JPH08245401A - Skin protecting agent - Google Patents

Abstract

PURPOSE: To obtain a skin protecting agent simply usable, excellent in treating effect and hardly having adverse effect. CONSTITUTION: This skin protecting agent contains a complex agent obtained by mutual action of chitosan on an organic acid as an active ingredient and the complex agent is used in a state of an aqueous solution.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin protectant containing a composite agent of chitosan and an organic acid as an active ingredient, and more specifically, it has macrophage activating ability and has a wound healing effect, an analgesic effect and an anti-effect. The present invention relates to a skin protective agent that exerts an inflammatory effect and the like and has a preferable effect on wound surfaces and inflammatory skin diseases such as eczema and atopic dermatitis.

[0002]

2. Description of the Related Art Various healing agents have been developed for the purpose of promoting wound healing, and many materials have been proposed and commercialized.

Materials for wound healing promoters are classified into those composed mainly of synthetic products and those composed mainly of natural products. Materials made of synthetic materials include nylon fibers, polyester fibers, polyurethane, and crosslinked polyvinyl alcohol, and materials made of natural materials include collagen, pig skin, and fibrin membrane.

A number of drugs have been developed as anti-inflammatory agents and are actually used for treatment. Typical examples thereof include corticosteroids (steroids) and non-steroid external preparations, which are usually used in the form of ointments or creams.

Chitin and chitosan, which can be used for the above-mentioned materials for wound healing and inflammatory dermatitis, are provided as powder, sheet-like or sponge-like molded articles.

[0006] However, since the above-mentioned conventional wound healing promoters and anti-inflammatory agents based on the above-mentioned materials are intended for the medical doctor, they cannot be used very easily, and their therapeutic effects are not always satisfactory, and steroids are not always satisfactory. May have side effects.

[0007]

SUMMARY OF THE INVENTION Therefore, the present invention
An object of the present invention is to provide a skin protective agent which can be easily used, has an excellent therapeutic effect, and has few side effects.

[0008]

Means for Solving the Problems The inventors of the present invention have conducted extensive studies to solve the above problems, and as a result, use a composite agent obtained by interacting chitosan with an organic acid as an active ingredient.
The inventors have found that by using the complex agent in the form of an aqueous solution and spraying it on the wound surface and the inflamed surface, excellent wound healing and anti-inflammatory effects are exhibited and the present invention has been completed.
According to this skin protectant, it can be used easily, has an excellent therapeutic effect, and has almost no side effects.

The composite agent is dried into a powder state,
When used, the complexing agent can also be carried out in the form of an aqueous solution.

[0010]

The present invention has the following actions.

The chitosan used in the present invention is contained in crustaceans such as shrimp and crab, insects such as grasshopper and beetle, and squid crustaceans, and is widely distributed in nature.
It is poly-N-acetyl-D-glucosamine obtained by deacetylating a polysaccharide composed of (1,4) -bonded poly-D-glucosamine.

[0012] Chitosan has a property of permeating water and low molecular weight substances, has an excellent anticoagulant property, has a good affinity with living tissues, does not cause a tissue reaction, and has a performance as a living substance. , Is being applied to various medical materials.

In the present invention, the organic acid is allowed to interact with chitosan because the organic acid is bound to chitosan to form a quaternary ammonium salt, which is soluble in water and the aqueous solution is cationically charged. Therefore, the film formation and affinity to the anion-charged skin are good. In addition, since the organic acid salt of chitosan has an antibacterial action against microorganisms, there is an advantage that it is safe against infectious diseases. As the organic acid, for example, lactic acid, acetic acid, ascorbic acid or the like can be used.

As in the present invention, when a drug is used in the form of an aqueous solution and sprayed on the wound surface or the inflamed surface, the drug is formed and compared with a treatment method for protecting the wound surface or the inflamed surface in the form of sheet, film or powder. It is easy to apply and can be applied evenly and over a wide area, so it is highly reliable.

