JPH0823941A - Healthy beverage - Google Patents

Abstract

PURPOSE:To obtain a healthy beverage, containing a diglyceride and capable of utilizing and promoting the utilization of fats in the body during the motion. CONSTITUTION:This healthy beverage contains about >=0.01wt.%, preferably 1-10wt.% diglyceride. The diglyceride is a preferably a diester of a 6-22C (especially 14-22C) saturated or unsaturated fatty acid with glycerol. In the case of a mixture of the diglyceride with a monoglyceride or a triglyceride, >=50wt.% thereof in the whole glyceride is preferably the diglyceride.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health drink that promotes the action of using fat in the body as an energy source during exercise.

[0002]

2. Description of the Related Art Conventionally, many health drinks, especially drinks for the purpose of supplementing energy during sports, have been developed. For example, there is Energen (Otsuka Pharmaceutical Co., Ltd.) and the like, which is for the purpose of energy supply during endurance exercise. The energy required for exercise is mainly supplied by sugars and fats stored in the body. Of these two energy sources, sugar is used for a short period of rapid exercise, and fat is used for endurance exercise. In sports, it is important to effectively use the fat held in the body to maintain endurance.

By the way, the main body of fat, which is important as an energy source, is triglyceride, and the triglyceride ingested or accumulated in the body is decomposed into fatty acid, and then metabolized by the citric acid cycle via acetyl CoA. If the balance between this fatty acid metabolism and fat intake is good,
It is considered that there is no excessive accumulation of fat in the body and lack of energy during exercise.

On the other hand, the ketone body is a general term for acetoacetic acid, β-hydroxybutyric acid and acetone. These groups of compounds produce acetyl-CoA mainly by β-oxidation of fatty acids in the liver, but when the amount of acetyl-CoA from fatty acids becomes excessive, fasting, diabetic, etc., the availability of sugar in the body is reduced. Sometimes increases. It is known that the number of ketone bodies increases even when the TCA cycle is decreased in glucose metabolism, even when the condition is not pathological. The generated ketone bodies are also used as an energy source in the heart and skeletal muscle when energy is needed. Therefore, it is considered that a substance having an action of increasing blood ketone bodies when energy is needed promotes utilization of fat accumulated in the body and is useful as a component of a health drink.

[0005]

SUMMARY OF THE INVENTION It is therefore an object of the present invention to provide a health drink that promotes the use of fat in the body when energy is needed.

[0006]

Therefore, as a result of various studies on the relationship between the intake of fat and the excretion of ketone bodies in the urine, the present inventors have surprisingly found that diglycerides are more active in the body during exercise, which requires more energy than triglycerides. It has been found that it has an action of promoting the use of fat accumulated in the above, and has completed the present invention.

That is, the present invention provides a health drink containing diglyceride.

The diglyceride used in the present invention, that is, glycerin diester of fatty acid, has 6 to 6 carbon atoms.
It is preferably a diester of a saturated or unsaturated fatty acid having 22 (particularly, 14 to 22 carbon atoms) and glycerin. Examples of saturated fatty acids having 6 to 22 carbon atoms include lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, and behenic acid. Examples of unsaturated fatty acids having 6 to 22 carbon atoms include palmitooleic acid, oleic acid, elaidic acid,
Mention may be made of isooleic acid, petroselinic acid, erucic acid, linoleic acid and linoleic acid.

The diglyceride used in the present invention preferably has a fatty acid composition containing a large amount of unsaturated fatty acid components. That is, in the diglyceride of the present invention, the unsaturated fatty acid groups preferably account for 70% by weight or more of the total fatty acid groups, and particularly preferably 80% by weight or more. And it is desirable that most of the diglycerides are diunsaturated fatty acid glycerides. In the present invention, the diglyceride may be used alone, but since it is not industrially easy to isolate the diglyceride, it may be used as a mixture with a monoglyceride or a triglyceride. However,
In that case, it is desirable that 50% by weight or more of all glycerides is diglycerides.

The diglyceride preferably used in the present invention includes, for example, fats and oils having a large content of unsaturated fatty acid groups (eg, safflower oil, olive oil, cottonseed oil, corn oil, rapeseed oil, soybean oil, palm oil, sunflower oil, sesame oil). ;
Lard, beef tallow, fish oil, milk fat, or fractionated oils thereof,
One or more kinds of fats and oils selected from randomized oils, hydrogenated oils, transesterified oils) and glycerin are transesterified in the presence of a hydroxide of an alkali metal or an alkaline earth metal, or It can be obtained by an esterification reaction of a fatty acid mixture having a high unsaturated fatty acid content derived from fats and oils and glycerin. The excess monoglyceride produced by the reaction can be removed by using a separation means such as a molecular distillation method or chromatography. Although these reactions can be carried out by a chemical reaction using an alkali catalyst as described above, it is better to carry out the reaction under mild conditions using an enzyme such as a 1,3-position selective lipase. The obtained diglyceride has a good flavor and is preferable.

The diglyceride used in the present invention can also be obtained by fractionating natural edible oils and fats.

The oral acute toxicity of these diglycerides in rats is 10 g / kg body weight or more, which is highly safe.

