber membrane bundle was sealed with a molten polyethylene-vinyl acetate resin. A hollow fiber membrane-type blood treatment device of the present invention was produced by centrifugally injecting a urethane adhesive and slicing it.

[Example 2] A hollow fiber membrane bundle of 5000 polysulfone hollow fiber membranes for artificial dialysis (filling rate 65%) was loaded into a cylindrical housing in the same manner as in Example 1 to obtain the hollow fiber of the present invention. A thread film type blood processing apparatus was produced.

[Comparative Example 1] A hollow fiber membrane bundle of 5000 polysulfone hollow fiber membranes similar to that of Example 2 was prepared, and then wrapped with a protective paper (Sunlilies, Toyo Kokusaku Pulp Co., Ltd.) into a tubular housing. For loading, the cross-sectional outer diameter of the hollow fiber membrane bundle is 2
It was tightened to 7.0 mm and loaded in the same cylindrical housing as in Example 2. The hollow fiber membrane bundle coming out of the outer cylinder was fixed with a urethane adhesive, and the urethane adhesive was centrifugally injected and then sliced to prepare a hollow fiber membrane blood treatment apparatus.

[Test Example 1] The roundness of the hollow fiber membrane bundle diameter on the sliced surface of Example 2 and that of Comparative Example 1 were compared in Table 1 to examine the disorder of the hollow fiber membrane.

[0059]

[Table 1]

From Table 1, it was confirmed that Example 2 of the method of the present invention had a higher roundness than Comparative Example 1 of the conventional method, and that the disorder of the hollow fiber membrane during the production was small.

[Test Example 2] With the particle counter of Example 2 and Comparative Example 1 (Lion Co., Ltd., light scattering type particle counter KC-01), the dust in the air passing through the membrane was measured. By doing so, a leak inspection was performed. Table 2 shows the results.

[0062]

[Table 2]

The leak rate of the module prototyped by the method of the present invention was lower than the leak rate of the module prototyped by the conventional method.

[Embodiment 3] FIG. 3 is a schematic view of an embodiment in which a hollow fiber membrane bundle and a packaging material are arranged in another manufacturing apparatus of the hollow fiber membrane blood processing apparatus of the present invention.

Tape both ends of the hollow fiber membrane bundle 301 (5000 polyacrylonitrile hollow fiber membranes for artificial dialysis (filling rate into the tubular housing calculated from the hollow fiber membrane cross-sectional area and cross-sectional shape is 65%)). Collected by 312 and 313, they were held by the hollow fiber membrane bundle holding section 314 of the manufacturing apparatus.
The hollow fiber membrane bundle gripping portion 314 is located at the end of the pulling jig 306 and can be vertically moved.

On the other hand, a polyethylene-polyester laminate packaging material 302 (thickness: 50 μm) is set on the packaging material supporting portions 311 and 315 of the apparatus, and sterilized air is used as the packaging material 30.
Blow into 2 and inflate. First packaging material support 31
1 is the open end of the packaging material 302 and the deaeration devices 305, 3
It is connected with 10. The second packaging material support portion 315 is connected to the other end of the packaging material 302 that faces the opening end of the packaging material 302.
The extension of the second packaging material support portion 315 is formed by the tubular housing 30.
It passes through the inside of the cylinder No. 3 and is the end of the lower traction device 309, and the position can be changed.

The hollow fiber membrane bundle gripping portion 314 is moved, the hollow fiber membrane bundle 301 is inserted into the packaging material through the opening end of the first packaging material supporting portion, and the hollow fiber membrane bundle gripping portion 314 is inserted into the hollow fiber membrane bundle 301.
I cut it off. The hollow fiber membrane gripping portion 314 is moved upward, and the vacuum resistant packaging material 302 and the first packaging material support portion 31 are moved.
I was separated from 1.

Next, the deaeration pipe 310 communicating with the deaeration pump 305 is inserted into the packaging material 302 from above, the heat sealing machine 304 is pushed out from the left and right, and the first packaging material support portion 311 is provided.
And the upper end of the hollow fiber membrane bundle 301 put in the packaging material were heat-sealed. At this time, the tip of the deaeration pipe 310 was positioned below the heat seal part. The degassing pump was operated to reduce the pressure to 300 torr. After depressurization, the deaeration pipe was pulled out, and the packaging material was sealed again by the heat sealing machine.

The packaging material 302 was in close contact with the hollow fiber membrane bundle 301, and the hollow fiber membranes were in close contact with each other, so that the hollow fiber membrane bundle was converged at a high density. The cross-sectional diameter of the hollow fiber membrane bundle was 26.9 mm, which was smaller than the minimum diameter (28.7 mm) of the tubular housing 303.

After that, at the same time when the second wrapping material support portion is pulled down, the housing upper part 307 to which the first wrapping material support portion is fixed is moved downward to make a hollow fiber membrane bundle-wrapping material contact body. Was loaded into the cylindrical housing 303.

The upper end 312 of the hollow fiber membrane bundle 301 and the packaging material 3
The heat-sealed part of 02 was cut with scissors.

