JPH05192397A - Manufacture of hemocatharsis device - Google Patents
Manufacture of hemocatharsis deviceInfo
- Publication number
- JPH05192397A JPH05192397A JP4007210A JP721092A JPH05192397A JP H05192397 A JPH05192397 A JP H05192397A JP 4007210 A JP4007210 A JP 4007210A JP 721092 A JP721092 A JP 721092A JP H05192397 A JPH05192397 A JP H05192397A
- Authority
- JP
- Japan
- Prior art keywords
- blood purification
- glycerin
- membrane
- purification apparatus
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は血液浄化装置の製造方法
に関し、さらに詳しくは、γ線滅菌を行なう血液浄化装
置の製造方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for manufacturing a blood purification device, and more particularly to a method for manufacturing a blood purification device for γ-ray sterilization.
【０００２】[0002]
【従来技術と発明が解決しようとする課題】一般に、血
液浄化装置の製造方法において、γ線滅菌が行なわれて
いる。2. Description of the Related Art Generally, .gamma.-ray sterilization is performed in a method for manufacturing a blood purification device.
【０００３】たとえば、従来、血液浄化装置内を実質的
に乾燥状態にし、この乾燥状態を維持したままγ線処理
をする、いわゆる乾式の血液浄化装置の滅菌方法が行な
われていた。この方法においては、膜の材質がセルロー
スアセテート類であるときには、γ線滅菌により血液浄
化装置内の膜が劣化してしまうので、予め膜にグリセリ
ンを付着させてからγ線を照射する等の改良がなされて
いた。しかしながら、この改良により膜の劣化を防止す
ることはできても、使用前に血液浄化装置内を生理食塩
水でプライミングをする際に、膜内に気泡が残らないよ
うに丁寧な脱泡操作をしなければならないという欠点が
あった。For example, conventionally, a so-called dry-type blood purification apparatus sterilization method has been performed in which the inside of the blood purification apparatus is substantially dried and γ-ray treatment is performed while maintaining this dry state. In this method, when the material of the membrane is cellulose acetates, the membrane in the blood purification apparatus deteriorates due to γ-ray sterilization, so improvement such as γ-ray irradiation after attaching glycerin to the membrane in advance Was being done. However, although this improvement can prevent the membrane from deteriorating, when priming the blood purification device with physiological saline before use, a careful defoaming operation should be performed to prevent bubbles from remaining in the membrane. It had the drawback of having to do it.
【０００４】そこで最近では、上記の脱泡操作を簡便に
するために、予め血液浄化装置内に水または溶液を充填
し、生理食塩水の置換を容易に行なえるようにした血液
浄化装置、いわゆるウエットタイプの血液浄化装置の製
造が増加している。このウエットタイプの血液浄化装置
の製造方法においては、一般に、血液浄化装置内に水お
よび溶液を充填した後にγ線を照射するという滅菌方法
を行なう。しかしながら、この滅菌方法においては、上
記のような脱泡操作を必要とはしないが、やはり膜の材
質上、γ線滅菌により膜が劣化するという欠点があっ
た。Therefore, recently, in order to simplify the above-mentioned defoaming operation, a blood purifying apparatus in which water or a solution is previously filled in the blood purifying apparatus so that the physiological saline can be easily replaced, a so-called blood purifying apparatus is known. The production of wet type blood purification devices is increasing. In the method of manufacturing the wet type blood purifying apparatus, generally, a sterilization method is performed in which the blood purifying apparatus is filled with water and a solution and then irradiated with γ-rays. However, this sterilization method does not require the defoaming operation as described above, but also has a drawback that the film deteriorates due to γ-ray sterilization due to the material of the film.
【０００５】そこで、このウエットタイプの血液浄化装
置の滅菌方法において、予め膜にグリセリンを付着させ
てから水を充填するという方法が見出された。しかしな
がら、水を充填する際にグリセリンが洗い出されるため
に、結局、グリセリンによる劣化防止の効果を生かすこ
とができなかった。本発明は前記事情に基づいてなされ
たものである。本発明の目的は、γ線照射により劣化し
やすい材質からなる膜を有していても、劣化を起こすこ
となくγ線で滅菌され、しかも使用前の脱泡操作が不要
な血液浄化装置の製造方法を提供することにある。Therefore, in the sterilization method of this wet-type blood purification apparatus, a method has been found in which glycerin is previously attached to the membrane and then water is filled. However, since glycerin is washed out when water is filled, the effect of preventing deterioration due to glycerin cannot be utilized in the end. The present invention has been made based on the above circumstances. An object of the present invention is to manufacture a blood purification apparatus that has a membrane made of a material that is easily deteriorated by γ-ray irradiation, is sterilized by γ-ray without causing deterioration, and requires no defoaming operation before use. To provide a method.