The blending amount of diglyceride in the health drink of the present invention is not particularly limited, but is preferably 0.01% by weight or more, more preferably 0.01 to 30% by weight, and 1 to 10%.
Weight percent is particularly preferred.

In addition to diglycerides, the health drink of the present invention contains ingredients that can be added to ordinary soft drinks, for example, sweeteners such as sugar, fructose, glucose and liquid sugar, salt, potassium chloride,
Minerals such as magnesium chloride, vitamins, organic acids such as citric acid, malic acid, tartaric acid, amino acids and the like can be added, but the present invention is not limited thereto.

[0015]

The present invention will be further described with reference to examples, but the present invention is not limited thereto.

The diglyceride used in each of the following examples is
It is manufactured by the following method. 860 g of rapeseed oil-derived fatty acid having a fatty acid composition of Table 1 and 140 g of glycerin, using a commercially available lipase preparation (Novo Industri AS Co., trade name: Lypozyme 3A) that is an immobilized 1,3-position selective lipase as a catalyst. Was reacted at 40 ° C. After the reaction, the lipase preparation is filtered off, and the reaction product is subjected to molecular distillation and purified by a conventional method to obtain 80% by weight of diglyceride, 18% by weight of triglyceride and 2% by weight of monoglyceride in which most of the fatty acid groups are unsaturated fatty acids. % Glyceride mixture was obtained. The amount of diglyceride used below is the amount of this mixture used.

[0017]

[Table 1]

The triglyceride used in each of the following examples is a rapeseed oil having the same fatty acid composition as above.

Example 1 A. Test method (1) According to the schedule shown in Table 2, 11-week-old SD male rats (180 to 182 g) were fed with a diet containing 20% of diglyceride and triglyceride for 1 week, in the blood and
The ketone bodies in urine were measured.

[0020]

[Table 2]

(2) Further, as a model of a high energy utilization state, a comparative study was carried out with respect to a model in which exercise is applied and a model in a normal energy utilization state without exercise.
As for the exercise load, a forced exercise was applied using a treadmill (Natsume Seisakusho) according to the schedule shown in Table 3.

[0022]

[Table 3]

The feed composition used in the diet is shown in Table 4.

[0024]

[Table 4]

* 1, * 2: AIN86 blended * 3: 2 to match the amount of triglyceride and fatty acid
It was 1.0%.

The blood and urine ketone body concentrations are measured by a clinician, vol. 9, special issue 1811-1814 and Clinica Chimica
aAct), 134; 327-336.

B. Test results The results are shown in Tables 5-8.

[0028]

[Table 5]

From Table 5, the exercise load group showed lower body weight and organ weights than the non-exercise group, but no difference was observed between the diglyceride administration group and the triglyceride administration group.

[0030]

[Table 6]

From Table 6, the amount of food intake in the exercise load group was lower than that in the non-exercise group, but no difference was observed between the diglyceride administration group and the triglyceride administration group.

[0032]

[Table 7]

From Table 7, the amount of ketone bodies in blood increased by exercising, but no difference was observed between the diglyceride administration group and the triglyceride administration group.

[0034]

[Table 8]

From Table 8, no difference in the amount of ketone bodies in blood was observed between the exercise load group and the non-exercise group.
On the other hand, the amount of urinary ketone bodies in the exercise-loaded group was significantly lower in the diglyceride-administered group than in the triglyceride-administered group. In the non-exercise group, the diglyceride administration group showed a significantly higher value than the triglyceride administration group.

From Tables 5 to 8, there was no difference in the amount of ketone bodies in the blood of rats not subjected to exercise, but the amount of excreted ketone bodies in the urine was high on the diglyceride diet. . This means that diglyceride is dietary or
Converts fatty acids derived from body fat into ketone bodies, excreted in urine,
It shows that the body accumulation of fat is suppressed. In exercise-treated rats, urinary ketone bodies were lower in the diglyceride group than in the triglyceride group. On the other hand, blood ketone bodies increased after exercise in both the diglyceride diet group and the triglyceride diet group, and the values were not different between both diet groups. It is considered that this is because diglycerides use the fat in the body as an energy source during exercise, and at the same time, the ketone bodies produced from the diglycerides are also used as an energy source, and the excretion of ketone bodies in urine is reduced. That is, even during exercise, diglyceride utilizes fatty acids in the body to suppress accumulation in the body.

Example 2

[0038]

[Table 9] Healthy drink composition Citric acid 50 mg Vitamin B ₁ 5 mg Vitamin B ₂ 5 mg Vitamin B ₆ 5 mg Vitamin C 20 mg Caffeine 50 mg Glucose 10 g Fructose 3 g Sodium chloride 50 mg Potassium chloride 50 mg Alanine 100 mg Diglyceride 5 g Drink flavor Minor mineral water balance

[0039]

EFFECTS OF THE INVENTION By ingesting the health drink of the present invention, it is possible to promote utilization of fat accumulated in the body when energy is needed during sports and to positively supply necessary energy.

Claims (3)

[Claims] 1. A health drink containing diglyceride. 2. A health drink containing fats and oils in which diglycerides account for 50% by weight of all glycerides. 3. The content of diglyceride is 0.01% by weight.
It is above, The healthy drink of Claim 1 or 2.