JPH08277221A - Suppressant for alcohol absorption - Google Patents

Abstract

PURPOSE: To obtain the subject suppressant, containing caffeine as an active ingredient and capable of effectively suppressing the intracorporeal absorption of an alcohol contained in a liquor, etc., especially in the stomach and preventing unpleasant symptoms due to drinking. CONSTITUTION: This suppressant for alcohol absorption contains caffeine as an active ingredient so as to provide the caffeine within the range of 3-50mg based on 1kg body weight of a person ingesting the suppressant. When the caffeine is used with pectin, a milk fat and/or a dietary fiber in combination, the suppressing effects on the absorption of the alcohol can further preferably be enhanced. When a substance having promoting actions on alcoholic metabolism such as a saccharide, asparagine or vitamin C is added to the active ingredient, adverse effects due to drinking can further preferably be suppressed. Although the suppressant can be used as drinkables, the caffeine concentration can preferably be regulated to 0.05-5wt.% in this case.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an alcohol absorption inhibitor capable of effectively suppressing the absorption of alcohol contained in alcohol, whiskey, beer and the like in the body, particularly in the stomach.

[0002]

BACKGROUND OF THE INVENTION In order to suppress unpleasant symptoms such as nausea and other discomfort, nausea, vomiting, hangover or dizziness, which are harmful effects of drinking alcohol,
It is effective to suppress alcohol absorption in the body, especially in the stomach. As folk remedies, it is said from the old days that if you take milk fat such as milk before drinking alcohol, you will not get drunk, but because the ingested milk fat forms a film in the stomach, It is said that absorption of alcohol is suppressed.

Therefore, the present inventor has studied the components capable of effectively suppressing the absorption of alcohol in the body, particularly in the stomach, in particular, various components derived from natural products, and as a result, cafes contained in tea etc. The present invention has been accomplished by discovering that incin has an alcohol absorption suppressing action.

Regarding conventional caffeine, an invention in which caffeine is added to a drug or a quasi-drug by paying attention to its excitement-inducing action (Japanese Patent Application Laid-Open No. 4-32802, Japanese Patent Application Laid-Open No. 6-32802).
263648) and its peripheral nerve stimulating action, and invention added to a drug or quasi drug (JP-A-4-273).
814) and the like were disclosed, but the idea focusing on the alcohol absorption suppressing action of caffeine itself was not disclosed.

[0005]

In order to achieve the above object, the present invention features an alcohol absorption inhibitor containing caffeine as an active ingredient. If this alcohol absorption inhibitor is ingested, the excellent alcohol absorption suppressing effect of caffeine can effectively suppress the absorption of alcohol in the body, especially in the stomach. In the present invention, caffeine refers to caffeine or a mixture of caffeine and a caffeine derivative, that is, theophylline or theobromine.

The present invention also relates to caffeine, pectin,
It is also characterized by an alcohol absorption inhibitor containing, as an active ingredient, one of milk fat and dietary fiber or a mixture of any of these. All of the above-mentioned pectin, milk fat, and dietary fiber are components already known to have an alcohol absorption suppressing action, and the alcohol absorption suppressing effect can be further enhanced by adding these components to caffeine.

Further, in addition to the above-mentioned components of the present invention, substances known to promote alcohol metabolism such as fructose, pyruvic acid, L-cysteine, asparagine, serine, ornithine, alanine, arginine, vitamin C, aspartic acid and glutamic acid. If added, the alcohol absorption suppressing action and the alcohol metabolism promoting action work synergistically, and the harmful effects of drinking can be further suppressed.

The caffeine content in the present invention is about 0.5 mg to about 500 mg per kg body weight of the ingested person.
It is preferable to adjust the content to be within the range of, and it is particularly preferable to contain it in the range of about 3 mg to about 50 mg.
That is, for a person who takes caffeine, the weight is 1 kg.
It was found from the following animal administration test that an alcohol metabolism promoting effect can be obtained by ingesting about 0.5 mg or more per unit body weight, preferably about 3 mg or more per unit body weight, according to the Japanese Pharmacopoeia. About 500m
It is said that the amount is preferably g or less, particularly about 50 mg or less.

As the form of the alcohol absorption inhibitor of the present invention, fructose having an alcohol metabolism promoting action, SH amino acids such as L-cysteine, preferably sweeteners, flavors and the like are added to the above-mentioned active ingredient of the present invention, and oral administration is carried out. It may be in the form of a liquid, tablet, capsule, powder or the like which can be easily taken as an internal medicine, or it may be a drink. In this case, the caffeine concentration is preferably about 0 as a drinkable concentration. It is adjusted to about 0.05 to 5% by weight, and a sweetening agent, a flavoring agent, a preservative and the like are added thereto.

[0010]

【Example】

(Example 1: Mouse administration test) ICR male mice were used to divide these into three groups, and one group was orally administered with caffeine dissolved in physiological saline at a dose of 50 mg / kg per body weight (hereinafter, referred to as "mouse"). 50 mg of mice), and caffeine was added to the other group at 30 kg / kg of body weight.
Oral administration of 0 mg / kg (hereinafter,
1 hour later, each mouse was orally administered with 2 g (20% W / V) of ethanol per kg of body weight using a catheter. The above-mentioned caffeine is a commercially available product (manufactured by Wako Pure Chemical Industries,
The purity was 98.5%.

(Comparative) In addition, physiological saline alone was orally administered to the other group, and 1 hour later, the body weight was 1 kg.
2 g (20% W / V) of ethanol was orally administered using a catheter and used as a control.

