JPH08266589A - Blood bag - Google Patents

Abstract

PURPOSE: To make it efficiently execute the operation to remove leukocytes by segmenting the inside of a blood bag to a blood inflow chamber and a blood housing chamber and providing this bag with a leukocyte cell removing filter for removing the leukocytes from the blood, thereby preventing the blood from stagnating in the respective parts. CONSTITUTION: The part between the second and third sheets 10 and 11 of the main body 2 of the blood bag 1 is formed as the second blood housing chamber 18 in which the blood subjected to the removal of the leukocytes is housed. The central part in the width direction of the first and second sheets 9, 10 is welded in the vertical direction and the left side part of the first and second sheets 9, 10 is formed as an air housing chamber. The leukocyte removing filter 3 is disposed in the lower part on the right side between the first and second sheets 9, 10 and its peripheral edge is welded to the first and second sheets 9, 10. The right side part between the first and second sheets 9, 10 is segmented to a blood inflow chamber 17 into which the blood flows from outside and the first blood housing chamber 13 which exists in the lower part.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a blood bag.

[0002]

2. Description of the Related Art In recent years, whole blood samples have been treated with plasma preparations,
Processed into three blood components, platelet products and red blood cell products,
Ingredient transfusion, in which only the blood components required by the patient are transfused, is widespread. For component transfusion, it is necessary to remove blood components from a whole blood sample and aseptically prepare the above blood product for transfusion. At the time of this preparation, for example, a blood bag set is used. This set consists of a blood collection needle, a blood collection blood bag filled with anticoagulant, and a blood bag for component separation. Each blood bag is a flexible plastic material suitable for storing blood components. The container is made of. The blood collection needle and the blood collection blood bag are connected by a blood transfer tube, and the blood transfer tube connected to the upper part of the blood collection blood bag is connected to the component separation blood bag.

When preparing a blood product with a blood bag set, first, a whole blood sample is collected in a blood bag for blood collection, and then the blood bag set is placed in a centrifuge to centrifuge the whole blood sample. To do. As a result, in the blood bag for blood collection, the layers containing plasma, platelets, white blood cells, and red blood cells are formed separately in the above order from top to bottom due to the difference in specific gravity. After centrifugation, the plasma and platelets in the blood collection blood bag are transferred to the component separation blood bag via the blood transfer tube, and the red blood cells are left in the blood collection blood bag for storage.

However, in the above-mentioned preparation method, the white blood cells in the intermediate layer in the blood collecting blood bag may be mixed with each blood component, which may cause side effects of blood transfusion. Therefore, there is a demand for the removal of white blood cells from a whole blood sample or each blood component. Washed red blood cell method, thawed red blood cell method, and white blood cell removal filter method are known as methods for removing white blood cells in blood. Among them, the white blood cell removal filter method, which is easy to operate and has a high white blood cell removal rate, is widely used. are doing.
As the filter method, there is one disclosed in Japanese Patent Application Laid-Open No. 6-335516. In this, a leukocyte removal filter is provided inside or outside the blood collection blood bag, and the blood in the blood collection blood bag is supplied to the leukocyte removal filter via the blood transfer tube to remove leukocytes. The blood is supplied to the component separation blood bag via the blood transfer tube.

[0005]

In the above prior art,
The blood transfer path during the white blood cell removal work is a blood collection blood bag → a blood transfer tube → a leukocyte removal filter → a blood transfer tube → a blood bag for component separation, which is extremely long, so that blood easily stays in each part, There is a problem that the work of removing white blood cells cannot be performed efficiently. Further, in the above-mentioned conventional technique, two blood bags and two blood transfer tubes are required, and there is a problem that the structure is complicated and the cost is high. Furthermore, although air is present in the leukocyte removal filter, this air mixes with the blood from which leukocytes have been removed, and in this state, blood is processed and stored, so each blood component There was also a problem that it was not practical because it adversely affected the function and storage conditions of. An object of the present invention is to provide a blood bag that can solve the above problems.

[0006]

In order to solve the above-mentioned problems, the blood bag of the present invention is characterized by a blood inflow chamber into which blood flows from the outside,
The point is that a blood storage chamber that stores blood from which white blood cells have been removed, and a white blood cell removal filter that separates the blood inflow chamber and the blood storage chamber and removes white blood cells from the blood are provided. It should be noted that an air removing means for removing the air in the blood chamber may be provided. In addition, the air removing means is A. An air storage chamber provided in the blood bag for storing air; An air transfer path connecting the blood storage chamber and the air storage chamber; It may have a shutoff means for shutting off the air transfer path so that they can communicate with each other.

[0007]

[Function] When blood is supplied to the blood inflow chamber of the blood bag,
The supplied blood passes through the leukocyte removal filter,
After the white blood cells are removed, the blood is stored in the blood storage chamber in the blood bag. When removing the air in the blood chamber, the shut-off means is operated to bring the air transfer path into communication. next,
The blood storage chamber is pressed by a hand or the like to push out the air accumulated on the upper side thereof, and the air is transferred to the air storage chamber via the air transfer path.