Next, the hollow fiber membrane bundle gripping portion 314 is lowered to grip the hollow fiber membrane bundle upper portion 312 loaded in the tubular housing 303, and the second packaging material support portion 315 is moved downward to form a cylinder. The separated packaging material 302 was extracted from between the hollow housing 303 and the hollow fiber membrane bundle 301.

Cylindrical housing 303 of hollow fiber membrane bundle 301
After cutting the both ends protruding further, the cut surface of the hollow fiber membrane bundle was sealed with a molten polyethylene-vinyl acetate resin. A hollow fiber membrane-type blood treatment device of the present invention was produced by centrifugally injecting a urethane adhesive and slicing it.

[0074]

The hollow fiber membrane is put into a vacuum-resistant thin packaging material by the method for manufacturing a hollow fiber membrane-type blood treatment device according to the present invention.
By vacuuming the inside of the packaging material to minimize the hollow fiber membrane bundle diameter, insertion into the tubular housing is simplified, and the hollow fiber membrane bundle is fixed from the tubular housing in which the hollow fiber membrane is inserted. After that, by pulling away the packaging material, the hollow fiber membrane is loaded into the tubular housing without being disturbed or damaged in the tubular housing, and the hollow fiber membrane blood treatment apparatus can be more easily obtained. There is an effect.

By blowing a gas into the packaging material with a blowing means for blowing sterile air, sterile nitrogen, etc.,
Since the packaging material can form a clear space, the hollow fiber membrane bundle can be stably packaged.

Furthermore, in a manufacturing apparatus of a hollow fiber membrane type blood processing apparatus in which a plurality of hollow fiber membranes are provided in a cylindrical housing, a hollow fiber membrane bundle gripping portion for gripping and moving the hollow fiber membrane bundle and vacuum resistance. A packaging material supporting portion that supports the packaging material having at least two points facing each other, a degassing unit that degasses the inside of the packaging material that contains the bundle of hollow fiber membranes, and the hollow fiber membrane and the packaging material that are densely assembled. By having a loading means for loading into a hollow housing and a withdrawing means for withdrawing the packaging material between the housing and the hollow fiber membrane, without disturbing or damaging the hollow fiber membrane,
It can be loaded into the tubular housing, and the hollow fiber membrane blood treatment apparatus can be efficiently and simply manufactured.

Further, in the above-mentioned manufacturing apparatus, since the empty space is provided with a blowing means for blowing gas, a clear space can be formed in the space, so that the hollow fiber membrane bundle is stably packaged. It becomes a device.

[0078]

[Brief description of drawings]

FIG. 1 is a schematic view in which a hollow fiber membrane bundle and a packaging material of a manufacturing apparatus of the present invention are arranged.

2 is a schematic view of the manufacturing apparatus shown in FIG. 1 of the present invention from the end of the degassing step to the loading step.

FIG. 3 is a schematic diagram of another embodiment of the present invention.

[Explanation of symbols]

101, 201, 301: Hollow fiber membrane bundle 102, 103, 202, 203, 312, 313: Bundle forming tape 104, 204, 314: Hollow fiber membrane bundle gripping portion 105, 112, 205, 212: Support shaft 106, 113, 206, 213: Support shaft control motors 306, 309: Traction device 107, 207, 311: First packaging material support portion 108, 208, 302: Packaging material 109, 209: First packaging material support portion opening lid 110 , 210, 315: second packaging material support portions 111, 211, 219, 303: tubular housings 114, 214, 218, 308: tubular housing support portions 115, 215, 307: housings 116, 216, 305: removal Air pump 117, 217, 310: Deaeration pipe 119, 220: Separation tool 304: Heat sealing machine

Claims (4)

[Claims] 1. A method for manufacturing a hollow fiber membrane-based blood treatment apparatus in which a plurality of hollow fiber membranes are provided in a cylindrical housing, comprising the following steps: Production method. (a) A bundle forming step of forming a hollow fiber membrane into a bundle (b) A packaging step of inserting the hollow fiber membrane bundle into a packaging material having vacuum resistance (c) A space in the packaging material is deaerated and the packaging is performed. Deaeration step of closely adhering the material to the hollow fiber membrane and densely assembling the hollow fiber membranes (d) loading step of loading the densely gathered hollow fiber membranes and the packaging material into a cylindrical housing (e) a housing A step of extracting the packaging material between the hollow fiber membranes. 2. The method for manufacturing a hollow fiber membrane type body fluid treatment device according to claim 1, further comprising an expansion step for expanding the packaging material between the bundle forming step and the packaging step. 3. A hollow fiber membrane-based blood processing apparatus, comprising: a hollow fiber membrane-based blood processing apparatus having a plurality of hollow fiber membranes provided in a tubular housing; Manufacturing equipment. (a) Hollow fiber membrane bundle gripping portion that grips and moves the hollow fiber membrane bundle (b) Packaging material supporting portion that supports at least two opposing points of the packaging material having vacuum resistance (c) Contains hollow fiber membrane bundle Degassing means for degassing from inside the packaging material (d) densely assembled hollow fiber membranes and loading means for loading the packaging material into a cylindrical housing (e) the packaging material between the housing and the hollow fiber membranes A means for extracting. 4. An apparatus for manufacturing a hollow fiber membrane blood processing apparatus according to claim 3, further comprising a blowing means for blowing gas into the empty packaging material.