【０００６】[0006]
【前記課題を解決するための手段】前記課題を解決する
ための本発明は、γ線滅菌により劣化しやすい材質の膜
を有する血液浄化装置本体内に０．１〜５ｗ／ｖ％［重
量／容量％］のグリセリン水溶液を充填した後、γ線滅
菌することを特徴とする血液浄化装置の製造方法であ
る。According to the present invention for solving the above-mentioned problems, 0.1 to 5 w / v% [weight / weight] is provided in a main body of a blood purification apparatus having a membrane made of a material which is easily deteriorated by γ-ray sterilization. [% By volume] glycerin aqueous solution, and then γ-ray sterilization is performed.
【０００７】以下に、本発明を詳細に説明する。本願発
明の方法で製造される血液浄化装置は、γ線滅菌により
劣化しやすい材質の膜と前記膜を装填するケース本体と
を有する。なお、本願でいう血液浄化装置は、これらの
部材を有する装置であれば特に限定はなく、血液透析用
に限らず、血奨分離用にも利用することのできる透析装
置および限外濾過装置等を包含する。The present invention will be described in detail below. The blood purification apparatus manufactured by the method of the present invention has a membrane made of a material that is easily deteriorated by γ-ray sterilization and a case body into which the membrane is loaded. The blood purification apparatus referred to in the present application is not particularly limited as long as it is an apparatus having these members, and is not limited to hemodialysis but can be used for blood separation as well as dialysis equipment and ultrafiltration equipment. Includes.
【０００８】例えば、本発明における血液浄化装置の一
例を図１に示す。図１に示すように、血液浄化装置は、
内部に膜８を装備した円筒形のケース１０と、このケー
ス本体１０の両端に弾性シール部材１４を介して装備さ
れるとともに、血液導出入口１６を備えた血液導入部材
１２と、このケース本体１０の端部近傍の周側面に外側
に向かって突設形成された透析液導出入口２０および前
記血液導出入口１６それぞれに装備された充填水用封止
体１８とを有する。For example, FIG. 1 shows an example of the blood purification apparatus according to the present invention. As shown in FIG. 1, the blood purification device is
A cylindrical case 10 equipped with a membrane 8 inside, a blood introducing member 12 equipped with a blood inlet / outlet port 16 while being equipped with elastic seal members 14 at both ends of the case main body 10, and the case main body 10 A dialysate outlet 20 and a filling water sealer 18 mounted on the blood inlet 16 are formed on the peripheral side surface near the end of the outlet protruding outward.
【０００９】γ線滅菌により劣化しやすい材質として
は、滅菌に必要な量のγ線が照射されたときに、イオ
ン、励起分子、ラジカルなどを生成し、主鎖の切断、鎖
間の架橋および側鎖グループの分解を起こす高分子化合
物等が挙げられる。具体的には、セルロースアセテート
類が挙げられ、特にセルロースアセテート、セルロース
ジアセテート、セルローストリアセテート等が適する。
上記のような材質からなる膜としては、中空糸、平膜等
の半透膜等が挙げられるが、透析膜あるいは限外濾過膜
等に利用できる膜であれば特に限定はない。Materials that are easily deteriorated by γ-ray sterilization generate ions, excited molecules, radicals, etc., when the amount of γ-rays required for sterilization is irradiated to break the main chain, crosslink between chains and Examples thereof include polymer compounds that cause decomposition of side chain groups. Specific examples thereof include cellulose acetates, and particularly, cellulose acetate, cellulose diacetate, cellulose triacetate and the like are suitable.
Examples of the membrane made of the above materials include a hollow fiber, a semipermeable membrane such as a flat membrane, and the like, but the membrane is not particularly limited as long as it can be used as a dialysis membrane or an ultrafiltration membrane.
