JPH08268878A - Peroral medicine and processed food - Google Patents

Abstract

PURPOSE: To remove pains in administering a peroral medicine and ingesting a processed food. CONSTITUTION: This peroral medicine is obtained by blending a pharmaceutical bulk or a substance having body temperature regulating functions or a nutrient therein, protecting the resultant medicine with a coating layer 3 having the proper elasticity and strength and adding the prepared medicine to a food material.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to oral medicines and processed foods, which are used in the medical or food industry.

[0002]

BACKGROUND OF THE INVENTION Oral pharmaceuticals include various agents such as capsules, pills, tablets, fine granules, granules, powders, troches and buccals as solid preparations, and syrups and drinks as liquid preparations. Taken in molds. Conventionally,
In order to make it easier to take, a method of providing an appropriate size or imparting a taste or a fragrance (for example, addition of sugar coating or a fragrance) has been used.

In the case of pediatric preparations, powders and liquids are the mainstream, part of tablets is crushed, part of capsules is opened and used as a powder for the preparation (Journal Journal, 583-). Page 587, Volume 30, Issue 2, 1994
Year).

Conventionally, many pharmaceutical additives used as coating agents in the formulation process have been developed and have already been industrially produced, and these are classified into gastric-soluble coating agents, enteric-coated coating agents and controlled-release coating agents. Yes (Pharmacia Review, No. 2)
2, pp. 75-81, 1987).

[0005]

Ease of administration is one of the important properties of oral pharmaceuticals. This property becomes more important in the case of pediatric drugs. Many children dislike taking oral medications. One of the causes of dislike taking the medicine is discomfort in the appearance, taste, aroma, texture, or texture of the oral medicine. Among the conventional oral medicines, there is a problem that it is difficult to take them due to the above-mentioned discomfort, or that there are many difficult ones to take. When a syrup and a solid preparation are mixed and used, there is a problem that it is difficult to stably maintain a constant dose due to a precipitate. There was also a problem that the tablets had to be crushed and the capsules had to be opened.

[0006] Foods processed using substances having a physical condition adjusting function (hereinafter referred to as functional foods: Pharmacia, pages 47 to 49, Vol. 31, No. 1, 1995) and nutrients such as vitamins and minerals. Foods with added (hereinafter referred to as fortified foods) are useful, but if the substances and nutrients to be added are easily decomposed or the flavor is extremely unpleasant, these processed foods that are easy to ingest by a simple addition method Was difficult to manufacture.

An object of the present invention is to solve the above-mentioned problems and to provide an oral drug which is easy to take and can reliably control a fixed dose, and a functional food or fortified food which is easy to take.

[0008]

[Means for Solving the Problems] In order to facilitate taking or ingesting, it can be taken or ingested by chewing like foods, and it should be in a form that does not release unpleasant taste and aroma components in the oral cavity. Ingenuity The drug was protected by an edible coating layer of appropriate elasticity and strength, and the drug was added to the foodstuff to find that it was suitable for the purpose, thus completing the invention.

[0009]

Action (a) The core A is a drug containing one or more drug bulk powders or substances or nutrients having a physical condition-regulating function. (B) One or more cores A are covered with an edible material having appropriate elasticity and strength, and the size is 5 m.
The particle B is m or less, preferably 1 mm or less. (C)
A predetermined number of one type or two or more types of particles B of one type or two or more types is included in foods such as confectionery. The present invention provides an oral pharmaceutical product and a processed food, characterized in that the food B such as confectionery contains the particles B coated with the edible material having the appropriate elasticity and strength as configured above. Is. In order to prevent decomposition of the bulk drug in the nucleus A or substances or nutrients having a physical condition-regulating function, mask the taste and aroma of the nucleus A, and prevent the nucleus A from being exposed in the oral cavity to be eluted in the stomach or intestine. Core A was coated with a gastric or enteric edible material. Furthermore, by imitating solid confectionery, it has become possible to easily take or ingest and reliably control a certain dose. Hereinafter, the configuration of the present invention will be described in detail.

There is no limitation on the bulk drug or the substance or nutrient having a physical condition adjusting function to be incorporated in the core A of the present invention. Examples of the bulk drug include, for neuropsychiatry, digestive organs, circulatory organ / blood, respiratory organs, urogenital organs,
Examples include bulk pharmaceutical powders for oral use that are used for various nutritional and tonic health products, for women, for allergies, and for otolaryngology. Substances that have a physical condition-regulating function include substances that have an immune-enhancing effect, substances that contribute to the prevention and recovery of diseases, substances that contribute to obesity prevention such as appetite suppressants, metabolic promoters, digestive enzyme inhibitors, hormone-like substances, etc. And those having a biological rhythm adjusting effect. Examples of nutrients include minerals such as calcium and iron, vitamins and the like. To the core A, one or more kinds of bulk drug or a substance or nutrient having a physical condition adjusting function is blended. The shape of the nucleus A is not limited.