(Measurement Method) For any mouse,
Immediately before the administration of ethanol, and 1 hour and 3 hours after the administration of ethanol, blood and stomach were collected, and the ethanol concentrations in blood and stomach were measured. The measuring method at this time is as follows.

Blood contained 0.5 ml of 30 mM thiourea.
And cooled 0.6N perchlo containing 0.1 mM EDTA
After adding ric acid (PCA reagent) and immediately mixing to remove proteins, this was centrifuged at 4 ° C. and 3000 rpm for 10 minutes. Then, the obtained supernatant fraction was used as a measurement sample. Stomach was frozen in liquid nitrogen immediately after excision and powdered using a mortar to 0.5 g
After adding and mixing ml of PCA reagent to remove protein,
This was centrifuged at 4 ° C. and 3000 rpm for 10 minutes as in the above blood, and the obtained supernatant fraction was used as a measurement sample. Then, 0.0004% t-butanol 0.1 ml was added as an internal standard substance to each of these measurement samples, and the mixture was adjusted to 1 at 65 ° C.
After heating for 5 minutes, this was injected into GC for quantitative analysis.

(Measurement Results) FIG. 1 shows the ethanol concentrations in the blood of 50 mg-administered mice, 300 mg-administered mice and controls obtained by the above-described measurement method, and FIG. 2 also shows 50 mg-administered mice, 300
It shows the ethanol concentration in the stomach in the mg-administered mouse and the control.

As a result, both the blood and gastric ethanol concentrations tended to reach a peak about 1 hour after ethanol administration in all mice. Therefore, considering the ethanol concentration 1 hour after ethanol administration, the blood ethanol concentration tended to be lower in the 50 mg-administered mouse and further in the 300 mg-administered mouse than in the control. Mice that received 50 mg compared to controls,
Furthermore, the value of 300 mg-administered mice tended to be high. Especially, the ethanol concentration in the stomach of the 300 mg-administered mice tended to be remarkably high. From this, it was found that the suppression of alcohol absorption by caffeine in the stomach.

Here, the effective amount of caffeine in the alcohol absorption inhibitor of the present invention is such that the effective amount of caffeine for humans is generally 100 minutes of the effective amount of animal test results from the precedents of clinical trials of pharmaceuticals. Assuming that about 1 is desirable, about 0.5 mg or more, preferably about 3 m, per 1 kg of body weight for the person who takes it.
It is sufficient to include g. In addition, the upper limit is set to an extreme amount of 500 mg per kg of body weight, preferably about 50 mg or less, based on the Japanese Pharmacopoeia.

Example 2 A drink formulation having the following formulation was prepared so that 100 mg of caffeine was contained in 100 ml of the total amount. Caffeine 100 mg Theanine 1000 mg Taurine 1000 mg Royal Jelly 200 mg Inositol 50 mg Nicotinamide 20 mg Vitamin B1 Sulfate 5 mg Vitamin B2 Phosphate 5 mg Vitamin B6 5 mg Purified Water Appropriate amount

Example 3 A drink formulation having the following formulation was prepared so that 100 mg of caffeine and 100 parts of pectin and dietary fiber were contained in a total amount of 100 ml. Caffeine 100 mg Theanine 1000 mg Taurine 1000 mg Royal Jelly 200 mg Inositol 50 mg Nicotinamide 20 mg Vitamin B1 Sulfate 5 mg Vitamin B2 Phosphate 5 mg Vitamin B6 5 mg Pectin 500 mg Dietary Fiber 1.3 g Purified Water Appropriate amount

Example 4 A drink formulation of the following formulation was prepared so that 100 mg of caffeine and 100 parts of aspartic acid and glutamic acid were contained in a total amount of 100 ml. Caffeine 100 mg Theanine 1000 mg Taurine 1000 mg Royal Jelly 200 mg Inositol 50 mg Nicotinamide 20 mg Vitamin B1 Sulfate 5 mg Vitamin B2 Phosphate 5 mg Vitamin B6 5 mg Aspartic Acid 120 mg Glutamic Acid 100 mg Purified Water Appropriate amount

[0020]

EFFECT OF THE INVENTION If the alcohol absorption inhibitor of the present invention is ingested before drinking alcohol, the alcohol absorption suppressing action of caffeine can suppress the absorption of alcohol in the body, especially in the stomach. Can prevent various unpleasant symptoms caused by drinking alcohol.

Further, when the alcohol absorption inhibitor of the present invention in which pectin, milk fat, dietary fiber and the like are added to caffeine, the alcohol absorption inhibitory effect of caffeine and the absorption of alcohol such as pectin, milk fat and dietary fiber are taken. The inhibitory action works synergistically to obtain a further alcohol absorption inhibitory effect, and it is possible to more reliably prevent unpleasant symptoms caused by drinking.

Since caffeine is a component contained in tea and coffee, which has been ingested in large amounts on a daily basis for a long time, its safety has been confirmed, and caffeine can be safely ingested and is available. Since it is easy to manufacture, it can be manufactured at low cost.

[Brief description of drawings]

FIG. 1 is a graph showing the time course of blood ethanol concentration in 50 mg / Kg mice, 300 mg / Kg mice and controls.

FIG. 2 is a graph showing the time course of gastric ethanol concentration in 50 mg / Kg mice, 300 mg / Kg mice and controls.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Shojiro Tsukamoto 4-31-36 Doshitada, Nerima-ku, Tokyo

Claims (2)

[Claims] 1. An alcohol absorption inhibitor containing caffeine as an active ingredient. 2. An alcohol absorption inhibitor containing caffeine as an active ingredient, which is obtained by adding any one of pectin, milk fat, and dietary fiber, or any combination thereof.