【００１０】本願発明の方法においては、前記血液浄化
装置内にグリセリン水溶液を充填する。本発明における
グリセリン水溶液とは、グリセリンを水に溶解した溶液
である。上記グリセリンの濃度としては、通常０．１〜
５ｗ／ｖ％が好ましい。上記グリセリンの濃度が５ｗ／
ｖ％を越えると、滅菌後にグリセリンを除去するための
洗浄操作が煩雑になる。また、上記グリセリンの濃度が
０．１ｗ／ｖ％未満であると、グリセリンによる劣化防
止効果が十分に発揮されないので、前記膜がγ線照射に
より劣化する。また、上記グリセリン水溶液は、充填さ
れる前に予め脱気されているのが好ましい。脱気の方法
としては、特に制限はないが、例えば容器内に収容した
グリセリン水溶液を氷結し、次いでその容器内を真空に
引きつつ解凍することによる方法（減圧解凍法）等を挙
げることができる。In the method of the present invention, the blood purification apparatus is filled with an aqueous glycerin solution. The glycerin aqueous solution in the present invention is a solution in which glycerin is dissolved in water. The concentration of glycerin is usually 0.1 to
5 w / v% is preferable. The glycerin concentration is 5 w /
If it exceeds v%, the washing operation for removing glycerin after sterilization becomes complicated. Further, if the concentration of glycerin is less than 0.1 w / v%, the effect of preventing deterioration due to glycerin will not be sufficiently exerted, so the film will be deteriorated by γ-ray irradiation. Further, it is preferable that the glycerin aqueous solution is degassed in advance before being filled. The degassing method is not particularly limited, and examples thereof include a method in which a glycerin aqueous solution contained in a container is frozen, and then the container is thawed while being evacuated (vacuum thawing method). ..
【００１１】本発明における充填とは、血液浄化装置内
に気泡が存在しないように前記グリセリン水溶液を液密
に封入することを意味する。具体的には、膜の内外側お
よびケース本体内にグリセリン水溶液が液密に封入され
ている状態を意味する。膜は微細構造を有するので、こ
の空孔部分においてもグリセリン水溶液が充満されるよ
うに充填するのが好ましい。また、膜の外側およびケー
スの内部とは、ケース内部において装填された膜以外の
部分を表わし、この部分にも完全にグリセリン水溶液が
充満されるように充填する。したがって、実質上、ケー
ス内部において装填された膜は、上記グリセリ水溶液を
含浸している。Filling in the present invention means liquid-tightly sealing the aqueous glycerin solution so that air bubbles do not exist in the blood purification apparatus. Specifically, it means a state in which the glycerin aqueous solution is liquid-tightly sealed inside and outside the membrane and inside the case body. Since the membrane has a fine structure, it is preferable to fill the pores with the aqueous glycerin solution. Further, the outside of the membrane and the inside of the case refer to a portion other than the membrane loaded inside the case, and this portion is also filled so as to be completely filled with the glycerin aqueous solution. Therefore, substantially, the film loaded inside the case is impregnated with the aqueous glycerin solution.
【００１２】上記充填の方法としては、前記グリセリン
水溶液を液密に封入することができる限りは特に制限が
なく、グリセリン水溶液を血液浄化装置内に収容してか
ら、血液浄化装置内を脱気する方法等が挙げられる。た
とえば、図１のような血液浄化装置においては、膜８が
中空糸である場合には、中空糸の内側である中空部分に
も、中空糸の外側部分でかつケース本体１０の内側部分
にも、上記グリセリン水溶液が液密に封入されるように
充填する。そして、血液浄化装置内に前記グリセリン水
溶液が充填されると、通常、透析液導出入口２０および
前記血液導出入口１６それぞれが充填水用封止体１８で
密封される。The filling method is not particularly limited as long as the glycerin aqueous solution can be sealed in a liquid-tight manner, and the glycerin aqueous solution is housed in the blood purification apparatus and then the blood purification apparatus is degassed. Methods and the like. For example, in the blood purification apparatus as shown in FIG. 1, when the membrane 8 is a hollow fiber, it can be used both in the hollow part inside the hollow fiber and in the outer part of the hollow fiber and the inner part of the case body 10. The glycerin aqueous solution is filled so as to be liquid-tightly sealed. When the blood purification apparatus is filled with the glycerin aqueous solution, the dialysate outlet 20 and the blood outlet 16 are usually sealed with the filling water sealing body 18.