One or more cores A are coated with an edible material of suitable elasticity and strength to give particles B of size 5 mm or less, preferably 1 mm or less. The shape of the particles B is not limited.

As the edible material forming the coating layer of the particles B, foods, food additives used in the food industry,
Examples include pharmaceutical additives used as coating agents and capsule bases in the formulation process. For example, the gastric-soluble edible material is typified by a cellulose ether derivative represented by hydroxypropylcellulose or hydroxypropylmethylcellulose, a polyvinyl derivative represented by polyvinyl acetal diethylaminoacetate, or a dimethylaminoethyl methacrylate / methyl methacrylate copolymer. Aminoalkyl methacrylic acid copolymer derivatives, sucrose, gelatin, etc., and enteric-coated edible materials include cellulose derivatives such as cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose, and methacryl. Methacrylic acid copolymer derivative represented by ethyl acrylate copolymer, Such Chin and chitosan. Examples of controlled release coatings, including but a combination of gastric or enteric coating agent and a water-insoluble polymer, not limited to the above.

The coating layer of the edible material of the particles B may be formed by a usual coating method. For example,
Examples include a method of spraying a solution of the edible material on the core A and a method of mixing the solution of the edible material and a paste with the core A, but are not limited to the above methods.

When two or more kinds of components are decomposed by mixing with each other, if they are blended in different cores A and coated with each other to form particles B, the decomposition can be prevented without contact.

The food containing the particles B is not particularly limited, but preferably solid, and more preferably those having a long shelf life and soft texture. Although the shape of the food is not limited, it is preferable that the shape of the food is not significantly different from the original shape. Examples include Western confectioneries such as chocolates, cakes, castellas, cream puffs, and Japanese confectionery such as kneaded products, sao products (yokan), rice cakes, and persimmon products, but are not limited to the above. Not done. The method of including the particles B in the food is not limited, but they are usually mixed in the course of the production of the food.

[0016]

The present invention will be described in detail with reference to the following examples.
These do not limit the scope of the invention.

Example 1 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug substances
A drug of m to 0.4 mm (corresponding to nucleus A) is mixed with an aqueous gelatin solution in a paste form, and molded into a plate having a thickness of 0.6 mm to 0.8 mm. After cutting this to a width of 0.6 mm to 0.8 mm, it is cut from 0.6 mm to 0.8 mm.
Particles B are obtained by cutting into a length of mm. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. Mix the required amount of melted chocolate and particles B,
Pour into a formwork, cool and harden.

Example 2 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug substances
A drug (corresponding to nucleus A) having a diameter of m to 0.4 mm is mixed with a gelatinous aqueous solution in a paste form, and the mixture has a diameter of 0.6 mm
It is extruded from a hole of 0.8 mm to form a thread. This is cut into a length of 0.6 mm to 0.8 mm to obtain particles B. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. The required amount of melted chocolate and particles B are mixed, poured into a mold, and cooled and solidified.

Example 3 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug powders
An aqueous suspension of hydroxypropylmethylcellulose acetate succinate and triethyl citrate is spray-coated onto a drug (corresponding to nucleus A) of m to 0.4 mm by spray gun. This is mixed with a pasty gelatin aqueous solution to form a plate having a thickness of 0.6 mm to 0.8 mm. After cutting this to a width of 0.6 mm to 0.8 mm, it is cut to a length of 0.6 mm to 0.8 mm,
Particle B is obtained. The particles B are sandwiched between rollers to be molded,
The core A on the cut surface may be coated. The required amount of melted chocolate and particles B are mixed, poured into a mold, and cooled and solidified.

Example 4 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug substances
An aqueous suspension of hydroxypropylmethylcellulose acetate succinate and triethyl citrate is spray-coated onto a drug (corresponding to nucleus A) of m to 0.4 mm by spray gun. This is mixed with a pasty gelatin aqueous solution, and this is extruded through a hole having a diameter of 0.6 mm to 0.8 mm to form a thread. This is cut into a length of 0.6 mm to 0.8 mm to obtain particles B. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. The required amount of melted chocolate and particles B are mixed, poured into a mold, and cooled and solidified.

Example 5 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug substances
An aqueous solution of hydroxypropylmethylcellulose and polyethylene glycol is spray-coated on a drug (corresponding to nucleus A) of m to 0.4 mm by spray gun.
This is mixed with a gelatinous aqueous solution in a paste form to a thickness of 0.
It is molded into a plate shape of 6 mm to 0.8 mm. 0.6
After cutting to a width of mm to 0.8 mm, it is cut to a length of 0.6 mm to 0.8 mm to obtain particles B. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. The required amount of melted chocolate and particles B are mixed, poured into a mold, and cooled and solidified.

Example 6 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug substances
An aqueous solution of hydroxypropylmethyl cellulose and polyethylene glycol is sprayed onto a drug (corresponding to nucleus A) of m to 0.4 mm by spray gun coating.
This is mixed with a pasty gelatin aqueous solution, and this is extruded through a hole having a diameter of 0.6 mm to 0.8 mm to form a thread. This is cut into a length of 0.6 mm to 0.8 mm to obtain particles B. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. The required amount of melted chocolate and particles B are mixed, poured into a mold, and cooled and solidified.