In particular, when a spraying agent containing a complexing agent of the present invention obtained by interacting chitosan with an organic acid as an active ingredient is used in the form of an aqueous solution, a treatment method (the number of spraying or Since it is possible to adjust the amount) at any time and to observe the wound surface and the inflamed surface under direct vision, there are many advantages such as accurate prognosis determination.

[0016]

EXAMPLES Examples of the skin protectant of the present invention will be described below.

In this example, a skin protectant was prepared as follows. A complexing agent is obtained by dissolving chitosan in an aqueous solution of an organic acid such as lactic acid, acetic acid, or ascorbic acid and allowing them to interact with each other. This composite agent is filtered and dried,
Used as a raw material for skin protectants. When this raw material is dissolved in water,
It can be used as a skin protectant.

The organic acid to be used is not limited to lactic acid, acetic acid, ascorbic acid, etc., and any generally used and safe organic acid may be used. Also, the viscosity, deacetylation degree, and molecular weight of chitosan are not particularly limited.

A more specific embodiment will be described below. (Example 1) Chitosan powder (manufactured by Yaegaki Fermentation Giken) 10
0 g was added to 5000 mL of water, stirred and suspended for 10 minutes, added to 50 mL of acetic acid, and further stirred and dissolved for 3 hours. The obtained aqueous solution was subjected to suction filtration with a 0.45 μm membrane filter. Next, this solution was sterilized in an autoclave (121 ° C, 15 minutes). The sterilized solution was freeze-dried to obtain a pale yellow powder. (Example 2) Chitosan powder (manufactured by Yaegaki Fermentation Giken) 50
g was added to 5000 mL of water, stirred and suspended for 10 minutes, added to 50 mL of lactic acid, and further stirred and dissolved for 3 hours. The obtained aqueous solution was subjected to suction filtration with a 0.45 μm membrane filter, and white powder was obtained by the same operation as in Example 1. (Example 3) Chitosan powder (manufactured by Yaegaki Fermentation Giken) 10
g was added to 1000 mL of water, and 12 g of ascorbic acid was added, and the same operation was performed to obtain a white powder.

Next, examples of use of each of the above skin protecting agents will be described. (Use Example 1) On a whole body of a two-year-old infant with atopic dermatitis,
The composite agent of Example 1 was dissolved in water (0.13% concentration) and applied once a day. Also, the severely pruritic areas were applied several times. As a result, the eczema part disappeared after about 3 months. During this period, steroid ointment was not used. (Use Example 2) The composite agent of Example 2 was dissolved in water (0.13% concentration) and applied by spraying to the affected area of a 37-year-old woman having symptoms of razor loss, makeup loss, and rough skin. The result was completely cured. (Use Example 3) The complex agent of Example 3 was applied as it was to the affected area of a 65-year-old man who had his finger pierced with a flea. The result was completely cured. (Use Example 4) The combined preparation of Example 1 was dissolved in water (0.13%) to the affected area of a 57-year-old man who had a bleeding symptom due to bruise on the face.
Concentration) and applied by spraying. The result was completely cured in a week. (Use Example 5) The composite agent of Example 2 was dissolved in water (0.13% concentration) and applied by spraying to the affected area of a 58-year-old man who had symptoms of low-temperature burn. The result was completely cured in a week. (Use Example 6) The composite agent of Example 3 was dissolved in water (0.13% concentration) and applied by spraying to the affected area of a 10-year-old girl with atopic dermatitis. As a result, the symptoms were alleviated in 3 months.

The skin protectant of each of the above examples showed an excellent healing effect on wounds and inflammatory skin diseases. Also,
Since no side effects were observed, it could be used with confidence, and the state of the affected area could be visually confirmed, which was very effective.

[0022]

The present invention having the above-mentioned structure has the following effects.

[0023] Easy to use and excellent in therapeutic effect,
In addition, it is possible to provide a skin protective agent with few side effects.

Claims (2)

[Claims] 1. A skin protective agent comprising a composite agent obtained by interacting chitosan and an organic acid as an active ingredient, and using the composite agent in the form of an aqueous solution. 2. The composite agent is dried into a powder state,
The skin protective agent according to claim 1, wherein the composite agent is brought into an aqueous solution state when used.