【００１３】本発明の方法においては、前記グリセリン
水溶液を充填した後、血液浄化装置にγ線を照射する。
本発明において使用されるγ線としては、60Ｃｏ、 137
Ｃｓなどのγ線が好ましい。総照射線量としては、通常
５０ｋＧｙ以下が好ましく、さらに好ましくは１５〜３
０ｋＧｙの範囲が好ましい。照射方法としては、通常用
いられるいかなる方法をも用いることができる。In the method of the present invention, after filling the glycerin aqueous solution, the blood purifying apparatus is irradiated with γ-rays.
The gamma rays used in the present invention include 60 Co, 137
Gamma rays such as Cs are preferred. The total irradiation dose is usually preferably 50 kGy or less, more preferably 15 to 3
A range of 0 kGy is preferred. As the irradiation method, any commonly used method can be used.
【００１４】本発明においては、前記グリセリン水溶液
を充填した状態で前記血液浄化装置を包装し、包装した
状態でγ線を照射してもよい。上記包装の方法について
は、特に限定はなく、例えば真空包装等を行なうことが
できる。上記真空包装を行なう場合においては、例え
ば、グリセリン水溶液が充填された前記血液浄化装置を
滅菌バックに入れ、その後に滅菌バック内を真空ポンプ
で真空にして端部シールする方法が挙げられる。In the present invention, the blood purification device may be packaged in a state of being filled with the glycerin aqueous solution, and the packaged state may be irradiated with γ-rays. The packaging method is not particularly limited, and for example, vacuum packaging can be performed. In the case of performing the above-mentioned vacuum packaging, for example, there is a method in which the blood purification device filled with the aqueous glycerin solution is placed in a sterilization bag, and then the inside of the sterilization bag is evacuated by a vacuum pump to seal the ends.
【００１５】上述のようにして、包装された状態でγ線
を照射された前記血液浄化装置は、包装されたままの状
態で保存、輸送することができる。したがって、グリセ
リン水溶液が充填されている血液浄化装置を包装された
状態で工場から出荷することができる。また、使用に際
しては、上述した洗浄方法と同様の方法により、前記血
液浄化装置に充填されているグリセリン水溶液を洗浄す
る。As described above, the blood purification apparatus irradiated with γ-rays in the packaged state can be stored and transported in the packaged state. Therefore, the blood purification device filled with the aqueous glycerin solution can be shipped from the factory in a packaged state. In use, the aqueous glycerin solution filled in the blood purification device is washed by the same method as the above-mentioned washing method.
【００１６】[0016]
（実施例１）図１に示すような血液浄化装置内に、０．
１ｗ／ｖ％のグリセリン水溶液を液密に充填した後、血
液浄化装置を包装し、包装した状態でγ線を２５ｋＧｙ
または５０ｋＧｙ照射した。その後、血液浄化装置内を
滅菌水および生理食塩水で十分に洗浄し、充填していた
グリセリン水溶液を除去した。得られた血液浄化装置に
ついて、下記の条件下で、４時間の膜の耐圧試験を実施
した。(Embodiment 1) In a blood purification apparatus as shown in FIG.
After liquid-tightly filling a 1 w / v% glycerin aqueous solution, the blood purification device was packaged, and γ rays were 25 kGy in the packaged state.
Or it was irradiated with 50 kGy. Then, the inside of the blood purification apparatus was thoroughly washed with sterilized water and physiological saline to remove the filled glycerin aqueous solution. The obtained blood purification apparatus was subjected to a membrane pressure resistance test for 4 hours under the following conditions.
【００１７】 血液側入口流量 ２００ｍｌ／分 透析液側入口流量 ５００ｍｌ／分 膜間圧力差（ＴＭＰ） １ｋｇ／ｃｍ2 温度 ３７℃ その結果を表１に示す。表１が示すように、０．１ｗ／
ｖ％のグリセリン水溶液を血液浄化装置内に充填した状
態で２５ｋＧｙまたは５０ｋＧｙのγ線照射を行なって
も、膜材質の劣化は認められなかった。Blood-side inlet flow rate 200 ml / min Dialysate-side inlet flow rate 500 ml / min Transmembrane pressure difference (TMP) 1 kg / cm 2 Temperature 37 ° C. The results are shown in Table 1. As shown in Table 1, 0.1 w /
No deterioration of the film material was observed even when γ-ray irradiation of 25 kGy or 50 kGy was performed with the v% glycerin aqueous solution filled in the blood purification apparatus.