Example 7 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug powders
The drug with a sustained-release coating of m to 0.4 mm was mixed with a paste gelatin aqueous solution to give a thickness of 0.6.
It is molded into a plate shape of mm to 0.8 mm. 0.6m
After being cut to a width of m to 0.8 mm, a particle B is obtained by cutting to a length of 0.6 mm to 0.8 mm. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. The required amount of melted chocolate and particles B are mixed, poured into a mold, and cooled and solidified.

Example 8 Particle size of 0.1 m containing 1 or 2 or more kinds of bulk drug powders
A drug having a sustained-release coating of m to 0.4 mm is mixed with an aqueous gelatin solution in a paste form, and the mixture is extruded through a hole having a diameter of 0.6 mm to 0.8 mm to form a thread. This is cut into a length of 0.6 mm to 0.8 mm to obtain particles B. The particles B may be sandwiched between rollers and molded to cover the core A on the cut surface. Mix the required amount of melted chocolate and particles B, pour into a mold,
Chill and harden.

Example 9 A processed food in which one or more pharmaceutical bulk powders of Example 1 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 10 Processed food in which one or more pharmaceutical bulk powders of Example 2 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 11 A processed food in which one or more pharmaceutical bulk powders of Example 3 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 12 A processed food in which one or more pharmaceutical bulk powders of Example 4 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 13 A processed food wherein one or more pharmaceutical bulk powders of Example 5 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 14 A processed food in which one or more pharmaceutical bulk powders of Example 6 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 15 A processed food in which one or more pharmaceutical bulk powders of Example 7 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

Example 16 A processed food in which one or more pharmaceutical bulk powders of Example 8 are one or more nutrients such as vitamins and minerals or substances having a physical condition adjusting function.

[0033]

The oral medicine provided by the present invention is
In order not to damage the drug particles in the oral cavity, it contains what is coated with an edible material having appropriate elasticity and strength, and the appearance, taste, and aroma of solid confectionery that can be chewed and ingested in the oral cavity, It is easy to take because it has the same or similar texture or texture. Furthermore, since it is a solid preparation, it is possible to reliably control a fixed dose. Particularly in the case of pediatric preparations, crushing of tablets and opening of capsules can be avoided by adopting the present invention instead of relatively unsuitable tablets and capsules. In addition, decomposition of the bulk drug substance can be prevented by the coating.
Similarly, for functional foods and fortified foods, processed foods that are easy to ingest can be obtained even when substances and nutrients having a physical condition-regulating function are easily decomposed or the flavor is extremely unpleasant.

The gist of the present application is to eliminate the pain when taking a drug. Whether or not the therapeutic effect is medically proven should belong to future problems and should not be the main point of the present application. However, the disintegration of gastric-soluble edible materials in the stomach and the disintegration of enteric-soluble edible materials in the intestine are fundamental to pharmaceutics. Therefore,
The core A is selectively released in the stomach or intestine unless the coating layer of particles B is damaged in the oral cavity. In the next step, it is easily conceivable that the drug in the nucleus A will be eluted and absorbed.

[Brief description of drawings]

FIG. 1 is a perspective view of the present invention.

FIG. 2 is a sectional view taken along line a of FIG.

[Explanation of symbols]

 1 is an edible material such as chocolate 2 is a particle B 3 is a coating layer 4 is a core A

Claims (3)

[Claims] 1. (a) A drug containing one or more kinds of bulk drug substances as the core A. (B) One or two or more cores A are coated with an edible material to obtain particles B having a size of 5 mm or less, preferably 1 mm or less. (C) One or two particles B of one kind or two kinds or more
A predetermined number of pieces or more is included in food such as confectionery. Easy-to-administer oral drug with the above composition 2. The edible material is (1) a cellulose ether derivative represented by hydroxypropylcellulose or hydroxypropylmethylcellulose, a polyvinyl derivative represented by polyvinyl acetal diethylaminoacetate, or a dimethylaminoethyl methacrylate / methyl methacrylate copolymer. When it is a gastric-soluble edible material such as aminoalkyl methacrylic acid copolymer derivative represented by, sucrose, and gelatin, or
(2) Cellulose acetate phthalate, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethyl ethyl cellulose and other cellulose derivatives, methacrylic acid copolymer derivatives typified by ethyl methacrylic acid acrylate copolymer, and enteric-soluble such as chitin and chitosan. The oral pharmaceutical product according to claim 1, which is an edible material or (3) a controlled release coating agent such as a combination of a gastric or enteric coating agent and a water-insoluble polymer. 3. One or two of claim 1 or claim 2.
Processed food in which one or more pharmaceutical bulk powders are one or more nutrients such as vitamins and minerals or substances having a physical condition regulating function