[0008]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A first embodiment of the present invention will be described below with reference to the drawings of FIGS. 1 to 3 show a blood bag 1, which has a main body 2, a leukocyte removal filter 3, a blood supply tube 4, a support 5, an air removal means 6, a blood transfusion connection portion 7 with a protector, and the like. . The main body 2 is composed of three first to third sheets 9 to 11 made of a flexible material, and synthetic resin is used as the flexible material. As the synthetic resin, a thermoplastic resin such as polyvinyl chloride, polyethylene or polypropylene is used. The periphery of the first to third sheets 9 to 11 is welded (sometimes referred to as adhesion. The same applies hereinafter) 12, and the blood from which the white blood cells have been removed is accommodated between the second and third sheets 9 and 10. The second blood storage chamber (secondary blood storage chamber, final blood storage chamber, or rear blood storage chamber) 18 is used as the second blood storage chamber. First and second sheets 9,1
The central portion in the width direction of 0 is welded over the entire length in the vertical direction.
The space between the left sides of the first and second seats 9 and 10 is an air storage chamber 15 in which air is stored.

Leukocyte removal filter (blood filtering material) 3
Is for removing leukocytes from blood, and a porous fiber material is used, but other porous materials such as non-woven fabric may be used. The white blood cell removal filter 3 is the first
The lower portion of the right side portion between the second seats 9 and 10 or the central portion in the up-down direction, and the peripheral portion is the first and second seats 9 and 1.
No. 0, the right side portion between the first and second sheets 9 and 10 is located on the upper side and the blood inflow chamber 17 at which blood flows in from the outside, and the first blood storage chamber (the first blood storage chamber located on the lower side) Next blood storage chamber, temporary blood storage chamber, pre-stage blood storage chamber, or blood outflow chamber) 13. When used, the leukocyte removal filter 3 is inclined with respect to the front-rear direction, so that the blood passage area is larger than the cross-sectional area of the blood inflow chamber 17 or the first blood storage chamber. . As a result, leukocytes can be removed efficiently. In the portion of the second sheet 10 that forms the wall portion of the first blood storage chamber 13, a vertical slit 19 that connects the first blood storage chamber 13 and the second blood storage chamber 18 is provided over the entire length in the vertical direction. Has been formed.

The blood supply tube 4 is for supplying blood to the blood inflow chamber 17 from the outside, is inserted into the blood inflow chamber 17 from above, and when the peripheral portions of the first to third sheets 9 to 11 are welded, It is welded to the first and second sheets 9 and 10. The blood supply tube 4 is made of the same synthetic resin as the first to third sheets 9 to 11, and the lower end portion (insertion portion) thereof is bent rearward and is provided along the first sheet 9. Support 5
Is made of the same synthetic resin as the first to third sheets 9 to 11, has a round bar shape, and is vertically arranged in the blood inflow chamber 17. The support 5 is provided on the second sheet 10,
It is welded to the portion of the blood inflow chamber 17 that constitutes the wall portion and cooperates with the lower end of the blood supply tube 4 to prevent the leukocyte removal filter 3 from coming into close contact with the second sheet 10. As a result, the function of the leukocyte removal filter 3 is unlikely to be hindered.

The air removing means 6 includes the air containing chamber 15
And an air transfer path 21 that connects the second blood storage chamber 18 and the air storage chamber 15, and a bent rod 22 that disconnects the air transfer path 21 so that they can communicate with each other. The air transfer path 21 includes a cylindrical air transfer connection portion 24 and an air transfer tube 25.
These are made of the same synthetic resin as the first to third sheets 9 to 11. The air transfer connection portion 24 is disposed between the upper ends of the left side portions of the second and third seats 10 and 11, and the first to third
When the peripheral portions of the sheets 9 to 11 are welded, they are welded to the second and third sheets 10 and 11. One end of the air transfer tube 25 is welded to the air transfer connection part 24, and the other end thereof is disposed between the left upper ends of the first and second sheets 9 and 10, and the first to third parts are provided. When the peripheral portions of the sheets 9 to 11 are welded, they are welded to the first and second sheets 9 and 10.

The folding bar 22 is an example of a blocking means, and is made of a hard synthetic resin such as polycarbonate.
It is made of polyvinyl chloride, polystyrene, polyethylene terephthalate, or the like. As shown in FIG. 4, the bent bar 22 is
It is composed of a communicating cylinder 27, a thin portion 28, and a bent rod portion 29 which are continuously provided in the axial direction. The communication cylinder 27 is hollow and is inserted into the air transfer connection portion 24, and is closely attached to the inner surface of the air transfer connection portion 24 and held by the connection portion 24. Thin part 2
The wall thickness of 8 is smaller than that of the communication cylinder 27 and the bent rod portion 29. The bent rod portion 29 closes the tip end opening portion of the communication cylinder 27. The blood transfusion connection portion 7 includes the first and second sheets 9,
The first and second sheets 9 and 1 are disposed between the upper ends of the right side of the first and second sheets 10 and 10 when the peripheral portions of the first to third sheets 9 to 11 are welded.
It is welded to zero.