【００１８】（実施例２）グリセリン水溶液の濃度を
０．３ｗ／ｖ％にしたほかは実施例１と同様にして、得
られた血液浄化装置について膜の耐圧試験を実施した。
その結果を表１に示す。表１が示すように、０．３ｗ／
ｖ％のグリセリン水溶液を血液浄化装置内に充填した状
態で２５ｋＧｙまたは５０ｋＧｙのγ線照射を行なって
も、膜材質の劣化は認められなかった。Example 2 A membrane pressure resistance test was performed on the obtained blood purification apparatus in the same manner as in Example 1 except that the concentration of the glycerin aqueous solution was 0.3 w / v%.
The results are shown in Table 1. As shown in Table 1, 0.3 w /
No deterioration of the film material was observed even when γ-ray irradiation of 25 kGy or 50 kGy was performed with the v% glycerin aqueous solution filled in the blood purification apparatus.
【００１９】（実施例３）グリセリン水溶液の濃度を
１．０ｗ／ｖ％にしたほかは実施例１と同様にして、得
られた血液浄化装置について膜の耐圧試験を実施した。
その結果を表１に示す。表１が示すように、１．０ｗ／
ｖ％のグリセリン水溶液を血液浄化装置内に充填した状
態で２５ｋＧｙまたは５０ｋＧｙのγ線照射を行なって
も、膜材質の劣化は認められなかった。Example 3 A membrane pressure resistance test was conducted on the obtained blood purification apparatus in the same manner as in Example 1 except that the concentration of the glycerin aqueous solution was 1.0 w / v%.
The results are shown in Table 1. As shown in Table 1, 1.0 w /
No deterioration of the film material was observed even when γ-ray irradiation of 25 kGy or 50 kGy was performed with the v% glycerin aqueous solution filled in the blood purification apparatus.
【００２０】（実施例４）グリセリン水溶液の濃度を
３．０ｗ／ｖ％にしたほかは実施例１と同様にして、得
られた血液浄化装置について膜の耐圧試験を実施した。
その結果を表１に示す。表１が示すように、３．０ｗ／
ｖ％のグリセリン水溶液を血液浄化装置内に充填した状
態で２５ｋＧｙまたは５０ｋＧｙのγ線照射を行なって
も、膜材質の劣化は認められなかった。Example 4 A membrane pressure resistance test was conducted on the obtained blood purification apparatus in the same manner as in Example 1 except that the concentration of the glycerin aqueous solution was 3.0 w / v%.
The results are shown in Table 1. As shown in Table 1, 3.0 w /
No deterioration of the film material was observed even when γ-ray irradiation of 25 kGy or 50 kGy was performed with the v% glycerin aqueous solution filled in the blood purification apparatus.
【００２１】（実施例５）グリセリン水溶液の濃度を
５．０ｗ／ｖ％にしたほかは実施例１と同様にして、得
られた血液浄化装置について膜の耐圧試験を実施した。
その結果を表１に示す。表１が示すように、５．０ｗ／
ｖ％のグリセリン水溶液を血液浄化装置内に充填した状
態で２５ｋＧｙまたは５０ｋＧｙのγ線照射を行なって
も、膜材質の劣化は認められなかった。Example 5 A membrane pressure resistance test was performed on the obtained blood purification apparatus in the same manner as in Example 1 except that the concentration of the glycerin aqueous solution was 5.0 w / v%.
The results are shown in Table 1. As shown in Table 1, 5.0 w /
No deterioration of the film material was observed even when γ-ray irradiation of 25 kGy or 50 kGy was performed with the v% glycerin aqueous solution filled in the blood purification apparatus.
【００２２】（比較例１）グリセリン水溶液の代わりに
グリセリンを含まない水を使用したほかは実施例１と同
様にして、得られた血液浄化装置について膜の耐圧試験
を実施した。その結果を表１に示す。表１が示すよう
に、２５ｋＧｙまたは５０ｋＧｙのγ線照射により膜材
質の劣化が認められた。Comparative Example 1 A membrane pressure resistance test was conducted on the obtained blood purification apparatus in the same manner as in Example 1 except that glycerin-free water was used in place of the glycerin aqueous solution. The results are shown in Table 1. As shown in Table 1, deterioration of the film material was observed by γ-ray irradiation of 25 kGy or 50 kGy.
【００２３】[0023]
【表１】 [Table 1]
【００２４】[0024]
【発明の効果】本発明によると、γ線滅菌によって劣化
しやすい材質の膜が使用されていても劣化しないように
γ線照射をすることができるので、脱泡操作が簡便なウ
エットタイプであり、しかもγ線滅菌による膜の劣化の
少ない血液浄化装置を提供することができる。EFFECTS OF THE INVENTION According to the present invention, γ-ray irradiation can be performed so as not to deteriorate even if a film made of a material which is easily deteriorated by γ-ray sterilization is used. Moreover, it is possible to provide a blood purification device in which the deterioration of the membrane due to γ-ray sterilization is small.
【図１】本発明の方法に使用する一例としての血液浄化
装置を示す概略説明図である。FIG. 1 is a schematic explanatory view showing an example of a blood purification device used in the method of the present invention.
８ 膜 １０ ケース本体 １２ 血液導出入部材 １４ 弾性シール材 １６ 血液導出入口 １８ 充填水用封止体 ２０ 透析液導出入口 8 Membrane 10 Case Main Body 12 Blood Outlet / Inlet Member 14 Elastic Sealing Material 16 Blood Outlet Inlet 18 Sealing Body for Filling Water 20 Dialysate Outlet Inlet
Claims (1)
有する血液浄化装置本体内に０．１〜５ｗ／ｖ％のグリ
セリン水溶液を充填した後、γ線滅菌することを特徴と
する血液浄化装置の製造方法。1. A blood purification method characterized by γ-ray sterilization after filling 0.1 to 5 w / v% glycerin aqueous solution into a blood purification apparatus main body having a membrane made of a material which is easily deteriorated by γ-ray sterilization. Device manufacturing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4007210A JP2672051B2 (en) | 1992-01-20 | 1992-01-20 | Method for manufacturing blood purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4007210A JP2672051B2 (en) | 1992-01-20 | 1992-01-20 | Method for manufacturing blood purification device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05192397A true JPH05192397A (en) | 1993-08-03 |
| JP2672051B2 JP2672051B2 (en) | 1997-11-05 |
Family
ID=11659645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4007210A Expired - Fee Related JP2672051B2 (en) | 1992-01-20 | 1992-01-20 | Method for manufacturing blood purification device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2672051B2 (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0672424A1 (en) * | 1994-03-16 | 1995-09-20 | Teijin Limited | Method of sterilizing a blood dialyzer having semipermeable polymeric membranes by gamma-ray irradiation |
| WO2002045830A1 (en) * | 2000-12-08 | 2002-06-13 | Hospal Industrie | Apparatus for extracorporeal blood or plasma treatment comprising a wet semipermeable membrane and methods for making same |
| JP2005334318A (en) * | 2004-05-27 | 2005-12-08 | Toyobo Co Ltd | High strength and high water permeability hollow fiber membrane type hemocatharsis apparatus |
| JPWO2004018085A1 (en) * | 2002-08-21 | 2005-12-08 | 東レ株式会社 | Modified substrate and method for producing modified substrate |
| US6986868B2 (en) | 1998-11-20 | 2006-01-17 | Coloplast A/S | Method for sterilizing a medical device having a hydrophilic coating |
| JP2006271430A (en) * | 2005-03-28 | 2006-10-12 | Toyobo Co Ltd | Method of sterilizing blood purifying module |
| JP2006289071A (en) * | 2005-03-18 | 2006-10-26 | Toray Ind Inc | Sterilization method for compound |
| EP1131112B2 (en) † | 1998-11-20 | 2006-11-29 | Coloplast A/S | A method for sterilising a medical device having a hydrophilic coating |
| JP2007296145A (en) * | 2006-04-28 | 2007-11-15 | Toyobo Co Ltd | Blood purifier |
| JP2007301007A (en) * | 2006-05-09 | 2007-11-22 | Toyobo Co Ltd | Blood purifier |
| EP1894965A4 (en) * | 2005-03-29 | 2008-06-18 | Toray Industries | Modified substrate and process for production thereof |
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|---|---|---|---|---|