According to the above-described embodiment, when the blood bag 1 is used as a blood collecting blood bag, a blood collecting needle is provided at the tip of the blood supply tube 4 and the second blood storage chamber of the blood bag 1 is provided in advance. 18 and the like are filled with an anticoagulant solution.
Then, blood collected from the donor (whole blood sample) is supplied to the blood inflow chamber 17 via the blood supply tube 4. The supplied blood passes through the leukocyte removal filter 3 to remove leukocytes, then flows into the first blood storage chamber 13, and then through the slit 19, the second blood storage chamber 1
It is housed in 8. The blood from which white blood cells have been removed
There are two types of cases, that is, the case where the blood is stored only in the blood storage chamber 18 and the case where the blood is stored in both the first and second blood storage chambers 13 and 18. As described above, the blood supplied to the blood inflow chamber 17 is simply transferred in the blood bag 1 to remove leukocytes, and the blood transfer path at that time is extremely short. Therefore, blood does not stay, and leukocyte removal work can be performed efficiently.

Since leukocytes can be removed only within the blood bag 1, the structure is simple and the cost is low. By the way, since air is present in the leukocyte removal filter 3, the air is removed from the second blood together with the blood when the leukocytes are removed.
The blood is transferred into the blood chamber 18. Therefore, in order to remove the air in the second blood storage chamber 18, the bent rod 22 is bent together with the air transfer connecting portion 24 and is folded at the thin portion 28,
The air transfer path 21 is brought into communication. Next, the second blood storage chamber 18 is squeezed by a hand or the like, and the air accumulated on the upper side thereof is pushed out, and the air is transferred to the air storage chamber 15 via the air transfer connection portion 24 and the air transfer tube 25. Transfer to. Then, the end portion of the air transfer tube 25 on the air transfer connection portion 24 side is melt-cut to seal the end portion.

As described above, since the air in the second blood storage chamber 18 can be removed, when processing or storing the blood in the second blood storage chamber 18 or the first blood storage chamber 13, Air does not adversely affect the functions and storage conditions of each blood component, and is practically excellent. When removing blood components such as plasma, platelets, and red blood cells from blood from which white blood cells have been removed, the blood bag 1 is placed in a centrifuge, the blood is centrifuged, and the blood transfusion connection portion 7 is used. , Plasma and platelets may be taken out in the same manner as in the past. The blood inflow chamber 17
Instead of whole blood sample, centrifuged plasma,
Blood components of either platelets or red blood cells may be supplied. In addition, although the bent bar 22 is used in the first embodiment,
Instead, the air transfer tube 25 is connected to the tube 2
A clamp may be provided to shut off 5 so that it can communicate.

FIG. 4 shows a second embodiment of the present invention, in which the air removing means is omitted from the first embodiment. In this embodiment, the space between the left side portions of the first and second sheets 9 and 10 is not the air storage chamber but the preliminary chamber, but is the third blood storage chamber communicating with the second blood storage chamber 18. In some cases.

[0017]

As described in detail above, according to the present invention,
The white blood cells can be removed from the blood, the blood does not stay when the white blood cells are removed, the removal work can be performed efficiently, and the structure is simple and the cost is low. According to claim 2,
Since air can be removed from the blood storage chamber in which the blood from which white blood cells have been removed is stored, the air is unlikely to adversely affect the functions and storage conditions of each blood component.

[Brief description of drawings]

FIG. 1 is a partial cross-sectional front view of a blood bag according to a first embodiment of the present invention with the second and third sheets removed.

FIG. 2 is a sectional view taken along line AA of FIG.

FIG. 3 is a sectional view taken along the line BB of FIG.

FIG. 4 is a partial cross-sectional view of a bent rod and the like showing the first embodiment of the present invention.

FIG. 5 is a partial cross-sectional front view of the blood bag according to the second embodiment of the present invention with the second and third sheets removed.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Blood bag 3 Leukocyte removal filter 6 Air removal means 13 1st blood storage chamber 15 Air storage chamber 17 Blood inflow chamber 18 2nd blood storage chamber 19 Slit 21 Air transfer path 22 Broken bar (blocking means)

Claims (3)

[Claims] 1. A blood bag, a blood inflow chamber into which blood flows from the outside, a blood storage chamber in which blood from which white blood cells have been removed are stored, and a blood inflow chamber and a blood storage chamber are defined, and blood is separated from the white blood cells. A blood bag having a white blood cell removal filter for removing blood. 2. The blood bag according to claim 1, further comprising air removing means for removing air in the blood chamber. 3. The air removing means comprises: An air storage chamber provided in the blood bag for storing air; and B. An air transfer path connecting the blood storage chamber and the air storage chamber; The blood bag according to claim 2, further comprising a shutoff unit that shuts off the air transfer path so that the air transport path can communicate with the air bag.