| JPS5299697A (en) * | 1976-02-17 | 1977-08-20 | Toray Industries | Method of sterilizing living body dialyzer |
| JPS59232555A (en) * | 1983-05-28 | 1984-12-27 | アクゾ・エヌ・ヴエ− | Cleaning treatment of assembled dialyzer |
| JPS60165959A (en) * | 1984-02-08 | 1985-08-29 | 東レ株式会社 | Sterilization of artificial organ |
| JPS6246190A (en) * | 1985-08-26 | 1987-02-28 | 石川島播磨重工業株式会社 | Hot isotropic pressure press device |
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1992
- 1992-01-20 JP JP4007210A patent/JP2672051B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5299697A (en) * | 1976-02-17 | 1977-08-20 | Toray Industries | Method of sterilizing living body dialyzer |
| JPS59232555A (en) * | 1983-05-28 | 1984-12-27 | アクゾ・エヌ・ヴエ− | Cleaning treatment of assembled dialyzer |
| JPS60165959A (en) * | 1984-02-08 | 1985-08-29 | 東レ株式会社 | Sterilization of artificial organ |
| JPS6246190A (en) * | 1985-08-26 | 1987-02-28 | 石川島播磨重工業株式会社 | Hot isotropic pressure press device |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658466A (en) * | 1994-03-16 | 1997-08-19 | Teijin Limited | Method of sterilizing a blood dialyzer having semipermeable polymeric membranes by γ-ray irradiation |
| EP0672424A1 (en) * | 1994-03-16 | 1995-09-20 | Teijin Limited | Method of sterilizing a blood dialyzer having semipermeable polymeric membranes by gamma-ray irradiation |
| US6986868B2 (en) | 1998-11-20 | 2006-01-17 | Coloplast A/S | Method for sterilizing a medical device having a hydrophilic coating |
| EP1131112B2 (en) † | 1998-11-20 | 2006-11-29 | Coloplast A/S | A method for sterilising a medical device having a hydrophilic coating |
| US9138510B2 (en) | 1998-11-20 | 2015-09-22 | Coloplast A/S | Sterilized ready-to-use catheter |
| WO2002045830A1 (en) * | 2000-12-08 | 2002-06-13 | Hospal Industrie | Apparatus for extracorporeal blood or plasma treatment comprising a wet semipermeable membrane and methods for making same |
| FR2817769A1 (en) * | 2000-12-08 | 2002-06-14 | Hospal Ind | APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD OR PLASMA COMPRISING A HUMID SEMI-PERMEABLE MEMBRANE AND METHODS OF MAKING |
| US7077961B2 (en) | 2000-12-08 | 2006-07-18 | Hospal Industrie | Apparatus for extracorporeal blood or plasma treatment comprising a wet semi-permeable membrane and methods for making the same |
| JP4810827B2 (en) * | 2002-08-21 | 2011-11-09 | 東レ株式会社 | Modified substrate and method for producing modified substrate |
| JPWO2004018085A1 (en) * | 2002-08-21 | 2005-12-08 | 東レ株式会社 | Modified substrate and method for producing modified substrate |
| JP2005334318A (en) * | 2004-05-27 | 2005-12-08 | Toyobo Co Ltd | High strength and high water permeability hollow fiber membrane type hemocatharsis apparatus |
| JP2006289071A (en) * | 2005-03-18 | 2006-10-26 | Toray Ind Inc | Sterilization method for compound |
| JP2006271430A (en) * | 2005-03-28 | 2006-10-12 | Toyobo Co Ltd | Method of sterilizing blood purifying module |
| EP1894965A4 (en) * | 2005-03-29 | 2008-06-18 | Toray Industries | Modified substrate and process for production thereof |
| EP3147315A1 (en) * | 2005-03-29 | 2017-03-29 | Toray Industries, Inc. | Modified substrate and process for production thereof |
| JP2007296145A (en) * | 2006-04-28 | 2007-11-15 | Toyobo Co Ltd | Blood purifier |
| JP2007301007A (en) * | 2006-05-09 | 2007-11-22 | Toyobo Co Ltd | Blood purifier |
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| Publication number | Publication date |
|---|---|
| JP2672051B2 (en) | 1997-11-05 |
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